[go: up one dir, main page]

US20180168727A1 - Electromagnetic wave therapy device and immunotherapy method thereof - Google Patents

Electromagnetic wave therapy device and immunotherapy method thereof Download PDF

Info

Publication number
US20180168727A1
US20180168727A1 US15/840,242 US201715840242A US2018168727A1 US 20180168727 A1 US20180168727 A1 US 20180168727A1 US 201715840242 A US201715840242 A US 201715840242A US 2018168727 A1 US2018168727 A1 US 2018168727A1
Authority
US
United States
Prior art keywords
millimeter
unit
data
wave
spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US15/840,242
Other languages
English (en)
Inventor
Chih-Min Lin
Ya-Chung Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mr Loop Co Ltd
Original Assignee
Mr Loop Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mr Loop Co Ltd filed Critical Mr Loop Co Ltd
Priority to US15/840,242 priority Critical patent/US20180168727A1/en
Assigned to MR. LOOP CO., LTD. reassignment MR. LOOP CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LIN, CHIH-MIN, YU, YA-CHUNG
Publication of US20180168727A1 publication Critical patent/US20180168727A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves
    • A61N5/022—Apparatus adapted for a specific treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2035—Beam shaping or redirecting; Optical components therefor
    • A61B2018/205547—Controller with specific architecture or programmatic algorithm for directing scan path, spot size or shape, or spot intensity, fluence or irradiance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A61N2005/0627—Dose monitoring systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0632—Constructional aspects of the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N2005/1074—Details of the control system, e.g. user interfaces

