US3008971A - Tetrahydropyranyl derivatives - Google Patents
Tetrahydropyranyl derivatives Download PDFInfo
- Publication number
- US3008971A US3008971A US70427A US7042760A US3008971A US 3008971 A US3008971 A US 3008971A US 70427 A US70427 A US 70427A US 7042760 A US7042760 A US 7042760A US 3008971 A US3008971 A US 3008971A
- Authority
- US
- United States
- Prior art keywords
- ethyl
- grams
- methyl
- propanediol
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 125000001412 tetrahydropyranyl group Chemical group 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 18
- -1 alkyl radical Chemical class 0.000 description 11
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 229940035437 1,3-propanediol Drugs 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000012280 lithium aluminium hydride Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000908 ammonium hydroxide Substances 0.000 description 3
- AOGYCOYQMAVAFD-UHFFFAOYSA-M carbonochloridate Chemical compound [O-]C(Cl)=O AOGYCOYQMAVAFD-UHFFFAOYSA-M 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000538 analytical sample Substances 0.000 description 2
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- VFTQJKSRDCKVQA-UHFFFAOYSA-N oxan-3-ylmethanol Chemical compound OCC1CCCOC1 VFTQJKSRDCKVQA-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003254 radicals Chemical group 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- CMAZEAMPHICYRN-UHFFFAOYSA-N (3-ethyloxan-3-yl)methanol Chemical compound CCC1(CO)CCCOC1 CMAZEAMPHICYRN-UHFFFAOYSA-N 0.000 description 1
- BKOOMYPCSUNDGP-UHFFFAOYSA-N 2-methylbut-2-ene Chemical compound CC=C(C)C BKOOMYPCSUNDGP-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical compound CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- VNUIKDVHZMWBTI-UHFFFAOYSA-N chloro carbamate Chemical compound NC(=O)OCl VNUIKDVHZMWBTI-UHFFFAOYSA-N 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
Definitions
- the present invention relates to novel tetrahydropyranyl derivatives and to a method of their preparation.
- novel tetrahydropyranyl derivatives of the present invention have the following formula:
- R stands for hydrogen or a lower alkyl radical having from 1 to 4 carbon atoms
- R stands for hydrogen or methyl
- R is a lower alkyl radical having from 1 to 4 carbon atoms.
- the products of the present invention may be prepared by reacting a S-hydroxymethyltetrahydropyran of the formula with phosgene to form the corresponding chlorocarbonate and treating said chlorocarbonate with either anhydrous ammonia or ammonium hydroxide.
- the S-hydroxymethyltetrahydropyran is obtained by reducing a diethyl R (carbethoxyethyDmalonate, for example, diethyl ethyl(carbethoxyethyhmalonate with lithium aluminum hydride and dehydrating the 2-R -2('y-hydroxypropyl)-1,3-propanediol, for example, 2-ethyl-2-('y-hydroxypropyl)-1,3- propanediol with potassium acid sulphate to give the desired starting 3-R -3hydroxymethyltetrahydropyran, for example, 3ethyl-3hydroxymethyltetrahydropyran.
- diethyl R carbbethoxyethyDmalonate
- diethyl ethyl(carbethoxyethyhmalonate with lithium aluminum hydride dehydrating the 2-R -2('y-hydroxypropyl)-1,3-propanediol, for example, 2-ethyl
- the starting 2,2-R,R 5-R -5hydroxymethyltetrahydropyran for example, 2,2- dimethyl-Sethyl-5hydroxymethyltetrahydropyran is obtained by reducing a diethyl R (3,3-R,R 2- propen ylmalonate, for example, diethyl ethyl(3,3-dimethyl-2-propenyl)- malonate with lithium aluminum hydride and cyclizing the 2-R -2(3,3-R,R -2-propenyl)-1,3- propanediol, for example, 2-ethyl-2(3,3-dimethyl-2-propen yl)-1,3-prop-anediol in the presence of a mineral acid to form the desired starting 2,2-R,R -5-R 5hydroxymethyltetrahydropyran, for example, 2,Z-dirnethyl-5ethyl-Shydroxymethyl
- PROPANEDIOL A solution of 175.4 grams of diethyl ethyl(carbethoxyethyl)ma1onate in 650 ml. anhydrous ethyl ether was added during 3.5 hours to 51.8 grams of lithium aluminum hydride in 1200 mls. of ethyl ether maintained at 1015 C. The mixture was allowed to stand overnight at room temperature and the complexes were decomposed. Carbon dioxide was passed into the mixture and the solids were collected. The solids were repeatedly washed with ethyl acetate. The combined organic extracts were evaporated to afiord 79 grams (80.5%) of crude 2-ethyl-2- ('y-hydroxypropyl) -1,3-propanediol.
- R is a radical selected from the group consisting of hydrogen and a lower alkyl radical having from 1 to 4 carbon atoms
- R is a radical selected from the group consisting of hydrogen and methyl
- R is a lower alkyl radical of from 1 to 4 carbon atoms.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
United States Patent The present invention relates to novel tetrahydropyranyl derivatives and to a method of their preparation.
