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US20190076391A1 - Methods of Subtyping CRC and their association with Treatment of Colon Cancer Patients With Oxaliplatin - Google Patents

Methods of Subtyping CRC and their association with Treatment of Colon Cancer Patients With Oxaliplatin Download PDF

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US20190076391A1
US20190076391A1 US16/184,748 US201816184748A US2019076391A1 US 20190076391 A1 US20190076391 A1 US 20190076391A1 US 201816184748 A US201816184748 A US 201816184748A US 2019076391 A1 US2019076391 A1 US 2019076391A1
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Katherine Lea Pogue-Geile
Nan Song
Soonmyung Paik
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Definitions

  • High risk stage II includes patients with perforation, or obstruction or tumors with lymphovascular or perineural invasion, T4 lesions, less than 12 Lymph nodes examined, or grade 3-4 lesions.
  • MOSAIC analysis found no statistically significant benefit for either all stage II or high risk stage II patients (Tournigand, Andre et al. 2012) 3 .
  • the use of oxaliplatin in all early stage colon cancer patients remains controversial not only because it is uncertain which patients actually receive benefit but also because of the toxic side effects associated with oxaliplatin (Cersosimo 2005) 4 . Thus, stratifying patients with regard to their oxaliplatin benefit is of significant clinical interest.
  • the current disclosure can be described therefore as a method for treating colon cancer in a patient in need thereof said method comprising obtaining a tumor tissue sample from said patient; determining a gene expression signature of said sample; identifying a tumor tissue subtype from said gene expression signature; and administering oxaliplatin when the identified tumor tissue subtype is an oxaliplatin responsive subtype.
  • subtype can refer to one of five colon cancer subtypes, enterocyte, TA, goblet, inflammatory and stem-like
  • sub-subtype can refer to a division within one of the 5 subtypes that is more enterocyte-like or that is more responsive to oxaliplatin, for example, than other genes within the subtype.
  • the methods can be further described therefore as determining a gene expression signature by steps including contacting a genetic sample from the tumor tissue sample with a plurality of specific genetic sequence binding targets and measuring the amount of genetic material expressed by the tumor tissue for a panel of selected genes, wherein the panel of genes are selected from those listed in Table 5.
  • a gene binding target can be a polynucleotide, a protein, a peptide or a peptide nucleic acid, and as such can be synthesized based on a complementary sequence or on a synthetic molecule designed to specifically bind to the RNA.
  • the sample or the target can be affixed to a solid surface such as a planar surface, contained in or affixed to a bead or contained in an oil droplet, for example, or in other forms known in the art such as but not limited to next-generation sequencing technologies such as RNA-Seq or whole transcriptome sequencing.
  • the genetic sample comprises degraded or intact RNA and can be mRNA or total RNA or whole tissue lysates from selected genes from Table 5.
  • the panel of genes for determination of a gene signature are selected by a process that includes Weighted Gene Correlation Network Analysis (WGCNA), to identify members of oxaliplatin responsive gene modules.
  • WGCNA Weighted Gene Correlation Network Analysis
  • Disclosed methods of treatment include administration of oxaliplatin is administered in combination with 5-fluorouracil plus leucovorin (FULV), and can include administration to a stage II or stage III colon cancer patient.
  • the tumor sample can be subtype enterocyte or TA or a sub-subtype of enterocyte or TA.
  • cancer tumor sample is subtype stem-like or a sub-subtype of stem-like.
  • the disclosure can also be described in certain embodiments as method for treating colon cancer in a patient in need thereof said method comprising: obtaining a tumor tissue sample from said patient; isolating RNA from the tumor tissue sample; contacting the RNA sample with a plurality of sequence specific probes effective to determine levels of expression of a panel of selected genes in the tumor sample to obtain a gene signature; identifying a colon cancer subtype or sub-subtype tumor subtype based on the gene signature; and administering oxaliplatin or causing oxaliplatin to be administered to said patient when the cancer subtype or sub-subtype is an oxaliplatin responsive subtype or sub-subtype.
  • Gene specific probes can include complementary nucleic acid sequences or other probes that do not necessarily bind to a site within the gene such as those used for Next-generation sequencing technologies which quantitate RNA by sequencing RNA molecules directly, for example.
  • the method can include utilizing a panel of selected genes are selected from the genes listed in Table 5.
  • the methods can further include administering oxaliplatin or causing oxaliplatin to be is administered in combination with 5-fluorouracil plus leucovorin (FULV) to a stage II or stage III colon cancer patient, where the patient's tumor tissue is determined to be subtype enterocyte or TA or a sub-subtype of enterocyte or TA, or subtype stem-like or a sub-subtype of stem-like.
  • FULV 5-fluorouracil plus leucovorin
  • FIG. 1 Design of Study for discovery and validation of a signature to identify patients who will benefit from oxaliplatin. In this description only the discovery cohort has been used for signature development.
  • FIG. 2 shows the steps that were taken to develop predictive algorithm using nCounter data from the discovery cohort of C-07.
  • FIG. 3 Kaplan Meier Plots of each CRC subtype using our gene signature by CRC-SSP-72 according to treatment (FULV versus FOLFOX) using recurrence free survival (RFS) as the end point.
  • FRS recurrence free survival
  • FIG. 5 Reproducibility of a C07 sample (C-07-0286) measured by nCounter. This sample was tested using 100, 150, 200, and 250 ng of total RNA as input.
  • FIG. 6 Venn diagram of genes used for developing subtype classifiers.
  • the present invention provides methods for identifying tumors which are responsive to oxaliplatin in individuals.
  • the methods involves the gene expression analysis of RNA isolated from tissue or other biological sources such as blood, urine or feces using nCounter Assays from Nanostring Technologies Inc, or other gene expression methodologies such as microarray, RNA-Seq, hybrid capture RNA sequencing or other state of the art RNA expression profiling methodologies, identifying the colon cancer intrinsic subtypes, identifying the subtypes that received benefit from oxaliplatin.
  • isolated RNA is meant to convey any separation of RNA from its environment in a cell, including any fractionation, binding, filtration, degradation or even cell rupture such as a lysate.
  • Samples used in this disclosure were from NSABP clinical trial C-07. This trial enrolled patients between February 2000 and November 2002 to compare oxaliplatin and bolus 5-FU/LV to bolus 5 FU/LV alone for resected stage II and III colon cancer 2 . C-07 was approved by an Institutional Review Board and informed consent was obtained from each subject for biomedical research.
  • RNAs isolated from tumors collected in NSABP clinical trial C-07 which is an ideal platform for a clinical assay for chemically modified and degraded RNAs isolated from FFPE because it requires no enzymology, requires small amounts of total RNA, capture and detection probes target less than 100 bp sequence, and the process is largely automated requiring little hands on time.
  • the C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes.
  • the 296 genes included in this nCounter code set were selected for the following reasons; the genes were prognostic or predictive for oxaliplatin benefit in the C-07 discovery cohort using whole genome DASL arrays (WG_DASL) from Illumina Inc or were part of significant pathways identified in C07 DASL data analysis or were from the literature or other internal data.
  • WG_DASL whole genome DASL arrays
  • subtype can be identified with a subset of 786 genes. Based on the 56 genes, using SSP method, specifically, we checked the Spearman correlation between each sample and the subtype centroid, and then assigned each sample to the subtype to which it was most correlated. This method correctly identified subtype in 79% of the samples.
  • centroid for each subtype based on the 72 genes that overlap between C-07 nCounter code dataset and the original CRC training dataset.
  • SSP method to the C-07 training dataset, i.e., we checked the Spearman correlation between each sample and the subtype centroid using the 72 genes (Table 1), then assigned each sample to the most correlated subtypes.
  • Table 2 Clinical variables such as T stage, nodal status perforation and mutation status of BRAF, KRAS, NRAS and PIK3CA of each subtype are shown in Table 3.
  • CCS colon cancer subtypes which include CCS1, CCS2 and CCS3 7 .
  • CRC clustering and CCS clustering are correlated with each other, i.e., most CCS1 patients are TA or Enterocyte patients, most CCS2 patients are inflammatory and most CCS3 are stem-like patients. Since CCS did not separate Enterocyte which received significant benefit from oxaliplatin from other TA patients, we decided to use SSP-72 to identify CRC subtypes.
  • the nCounter platform was selected as the platform for a clinical assay for degraded RNAs isolated from FFPE because it requires no enzymology, requires only 100 to 300 ng of total RNA, capture and detection probes target less than 100 bp sequences, and the process is largely automated requiring little hands on time.
  • the C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes. The 296 genes included in this nCounter code set were selected for the following reasons; the genes were prognostic or predictive for oxaliplatin benefit in the C07 discovery cohort using DASL data or were part of significant pathways identified in C07 DASL data analysis or were from the literature.
  • the enterocyte subtype in CRCA subtype received benefit from oxaliplatin; however, this signature failed to validate in the independent data set.
  • One reason that the signature failed to validate may be due to the non-optimal identification of the enterocyte subtype.
  • Our nCounter code set was created before the CRCA subtypes were described and therefore was not designed for subtype identification and unfortunately only includes a very small number of genes for enterocyte identification. Thus accurate identification of the enterocyte subtype was not optimal with the current code set
  • TA is a heterogeneous group which has a gene expression pattern similar to transit-amplifying progenitor cells which differentiate into goblet and enterocyte cells in the normal colonic crypt.
  • TA may be further refined into sub-subtypes based on their future potential fate, i.e., TA cells that are more likely to differentiate into enterocytes and those that differentiate into goblet. We would hypothesize that only the enterocyte-like subtype within TA would receive benefit from oxaliplatin.
  • nCounter code set only includes a small number of genes for enterocyte and goblet-like identification, we could not exploit this hypothesis in the nCounter data. We also attempted to split the stem-like subtype but were unable to find a satisfactory split for oxaliplatin benefit in this subtype.
  • WGCNA Weighted Gene Correlation Network Analysis
  • the original training dataset for CCS and CCMS includes 90 and 566 patients respectively.
  • Note the original CRCA training dataset is the combination of two datasets, to avoid the impact of batch effect, in our analyses; we analyzed the two datasets for CRCA analysis separately.
  • the yellow module includes 613 genes, overexpressed in TA/ccs1/CCMS1/CCMS5.
  • the green module includes 506 genes, doesn't seem to have a clear pattern.
  • the red module includes 452 genes, overexpressed in goblet/CCM3, enterocyte/CCMS6.
  • the data shows significant overlap among modules from other datasets, especially for turquoise and black modules identified from CCMS dataset.
  • brown, yellow and red modules identified in CCMS dataset they are moderately preserved in other datasets, and sometimes they were further split into smaller modules.
  • brown module in CCMS dataset split into both brown and green modules.

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Abstract

A gene expression signature identifies stage II colon and/or Stage III cancer patients who will receive benefit from oxaliplatin. Oxaliplatin has been shown to lengthen the survival of colon cancer patients, when it is combined with 5-fluorouracil plus leucovorin (FULV) in NSABP clinical trial C-07. Gene expression signatures are used first to classify tumors with regard to their respective subtypes, enterocyte, TA, goblet, inflammatory and stem-like and detection of expression of the enterocyte subtype directs treatment of the patient with oxaliplatin.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation of and claims the benefit of priority of U.S. patent application Ser. No. 14/738,757, filed Jun. 12, 2015, and further claims benefit of priority to U.S. provisional patent application Ser. No. 62/011,571 filed Jun. 12, 2014, the entire contents of both of which are incorporated herein by reference for all purposes.
    • BACKGROUND
  • Clinical trials MOSAIC (Andre, Boni et al. 2009)1 (Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin trial) and C-07 (Kuebler, Wieand et al. 2007)2 showed that oxaliplatin added to fluorouracil (FU) and leucovorin (LV) significantly improved disease free survival (DFS) and established oxaliplatin as part of the standard of care for the adjuvant treatment of early-stage colon cancer. In the C-07 trial, 2,409 patients diagnosed with stage II and III colon adenocarcinoma who had undergone potentially curative surgical resection with no evidence of residual malignant disease were randomly assigned to receive either FULV (FU 500 mg/m2 by intravenous [IV] bolus weekly for 6 weeks; leucovorin 500 mg/m2 IV weekly for 6 weeks of each 8-week cycle for three cycles) or FLOX (FULV plus oxaliplatin 85 mg/m2 IV on days 1, 15, and 29 of each cycle). Based on the 2011 analysis with median follow-up of 8 years, FLOX demonstrated superior DFS (HR: 0.82; P=0.002)(Kuebler, Wieand et al. 2007)2. Current NCCN guidelines recommend that all stage III patients, and high risk stage II patients be treated with oxaliplatin. High risk stage II includes patients with perforation, or obstruction or tumors with lymphovascular or perineural invasion, T4 lesions, less than 12 Lymph nodes examined, or grade 3-4 lesions. However, recent analysis of MOSAIC analysis found no statistically significant benefit for either all stage II or high risk stage II patients (Tournigand, Andre et al. 2012)3. The use of oxaliplatin in all early stage colon cancer patients remains controversial not only because it is uncertain which patients actually receive benefit but also because of the toxic side effects associated with oxaliplatin (Cersosimo 2005)4. Thus, stratifying patients with regard to their oxaliplatin benefit is of significant clinical interest.
  • Recently, several studies (De Sousa, Wang et al. 2013; Marisa, de Reynies et al. 2013; Sadanandam, Lyssiotis et al. 2013)6-8 have used unsupervised clustering methods to develop genomic signatures to classify colorectal cancer to different intrinsic subtypes and showed that each subtype has distinct molecular features, clinical significance and prognosis. These groups identified either 3 or 5 intrinsic subtypes with the CCS3, Stem-Like as the poorest prognostic group. The different number of clusters in these publications is not surprising given that different methods and different training datasets were used. Sadanandam et al's (Sadanandam, Lyssiotis et al. 2013)9 five subtypes were correlated to gene expression patterns of the different cell types located within the normal colonic crypts. De Sousa et al also demonstrated that most of the published gene expression based prognostic assays identify essentially the same group of tumors (mostly stem-like or CCS3 subtypes) as those associated with high risk of relapse. Given that it is now well established that breast cancer subtypes differ regarding their prognosis and their response to treatment, it was reasonable to hypothesize that the clinical behavior of the different colon subtypes may also differ with respect to prognosis and importantly with response to treatment. However, it was not possible to test treatment response in these published studies because the patient cohorts were treated with a variety of agents and were not part of a randomized clinical trial designed to test a particular agent. In contrast the gene expression data which was profiled on archived tumor blocks from NSABP clinical trial C-07 represented an ideal experimental cohort to test whether colon cancer subtypes could be used to predict oxaliplatin benefit. Before the publication of these colon cancer subtypes we had completed the gene expression profiling of 1846 patients from C-07 using our custom nCounter code set using nCounter assays from Nanostring Technologies.
    • SUMMARY
  • The initial study described here provides a gene expression signature which identifies stage II and III colon cancer patients who will receive benefit from oxaliplatin. Oxaliplatin has been shown to lengthen the survival of colon cancer patients, when it is combined with 5-fluorouracil plus leucovorin (FULV) in NSABP clinical trial C-07. However, mounting evidence suggest that not all early stage colon cancer patients benefit from oxaliplatin treatment and the toxicities associated with oxaliplatin highlights the importance of identifying patients who will actually receive benefit from oxaliplatin treatment. We have used gene expression signatures to first classify tumors in C-07 with regard to their respective subtypes, enterocyte, TA, goblet, inflammatory and stem-like and shown that only the enterocyte subtype received benefit from oxaliplatin. Comparing the benefit in the enterocyte subtype to a second group consisting of all four other subtypes, (Goblet-like, Inflammatory, Stem-like and TA) as a non-benefit group, showed a significant treatment-group interaction (p=0.012). In a second step we showed that the stem-like subtype can be further sub-typed into patients who do and do not receive benefit from oxaliplatin. Identification of this sub-subtype which received benefit from oxaliplatin is also of clinical interest in that the stem-like subtype has a very poor prognosis.
  • We have profiled 296 genes in 1840 patients from NSABP clinical trial C-07 using a custom nCounter code set using the nCounter Assay system from Nanostring Technologies (Seattle Wash.). Genes selected for inclusion on our custom nCounter code set were a result of our own gene expression analysis of the C-07 discovery cohort or other published studies. Gene expression profiling was conducted on tumor blocks from patients with follow-up information and proper consent. Samples within C-07 were split into non-overlapping discovery (N=848) and validation cohorts (N=992). The current description involves only the use of the discovery cohort. Clinical data and nCounter data for the discovery dataset were merged and anonymized by the honest broker at the University of Pittsburgh as defined by standard operations under IRB approval of the NSABP Biospecimen Bank and Biostatistics Center.
  • We have developed a predictive algorithm to classify tumors into oxaliplatin benefit or no benefit group using discovery cohort of 848 patients without access to the data from the remaining 992 patients (validation cohort). The nCounter genes used for this analysis are 72 genes included in both our custom nCounter code set (N=296) and in the intrinsic subtype signature described by Sadanandam et al. (Sadanandam, Lyssiotis et al. 2013)
  • The current disclosure can be described therefore as a method for treating colon cancer in a patient in need thereof said method comprising obtaining a tumor tissue sample from said patient; determining a gene expression signature of said sample; identifying a tumor tissue subtype from said gene expression signature; and administering oxaliplatin when the identified tumor tissue subtype is an oxaliplatin responsive subtype. As used herein subtype can refer to one of five colon cancer subtypes, enterocyte, TA, goblet, inflammatory and stem-like, and sub-subtype can refer to a division within one of the 5 subtypes that is more enterocyte-like or that is more responsive to oxaliplatin, for example, than other genes within the subtype.
  • The methods can be further described therefore as determining a gene expression signature by steps including contacting a genetic sample from the tumor tissue sample with a plurality of specific genetic sequence binding targets and measuring the amount of genetic material expressed by the tumor tissue for a panel of selected genes, wherein the panel of genes are selected from those listed in Table 5. A gene binding target can be a polynucleotide, a protein, a peptide or a peptide nucleic acid, and as such can be synthesized based on a complementary sequence or on a synthetic molecule designed to specifically bind to the RNA. The sample or the target can be affixed to a solid surface such as a planar surface, contained in or affixed to a bead or contained in an oil droplet, for example, or in other forms known in the art such as but not limited to next-generation sequencing technologies such as RNA-Seq or whole transcriptome sequencing.
  • In certain preferred embodiments the genetic sample comprises degraded or intact RNA and can be mRNA or total RNA or whole tissue lysates from selected genes from Table 5. In certain embodiments the panel of genes for determination of a gene signature are selected by a process that includes Weighted Gene Correlation Network Analysis (WGCNA), to identify members of oxaliplatin responsive gene modules.
  • Disclosed methods of treatment include administration of oxaliplatin is administered in combination with 5-fluorouracil plus leucovorin (FULV), and can include administration to a stage II or stage III colon cancer patient. The tumor sample can be subtype enterocyte or TA or a sub-subtype of enterocyte or TA. In certain embodiments cancer tumor sample is subtype stem-like or a sub-subtype of stem-like.
  • The disclosure can also be described in certain embodiments as method for treating colon cancer in a patient in need thereof said method comprising: obtaining a tumor tissue sample from said patient; isolating RNA from the tumor tissue sample; contacting the RNA sample with a plurality of sequence specific probes effective to determine levels of expression of a panel of selected genes in the tumor sample to obtain a gene signature; identifying a colon cancer subtype or sub-subtype tumor subtype based on the gene signature; and administering oxaliplatin or causing oxaliplatin to be administered to said patient when the cancer subtype or sub-subtype is an oxaliplatin responsive subtype or sub-subtype. Gene specific probes can include complementary nucleic acid sequences or other probes that do not necessarily bind to a site within the gene such as those used for Next-generation sequencing technologies which quantitate RNA by sequencing RNA molecules directly, for example.
  • The method can include utilizing a panel of selected genes are selected from the genes listed in Table 5. The methods can further include administering oxaliplatin or causing oxaliplatin to be is administered in combination with 5-fluorouracil plus leucovorin (FULV) to a stage II or stage III colon cancer patient, where the patient's tumor tissue is determined to be subtype enterocyte or TA or a sub-subtype of enterocyte or TA, or subtype stem-like or a sub-subtype of stem-like.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present inventions. The disclosure can be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.
  • FIG. 1 Design of Study for discovery and validation of a signature to identify patients who will benefit from oxaliplatin. In this description only the discovery cohort has been used for signature development.
  • FIG. 2 shows the steps that were taken to develop predictive algorithm using nCounter data from the discovery cohort of C-07.
  • FIG. 3 Kaplan Meier Plots of each CRC subtype using our gene signature by CRC-SSP-72 according to treatment (FULV versus FOLFOX) using recurrence free survival (RFS) as the end point. Among identified CRC subtypes, only Enterocyte received significant benefit (HR=0.315, p=0.005).
  • FIG. 4 Kaplan Meier Plots of the Enterocyte subtype and of all of the other subtypes (Goblet-like, Inflammatory, Stem-like and TA) combined into one group (Others) There is significant treatment-group interaction (p=0.012)
  • FIG. 5 Reproducibility of a C07 sample (C-07-0286) measured by nCounter. This sample was tested using 100, 150, 200, and 250 ng of total RNA as input.
  • FIG. 6 Venn diagram of genes used for developing subtype classifiers.
    •  DETAILED DESCRIPTION
  • The present invention provides methods for identifying tumors which are responsive to oxaliplatin in individuals. The methods involves the gene expression analysis of RNA isolated from tissue or other biological sources such as blood, urine or feces using nCounter Assays from Nanostring Technologies Inc, or other gene expression methodologies such as microarray, RNA-Seq, hybrid capture RNA sequencing or other state of the art RNA expression profiling methodologies, identifying the colon cancer intrinsic subtypes, identifying the subtypes that received benefit from oxaliplatin. As used herein isolated RNA is meant to convey any separation of RNA from its environment in a cell, including any fractionation, binding, filtration, degradation or even cell rupture such as a lysate.
  • Clinical Samples and Histological Evaluation Used in this Description.
  • Samples used in this disclosure were from NSABP clinical trial C-07. This trial enrolled patients between February 2000 and November 2002 to compare oxaliplatin and bolus 5-FU/LV to bolus 5 FU/LV alone for resected stage II and III colon cancer2. C-07 was approved by an Institutional Review Board and informed consent was obtained from each subject for biomedical research.
  • I. nCounter Assays Used to Determine Gene Expression
  • The nCounter platform by Nanostring Technologies was used to profile gene expression in RNAs isolated from tumors collected in NSABP clinical trial C-07 which is an ideal platform for a clinical assay for chemically modified and degraded RNAs isolated from FFPE because it requires no enzymology, requires small amounts of total RNA, capture and detection probes target less than 100 bp sequence, and the process is largely automated requiring little hands on time.
  • The C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes. The 296 genes included in this nCounter code set were selected for the following reasons; the genes were prognostic or predictive for oxaliplatin benefit in the C-07 discovery cohort using whole genome DASL arrays (WG_DASL) from Illumina Inc or were part of significant pathways identified in C07 DASL data analysis or were from the literature or other internal data.
  • We have profiled 296 genes in 1840 patients using the nCounter Assay system (Nanostring Technologies, Seattle Wash.). Clinical data and nCounter data for the discovery dataset were merged and anonymized by the honest broker at the University of Pittsburgh as defined by standard operations under IRB approval of NSABP Biospecimen Bank and Biostatistics Center. We have developed a predictive algorithm to classify tumors into oxaliplatin benefit or no benefit group using discovery cohort of 848 patients without access to the data from the remaining 992 patients (validation cohort).
    • II. Study Design
  • For C07, 2409 patients were enrolled in C-07 and all cases with tumor blocks, proper consent, clinical follow-up information and sufficient RNA yields were used in this study (N=1840). These cases were split into a discovery (N=848) and a validation (N=992) cohort (FIG. 1). The present signature was developed with the discovery cohort.