Definitions

  • the present invention relates to an electromagnetic wave therapy device and an immunotherapy method thereof. More particularly, the present invention relates to a millimeter-wave therapy device using frequencies between 56 GHz and 65 GHz and capable of providing multi-site usage and an immunotherapy method thereof.
  • Millimeter-wave therapy is mainly through the specific frequency of millimeter-waves and human cells produce resonance phenomenon, so that the human body cells return to normal conditions, in order to achieve the regulation of physiological function, relieve symptoms, improve immunity, treatment and improvement and other effects.
  • millimeter-wave therapy devices can emit only a single fixed millimeter-wave frequency. When there are different frequency needs, only millimeter-wave therapy devices of different frequencies to be purchased in order to meet the requirements for the user.
  • the medical treatment of the millimeter therapy device due to its large size and difficult to carry, patients must be treated under the guidance of medical staffs and can not carry around or use in long distance. Therefore, patients often need to run around, greatly reducing the convenience of millimeter-wave therapy device application.
  • the present invention provides a millimeter-wave therapy device and an immunotherapy method thereof, as solutions to the above problems.
  • the major object of the present invention is to provide a millimeter-wave therapy device which can design and fix a plurality of components of a millimeter-wave therapy device in a millimeter-wave therapy chip and transmit an instruction to provide a millimeter-wave radiation source of 56 GHz to 65 GHz for allowing the patient to carry out millimeter-wave treatment procedures, but also at any time to adjust the millimeter-wave radiation data, to achieve the best therapeutic effect.
  • Another object of the present invention is to provide a millimeter-wave therapy method which can download a corresponding spectrum indication signal from a database according to the disease item to be treated and the patient's temperature and other symptom data, the baseband unit generates therapeutic spectrum contents corresponding to different waveforms, energies, frequencies, pulses, amplitudes and different timetables according to the spectrum indication signals, and generates millimeter-wave radiation sources via the radio frequency unit to not only radiate and treat the skin of the muscles, nerves or internal organs, but also to update the database and improve the treatment effect.
  • Another object of the present invention is to provide a millimeter-wave therapy device which can store the spectrum indication signal in a memory unit in the millimeter-wave therapy device or directly download from the cloud database via the communication device to achieve miniaturization, portable, programmable and low-power millimeter-wave therapy devices.
  • Another object of the present invention is to provide a millimeter-wave therapy device and an immunotherapy method, which can be used in combination with indications for medication to reduce the inflammatory index, reduce the indicator of an oxidative stress, adjust the immunity and reduce the progression of the tumor.
  • the purpose of the human body lesions or abnormal cells returned to normal state, to achieve the regulation of physiological function, soothing symptoms, treatment and improvement and other effects.
  • Another object of the present invention is to provide a millimeter-wave therapy device and an immunotherapy method for providing a relatively simple and convenient treatment for patients who need to go to and from the hospital without having to travel by car and doctors can also adjust the control through a server instruction or monitor the results of millimeter-wave therapy records to control patient's treatment status remotely.
  • an electromagnetic wave therapy device comprising: a control unit providing a first control instruction; a sensing unit, electrically connected to the control unit, for generating a sensing signal; a memory unit, electrically connected to the control unit, for storing at least one data reference table, wherein the data reference table records a spectrum indication signal corresponding to the sensing signal; a baseband unit electrically connected to the control unit for generating a corresponding therapeutic spectrum content according to the spectrum indicating signal; and a radio frequency unit electrically connected to the control unit for emitting a millimeter-wave at a frequency between 56 GHz and 65 GHz and combining with the therapeutic spectrum content to become a millimeter-wave radiation source.
  • the present invention provides an immunotherapy method using the electromagnetic wave therapy device, comprising following steps: confirming or input an indication of information; detecting an ambient temperature or a body temperature of a patient to generate the sensing signal; a control unit reading a sensing signal and indication information and finding a corresponding spectrum indication signal in a data reference table; controlling a baseband unit to generate a therapeutic spectrum content according to a spectrum indication signal; controlling a radio frequency unit to generate a millimeter-wave with a frequency between 56 GHz and 65 GHz and making it a millimeter-wave radiation source in combination with the content of the therapeutic spectrum content; the millimeter-wave radiation source illuminating at least one indication area.
  • control unit the baseband unit, the radio frequency unit and the memory unit are integrated in a single bio-chip to become a millimeter-wave therapeutic chip.
  • the data reference table comprises an indication information, a plurality of cytokines parameters or an oxidative stress index parameter
  • the sensing signal may correspond to the indication information, the plurality of cytokines or the oxidative stress index parameters and there is a corresponding of the spectrum indicating signal.