The novel tetrahydropyranyl derivatives of the present invention have the following formula:
R. 011,0 0 ONE;
Wherein R stands for hydrogen or a lower alkyl radical having from 1 to 4 carbon atoms, R stands for hydrogen or methyl, and R is a lower alkyl radical having from 1 to 4 carbon atoms.
The products of the present invention may be prepared by reacting a S-hydroxymethyltetrahydropyran of the formula with phosgene to form the corresponding chlorocarbonate and treating said chlorocarbonate with either anhydrous ammonia or ammonium hydroxide.
When it is desired to prepare a compound wherein R and R both stand for hydrogen, the S-hydroxymethyltetrahydropyran is obtained by reducing a diethyl R (carbethoxyethyDmalonate, for example, diethyl ethyl(carbethoxyethyhmalonate with lithium aluminum hydride and dehydrating the 2-R -2('y-hydroxypropyl)-1,3-propanediol, for example, 2-ethyl-2-('y-hydroxypropyl)-1,3- propanediol with potassium acid sulphate to give the desired starting 3-R -3hydroxymethyltetrahydropyran, for example, 3ethyl-3hydroxymethyltetrahydropyran.
On the other hand, when the R stands for methyl and R stands for a lower alkyl radical, the starting 2,2-R,R 5-R -5hydroxymethyltetrahydropyran, for example, 2,2- dimethyl-Sethyl-5hydroxymethyltetrahydropyran is obtained by reducing a diethyl R (3,3-R,R 2- propen ylmalonate, for example, diethyl ethyl(3,3-dimethyl-2-propenyl)- malonate with lithium aluminum hydride and cyclizing the 2-R -2(3,3-R,R -2-propenyl)-1,3- propanediol, for example, 2-ethyl-2(3,3-dimethyl-2-propen yl)-1,3-prop-anediol in the presence of a mineral acid to form the desired starting 2,2-R,R -5-R 5hydroxymethyltetrahydropyran, for example, 2,Z-dirnethyl-5ethyl-Shydroxymethyltetrahydropyran. The products of the present invention have been found to possess sedative and muscle relaxing properties at a dose substantially lower than the lethal dose. Effective doses are listed in Table I.
It was further found that the 3-ethyltetrahydropyranyl- 3-methyl carbamate, when administered at a dose of 200 mg./kg., depressed and inactivated 100% of the animals. Accordingly, this compound was found to produce sedation at a dose which is approximately one third of the The following examples are given to illustrate the preparation of the products of the present invention and are not to be construed as limiting the invention.
EXAMPLE I.2,2-DIMETHYL-5ETHYL-5-HYDROXY- METHYLTETRAHYDROPYRAN (a) A solution of 84.4 grams of diethyl ethyl(3methyl- 2..-butenyl)-malonate in 280 ml. anhydrous ethyl ether was added dropwise during min. at 5 -10 C. to 18.7 grams of lithium aluminum hydride in 490 ml. anhydrous ethyl ether. The mixture was left at room temperature overnightv and the complex decomposed by the addition of methanol followed by water. The ethereal layer was separated. The solids were repeatedly extractedwith ethyl ether. The combined ethereal extracts were evaporated to give 49.4 grams of crude 2-ethyl-2(3-methyl-2- butenyl) -1,3 propanediol.
(b) The crude- 2-ethyl-2(3-methyl-2-butenyD-1,3-propanediol (15 grams) dissolved in 55 ml. tetrahydrofuran was refluxed three hours with 14.2 ml. 6 N hydrochloric acid. The tetrahydrofur an was removed by distillation. The residue was neutralized by the addition of dilute sodium hydroxide and then extracted with ethyl ether. The ethereal extract was washed with water and the solvent remained to give 15.4 grams 2,2-dimetlhyl-5-ethyl- 5hydroxymethyltetrahydropyran.
2,2-DIMETHYL-5ETHYLTETRAHYDROPYRANYL-5- METHYL CARBAMAIIE A solution of 14.4 grams of 2,2-dimethy'l-5-ethyl-5- hydrox-ymethyltetrahydropyran in 60 ml. tetrahydrofur-an was added dropwise accompanied by stirring during a period of 25 minutes to 12.4 grams of phosgene dissolved in 50 ml. of tetrahydnofuran with the temperature being maintained at 9 to 0 C. The mixture was stirred 15 minutes at this temperature and then a further 30 minutes at room temperature. The above chlorocarbonate solution was added during 55 minutes to 34.1 ml. of concentrated ammonium hydroxide maintained at 2 to 7 C. The mixture was stirred ten minutes at this temperature and then one hour at room temperature. The tetrahydrofuran and excess ammonia were distilled 0E. The remaining mixture was extracted with ethyl ether. The combined ethereal extracts were evaporated to yield 18.1 grams of crude product. This material was recrystallized from ethyl ether-petroleum ether to give 12.25 grams of 2,2-dim-ethyl-5ethyltetrahydropyranyl-S-methyl carbarnate. An analytical sample of this compound had a melting point of 73.5-74.5 C.