  • A. Intrinsic Subtype and Oxaliplatin Benefit:
  • The steps for signature development are summarized in FIG. 2.
  • With the goal of developing genomic predictive biomarker for oxaliplatin benefit, we first identified intrinsic subtypes and tested oxaliplatin benefit in each subtype. The disclosed methods focused on the CRC intrinsic subtypes identified by Sadanandam6, and the CCS intrinsic subtypes identified by De Sousa7. Since nCounter assay was designed before the publication of the above papers, only a small proportion of intrinsic genes were matched to genes included in the nCounter assay. For example, for the CRC study6, among 1262 non-specific filtered genes, only 72 exist in the nCounter code dataset, and among 786 identified intrinsic subtyping genes, only 56 exist in the nCounter code dataset. Our analysis indicated that subtype can be identified with a subset of 786 genes. Based on the 56 genes, using SSP method, specifically, we checked the Spearman correlation between each sample and the subtype centroid, and then assigned each sample to the subtype to which it was most correlated. This method correctly identified subtype in 79% of the samples.
  • To improve the robustness of subtype identification, we redeveloped centroid for each subtype based on the 72 genes that overlap between C-07 nCounter code dataset and the original CRC training dataset. We then applied SSP method to the C-07 training dataset, i.e., we checked the Spearman correlation between each sample and the subtype centroid using the 72 genes (Table 1), then assigned each sample to the most correlated subtypes. We can correctly identify the subtype in 80% of the samples (Table 2). Clinical variables such as T stage, nodal status perforation and mutation status of BRAF, KRAS, NRAS and PIK3CA of each subtype are shown in Table 3.
  • TABLE 1
    Centroid of CRC-SSP-72.
    Enterocyte Goblet.like Inflammatory Stem-like TA
    AKAP12 −0.1564 −0.3258 −1.00E−04 0.6652 −0.1946
    ANKRD44 0.0701 −0.1685 0.2335 0.0874 −0.1798
    BGN −0.2625 −0.3363 0.1203 0.684 −0.2285
    BHLHE41 0.1079 0.075 0.0015 0.2663 −0.3092
    BMP7 −0.2046 −0.0645 −0.143 0.04 0.2408
    C8orf84 −0.4073 0.5791 −0.0724 −0.1541 0.0682
    CAB39L −0.0904 −0.2837 −0.4717 0.1316 0.4798
    CDKN2B 0.6162 −0.4035 −0.0118 0.222 −0.2867
    CKMT2 0.0206 −0.2473 −0.2254 −0.0649 0.3515
    COL11A1 −0.4436 −0.3797 0.189 0.7476 −0.1898
    COMP −0.4057 −0.202 −0.1175 0.7747 −0.1101
    CPE 0.091 0.1071 −0.4766 0.2741 0.0311
    CSGALNACT1 −0.2585 −0.0478 −0.0254 0.2363 0.0324
    CXCL10 −0.1897 −0.1776 0.7137 −0.0052 −0.302
    CXCL11 −0.203 −0.115 0.6691 −0.0649 −0.2545
    CXCL13 0.11 −0.2356 0.8126 −0.1015 −0.4541
    CXCL2 −0.1416 0.0466 0.1917 −0.2284 0.0826
    CXCL9 −0.2303 −0.2078 0.7334 −0.006 −0.2731
    CYP1B1 −0.3509 −0.242 0.0875 0.8449 −0.3248
    DAPK1 −0.2495 0.3342 0.3441 0.1757 −0.4336
    DCBLD2 −0.2662 −0.1791 0.1036 0.335 −0.0522
    DPEP1 −0.1993 0.0196 −0.4644 −0.0446 0.4881
    EPB41L4B 0.1808 −0.0063 −0.2888 −0.3419 0.3594
    ERAP2 −0.0712 0.0416 0.4002 −0.1821 −0.1445
    F5 −0.2002 0.0195 0.2094 −0.0196 −0.03
    FAP −0.2881 −0.2525 0.1586 0.6969 −0.301
    FGL2 0.1732 −0.1883 0.3211 0.1058 −0.3093
    FN1 −0.2859 −0.4114 0.1302 0.5476 −0.0764
    FNDC1 −0.2566 −0.3827 −0.0213 0.8409 −0.2125
    GBP1 −0.1684 −0.2325 0.6939 0.0308 −0.2952
    GBP4 −0.1999 −0.1174 0.7101 −0.1899 −0.1937
    GPX3 0.0253 −0.1816 −0.0432 0.4493 −0.203
    GRM8 −0.0273 −0.1092 −0.3808 −0.2021 0.5153
    GZMB −0.2513 −0.4275 0.3314 −0.167 0.2865
    HGD 0.2535 0.3355 −0.0656 −0.3365 −0.0593
    HOXA13 −0.0301 0.1091 −0.0917 −0.2152 0.1795
    HSD17B2 0.6687 −0.0054 0.1407 −0.3991 −0.2153
    ID4 −0.1789 0.0325 −0.2977 0.4248 0
    IDO1 −0.2064 −0.1664 0.7754 −0.2062 −0.1969
    IL8 −0.166 −0.0459 0.3226 0.0624 −0.156
    INHBA −0.3224 −0.2377 0.1021 0.6646 −0.2233
    MFAP5 1.00E−04 −0.3641 −0.1964 0.8067 −0.2264
    MGP 0.0509 −0.4134 −0.1745 0.8961 −0.3097
    MMP11 −0.1743 −0.2439 −0.1581 0.462 0.0318
    MMP28 0.4253 0.2425 0.1082 −0.1931 −0.3441
    NFIB 0.0535 −0.0317 −0.5168 0.0032 0.3672
    OAS2 −0.1136 0.0199 0.4392 −0.0611 −0.2234
    PAPPA −0.0641 −0.2033 0.0437 0.3593 −0.1342
    PIGR 0.2984 0.2771 0.2527 −0.4536 −0.2038
    PLA2G12B −0.0591 −0.2634 −0.3123 −0.1001 0.5015
    POU2AF1 0.3543 0.2138 0.147 −0.1889 −0.3155
    PRAP1 −0.0074 −0.2188 −0.4551 0.0767 0.4181
    PROM2 0.2046 0.1593 −0.0655 −0.2981 0.0462
    PSMB9 −0.1726 −0.0019 0.4983 −0.2105 −0.1072
    PTPRC 0.0416 −0.252 0.5649 0.1694 −0.4187
    ROBO1 −0.1221 −0.2991 0.0818 0.2661 −0.0014
    SDC2 −0.0982 −0.2924 −0.0399 0.5358 −0.1257
    SELL 0.0788 −0.1222 0.2456 0.0016 −0.1589
    SERPINE1 −0.1613 −0.116 0.0757 0.3678 −0.1574
    SFRP2 −0.2103 −0.5022 0.0497 1.0716 −0.3926
    SGK2 0.2445 −0.2138 −0.4084 −0.2707 0.4818
    SLC4A4 1.099 0.1349 0.0933 −0.461 −0.4826
    SPARC −0.1227 −0.3431 0.0146 0.6662 −0.218
    SPP1 −0.3134 −0.1681 0.4032 0.4321 −0.3238
    SSPN −0.0575 −0.0801 −0.1318 0.5308 −0.206
    STC1 −0.3185 −0.1163 0.2305 0.2822 −0.1135
    TACSTD2 −0.0954 0.2113 −0.0379 0.109 −0.1196
    TGFBR3 −0.1721 −0.0829 −0.016 0.04 0.1378
    TM4SF1 −0.1527 −0.1754 −0.0883 0.0963 0.1938
    TYMS −0.1895 0.1904 0.4728 −0.3805 −0.0701
    VCAN −0.1637 −0.3038 −0.0031 0.7104 −0.2344
    VNN1 0.0753 0.2341 0.4957 −0.2096 −0.4016
  • TABLE 2
    Consistency between CRC-SSP-72 and original
    algorithm in identifying CRC subtypes.
    Truth
    Goblet- Stem-
    Enterocyte like Inflammatory like TA
    Prediction Enterocyte
    40 0 0 0 4
    Goblet.like 5 42 2 0 3
    Inflammatory 11 9 68 2 4
    Stem-like 8 8 6 75 10
    TA 0 4 2 0 84
  • TABLE 3
    Patient characteristics by intrinsic subtype identified by CRC-SSP-72.
    Enterocyte Goblet-like Inflammatory Stem-like TA
    Gender F 43 (47.3%) 22 (34.9%)  89 (44.1%)  95 (39.7%)  79 (43.2%)
    M 48 (52.7%) 41 (65.1%) 113 (55.9%) 144 (60.3%) 104 (56.8%)
    Stage II 26 (28.6%) 20 (31.7%)  88 (43.6%)  57 (23.8%)  42 (23%)
    III 65 (71.4%) 43 (68.3%) 114 (56.4%) 182 (76.2%) 141 (77%)
    Grade Diff 80 (87.9%) 51 (81%) 126 (62.4%) 194 (81.2%) 168 (91.8%)
    undiff 11 (12.1%) 12 (19%)  76 (37.6%)  45 (18.8%)  15 (8.2%)
    TStage T12 15 (16.5%) 11 (17.5%)  17 (8.4%)  7 (2.9%)  28 (15.3%)
    T3 71 (78%) 46 (73%) 176 (87.1%) 213 (89.1%) 144 (78.7%)
    T4  5 (5.5%)  6 (9.5%)   9 (4.5%)  19 (7.9%)  11 (6%)
    Perforation 0 89 (97.8%) 62 (98.4%) 196 (97%) 231 (96.7%) 179 (97.8%)
    1  2 (2.2%)  1 (1.6%)   6 (3%)   8 (3.3%)   4 (2.2%)
    Nodes positive 0 26 (28.6%) 20 (31.7%)  88 (43.6%)  57 (23.8%)  42 (23%)
    detected 1-3 43 (47.3%) 32 (50.8%)  78 (38.6%) 107 (44.8%) 108 (59%)
    4+ 22 (24.2%) 11 (17.5%)  36 (17.8%)  75 (31.4%)  33 (18%)
    MSI status MSS 77 (100%) 50 (87.7%) 131 (72.4%) 193 (94.1%) 162 (97.6%)
    MSI  0 (0%)  7 (12.3%)  50 (27.6%)  12 (5.9%)  4 (2.4%)
    BRAFmutated w 83 (91.2%) 48 (78.7%) 145 (72.9%) 205 (86.1%) 177 (96.7%)
    m  8 (8.8%) 13 (21.3%)  54 (27.1%)  33 (13.9%)  6 (3.3%)
    KRASmutated w 64 (71.9%) 26 (44.1%) 129 (66.8%) 126 (54.1%) 121 (66.9%)
    m 25 (28.1%) 33 (55.9%)  64 (33.2%) 107 (45.9%)  60 (33.1%)
    METmutated w 85 (96.6%) 56 (94.9%) 184 (95.3%) 227 (97.4%) 174 (96.1%)
    m  3 (3.4%)  3 (5.1%)   9 (4.7%)   6 (2.6%)   7 (3.9%)
    NRAS mutated w 85 (96.6%) 56 (94.9%) 190 (99%) 226 (97%) 176 (97.2%)
    m  3 (3.4%)  3 (5.1%)   2 (1%)   7 (3%)   5 (2.8%)
    PIK3CAmutated w 74 (84.1%) 46 (76.7%) 142 (73.2%) 175 (74.8%) 158 (87.3%)
    m 14 (15.9%) 14 (23.3%)  52 (26.8%)  59 (25.2%)  23 (12.7%)
    RFI Status 0 59 (64.8%) 47 (74.6%) 173 (85.6%) 141 (59%) 132 (72.1%)
    1 32 (35.2%) 16 (25.4%)  29 (14.4%)  98 (41%)  51 (27.9%)
    OS Status 0 54 (59.3%) 40 (63.5%) 156 (77.2%) 138 (57.7%) 121 (66.1%)
    1 37 (40.7%) 23 (36.5%)  46 (22.8%) 101 (42.3%)  62 (33.9%)
  • As shown in FIG. 3, among identified CRC subtypes, only Enterocyte received significant benefit (HR=0.315, p=0.005). In combining all other four subtypes, Goblet-like, Inflammatory, Stem-like and TA as a non-benefit group, there is significant treatment-group interaction (p=0.012) (FIG. 4). However when stage II and III CRC patients were tested separately only stage III patients showed differential benefit from oxaliplatin when subtyped with our 72 gene signature (FIG. 5).
  • Similarly, we also identified CCS colon cancer subtypes which include CCS1, CCS2 and CCS37. Consistent with other studies11, the CRC clustering and CCS clustering are correlated with each other, i.e., most CCS1 patients are TA or Enterocyte patients, most CCS2 patients are inflammatory and most CCS3 are stem-like patients. Since CCS did not separate Enterocyte which received significant benefit from oxaliplatin from other TA patients, we decided to use SSP-72 to identify CRC subtypes.
  • III. RNA Expression Profiling Using nCounter Assay System
  • Gene Expression Profiling by nCounter Assay System:
  • The nCounter platform was selected as the platform for a clinical assay for degraded RNAs isolated from FFPE because it requires no enzymology, requires only 100 to 300 ng of total RNA, capture and detection probes target less than 100 bp sequences, and the process is largely automated requiring little hands on time. The C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes. The 296 genes included in this nCounter code set were selected for the following reasons; the genes were prognostic or predictive for oxaliplatin benefit in the C07 discovery cohort using DASL data or were part of significant pathways identified in C07 DASL data analysis or were from the literature.
  • nCounter Assay Data Processing
  • QC of the nCounter Assay Data.
  • Quality control of the data was performed using default flags in the NSolver software that is provided by the manufacturer:
      • 1) Imaging flag—sample removed if less than ¾ of the expected fields of view are captured by the camera (0.75*600=450 minimum FOVs)
      • 2) Binding Density—sample removed if the binding density falls outside the range 0.05-2.25
      • 3) Positive Control Flag—sample removed if the positive spikes do not follow the expected linear trend (r̂2<0.95)
      • 4) 0.5 fm Detection Flag—sample removed if the 0.5 fm positive control is within two standard deviations of the negative controls
      • 5) Tech Normalization Flag—for the raw data, median(sum(pos(controls))/sum(positive control); sample removed if the technological normalization factor >3 or <0.3
      • 6) Biological Normalization Flag—after adjusted by technical normalization, median (geomean(pos(house-keeping control s))/geomean(house-keeping control); sample removed if the biological normalization factor <0.1 or >10. In this data, KIAA1539, MADD, RAB1A, C17orf79, PDCD10, NFYC were selected as house-keeping genes.
      • 7) If repeated measurements for an individual both pass above criteria, the lane with the lesser total counts will be removed
  • With the above criteria, 778 out of 848 samples (91.75%) pass QC and were used for signature development.
    • 1. Nanostring Data Normalization
  • After preprocessing data, we normalized each tumor for technical variability with the sum of the positive controls inherent to nCounter assay and within sample reference normalized with the geometric mean of 6 internal reference genes (KIAA1539, MADD, RAB1A, C17orf79, PDCD10, NFYC).
  • 2. Analytical Performance of mRNA Expression Profile by nCounter:
  • Dynamic range and limit of detection for the nCounter assay can be estimated from synthetic spike-in controls included with every sample. Positive controls are spiked into the reaction at concentrations from 0.125-128 fM, representing a fold-change of 1024. Measurements of these controls are highly linear (median r2=0.99 across all discovery samples) in this range. Eight negative control probes, representing sequences not found in the human transcriptome, are also included in each reaction. The lowest positive control, 0.125 fm, represents approximately 0.2 copies per cell, and is detected at least 2 standard deviations above the mean of the negative controls. If r2 for the positive spikes drops below 0.95 or the 0.125 fm spike is not detected 2 standard deviations above the mean of the negative controls, the reaction is considered failed and that sample is repeated or removed from further analysis.
  • We also tested 11 pairs of samples as duplicate. For these duplicate samples, we calculated the correlation coefficients for the gene expression, the minimum of correlation coefficient is 0.9912, and mean is 0.9925, standard deviation is 0.0021.
  • To address assay reproducibility and required amount of input RNA, we first performed several samples using 100, 150, 200, and 250 ng of total RNA as input. Results for one representative sample are shown in FIG. 5. The raw data demonstrates an almost linear increase in signal with increased input material. However, normalized data were nearly identical demonstrating that we can use 100 ng of total RNA as the starting material for the nCounter assay.
  • In the C-07 discovery cohort the enterocyte subtype in CRCA subtype received benefit from oxaliplatin; however, this signature failed to validate in the independent data set. One reason that the signature failed to validate, may be due to the non-optimal identification of the enterocyte subtype. Our nCounter code set was created before the CRCA subtypes were described and therefore was not designed for subtype identification and unfortunately only includes a very small number of genes for enterocyte identification. Thus accurate identification of the enterocyte subtype was not optimal with the current code set
  • Another potential problem that may have contributed to the failure to validate our signature was the possibility that other subtypes could include patients who benefited from oxaliplatin. For example the stem-like and TA subtypes may need to be further split into sub-subtypes. TA is a heterogeneous group which has a gene expression pattern similar to transit-amplifying progenitor cells which differentiate into goblet and enterocyte cells in the normal colonic crypt. Thus TA may be further refined into sub-subtypes based on their future potential fate, i.e., TA cells that are more likely to differentiate into enterocytes and those that differentiate into goblet. We would hypothesize that only the enterocyte-like subtype within TA would receive benefit from oxaliplatin. However, because our nCounter code set only includes a small number of genes for enterocyte and goblet-like identification, we could not exploit this hypothesis in the nCounter data. We also attempted to split the stem-like subtype but were unable to find a satisfactory split for oxaliplatin benefit in this subtype.
  • As discussed above, the basis of our previous work is that subtypes have different molecular properties, which determine the degree of benefit they receive from treatment. However, because the identification of CRC subtypes is still in an exploratory phase, it is uncertain how to best identify relevant subtypes for oxaliplatin benefit.
  • Disclosed herein are a description of the genes and methods for identifying the association of gene modules with CRC subtypes and their association with clinical behavior with an emphasis on identifying patients who receive benefit from oxaliplatin. Identification of modular gene sets and their association to particular CRC subtypes allows not only for subtype identification but also a description of those subtypes, how they are similar and how they are different which will enable a better understanding of clinical behavior.
  • In the second study, we took a well-established systematic approach, Weighted Gene Correlation Network Analysis (WGCNA), to identify gene modules, i.e., correlated gene expression networks and evaluated how these modules are related to subtypes. Gene modules are generally comprised of functionally related genes. Understanding the gene modules which characterize subtypes will enable us to understand how each subtype is correlated to each other, and the molecular mechanisms of different prognostic or predictive behavior of each subtype. We have selected genes for a new code set which will enable us to better identify functional, clinically relevant CRC subtypes.
  • Additional studies profile C-07 with this new code set which provides better understanding of how each module is related to oxaliplatin benefit. Then we reevaluate which current subtype system (among CCS, CRCA, CCMS) is the best for identifying patients that will get benefit from oxaliplatin, or we develop a better classification system to define subtypes in terms of oxaliplatin benefit. In addition, we also develop signatures based on other approaches by combining information obtained from gene module analyses.
    • Study Design II
  • We have downloaded the original training datasets for CCS, CCMS and CRCA classifier. The original training dataset for CCS and CCMS includes 90 and 566 patients respectively. Note the original CRCA training dataset is the combination of two datasets, to avoid the impact of batch effect, in our analyses; we analyzed the two datasets for CRCA analysis separately.
  • For each dataset, we performed WGCNA analysis on the genes used for the specific classifier. In addition, although these three classifiers all started with genes having large variance, the list of genes is different (FIG. 2). We also performed WGCNA analysis on the union of genes used for all three classifiers (4510). A Venn diagram of genes used for developing subtype classifiers appear in FIG. 6.
  • WGCNA constructed a network using adjacency matrix, which is constructed by using the soft-threshold approach (13=8) on the matrix of pair-wise correlation coefficients. Topological overlap distance was then calculated from the adjacency matrix, and used to build a hierarchical clustering tree. Modules were defined as branches of a hierarchical clustering tree, with a minimum module size of 50 genes. A module eigengene distance threshold of 0.4 was also used to merge highly similar modules. Each module is assigned a unique color label. For the convenience of comparison, we matched the module colors from different training dataset based on modules identified in CCMS training dataset. WGCNA analysis was done using WGCNA R package
  • We assigned each patient to different subtype in CCS, CRCA or CCMS clustering system using SSP method, the centroid was obtained from the original publications. We further identified differentially expressed genes for each subtype using SAM method, and plotted such information underneath the WGCNA tree.
    • Results
  • For each dataset, we performed WGCNA analysis on the genes used for the specific classifier (data not shown) and the union of genes used for training three classifiers (4510 genes) in the WGCNA analysis in CCMS training datasets. The module colors are assigned by WGCNA algorithm automatically, based on the ranking of module size.
  • To understand how these modules are related to subtype, information of genes' expression in each subtype was added in the tree plot. In CCMS training dataset ( ), six large modules were identified, and these gene modules express differently in different subtypes. Turquoise module, the largest module, includes 1424 genes, and most of these over expressed in stem-like/ccs3/CCMS4 and CCMS6. Importantly, the turquoise module contains stromal and epithelial to mesenchymal related genes demonstrating the functional information that can be inferred with modular analysis. The black module includes 866 genes, they overexpressed in stem-like/ccs3/CCMS4, and inflammatory/ccs2/CCMS2. The brown module includes 649 genes, overexpressed in inflammatory/ccs/CCMS2. The yellow module includes 613 genes, overexpressed in TA/ccs1/CCMS1/CCMS5. The green module includes 506 genes, doesn't seem to have a clear pattern. The red module includes 452 genes, overexpressed in goblet/CCM3, enterocyte/CCMS6.
  • TABLE 4
    Goblet- Stem-
    # genes Enterocyte like Inflammatory like TA
    Turquoise 1424 +
    Black 866 + +
    Brown 649 +
    Yellow 613 +
    Green 506
    Red 452 + +
  • Similar analyses were performed for other datasets. For the convenience of comparison, we have matched the module color from other datasets to module colors in CCMS training dataset. As shown in FIG. 3B-D, although modules identified in other datasets are different from modules identified in CCMS training datasets, there is significant overlap for modules identified from different datasets, and these modules have distinct expression pattern in different subtypes.
  • To identify genes that are preserved in different datasets in terms of module membership, we further laid out the significant overlap modules identified in different datasets in the same tree, i.e., genes that are from modules that don't have significant overlap are colored gray.
  • The data (not shown) shows significant overlap among modules from other datasets, especially for turquoise and black modules identified from CCMS dataset. For brown, yellow and red modules identified in CCMS dataset, they are moderately preserved in other datasets, and sometimes they were further split into smaller modules. For example, in ccs datasets, the brown module in CCMS dataset split into both brown and green modules. Gene selection focuses on genes that are preserved in modules with particular focus on hub genes, i.e, genes which have strong correlation with a large number of genes.
  • We have identified a list of genes that will be used for identification of subtypes and sub-subtypes with differential benefit from oxaliplatin Table 6. Genes will be selected from this table to include in our code set to profile C-07. Further refinement of the code set will be determined by additional criteria such as a gene's correlation between fresh and FFPE isolated RNA, the preservation in other datasets, and functional analysis.