  • control unit is connected with a second control device
  • the second control device can provide the data reference table, the spectrum indication signal or a second control instruction.
  • a receiving unit connected to the control unit and the second control device, for receiving the second control instruction or the data reference table
  • a transmitting unit connected to the control unit and the second control device, for transmitting the sensing signal or the data reference table to the second control device.
  • an antenna unit electrically connected to the radio frequency unit for focusing and transmitting the millimeter-wave radiation source.
  • a display unit electrically connected to the control unit, for displaying the sensing signal, the data reference table or the spectrum indicating signal; an input interface electrically connected to the control unit; and an expansion unit, electrically connected to the control unit, is a communication device or a data transmission device.
  • the data reference table comprises a timetable of emission parameter data, a waveform parameter data, a frequency parameter data, an energy parameter data, a pulse parameter data, an indication data, a sensing signal data, a plurality of cytokines parameter data, an oxidative stress index parameter, a spectrum indication signal and a combination of the above components.
  • the present invention comprising: transmitting the sensing signal to a second control device; the second control device further finding the corresponding spectrum indication signal from the sensing signal and the indication information; and transmitting the spectrum indication signal or the data reference table to the control unit.
  • the spectrum indication signal or data reference table is stored in the memory unit, and the data reference table comprises: a timetable of emission parameter data, a waveform parameter data, a frequency parameter data, an energy parameter data, a pulse parameter data, an indications data, a sensing signal data, a plurality of cytokine parameter data, an oxidative stress index parameter or spectral indication signal and other data.
  • the millimeter-wave radiation source being radiated with the indication area through the antenna unit comprising:
  • the second control device generating a plurality of spectrum indication signals; transmitting the plurality of spectrum indication signals to the control unit and generating corresponding millimeter-wave illumination sources according to each of the spectrum indication signals; and through the instruction of the second control device, radiating the patient each millimeter-wave radiation source to a corresponding different indication area.
  • the present invention comprising: collecting and analyzing the radiation course record, treatment result, millimeter-wave sample data or sensing signal of the millimeter-wave radiation source, and then adjusting the spectrum indication signal.
  • FIG. 1 is a view of the present invention electromagnetic wave therapy device according to preferred embodiment.
  • FIG. 2A to 2C are diagrams of therapeutic spectrum content and millimeter-wave radiation sources generated by a baseband unit according to various embodiments of the present invention.
  • FIG. 3 is a structural view of another embodiment of the electromagnetic wave therapy device of the present invention.
  • FIG. 4 is a structural view of another embodiment of the millimeter-wave therapy device of the present invention.
  • FIG. 5 is a flowchart of the operation of a preferred embodiment of the electromagnetic wave therapy method of the present invention.
  • FIG. 6 is a flowchart of the operation of the electromagnetic wave treatment method according to still another embodiment of the present invention.
  • FIG. 7 , FIG. 8 and FIG. 9 are the experimental data of the electromagnetic wave therapy method of the present invention respectively after radiation experiment and the control group on the TNF- ⁇ , COX-2, IL-6 results.
  • the millimeter-wave therapy device 10 mainly includes a control unit 11 , a sensing unit 13 , a memory unit 15 , a baseband unit 17 and a radio frequency unit 19 .
  • the control unit 11 , the sensing unit 13 , the memory unit 15 , the baseband unit 17 , and the radio frequency unit 19 may be integrated in a single biochip such as a millimeter-wave therapeutic chip 30 .
  • the control unit 11 is electrically connected to the sensing unit 13 , the memory unit 15 , the baseband unit 17 and the radio frequency unit 19 respectively, and provides a first control instruction 113 .
  • the sensing unit 13 may detect a symptom data such as an ambient temperature and/or a body temperature of a patient and generate a sensing signal 135 accordingly.
  • the memory unit 15 is controlled by the control unit 11 and may store or temporarily store one or more data reference tables 150 .
  • the memory unit 15 may include but is not limited to: indication information (to treat the condition) 151 , a plurality of cytokine parameters 153 , (for example, including but not limited to TNF- ⁇ , IL-4 and IL-8, etc.) and/or parameters of an oxidative stress indicator 157 (e.g.
  • a spectrum indication signal 159 corresponding to each of the sensed signal 135 , the indications 151 , the plurality of cytokine parameters 153 , and/or the oxidation pressure indicator 157 is described.
  • the baseband unit 17 is controlled by the control unit 11 , receives the spectrum indication signal 159 from the memory unit 15 , and generates a therapeutic spectrum content 175 accordingly.
  • the therapeutic spectrum content 175 is composed of a time-domain parameter, a waveform parameter, a frequency parameter, an energy parameter, a pulse parameter, an amplitude parameter and/or a combination of sensing parameters.
  • the plurality of cytokine parameters 153 , an oxidative stress index parameter 157 , and/or different indications 151 may be used to generate corresponding individual waveforms, time domains, frequencies, energies, pulsed and/or amplitude therapeutic spectral content 175 , the fundamental frequency digital phase control signals S 1 , S 2 and S 3 shown in FIGS. 2A-2C .