Analysis.Calculated for C H NO C: 61.36%, H: 9.81%, N: 6.51%. Found: C: 61.41%, H: 9.36%, N: 6.68%.
EXAMPLE II.2-ETHYL-2 ('y-HYDROXYPROPYL) -1,3-
PROPANEDIOL A solution of 175.4 grams of diethyl ethyl(carbethoxyethyl)ma1onate in 650 ml. anhydrous ethyl ether was added during 3.5 hours to 51.8 grams of lithium aluminum hydride in 1200 mls. of ethyl ether maintained at 1015 C. The mixture was allowed to stand overnight at room temperature and the complexes were decomposed. Carbon dioxide was passed into the mixture and the solids were collected. The solids were repeatedly washed with ethyl acetate. The combined organic extracts were evaporated to afiord 79 grams (80.5%) of crude 2-ethyl-2- ('y-hydroxypropyl) -1,3-propanediol.
3ETHYL 3HYDROXYMETHYLTETRAHYDROPYRAN A mixture of 11 grams of 2-ethyl-2('y-hydroxypropyD- 1,3-propanediol, 4 grams of potassium acid sulfate, and 0.2 gram of hydroquinone was distilled at 102-105 C./6 mm. to give 7.9 grams (80.8%) of 3-ethyl-3-hydroxymethyltetrahydropyran.
3-ETHYL'J3ETRAHYDROPYRANYIr3-METHYL CARBAMATE A solution of 37.22 grams of 3-ethyl-3-hydroxymethyltetrahydropynan in 150 m1. tetrahydrofuran was added during 45 minutes accompanied by stirring to 38.4 grams of phosgene' dissolved in 153 ml. tetrahydrofuran main tained at 0 to 5 C. The solution was stirred one hour at room temperature; The chlorocarbamate solution was added dropwise during 2.5 hours to 105 ml. of concen trated ammonium hydroxide and 12 grams of sodium bisulfi-te maintained at 5 to 8 C. Water was added and the tetrahydr'ofuran' was removed by distillation. The aqueous residue was extracted with ethyl ether and evaporation of the solvent gave 29.5 grams of 3-ethyltetrahydropyranyl-3-methyl carbamate. Recrystallization of this product from methanol aiforded an analytical sample having a melting point of 125.5 -1'26.5 C.
Analysis-Calculated for C H NO C: 57.74%; H: 9.16%; N: 7.48%. Found: C: 57.57%; H: 8.87%; I I: 7.71%.
4 We claim: 1. A compound of the formula:
R1 01120 OONH,
wherein R is a radical selected from the group consisting of hydrogen and a lower alkyl radical having from 1 to 4 carbon atoms, R is a radical selected from the group consisting of hydrogen and methyl, and R is a lower alkyl radical of from 1 to 4 carbon atoms.
2.- 3-ethyltetrahydropyranyl-3-methy1 carbamate.
3. 2,2-dimethyl-5-ethyltetrahydropyranyl-5-methyl carbamate.
No references cited.
Claims (1)
1. A COMPOUND OF THE FORMULA:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70427A US3008971A (en) | 1960-11-21 | 1960-11-21 | Tetrahydropyranyl derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70427A US3008971A (en) | 1960-11-21 | 1960-11-21 | Tetrahydropyranyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3008971A true US3008971A (en) | 1961-11-14 |
Family
ID=22095225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US70427A Expired - Lifetime US3008971A (en) | 1960-11-21 | 1960-11-21 | Tetrahydropyranyl derivatives |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3008971A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1284428B (en) * | 1963-09-20 | 1968-12-05 | Krewel Werke Gmbh | Process for the preparation of tetrahydrofuryl or tetrahydropyranyl carbamic acid esters |
| US3968236A (en) * | 1975-01-22 | 1976-07-06 | Merck & Co., Inc. | 2-Aminomethyl-5-hydroxy-4H-pyran-4-one and derivatives thereof |
| US4410744A (en) * | 1982-08-02 | 1983-10-18 | Thiokol Corporation | Making 1,2,4-butanetriol by hydroformylation of glycidol |
-
1960
- 1960-11-21 US US70427A patent/US3008971A/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| None * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1284428B (en) * | 1963-09-20 | 1968-12-05 | Krewel Werke Gmbh | Process for the preparation of tetrahydrofuryl or tetrahydropyranyl carbamic acid esters |
| US3968236A (en) * | 1975-01-22 | 1976-07-06 | Merck & Co., Inc. | 2-Aminomethyl-5-hydroxy-4H-pyran-4-one and derivatives thereof |
| US4410744A (en) * | 1982-08-02 | 1983-10-18 | Thiokol Corporation | Making 1,2,4-butanetriol by hydroformylation of glycidol |
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