  • TABLE 5
    Genes for identification of subtypes and sub-subtypes
    CCMS ccs CRCA1 CRCA2 potential 1
    RGL3 black black black gray
    GABRB2 black gray black black
    ZDHHC11 turquoise gray gray gray
    HOTTIP black gray gray gray
    TCTE3 black gray black black
    FAM185A black gray black black
    NKAIN2 turquoise turquoise turquoise gray
    SV2C turquoise gray turquoise turquoise
    C17orf78 turquoise turquoise turquoise gray
    ERVMER34-1 turquoise turquoise turquoise turquoise
    ZNF395 turquoise gray gray gray
    NTRK2 brown gray gray gray
    SH3TC2 turquoise turquoise gray turquoise
    SLC7A8 turquoise gray gray turquoise
    LURAP1L turquoise gray gray turquoise
    EDAR turquoise turquoise turquoise turquoise
    SLC6A20 black gray gray gray
    FLVCR1-AS1 brown gray brown brown
    RUSC1-AS1 turquoise turquoise gray gray
    LCN15 turquoise gray gray gray
    PLEKHS1 black black black gray
    CLDN2 brown brown brown brown
    CYP4X1 brown green brown brown
    TRIB1 turquoise gray turquoise turquoise
    LSS brown green brown gray
    ZDHHC5 brown green gray gray
    LRRC8E brown green gray brown
    OTUB2 brown brown brown brown
    SCARNA2 yellow gray gray gray
    CAMTA1 brown gray gray gray
    IL1A black magenta gray black
    CCL20 yellow red green red
    NFKBIZ black black black black
    ZC3H12A black black black black
    CXCL1 black black black black
    CXCL2 black black black black
    CXCL3 brown brown gray gray
    C11orf71 black gray black black
    KRTAP4-1 yellow yellow yellow gray
    MACROD1 brown green gray gray
    SAMD12 turquoise gray gray turquoise
    GABRA2 turquoise gray gray turquoise
    IRS2 turquoise gray gray gray
    SLC44A5 green yellow gray red
    SEC16B green gray yellow gray
    DEPTOR turquoise turquoise gray turquoise
    EPPK1 brown green gray gray
    ALDH7A1 brown green gray gray
    UTS2 black gray black black
    MYCN brown gray brown brown
    CLCN4 black black black gray
    RGMB brown green brown gray
    NMNAT3 brown gray gray gray
    DCDC2 black gray gray gray
    HIPK2 black gray black gray
    ANKRD17 green green gray gray
    HINT3 turquoise gray gray turquoise
    AIG1 turquoise gray gray gray
    TPD52L1 brown gray gray gray
    ERO1L black magenta black gray
    SPTBN1 black gray black gray
    CD9 brown green gray gray
    ENC1 black gray gray gray
    DNAJC16 brown green gray gray
    NNT green green gray red
    LRRC6 brown gray gray gray
    NETO2 brown green brown brown
    STK31 green yellow yellow gray
    EPB41L2 green green gray gray
    SULT1C2 brown gray gray gray
    ANKRD18A brown gray gray brown
    SAMD5 brown gray brown brown
    NRD1 black gray black gray
    6-Mar turquoise gray gray turquoise
    PLCB1 green yellow yellow gray
    ZNF678 green yellow yellow red
    ZNF738 green gray gray gray
    ZNF702P green gray gray gray
    DEPDC7 green gray gray yellow
    ALPK1 green yellow gray gray
    FAM221A green gray gray red
    RBM11 green yellow gray red
    FAM213A green gray gray gray
    RHOBTB3 green yellow gray gray
    SLC22A15 green gray gray gray
    NT5C2 green yellow gray gray
    ZNF124 green gray yellow red
    KDM4C green green yellow red
    RALGPS1 green yellow yellow red
    TJP2 green yellow gray gray
    MBOAT2 green gray gray gray
    VEGFA green green gray gray
    ZNF320 green gray gray gray
    EEF1A1 green yellow gray gray
    TOB1 green yellow gray red
    PIK3R1 green yellow gray gray
    GK green gray gray gray
    MET green yellow gray gray
    ITPR2 green gray gray gray
    GRAMD1C green gray gray red
    DDX26B green gray gray gray
    PRRG1 green gray gray gray
    TAF9B green green yellow gray
    ZNF711 green gray gray gray
    ZNF614 green yellow gray red
    TRIM13 green yellow gray red
    ZNF652 green yellow gray gray
    ARID2 green yellow yellow red
    TIPRL green green yellow gray
    FAM92A1 green gray yellow gray
    SQLE green green yellow gray
    LACTB2 green green gray gray
    NUBPL green yellow yellow red
    PDE7A green green yellow yellow
    FAM84B green yellow yellow gray
    YWHAZ green green gray yellow
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    CDCA7L brown brown brown brown
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    PPID brown gray gray brown
    XRCC5 brown gray gray brown
    EIF4E brown green brown brown
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    SMS brown green brown brown
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    BICD1 brown gray gray brown
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    MTFMT brown green brown brown
    GNPNAT1 brown brown brown brown
    DNAAF2 brown green brown brown
    TMX1 brown green gray brown
    CAND1 brown gray gray brown
    RBBP8 brown brown gray brown
    RNF138 brown brown gray brown
    TIMM21 brown brown gray brown
    CHAC2 brown brown brown brown
    GEMIN2 brown brown brown brown
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    SEH1L brown brown brown brown
    GLE1 brown green brown brown
    SFXN1 brown brown brown brown
    SGOL1 brown gray brown brown
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    SET brown gray brown brown
    TRNT1 brown green brown brown
    PSPH brown green gray brown
    ACLY brown green brown gray
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    DIS3 brown gray gray brown
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    MZT1 brown brown gray brown
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    BORA brown brown gray brown
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    HNRNPC brown gray brown brown
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    LRP8 brown brown brown brown
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    C1orf174 brown green gray brown
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    CTNNAL1 brown brown brown brown
    TKT brown green brown brown
    MRPL50 brown green brown brown
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    TMEM237 brown gray brown gray
    NUP50 brown green brown brown
    FGFR1OP brown green brown brown
    SPIN4 brown gray gray brown
    NSMCE4A brown green brown brown
    NUP210 brown green brown brown
    UTP20 brown green brown brown
    WDR4 brown brown brown brown
    NUP62CL brown brown brown brown
    GAS2L3 brown brown brown brown
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    POLR3G brown brown brown brown
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    ADK brown green gray brown
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    HSPA9 brown green brown brown
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    RMI2 brown brown brown brown
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    SLC52A3 yellow red green red yellow
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    RAB11FIP1 yellow gray gray red yellow
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    GPR115 yellow yellow yellow gray yellow
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    IGF2R yellow gray yellow gray yellow
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    IGF2BP2 yellow yellow yellow yellow yellow
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    SCD yellow gray yellow gray yellow
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    PCLO yellow yellow yellow red yellow
    KAZN yellow yellow green yellow yellow
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    TP53TG1 yellow yellow yellow red yellow
    QPCT yellow yellow yellow red yellow
    ZNF827 yellow yellow yellow red yellow
    EIF3C yellow yellow yellow red yellow
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    RNF182 yellow yellow yellow yellow yellow
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    SOX9 yellow gray yellow red yellow
    HKDC1 yellow red yellow gray yellow
    RASSF10 yellow yellow yellow red yellow
    RAB11FIP3 yellow yellow yellow gray yellow
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    TNMD yellow yellow yellow gray yellow
    PVR yellow gray yellow red yellow
    ACOX2 yellow yellow green red yellow
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    MCF2L yellow yellow yellow yellow yellow
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    CCDC170 yellow yellow yellow red yellow
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    FOXQ1 yellow gray yellow yellow yellow
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    CGREF1 yellow yellow yellow yellow yellow
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    SLC11A2 yellow red yellow red yellow
    SLC13A2 yellow yellow green red yellow
    SH3BP4 yellow yellow yellow red yellow
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    MYO10 yellow yellow yellow red yellow
    MPC2 yellow gray green red yellow
    PCTP yellow yellow yellow red yellow
    HDHD1 yellow yellow yellow red yellow
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    FCGRT yellow yellow yellow gray yellow
    TMEM176A yellow gray yellow gray yellow
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    JUN yellow yellow yellow gray yellow
    FGFR3 yellow yellow green red yellow
    SDR42E1 yellow yellow green red yellow
    ALDH4A1 yellow yellow yellow gray yellow
    AZGP1 yellow yellow yellow yellow yellow
    RPS15A yellow yellow yellow gray yellow
    DENND1A yellow gray gray red yellow
    SLC22A3 yellow yellow yellow yellow yellow
    CHPT1 yellow yellow yellow red yellow
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    CAMK2N1 yellow yellow yellow yellow yellow
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    CXXC4 yellow yellow yellow gray yellow
    RAB40B yellow yellow gray red yellow
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    SLC35D3 yellow yellow yellow gray yellow
    IP6K2 yellow yellow yellow red yellow
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    UNC5CL yellow yellow yellow yellow yellow
    EVPL yellow yellow yellow red yellow
    SLC1A7 yellow yellow yellow red yellow
    ANKH yellow gray yellow red yellow
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    SHH yellow yellow green red yellow
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    AMT yellow yellow green gray yellow
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    MYO15B yellow yellow green red yellow
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    CGN yellow red green red yellow
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    CC2D1A yellow gray green red yellow
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    KLC4 yellow yellow yellow red yellow
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    PCK1 yellow red green red yellow
    SEMA6D yellow red green red yellow
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    SLC26A2 yellow red green red yellow
    TRPM6 yellow yellow green red yellow
    SORT1 yellow gray green red yellow
    ID1 yellow red green red yellow
    GPR39 yellow red yellow red yellow
    LEFTY1 yellow red green red yellow
    CKB yellow red green red yellow
    PAQR8 yellow red green red yellow
    KIAA1161 yellow red green red yellow
    OLFM4 yellow red green red yellow
    ZSWIM5 yellow red green red yellow
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    B3GNT3 yellow red green red yellow
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    PHYH yellow yellow green red yellow
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    KCNQ1 yellow yellow yellow red yellow
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    GALNT6 yellow yellow yellow red yellow
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    PTPRD yellow yellow green red yellow
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    LY75 yellow yellow yellow red yellow
    SEMA3C yellow yellow green gray yellow
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    IYD yellow yellow green red yellow
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    AUTS2 yellow yellow green red yellow
    DIAPH2 yellow yellow green yellow yellow
    PRLR yellow yellow yellow red yellow
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    FAM105A yellow red green red yellow
    SATB2-AS1 yellow yellow green red yellow
    PRKAB1 yellow red green red yellow
    HMGCS2 yellow red green red yellow
    CXCL14 yellow yellow green red yellow
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    HEPH yellow red green red yellow
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    LINC00483 yellow red green red yellow
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    ETS2 yellow gray green red yellow
    CASP6 yellow red green red yellow
    GLCE yellow yellow green red yellow
    PANK1 yellow red green red yellow
    GPX2 yellow yellow yellow red yellow
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    ST14 yellow red green red yellow
    PPARG yellow red green red yellow
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    SPINK1 yellow red green red yellow
    SGK2 yellow yellow green red yellow
    ACOX1 yellow yellow green red yellow
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    KALRN yellow red green red yellow
    MUC12 yellow yellow green red yellow
    KRT20 yellow red green red yellow
    PIGZ yellow red green red yellow
    NAT2 yellow red green red yellow
    FAM134B yellow red green red yellow
    PBLD yellow red green red yellow
    SELENBP1 yellow red green red yellow
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    SOWAHA yellow yellow green red yellow
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    TFCP2L1 yellow yellow green red yellow
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    EPS8L3 yellow red green red yellow
    CDH17 yellow red green red yellow
    CEACAM5 yellow red green red yellow
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    TMPRSS2 yellow red green red yellow
    A1CF yellow yellow green red yellow
    MUC20 yellow yellow green red yellow
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    TRABD2A yellow yellow green red yellow
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    ISX yellow yellow green red yellow
    ACE2 yellow yellow yellow red yellow
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    PPP1R14C yellow yellow green red yellow
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    DDC yellow yellow green red yellow
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    SLC26A3 yellow red green red yellow
    EPB41L4B yellow yellow green red yellow
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    C10orf99 yellow red green red yellow
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    IHH yellow yellow green red yellow
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    ATP10B yellow yellow green red yellow
    GPR160 yellow yellow green red yellow
    GUCY2C yellow yellow green red yellow
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    TMEM63A yellow gray yellow yellow yellow
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    STK24 yellow gray yellow yellow yellow
    CELSR3 yellow yellow yellow yellow yellow
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    KLHDC10 yellow gray yellow yellow yellow
    C20orf196 yellow yellow green red yellow
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    CCDC113 yellow yellow yellow red yellow
    GYLTL1B yellow yellow yellow gray yellow
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    MED1 yellow gray yellow yellow yellow
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    ATP6V1C2 yellow yellow yellow red yellow
    HILPDA yellow gray yellow gray yellow
    SLC2A12 yellow yellow yellow yellow yellow
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    FABP6 yellow yellow yellow red yellow
    PNLIPRP2 yellow yellow green red yellow
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    PPDPF yellow yellow yellow yellow yellow
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    TG yellow yellow yellow red yellow
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    AGT yellow yellow green gray yellow
    CYP4F2 yellow yellow yellow yellow yellow
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    FREM2 yellow yellow yellow yellow yellow
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    ESPN yellow yellow green yellow yellow
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    L3MBTL1 yellow yellow yellow gray yellow
    ZNF785 yellow yellow yellow yellow yellow
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    MCF2L-AS1 yellow yellow yellow red yellow
    TDRKH yellow yellow yellow yellow yellow
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    KCNK5 yellow yellow green red yellow
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    MYRIP yellow yellow green red yellow
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    DBI yellow gray yellow red yellow
    FGFR4 yellow yellow yellow red yellow
    AGMAT yellow yellow yellow red yellow
    RAB11FIP4 yellow gray yellow red yellow
    GNL3L yellow yellow yellow yellow yellow
    FHDC1 yellow yellow green red yellow
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    EPHB2 yellow yellow green red yellow
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    FERMT1 yellow yellow yellow red yellow
    ATP11A yellow gray yellow yellow yellow
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    RFXAP yellow yellow yellow yellow yellow
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    PHOSPHO2 yellow yellow yellow red yellow
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    BRCC3 yellow yellow yellow red yellow
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    ZDHHC23 yellow yellow green red yellow
    GPSM2 yellow yellow yellow red yellow
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    NFE2L3 yellow yellow yellow red yellow
    SRPK1 yellow gray yellow red yellow
    MYB yellow red green red yellow
    STRBP yellow yellow yellow red yellow
    CLDN15 yellow yellow yellow yellow yellow
    ERP27 yellow yellow yellow red yellow
    APCDD1 yellow yellow yellow yellow yellow
    CAB39L yellow yellow yellow gray yellow
    SYNE4 yellow yellow gray yellow yellow
    IRF2BP2 yellow gray yellow yellow yellow
    PTPRO yellow yellow yellow red yellow
    LRRC2 yellow yellow yellow yellow yellow
    BCL11A yellow yellow yellow red yellow
    FOXO3 yellow yellow yellow gray yellow
    SESN1 yellow yellow yellow yellow yellow
    DGAT2 yellow yellow yellow yellow yellow
    COL9A3 yellow yellow yellow gray yellow
    USP7 yellow yellow yellow yellow yellow
    C6orf123 yellow yellow yellow yellow yellow
    LAPTM4B yellow yellow yellow yellow yellow
    ZFAS1 yellow yellow yellow yellow yellow
    FER1L4 yellow yellow yellow yellow yellow
    MAP1LC3A yellow yellow yellow gray yellow
    CTSA yellow yellow yellow yellow yellow
    SDC4 yellow yellow yellow yellow yellow
    GPR56 yellow yellow yellow yellow yellow
    CACNA1D yellow yellow yellow yellow yellow
    EPDR1 yellow yellow yellow yellow yellow
    PROX1 yellow yellow yellow yellow yellow
    DACH1 yellow yellow yellow red yellow
    DUSP18 yellow yellow yellow red yellow
    PTCH1 yellow yellow yellow red yellow
    RLN2 yellow yellow yellow yellow yellow
    BCL2L1 yellow yellow yellow gray yellow
    PRDX5 yellow yellow green red yellow
    SHANK2 yellow yellow yellow yellow yellow
    KHDRBS3 yellow yellow yellow yellow yellow
    GYG2 yellow yellow yellow yellow yellow
    IL22RA1 yellow yellow yellow yellow yellow
    PAH yellow yellow yellow yellow yellow
    DUSP16 yellow yellow green red yellow
    NONO yellow gray yellow yellow yellow
    NCOA3 yellow yellow yellow yellow yellow
    ETV4 yellow yellow yellow yellow yellow
    SPIRE2 yellow yellow yellow yellow yellow
    ANO9 yellow yellow yellow yellow yellow
    ENGASE yellow yellow yellow yellow yellow
    GAS2 yellow yellow yellow yellow yellow
    PIPOX yellow yellow yellow yellow yellow
    CYP2B6 yellow yellow green red yellow
    ELMO2 yellow yellow yellow yellow yellow
    NKD1 yellow yellow yellow yellow yellow
    DPEP1 yellow yellow yellow red yellow
    ZNRF3 yellow yellow yellow red yellow
    C7orf13 yellow yellow yellow yellow yellow
    SLC7A6 yellow yellow yellow yellow yellow
    TLE2 yellow yellow yellow yellow yellow
    EMILIN3 yellow yellow yellow yellow yellow
    EPB41L1 yellow yellow yellow yellow yellow
    MAP7D2 yellow yellow yellow yellow yellow
    REPIN1 yellow yellow yellow red yellow
    PM20D2 yellow yellow yellow yellow yellow
    CRCP yellow gray yellow yellow yellow
    GGH yellow yellow yellow red yellow
    ABAT yellow yellow yellow yellow yellow
    C11orf95 yellow yellow yellow yellow yellow
    ZNF217 yellow yellow yellow yellow yellow
    CHN2 yellow yellow yellow yellow yellow
    GSE1 yellow yellow yellow yellow yellow
    RBP2 yellow yellow yellow yellow yellow
    SHROOM2 yellow yellow yellow yellow yellow
    AKAP1 yellow yellow yellow yellow yellow
    STOX1 yellow yellow yellow yellow yellow
    SLC19A3 yellow yellow yellow gray yellow
    ACSL6 yellow yellow yellow yellow yellow
    CASK yellow gray yellow yellow yellow
    CTPS2 yellow yellow yellow yellow yellow
    HSPH1 yellow yellow yellow yellow yellow
    GTF2F2 yellow gray yellow yellow yellow
    NDFIP2 yellow yellow yellow yellow yellow
    TMTC4 yellow yellow yellow yellow yellow
    UCHL3 yellow yellow yellow gray yellow
    SPATA13 yellow yellow yellow yellow yellow
    NEK3 yellow yellow yellow yellow yellow
    PROSER1 yellow yellow yellow yellow yellow
    WDR35 yellow yellow yellow yellow yellow
    ZNF514 yellow yellow yellow yellow yellow
    CBFA2T2 yellow yellow yellow yellow yellow
    ZMYND8 yellow yellow yellow yellow yellow
    CHD6 yello yellow yello yellow yello
    PABPC1L yello yellow yello yellow yello
    RAB22A yello yellow yello yellow yello
    LINC00657 yello yellow yello yellow yello
    RBM39 yello yellow yello yellow yello
    ARFGEF2 yello yellow yello yellow yello
    PCMTD2 yello yellow yello yellow yello
    STX16 yello gray yello yellow yello
    EREG yello yellow yello yellow yello
    GGT7 yello yellow yello yellow yello
    PARD6B yello yellow yello yellow yello
    TOP1 yello gray yello yellow yello
    YAE1D1 yello yellow yello yellow yello
    MYC yello yellow yello yellow yello
    TNNC2 yello yellow yello yellow yello
    CEL yello yellow yello yellow yello
    CELP yello yellow yello yellow yello
    ZDHHC9 yello yellow yello yellow yello
    HUNK yello yellow yello red yello
    AXIN2 yello yellow yello red yello
    ASCL2 yello yellow yello red yello
    RNF43 yello yellow yello red yello
    QPRT yello yellow yello yellow yello
    TSPAN6 yello yellow gree red yello
    VAV3 yello yellow gree red yello
    NEU1 yello yellow yello yellow yello
    C8orf33 yello yellow yello yellow yello
    PLA2G12B yello yellow yello yellow yello
    GTF2IRD1 yello yellow yello yellow yello
    POFUT1 yello yellow yello yellow yello
    KRT23 yello yellow yello yellow yello
    ARID3A yello yellow yello yellow yello
    CABLES2 yello yellow yello yellow yello
    SERINC3 yello yellow yello yellow yello
    GNG4 yello yellow yello yellow yello
    GPR143 yello yellow yello yellow yello
    SPATA2 yello yellow yello yellow yello
    MOCS3 yello gray yello yellow yello
    NDRG3 yello gray yello yellow yello
    TTPAL yello yellow yello yellow yello
    ATP9A yello yellow yello yellow yello
    CHMP4B yello yellow yello yellow yello
    COMMD7 yello yellow yello yellow yello
    EIF2S2 yello yellow yello yellow yello
    TCFL5 yello yellow yello yellow yello