  • the therapeutic spectrum content 175 generated by the baseband unit 17 is a baseband digital phase control signal S 1 , which can control the time domain phase of the analog electromagnetic wave in the space and the effect of the digital signal state 1 the time t 1 and the action time of the digital signal state 0 are t 2 , and the fundamental frequency digital phase control signal S 1 will generate a relative response to a specific immune cell biological factor.
  • the radio frequency unit 19 is controlled by the control unit 11 to receive the therapeutic spectrum content 175 of the baseband unit 17 and can be used as a carrier of the therapeutic spectrum content 175 to transmit a millimeter-wave radiation source 195 with a frequency of 56 GHz to 65 GHz. 2 A to the millimeter-wave analog signals P1, P2 and P3 shown in FIG. 2C .
  • the millimeter-wave radiation source 195 can radiate various parts of the body (indications area) of a patient or a user 20 for the purpose of being easy to carry and use.
  • the millimeter-wave therapy device 40 of the present invention may also be a module design, which includes a receiving unit 41 and a transmitting unit 43 in addition to the millimeter-wave therapy chip 30 , and is electrically connected the control unit 11 is provided in the millimeter-wave therapy chip 30 .
  • the receiving unit 41 may receive the second control instruction 713 from a second control device 71 .
  • the second control device 71 is disposed outside the millimeter-wave therapy device 40 .
  • the millimeter-wave radiation source 195 can be generated by the radio frequency unit 19 that controls the millimeter-wave therapy device 40 from outside or remotely.
  • the second control device 71 also controls and retrieves a data reference table 150 from an integrated database 75 and temporarily stores the data reference table 150 in the memory unit 15 .
  • the millimeter-wave therapy device 40 may also transmit the data reference table 150 stored in the memory unit 15 to the data reference table 150 stored in the integrated database 75 or updated in the integrated database 75 via the transmission unit 43 .
  • the integrated database 75 is electrically connected to the second control device 71 .
  • the doctor or professional instructor can read the data reference table 150 of the integrated database 75 through the second control device 71 and send it for analysis, the second control instruction 713 controls the millimeter-wave therapy device 40 remotely.
  • the healthcare personnel can also adjust the spectrum indication signal 159 in the data reference table 150 in real time through the second control instruction 713 in response to the improvement or relief of the indication of the use side, and the spectrum indication signal 159 can be controlled, stored or temporarily stored in the integrated database 75 and/or the memory unit 15 .
  • the millimeter-wave therapy device 40 further includes an antenna unit 45 electrically connected to the radio frequency unit 19 .
  • the antenna unit 45 may be allocated inside the millimeter-wave therapy chip 30 or outside the millimeter wave therapy chip 30 , and may be a horn antenna element, a waveguide antenna element, or an array antenna element for transmitting and focusing the millimeter-wave radiation source 195 generated by the radio frequency unit 19 collects the millimeter-wave radiation source 195 into a bundle, and the millimeter wave radiation source 195 can be controlled to radiate a deeper location of the body.
  • the radio frequency unit 19 provides the millimeter-wave radiation source 195 , which will radiate a patient 20 , In particular, the body part of the patient 20 , for example, a knee, a joint, a skin, and the like.
  • the millimeter-wave radiation source 195 can also be used for inducing apoptosis in a tumor, increasing phagocytic activity of macrophages, increasing T cell proliferation and increasing B lymphocyte number, and the present invention is not particularly limited to Single-site treatment.
  • the general millimeter wave system is an extremely high frequency electromagnetic wave with a frequency of 30 GHz to 300 GHz and a wavelength of 1 mm to 10 mm.
  • the present invention uses a millimeter-wave of a frequency of 56 GHz to 65 GHz.
  • the sensing unit 13 senses the ambient temperature at which the device is located and the physiological signal of the patient 2 such as temperature, heartbeat, blood pressure and/or blood lipid concentration, etc. to obtain one or more sensing signal 135 .
  • the sensing signal 135 is controlled by the control unit 11 and stored in the memory unit 15 .
  • the sensing signal 135 generated by the sensing unit 13 may also be transmitted to the second control device 71 via the transmitting unit 43 , and the second control device 71 may further generate the sensing signal 135 based on the sensing signal 135 and/or indication information to the integrated database 75 to find the corresponding data reference table 150 and/or the spectrum indication signal 159 .
  • the second control device 71 further transmits the data reference table 150 and/or the spectrum indication signal 159 to the control unit 11 for temporary storage in the control unit 11 or the storage unit 15 .
  • the control unit 11 sends the first control instruction 113 to control the baseband unit 17 to generate the therapeutic spectrum content 175 and the RF unit 19 to generate the millimeter-wave radiation source 195 .
  • the second control device 71 may be a medical staff or a treatment unit.
  • control unit 11 may also generate a plurality of second control instructions 713 according to the second control command 713 , so that the plurality of second control instructions 713 provide different spectrum indication signals 159 Of the millimeter-wave radiation source 195 so that the patient can perform millimeter-wave therapy procedures in different frequency bands.
