US3069359A - Germicidal detergent composition - Google Patents
Germicidal detergent composition Download PDFInfo
- Publication number
- US3069359A US3069359A US723943A US72394358A US3069359A US 3069359 A US3069359 A US 3069359A US 723943 A US723943 A US 723943A US 72394358 A US72394358 A US 72394358A US 3069359 A US3069359 A US 3069359A
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- US
- United States
- Prior art keywords
- neomycin
- ethylene oxide
- moles
- water
- reaction product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000003599 detergent Substances 0.000 title claims description 25
- 230000002070 germicidal effect Effects 0.000 title claims description 12
- 239000000203 mixture Substances 0.000 title description 16
- 229930193140 Neomycin Natural products 0.000 claims description 17
- 229960004927 neomycin Drugs 0.000 claims description 17
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 11
- 239000007795 chemical reaction product Substances 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims description 3
- 239000012458 free base Substances 0.000 claims description 3
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 3
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- LIFHMKCDDVTICL-UHFFFAOYSA-N 6-(chloromethyl)phenanthridine Chemical compound C1=CC=C2C(CCl)=NC3=CC=CC=C3C2=C1 LIFHMKCDDVTICL-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 125000002877 alkyl aryl group Chemical group 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000004166 Lanolin Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000008149 soap solution Substances 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- GLDUZMNCEGHSBP-UHFFFAOYSA-N 2-(2-octylphenoxy)ethanol Chemical class CCCCCCCCC1=CC=CC=C1OCCO GLDUZMNCEGHSBP-UHFFFAOYSA-N 0.000 description 1
- IDOQDZANRZQBTP-UHFFFAOYSA-N 2-[2-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=CC=C1OCCO IDOQDZANRZQBTP-UHFFFAOYSA-N 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- QZXSMBBFBXPQHI-UHFFFAOYSA-N N-(dodecanoyl)ethanolamine Chemical compound CCCCCCCCCCCC(=O)NCCO QZXSMBBFBXPQHI-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 241000187438 Streptomyces fradiae Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 229920004929 Triton X-114 Polymers 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- PXWCUJRVSZCPHE-UHFFFAOYSA-N alpha-Butyl-omega-hydroxypoly(oxyethylene) poly(oxypropylene) Chemical compound CCCCOCCOCC(C)OCCCOC PXWCUJRVSZCPHE-UHFFFAOYSA-N 0.000 description 1
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 1
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- MKHVZQXYWACUQC-UHFFFAOYSA-N bis(2-hydroxyethyl)azanium;dodecyl sulfate Chemical compound OCCNCCO.CCCCCCCCCCCCOS(O)(=O)=O MKHVZQXYWACUQC-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940053050 neomycin sulfate Drugs 0.000 description 1
- -1 organic acid esters Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- GBEYVKHMIPVAHD-UHFFFAOYSA-M potassium;hexadecyl sulfate Chemical compound [K+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GBEYVKHMIPVAHD-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- HFQQZARZPUDIFP-UHFFFAOYSA-M sodium;2-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O HFQQZARZPUDIFP-UHFFFAOYSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T24/00—Buckles, buttons, clasps, etc.
- Y10T24/14—Bale and package ties, hose clamps
- Y10T24/1498—Plastic band
Definitions
- This invention relates to a germicidal detergent composition containing neomycin.
- Neomycin is a well-known antibiotic produced by propagation of microorganisms of the species Streptomyces fradiae as described in United States patent to Waksman No. 2,799,620. Attempts have been made to take advantage of the bacteriostatic properties of neornycin for topical application by incorporating the neomycin, usually as the sulfate, in various aqueous preparations such as soaps and the like. However, this proposal has met with difficulty because neomycin has a known stability range of from about pH 2 to about pH 9 and ordinary soap solutions have a hydrogen ion concentration well above pH 9. Consequently, the antibacterial properties of neomycin are destroyed in such solutions.
- the present invention is predicated upon the discovery that if a small amount of a nonionic surface active agent is incorporated into the anionic detergent along with the neomycin, the neomycin is rendered stable and does not precipitate out on standing,
- the present invention preferably embodies a germicidal detergent composition comprising from about to about of a water-soluble organic anionic detergent, a small but effective amount of neomycin usually from about 0.1 to about 3% (as the base), and from about 0.1 to about 2.0% of a nonionic surface active agent, the resulting composition having a pH of from about 5-7 so that the composition is virtually free of irritating effects on the skin.
- the suitable anionic detergents are the watersoluble higher fatty acid soaps (cg. sodium lauryl sulfate, sodium salts of higher fatty acids derived from coconut oil, palm oil and tallow), and the sulfated and sulfonated organic detergents.
- water soluble salts of higher alkyl aryl sulfonate eg. sodium dodecyibenzenesulfonate, sodium laurylbenzenesulfonate
- higher alkyl sulfate detergent e.g.
- higher fatty acids eg. sodium coconut monogylceride monosulfate
- sulfated hi her fatty acid amides e.g. sodium lauric monoethanolamide sulfate
- nonionic detergents are the polyalkylene oxide condensates with hydrophobic organic compounds, usually of an aliphatic or an aromatic structure.
- suitable examples thereof are the higher alkyl aryl polyglycol ethers (cg. octylphenol or nonylphenol condensed with 6 to 30 moles ethylene oxide), organic acid esters with ethylene oxide (eg. tall oil esters with 6 to 30 moles of ethylene oxide), and alkyl aryl polyethylene glycol ethers of polypropylene glycol having a molecular weight of about 2,000 to 10,000, etc.
- Particularly preferred surface active agents for use in the present invention are the nonionic octylphenoxyethanol series of com pounds sold under the trademark Triton, such as Triton X-100, Triton X-114 etc. and corresponding to the formula:
- n is from 6-30.
- Example 1 A germicidal detergent composition is prepared by dissolving 1.5 parts of neomycin sulfate in 40 parts by volume of water. 10 parts by volume of Triton X-l00 (reaction product of 9-10 moles of ethylene oxide with octylphenol) are added and the mixture stirred until clear. 10 parts by volume of Triton X-l l4 (reaction product of 7-8 moles of ethylene oxide with octylphenol), 20 parts by volume of triethanolamine lauryl sulfate and 2 parts of Lanogel 41 (a water-soluble derivative of lanolin) are added with stirring until the solution is clear. Sufficient water is added to make up parts by volume. A clear, sparkling yellow solution is obtained. The pH is adjusted to pH 6.0 with citric acid. The neomycin is compatible in this anionic detergent and nonionic detergent solutions and remains stable for severeal months at room temperature, and for two months at 42 C. or for one Week at 56 C.
- Triton X-l00
- Example 2 A germicidal detergent composition is prepared following the procedure of Example 1 except that 8 parts of lngepal 00-710 (nonylphenoxypolyoxyethylene) is "seal in place or" the Triton X-l00 used in Example 1.
- the resulting germicidal detergent composition has substantially the same properties as the composition of Example 1 and is stable for relatively the same period.
- Example 3 A germicidal detergent composition is prepared following [the procedure of Example 1 except that 10 parts of Tergitol-Nonionic XD (alkyl aryl polyethylene glycol ether) is used in place of the Triton X-100 used in Example l.
- the resulting germicidal detergent composition has substantially the same properties as the composition of Example 1 and is stable for relatively the same period.
- a clear sparkling germicidal detergent solution comprising from about 5 to about 40% of a water-soluble organic anionic detergent, a small but effective amount of a therapeutically effective form of neomycin equivalent to from about 0.1 to 3% neomycin calculated as the free base, and from about 0.1 to about 20% of a nonionic surface active agent selected from the group consisting of the reaction product of octylphenol with from 6 to 30 moles of ethylene oxide and the reaction product of nonylphenoi with from about 6 to 30 moles of ethylene oxide, the resulting clear sparkling solution having added sufficient non-toxic organic acid and water to have a pH of between about 5 and about 7 and total 100%.
- composition of claim 1 in which the anionic detergent is triethanolamine lauryl sulfate.
- a clear sparkling germicidal detergent solution consisting essentially of from about 5 to about 40% of triethanolamine lauryl sulfate, a small but effective amount of a therapeutically effective form of neomycin equivalent to from about 0.1 to 3% neomycin calculated as the free base, from about 0.1 to about 20% of a nonionic surface active agent selected from the group consisting of the reaction product of octylphenol With from 6 to 30 moles of ethylene oxide and the reaction product of nonylphenol with from about 6 to 30 moles of ethylene oxide, about 2% of a water-soluble derivative of lanolin, sufiicient citric acid to adjust the pH to between about 5 and about 7, and Water to a total of 100%, said solution being stable for at least two months at 42 C.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
3,009,359 Patented Dec. 18, 1962 3,069,359 GERl /HCHDAL DETERGENT IUWQSHEQN Jack Biodinger, Monsey, N.Y., assiguor to American (Zyanainid Company, New York, N311, a corporation of Maine No Drawing. Filed Mar. 26, 1953, Ser. No. 723,943 3 Claims. (61. 252-107) This invention relates to a germicidal detergent composition containing neomycin.
Neomycin is a well-known antibiotic produced by propagation of microorganisms of the species Streptomyces fradiae as described in United States patent to Waksman No. 2,799,620. Attempts have been made to take advantage of the bacteriostatic properties of neornycin for topical application by incorporating the neomycin, usually as the sulfate, in various aqueous preparations such as soaps and the like. However, this proposal has met with difficulty because neomycin has a known stability range of from about pH 2 to about pH 9 and ordinary soap solutions have a hydrogen ion concentration well above pH 9. Consequently, the antibacterial properties of neomycin are destroyed in such solutions. If the pH of the soap solution is lowered to any extent or if the neomycin is incorporated in conventional anionic detergents, it is founc. that the neomycin is incompatible with such detergents and a heavy precipitate occurs rendering the resultant composition useless as a germicidal cleaning composition.
The present invention is predicated upon the discovery that if a small amount of a nonionic surface active agent is incorporated into the anionic detergent along with the neomycin, the neomycin is rendered stable and does not precipitate out on standing, The present invention preferably embodies a germicidal detergent composition comprising from about to about of a water-soluble organic anionic detergent, a small but effective amount of neomycin usually from about 0.1 to about 3% (as the base), and from about 0.1 to about 2.0% of a nonionic surface active agent, the resulting composition having a pH of from about 5-7 so that the composition is virtually free of irritating effects on the skin.
Among the suitable anionic detergents are the watersoluble higher fatty acid soaps (cg. sodium lauryl sulfate, sodium salts of higher fatty acids derived from coconut oil, palm oil and tallow), and the sulfated and sulfonated organic detergents. Examples of the latter are water soluble salts of higher alkyl aryl sulfonate (eg. sodium dodecyibenzenesulfonate, sodium laurylbenzenesulfonate), higher alkyl sulfate detergent (e.g. sodium lauryl sulfate, potassium cetyl sulfate, triethanolamine lauryl sulfate, diethanolamine lauryl sulfate and ammonium lauryl sulfate), sulfuric acid esters of polyhydric alcohols incompletely esterified with higher fatty acids (eg. sodium coconut monogylceride monosulfate), sulfated hi her fatty acid amides (e.g. sodium lauric monoethanolamide sulfate), etc.
Among the suitable nonionic detergents are the polyalkylene oxide condensates with hydrophobic organic compounds, usually of an aliphatic or an aromatic structure. Suitable examples thereof are the higher alkyl aryl polyglycol ethers (cg. octylphenol or nonylphenol condensed with 6 to 30 moles ethylene oxide), organic acid esters with ethylene oxide (eg. tall oil esters with 6 to 30 moles of ethylene oxide), and alkyl aryl polyethylene glycol ethers of polypropylene glycol having a molecular weight of about 2,000 to 10,000, etc. Particularly preferred surface active agents for use in the present invention are the nonionic octylphenoxyethanol series of com pounds sold under the trademark Triton, such as Triton X-100, Triton X-114 etc. and corresponding to the formula:
osuh-Q o crnonnnon and wherein n is from 6-30, and the nonylphenoxypolyoxyethylene compounds sold under the trademark Igepal corresponding to the formula:
OQHH-Q- O cutout) non wherein n is from 6-30.
The invention will be described in greater detail in conjunction with the following specific examples in which the parts are by weight unless otherwise specified.
Example 1 A germicidal detergent composition is prepared by dissolving 1.5 parts of neomycin sulfate in 40 parts by volume of water. 10 parts by volume of Triton X-l00 (reaction product of 9-10 moles of ethylene oxide with octylphenol) are added and the mixture stirred until clear. 10 parts by volume of Triton X-l l4 (reaction product of 7-8 moles of ethylene oxide with octylphenol), 20 parts by volume of triethanolamine lauryl sulfate and 2 parts of Lanogel 41 (a water-soluble derivative of lanolin) are added with stirring until the solution is clear. Sufficient water is added to make up parts by volume. A clear, sparkling yellow solution is obtained. The pH is adjusted to pH 6.0 with citric acid. The neomycin is compatible in this anionic detergent and nonionic detergent solutions and remains stable for severeal months at room temperature, and for two months at 42 C. or for one Week at 56 C.
Example 2 A germicidal detergent composition is prepared following the procedure of Example 1 except that 8 parts of lngepal 00-710 (nonylphenoxypolyoxyethylene) is "seal in place or" the Triton X-l00 used in Example 1. The resulting germicidal detergent composition has substantially the same properties as the composition of Example 1 and is stable for relatively the same period.
Example 3 A germicidal detergent composition is prepared following [the procedure of Example 1 except that 10 parts of Tergitol-Nonionic XD (alkyl aryl polyethylene glycol ether) is used in place of the Triton X-100 used in Example l. The resulting germicidal detergent composition has substantially the same properties as the composition of Example 1 and is stable for relatively the same period.
1 claim:
1. A clear sparkling germicidal detergent solution comprising from about 5 to about 40% of a water-soluble organic anionic detergent, a small but effective amount of a therapeutically effective form of neomycin equivalent to from about 0.1 to 3% neomycin calculated as the free base, and from about 0.1 to about 20% of a nonionic surface active agent selected from the group consisting of the reaction product of octylphenol with from 6 to 30 moles of ethylene oxide and the reaction product of nonylphenoi with from about 6 to 30 moles of ethylene oxide, the resulting clear sparkling solution having added sufficient non-toxic organic acid and water to have a pH of between about 5 and about 7 and total 100%.
2. The composition of claim 1 in which the anionic detergent is triethanolamine lauryl sulfate.
3. A clear sparkling germicidal detergent solution consisting essentially of from about 5 to about 40% of triethanolamine lauryl sulfate, a small but effective amount of a therapeutically effective form of neomycin equivalent to from about 0.1 to 3% neomycin calculated as the free base, from about 0.1 to about 20% of a nonionic surface active agent selected from the group consisting of the reaction product of octylphenol With from 6 to 30 moles of ethylene oxide and the reaction product of nonylphenol with from about 6 to 30 moles of ethylene oxide, about 2% of a water-soluble derivative of lanolin, sufiicient citric acid to adjust the pH to between about 5 and about 7, and Water to a total of 100%, said solution being stable for at least two months at 42 C.
References Cited in the file of this patent UNlTED STAT ES PATENTS 2,865,859 Lubowe Dec. 23, 1958 2,880,130 Johnson Mar. 31, 1959 2,880,138 Johnson Mar. 31, 1959 2,942,008 Lubowe June 21, 1960 4 Reed Jan, 17, 1961 Goyan et al. Mar. 14, 1961 Parlour Apr. 11, 1961 Cyr et a1 Apr. 10, 1962 FOREIGN PATENTS Great Britain Nov. 14, 1956 France Feb. 18, 1948 OTHER REFERENCES Heatley et al.: J. Gen. Microbiology, vol. 6, 1952, p.
J. Pharmacy, July 1952, p. 6243. Dale: J.A.P.A., Prac. Pharrn. Ed, July 1957, pp. 421- Livingood et al.:
Claims (1)
1. A CLEAR SPARKLING GERMICIDAL DETERGENT SOLUTION COMPRISING FROM ABOUT 5 TO ABOUT 40% OF A WATER-SOLUBLE ORGANIC ANIONIC DETERGENT, A SMALL BUT EFFECTIVE AMOUNT OF A THERAPEUTICALLY EFFECTIVE FROM OF NEOMYCIN EQUIVALENT TO FORM ABOUT 0.1 TO 3% NEOMYCIN CALCULATED AS THE FREE BASE, AND FROM ABOUT 0.1 TO ABOUT 20% OF A NONIONIC SURFACE ACTIVE AGENT SELECTED FROM THE GROUP CONSISTING OF THE REACTION PRODUCT OF OCTYLPHENOL WITH FROM 6 TO 30 MOLES OF ETHYLENE OXIDE AND THE REACTION PRODUCT OF NONYLPHENOL WITH FROM ABOUT 6 TO 30 MOLES OF ETHYLENE OXIDE, THE RESULTING CLEAR SPARKLING SOLUTION HAVING ADDED SUFFICIENT NON-TOXIC ORGANIC ACID AND WATER TO HAVE A PH OF BETWEEN ABOUT 5 TO ABOUT 7 AND TOTAL 100%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US723943A US3069359A (en) | 1958-03-26 | 1958-03-26 | Germicidal detergent composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US723943A US3069359A (en) | 1958-03-26 | 1958-03-26 | Germicidal detergent composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3069359A true US3069359A (en) | 1962-12-18 |
Family
ID=24908337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US723943A Expired - Lifetime US3069359A (en) | 1958-03-26 | 1958-03-26 | Germicidal detergent composition |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3069359A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3174905A (en) * | 1962-03-12 | 1965-03-23 | American Cyanamid Co | Methods and compositions for rendering textile materials soft, germ resistant and antistatic |
| US3951841A (en) * | 1972-06-08 | 1976-04-20 | Discwasher Inc. | Phonograph record cleaning composition |
| WO2005044965A1 (en) * | 2003-11-10 | 2005-05-19 | Schwarzwälder Marketing Gmbh & Co. | Use of a solution comprising at least one nonionic surfactant |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR931270A (en) * | 1945-02-10 | 1948-02-18 | Sharp & Dohme | Process for preparing bacteriostatic compositions |
| GB761269A (en) * | 1953-04-24 | 1956-11-14 | American Cyanamid Co | Improvements in or relating to antiseptic detergent compositions and process of making the same |
| US2865859A (en) * | 1956-11-09 | 1958-12-23 | Irwin I Lubowe | Solubilizing of mineral, vegetable, animal oils for cosmetic, pharmaceutical and industrial purposes |
| US2880138A (en) * | 1956-12-24 | 1959-03-31 | Upjohn Co | Anti-inflammatory steroid solutions |
| US2880130A (en) * | 1956-12-24 | 1959-03-31 | Upjohn Co | Anti-inflammatory steroid solutions |
| US2942008A (en) * | 1956-12-10 | 1960-06-21 | Irwin I Lubowe | Solubilizing of mineral, vegetable, and animal oils for cosmetic, pharmaceutical, and industrial purposes |
| US2968628A (en) * | 1958-10-17 | 1961-01-17 | Shulton Inc | Propellant composition |
| US2975099A (en) * | 1958-06-25 | 1961-03-14 | Upjohn Co | Polyethylene glycol suppository bases |
| US2979410A (en) * | 1957-05-13 | 1961-04-11 | Tee Pak Inc | Food package and packaging film therefor |
| US3029188A (en) * | 1958-02-20 | 1962-04-10 | Olin Mathieson | Gelatin adhesive pharmaceutical preparations |
-
1958
- 1958-03-26 US US723943A patent/US3069359A/en not_active Expired - Lifetime
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR931270A (en) * | 1945-02-10 | 1948-02-18 | Sharp & Dohme | Process for preparing bacteriostatic compositions |
| GB761269A (en) * | 1953-04-24 | 1956-11-14 | American Cyanamid Co | Improvements in or relating to antiseptic detergent compositions and process of making the same |
| US2865859A (en) * | 1956-11-09 | 1958-12-23 | Irwin I Lubowe | Solubilizing of mineral, vegetable, animal oils for cosmetic, pharmaceutical and industrial purposes |
| US2942008A (en) * | 1956-12-10 | 1960-06-21 | Irwin I Lubowe | Solubilizing of mineral, vegetable, and animal oils for cosmetic, pharmaceutical, and industrial purposes |
| US2880138A (en) * | 1956-12-24 | 1959-03-31 | Upjohn Co | Anti-inflammatory steroid solutions |
| US2880130A (en) * | 1956-12-24 | 1959-03-31 | Upjohn Co | Anti-inflammatory steroid solutions |
| US2979410A (en) * | 1957-05-13 | 1961-04-11 | Tee Pak Inc | Food package and packaging film therefor |
| US3029188A (en) * | 1958-02-20 | 1962-04-10 | Olin Mathieson | Gelatin adhesive pharmaceutical preparations |
| US2975099A (en) * | 1958-06-25 | 1961-03-14 | Upjohn Co | Polyethylene glycol suppository bases |
| US2968628A (en) * | 1958-10-17 | 1961-01-17 | Shulton Inc | Propellant composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3174905A (en) * | 1962-03-12 | 1965-03-23 | American Cyanamid Co | Methods and compositions for rendering textile materials soft, germ resistant and antistatic |
| US3951841A (en) * | 1972-06-08 | 1976-04-20 | Discwasher Inc. | Phonograph record cleaning composition |
| WO2005044965A1 (en) * | 2003-11-10 | 2005-05-19 | Schwarzwälder Marketing Gmbh & Co. | Use of a solution comprising at least one nonionic surfactant |
| US20070093405A1 (en) * | 2003-11-10 | 2007-04-26 | Ursula Maier | Use of a solution comprising at least one nonionic surfactant |
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