    DSN1 yello gray yello gray yello
    SLMO2 yello yellow yello yellow yello
    CSE1L yellow yellow yellow yellow yellow
    DPM1 yellow yellow yellow yellow yellow
    PFDN4 yellow yellow yellow yellow yellow
    ACOT8 yellow yellow yellow yellow yellow
    DHX35 yellow yellow yellow yellow yellow
    PXMP4 yellow yellow yellow yellow yellow
    AHCY yellow yellow yellow yellow yellow
    MRGBP yellow gray yellow gray yellow
    AURKA yellow gray yellow gray yellow
    TPX2 yellow gray yellow gray yellow
    UBE2C yellow gray yellow gray yellow
    SLC5A6 yellow yellow yellow yellow yellow
    FITM2 yellow yellow yellow yellow yellow
    TM9SF4 yellow yellow yellow yellow yellow
    UCKL1 yellow yellow yellow yellow yellow
    DNTTIP1 yellow yellow yellow yellow yellow
    RNF114 yellow yellow yellow yellow yellow
    GSS yellow yellow yellow yellow yellow
    SCAND1 yellow yellow yellow yellow yellow
    TP53RK yellow yellow yellow yellow yellow
    ADRM1 yellow yellow yellow yellow yellow
    TOMM34 yellow yellow yellow yellow yellow
    RPS21 yellow yellow yellow yellow yellow
    CPNE1 yellow yellow yellow yellow yellow
    ASXL1 yellow yellow yellow yellow yellow
    ROMO1 yellow yellow yellow yellow yellow
    RAE1 yellow yellow yellow yellow yellow
    VAPB yellow yellow yellow yellow yellow
    ERGIC3 yellow yellow yellow yellow yellow
    PLAGL2 yellow yellow yellow yellow yellow
    DYNLRB1 yellow yellow yellow yellow yellow
    TTI1 yellow yellow yellow yellow yellow
    PRPF6 yellow yellow yellow yellow yellow
    YTHDF1 yellow yellow yellow yellow yellow
    DDX27 yellow yellow yellow yellow yellow
    EIF6 yellow yellow yellow yellow yellow
    PIGU yellow yellow yellow yellow yellow
    NELFCD yellow yellow yellow yellow yellow
    CTNNBL1 yellow yellow yellow yellow yellow
    PSMA7 yellow yellow yellow yellow yellow
    KIF3B yellow yellow yellow yellow yellow
    FAM217B yellow yellow yellow yellow yellow
    PPP1R3D yellow yellow yellow yellow yellow
    DIDO1 yellow yellow yellow yellow yellow
    STK4 yellow yellow yellow yellow yellow
    YWHAB yellow yellow yellow yellow yellow
    LPAR3 red gray gray gray red
    PF4 red gray gray red red
    SDC1 red gray green red red
    TMEM2 red gray red red red
    IGFBP2 red gray green gray red
    FOXA1 red gray gray gray red
    RRN3P1 red gray gray red red
    CEACAM8 red gray green red red
    GIF red magenta green red red
    C1orf116 red magenta green red red
    RELL1 red gray gray red red
    UBXN10 red gray gray red red
    ZFP3 red gray green red red
    SLC35G1 red gray gray gray red
    HES1 red gray green gray red
    FAIM2 red gray gray gray red
    KCNN4 red gray green red red
    GAL3ST1 red red green red red
    METTL7B red red green red red
    SLC9A3R1 red gray gray red red
    COBL red gray gray gray red
    LTK red gray gray gray red
    ENTPD2 red gray green gray red
    MAP3K13 red gray green gray red
    TM4SF20 red gray gray red red
    CCL24 red gray gray red red
    CHST4 red gray gray gray red
    EGF red red gray gray red
    DEFA5 red greenyellow green red red
    DEFA6 red greenyellow green red red
    LYPD6B red gray gray gray red
    DNAJC12 red gray gray gray red
    PCSK1 red magenta gray gray red
    NTN4 red greenyellow gray gray red
    SMAD9 red gray green gray red
    GPR128 red gray gray gray red
    PCCA red magenta green red red
    COL4A5 red greenyellow green gray red
    CASZ1 red gray red gray red
    OTC red gray green gray red
    REG3A red magenta red gray red
    REG1P red magenta red gray red
    REG1A red magenta red gray red
    REG1B red magenta red gray red
    CAPN12 red gray red red red
    C21orf33 red gray gray red red
    LONRF3 red magenta red gray red
    PRKAG2-AS1 red gray gray gray red
    SOSTDC1 red gray gray red red
    RNF183 red magenta red gray red
    ZC3H12D red gray gray red red
    HR red gray gray red red
    TMED6 red red gray red red
    PCDH20 red gray green gray red
    AKR1C3 red gray green red red
    TSPAN7 red greenyellow green gray red
    CYCS red gray green gray red
    C4BPA red red red red red
    TM4SF5 red red green red red
    TLE1 red magenta red gray red
    NDNF red red green gray red
    ACOT13 red red green red red
    ACAA2 red red gray red red
    MKNK2 red gray gray red red
    C1orf226 red magenta gray red red
    NEO1 red red green red red
    MTMR11 red red green red red
    PVRL3 red red green red red
    DEFB1 red gray gray gray red
    SLC16A5 red gray green red red
    ARHGAP27 red gray gray red red
    ERBB2 red gray green red red
    RAPGEFL1 red red green red red
    PROM1 red gray gray red red
    DHRS1 red gray red gray red
    NOXO1 red red green gray red
    C2orf82 red red green red red
    SMAGP red red green red red
    TMEM141 red red green gray red
    ABHD14B red gray green red red
    BAIAP2L2 red gray green red red
    STARD10 red gray green red red
    ASL red red green red red
    CLN3 red gray green red red
    FAAH red gray green red red
    NOS2 red gray gray gray red
    TRIM15 red gray gray gray red
    KCNE3 red gray green red red
    SCIN red magenta green red red
    GSTA1 red gray green gray red
    COL17A1 red gray green red red
    NPY6R red gray gray gray red
    NQO1 red red green red red
    CAPN8 red red green gray red
    MXD1 red gray green gray red
    TRIM31 red red green red red
    ALDH6A1 red gray red red red
    CYP2C18 red gray red gray red
    CYP2C9 red gray red gray red
    WFDC2 red red green gray red
    ANXA13 red magenta green red red
    C1orf115 red red gray red red
    PRSS16 red gray red gray red
    GDA red magenta red gray red
    ADORA2B red gray red gray red
    APOBEC1 red red green red red
    MAP2K6 red gray green red red
    EMP2 red red green red red
    TRHDE red red green red red
    VWA5A red red green gray red
    PPARGC1A red gray green red red
    UGT2A3 red red green red red
    CNTN3 red greenyellow green gray red
    HAPLN1 red gray gray gray red
    BMP5 red greenyellow gray gray red
    FAM150B red greenyellow green gray red
    ITGA8 red greenyellow gray gray red
    ADAMDEC1 red greenyellow gray gray red
    DNASE1L3 red greenyellow gray gray red
    METTL7A red gray green gray red
    SEPP1 red greenyellow green gray red
    LPHN3 red greenyellow green red red
    BBIP1 red greenyellow green red red
    PRKACB red greenyellow green gray red
    PCSK6 red gray red red red
    SLPI red magenta red gray red
    L1TD1 red magenta red gray red
    GNA14 red magenta red gray red
    NEDD9 red magenta red gray red
    TPK1 red gray gray gray red
    GAREM red magenta gray gray red
    CNGA1 red red green red red
    ADH6 red red green red red
    CMBL red magenta red red red
    ATP1B1 red gray red gray red
    NPDC1 red magenta red gray red
    COL9A2 red red red gray red
    TMEM45B red red gray red red
    BLNK red magenta red gray red
    TMEM92 red magenta red gray red
    BACE2 red magenta red red red
    RASAL1 red magenta red gray red
    LINC00668 red red green gray red
    AXDND1 red red green red red
    COL4A6 red greenyellow green gray red
    SLC6A14 red magenta red gray red
    IRF6 red gray green red red
    ASS1 red magenta gray gray red
    GSDMB red gray gray gray red
    SGPP2 red gray gray gray red
    RORC red red red red red
    3-Mar red magenta red gray red
    CLDN23 red greenyellow green red red
    CDHR2 red gray green red red
    MALL red red green gray red
    LRG1 red magenta red gray red
    PTPRF red gray green red red
    SERINC2 red red green red red
    WNT4 red red gray red red
    S100P red magenta red gray red
    OVOL2 red gray green red red
    TMEM37 red greenyellow green gray red
    TUBAL3 red red green red red
    EPHX2 red red red red red
    GBA3 red gray green gray red
    NR1H4 red gray green gray red
    TMEM254 red gray green gray red
    HOXB13 red gray red red red
    C1orf21 red magenta red gray red
    ALDOB red red green gray red
    LGALS2 red gray green gray red
    PDCD6IP red gray gray red red
    ZG16B red red red gray red
    TMPRSS4 red red green red red
    SLC5A1 red red green red red
    SLC44A3 red red green red red
    PLEKHA6 red red green gray red
    STAP2 red red green red red
    MAOA red red green red red
    ANKS4B red red green red red
    NRARP red red green red red
    BDH1 red red green red red
    HADH red red green red red
    PPP1R1B red red green red red
    FUT3 red gray green red red
    FUT6 red red green red red
    TMC4 red red green red red
    BCL2L14 red red green red red
    ATP2C2 red red green red red
    TTC39A red red green red red
    FZD5 red red green red red
    CORO2A red red green red red
    CALML4 red red green red red
    PIP5K1B red red green red red
    CLRN3 red red green red red
    MUC13 red red red red red
    PRR15L red red green red red
    HDHD3 red red green red red
    USH1C red red green red red
    DMBT1 red magenta red red red
    BCL2L15 red red green red red
    LCN2 red red red gray red
    PDZK1IP1 red red red red red
    HGD red red red red red
    HMGN2P46 red magenta green red red
    MMP28 red magenta gray red red
    ALDH1L1 red gray red gray red
    DQX1 red red gray red red
    TMEM171 red gray red gray red
    FUT2 red red red red red
    ACSM3 red red green red red
    NDRG2 red red green gray red
    GOLM1 red red red red red
    SYTL5 red red green red red
    TRPM4 red red green red red
    PI3 red magenta red gray red
    CRYM red red green red red
    CLMN red red green red red
    PRSS12 red magenta gray red red
    C1orf210 red gray gray red red
    ABCC3 red red gray red red
    PIGR red red red gray red
    SLC28A2 red red green gray red
    BMP2 red magenta red gray red
    TRPA1 red greenyellow green red red
    NUDT16 red magenta red red red
    SCNN1A red red red red red
    TMEM246 red magenta red gray red
    SLITRK6 red magenta red gray red
    CATSPERB red magenta red gray red
    AMN red magenta gray gray red
    FRMD3 red magenta gray gray red
    TSPAN3 red gray red red red
    CHP1 red gray red gray red
    HSD17B2 red red gray gray red
    GCNT3 red magenta red gray red
    LIPH red magenta gray gray red
    PPP1R36 red red red red red
    GALNT12 red magenta red red red
    KIAA1324 red magenta red red red
    C9orf152 red red green red red
    FOXA3 red red red red red
    MUC5B red magenta red gray red
    TCEA3 red magenta green red red
    RETNLB red red green red red
    SLC9A2 red red green red red
    C2orf72 red magenta red gray red
    PTGER4 red red red gray red
    PDXDC1 red gray red red red
    PLD1 red red red gray red
    SHROOM3 red magenta red red red
    TSPAN13 red magenta red gray red
    IQGAP2 red magenta red gray red
    DSC2 red gray red red red
    CAMK2D red gray gray gray red
    ATP8A1 red magenta red gray red
    SLC2A13 red magenta red red red
    PAPSS2 red magenta red red red
    LGR4 red magenta red red red
    TNFRSF11A red magenta red gray red
    STYK1 red magenta red gray red
    CCDC68 red magenta gray gray red
    CASP7 red magenta red gray red
    LIMA1 red red red gray red
    ABHD3 red gray red gray red
    GSKIP red magenta red gray red
    TC2N red magenta gray gray red
    SMIM14 red magenta red gray red
    LAMA1 red magenta gray red red
    ASRGL1 red magenta red gray red
    TFF3 red red red red red
    GNE red magenta red gray red
    RNASE4 red magenta red gray red
    TFF1 red magenta red gray red
    PTGER2 red magenta red gray red
    RHBDL2 red magenta red red red
    MB red magenta red gray red
    RAP1GAP red magenta red gray red
    AGR2 red magenta red gray red
    AGR3 red magenta red gray red
    MRAP2 red magenta red red red
    ANG red magenta red gray red
    ZBTB7C red magenta red gray red
    ST3GAL4 red magenta red gray red
    KLK1 red magenta green red red
    CHST5 red magenta red red red
    FFAR4 red magenta red gray red
    KLF4 red gray red gray red
    ATP2A3 red gray red red red
    TMEM61 red magenta red gray red
    ATOH1 red magenta red red red
    LINC00261 red magenta red gray red
    BCAS1 red magenta red red red
    SPDEF red magenta red gray red
    CAPN9 red magenta red gray red
    ST6GALNAC1 red magenta red red red
    ITLN1 red magenta red red red
    REG4 red magenta red gray red
    HEPACAM2 red magenta red red red
    B3GNT6 red magenta red gray red
    SPINK4 red magenta red gray red
    FCGBP red magenta red gray red
    MUC2 red magenta red gray red
    CREB3L1 red magenta red gray red
    RAB26 red magenta red gray red
    SIDT1 red magenta red gray red
    MLPH red magenta red gray red
    RAB27B red magenta gray gray red
    GDPD3 red gray green red red
    CES2 red red green red red
    NR5A2 red red green red red
    PARM1 red gray red red red
    DHRS11 red gray green red red
    CWH43 red red green red red
    GNA11 red gray green gray red
    TST red red gray red red
    HRCT1 red red green red red
    PKIB red greenyellow green gray red
    SMPDL3A red gray red gray red
    SMPD3 red red green red red
    FMO5 red red green red red
    INSL5 red gray gray gray red
    DENND2A red gray green red red
    FAM162A red red green red red
    SRI red gray green red red
    SLC17A4 red red green red red
    PDE9A red red green red red
    MGLL red greenyellow green red red
    ACVRL1 red greenyellow green red red
    RNF186 red red green red red
    DUOX2 red red green re red
    DUOXA2 red red green re red
    FXYD3 red gray red re red
    LGALS3 red gray green re red
    GGT6 red red green re red
    MYO1A red red green re red
    CASP5 red red red re red
    UGT2B15 red red green re red
    UGT2B17 red greenyellow green re red
    FAM132A red red green re red
    EDN3 red greenyellow green re red
    TTC22 red red green re red
    PTPRH red red red re red
    TMEM54 red red red re red
    CDC42EP5 red red red re red
    ETHE1 red red red re red
    LRRC66 red red green re red
    CA12 red magenta red re red
    CDHR5 red red green re red
    BTNL8 red red gray re red
    CHP2 red red green re red
    HHLA2 red red green re red
    SLC51B red red green re red
    PLCE1 red red green re red
    HSD11B2 red red green re red
    VIPR1 red red green re red
    FAM3D red red green re red
    CAPN5 red red green re red
    C4orf19 red red red re red
    SLC44A4 red red green re red
    LINC00675 red red green re red
    GPA33 red red green re red
    LGALS4 red red green re red
    PADI2 red greenyellow green re red
    MOGAT2 red red green re red
    CEACAM7 red red green re red
    NXPE1 red red green re red
    NXPE4 red red green re red
    ENTPD5 red red green re red
    SULT1B1 red red green re red
    XDH red red red re red
    CES3 red red red re red
    AHCYL2 red gray red re red
    AKR1B10 red red green re red
    SIAE red gray red re red
    ATP8B1 red gray red re red
    RBM47 red gray red re red
    SCGB2A1 red magenta red gray red
    CHGA red greenyellow green gray red
    SCARA5 red greenyellow green gray red
    MFSD4 red red green red red
    PLAC8 red magenta red gray red
    AQP8 red red green red red
    B3GNT7 red gray green gray red
    GCG red greenyellow green gray red
    ADH1C red red green red red
    ABCC13 red red green red red
    DHRS9 red gray green gray red
    ADTRP red red green gray red
    ITM2C red gray red red red
    BEST2 red red green red red
    MUC4 red magenta red gray red
    TSPAN1 red red red red red
    NR3C2 red magenta red red red
    CLCA1 red red red red red
    CCL28 red red red red red
    VSIG2 red red red red red
    SPINK5 red red green gray red
    C2orf88 red greenyellow green red red
    SI red red green gray red
    SCNN1B red gray green red red
    CLDN8 red gray green gray red
    CD177 red gray green gray red
    GUCA2B red red green gray red
    CLCA4 red red green red red
    MS4A12 red red green red red
    CA1 red red green gray red
    CA4 red red green gray red
    ZG16 red red green red red
    CA2 red gray red gray red
    SLC4A4 red magenta red gray red
    MGST1 red gray gray gray red
    GATA6 red gray gray red red
    PPARGC1B red gray gray red red
    KBTBD11 red red gray red red
    PLEKHH1 red red gray red red
    SH3RF2 red red red red red
    SLC39A8 red magenta red red red
    UQCRC2 red gray red red red
    DNAJC22 red red green gray red
    NEDD4L red gray red red red
    C3orf52 red magenta red gray red
    ARHGAP32 red gray red red red
    ELL3 red magenta gray gray red
    LRRC16A red gray gray gray red
    EHHADH red gray green red red
    TRIM36 red gray red red red
    MYO5C red gray gray gray red
    TTC19 red gray red gray red
    HK2 red gray red gray red
    BCL10 red gray red red red
    F2RL1 red red red gray red
    ELOVL6 red gray gray gray red
    FRK red gray gray gray red
    MCTP2 red gray red gray red
    SLC27A2 red gray red gray red
    AFG3L2 red magenta gray gray red
    PKP2 red gray red gray red
    UGT8 red gray red gray red
    ALDH1A2 black black black black
    SBSPON turquoise turquoise gray turquoise
    MSX2 turquoise turquoise gray gray
    TBX3 brown green gray gray
    KREMEN1 brown green gray gray
    DKK4 turquoise gray gray turquoise
    SP5 brown gray gray gray
    AVPR1A black black gray black
    FGB turquoise gray gray gray
    CD99P1 turquoise gray gray turquoise
    ONECUT2 turquoise gray gray gray
    AIM1L turquoise gray gray turquoise
    IQCE black gray gray gray
    NOL3 turquoise gray gray turquoise
    SPNS2 black black black gray
    DUSP27 turquoise gray gray turquoise
    ZNF718 black gray black black
    FOLR1 turquoise turquoise gray gray
    SOX1 turquoise gray gray turquoise
    LINC00476 turquoise gray turquoise gray
    ADH4 turquoise gray gray turquoise
    PTPRN2 turquoise gray turquoise gray
    SOX6 turquoise gray turquoise turquoise
    EML6 turquoise turquoise gray gray
    APH1A black gray gray gray
    REEP6 black gray gray gray
    AGFG2 brown green gray gray
    AMFR black gray gray gray
    HMBOX1 turquoise gray gray turquoise
    GRIN2D brown gray gray gray
    KDELR1 turquoise gray gray turquoise
    LPHN1 turquoise gray gray turquoise
    NSMF brown gray gray brown
    SH3GLB2 black gray black gray
    ARHGDIA turquoise gray gray turquoise
    MAZ brown green gray brown
    GNB2 black gray gray gray
    YKT6 turquoise gray gray gray
    OGDH turquoise gray gray gray
    URGCP turquoise gray gray gray
    GABRB1 turquoise turquoise turquoise turquoise
    NFIA turquoise gray gray gray
    ECHDC2 turquoise gray gray turquoise
    RHOU turquoise gray gray turquoise
    CPA6 turquoise turquoise gray gray
    MLXIP turquoise gray gray turquoise
    RERE turquoise gray turquoise turquoise
    EP400 green gray yellow yellow
    SPEN turquoise gray gray turquoise
    SRRM2 turquoise gray gray turquoise
    ARMCX4 turquoise turquoise gray gray
    PON3 turquoise gray turquoise gray
    CLGN turquoise turquoise gray turquoise
    SHC3 turquoise turquoise gray turquoise
    CA9 black gray gray gray
    WISP3 turquoise gray gray turquoise
    NMU turquoise gray turquoise gray
    MALAT1 turquoise gray gray turquoise
    DAPP1 black black black black
    GTSE1 brown brown gray brown
    AKR1C4 turquoise gray gray gray
    MIRLET7DHG turquoise turquoise gray turquoise
    C12orf56 turquoise gray turquoise gray
    PEX6 turquoise gray turquoise gray
    MAGEA11 turquoise gray gray turquoise
    NOS3 turquoise gray turquoise turquoise
    THSD4 turquoise gray gray turquoise
    MCOLN2 black black black gray
    SPAG16 turquoise turquoise gray turquoise
    PPP2R2C turquoise gray gray gray
    WFS1 turquoise gray turquoise gray
    TNFSF15 black gray gray gray
    AGA black gray gray gray
    ABCA12 black black gray gray
    WDR72 turquoise gray turquoise gray
    IL17A turquoise gray gray gray
    DPP10 turquoise gray turquoise turquoise
    MTTP turquoise gray turquoise gray
    MXI1 turquoise gray turquoise turquoise
    SLC38A11 turquoise gray gray turquoise
    DSC3 turquoise turquoise turquoise turquoise
    HOXB-AS3 turquoise turquoise turquoise turquoise
    HOXB9 yellow yellow green gray
    HOXB8 turquoise turquoise gray gray
    HOXB7 black gray black gray
    HOXB3 turquoise turquoise turquoise gray
    HOXB5 turquoise turquoise gray gray
    HOXB6 black black black gray
    TESC turquoise gray turquoise turquoise
    HOXA2 turquoise turquoise gray turquoise
    HOXA3 turquoise turquoise gray gray
    HOXA13 yellow gray yellow red
    HOXA11-AS turquoise gray gray gray
    HOXA10 turquoise turquoise gray gray
    HOXA11 turquoise turquoise gray turquoise
    HOXA5 turquoise turquoise turquoise turquoise
    HOXA7 turquoise turquoise gray turquoise
    KCNJ3 black gray black gray
    MUC17 black gray black gray
    PRKCA turquoise gray gray turquoise
    SLC38A5 black gray gray gray
    TIMP4 turquoise gray gray gray
    FAM118A turquoise gray gray turquoise
    GSTM4 black gray black black
    ERAP1 black black black gray
    SYNPR turquoise turquoise gray turquoise
    CHST13 turquoise gray gray gray
    CYP4V2 black black black gray
    ZNF334 turquoise turquoise turquoise turquoise
    WIPI1 turquoise gray gray gray
    IL33 turquoise turquoise turquoise turquoise
    NTS turquoise turquoise turquoise turquoise
    TNIK turquoise gray gray gray
    SPAG4 turquoise gray turquoise turquoise
    CTBP1 turquoise gray gray turquoise
    CLDN10 turquoise gray turquoise turquoise
    ORM1 turquoise gray turquoise gray
    GPR37 turquoise gray gray turquoise
    CTTN black black black gray
    ITGB8 turquoise turquoise gray turquoise
    PTGR1 black gray gray gray
    SCD5 turquoise turquoise gray turquoise
    TRIM4 turquoise gray turquoise turquoise
    NUCKS1 turquoise gray gray gray
    ZC3HAV1 turquoise gray gray gray
    EGFR turquoise gray gray gray
    SRGAP1 turquoise gray gray gray
    SALL1 turquoise gray gray gray
    GRB14 black gray gray gray
    LGSN turquoise gray turquoise turquoise
    GLDN black gray black gray
    GPR27 black gray gray gray
    ATHL1 turquoise turquoise gray turquoise
    ALDH1B1 turquoise gray gray gray
    UBE4B turquoise gray turquoise turquoise
    C6orf141 black gray gray gray
    CACNB2 turquoise gray gray turquoise
    PRUNE2 turquoise turquoise gray turquoise
    KCNQ1OT1 turquoise turquoise turquoise turquoise
    PID1 turquoise gray gray turquoise
    RAB32 turquoise gray gray turquoise
    MTSS1 turquoise turquoise turquoise turquoise
    IER3 turquoise gray turquoise turquoise
    LRRN1 turquoise gray turquoise turquoise
    CELSR1 turquoise turquoise gray turquoise
    TMEM178B turquoise gray gray gray
    MAP2K7 black gray black gray
    KCNJ2 black black black black
    RNF39 turquoise gray turquoise turquoise
    LGR6 turquoise turquoise gray turquoise
    OAS1 black gray black black
    JAG2 turquoise turquoise turquoise gray
    SULT1E1 turquoise gray gray gray
    TP53 black gray black black
    KANSL1-AS1 black gray gray gray
    OLFM1 turquoise turquoise turquoise turquoise
    WNT11 turquoise gray turquoise gray
    LRRC41 turquoise gray gray turquoise
    SHISA6 turquoise gray turquoise turquoise
    C15orf57 black gray black gray
    GPR64 turquoise turquoise turquoise turquoise
    NDRG1 turquoise gray gray turquoise
    SLC6A8 black gray gray gray
    PYCARD black gray gray gray
    C2orf68 turquoise gray gray gray
    IFITM1 black gray black black
    NRCAM turquoise gray gray turquoise
    IL13RA2 turquoise turquoise turquoise turquoise
    MMP10 black black black black
    RPS23 turquoise gray gray turquoise
    MFI2 turquoise turquoise gray turquoise
    SLC51A black gray gray gray
    ZBED1 turquoise gray gray turquoise
    H2AFY2 turquoise gray turquoise turquoise
    SLCO1B3 black black gray gray