  • the “dosage” of the millimeter-wave for treating tumors of the joint or deep tissue may be different and the corresponding radiation times will be different.
  • the second control instruction 713 is transmitted through the control unit 11 , the baseband unit 17 and the radio frequency unit 19 to generate different millimeter-wave radiation sources 195 .
  • the user then moves the millimeter-wave therapy apparatus 40 to the site to be radiated to listen to the instruction from the medical staff or the treatment unit for performing different frequency, waveform, time domain, energy, pulse and/or amplitude millimeter wave irradiation program.
  • the millimeter-wave therapy apparatus 40 of the present invention may further include a display unit 91 and/or an input interface 93 electrically connected to the control unit 11 .
  • the display unit 91 may be used for displaying the sensing signal 135 .
  • the input interface 93 of the further embodiment of the millimeter-wave therapy device 40 according to the present invention may be input for a voice or touch (key) mode for inputting the second control instruction 713 or the data reference table 150 .
  • the millimeter-wave therapy device 40 of the present invention may further include an expansion unit 95 electrically connected to the control unit 11 and may be a communication element (wired or wireless) or a data transmission element (Bluetooth, WIFI, etc.).
  • an expansion unit 95 electrically connected to the control unit 11 and may be a communication element (wired or wireless) or a data transmission element (Bluetooth, WIFI, etc.).
  • the expansion module 95 can also select a power supply unit to provide external power to the millimeter wave therapy apparatus 40 .
  • the millimeter-wave therapy device 40 of the present invention may further include a clipping unit 97 to fix the millimeter wave therapy device 40 .
  • the operation method of using the millimeter-wave therapy device 40 of the present invention includes the following steps: Step S 501 : inputting, confirming the indication data or performing proofreading on the indication data.
  • step S 503 several sensing signal parameters are acquired, for example, temperature, blood pressure, heartbeat or blood lipid concentration.
  • Step S 505 sending a sensing signal to the control unit.
  • Step S 507 finding a data reference table and/or a spectrum indication signal corresponding to indications information and sensing signals, for example, but not limited to, transmitting a time domain parameter data, a waveform parameter data, a frequency parameter data, an energy parameter data, pulse parameter data, amplitude parameter data and/or sensing parameter data.
  • the baseband unit 17 processes the spectrum indication signal 159 and the modulation parameter conversion signal to form a therapeutic spectrum content 175 .
  • the radio frequency unit generates a millimeter-wave radiation source.
  • Step 513 Performing a patient irradiation with a millimeter-wave radiation source to complete a millimeter-wave immunotherapy treatment.
  • the millimeter-wave therapy device of the present invention is a single disease treatment
  • the foregoing step S 501 may also be omitted and not performed.
  • the method for immunotherapy of the present invention comprises the following steps: Step S 601 , inputting, confirming indication information or proofreading the indication information to confirm that the condition to be treated is correct.
  • the sensing unit detects and acquires several sensing signal parameters, such as ambient temperature, or body temperature, blood pressure, heartbeat and/or blood lipid concentration, and the like.
  • Step S 605 the control unit transmits the sensing signal parameter to the second control unit.
  • Step S 607 The second control unit finds at least one spectrum indication signal and/or parameter reference table corresponding to the second control unit, and transmits the parameter reference table and/or the spectrum indication signal to the control unit.
  • Step S 609 The baseband unit is controlled by the control unit, and generates the therapeutic spectrum content according to the spectrum indication unit.
  • the radio frequency unit is controlled by the control unit to generate a millimeter-wave radiation source including the therapeutic spectrum content.
  • step S 613 the millimeter-wave radiation sources are gathered into a bundle by the focusing action of the antenna unit, to increase the body-implantable depth of the millimeter-wave radiation source, for example, a tumor located in a non-surface tissue.
  • step S 615 the millimeter-wave is radiated to the indication area (body location), such as the skin or the joint, according to the location to be treated.
  • Step S 617 The control unit and/or the second control device and the chamber receive the sensing signal to fine-tune the radiation instruction of the millimeter-wave and to process the therapeutic spectrum content or the millimeter-wave radiation source in real time.
  • step S 619 collecting details of the-millimeter wave modulation, the record of the millimeter wave radiation procedure, the condition of use, and the result of the treatment (information after treatment for relieving or ameliorating the symptoms such as the rate of tumor cell proliferation after radiation, etc.) Wave sample data, sensing signal and other data, and under the supervision of medical staff to adjust the spectrum indication signal or parameter reference table, and stored in the memory unit, the second control device or integrated database, the use of such data analysis and statistics, provide millimeter-wave emission modulation instructions for optimal therapy.
  • step S 613 may be omitted.
  • the treatment location is a shallow area such as a skin, and antenna unit is not required.
  • the spectrum indication signal 159 may include millimeter-wave sample data and may be stored in the memory unit 15 .
