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US20240277954A1 - Device for nasal delivery of a fluid product - Google Patents

Device for nasal delivery of a fluid product Download PDF

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Publication number
US20240277954A1
US20240277954A1 US18/572,363 US202218572363A US2024277954A1 US 20240277954 A1 US20240277954 A1 US 20240277954A1 US 202218572363 A US202218572363 A US 202218572363A US 2024277954 A1 US2024277954 A1 US 2024277954A1
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Prior art keywords
vessel
compressed gas
actuating
fluid product
support member
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Pending
Application number
US18/572,363
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English (en)
Inventor
Matthieu Baillet
Guilaume DU BOISBAUDRY
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Aptar France SAS
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Aptar France SAS
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Publication date
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Publication of US20240277954A1 publication Critical patent/US20240277954A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0027—Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means
    • B05B11/0032—Manually actuated means located downstream the discharge nozzle for closing or covering it, e.g. shutters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0054—Cartridges, i.e. containers specially designed for easy attachment to or easy removal from the rest of the sprayer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/061—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump characterised by the means producing the gas or vapour pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/16—Actuating means
    • B65D83/164—Actuators comprising a manually operated valve and being attachable to the aerosol container, e.g. downstream a valve fitted to the container; Actuators associated to container valves with valve seats located outside the aerosol container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/38—Details of the container body
    • B65D83/384—Details of the container body the container body being an aerosol container located in an outer shell or in an external container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
    • B65D83/52—Metering valves; Metering devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/60—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant with contents and propellant separated