    FGF20 turquoise gray turquoise turquoise
    PRR9 turquoise gray gray turquoise
    KLHL13 turquoise gray turquoise turquoise
    SEZ6L2 turquoise gray gray turquoise
    GPM6A turquoise turquoise gray turquoise
    COL4A3 turquoise gray turquoise turquoise
    IRX2 turquoise gray gray gray
    ZDHHC2 turquoise gray gray gray
    FAM149A black black black gray
    TNFRSF21 black gray black gray
    TAPBPL black black black black
    HOXD13 turquoise gray turquoise turquoise
    CHURC1 black gray gray gray
    CCR6 black black gray black
    ARID1B turquoise gray turquoise turquoise
    ZC3H12C black black black black
    TMEM159 black gray black gray
    SH3KBP1 black black black gray
    CLIC5 black black black gray
    GMPR black black black black
    C11orf70 turquoise turquoise gray turquoise
    HIST1H2BC black black black black
    HIST1H1C black black black black
    HIST1H2BH black black gray gray
    HIST1H2BK black gray gray gray
    HIST1H2AC black gray gray gray
    HIST1H2BD black gray gray gray
    EMC3 black gray gray black
    MIDN turquoise gray turquoise turquoise
    TMPRSS3 black black black black
    TRIM29 turquoise turquoise turquoise turquoise
    PXN turquoise gray gray turquoise
    GJB3 black gray gray gray
    EPHA2 black gray black gray
    SFN black gray black gray
    VASP turquoise gray gray gray
    GPRC5A black gray gray gray
    S100A6 black gray black gray
    C19orf33 black gray gray gray
    CLTB black gray gray gray
    MINK1 black black black black
    GABRP black black black gray
    SLC28A3 black magenta black gray
    SYT13 black magenta black black
    RIMS3 black magenta gray gray
    DNAJA4 black gray black gray
    PPP1R9A green green gray gray
    MIPOL1 black black gray gray
    KANSL1L turquoise gray turquoise turquoise
    ZNF204P black magenta black black
    DUSP6 black black gray gray
    CPS1 black magenta black gray
    BTNL9 black magenta black black
    ANKRD37 black black black black
    MIR210HG black black black gray
    RPH3AL red magenta red gray
    VPS53 black magenta black gray
    RAP1GAP2 black magenta black gray
    ECI2 black black gray black
    AK1 black black black gray
    TSPAN15 black gray gray black
    SLC50A1 black gray gray gray
    CHCHD10 red gray gray gray
    GOT1 brown brown gray brown
    TSTA3 brown gray gray brown
    DEGS2 red magenta red gray
    IMPA2 red magenta red red
    GMDS red gray red gray
    ACPP brown gray gray brown
    RSPH1 brown gray gray brown
    FGFBP1 red gray red gray
    GLRX black black gray black
    CLDN18 black black black black
    SLC16A14 black black black black
    NXF3 black magenta gray gray
    SLC25A37 black gray black gray
    ME1 black magenta gray gray
    SSTR1 brown gray gray gray
    PITPNM3 red magenta red gray
    GALNT5 black magenta gray gray
    BAG1 black gray gray gray
    SLAIN1 black magenta black black
    ARSJ black magenta black black
    SLC36A4 black black black black
    GP2 black magenta black gray
    SERPINA1 black magenta gray black
    CKAP4 turquoise gray gray gray
    RASD1 turquoise gray gray turquoise
    SLC18A1 red magenta red gray
    FAM174B turquoise gray gray gray
    CA8 red magenta red gray
    AQP3 black magenta gray gray
    TOX black magenta gray black
    ISL1 black black black black
    ARX black magenta black black
    SEMG1 black magenta black gray
    ANXA10 black black black gray
    PLA2G2A black magenta black black
    AGPAT9 black magenta gray black
    KIAA1211 black black black gray
    HS3ST1 black magenta black gray
    VNN1 black black black black
    F3 black magenta black gray
    MBOAT1 black gray gray black
    SLC1A1 black magenta black black
    PLA2G4A black magenta black black
    MUC1 black magenta gray gray
    TCN1 black magenta gray gray
    KCNK6 black magenta black black
    KLK11 black black gray gray
    MUC5AC black magenta black gray
    S100A14 red magenta red gray
    SYTL4 black magenta gray gray
    SERPINB5 black magenta black gray
    KCNK1 black magenta gray gray
    C4BPB red magenta red gray
    CD55 black magenta gray gray
    SRD5A3 black magenta gray gray
    RNF125 black magenta black gray
    SLC17A5 black magenta gray gray
    IL1R2 black magenta gray gray
    CTSE black magenta gray gray
    FAM46A black magenta black gray
    PLLP black magenta black gray
    MYRF black magenta black gray
    TFF2 black magenta black gray
    QSOX1 black gray gray gray
    KDELR3 black magenta gray gray
    SEC24D black magenta black black
    CRIP1 black magenta black gray
    TFAP2A black magenta black gray
    SYTL1 black magenta black gray
    SDR16C5 black magenta gray gray
    DUSP4 black magenta black gray
    S100A16 black magenta black gray
    INPP1 black magenta gray gray
    TRIM7 black magenta gray gray
    ASPHD2 black magenta black gray
    HPSE black magenta black gray
    EGLN3 black magenta gray gray
    SERPINB1 black magenta gray gray
    IFNGR1 black gray black black
    IL18 black magenta black gray
    IVNS1ABP black magenta black black
    RPS27L black magenta black black
    SPATA18 black black black black
    KITLG turquoise gray gray gray
    SEC22B black gray black black
    FRMD4B black magenta gray gray
    SNAP23 black gray gray gray
    MTUS1 black magenta black gray
    RNF145 black magenta gray gray
    STS black magenta gray gray
    ENOSF1 brown brown gray brown
    KIAA0895 brown gray gray brown
    DYX1C1 black black black black
    OXCT1 black magenta black black
    TEX9 black magenta black gray
    FBXO16 brown gray gray brown
    PPAPDC1B black magenta black black
    MOCOS brown gray gray brown
    ME2 black gray black gray
    ZNF232 black gray black gray
    NUDT6 black magenta black gray
    SPTLC2 black gray black gray
    ARF6 black gray gray gray
    FUT8 black gray black gray
    SMEK1 black gray black gray
    CYB5D1 brown brown gray brown
    GLOD4 brown green gray brown
    SMAD2 black gray black gray
    SMAD4 black black black black
    SS18 black gray black gray
    SLC18B1 black magenta black gray
    GPR126 black gray black gray
    MBP black black black gray
    ZCCHC2 black black black gray
    INO80C black gray black gray
    FECH black magenta black gray
    PIAS2 black gray gray gray
    HSPA4L brown brown gray brown
    RPL22L1 black gray black gray
    CAPN6 turquoise turquoise turquoise turquoise
    ZNF844 turquoise turquoise turquoise turquoise
    TMEM99 turquoise turquoise gray turquoise
    MYEOV black black black gray
    TMEM150C turquoise turquoise gray turquoise
    DPP4 black black black black
    CYP27A1 turquoise gray gray turquoise
    PRSS21 black black black black
    KIF1C turquoise gray gray gray
    SERPIND1 turquoise gray gray turquoise
    BEX5 black black black gray
    TKTL1 turquoise gray gray gray
    ALPK3 turquoise turquoise turquoise turquoise
    CFB black black black black
    SYT17 turquoise gray gray turquoise
    TPPP black magenta black gray
    EFNB2 turquoise gray turquoise gray
    EPHB1 turquoise turquoise turquoise turquoise
    MAEL turquoise gray turquoise turquoise
    ZNF862 turquoise turquoise turquoise gray
    PRRC2B turquoise gray gray gray
    CELF2 turquoise gray turquoise turquoise
    SLC39A14 black gray black gray
    MCOLN3 turquoise gray turquoise turquoise
    CLN8 black gray gray gray
    C8orf4 turquoise gray turquoise turquoise
    TBXAS1 black black gray gray
    SULT1C4 turquoise gray gray gray
    MME turquoise turquoise turquoise turquoise
    ZIC2 black magenta black gray
    APOA2 turquoise gray gray gray
    TPPP3 turquoise gray gray turquoise
    SERP2 turquoise gray turquoise turquoise
    ARHGEF9 turquoise gray gray turquoise
    CNKSR3 turquoise gray turquoise turquoise
    PTGDR black black black black
    TSHZ1 turquoise turquoise turquoise turquoise
    TCAM1P turquoise gray gray gray
    IRX3 black black black gray
    C2 black black black gray
    MVB12A black black black gray
    RRAS2 turquoise gray turquoise turquoise
    LGALS9 black black black black
    ASPHD1 black gray black gray
    GAL turquoise turquoise turquoise turquoise
    SLC4A11 black black black gray
    PTPN13 turquoise turquoise gray turquoise
    MAGEA12 turquoise gray gray turquoise
    TMEFF2 turquoise gray gray turquoise
    KLHL29 turquoise gray gray turquoise
    NOD2 turquoise turquoise turquoise turquoise
    ACOT4 black gray gray gray
    MYBL1 black black black gray
    ZNF43 turquoise turquoise gray turquoise
    DLL1 turquoise gray gray turquoise
    FZD10 turquoise turquoise turquoise turquoise
    WWOX turquoise turquoise gray gray
    PTPN1 turquoise gray gray turquoise
    LARP6 turquoise turquoise gray turquoise
    LDLRAD3 turquoise gray gray turquoise
    XIST turquoise gray turquoise gray
    HLTF turquoise turquoise turquoise turquoise
    DMKN black magenta black black
    TNNC1 turquoise turquoise turquoise turquoise
    IL2RG black black gray black
    TMEM154 black gray gray black
    TPGS1 black black gray black
    GPC3 black gray gray black
    PRKCQ black black black black
    HP1BP3 turquoise gray turquoise turquoise
    SYT1 turquoise gray gray turquoise
    KCNMB4 turquoise turquoise turquoise turquoise
    NFIB turquoise gray turquoise turquoise
    RTN3 turquoise gray gray turquoise
    TSPAN5 turquoise turquoise gray turquoise
    XCL1 black black black gray
    TNFSF11 turquoise gray gray turquoise
    RUFY2 black gray black black
    FOXD1 black black black gray
    FREM1 turquoise turquoise gray gray
    RUNDC3B turquoise turquoise turquoise turquoise
    ZNF185 turquoise turquoise turquoise gray
    KIAA0125 black black black black
    PPL turquoise gray turquoise turquoise
    LMF1 turquoise gray turquoise turquoise
    FLRT3 black black black black
    LUZP1 turquoise turquoise gray turquoise
    SLC2A1 turquoise turquoise gray turquoise
    ARPC4 black gray black gray
    ABHD2 turquoise gray turquoise turquoise
    HHLA3 black gray black black
    EDN1 turquoise gray gray turquoise
    SATB1 turquoise turquoise gray turquoise
    RAPGEF4 turquoise turquoise turquoise turquoise
    DDX43 turquoise gray gray gray
    PSTPIP2 turquoise gray gray turquoise
    LEMD1 turquoise turquoise gray turquoise
    PVRL2 turquoise gray gray gray
    FRMD5 black black gray gray
    GAD1 black magenta black gray
    GSTZ1 black gray black gray
    MPI black gray black black
    KPNA6 black gray gray gray
    MOV10 black gray black gray
    UAP1L1 black gray black black
    CDK2AP2 black gray black gray
    LPCAT1 black magenta black gray
    BSG black gray black gray
    MIB2 black gray black gray
    TNFSF9 black gray black gray
    CBR3 black magenta black black
    ACIN1 black gray black gray
    AKT1 black gray black gray
    CALR black gray black black
    PFKP black gray black gray
    P4HB black gray black gray
    PKM black black black gray
    CDC42EP1 black gray black gray
    PFN1 black gray black gray
    RNF19B black gray black gray
    GPATCH2 turquoise gray gray turquoise
    HORMAD1 turquoise gray gray turquoise
    DSG3 turquoise turquoise turquoise turquoise
    NPY1R black gray gray gray
    SIPA1L2 turquoise gray gray turquoise
    BRD2 turquoise gray gray gray
    IL27RA black gray black black
    IRF8 black black black black
    GALC turquoise turquoise turquoise turquoise
    TGFA black gray gray gray
    COCH turquoise gray gray turquoise
    IQGAP1 turquoise gray gray gray
    BAMBI turquoise turquoise turquoise turquoise
    NFYC black gray black gray
    CYP27B1 black black black black
    ZNF117 turquoise turquoise turquoise turquoise
    FAM76A turquoise gray turquoise turquoise
    NME5 turquoise turquoise turquoise turquoise
    CPLX1 turquoise turquoise gray turquoise
    INSM1 black magenta black black
    MGMT turquoise gray turquoise turquoise
    INSR turquoise gray gray turquoise
    ERAP2 black black black black
    CACHD1 turquoise turquoise turquoise turquoise
    CD44 black magenta gray black
    ZNF662 turquoise gray gray turquoise
    GNAS turquoise gray gray turquoise
    PTPRR black black black black
    HFE black gray black black
    PIWIL1 black magenta black gray
    CSRNP3 turquoise turquoise turquoise turquoise
    PKDCC turquoise turquoise turquoise turquoise
    GPR155 turquoise turquoise gray turquoise
    SKAP1 black gray black gray
    IGF1R turquoise gray gray turquoise
    FBXL16 black magenta black black
    SOX2 turquoise gray gray gray
    LAMP1 turquoise gray gray turquoise
    C10orf11 turquoise gray gray turquoise
    TNFRSF11B turquoise turquoise turquoise turquoise
    ROBO2 turquoise gray gray turquoise
    GSTT1 black black gray black
    SQSTM1 turquoise gray gray turquoise
    HPGD black black gray gray
    AFAP1L1 black gray gray gray
    MAGEA1 black black black black
    RBP4 turquoise turquoise turquoise turquoise
    S100A10 turquoise gray gray gray
    BMP4 turquoise gray gray turquoise
    CLN5 black gray gray gray
    PLEKHA2 turquoise gray gray turquoise
    TGFBI turquoise turquoise gray turquoise
    SPAG9 turquoise gray turquoise turquoise
    MSLN turquoise turquoise turquoise gray
    HBEGF turquoise gray gray turquoise
    IGF2BP3 black black black black
    PCP4 turquoise gray gray turquoise
    NHS turquoise turquoise turquoise turquoise
    TACSTD2 turquoise turquoise turquoise turquoise
    2-Mar black magenta gray black
    STXBP1 turquoise gray gray turquoise
    ZNF655 turquoise gray turquoise turquoise
    TAGAP black black gray gray
    ID3 turquoise gray gray turquoise
    FGF18 turquoise turquoise gray turquoise
    GJB6 turquoise gray gray gray
    STEAP2 turquoise gray gray gray
    JUND turquoise gray gray turquoise
    SLC14A1 turquoise turquoise turquoise turquoise
    NPTX2 turquoise turquoise turquoise turquoise
    IGFBP1 turquoise turquoise turquoise turquoise
    F2RL2 turquoise gray gray turquoise
    BTBD11 turquoise turquoise turquoise turquoise
    GOLGA8A turquoise gray turquoise turquoise
    DNM3 turquoise turquoise gray turquoise
    KIF26A turquoise gray turquoise turquoise
    BTG2 turquoise gray gray turquoise
    CARD16 black black black black
    CASP1 black black black black
    NFATC2 turquoise turquoise gray turquoise
    KIAA1324L turquoise gray turquoise turquoise
    SORBS2 turquoise turquoise turquoise turquoise
    KLHL3 turquoise gray gray turquoise
    GSTM3 turquoise turquoise turquoise turquoise
    ZNF518B turquoise gray gray turquoise
    RASSF3 turquoise gray turquoise turquoise
    APLP2 turquoise gray turquoise turquoise
    NLRP2 turquoise turquoise gray turquoise
    SLFN13 black black black black
    NUB1 black black black black
    GABRB3 turquoise gray gray turquoise
    TTC9 turquoise turquoise gray turquoise
    FAM132B turquoise gray gray turquoise
    EPHA4 turquoise gray gray gray
    ZNF697 turquoise turquoise gray turquoise
    LAMP2 black gray gray gray
    FGF19 turquoise gray turquoise turquoise
    TMEM65 turquoise turquoise turquoise turquoise
    ABCA17P black gray black gray
    ALDH1A1 turquoise gray gray turquoise
    TMCO3 black gray black gray
    TMEM64 black black black gray
    PCED1A turquoise turquoise gray turquoise
    TMEM71 turquoise gray turquoise turquoise
    TFAP2C black black black gray
    PSD3 turquoise turquoise turquoise turquoise
    ZNF83 turquoise turquoise turquoise turquoise
    GATM turquoise turquoise turquoise turquoise
    FGF9 turquoise turquoise gray turquoise
    GSTA4 turquoise gray turquoise turquoise
    HOTAIR black black black gray
    PDE4A turquoise gray turquoise turquoise
    WNT5B turquoise gray turquoise turquoise
    HOXA1 turquoise turquoise gray gray
    CST3 turquoise gray gray turquoise
    CHGB turquoise turquoise turquoise turquoise
    TM4SF4 turquoise gray gray turquoise
    CD163L1 black black black black
    IL17RD turquoise turquoise turquoise turquoise
    SKAP2 turquoise turquoise turquoise gray
    STEAP1 black black black black
    ECHDC3 turquoise gray turquoise turquoise
    PGM2L1 turquoise turquoise turquoise turquoise
    FKBP11 black black black black
    ALCAM turquoise gray gray turquoise
    ZNF347 turquoise turquoise turquoise turquoise
    DNALI1 turquoise gray turquoise turquoise
    DDX58 black black black black
    HCP5 black black black gray
    RPL39L turquoise gray turquoise turquoise
    FABP3 turquoise gray turquoise turquoise
    APOLD1 turquoise gray gray turquoise
    CDC42 black gray gray gray
    GBP3 black black black black
    FBP1 black black gray black
    EHD4 black gray gray gray
    KRT80 turquoise turquoise turquoise turquoise
    OBSCN turquoise turquoise gray turquoise
    ADRB1 black magenta black gray
    EMB black black gray gray
    GZMB black black black black
    FGFR2 turquoise gray gray turquoise
    GLCCI1 black black gray black
    OSR2 black magenta black black
    ENPP1 turquoise turquoise gray turquoise
    ADPGK black gray black black
    CLIC3 turquoise turquoise turquoise turquoise
    PYROXD2 turquoise gray gray turquoise
    ZSWIM7 black black black black
    ABCG2 black gray black gray
    FRAS1 turquoise gray turquoise turquoise
    LEPROTL1 black gray black black
    GALNT10 turquoise turquoise gray turquoise
    DTNA turquoise turquoise turquoise turquoise
    TRIP6 turquoise gray turquoise turquoise
    SMPX turquoise turquoise gray turquoise
    RHOF black black black gray
    ADRA2A turquoise turquoise gray turquoise
    SFTA2 turquoise turquoise gray turquoise
    SOX8 turquoise gray turquoise turquoise
    RGS13 black black gray gray
    ADAM22 turquoise turquoise gray turquoise
    DOCK11 turquoise turquoise turquoise turquoise
    KLK6 turquoise turquoise turquoise turquoise
    AKIRIN2 black gray black gray
    CDKN1A black black gray gray
    B4GALT1 black gray black gray
    ITGA9 turquoise gray gray turquoise
    CTSS black gray black black
    KLF13 black black black black
    TMCC3 black gray black gray
    RASGEF1A black black black gray
    LGALS8 black black black black
    ADAMTS15 turquoise gray gray turquoise
    HOXD10 turquoise turquoise gray turquoise
    HOXD11 turquoise turquoise gray turquoise
    OSBPL8 turquoise turquoise gray turquoise
    S100A2 turquoise turquoise turquoise turquoise
    ZNF559 turquoise turquoise turquoise turquoise
    FRZB turquoise gray gray turquoise
    CALB1 black black black black
    GUCY1A2 turquoise turquoise turquoise gray
    METRN black magenta black gray
    SLC46A3 turquoise turquoise gray turquoise
    ARAP3 turquoise turquoise turquoise turquoise
    MPP1 turquoise gray gray turquoise
    IGHD black black gray gray
    GIMAP2 black black black black
    C3orf70 turquoise turquoise turquoise turquoise
    PGBD5 turquoise gray gray turquoise
    ARHGEF26 turquoise gray turquoise turquoise
    SNCAIP turquoise turquoise turquoise turquoise
    HBB turquoise gray turquoise gray
    NT5E black magenta black black
    INTU turquoise turquoise gray turquoise
    ENAH turquoise turquoise turquoise turquoise
    POPDC3 turquoise gray turquoise turquoise
    ST6GALNAC2 black magenta black gray
    SSR3 black gray black black
    SEMA3A turquoise turquoise gray turquoise
    NRN1 turquoise gray gray turquoise
    ADAM17 turquoise gray gray turquoise
    LAMA3 black gray black black
    HHIP turquoise gray turquoise turquoise
    IRAK2 black black gray gray
    HIST2H2BE turquoise turquoise turquoise turquoise
    MLF1 turquoise turquoise turquoise turquoise
    NR4A2 black black black gray
    CRAT turquoise turquoise gray turquoise
    DDIT4 turquoise gray gray turquoise
    PLIN2 turquoise turquoise turquoise turquoise
    PDE10A black gray black black
    FAM228B turquoise turquoise gray turquoise
    IBSP turquoise gray gray gray
    LEPREL1 turquoise turquoise turquoise turquoise
    THRB turquoise turquoise gray turquoise
    OPN3 turquoise turquoise gray turquoise
    EPB41L4A turquoise turquoise turquoise turquoise
    SNCA turquoise turquoise turquoise turquoise
    MAN1A1 turquoise gray turquoise turquoise
    CDA turquoise turquoise turquoise turquoise
    SERPINE2 turquoise turquoise gray turquoise
    GLUD2 black gray gray gray
    MMP1 turquoise gray turquoise gray
    MMP3 turquoise gray turquoise gray
    ETV6 black gray black gray
    KRT6B turquoise turquoise turquoise turquoise
    COPA turquoise turquoise gray turquoise
    ZC2HC1A turquoise turquoise gray turquoise
    SMARCA2 turquoise gray turquoise turquoise
    PHLDA1 turquoise gray gray turquoise
    NQO2 black gray black black
    N4BP2L1 black black gray gray
    ANKRD29 turquoise turquoise turquoise turquoise
    DDX60L black black black black
    TLR3 black black black black
    TNFSF10 black black black black
    IKZF2 black black black black
    PLCL2 black magenta black black
    RAB27A black magenta black black
    PCDHB14 turquoise turquoise turquoise turquoise
    CNTLN black gray black gray
    FAM13A-AS1 turquoise gray gray gray
    DEDD turquoise gray turquoise turquoise
    TNFRSF19 turquoise turquoise turquoise turquoise
    PRKAA2 turquoise turquoise turquoise turquoise
    ADSSL1 turquoise gray gray turquoise
    SRPX2 turquoise turquoise gray turquoise
    SNX19 turquoise gray turquoise turquoise
    CCL26 turquoise gray gray gray
    PELI2 turquoise turquoise turquoise turquoise
    ITGB1BP1 turquoise gray gray turquoise
    EFNA5 turquoise gray gray turquoise
    PRSS23 turquoise gray gray turquoise
    ELP5 black gray black black
    MMP7 turquoise turquoise turquoise turquoise
    VLDLR turquoise turquoise turquoise turquoise
    TMEM220 black black black black
    ARRDC4 turquoise turquoise turquoise turquoise
    INPP5A turquoise gray gray turquoise
    CTSH turquoise gray gray turquoise
    P4HA1 black black black black
    FHOD3 turquoise gray gray turquoise
    JAG1 turquoise gray gray turquoise
    TAC1 turquoise gray gray turquoise
    TJP1 turquoise gray turquoise turquoise
    TRNP1 black magenta black gray
    ULBP2 black magenta black gray
    NELL2 turquoise gray gray turquoise
    ARHGAP4 black black black black
    RASAL2 turquoise gray gray turquoise
    PBX1 turquoise turquoise gray turquoise
    PARVB turquoise gray gray turquoise
    SPRR1A black gray black black
    SPRR1B turquoise gray gray gray
    SPRR3 turquoise turquoise turquoise gray
    MBD1 black gray black gray
    IER5 black magenta black black
    RBP1 turquoise turquoise turquoise turquoise
    PTGES turquoise gray turquoise turquoise
    GALNT18 turquoise gray turquoise turquoise
    WT1 turquoise turquoise turquoise turquoise
    ATF3 turquoise gray gray turquoise
    NR4A1 turquoise gray gray turquoise
    FOS turquoise gray turquoise turquoise
    JUNB turquoise gray turquoise turquoise
    ZFP36 turquoise gray turquoise turquoise
    STAT3 turquoise gray turquoise turquoise
    ZNF415 turquoise turquoise turquoise turquoise
    KRT7 black magenta black gray
    TAPBP black gray black black
    KLK10 black black gray gray
    PPBP turquoise gray turquoise turquoise
    DYNC1H1 turquoise gray gray turquoise
    NAGA black gray black gray
    ZMAT1 turquoise turquoise turquoise turquoise
    TACC1 turquoise turquoise gray turquoise
    TBL1X turquoise gray gray turquoise
    SOD3 turquoise turquoise turquoise turquoise
    HEXIM1 black black black gray
    TET1 turquoise turquoise turquoise turquoise
    PEG10 turquoise gray turquoise turquoise
    DENND5B black black gray gray
    DKK1 turquoise turquoise turquoise turquoise
    ZNF329 turquoise turquoise turquoise turquoise
    C4orf32 black black black black
    LYN black black gray gray
    NRXN3 turquoise turquoise turquoise turquoise
    EXOC6B turquoise gray turquoise turquoise