  • the spectrum indication signal 159 may also be electrically or communicatively connected through the transmitting unit 43 to transmit the spectrum indication signals 159 and/or the data reference table 150 to the integrated database 75 .
  • the collection system of the spectrum indication signal 159 comprises the following data which are given by way of illustration only, and thus are not limitative of the present invention, and which are: timetable of emission parameter data, waveform parameter data, frequency parameter data, energy parameter data, pulse parameter data, indication data, sensing signal data, pressure indicator parameters and/or spectrum indication signals and so on.
  • These spectrum indication signals 159 are stored in the integrated database 75 and can be utilized again for analysis.
  • the timetable of emission parameter data, waveform parameter data, frequency parameter data, energy parameter data and pulse parameters (hereinafter referred to as millimeter-wave comprehensive modulation parameters), for example, the same disease A, at different locations of a body or in the depth of the tissue, the millimeter-wave settings are also slightly different. Because of the different shades of location, the millimeter-wave of the same “dosage” needs to be slightly adjusted for the duration of the radiation. Therefore, data is collected and analyzed through the integrated database 75 . After calculation, send feedback to the millimeter-wave therapy device users or medical staffs.
  • the millimeter-wave therapy device of the present invention and its immunotherapy methods can also be used in combination with chemotherapy medicine.
  • the cancer chemotherapy medicine (such as but not limited to 5-FU, Oxaliplatin and the like) that can be used in combination with the present invention. It is merely administered through transmit millimeter-wave radiation, cancer chemotherapy medicine inhibits tumor cell proliferation, activity and inhibition of oncoprotein performance, the data results performed well comparing with the control group. In addition, cancer chemotherapy with the use of the present invention, significantly improves inhibitory effect of tumor proliferation.
  • FIG. 7 , FIG. 8 and FIG. 9 are shown the experimental data of the electromagnetic wave therapy method of the present invention respectively after radiation experiment and the control group on TNF- ⁇ , IL-2, IL-6, IL-12 ⁇ , IL-1 ⁇ , Rel A and Cox 2.
  • four types of P1, P2, P3 and P4 generated by using the millimeter-wave therapy device ( 10 ) of the present invention are respectively set using P1, P2, P3 and P4 millimeter-wave emission settings and radiate the same kind of immune cell line (for example, but not limited to, macrophages, killer cells or T cells, etc.), that is, human monocytic cell line THP- 1 cells.
  • immune cell line for example, but not limited to, macrophages, killer cells or T cells, etc.
  • THP- 1 cells were cultured in 2 ml of culture solution (3.5 mm petri dish) for 24 hours, induced with PMA (150 nM) for 24 hours, and stimulated with LPS (10 pg/ml) for 4 hours.
  • a plastic pot is filled with about 1 cm depth of water and a stage is placed in the center so that the cell petri dish can be placed thereon.
  • the radio frequency unit ( 19 ) of the millimeter-wave therapy device ( 10 ) needs to be set higher than the cell petri dish 10 cm at this time radio frequency unit ( 19 ) launch coverage area size of about 7 cm radius of the circle, all Petri dishes to be placed within this coverage.
  • TNF- ⁇ tumor necrosis factor
  • COX-2 type II cyclooxygenase
  • IL-6 interleukin-6
  • the results of TNF- ⁇ and IL- 6 expression induced by using P3 and P4 two millimeter wave radiation for 1.5 hours showed that the expression of TNF- ⁇ gene was 6-fold and nearly 9-fold higher than that of the control group respectively IL-6 gene expression than the control group nearly 17 times and 10 times with the significant effect.
  • the millimeter wave of P3 and P4 can achieve the induction of COX-2 at different radiation times.
  • the millimeter wave of P2 at radiation for 2.5 hours can exhibit the effect of inhibiting the expression of COX-2. It is proved that the device of the present invention can generate millimeter waves with different waveforms by using millimeter wave parameters of different COXs.
  • the performance of inducing or inhibiting ⁇ 2 can be achieved.
  • (Macrophages, killer cells, T cells . . . , etc.) cytokines and immune-related factor performance of the purpose, and to control or/and change the body's immune system.
  • mice Male BALB/C mice (20-25 g) were experienced to administer intraperitoneally with LPS (30 ⁇ g/mouse in PBS) administered without millimeter-wave radiation and millimeter-wave radiation for 30 minutes, millimeters-wave radiation for 60 minutes, millimeter-wave radiation for 90 minutes, and millimeter-wave radiation for 150 minutes.
  • the millimeter-wave radiation the first mouse fixed in a plastic chamber, from top to bottom of the whole body radiation, radiation time before the day after the sacrifice of mice and mice obtained blood, isolated from the monocyte (macrophage) and plasma (plasma) for gene and protein performance analysis of mononuclear cells. Plasma was analyzed using a cytokine ELISA kit. It is also possible to show that the body of the animal radiated with the millimeter-wave radiation has a clear and under control or/and a modification of the immunity of the animal body.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US15/840,242 2016-12-16 2017-12-13 Electromagnetic wave therapy device and immunotherapy method thereof Abandoned US20180168727A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/840,242 US20180168727A1 (en) 2016-12-16 2017-12-13 Electromagnetic wave therapy device and immunotherapy method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662435185P 2016-12-16 2016-12-16
US15/840,242 US20180168727A1 (en) 2016-12-16 2017-12-13 Electromagnetic wave therapy device and immunotherapy method thereof