Definitions

  • the present invention relates to a device for nasal delivery of fluid product, and more specifically, a device for dispensing into a nostril, a dose of pharmaceutical fluid product, in particular liquid or powder, contained in a vessel, using a pressurised gas flow.
  • Documents WO9946055 and WO0245866 disclose nasal delivery devices, wherein a spherical closing element, which blocks the outlet of the vessel, is expelled by the airflow created by an air purge actuated manually by the user.
  • a disadvantage of this type of device is the manual air expeller, which can in the example of document WO9946055 deliver a variable air flow depending on the way in which the device is actuated.
  • a disadvantage of this type of device is the manual air purge, which can, in the example of document WO9946055, deliver a variable airflow according to the way in which the device is actuated.
  • Document WO0245866 resolves this problem by proposing an actuating end position mechanical opening, but to guarantee a sufficient airflow, the actuation of the air purge can prove to be difficult for vulnerable people.
  • Document WO2020154182 proposes to replace the manual air purge by a compressed gas vessel which is opened during actuation to dispense the dose of fluid product.
  • the device comprises a double-pointed needle, and when the user presses on the bottom of the vessel, the needle will pierce both the fluid product vessel and the compressed gas vessel, thus enabling the compressed gas to dispense the dose of fluid product.
  • This implementation has the disadvantage of having to exert an axial force, while the device is in the nostril of the user, with risks of discomfort or injury during the triggering of the compressed gas flow.
  • An object of the present invention is to provide a device for nasal delivery of fluid product that does not have the above-mentioned drawbacks.
  • the present invention aims to provide such a device which guarantees the expulsion of the dose of fluid product, independently from the speed or from the actuating force.
  • the present invention also aims to provide such a device which prevents any risk of injury in the nostril during actuation.
  • the present invention also aims to provide such a device which is simple and inexpensive to manufacture, to assemble, to fill and to use.
  • the present invention therefore aims for a fluid product dispensing device, comprising a vessel containing a dose of fluid product to be dispensed, a compressed gas vessel suitable for dispensing a dose of compressed gas to expel the dose of fluid product during actuation, and an intermediate portion comprising a body and connection means for connecting said fluid product vessel to said compressed gas vessel, and actuating means for actuating said device, said connection means comprising a first support member and a second support member movable axially with respect to said body, and a flexible and deformable tube attached both to said first support member and to said second support member, said first support member comprising first opening means for, in the actuating position, opening said fluid product vessel, and said second support member comprising second opening means for, in the actuating position, opening said compressed gas vessel, a loaded spring being disposed between said first and second support members, for elastically urging them to their respective actuating position, said actuating means comprising an actuating button which can move radially between a rest position and
  • said fluid product vessel contains a single dose of fluid product.
  • said first opening means comprise a first needle, connected to said flexible tube, and which, in the actuating position, pierces a membrane of said fluid product vessel.
  • said compressed gas vessel contains a single dose of compressed gas.
  • said second opening means comprise a second needle, connected to said flexible tube, and which, in the actuating position, pierces a membrane of said compressed gas vessel.
  • said compressed gas vessel contains several doses of compressed gas.
  • said second opening means comprise a valve well, connected to said flexible tube, and which engages with a valve of a dosing valve mounted on said compressed gas vessel.
  • said hollow cage comprises an upper axial wall and a lower axial wall, each axial wall comprising wall parts and axial openings.
  • an upper axial edge of said first support member is locked axially by a wall portion of said upper axial wall
  • a lower axial edge of said second support member is locked axially by a wall portion of said lower axial wall.
  • an axial opening of said upper axial wall is positioned facing said upper axial edge of said first support member, and an axial opening of said lower axial wall is positioned facing said lower axial edge of said second support member.
  • said flexible tube in the rest position, is deformed and/or twisted, and when said two support members move axially relative to one another to their respective actuating positions, said flexible tube straightens, to compensate for the axial gap generated between the two support members during actuation.
  • said fluid product vessel and said compressed gas vessel are opened simultaneously.
  • said fluid product vessel is opened just before said compressed gas vessel.
  • said vessel is of the BFS (Blow-Fill-Seal) or FFS (Form-Fill-Seal) type, i.e. produced by blowing or forming, filling and sealing continuously.
  • BFS Bit-Fill-Seal
  • FFS Form-Fill-Seal
  • said vessel comprises attachment means for attaching said vessel to said intermediate portion, in particular, removably.
  • FIG. 1 is a schematic, vertical cross-sectional view of a device for dispensing fluid product according to a first advantageous embodiment, before actuation,
  • FIG. 2 is a view similar to that of FIG. 1 , shown after actuation,
  • FIGS. 3 and 4 are views similar to those of FIGS. 1 and 2 , seen according to a different angle,
  • FIG. 5 is a detailed schematic, vertical cross-sectional view of the device of FIG. 3 .
  • FIG. 6 is a detailed schematic, vertical cross-sectional view of the device of FIG. 4 .
  • FIG. 7 is a schematic, top, horizontal cross-sectional view of the intermediate portion, before actuation
  • FIG. 8 is a view similar to that of FIG. 7 , shown after actuation,
  • FIG. 9 is a schematic, perspective view of a device for dispensing fluid product according to a second advantageous embodiment, before actuation, and
  • FIG. 10 is a schematic, perspective, cutout view of the device of FIG. 9 , after actuation.
  • the terms “upper”, “lower”, “top”, “bottom”, “vertical” and “horizontal” refer to the upright position of the device represented in FIGS. 1 to 4 , 9 and 10 .
  • the terms “axial” and “radial” refer to the longitudinal central axis A of the device, represented in FIG. 1 .
  • the device comprises three main portions, namely a vessel 10 containing a dose of fluid product to be dispensed, in particular a medication in powder- or liquid-form, a compressed gas vessel 20 suitable for dispensing a dose of compressed gas during actuation to expel the dose of fluid product during actuation, and an intermediate 30 portion 30 connecting the vessel 10 to the compressed gas vessel 20 and enabling the actuation of the device.
  • a vessel 10 containing a dose of fluid product to be dispensed in particular a medication in powder- or liquid-form
  • a compressed gas vessel 20 suitable for dispensing a dose of compressed gas during actuation to expel the dose of fluid product during actuation
  • an intermediate 30 portion 30 connecting the vessel 10 to the compressed gas vessel 20 and enabling the actuation of the device.
  • the vessel 10 can be formed directly in an axially elongated dispensing head 11 , the axial end of which comprises a dispensing orifice 12 , and which is intended to be inserted into the nostril of a user, as represented in the examples of the figures.
  • the vessel could be separated from the dispensing head.
  • the vessel 10 is of the BfS (Blow-Fill-Seal) or FFS (Form-Fill-Seal) type, i.e. that the vessel 10 is produced by blowing or forming, filling and sealing continuously, preferably in a sterile enclosure.
  • BfS Blow-Fill-Seal
  • FFS Form-Fill-Seal
  • the dispensing orifice 12 is closed by a removable stopper 15 which is removed just before the use of the device. After removal of the stopper 15 , the dispensing orifice 12 is open.
  • the vessel 10 On the side axially opposite the dispensing orifice 12 , the vessel 10 is closed by a membrane 17 suitable for being opened, in particular pierced, during actuation, as will be described below.
  • the reservoir 10 comprises fastening means 16 for fastening the reservoir 10 to the intermediate portion 30 .
  • This attachment can be non-detachable, when the device is single-use and disposable after actuation.
  • the attachment can be dismountable, to replace an empty vessel with a full vessel, when the device is reusable.
  • An example of a dismountable attachment would be a rotary attachment of the Luer type, well-known in the field of syringes.
  • the compressed gas vessel 20 contains one single dose of compressed gas.
  • the compressed gas vessel 20 can be non-detachable from the intermediate portion 30 if the device is single-use and disposable after use.
  • the compressed gas vessel 20 could be dismountable to replace an empty gas vessel 20 with a full gas vessel 20 , when the device is reusable.
  • the compressed gas vessel 20 is closed by a membrane 21 suitable for being opened, in particular pierced, during actuation, as will be described below.
  • the compressed gas vessel 20 contains several doses of compressed gas.
  • the compressed gas vessel 20 preferably comprises a dosing valve 25 comprising a valve 26 which is movable axially in the valve during actuation for dispensing a dose of compressed gas.
  • the opening of the compressed gas vessel 20 thus occurs when the valve 26 is moved to its actuated position, by being pressed axially in the valve body, in a well-known manner.
  • the dosing valves operating with compressed gases are well-known, and the dosing valve 25 , which can be of any existing type, will not be described in more detail in this case.
  • the intermediate portion 30 comprises a body 31 provided with an upper body portion 32 and a lower body portion 33 .
  • the upper body portion 32 advantageously comprises complementary attachment means of the attachment means 16 of the vessel 10 , for example a standard attachment of the Luer type.
  • the lower body portion 33 receives the compressed gas vessel 20 .
  • An actuating button 35 is mounted radially sliding in the body 31 between a rest position and an actuating position, wherein the actuating button 35 is pressed radially to the inside of the body 31 .
  • the actuating button 35 is rigidly connected to a hollow cage 36 .
  • the hollow cage 36 comprises an upper axial wall 37 and a lower axial wall 38 , each axial wall 37 , 38 comprising wall portions 371 , 381 and axial openings 372 , 382 which can be seen in FIGS. 5 to 8 .
  • the body 31 of the intermediate portion 30 contains a first support member 40 and a second support member 50 disposed around one another by each being movable axially with respect to the body 31 .
  • the first support member 40 is movable axially upward between its rest position and its actuating position
  • the second support member 50 is movable axially downward between its rest position and its actuating position.
  • the first support member 40 comprises an upper axial edge 41 and the second support member 50 comprises a lower axial edge 51 .
  • a flexible and deformable tube 60 is attached both to the first support member 40 and to the second support member 50 .
  • this flexible tube In the rest position, this flexible tube is deformed and/or twisted, and when the two support members 40 , 50 move axially relative to one another to their respective actuating positions, the flexible tube 60 straightens, thus making it possible to compensate for the axial gap generated between the two support members 40 , 50 during actuation.
  • the first support member 40 comprises first opening means 45 of the fluid product vessel 10 .
  • these first opening means comprise a first needle 45 , connected to said flexible tube 60 , and which, in the actuating position, pierces the membrane 17 of the vessel 10 .
  • the second support member 50 comprises second opening means 55 of the compressed gas vessel 20 .
  • these second opening means comprise a second needle 55 , connected to said flexible tube 60 , and which, in the actuating position, pierces the membrane 21 of the compressed gas vessel 20 .
  • the content of the compressed gas vessel 20 is connected to the content of the fluid product vessel 10 via the two needles 55 , 45 and the flexible tube 60 , ensuring the dispensing of said fluid product through the dispensing orifice 12 .
  • a loaded spring 70 is disposed between said first and second support members 40 , 50 , for elastically urging them to their respective actuating position.
  • the hollow cage 36 in the rest position of the actuating button 35 , locks said support members 40 , 50 in their rest positions, and when the actuating button 35 is radially moved to its actuating position, the support members 40 , 50 are unlocked and the spring 70 moves the two support members 40 , 50 to their respective actuating positions.
  • the actuation of the side actuating button 35 simultaneously generates the opening of the fluid product vessel and the opening of the compressed gas vessel 20 .
  • the properties of the spring 70 make it possible to predetermine the performances of the spray generated at the outlet of the dispensing orifice 12 .
  • the upper axial edge 41 of the first support member 40 abuts against a wall portion 371 of the upper axial wall 37 of the cage 36 and the lower axial edge 51 of the second support member 50 abuts against a wall portion 381 of the lower axial wall 38 of the cage 36 .
  • the user When the user wishes to use the device, they first remove the stopper 15 from the dispensing orifice 12 of the vessel 10 , and places the dispensing head in a nostril. They thus press the actuating button 35 , this actuating movement being lateral and non-axial, to move the cage 36 radially in the body 31 and release axially the two support members 40 , 50 .
  • the spring 70 thus automatically actuates and dispenses the dose of fluid product contained in the vessel 10 by means of the compressed gas contained in the compressed gas vessel 20 .
  • the device After use, the device is disposed of, if it is single-use.
  • the actuating button 35 advantageously comprises re-arm means to return it into the rest position after each actuation.
  • these re-arm means comprise an elastic element, such as a second spring.
  • the force exerted by this second spring is greater than the force exerted by the spring 70 , such that re-arming is done automatically, first by returning the actuating button 35 to its rest position, and also by returning the two support members 40 , 50 to their respective rest positions, by refilling the spring 70 .
  • a compressed gas vessel 20 is used, containing several doses of compressed gas, the device thus being reusable, with change of the vessel 10 after each actuation.
  • the second support member 50 does not comprise a needle for piercing a membrane, but engages with the valve 26 of the dosing valve 25 mounted on the compressed gas vessel 20 .
  • a dose of compressed gas is delivered to dispense the fluid product contained in the vessel 10 .
  • the actuating button 35 comprises re-arm means to return it into the rest position after each actuation.
  • these re-arm means comprise an elastic element, such as a second spring.
  • the force exerted by this second spring is greater than the force exerted by the spring 70 , such that re-arming is done automatically, first by returning the actuating button 35 to its rest position, and also by returning the two support members 40 , 50 to their respective rest positions, by refilling the spring 70 .
  • the device according to the invention improves the dispensing of the fluid product into the nostril, by enabling the product to reach portions farthest away, such as the ethmoids.
  • the device according to the invention is, in particular, suitable for being used in the treatment of allergic rhinitis and central pain syndrome.
  • the fluid product can be chosen from the list below, given as a non-limiting example: fluticasone, mometasone, fluticasone furoate, budesonide, beclometasone, azelastine fluticasone, azelastine, tixocortol, triamcinolone acetonide, ipratropium bromide, prednisolone, ciclesonide, flunisolide, levocabastine, azelastine fluticasone furoate, olopatadine, azelastine mometasone, mometasone olopatadine, fluticasone olopatadine.
  • the fluid product can be chosen from the list below, given as a non-limiting example: sumatriptan, zolmitriptan, naloxone, fentanyl, esketamine, midazolam, butorphanol, dihydroergotamine, diazepam, tapentadol, alfentanil, diamorphine, ketorolac.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US18/572,363 2021-07-05 2022-07-04 Device for nasal delivery of a fluid product Pending US20240277954A1 (en)

Applications Claiming Priority (3)

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FRFR2107264 2021-07-05
FR2107264A FR3124735B1 (fr) 2021-07-05 2021-07-05 Dispositif de distribution nasale de produit fluide
PCT/FR2022/051324 WO2023281194A1 (fr) 2021-07-05 2022-07-04 Dispositif de distribution nasale de produit fluide

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MX2018012967A (es) 2016-04-25 2019-03-06 Koska Family Ltd Sistema de suministro medico.
KR102639913B1 (ko) 2017-11-17 2024-02-23 코스카 패밀리 리미티드 유체 전달 매니폴드를 위한 시스템 및 방법
US12544511B2 (en) 2018-06-20 2026-02-10 Koska Family Limited Systems and methods for pre-filled dual-chamber medical agent delivery
USD1052082S1 (en) 2020-06-01 2024-11-19 Koska Family Limited Sealed fluid container

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GB9705657D0 (en) * 1997-03-19 1997-05-07 Bacon Raymond J Dispenser
WO1999046055A1 (fr) 1998-03-10 1999-09-16 Valois S.A. Reservoir, procede de remplissage du reservoir et dispositif de distribution du produit fluide contenu dans le reservoir
FR2817847B1 (fr) 2000-12-08 2003-03-28 Tebro Dispositif de distribution de produit fluide ou pulverulent
US11992604B2 (en) * 2014-11-09 2024-05-28 Sipnose Ltd. Devices and methods for delivering a substance to a body cavity
CN113226418B (zh) * 2018-10-23 2023-12-01 阿克提夫阿克斯公司 鼻内压力药物递送设备
EP3914325B1 (fr) 2019-01-24 2024-04-24 Eli Lilly And Company Dispositifs d'administration de médicament par voie nasale

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CN117545523A (zh) 2024-02-09
EP4366802B1 (fr) 2025-09-03
EP4366802A1 (fr) 2024-05-15
FR3124735B1 (fr) 2023-06-16
FR3124735A1 (fr) 2023-01-06
WO2023281194A1 (fr) 2023-01-12

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