    LOXL1-AS1 turquoise gray gray turquoise
    WASF3 turquoise turquoise gray turquoise
    DMD turquoise turquoise gray turquoise
    SAR1A turquoise gray gray turquoise
    TGFBR3 turquoise turquoise gray turquoise
    MUM1 turquoise gray gray turquoise
    SESTD1 turquoise gray gray turquoise
    ODAM turquoise turquoise turquoise turquoise
    OR51E1 turquoise turquoise turquoise turquoise
    TSHZ2 turquoise turquoise gray turquoise
    P2RX5 black black black black
    TMC8 black black black black
    DPP7 turquoise gray gray gray
    SPIRE1 turquoise gray turquoise turquoise
    ERO1LB black black black black
    PAX5 black black black black
    LAMC2 turquoise turquoise turquoise turquoise
    LYZ black black black black
    FOSL2 black gray gray gray
    NEFL turquoise turquoise turquoise turquoise
    ALKBH5 black gray black gray
    MKX turquoise turquoise turquoise turquoise
    SLC16A3 black gray black black
    AFAP1L2 black magenta black black
    PPP1R3B turquoise gray turquoise turquoise
    CYP2U1 turquoise turquoise turquoise turquoise
    LPAR6 turquoise turquoise turquoise turquoise
    FAM107B black black black black
    KRT6A turquoise turquoise turquoise turquoise
    FGF13 turquoise turquoise gray turquoise
    SCEL turquoise turquoise turquoise turquoise
    DST turquoise gray turquoise turquoise
    SALL4 turquoise turquoise gray turquoise
    TGFBR2 turquoise gray gray turquoise
    SST turquoise gray turquoise turquoise
    FNDC3B turquoise gray turquoise turquoise
    TUBB2B turquoise turquoise turquoise turquoise
    ZMAT3 turquoise turquoise gray turquoise
    SERPINA3 turquoise gray turquoise turquoise
    FLCN black gray black black
    PFN2 turquoise turquoise turquoise turquoise
    SLCO3A1 turquoise turquoise turquoise turquoise
    AHR black magenta gray gray
    COL27A1 turquoise gray turquoise turquoise
    SERTAD4 turquoise turquoise turquoise turquoise
    ANPEP black black black black
    SOCS1 black black black black
    F5 black black gray gray
    SLC16A10 turquoise gray gray turquoise
    AIF1L black black black gray
    GABBR1 turquoise gray gray turquoise
    FGD6 black black black gray
    ADM black black black black
    ARRDC3 turquoise turquoise turquoise turquoise
    RHOD turquoise turquoise turquoise turquoise
    IL1B black black black black
    PROK2 black black black black
    CXCL5 turquoise gray gray turquoise
    IL24 turquoise gray turquoise turquoise
    FFAR2 black black black black
    CDKN2A turquoise turquoise turquoise turquoise
    LAIR2 black black black black
    IRF5 turquoise gray turquoise turquoise
    HSPA12A turquoise turquoise turquoise turquoise
    LDLRAD4 turquoise gray gray turquoise
    CXCL6 turquoise gray turquoise gray
    SLC22A4 turquoise gray turquoise turquoise
    PROS1 turquoise turquoise turquoise turquoise
    ARHGAP6 turquoise turquoise turquoise turquoise
    TYRP1 turquoise gray turquoise turquoise
    PYGL black black black black
    PDE3A turquoise turquoise gray turquoise
    BNIP3 turquoise turquoise turquoise turquoise
    CDC42BPA turquoise turquoise turquoise turquoise
    RAB30 turquoise turquoise turquoise turquoise
    NOTCH2NL turquoise turquoise turquoise turquoise
    LTF black gray gray black
    11-Sep turquoise gray gray turquoise
    EVA1A turquoise turquoise gray turquoise
    TM4SF1 turquoise gray turquoise turquoise
    MRPS21 black black black black
    WWC3 turquoise turquoise gray turquoise
    LPL turquoise turquoise turquoise turquoise
    SLC16A4 turquoise turquoise turquoise turquoise
    KLF7 turquoise turquoise gray turquoise
    MICB black magenta black black
    PDK4 turquoise turquoise turquoise turquoise
    IGF2 turquoise turquoise turquoise turquoise
    ADA black black black black
    PARP8 black black black black
    FAM127B turquoise gray gray turquoise
    UCP2 black black black black
    FAM120C turquoise turquoise gray turquoise
    C3orf14 turquoise turquoise turquoise turquoise
    RHOBTB1 turquoise turquoise turquoise turquoise
    SACS turquoise gray gray turquoise
    GNA15 black black black black
    SCG5 turquoise gray turquoise turquoise
    MAGED1 turquoise turquoise gray turquoise
    SOCS2 turquoise gray gray turquoise
    TLR4 turquoise gray turquoise turquoise
    FKBP5 black gray black gray
    SAMD3 black black black black
    IGHG1 black black black black
    FAM46C black black black black
    ANKRD36BP2 black black black black
    KLRB1 black black black black
    IGJ black black black black
    FCRL5 black black black black
    CD79A black black black black
    PNOC black black gray black
    IGHM black black black black
    IGKC black black black black
    DERL3 black black black black
    TNFRSF17 black black black black
    POU2AF1 black black black black
    GUSBP11 black black black black
    IGLL3P black black black black
    MZB1 black black black black
    PTK7 turquoise gray turquoise turquoise
    MAP3K6 black magenta black gray
    PPFIBP1 black gray gray gray
    COL4A4 turquoise turquoise turquoise turquoise
    DUSP3 turquoise gray gray turquoise
    CP black black black gray
    CERK turquoise turquoise gray turquoise
    SMOC2 turquoise turquoise turquoise turquoise
    RARRES1 black black black black
    SAV1 black black black gray
    MT1M black black black black
    MT1E black black black black
    MT2A black black black black
    MT1F black black black black
    MT1H black black black black
    MT1G black black black black
    MT1X black black black black
    SLC2A10 turquoise turquoise turquoise turquoise
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    SGCB turquoise gray gray turquoise
    SERPINI1 turquoise turquoise turquoise turquoise
    RARA turquoise gray gray turquoise
    CIRBP turquoise gray gray turquoise
    EVC turquoise turquoise turquoise turquoise
    GNAI1 turquoise turquoise turquoise turquoise
    PLA2G16 turquoise turquoise gray turquoise
    PTGS2 turquoise gray turquoise turquoise
    CXCL16 black black black black
    LEPREL4 turquoise gray turquoise turquoise
    KIT turquoise gray gray turquoise
    SMIM3 turquoise turquoise gray turquoise
    TMEM173 black black gray gray
    SLC9B2 turquoise gray gray turquoise
    ST20 black gray gray black
    BMPR1B turquoise turquoise turquoise turquoise
    KCTD1 black black black gray
    ZFP37 turquoise turquoise gray turquoise
    B2M black black black gray
    PNMA2 black black black gray
    MMP12 black black black black
    NOV turquoise turquoise turquoise turquoise
    CHFR turquoise gray turquoise turquoise
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    CCDC109B black magenta black black
    BCL2 black black black black
    BTN3A2 black black black black
    IL32 black black black gray
    STK17B black black black black
    FAS black magenta black black
    IL15 black black black black
    BIRC3 black black black black
    STK17A black black black black
    JAK2 black black black black
    TNFAIP8 black black black black
    FBXO6 black black black black
    EPSTI1 black black black black
    RNF213 black gray black black
    BATF2 black black black gray
    PSMB10 black gray black black
    ISG20 black black black black
    IFI27 black black black black
    OASL black black black black
    SECTM1 black black black black
    HLA-F black black black black
    IFIT5 black black black black
    IFI6 black black black black
    ETV7 black black black gray
    APOL6 black black black black
    RTP4 black black black black
    DDX60 black black black black
    SAMD9 black black black black
    AIM2 black black black black
    TAP2 black black black black
    LAMP3 black black black black
    CXCL11 black black black black
    NLRC5 black black black black
    ODF3B black black black black
    TRIM69 black black black black
    IRF7 black black black black
    IFIH1 black black black black
    MX2 black black black black
    OAS3 black black black black
    IFI35 black black black black
    USP18 black black black black
    HERC6 black black black black
    ISG15 black black black black
    PARP14 black black black black
    PARP9 black black black black
    SAMD9L black black black black
    XAF1 black black black black
    IFIT1 black black gray gray
    IFIT2 black black black black
    RSAD2 black black black black
    IFI44 black black black black
    CMPK2 black black black black
    OAS2 black black black black
    IFI44L black black black black
    IFIT3 black black black black
    MX1 black black black black
    IRF9 black black black black
    LAP3 black black black black
    WARS black black black black
    IRF1 black black black black
    PSMB9 black black black black
    TAP1 black black black black
    STAT1 black black black black
    UBE2L6 black black black black
    PKIA turquoise turquoise turquoise turquoise
    SLCO2A1 turquoise gray turquoise turquoise
    MAST4 turquoise turquoise turquoise turquoise
    CGNL1 turquoise turquoise turquoise turquoise
    SLC7A2 turquoise turquoise turquoise turquoise
    SERPINB2 black black gray gray
    CTLA4 black black black black
    MAFF turquoise gray gray turquoise
    PDGFD turquoise turquoise turquoise turquoise
    TUBB2A black black black gray
    EPHA7 turquoise turquoise turquoise turquoise
    GHR turquoise turquoise turquoise turquoise
    PCDH18 turquoise gray turquoise turquoise
    FOXF2 turquoise gray turquoise turquoise
    NKX2-3 turquoise gray turquoise turquoise
    SYNGR3 black black black gray
    TRERF1 black black black gray
    S100A13 turquoise gray turquoise turquoise
    LIMCH1 turquoise turquoise turquoise turquoise
    BNIP3L black black black gray
    EVA1C turquoise turquoise gray turquoise
    LAMA5 turquoise turquoise turquoise turquoise
    EDNRB turquoise gray turquoise turquoise
    BANK1 black black black black
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    CST1 turquoise turquoise turquoise turquoise
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    FOXP2 turquoise turquoise gray turquoise
    ZNF134 turquoise turquoise turquoise turquoise
    ARNT2 turquoise gray gray turquoise
    MUM1L1 turquoise turquoise turquoise turquoise
    SCRN1 turquoise turquoise turquoise turquoise
    ZNF880 turquoise turquoise turquoise turquoise
    NINL turquoise gray gray turquoise
    PCNX turquoise gray gray turquoise
    ARHGAP28 turquoise turquoise turquoise turquoise
    TP53INP2 turquoise gray turquoise turquoise
    CFD black black black black
    SNX20 black black black black
    ERRFI1 turquoise gray gray turquoise
    MEGF6 turquoise turquoise gray turquoise
    RAI2 turquoise turquoise turquoise turquoise
    FAXC turquoise turquoise turquoise turquoise
    CASP4 black black black black
    LCK black black black black
    NCALD turquoise gray turquoise turquoise
    CR2 black black gray black
    MS4A1 black black black black
    BAG3 turquoise gray gray turquoise
    FMO3 turquoise gray turquoise turquoise
    SLC16A7 turquoise turquoise gray turquoise
    TXNIP turquoise turquoise gray turquoise
    LXN black gray black black
    ACSL1 turquoise gray turquoise turquoise
    GLUL black black black black
    HSPA2 turquoise turquoise turquoise turquoise
    EGFL6 turquoise gray turquoise gray
    TEAD2 turquoise gray turquoise turquoise
    TLE4 turquoise turquoise turquoise turquoise
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    ELL2 black black black black
    PIK3R5 black black black gray
    DUSP10 turquoise gray gray turquoise
    ANO1 turquoise gray gray turquoise
    KCNS3 turquoise turquoise gray turquoise
    PCDHB2 turquoise turquoise turquoise turquoise
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    LRMP black black black black
    FTH1 black gray gray gray
    SPATS2L black gray black gray
    ZFP82 turquoise turquoise turquoise turquoise
    FBN2 turquoise turquoise turquoise turquoise
    PDZD2 turquoise gray turquoise turquoise
    TMEM200A turquoise turquoise turquoise turquoise
    L1CAM turquoise turquoise gray turquoise
    BHLHE40 turquoise gray turquoise turquoise
    CAPG black black black black
    ULK2 turquoise turquoise turquoise turquoise
    PDLIM5 turquoise turquoise gray turquoise
    RBM24 turquoise turquoise turquoise turquoise
    RAB3B turquoise gray turquoise turquoise
    UBASH3B black black black black
    SNX24 turquoise gray gray gray
    GAS2L1 black black black gray
    HOTAIRM1 turquoise turquoise turquoise turquoise
    CPE turquoise turquoise gray turquoise
    LY6E black black black black
    FKBP1A turquoise gray turquoise turquoise
    CD1D black black black gray
    ST6GAL2 turquoise turquoise gray turquoise
    PTPN21 turquoise turquoise turquoise turquoise
    NGFRAP1 turquoise turquoise turquoise turquoise
    RIN2 turquoise gray turquoise turquoise
    FPR2 black black black black
    INHBB turquoise turquoise turquoise turquoise
    LYST turquoise turquoise gray turquoise
    APOL1 black black black black
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    IGFL2 turquoise turquoise turquoise turquoise
    CDH19 turquoise turquoise turquoise turquoise
    ZKSCAN7 turquoise turquoise turquoise turquoise
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    GAP43 turquoise turquoise turquoise turquoise
    CFI turquoise turquoise turquoise turquoise
    AOX1 turquoise turquoise turquoise turquoise
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    IL1RAP turquoise gray turquoise turquoise
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    TRIL turquoise turquoise turquoise turquoise
    GRB10 turquoise turquoise turquoise turquoise
    ASPA turquoise turquoise turquoise turquoise
    WNT5A turquoise turquoise turquoise turquoise
    PCDHB16 turquoise turquoise turquoise turquoise
    C9orf3 turquoise gray turquoise turquoise
    CARD6 black gray gray gray
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    CTSC black black black black
    GREM2 turquoise gray turquoise turquoise
    KCTD15 turquoise turquoise gray turquoise
    OSBPL1A turquoise turquoise gray turquoise
    CX3CL1 black black black black
    MARCKS turquoise gray gray turquoise
    HES4 turquoise gray gray turquoise
    IKZF1 black black black black
    GAA turquoise gray gray turquoise
    FBXL2 turquoise turquoise turquoise turquoise
    MCL1 turquoise gray gray turquoise
    MR1 black gray black black
    TMEM163 turquoise turquoise turquoise gray
    CXCR2 black black black black
    TLR7 black gray gray black
    GLIS3 turquoise turquoise turquoise turquoise
    FOSB turquoise gray turquoise turquoise
    MAP3K8 black black black black
    FAM43A turquoise gray gray turquoise
    RHOB turquoise gray gray turquoise
    CST2 turquoise turquoise turquoise turquoise
    CPM black gray black gray
    WASF1 turquoise gray gray turquoise
    CPNE8 turquoise turquoise turquoise turquoise
    FAIM3 black black black black
    CLC black black gray black
    GRK5 turquoise turquoise turquoise turquoise
    FDCSP black black gray black
    SOAT1 turquoise gray turquoise turquoise
    ENO2 turquoise gray gray turquoise
    MAGI2 turquoise turquoise turquoise turquoise
    SDC3 turquoise gray gray turquoise
    MIAT black black black black
    ADAM28 black black black black
    SLC11A1 black black gray gray
    FZD7 turquoise turquoise turquoise turquoise
    RGS5 turquoise gray turquoise turquoise
    CNN3 turquoise gray gray turquoise
    MAX black gray black black
    S100A12 black black black black
    PTPLA turquoise gray turquoise turquoise
    SLC2A5 black black black black
    RNASE1 black black black gray
    ANGPT2 turquoise gray turquoise turquoise
    KLF12 turquoise turquoise turquoise turquoise
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    NUPR1 turquoise turquoise gray turquoise
    F8 turquoise turquoise turquoise turquoise
    LEPR turquoise turquoise turquoise turquoise
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    RNF217 turquoise turquoise turquoise turquoise
    GNAL turquoise turquoise turquoise turquoise
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    C16orf54 black black black black
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    HLA-DQA1 black black black black
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    SNX10 black black black black
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    CR1 black black gray black
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    UST turquoise turquoise gray turquoise
    RNF144B black black black black
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    S100B black black black gray
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    IL1RN black black black black
    OSM black black black black
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    PLTP turquoise gray turquoise turquoise
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    DPYSL2 turquoise turquoise turquoise turquoise
    CORIN turquoise turquoise gray turquoise
    LSAMP turquoise turquoise turquoise turquoise
    MMRN1 turquoise turquoise turquoise turquoise
    RCAN1 turquoise turquoise turquoise turquoise
    ADH1B turquoise turquoise turquoise turquoise
    ABCA8 turquoise turquoise turquoise turquoise
    TMEM100 turquoise turquoise turquoise turquoise
    HSPB6 turquoise turquoise turquoise turquoise
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    DAPK1 black gray black gray
    RIT1 black gray black black
    AMIGO2 turquoise turquoise gray turquoise
    CPED1 turquoise gray turquoise turquoise
    ACTB turquoise gray gray turquoise
    CLIC6 turquoise turquoise turquoise turquoise
    MAOB turquoise turquoise turquoise turquoise
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    TDO2 black gray gray black
    FOXO1 turquoise turquoise turquoise turquoise
    TM4SF18 turquoise turquoise turquoise turquoise
    FMOD turquoise turquoise turquoise turquoise
    PDE5A turquoise turquoise turquoise turquoise
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    LPP turquoise turquoise gray turquoise
    VIP turquoise turquoise turquoise turquoise
    TMEM158 turquoise turquoise turquoise turquoise
    RAB23 turquoise turquoise turquoise turquoise
    ARHGAP29 turquoise turquoise turquoise turquoise
    BLVRA black black black black
    ZBTB20 turquoise gray gray turquoise
    CCL11 turquoise gray turquoise turquoise
    PLAUR black black black black
    RAMP1 turquoise turquoise gray turquoise
    PCED1B turquoise gray gray turquoise
    CDKN2B turquoise turquoise turquoise turquoise
    NR2F2 turquoise gray turquoise turquoise
    NFIC turquoise gray gray turquoise
    FGF2 turquoise turquoise turquoise turquoise
    SSBP2 turquoise turquoise turquoise turquoise
    LPAR1 turquoise turquoise turquoise turquoise
    FSCN1 turquoise turquoise gray turquoise
    TNFAIP3 black black black black
    KCNJ15 turquoise gray gray gray
    CSGALNACT1 turquoise turquoise turquoise turquoise
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    PTX3 turquoise gray turquoise turquoise
    CX3CR1 turquoise turquoise turquoise turquoise
    SOBP turquoise turquoise turquoise turquoise
    PDZRN3 turquoise turquoise turquoise turquoise
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    EMP1 turquoise turquoise turquoise turquoise
    LIFR turquoise turquoise turquoise turquoise
    LEF1 turquoise turquoise turquoise turquoise
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    SPON1 turquoise turquoise turquoise turquoise
    HPGDS turquoise turquoise gray turquoise
    GSN turquoise gray turquoise turquoise
    IL6 turquoise gray turquoise turquoise
    CITED2 black gray black gray
    PRDM1 black black black black
    TANC2 turquoise turquoise gray turquoise
    IL6ST turquoise turquoise turquoise turquoise
    ANXA1 black gray black gray
    G0S2 black black gray black
    GPRC5B turquoise turquoise turquoise turquoise
    ROR1 turquoise turquoise gray turquoise
    TRIM6 turquoise turquoise turquoise turquoise
    GLIPR1 turquoise turquoise turquoise turquoise
    CTSO turquoise turquoise gray turquoise
    RGCC turquoise turquoise turquoise turquoise
    STC1 turquoise turquoise turquoise turquoise
    HECTD2 turquoise turquoise turquoise turquoise
    RASA3 turquoise turquoise turquoise turquoise
    MCTP1 turquoise turquoise gray turquoise
    NRP2 turquoise turquoise gray turquoise
    CMAHP turquoise turquoise turquoise turquoise
    CPA3 turquoise turquoise turquoise turquoise
    MAP4K4 turquoise turquoise turquoise turquoise
    IRAK3 black gray black gray
    PLA1A turquoise gray turquoise turquoise
    FAM63B turquoise turquoise gray turquoise
    TRIB2 black black black black
    KLF9 turquoise turquoise gray turquoise
    PRNP turquoise turquoise turquoise turquoise
    ALDH1L2 turquoise turquoise turquoise turquoise
    CALB2 turquoise turquoise turquoise turquoise
    CCDC102B turquoise turquoise turquoise turquoise
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    TPP1 turquoise gray turquoise turquoise
    TPSAB1 turquoise gray turquoise turquoise
    CD36 black gray gray gray
    RRAGD turquoise turquoise gray turquoise
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    FZD2 turquoise turquoise gray turquoise
    PTGDS turquoise turquoise turquoise turquoise
    ABI3BP turquoise turquoise turquoise turquoise
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    GNB4 black gray black black
    IKBIP black black black gray
    CHI3L1 turquoise turquoise turquoise gray
    SOD2 black black black black black
    TYMP black black black black black
    BST2 black black black black black
    CCL19 black black black black black
    FCRL3 black black black black black
    CD80 black black black black black
    VNN2 black black black black black
    FMO1 black gray gray gray black
    LGMN black black black black black
    ZBED2 black black black black black
    PIK3AP1 black black black black black
    SLFN12 black gray black gray black
    LAX1 black black black black black
    GNLY black black black black black
    TNFAIP2 black black black black black
    SH2D1A black black black black black
    IL18RAP black black black black black
    IFI16 black black black black black
    EPB41L3 black black black gray black
    RAB8B black gray black black black
    RUNX3 black black black black black
    HS3ST3B1 black black black black black
    SP110 black black black black black
    IL7R black black black black black
    NCF4 black black black black black
    RGS1 black black black black black
    ITM2A black black black black black
    AQP9 black black black black black
    CLEC5A black black gray gray black
    TREM1 black black black black black
    SCPEP1 black black black black black
    NPC2 black gray black black black
    LRRK2 black black gray black black
    ITGA4 black black gray black black
    KYNU black black black black black
    HLA-DOB black black black black black
    SDS black black black black black
    CSF3R black black black black black
    TIAM1 black black black gray black
    S100A8 black black black black black
    FCN1 black black gray black black
    RARRES3 black black black black black
    CCR7 black black black black black
    STAT2 black gray black black black
    NFATC1 black gray black gray black
    HMOX1 black black black black black
    IDO1 black black black black black
    THEMIS black black black black black
    PRF1 black black black black black
    NPL black black black black black
    TRAT1 black black black black black
    CPVL black black gray black black
    CCL13 black black black black black
    SAMHD1 black black black black black
    MMP9 black black black black black
    TRIM22 black black black black black
    BTN3A3 black black black black black
    PLCG2 black black black black black
    CST7 black black black black black
    SLC7A7 black black black black black
    STX11 black black black black black
    NAPSB black black black gray black
    ANKRD44 black black black black black
    FGL2 black black black black black
    RGS18 black black black black black
    CD40 black black black black black
    GPR84 black black black black black
    FAM65B black black black black black
    CXCL10 black black black black black
    GBP2 black black black black black
    ITGB2-AS1 black black black black black
    HSD11B1 black black black gray black
    ADORA3 black black black black black
    CYTIP black black black black black
    ENPP2 black black black black black
    ATP8B4 black black black black black
    GZMA black black black black black
    EOMES black black black black black
    GBP4 black black black black black
    CD69 black black black black black
    CXCR4 black black black black black
    GPR34 black gray black black black
    ARHGDIB black black black black black
    GBP1 black black black black black
    CD38 black black black black black
    BCL2A1 black black black black black
    JAK3 black black black black black
    CORO1A black black black black black
    CD274 black black black black black
    RASGRP1 black black black black black
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    APOL3 black black black black black
    PLEK black black black black black
    EMR2 black black black black black
    CD27 black black black black black
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    PPP1R16B black black black black black
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    GNG2 black black black gray black
    GPR183 black black black black black
    CYSLTR1 black black black black black
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    APOE black black black black black
    ITGAX black black black black black
    RAC2 black black black black black
    GM2A black gray black black black
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    CXCL13 black black black black black
    CCL8 black black black black black
    CXCL9 black black black black black
    GGTA1P black black black black black
    NLRC3 black black black black black
    FPR1 black black black black black
    APOC1 black black black black black
    GPR171 black black black black black
    GIMAP7 black black black black black
    RHOH black black black black black
    ICAM1 black black black black black
    VAMP5 black black black black black
    KLRD1 black black black black black
    TMEM140 black black black black black
    TLR2 black black black black black
    CLEC4E black black black black black
    SLC1A3 black black black black black
    CLIC2 black black black black black
    CCR2 black black black black black
    ITGAL black black black black black
    GZMH black black black black black
    IL4I1 black black black black black
    SUCNR1 black black black black black
    SELL black black black black black
    IL2RA black black black black black
    CCL18 black black black black black
    ITK black black black black black
    NKG7 black black black black black
    CECR1 black black black black black
    CD8A black black black black black
    ST8SIA4 black black black black black
    CCL4 black black black black black
    APOBEC3G black black black black black
    EVL black black black black black
    IL18BP black black black black black
    PIK3CG black black black black black
    FCGR3B black black black black black
    C5AR1 black black black black black
    FCGR2C black black black black black
    ALOX5AP black black black black black
    ARL4C black gray gray gray black
    VCAM1 black black gray gray black
    MSR1 black black black black black
    TM6SF1 black black black black black
    DSE black gray gray black black
    NR3C1 black black gray gray black
    MRC1 black black black black black
    NRP1 black gray black gray black
    ZEB2 black gray gray gray black
    FGR black black black black black
    KMO black black black black black
    DOK3 black black black black black
    DPYD black black black black black
    CLEC4A black black black black black
    CLEC2B black black black black black
    SLAMF7 black black black black black
    HLA-DMA black black black black black
    SLC15A3 black black black black black
    PIK3CD black black black black black
    KLHL6 black black black black black
    SAMSN1 black black black black black
    TRAF3IP3 black black black black black
    CCL5 black black black black black
    ARHGAP15 black black black black black
    CD72 black black black black black
    IL2RB black black black black black
    MS4A7 black black black black black
    1-Mar black black black black black
    GBP5 black black black black black
    CD74 black black black black black
    FAM49A black black black black black
    PRKCB black black black black black
    FYB black black black black black
    GZMK black black black black black
    FAM26F black black black black black
    SLC31A2 black black black black black
    P2RY13 black black black black black
    GIMAP8 black black black black black
    HLA-DOA black black black black black
    TLR1 black black black black black
    PTPRC black black black black black
    LY86 black black black black black
    LILRB2 black black black black black
    DOCK10 black black black black black
    SRGN black black black black black
    CD2 black black black black black
    RASSF5 black black black black black
    HLA-DQB1 black black black black black
    GIMAP1 black black black black black
    THEMIS2 black black black black black
    ACP5 black black black black black
    TFEC black black black black black
    FCGR2B black black black black black
    MPEG1 black black black black black
    GPR65 black black black black black
    HLA-DPA1 black black black black black
    TNFSF13B black black black black black
    LILRB4 black black black black black
    VSIG4 black black black black black
    FCGR2A black black black black black
    NCF2 black black black black black
    ITGAM black black black black black
    CHST11 black black black black black
    PILRA black black black black black
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    CD52 black black black black black
    TRAC black black black black black
    EVI2A black black black black black
    MYO1F black black black black black
    FLI1 black black black gray black
    RCSD1 black black black black black
    C10orf128 black black black black black
    CCR5 black black black black black
    CYBB black black black black black
    SIGLEC10 black black black black black
    CSF2RB black black black black black
    ARHGEF6 black black black gray black
    WIPF1 black black black gray black
    CD37 black black black black black
    PLA2G7 black black black black black
    EVI2B black black black black black
    ARHGAP9 black black black black black
    HAVCR2 black black black black black
    IGSF6 black black black black black
    HLA-DRA black black black black black
    GMFG black black black black black
    IL10RA black black black black black
    SASH3 black black black black black
    LCP1 black black black black black
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    LY96 black black black black black
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    CD14 black black black black black
    CCR1 black black black black black
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    CD300LF black black black black black
    CD163 black black black black black
    GPNMB black black black black black
    TLR8 black black black black black
    HLA-DMB black black black black black
    MS4A4A black black black black black
    CD84 black black black black black
    NCKAP1L black black black black black
    APBB1IP black black black black black
    DOCK2 black black black black black
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    CD48 black black black black black
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    C1QC black black black black black
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    MAFB black black black black black
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    HCK black black black black black
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    CD53 black black black black black
    C1QB black black black black black
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    ECM1 turquoise turquoise turquoise turquoise turquoise
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    HSPB1 turquoise turquoise turquoise turquoise turquoise
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    OBSL1 turquoise turquoise turquoise turquoise turquoise
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    FRY turquoise turquoise turquoise turquoise turquoise
    MAP9 turquoise turquoise turquoise turquoise turquoise
    CD99 turquoise turquoise turquoise turquoise turquoise
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    TCF21 turquoise gray turquoise turquoise turquoise
    PI15 turquoise turquoise turquoise turquoise turquoise
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    CCDC69 turquoise gray turquoise turquoise turquoise
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    KCTD12 turquoise turquoise gray turquoise turquoise
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    MCC turquoise turquoise turquoise turquoise turquoise
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    SDPR turquoise turquoise turquoise turquoise turquoise
    SVIL turquoise gray turquoise turquoise turquoise
    SLC8A1 turquoise gray turquoise turquoise turquoise
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    PGM5 turquoise turquoise turquoise turquoise turquoise
    RORA turquoise turquoise turquoise turquoise turquoise
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    HIP1 turquoise turquoise turquoise turquoise turquoise
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    ATXN1 turquoise turquoise turquoise turquoise turquoise
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    FAM198B turquoise turquoise turquoise turquoise turquoise
    PPAP2A turquoise turquoise turquoise turquoise turquoise
    FZD8 turquoise turquoise turquoise turquoise turquoise
    PLA2G5 turquoise turquoise turquoise turquoise turquoise
    PTN turquoise turquoise turquoise turquoise turquoise
    PRKG1 turquoise turquoise gray turquoise turquoise
    RTN1 turquoise turquoise gray turquoise turquoise
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    FILIP1 turquoise turquoise turquoise turquoise turquoise
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    BCHE turquoise turquoise turquoise turquoise turquoise
    PCSK5 turquoise turquoise turquoise turquoise turquoise
    LINC00341 turquoise turquoise gray turquoise turquoise
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    CLU turquoise turquoise turquoise turquoise turquoise
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    HOXB2 turquoise turquoise gray turquoise turquoise
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    GPM6B turquoise turquoise turquoise turquoise turquoise
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    C7 turquoise turquoise gray turquoise turquoise
    FBXO32 turquoise turquoise turquoise turquoise turquoise
    MEIS2 turquoise turquoise gray turquoise turquoise
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    IGDCC4 turquoise turquoise turquoise turquoise turquoise
    NOTCH2 turquoise gray turquoise turquoise turquoise
    SMARCA1 turquoise turquoise turquoise turquoise turquoise
    SELP turquoise turquoise turquoise turquoise turquoise
    ADAM19 turquoise turquoise turquoise turquoise turquoise
    CDO1 turquoise turquoise turquoise turquoise turquoise
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    RNF144A turquoise turquoise gray turquoise turquoise
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    BCL6 turquoise gray gray turquoise turquoise
    PAPPA turquoise turquoise turquoise turquoise turquoise
    GPR161 turquoise turquoise turquoise turquoise turquoise
    KLF2 turquoise turquoise turquoise turquoise turquoise
    CAV2 turquoise turquoise turquoise turquoise turquoise
    HEY1 turquoise turquoise turquoise turquoise turquoise
    FYN turquoise turquoise gray turquoise turquoise
    FAM13C turquoise turquoise turquoise turquoise turquoise
    TMTC1 turquoise turquoise turquoise turquoise turquoise
    PPP1R12B turquoise turquoise turquoise turquoise turquoise
    PGM5-AS1 turquoise gray turquoise turquoise turquoise
    OGN turquoise turquoise turquoise turquoise turquoise
    C2orf40 turquoise turquoise turquoise turquoise turquoise
    ANGPTL1 turquoise turquoise turquoise turquoise turquoise
    MAMDC2 turquoise turquoise turquoise turquoise turquoise
    TCEAL2 turquoise turquoise turquoise turquoise turquoise
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    CHRDL1 turquoise turquoise turquoise turquoise turquoise
    PDZRN4 turquoise turquoise turquoise turquoise turquoise
    SCN7A turquoise turquoise turquoise turquoise turquoise
    FHL1 turquoise turquoise turquoise turquoise turquoise
    ANK2 turquoise turquoise turquoise turquoise turquoise
    LMO3 turquoise turquoise turquoise turquoise turquoise
    C5orf46 turquoise turquoise turquoise turquoise turquoise
    FAM171B turquoise turquoise turquoise turquoise turquoise
    SCUBE2 turquoise turquoise turquoise turquoise turquoise
    GPR133 turquoise turquoise turquoise turquoise turquoise
    RDX turquoise turquoise turquoise turquoise turquoise
    CD109 turquoise turquoise turquoise turquoise turquoise
    ROBO1 turquoise turquoise turquoise turquoise turquoise
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    AGTR1 turquoise turquoise turquoise turquoise turquoise
    SETBP1 turquoise turquoise turquoise turquoise turquoise
    LYVE1 turquoise turquoise turquoise turquoise turquoise
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    CBX6 turquoise turquoise gray turquoise turquoise
    COL16A1 turquoise turquoise turquoise turquoise turquoise
    MAN1C1 turquoise turquoise turquoise turquoise turquoise
    GXYLT2 turquoise turquoise turquoise turquoise turquoise
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    ZNF331 turquoise turquoise turquoise turquoise turquoise
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    BEX4 turquoise turquoise turquoise turquoise turquoise
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    RGL1 turquoise turquoise turquoise turquoise turquoise
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    FABP4 turquoise turquoise turquoise turquoise turquoise
    EDIL3 turquoise turquoise turquoise turquoise turquoise
    APOD turquoise turquoise turquoise turquoise turquoise
    SLC2A3 turquoise gray turquoise turquoise turquoise
    EMCN turquoise turquoise turquoise turquoise turquoise
    PRR16 turquoise turquoise turquoise turquoise turquoise
    SHANK3 turquoise turquoise gray turquoise turquoise
    PLA2G4C turquoise turquoise turquoise turquoise turquoise
    CSGALNACT2 turquoise turquoise turquoise turquoise turquoise
    FGF7 turquoise turquoise turquoise turquoise turquoise
    TSC22D3 turquoise gray turquoise turquoise turquoise
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    CHRDL2 turquoise turquoise turquoise turquoise turquoise
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    OMD turquoise turquoise turquoise turquoise turquoise
    LINC00312 turquoise turquoise turquoise turquoise turquoise
    LRRC17 turquoise turquoise turquoise turquoise turquoise
    NAV3 turquoise turquoise turquoise turquoise turquoise
    PTGER3 turquoise turquoise turquoise turquoise turquoise
    ROR2 turquoise turquoise turquoise turquoise turquoise
    SPHK1 turquoise gray turquoise turquoise turquoise
    ANKRD6 turquoise turquoise turquoise turquoise turquoise
    SLFN11 turquoise gray gray turquoise turquoise
    STAB1 turquoise turquoise gray turquoise turquoise
    ALPK2 turquoise turquoise turquoise turquoise turquoise
    PLAT turquoise gray turquoise turquoise turquoise
    SOX7 turquoise turquoise turquoise turquoise turquoise
    PPP1R14A turquoise turquoise turquoise turquoise turquoise
    PLAU turquoise turquoise turquoise turquoise turquoise
    CSRP2 turquoise turquoise turquoise turquoise turquoise
    GRP turquoise turquoise turquoise turquoise turquoise
    BHLHE22 turquoise turquoise turquoise turquoise turquoise
    EPHA3 turquoise turquoise turquoise turquoise turquoise
    DIO2 turquoise turquoise turquoise turquoise turquoise
    SCG2 turquoise turquoise turquoise turquoise turquoise
    RGS16 turquoise turquoise gray turquoise turquoise
    ELN turquoise turquoise turquoise turquoise turquoise
    ELK3 turquoise turquoise turquoise turquoise turquoise
    CAP2 turquoise turquoise gray turquoise turquoise
    GPX7 turquoise turquoise turquoise turquoise turquoise
    PDGFRL turquoise turquoise turquoise turquoise turquoise
    UCHL1 turquoise turquoise turquoise turquoise turquoise
    EPYC turquoise turquoise turquoise turquoise turquoise
    ITGB5 turquoise turquoise turquoise turquoise turquoise
    GADD45B turquoise gray turquoise turquoise turquoise
    GLRB turquoise turquoise turquoise turquoise turquoise
    RGS2 turquoise turquoise turquoise turquoise turquoise
    DIP2C turquoise turquoise turquoise turquoise turquoise
    TTC7B turquoise turquoise turquoise turquoise turquoise
    CCDC88A turquoise gray turquoise turquoise turquoise
    SAMD4A turquoise turquoise turquoise turquoise turquoise
    F13A1 turquoise turquoise turquoise turquoise turquoise
    MEOX2 turquoise turquoise turquoise turquoise turquoise
    PRELP turquoise turquoise turquoise turquoise turquoise
    CCL21 turquoise turquoise turquoise turquoise turquoise
    FST turquoise turquoise turquoise turquoise turquoise
    CALCRL turquoise turquoise turquoise turquoise turquoise
    LRRN4CL turquoise turquoise turquoise turquoise turquoise
    ETS1 turquoise gray turquoise turquoise turquoise
    ITPRIP turquoise gray turquoise turquoise turquoise
    SRPX turquoise turquoise turquoise turquoise turquoise
    CHRNA3 turquoise turquoise turquoise turquoise turquoise
    PXDC1 turquoise turquoise turquoise turquoise turquoise
    WNT2 turquoise turquoise turquoise turquoise turquoise
    SERPINE1 turquoise turquoise turquoise turquoise turquoise
    PCDH17 turquoise turquoise turquoise turquoise turquoise
    FAM127A turquoise turquoise turquoise turquoise turquoise
    DACT1 turquoise turquoise turquoise turquoise turquoise
    TMEM45A turquoise turquoise turquoise turquoise turquoise
    NPR3 turquoise turquoise turquoise turquoise turquoise
    SDK1 turquoise turquoise turquoise turquoise turquoise
    CYGB turquoise turquoise turquoise turquoise turquoise
    OLFML2A turquoise gray turquoise turquoise turquoise
    ARL10 turquoise turquoise turquoise turquoise turquoise
    HTR2B turquoise turquoise turquoise turquoise turquoise
    TCEAL3 turquoise turquoise turquoise turquoise turquoise
    MDFIC turquoise turquoise turquoise turquoise turquoise
    PALMD turquoise turquoise turquoise turquoise turquoise
    CILP turquoise turquoise turquoise turquoise turquoise
    AQP1 turquoise turquoise turquoise turquoise turquoise
    CXCL12 turquoise turquoise turquoise turquoise turquoise
    RERG turquoise turquoise turquoise turquoise turquoise
    TCEA2 turquoise turquoise turquoise turquoise turquoise
    PBX3 turquoise turquoise turquoise turquoise turquoise
    GLI3 turquoise turquoise turquoise turquoise turquoise
    DSEL turquoise turquoise turquoise turquoise turquoise
    ADAMTS1 turquoise turquoise turquoise turquoise turquoise
    PTPLAD2 turquoise turquoise turquoise turquoise turquoise
    ALDH1A3 turquoise turquoise turquoise turquoise turquoise
    VWF turquoise turquoise turquoise turquoise turquoise
    ATP2B4 turquoise turquoise turquoise turquoise turquoise
    CFL2 turquoise turquoise turquoise turquoise turquoise
    ZNF677 turquoise turquoise turquoise turquoise turquoise
    RGS4 turquoise turquoise turquoise turquoise turquoise
    GALNT15 turquoise turquoise turquoise turquoise turquoise
    SYNE1 turquoise turquoise gray turquoise turquoise
    CYP1B1 turquoise turquoise turquoise turquoise turquoise
    TUSC3 turquoise turquoise turquoise turquoise turquoise
    ZNF532 turquoise turquoise turquoise turquoise turquoise
    RSPO3 turquoise turquoise turquoise turquoise turquoise
    NAV1 turquoise turquoise turquoise turquoise turquoise
    QKI turquoise gray turquoise turquoise turquoise
    THBS4 turquoise turquoise turquoise turquoise turquoise
    CALU turquoise gray turquoise turquoise turquoise
    STOM turquoise turquoise turquoise turquoise turquoise
    TIMP1 turquoise turquoise turquoise turquoise turquoise
    RASSF8 turquoise turquoise turquoise turquoise turquoise
    RGMA turquoise turquoise turquoise turquoise turquoise
    CPXM2 turquoise turquoise turquoise turquoise turquoise
    BTBD19 turquoise turquoise turquoise turquoise turquoise
    ZCCHC24 turquoise turquoise gray turquoise turquoise
    DENND5A turquoise turquoise turquoise turquoise turquoise
    ELTD1 turquoise turquoise turquoise turquoise turquoise
    LPHN2 turquoise turquoise turquoise turquoise turquoise
    TRPC1 turquoise turquoise turquoise turquoise turquoise
    TPST1 turquoise turquoise turquoise turquoise turquoise
    TGFB1 turquoise gray gray turquoise turquoise
    ISM1 turquoise turquoise turquoise turquoise turquoise
    INMT turquoise turquoise turquoise turquoise turquoise
    MMP11 turquoise turquoise turquoise turquoise turquoise
    LTBP1 turquoise turquoise turquoise turquoise turquoise
    THBS1 turquoise turquoise turquoise turquoise turquoise
    HSD17B6 turquoise turquoise turquoise turquoise turquoise
    NREP turquoise turquoise turquoise turquoise turquoise
    SSPN turquoise turquoise turquoise turquoise turquoise
    C10orf10 turquoise turquoise turquoise turquoise turquoise
    TRPS1 turquoise turquoise turquoise turquoise turquoise
    KLHL5 turquoise turquoise turquoise turquoise turquoise
    ADAMTS5 turquoise turquoise turquoise turquoise turquoise
    SLC24A3 turquoise turquoise turquoise turquoise turquoise
    LMCD1 turquoise turquoise turquoise turquoise turquoise
    ANXA6 turquoise turquoise turquoise turquoise turquoise
    UBE2E2 turquoise turquoise turquoise turquoise turquoise
    C3 turquoise turquoise turquoise turquoise turquoise
    MYO5A turquoise gray turquoise turquoise turquoise
    HSPG2 turquoise turquoise turquoise turquoise turquoise
    CAV1 turquoise turquoise turquoise turquoise turquoise
    PNMAL1 turquoise turquoise turquoise turquoise turquoise
    CLIC4 turquoise turquoise turquoise turquoise turquoise
    DCHS1 turquoise turquoise turquoise turquoise turquoise
    KCNJ8 turquoise turquoise turquoise turquoise turquoise
    EML1 turquoise turquoise turquoise turquoise turquoise
    TP73-AS1 turquoise turquoise gray turquoise turquoise
    SMARCD3 turquoise turquoise turquoise turquoise turquoise
    MEDAG turquoise turquoise turquoise turquoise turquoise
    CCL2 turquoise gray turquoise turquoise turquoise
    CLIP4 turquoise turquoise turquoise turquoise turquoise
    DCLK1 turquoise turquoise turquoise turquoise turquoise
    ARMCX2 turquoise turquoise turquoise turquoise turquoise
    CHST15 turquoise gray turquoise turquoise turquoise
    CALHM2 turquoise turquoise turquoise turquoise turquoise