Publications (1)

Publication Number Publication Date
US20180168727A1 true US20180168727A1 (en) 2018-06-21

Family

ID=60491432

Family Applications (1)

Application Number Title Priority Date Filing Date
US15/840,242 Abandoned US20180168727A1 (en) 2016-12-16 2017-12-13 Electromagnetic wave therapy device and immunotherapy method thereof

Country Status (3)

Country Link
US (1) US20180168727A1 (zh)
CN (1) CN107441626A (zh)
TW (1) TWI640291B (zh)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019239160A1 (en) * 2018-06-15 2019-12-19 Emblation Limited Chronotherapeutic treatment profiling
EP3819364A4 (en) * 2018-07-06 2021-07-28 Millitronic Co., Ltd. METHOD AND SYSTEM FOR ACCELERATING THE RATE OF OXIDATION OF FOOD
US20210283414A1 (en) * 2020-03-16 2021-09-16 Emblation Ltd Microwave treatment of skin
TWI747598B (zh) * 2019-11-07 2021-11-21 大陸商中硼（廈門）醫療器械有限公司 射束照射系統及其控制方法
CN114053446A (zh) * 2020-08-03 2022-02-18 湖南纳秒脉冲设备有限公司 纳秒级脉冲电磁波消毒装置及消毒方法
US20220176143A1 (en) * 2020-12-08 2022-06-09 Remedee Labs Module and device for treating symptoms of fibromyalgia using emitting electromagnetic waves
WO2022243702A1 (en) * 2021-05-21 2022-11-24 Emblation Limited Microwave treatment of tissue
EP4419195A4 (en) * 2021-10-22 2025-06-18 NeuroEM Therapeutics, Inc. BRAIN IMMUNE REGULATION THROUGH TRANSCRANIAL ELECTROMAGNETIC TREATMENT

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020258083A1 (zh) * 2019-06-26 2020-12-30 巽晨国际股份有限公司 一种细胞培养方法
CN112569475B (zh) * 2019-09-27 2022-09-02 中国人民解放军军事科学院军事医学研究院 一种电磁波改善阿尔茨海默病空间认知障碍和Aβ沉积的方法
TWI772091B (zh) * 2021-07-05 2022-07-21 邱太一 配合量子能量機使用的穿戴衣物的使用方法
CN113877064B (zh) * 2021-09-29 2024-02-06 南方科技大学 无源射频治疗设备、射频治疗系统及其控制方法和装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110144566A1 (en) * 2007-08-17 2011-06-16 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
US20160256703A1 (en) * 2015-03-04 2016-09-08 Btl Holdings Limited Device and method for contactless skin treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1132638C (zh) * 2000-07-14 2003-12-31 北京东方康威科技发展中心 毫米波治疗仪
CN102179006B (zh) * 2011-04-02 2013-04-03 百慕迪控股有限公司 疗效动态优化的掌上型细胞激励终端及远程治疗系统
US9744074B2 (en) * 2010-12-16 2017-08-29 Scion Neurostim, Llc Combination treatments
US9901398B2 (en) * 2012-06-29 2018-02-27 Covidien Lp Microwave antenna probes
CN103055421B (zh) * 2012-12-26 2015-09-30 中国科学院深圳先进技术研究院 电磁针诊断治疗系统
CN103169450B (zh) * 2013-03-08 2014-12-10 深圳先进技术研究院 THz针移动一体机
US9629749B2 (en) * 2014-02-27 2017-04-25 Iridex Corporation Illuminated treatment probe for delivering laser energy
JP7018313B2 (ja) * 2014-07-24 2022-02-10 シナプスティム リミテッド 生体組織へ刺激を送達するデバイスと方法
AU2016275576B2 (en) * 2015-06-12 2020-08-20 The University Of Sydney Microwave ablation device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110144566A1 (en) * 2007-08-17 2011-06-16 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
US20160256703A1 (en) * 2015-03-04 2016-09-08 Btl Holdings Limited Device and method for contactless skin treatment