    C1QTNF3 turquoise turquoise turquoise turquoise turquoise
    JAZF1 turquoise turquoise turquoise turquoise turquoise
    KIF26B turquoise turquoise turquoise turquoise turquoise
    GNG11 turquoise turquoise turquoise turquoise turquoise
    ERG turquoise turquoise turquoise turquoise turquoise
    GJA1 turquoise turquoise turquoise turquoise turquoise
    RBMS1 turquoise turquoise turquoise turquoise turquoise
    CPXM1 turquoise turquoise turquoise turquoise turquoise
    MFAP4 turquoise turquoise turquoise turquoise turquoise
    ITGBL1 turquoise turquoise turquoise turquoise turquoise
    MMRN2 turquoise turquoise turquoise turquoise turquoise
    FZD1 turquoise turquoise turquoise turquoise turquoise
    LATS2 turquoise turquoise turquoise turquoise turquoise
    CDH5 turquoise turquoise turquoise turquoise turquoise
    SGCE turquoise turquoise turquoise turquoise turquoise
    NID1 turquoise turquoise turquoise turquoise turquoise
    RBMS3 turquoise turquoise turquoise turquoise turquoise
    PLXDC2 turquoise turquoise turquoise turquoise turquoise
    CYBRD1 turquoise turquoise turquoise turquoise turquoise
    IGFBP3 turquoise turquoise turquoise turquoise turquoise
    EDNRA turquoise turquoise turquoise turquoise turquoise
    MN1 turquoise turquoise turquoise turquoise turquoise
    HS3ST3A1 turquoise turquoise turquoise turquoise turquoise
    EBF1 turquoise turquoise turquoise turquoise turquoise
    SERPINH1 turquoise gray turquoise turquoise turquoise
    GEM turquoise turquoise turquoise turquoise turquoise
    TNFAIP6 turquoise gray turquoise turquoise turquoise
    KAL1 turquoise turquoise turquoise turquoise turquoise
    RAI14 turquoise turquoise turquoise turquoise turquoise
    HEYL turquoise turquoise turquoise turquoise turquoise
    CFH turquoise turquoise turquoise turquoise turquoise
    PALLD turquoise turquoise turquoise turquoise turquoise
    TNFSF4 turquoise turquoise turquoise turquoise turquoise
    MXRA7 turquoise turquoise turquoise turquoise turquoise
    PDLIM4 turquoise turquoise turquoise turquoise turquoise
    TMEM119 turquoise turquoise turquoise turquoise turquoise
    NID2 turquoise turquoise turquoise turquoise turquoise
    MYH10 turquoise turquoise turquoise turquoise turquoise
    C11orf96 turquoise turquoise turquoise turquoise turquoise
    MOXD1 turquoise turquoise turquoise turquoise turquoise
    SGCD turquoise turquoise turquoise turquoise turquoise
    SYT11 turquoise turquoise turquoise turquoise turquoise
    DPT turquoise turquoise turquoise turquoise turquoise
    COL14A1 turquoise turquoise turquoise turquoise turquoise
    UBE2QL1 turquoise turquoise turquoise turquoise turquoise
    PCDH7 turquoise turquoise turquoise turquoise turquoise
    PLXDC1 turquoise turquoise turquoise turquoise turquoise
    MLLT11 turquoise turquoise turquoise turquoise turquoise
    CLEC11A turquoise turquoise turquoise turquoise turquoise
    PPP1R18 turquoise gray gray turquoise turquoise
    PLEKHO1 turquoise gray gray turquoise turquoise
    EMP3 turquoise gray gray gray turquoise
    TSPAN4 turquoise gray turquoise turquoise turquoise
    FAM19A5 turquoise turquoise turquoise turquoise turquoise
    LBH turquoise turquoise turquoise turquoise turquoise
    PRKCDBP turquoise turquoise turquoise turquoise turquoise
    A2M turquoise turquoise turquoise turquoise turquoise
    COL8A2 turquoise turquoise turquoise turquoise turquoise
    IGFBP6 turquoise turquoise turquoise turquoise turquoise
    SLIT2 turquoise turquoise turquoise turquoise turquoise
    JAM2 turquoise turquoise turquoise turquoise turquoise
    PDLIM7 turquoise turquoise turquoise turquoise turquoise
    GJC1 turquoise turquoise turquoise turquoise turquoise
    MFAP5 turquoise turquoise turquoise turquoise turquoise
    CDK14 turquoise turquoise turquoise turquoise turquoise
    C3orf80 turquoise turquoise turquoise turquoise turquoise
    PHLDB2 turquoise turquoise turquoise turquoise turquoise
    SPG20 turquoise turquoise turquoise turquoise turquoise
    CYS1 turquoise turquoise turquoise turquoise turquoise
    TIE1 turquoise turquoise turquoise turquoise turquoise
    CHSY3 turquoise turquoise turquoise turquoise turquoise
    TNC turquoise turquoise turquoise turquoise turquoise
    PKD2 turquoise turquoise turquoise turquoise turquoise
    FAM129A turquoise gray gray turquoise turquoise
    NEXN turquoise turquoise turquoise turquoise turquoise
    GAS7 turquoise turquoise turquoise turquoise turquoise
    ECM2 turquoise turquoise turquoise turquoise turquoise
    CYR61 turquoise turquoise turquoise turquoise turquoise
    TCF4 turquoise turquoise turquoise turquoise turquoise
    HMCN1 turquoise turquoise turquoise turquoise turquoise
    PTGIS turquoise turquoise turquoise turquoise turquoise
    AKAP12 turquoise turquoise turquoise turquoise turquoise
    TMEM47 turquoise turquoise turquoise turquoise turquoise
    LDB2 turquoise turquoise turquoise turquoise turquoise
    CLMP turquoise turquoise turquoise turquoise turquoise
    MPDZ turquoise turquoise turquoise turquoise turquoise
    CRISPLD1 turquoise turquoise turquoise turquoise turquoise
    DZIP1 turquoise turquoise turquoise turquoise turquoise
    PRICKLE1 turquoise turquoise turquoise turquoise turquoise
    PRICKLE2 turquoise turquoise turquoise turquoise turquoise
    RECK turquoise turquoise turquoise turquoise turquoise
    MAP1B turquoise turquoise turquoise turquoise turquoise
    PPP1R3C turquoise turquoise turquoise turquoise turquoise
    TCEAL7 turquoise turquoise turquoise turquoise turquoise
    SYNM turquoise turquoise turquoise turquoise turquoise
    PDE1A turquoise turquoise turquoise turquoise turquoise
    PEG3 turquoise turquoise turquoise turquoise turquoise
    SYNPO2 turquoise turquoise turquoise turquoise turquoise
    FBLN5 turquoise turquoise turquoise turquoise turquoise
    NAP1L3 turquoise turquoise turquoise turquoise turquoise
    SYNC turquoise turquoise turquoise turquoise turquoise
    ARMCX1 turquoise turquoise turquoise turquoise turquoise
    SPARCL1 turquoise turquoise turquoise turquoise turquoise
    KCNMB1 turquoise turquoise turquoise turquoise turquoise
    CACNA2D1 turquoise turquoise turquoise turquoise turquoise
    C14orf132 turquoise turquoise turquoise turquoise turquoise
    MYH11 turquoise turquoise turquoise turquoise turquoise
    HSPB8 turquoise turquoise turquoise turquoise turquoise
    DES turquoise turquoise turquoise turquoise turquoise
    LMOD1 turquoise turquoise turquoise turquoise turquoise
    ACTG2 turquoise turquoise turquoise turquoise turquoise
    PLN turquoise turquoise turquoise turquoise turquoise
    MAB21L2 turquoise turquoise turquoise turquoise turquoise
    RUNX1T1 turquoise turquoise turquoise turquoise turquoise
    STON1 turquoise turquoise turquoise turquoise turquoise
    BOC turquoise turquoise turquoise turquoise turquoise
    KANK2 turquoise turquoise turquoise turquoise turquoise
    FXYD6 turquoise turquoise turquoise turquoise turquoise
    C20orf194 turquoise turquoise turquoise turquoise turquoise
    PDLIM3 turquoise turquoise turquoise turquoise turquoise
    MGP turquoise turquoise turquoise turquoise turquoise
    AOC3 turquoise turquoise turquoise turquoise turquoise
    AMOTL1 turquoise turquoise turquoise turquoise turquoise
    TPM2 turquoise turquoise turquoise turquoise turquoise
    MRVI1 turquoise turquoise turquoise turquoise turquoise
    TSPYL5 turquoise turquoise turquoise turquoise turquoise
    FEZ1 turquoise turquoise turquoise turquoise turquoise
    CNRIP1 turquoise turquoise turquoise turquoise turquoise
    COX7A1 turquoise turquoise turquoise turquoise turquoise
    MRGPRF turquoise turquoise turquoise turquoise turquoise
    MYLK turquoise turquoise turquoise turquoise turquoise
    CNN1 turquoise turquoise turquoise turquoise turquoise
    CRYAB turquoise turquoise turquoise turquoise turquoise
    FILIP1L turquoise turquoise turquoise turquoise turquoise
    SYNDIG1 turquoise turquoise turquoise turquoise turquoise
    THBD turquoise turquoise turquoise turquoise turquoise
    MMP19 turquoise gray turquoise turquoise turquoise
    DLC1 turquoise turquoise turquoise turquoise turquoise
    WWTR1 turquoise turquoise turquoise turquoise turquoise
    FLNA turquoise turquoise turquoise turquoise turquoise
    CD93 turquoise turquoise turquoise turquoise turquoise
    MMP14 turquoise turquoise turquoise turquoise turquoise
    PRKD1 turquoise turquoise turquoise turquoise turquoise
    NDN turquoise turquoise turquoise turquoise turquoise
    MAGI2-AS3 turquoise turquoise turquoise turquoise turquoise
    COMP turquoise turquoise turquoise turquoise turquoise
    BASP1 turquoise gray turquoise gray turquoise
    SNAI2 turquoise turquoise turquoise turquoise turquoise
    RARRES2 turquoise turquoise turquoise turquoise turquoise
    CTGF turquoise turquoise turquoise turquoise turquoise
    AKT3 turquoise turquoise turquoise turquoise turquoise
    IL1R1 turquoise turquoise turquoise turquoise turquoise
    ST6GALNAC5 turquoise turquoise turquoise turquoise turquoise
    BICC1 turquoise turquoise turquoise turquoise turquoise
    KIRREL turquoise turquoise turquoise turquoise turquoise
    DOK5 turquoise turquoise turquoise turquoise turquoise
    MSN turquoise gray gray turquoise turquoise
    FAM101B turquoise turquoise turquoise turquoise turquoise
    LTBP2 turquoise turquoise turquoise turquoise turquoise
    FBLN2 turquoise turquoise turquoise turquoise turquoise
    LRRC15 turquoise turquoise turquoise turquoise turquoise
    LOX turquoise turquoise turquoise turquoise turquoise
    MFGE8 turquoise turquoise turquoise turquoise turquoise
    FAP turquoise turquoise turquoise turquoise turquoise
    COLEC12 turquoise turquoise turquoise turquoise turquoise
    FAM20C turquoise turquoise turquoise turquoise turquoise
    PTPRM turquoise turquoise turquoise turquoise turquoise
    BCAT1 turquoise turquoise turquoise turquoise turquoise
    MAF turquoise turquoise turquoise turquoise turquoise
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    FGFR1 turquoise turquoise turquoise turquoise turquoise
    S1PR3 turquoise turquoise turquoise turquoise turquoise
    VGLL3 turquoise turquoise turquoise turquoise turquoise
    ITGA5 turquoise turquoise turquoise turquoise turquoise
    PDPN turquoise turquoise turquoise turquoise turquoise
    GREM1 turquoise turquoise turquoise turquoise turquoise
    PMP22 turquoise turquoise turquoise turquoise turquoise
    COL18A1 turquoise turquoise turquoise turquoise turquoise
    PDGFC turquoise turquoise turquoise turquoise turquoise
    FN1 turquoise turquoise turquoise turquoise turquoise
    KCNE4 turquoise turquoise turquoise turquoise turquoise
    GLIS2 turquoise turquoise turquoise turquoise turquoise
    EFEMP1 turquoise turquoise turquoise turquoise turquoise
    ZNF521 turquoise turquoise turquoise turquoise turquoise
    CERCAM turquoise turquoise turquoise turquoise turquoise
    NOX4 turquoise turquoise turquoise turquoise turquoise
    NUAK1 turquoise turquoise turquoise turquoise turquoise
    COL15A1 turquoise turquoise turquoise turquoise turquoise
    CRISPLD2 turquoise turquoise turquoise turquoise turquoise
    LOXL1 turquoise turquoise turquoise turquoise turquoise
    GFPT2 turquoise turquoise turquoise turquoise turquoise
    INHBA turquoise turquoise turquoise turquoise turquoise
    WISP1 turquoise turquoise turquoise turquoise turquoise
    DPYSL3 turquoise turquoise turquoise turquoise turquoise
    ZFPM2 turquoise turquoise turquoise turquoise turquoise
    PPAPDC1A turquoise turquoise turquoise turquoise turquoise
    MITF turquoise turquoise turquoise turquoise turquoise
    KIAA1462 turquoise turquoise turquoise turquoise turquoise
    OLFML1 turquoise turquoise turquoise turquoise turquoise
    FBLN1 turquoise turquoise turquoise turquoise turquoise
    PRRX1 turquoise turquoise turquoise turquoise turquoise
    MFAP2 turquoise turquoise turquoise turquoise turquoise
    TSHZ3 turquoise turquoise turquoise turquoise turquoise
    TWIST1 turquoise turquoise turquoise turquoise turquoise
    POSTN turquoise turquoise turquoise turquoise turquoise
    MRAS turquoise turquoise turquoise turquoise turquoise
    IGFBP7 turquoise turquoise turquoise turquoise turquoise
    TGFB1I1 turquoise turquoise turquoise turquoise turquoise
    NOTCH3 turquoise turquoise turquoise turquoise turquoise
    EFS turquoise turquoise turquoise turquoise turquoise
    BNC2 turquoise turquoise turquoise turquoise turquoise
    GUCY1A3 turquoise turquoise turquoise turquoise turquoise
    SFRP2 turquoise turquoise turquoise turquoise turquoise
    PXDN turquoise turquoise turquoise turquoise turquoise
    LUM turquoise turquoise turquoise turquoise turquoise
    COL4A2 turquoise turquoise turquoise turquoise turquoise
    RCN3 turquoise turquoise turquoise turquoise turquoise
    LOXL2 turquoise turquoise turquoise turquoise turquoise
    RFTN1 turquoise turquoise turquoise turquoise turquoise
    SERPING1 turquoise gray gray turquoise turquoise
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    HOPX turquoise turquoise turquoise turquoise turquoise
    IGFBP5 turquoise turquoise turquoise turquoise turquoise
    CDH11 turquoise turquoise turquoise turquoise turquoise
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    GLT8D2 turquoise turquoise turquoise turquoise turquoise
    SFRP4 turquoise turquoise turquoise turquoise turquoise
    LAMA4 turquoise turquoise turquoise turquoise turquoise
    SDC2 turquoise turquoise turquoise turquoise turquoise
    CTSK turquoise turquoise turquoise turquoise turquoise
    NNMT turquoise turquoise turquoise turquoise turquoise
    COL10A1 turquoise turquoise turquoise turquoise turquoise
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    ADAM12 turquoise turquoise turquoise turquoise turquoise
    SERPINF1 turquoise turquoise turquoise turquoise turquoise
    TIMP3 turquoise turquoise turquoise turquoise turquoise
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    COL6A2 turquoise turquoise turquoise turquoise turquoise
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    HTRA1 turquoise turquoise turquoise turquoise turquoise
    GUCY1B3 turquoise turquoise turquoise turquoise turquoise
    FIBIN turquoise turquoise turquoise turquoise turquoise
    LHFP turquoise turquoise turquoise turquoise turquoise
    MEIS1 turquoise turquoise turquoise turquoise turquoise
    LAYN turquoise turquoise turquoise turquoise turquoise
    CALD1 turquoise turquoise turquoise turquoise turquoise
    FERMT2 turquoise turquoise turquoise turquoise turquoise
    TNS1 turquoise turquoise turquoise turquoise turquoise
    MYL9 turquoise turquoise turquoise turquoise turquoise
    DDR2 turquoise turquoise turquoise turquoise turquoise
    TAGLN turquoise turquoise turquoise turquoise turquoise
    JAM3 turquoise turquoise turquoise turquoise turquoise
    ACTA2 turquoise turquoise turquoise turquoise turquoise
    MSRB3 turquoise turquoise turquoise turquoise turquoise
    C1S turquoise turquoise turquoise turquoise turquoise
    CCDC80 turquoise turquoise turquoise turquoise turquoise
    MXRA8 turquoise turquoise turquoise turquoise turquoise
    OSMR turquoise turquoise turquoise turquoise turquoise
    MXRA5 turquoise turquoise turquoise turquoise turquoise
    COL6A1 turquoise turquoise turquoise turquoise turquoise
    ISLR turquoise turquoise turquoise turquoise turquoise
    LGALS1 turquoise turquoise turquoise turquoise turquoise
    ADAMTS2 turquoise turquoise turquoise turquoise turquoise
    ANGPTL2 turquoise turquoise turquoise turquoise turquoise
    COL1A1 turquoise turquoise turquoise turquoise turquoise
    OLFML2B turquoise turquoise turquoise turquoise turquoise
    NTM turquoise turquoise turquoise turquoise turquoise
    COL11A1 turquoise turquoise turquoise turquoise turquoise
    FRMD6 turquoise turquoise turquoise turquoise turquoise
    MMP2 turquoise turquoise turquoise turquoise turquoise
    TUBB6 turquoise turquoise turquoise turquoise turquoise
    BGN turquoise turquoise turquoise turquoise turquoise
    MRC2 turquoise turquoise turquoise turquoise turquoise
    SPOCK1 turquoise turquoise turquoise turquoise turquoise
    ADAMTS12 turquoise turquoise turquoise turquoise turquoise
    PCOLCE turquoise turquoise turquoise turquoise turquoise
    COL8A1 turquoise turquoise turquoise turquoise turquoise
    FNDC1 turquoise turquoise turquoise turquoise turquoise
    SULF1 turquoise turquoise turquoise turquoise turquoise
    EFEMP2 turquoise turquoise turquoise turquoise turquoise
    PDGFRB turquoise turquoise turquoise turquoise turquoise
    AEBP1 turquoise turquoise turquoise turquoise turquoise
    THBS2 turquoise turquoise turquoise turquoise turquoise
    THY1 turquoise turquoise turquoise turquoise turquoise
    VIM turquoise turquoise turquoise turquoise turquoise
    VCAN turquoise turquoise turquoise turquoise turquoise
    FSTL1 turquoise turquoise turquoise turquoise turquoise
    COL12A1 turquoise turquoise turquoise turquoise turquoise
    ANTXR1 turquoise turquoise turquoise turquoise turquoise
    COL5A2 turquoise turquoise turquoise turquoise turquoise
    COL5A1 turquoise turquoise turquoise turquoise turquoise
    TIMP2 turquoise turquoise turquoise turquoise turquoise
    COL6A3 turquoise turquoise turquoise turquoise turquoise
    COL3A1 turquoise turquoise turquoise turquoise turquoise
    RAB31 turquoise turquoise turquoise turquoise turquoise
    SPARC turquoise turquoise turquoise turquoise turquoise
    COL1A2 turquoise turquoise turquoise turquoise turquoise
    FBN1 turquoise turquoise turquoise turquoise turquoise
    DCN turquoise turquoise turquoise turquoise turquoise
    GPC6 turquoise turquoise turquoise turquoise turquoise
    VASH2 turquoise turquoise gray turquoise turquoise
    CLDN11 turquoise turquoise turquoise turquoise turquoise
    SMCR8 black gray black gray
    C3orf67 turquoise gray turquoise gray
    NKX2-1 turquoise gray gray gray
    APBA1 turquoise gray gray gray
    TRDV3 turquoise gray turquoise gray
    FOXG1 red gray gray red
    TF turquoise gray gray turquoise
    KCNAB1 turquoise turquoise gray gray
    BAIAP2-AS1 turquoise turquoise gray gray
    SMPDL3B red gray gray red
    FIBCD1 turquoise gray turquoise gray
    HOXA6 turquoise turquoise gray gray
    AKR1C1 turquoise turquoise gray gray
    IL11 turquoise gray gray turquoise
    TMEM184A yellow yellow yellow gray
    NFASC turquoise gray turquoise gray
    TNFRSF10C turquoise gray gray gray
    KCNQ4 turquoise gray turquoise gray
    TFR2 turquoise gray turquoise gray
    • REFERENCES
    • Andre, T., C. Boni, et al. (2009). “Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial.” J Clin Oncol 27(19): 3109-3116.
    • Cersosimo, R. J. (2005). “Oxaliplatin-associated neuropathy: a review.” Ann Pharmacother 39(1): 128-135.
    • De Sousa, E. M. F., X. Wang, et al. (2013). “Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.” Nat Med 19(5): 614-618.
    • Isella, C., A. Terrasi, et al. (2015). “Stromal contribution to the colorectal cancer transcriptome.” Nat Genet 47(4): 312-319.
    • Kuebler, J. P., H. S. Wieand, et al. (2007). “Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07.” J Clin Oncol 25(16): 2198-2204.
    • Marisa, L., A. de Reynies, et al. (2013). “Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value.” PLoS Med 10(5): e1001453.
    • Sadanandam, A., C. A. Lyssiotis, et al. (2013). “A colorectal cancer classification system that associates cellular phenotype and responses to therapy.” Nat Med 19(5): 619-625.
    • Tournigand, C., T. Andre, et al. (2012). “Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial.” J Clin Oncol 30(27): 3353-3360.

Claims (11)

We claim:
1. A method of treating a colon cancer patient comprising:
a) obtaining a colon cancer tumor tissue sample from a patient with colon cancer,
b) contacting a genetic sample from said colon cancer tumor tissue sample with a plurality of specific genetic sequence binding targets and measuring the expression level of a panel consisting essentially of 72 genes, wherein the 72 genes are AKAP12, ANKRD44, BGN, BHLHE41, BMP7, C8orf84, CAB39L, CDKN2B, CKMT2, COL11A1, COMP, CPE, CSGALNACT1, CXCL10, CXCL11, CXCL13, CXCL2, CXCL9, CYP1B1, DAPK1, DCBLD2, DPEP1, EPB41L4B, ERAP2, F5, FAP, FGL2, FN1, FNDC1, GBP1, GBP4, GPX3, GRM8, GZMB, HGD, HOXA13, HSD17B2, ID4, IDO1, IL8, INHBA, MFAP5, MGP, MMP11, MMP28, NFIB, OAS2, PAPPA, PIGR, PLA2G12B, POU2AF1, PRAP1, PROM2, PSMB9, PTPRC, ROBO1, SDC2, SELL, SERPINE1, SFRP2, SGK2, SLC4A4, SPARC, SPP1, SSPN, STC1, TACSTD2, TGFBR3, TM4SF1, TYMS, VCAN, and VNN1,
c) obtaining a gene expression signature for said colon cancer tumor tissue from the gene expression level of the panel of 72 genes in b),
d) responsive to the gene expression signature, identifying said colon cancer tumor tissue as being a subtype responsive to oxaliplatin.
2. The method of claim 1 further comprising the step of administering oxaliplatin in combination with 5′ fluorouracil and leucovorin (FULV) to said patient with colon cancer in a).
3. The method of claim 2, wherein the genetic sample comprises cDNA or RNA either in purified form or as a tissue lysate.
4. The method of claim 2, wherein the identified tumor tissue subtype is of the enterocyte tissue type.
5. A method for treating colon cancer in a patient with Stage II or Stage III colon cancer comprising:
a) obtaining a colon cancer tumor tissue sample from a patient with Stage II or Stage III colon cancer,
b) isolating RNA or producing a lysate from the colon cancer tumor tissue sample,
c) contacting said RNA or said lysate with a plurality of sequence specific probes capable of determining the level of expression of a panel of 72 genes, wherein the panel of 72 genes are AKAP12, ANKRD44, BGN, BHLHE41, BMP7, C8orf84, CAB39L, CDKN2B, CKMT2, COL11A1, COMP, CPE, CSGALNACT1, CXCL10, CXCL11, CXCL13, CXCL2, CXCL9, CYP1B1, DAPK1, DCBLD2, DPEP1, EPB41L4B, ERAP2, F5, FAP, FGL2, FN1, FNDC1, GBP1, GBP4, GPX3, GRM8, GZMB, HGD, HOXA13, HSD17B2, ID4, IDO1, IL8, INHBA, MFAP5, MGP, MMP11, MMP28, NFIB, OAS2, PAPPA, PIGR, PLA2G12B, POU2AF1, PRAP1, PROM2, PSMB9, PTPRC, ROBO1, SDC2, SELL, SERPINE1, SFRP2, SGK2, SLC4A4, SPARC, SPP1, SSPN, STC1, TACSTD2, TGFBR3, TM4SF1, TYMS, VCAN, and VNN1,
d) measuring the gene expression level of the panel of 72 genes and obtaining a gene expression signature for said colon cancer tumor tissue from the gene expression level of said genes in c),
e) responsive to the gene expression signature, identifying said colon cancer tumor tissue as being a subtype responsive to oxaliplatin, and
f) administering oxaliplatin to said patient with Stage II or Stage III colon cancer.
6. The method of claim 5, wherein the oxaliplatin is administered in combination with 5′ fluorouracil and leucovorin (FULV).
7. The method of claim 5, wherein the colon cancer tumor tissue sample is a subtype of the enterocyte tissue type.
8. The method according to claim 1 wherein, if the colon cancer tumor tissue is not identified as being of the subtype not responsive to oxaliplatin, then oxaliplatin is not administered to the patient.
9. The method according to claim 5 wherein, if the colon cancer tumor tissue is not identified as being of the subtype not responsive to oxaliplatin, then oxaliplatin is not administered to the patient.
10. The method of claim 1, wherein said patient is a Stage II colon cancer patient.
11. The method of claim 1, wherein said patient is a Stage III colon cancer patient.
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