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210128932A1 (en) * 2018-06-15 2021-05-06 Emblation Limited Chronotherapeutic treatment profiling
WO2019239160A1 (en) * 2018-06-15 2019-12-19 Emblation Limited Chronotherapeutic treatment profiling
EP3819364A4 (en) * 2018-07-06 2021-07-28 Millitronic Co., Ltd. METHOD AND SYSTEM FOR ACCELERATING THE RATE OF OXIDATION OF FOOD
JP2021528990A (ja) * 2018-07-06 2021-10-28 ミリトロニック カンパニー リミテッドＭｉｌｌｉｔｒｏｎｉｃ Ｃｏ．， Ｌｔｄ． 食品の酸化速度を加速するシステム及び方法
US11987776B2 (en) 2018-07-06 2024-05-21 Millitronic Co., Ltd. Method and system for accelerating food oxidation rate
US11802262B2 (en) 2018-07-06 2023-10-31 Millitronic Co., Ltd. Method and system for accelerating food oxidation rate
TWI813041B (zh) * 2019-11-07 2023-08-21 大陸商中硼（廈門）醫療器械有限公司 射束照射系統及其控制方法
TWI747598B (zh) * 2019-11-07 2021-11-21 大陸商中硼（廈門）醫療器械有限公司 射束照射系統及其控制方法
US12354763B2 (en) 2019-11-07 2025-07-08 Neuboron Therapy System Ltd. Beam irradiation system and control method thereof
US20210283414A1 (en) * 2020-03-16 2021-09-16 Emblation Ltd Microwave treatment of skin
CN114053446A (zh) * 2020-08-03 2022-02-18 湖南纳秒脉冲设备有限公司 纳秒级脉冲电磁波消毒装置及消毒方法
US20220176143A1 (en) * 2020-12-08 2022-06-09 Remedee Labs Module and device for treating symptoms of fibromyalgia using emitting electromagnetic waves
WO2022243702A1 (en) * 2021-05-21 2022-11-24 Emblation Limited Microwave treatment of tissue
EP4419195A4 (en) * 2021-10-22 2025-06-18 NeuroEM Therapeutics, Inc. BRAIN IMMUNE REGULATION THROUGH TRANSCRANIAL ELECTROMAGNETIC TREATMENT

Also Published As

Publication number Publication date
CN107441626A (zh) 2017-12-08
TWI640291B (zh) 2018-11-11
TW201822723A (zh) 2018-07-01

Similar Documents

Publication Publication Date Title
US20180168727A1 (en) Electromagnetic wave therapy device and immunotherapy method thereof
EP3749409B1 (en) Tissue-stimulating device using frequency scanning of electric and magnetic fields
Seo et al. Wireless recording in the peripheral nervous system with ultrasonic neural dust
Zeng Trends in cochlear implants
Borton et al. An implantable wireless neural interface for recording cortical circuit dynamics in moving primates
CN110289700B (zh) 中场耦合器
JP6127142B2 (ja) 個別化治療及び診断のためのｒｆハイパーサーミアデバイス
DK2139557T3 (en) Electronic system for influencing cellular functions in a warm-blooded mammalian subject
Mattsson et al. Is there a biological basis for therapeutic applications of millimetre waves and THz waves?
US20050203578A1 (en) Process and apparatus for treating biological organisms
Li et al. Advancements and challenges in neuromodulation technology: interdisciplinary opportunities and collaborative endeavors
KR102249554B1 (ko) 통합 면역 암치료를 위한 환자 맞춤형 치료 시스템
Chester et al. Laser systems for photobiology and photomedicine
CN101626807B (zh) 用于优化人体组织营养机能的装置
US20220072327A1 (en) Symphonic pulsed electromagnetic field therapy
CN208974988U (zh) 甲状腺部位治疗仪
US8927264B2 (en) Electro medical tool optimization system
Perryman Wireless Neuromodulation: From Bench to Bedside
US11191977B1 (en) Applications of bioactive frequencies and menus thereof
US20250128080A1 (en) Therapeutic device
US20150087009A1 (en) Live cell viability modification system and method
KR101458083B1 (ko) 파동을 이용한 치료장치
Ferrera-Alayón et al. Neoadjuvant Radiochemotherapy Combined with Locoregional Hyperthermia in Locally Advanced Rectal Cancer: Feasibility and Tolerance of Short-Course Versus Long-Course Radiotherapy Schedules
Bhandari et al. Bone stimulators: beyond the black box
Ausra Fully Implantable Wireless and Battery-Free Recording and Neuromodulation Tools for Small Animals

Legal Events

Date Code Title Description
AS Assignment

Owner name: MR. LOOP CO., LTD., TAIWAN

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LIN, CHIH-MIN;YU, YA-CHUNG;REEL/FRAME:044385/0924

Effective date: 20171127

STPP Information on status: patent application and granting procedure in general

Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION

STPP Information on status: patent application and granting procedure in general

Free format text: NON FINAL ACTION MAILED

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION