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US20170304388A1 - New indication of cardiovascular drugs for preparation of cancer inhibition pharmaceutical composition - Google Patents

New indication of cardiovascular drugs for preparation of cancer inhibition pharmaceutical composition Download PDF

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Publication number
US20170304388A1
US20170304388A1 US15/521,536 US201515521536A US2017304388A1 US 20170304388 A1 US20170304388 A1 US 20170304388A1 US 201515521536 A US201515521536 A US 201515521536A US 2017304388 A1 US2017304388 A1 US 2017304388A1
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cancer
hcl
group
agent
hydrochloride
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US15/521,536
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Inventor
Chiu-Hung Chen
Show-Mei CHUANG
Nai-Wan HSIAO
Ruei-Yue Liang
Xiao-Tong Tan
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Launx Biomedical Co Ltd
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Launx Biomedical Co Ltd
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Definitions

  • the present invention provides new clinical indication of cardiovascular drugs, which were approved by FDA. Particularly, the present invention demonstrates that the cardiovascular drugs can effectively inhibit a variety of cancers.
  • Cancer is the most popular disease cause of death in the world.
  • the cancer patients are gradually increase yearly, therefore the treatment method of the cancer has become an important issue.
  • the medical treatments of cancer can be classified as surgical treatment, radiation therapy, chemotherapy and target therapy.
  • the cancer drug is inhibit the cancer cells' duplication and split to prevent the tumor growth and metastasis.
  • the combination of chemotherapies and several targeted therapies were selected; try to eliminate cancer cells more effectively, by means of different mechanisms.
  • the cancer patients happen the drug resistance, that would reduce the effectiveness of the drugs and result in the medical treatment failure.
  • cardiovascular disease aims to prevent or delay the progression of the disease. Also, it aims to reduce the risk of developing cardiovascular diseases. For example, some cardiovascular drugs can treat high blood pressure, and other cardiovascular drugs can promote blood flow in patients with heart failure.
  • the human cancer cells and normal cells often have different characteristics, the differences in patterns or mechanism variation might be seen as a foreign invader.
  • the different cancel cells are located in different locations and the statuses of variations are related to the located environment.
  • the inventors are the first person to propose the use of antibiotic drugs to inhibit the cancer cell growth.
  • the manufacturing of the drug is also a big problem.
  • problems need to overcome, such as drug safety, patient selection, trial dose and other issues.
  • Even the drug has approved by the FDA and sales on the market, there still possibly face the situation of the poor drug response in patients.
  • the cancer patients happen the drug resistance, that would reduce the effectiveness of the drugs and result in the medical treatment failure. Therefore, the new drug development is very difficult.
  • the present invention provides a usage of existing cardiovascular drugs, which have passed clinical trials.
  • the cardiovascular drugs can be classified to ten categories based on the features, includes: peripheral vasodilator reaming enhancer, angiotensin converting agent inhibitor, hypotension and shock therapeutic agent, diuretic, antiarrhythmic agent, antiarralciton drug, antihypertensive agent, anticoagulant and thrombolytic agent, cardiac tonic, intravenous (hemorrhoids) therapeutic agent.
  • Peripheral vasodilator reaming enhancer which can directly or indirectly effect on peripheral blood vessels to increase blood flow, includes: Cilnidipine, Minoxidil, Prazosin HCl, Sildenafil citrate, Tadalafil (Cialis), Nicorandil (Ikorel), Lacidipine (Lacipil, Motens), Benidipine hydrochloride, Cilazapril monohydrate (Inhibace), Fosinopril sodium (Monopril), Almotriptan malate (Axert), Milrinone (Primacor), Avanafil, Lomerizine HCl, Histamine Phosphate, Chromocarb and Pinacidil.
  • Angiotensin converting agent inhibitor which is used to inhibit ACE activity and reduce the production of vasopressin II, so as to reduce the bradykinin hydrolysis, lead to vasodilatation, blood volume, and decrease blood pressure, includes: Benazepril hydrochloride, Losartan potassium, Perindopril Erbumine (Aceon), Irbesartan (Avapro), Candesartan (Atacand), Olmesartan medoxomil (Benicar), Enalaprilat dehydrate, Telmisartan (Micardis), Ramipril (Altace), Valsartan (Diovan), Enalapril maleate (Vasotec), Candesartan cilexetil (Atacand), Conivaptan HCl (Vaprisol), Azilsartan Medoxomil (TAK-491) and Eprosartan Mesylate.
  • Hypotension and shock therapeutic agent which includes: L-Adrenaline (Epinephrine), DL-Adrenaline and Methoxamine HCl.
  • Diuretic which is used to increase the generation of urine and increase the excretion of human body water, includes: Bumetanide, Furosemide (Lasix), Metolazone(Zaroxolyn), Silodosin (Rapaflo), Chlorothiazide, Trichlormethiazide (Achletin), Torsemide (Demadex), Hydrochlorothiazide, Indapamide (Lozol), Dichlorphenamide (Diclofenamide), Amiloride hydrochloride dehydrate, Solifenacin succinate, Methyclothiazide, Benzthiazide, Meticrane, Bendroflumethiazide and Potassium Canrenoate.
  • Antiarrhythmic agent which is used to inhibit abnormal heartbeat rhythm (arrhythmia), such as atrial fibrillation, atrial flutter, and ventricular tachycardia (ventricular tachycardia) and ventricular fibrillation, includes: Adenosine (Adenocard), Dofetilide (Tikosyn), Amiodarone HCl, Ibutilide fumarate, Propafenone (Rytmonorm) and Disopyramide Phosphate.
  • Antiarralciton drug which is used to treat ischemic heart disease symptoms, includes Dexrazoxane Hydrochloride, Ranolazine dihydrochloride, Nisoldipine (Sular), Ranolazine (Ranexa), Acadesine, Nifedipine (Adalat), Amlodipine besylate (Norvasc), Diltiazem HCl (Tiazac), Ticagrelor and Oxprenolol HCl
  • Antihypertensive agent is a medicament for hypertension treatment, which is used to prevent high blood pressure complications, such as stroke and myocardial infarction, includes: Bisoprolol, Doxazosin mesylate, Alfuzosin hydrochloride (Uroxatral), Nebivolol (Bystolic), Reserpine, Methyldopa (Aldomet), Eplerenon, Nimodipine (Nimotop), Betaxolol hydrochloride (Betoptic), Carvedilol, Metoprolol tartrate, Felodipine (Plendil), Amlodipine (Norvasc), Phentolamine mesilate, Imidapril (Tanatril) HCl, Aliskiren hemifumarate, Sodium Nitroprusside, Propranolol HCl, Levobetaxolol HCl, Esmolol HCl, (R)-(+)
  • Anticoagulant is the flag used to prevent blood coagulation (coagulation). Those substances exist in leeches and blood-sucking insects. Anticoagulants can treat thrombotic diseases, include: Prasugrel (Effient), Cilostazol, Nafamostat mesylate, Clopidogrel (Plavix), Apixaban, Aminocaproic acid (Amicar), Dipyridamole (Persantine), Phenindione (Rectadione), Ticlopidine HCl, Ozagrel HCl, Argatroban, Bexarotene, Gabexate mesylate and Ozagrel and Anisindione.
  • Cardiac tonic includes: Pimobendan (Vetmedin), Ampiroxicam, Digoxigenin and Pindolol.
  • Intravenous (hemorrhoids) therapeutic agent includes: Edaravone (MCI-186), Daidzein, Ginkgolide A and Bisacodyl.
  • the cancer is selected from lung cancer, intestinal cancer, colorectal cancer, prostate cancer, liver cancer, bladder cancer, cervical cancer, breast cancer and blood cancer.
  • the effect concentration of the drug in the present invention is 20 mg/kg/day ⁇ 500 mg/kg/day.
  • FIG. 1 illustrates the analysis of cardiovascular drugs for cancer cells inhibition.
  • the present invention provides a usage of cardiovascular drugs for cancer inhibition pharmaceutical composition preparation, which feature is the pharmaceutical composition composed by an effective dosage of cardiovascular drug and a pharmaceutical acceptable salt.
  • the cardiovascular drug of the present invention includes: Lenalidomide Valproic acid sodium salt (Sodium valproate), Decitabine, Bisoprolol, Dexrazoxane Hydrochloride, Prasugrel (Effient), Benazepril hydrochloride, Bumetanide, Cilnidipine, Cilostazol, Doxazosin mesylate, Edaravone (MCI-186), Losartan potassium, Minoxidil, Nafamostat mesylate, Bimatoprost, Alfuzosin hydrochloride (Uroxatral), Clopidogrel (Plavix), Prazosin HCl, Ranolazine dihydrochloride, Sildenafil citrate, Perindopril Erbumine (Aceon), Irbesartan (Avapro), Tadalafil (Cialis), Nebivolol (Bystolic), Pimobendan (Vetmedin), Candesartan (Ata
  • the cancer cells includes lung cancer, gastric cancer, hepatic cancer, colon cancer, skin cancer, cervical cancer, prostate cancer, bladder cancer, breast cancer, leukemia, pancreatic cancer, ovarian cancer, tongue cancer, osteosarcoma, and renal cancer.
  • Cancer cell lines were cultured in different culture medium according to different characteristics (as shown in Table 1). The cell numbers were counted and reseed as 2 ⁇ 10 6 in cell culture plate/flask. Then, the culture medium for culturing the cell lines was added to a volume of 10 ml, and the cells were cultured for 2-3 days. Then, the cells were suspended for loading into 96-well plates. The cell number was 3000 cells and the volume of the culture medium was 100 ul each well.
  • the cardiovascular drugs include peripheral vasodilator reaming enhancer, angiotensin converting agent inhibitor, hypotension and shock therapeutic agent, diuretic, antiarrhythmic agent, antiarralciton drug, antihypertensive agent, anticoagulant thrombolytic agent, cardiac tonic, intravenous (hemorrhoids) therapeutic agent, are used to test the inhibition effect of cancer cell.
  • FIG. 1 the inhibition effects of different cardiovascular drugs on different cancer cells were different (shown as FIG. 1 ).
  • Adiphenine HCl Rivastigmine tartrate (Exelon), Detomidine HCl, Fosinopril sodium (Monopril), Almotriptan malate (Axert), Bexarotene, Gabexate mesylate, Rasagiline mesylate, Imidapril (Tanatril) HCl, Conivaptan HCl (Vaprisol), Ibutilide fumarate, Probucol, Arbidol HCl, S-(+)-Rolipram, Tebipenem pivoxil (L-084), Dichlorphenamide (Diclofenamide), Aliskiren hemifumarate, DL-Carnitine hydrochloride, D-Mannitol (Osmitrol), L-carnitine (Levocarnitine), Amantadine hydrochloride (Symmetrel), Clozapine (Clozaril), Milrinone (Primacor), Mitoxantrone Hydrochlor

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Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1993360T3 (en) 2005-12-28 2017-05-22 Vertex Pharma SOLID FORMS OF N- [2,4-BIS (1,1-DIMETHYLETHYL) -5-HYDROXYPHENYL] -1,4-DIHYDRO-4-OXOQUINOLIN-3-CARBOXAMIDE
US20170304388A1 (en) * 2014-10-24 2017-10-26 Launx Biomedical Co., Ltd. New indication of cardiovascular drugs for preparation of cancer inhibition pharmaceutical composition
AU2015370666B2 (en) 2014-12-22 2020-09-03 Arovella Therapeutics Limited Prevention and treatment of metastatic disease in thrombocytotic cancer patients
WO2017116049A1 (ko) * 2015-12-31 2017-07-06 경북대학교 산학협력단 설폰아마이드계 화합물을 유효성분으로 포함하는 암의 치료 및 전이 억제용 약학적 조성물
EP3241562A1 (en) * 2016-05-02 2017-11-08 Fundació Institut Mar d'Investigacio Medica Zonisamide for use in the treatment of breast cancer
CN106074474A (zh) * 2016-06-15 2016-11-09 中南大学湘雅医院 羟苄丝肼及其在药学上可接受的盐在制备抗肿瘤药物方面的应用
US10688086B2 (en) 2016-10-19 2020-06-23 Germark Biotechnology Co., Ltd Method for treating cancer with dihydropyridine calcium antagonist
CN108066345A (zh) * 2016-11-14 2018-05-25 武汉华杰世纪生物医药有限公司 一种具有抗肿瘤作用的化合物
WO2018115001A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CA3047354A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
US12233073B2 (en) 2017-06-09 2025-02-25 Regents Of The University Of Minnesota Skin care formulations and skin cancer treatment
WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
EP3648764A4 (en) * 2017-07-03 2021-03-31 Menri Group Ltd. TREATMENT OF CANCER WITH DIHYDROPYRIDINES
JP2019064976A (ja) * 2017-10-03 2019-04-25 国立大学法人 熊本大学 抗がん剤
KR101933805B1 (ko) 2017-10-17 2018-12-28 성균관대학교산학협력단 옥셀라딘시트레이트를 유효성분으로 포함하는 뇌암 예방 또는 치료용 약학적 조성물
CN108186652A (zh) * 2017-12-28 2018-06-22 深圳大学 缝隙连接细胞间通迅抑制剂甘珀酸在制备预防和治疗肝细胞癌药物中的应用
LT3746126T (lt) 2018-01-30 2024-10-25 Apnimed, Inc. (Delaware) Miego apnėjos arba paprasto knarkimo gydymui skirti būdai ir kompozicijos
US11931366B2 (en) * 2018-04-19 2024-03-19 Washington University Compositions and methods of use thereof for treatment of proteinopathies
US12329862B2 (en) 2018-06-20 2025-06-17 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
WO2019243452A1 (en) 2018-06-20 2019-12-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
FR3090084B1 (fr) 2018-12-18 2023-10-13 Securengy Projectile pour armes à feu ou air comprimé pour emport liquide ou pulvérulent.
US20220072089A1 (en) * 2018-12-19 2022-03-10 University Of Vermont And State Agricultural College Cancer therapeutic compositions and methods
EP3949959A4 (en) * 2019-04-04 2022-05-11 Daegu-Gyeongbuk Medical Innovation Foundation PHARMACEUTICAL COMPOSITION CONTAINING TRIMEBUTIN OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE SUBSTANCE FOR THE PREVENTION OR TREATMENT OF CANCER
WO2020206078A1 (en) * 2019-04-05 2020-10-08 University Of North Texas Health Science Center At Fort Worth Antidepressants for the treatment or prevention of memory loss and/or cognitive decline or dysfunction in aging
US20220146492A1 (en) * 2019-04-11 2022-05-12 Ian Basil Shine Cell membrane permeability restoring therapy
CN110179803A (zh) * 2019-05-31 2019-08-30 天津科技大学 一种噻吨溴类化合物的应用
WO2021035059A1 (en) * 2019-08-20 2021-02-25 New York University Targeting slc38a2 in pancreatic cancer
EP3797773A1 (en) * 2019-09-03 2021-03-31 Square Power Ltd Rebamipide for use in prophylaxis and treatment of cancer
CN110742890A (zh) * 2019-10-24 2020-02-04 暨南大学 洛美利嗪在制备抗结肠癌药物中的应用
CN110840887A (zh) * 2019-11-18 2020-02-28 杭州彗搏科技有限公司 三氯苯达唑在制备治疗乳腺癌的药物中的应用
CN110876800B (zh) * 2019-11-18 2023-06-27 中南大学 米卡芬净在制备抗肿瘤药物中的应用及抗肿瘤药物
AU2020385714A1 (en) * 2019-11-22 2022-06-09 Leiutis Pharmaceuticals Llp Stable parenteral formulations of Duloxetine
CN111067899B (zh) * 2020-01-08 2021-03-05 温州医科大学 一种抗疟药物磷酸伯氨喹在制备治疗白血病药物上的应用
US11304969B2 (en) * 2020-01-24 2022-04-19 The Florida International Univeristy Board Of Trustees Treatments of prostate cancer
CN111973593A (zh) * 2020-05-09 2020-11-24 深圳市罗湖区人民医院 硝唑尼特及其药学上可接受的盐在制备治疗膀胱癌药物中的用途
CN111557941A (zh) * 2020-06-15 2020-08-21 浙江大学 Plod2的小分子抑制剂米诺地尔在肿瘤治疗中的应用
CN111848717A (zh) * 2020-08-07 2020-10-30 四川大学 靶向调控线粒体能量代谢的化合物及其应用和药物
TW202214245A (zh) * 2020-08-10 2022-04-16 國立彰化師範大學 雙非癌藥物用於製備治療癌症之醫藥組合物的用途
CN112274525B (zh) * 2020-12-04 2022-04-08 遵义医科大学 一种化疗药物组合物及其应用
CN112336725A (zh) * 2020-12-11 2021-02-09 吴照球 甲氧苄啶的医药新用途
CN112569342A (zh) * 2020-12-21 2021-03-30 中南大学 卡泊芬净和/或其可药用盐在制备抗肿瘤药物中的应用及抗肿瘤药物
CN112569215A (zh) * 2020-12-30 2021-03-30 东莞市人民医院 度米芬在制备防治结直肠癌的药物中的应用
EP4108244A1 (en) * 2021-06-25 2022-12-28 Universität Regensburg Ss-lactam antibiotic with significant activity against cancer e.g. colon malignancies
CN113663071B (zh) * 2021-06-28 2022-12-30 四川大学 Fbxl2激活剂在制备治疗egfr驱动的肺癌的药物中的用途
WO2023006954A1 (en) 2021-07-30 2023-02-02 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Asenapine for use in cancer
WO2023035200A1 (zh) * 2021-09-09 2023-03-16 中国福利会国际和平妇幼保健院 五氟利多在制备治疗子宫内膜癌的药物中的应用
CN115887455B (zh) * 2022-08-04 2024-04-05 北京大学人民医院 钙离子通道阻滞剂阿折地平在制备治疗子宫内膜癌的药物中的应用
CN115778957B (zh) * 2022-11-04 2024-06-21 天津中医药大学 千金藤素及包含其的组合物用于预防或治疗酒精性肝病的应用
CN116850266B (zh) * 2023-06-02 2025-05-16 大连医科大学附属第一医院 多粘菌素e甲磺酸钠在制备治疗三阴性乳腺癌药物中的应用
CN116570579A (zh) * 2023-06-13 2023-08-11 深圳市泛谷药业股份有限公司 一种含有阿戈美拉汀和氟伏沙明的药物组合物及其应用
CN117017990A (zh) * 2023-08-28 2023-11-10 温州医科大学 厄达替尼联用度洛西汀或舍曲林在制备治疗肿瘤的药物中的应用
CN116808176B (zh) * 2023-08-30 2023-12-05 上海彗天锦泽生物医学科技有限公司 一种基于免疫检查点阻断的抗肿瘤药物组合物及其应用
US20250213584A1 (en) * 2023-12-27 2025-07-03 Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud Ercc1-xpf complex inhibitor compounds and the use thereof in the treatment of cancer
CN118059099B (zh) * 2024-04-19 2024-06-14 四川大学华西医院 帕罗西汀联合asct2抑制剂用于制备治疗肝癌的药物中的应用及药物组合物
CN119157879A (zh) * 2024-09-24 2024-12-20 中国人民解放军陆军军医大学第一附属医院 YW2301在制备抗Burkitt淋巴瘤的药物中的应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ274678A (en) * 1993-10-01 1999-07-29 Syntex Inc Mycophenolate mofetil or mycophenolic acid in liquid suspension or granules
US5874461A (en) * 1994-12-28 1999-02-23 Janssen Pharmaceutica N.V. Use of Nebivolol as an anti-atherogenic
DK1113797T3 (da) * 1998-09-15 2010-02-01 Lilly Co Eli Anvendelse af duloxetin til behandling af fibromyalgi
US6927223B1 (en) * 2000-05-26 2005-08-09 Washington State University Research Foundation Use of serotonin agents for adjunct therapy in the treatment of cancer
EA013908B1 (ru) * 2000-07-07 2010-08-30 Трастис Оф Тафтс Коллидж Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
IL139975A0 (en) * 2000-11-29 2002-02-10 Univ Ramot Anti proliferative drugs
US20040072824A1 (en) * 2001-06-01 2004-04-15 Adam Telerman Methods and compositions for the treatment of cancer
GB0202337D0 (en) * 2002-02-01 2002-03-20 Univ Birmingham Cancer treatment
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
JP2007505914A (ja) * 2003-09-18 2007-03-15 コンビナトアールエックス インコーポレーティッド 新生物の治療のための薬物の併用方法
EP1684758A4 (en) * 2003-11-06 2009-02-18 Celgene Corp METHODS AND COMPOSITIONS USING THALIDOMIDE FOR THE TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES
JP2007537246A (ja) * 2004-05-12 2007-12-20 バイオランクス カンパニー リミテッド ニコチン酸誘導体を有効成分として含む癌予防及び治療剤
CA2892332C (en) * 2004-05-21 2017-03-21 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
CN1279980C (zh) * 2004-10-14 2006-10-18 孔庆忠 一种抗实体肿瘤药物组合物
JP2006298781A (ja) * 2005-04-15 2006-11-02 Geno Membrane:Kk エストロン３硫酸トランスポーター活性阻害剤
TW200716141A (en) * 2005-05-05 2007-05-01 Combinatorx Inc Compositions and methods for treatment for neoplasms
CN101223149A (zh) * 2005-07-05 2008-07-16 特瓦制药工业有限公司 制备缬沙坦的方法
ES2661169T3 (es) * 2005-07-28 2018-03-27 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Compuestos de monofenol, bencenodiol, o sulfhidrilo para uso en el tratamiento de melanomas
US8148356B2 (en) * 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
WO2007112280A1 (en) * 2006-03-23 2007-10-04 Amgen Inc. Methods and compositions for making and using polymorphs of cinacalcet
CN101099724A (zh) * 2006-07-07 2008-01-09 上海复旦复华药业有限公司 一种微粉化来曲唑及其组合物
CN101103976A (zh) * 2006-07-14 2008-01-16 海南盛科生命科学研究院 一种含阿那曲唑的口服药物组合物及其制备工艺
US20100273868A1 (en) * 2007-01-05 2010-10-28 Cornerstone Therapeutics Inc. R-Zileuton for Use in Conditions Associated with Increased 5-Lipoxygenase and/or Leukotriene Activity (EG Asthma)
CN101730526A (zh) * 2007-03-07 2010-06-09 阿布拉科斯生物科学有限公司 作为抗癌剂的包含雷帕霉素和白蛋白的纳米颗粒
EP2170805B1 (en) * 2007-06-21 2016-03-16 Amgen Inc. Methods of synthesizing cinacalcet and salts thereof
WO2009025854A1 (en) * 2007-08-22 2009-02-26 Burnham Institute For Medical Research Smips: small molecule inhibitors of p27 depletion in cancers and other proliferative diseases
US20120082659A1 (en) * 2007-10-02 2012-04-05 Hartmut Land Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
CN100563645C (zh) * 2007-12-06 2009-12-02 济南帅华医药科技有限公司 一种治疗实体肿瘤的蓓萨罗丁缓释植入剂
WO2009126274A2 (en) * 2008-04-08 2009-10-15 New York University School Of Medicine Methods and compositions for the treatment of cancers, such as melanomas and gliomas
CN101569624A (zh) * 2008-04-29 2009-11-04 石药集团中奇制药技术（石家庄）有限公司 氨氯地平在制备治疗细胞增生性疾病药物中的用途
EP2123626A1 (en) * 2008-05-21 2009-11-25 Laboratorios del Dr. Esteve S.A. Co-crystals of duloxetine and co-crystal formers for the treatment of pain
EP2303255A1 (en) * 2008-06-03 2011-04-06 Université Paris Diderot - Paris 7 Pharmaceutical compositions useful for the treatment of cancers, in particular acute myeloid leukemia and acute promyelocytic leukemia
CN101612400A (zh) * 2009-07-22 2009-12-30 陈志龙 血管紧张素ⅱ的1型受体拮抗剂在抗肿瘤中的应用
CN101690816A (zh) * 2009-08-16 2010-04-07 王丽燕 含钙拮抗剂、aⅱ受体拮抗剂和他汀类药的药物组合物
CN101991553B (zh) * 2009-08-21 2015-02-25 北京以岭生物工程技术有限公司 一种依西美坦片及其制备方法
CN101863806B (zh) * 2010-03-18 2013-02-13 湖北省医药工业研究院有限公司 抗前列腺癌药物(r)-比卡鲁胺的制备方法
WO2011146583A2 (en) * 2010-05-19 2011-11-24 Elan Pharma International Limited Nanoparticulate cinacalcet formulations
WO2012015023A1 (ja) * 2010-07-29 2012-02-02 国立大学法人京都大学 抗がん剤のスクリーニング方法
WO2012079232A1 (zh) * 2010-12-15 2012-06-21 Lai Hung-Cheng 用于治疗癌症的化合物及其应用
CN102631354B (zh) * 2011-02-11 2015-01-21 广东泰禾医药科技有限公司 含维生素d3和二甲双胍的药物组合物
CN102688493B (zh) * 2011-03-25 2014-09-10 鼎泓国际投资（香港）有限公司 含有白藜芦醇及白藜芦醇类衍生物和Bc1-2抑制剂的药物组合物及其应用
CN102813643B (zh) * 2011-06-10 2014-09-24 北京蛋白质组研究中心 bumetanide在抑制肝癌细胞转移中的应用
CN103930132A (zh) * 2011-09-27 2014-07-16 拜奥迈德瓦利探索有限公司 治疗胶质瘤的组合物和方法
CN109985228A (zh) * 2011-11-10 2019-07-09 凯伊药品公司 拟钙剂及其使用方法
ES2384069B1 (es) * 2012-03-29 2013-07-04 Hospital Sant Joan De Déu Cinacalcet y tumores neuroblásticos
CN102600077B (zh) * 2012-03-29 2013-06-05 江苏豪森药业股份有限公司 吉西他滨或其盐纳米乳剂注射液及其制备方法
CN103536607A (zh) * 2012-07-10 2014-01-29 邵金辉 土霉素，普罗帕酮和安乃近的抗肿瘤作用
WO2014018563A2 (en) * 2012-07-23 2014-01-30 The Board Of Trustees Of The Leland Stanford Junior University Methods for the treatment of cancer
US20150224169A1 (en) * 2012-09-06 2015-08-13 Mcmaster University Compounds and methods for selectively targeting cancer stem cells
ES2813340T3 (es) * 2012-09-21 2021-03-23 Intensity Therapeutics Inc Método de tratamiento del cáncer
DK2903616T3 (da) * 2012-10-04 2018-01-29 Ab Science Anvendelse af masitinib i kombination med gemcitabin til behandling af en undergruppe af patienter, der lider af pankreascancer
CN102872066B (zh) * 2012-10-19 2014-07-02 厦门大学 伊维菌素及其衍生物的用途
CA3159085A1 (en) * 2013-01-14 2014-07-17 Clinics Operations Limited Combination cancer therapeutics and uses thereof
CN103933569B (zh) * 2013-01-22 2017-01-11 复旦大学 一种抗肺癌药物组合物及其应用、药盒和包装件
US9890127B2 (en) * 2013-03-11 2018-02-13 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer
US20140271727A1 (en) * 2013-03-18 2014-09-18 National Yang-Ming University Method of using an antidepressant for increasing immunity of a subject and treating cancer
CN104161759B (zh) * 2013-05-16 2019-10-08 中国科学院上海药物研究所 阿那格雷及其衍生物的抗肿瘤用途
CN103396419A (zh) * 2013-08-13 2013-11-20 海宁市绿升医药科技有限公司 肿瘤光动力治疗药二氢卟吩e6-15-乙酯及其制备方法
CN103536925B (zh) * 2013-10-28 2015-07-01 中国医学科学院基础医学研究所 强心苷化合物在非小细胞肺癌治疗中的应用
CN103622975B (zh) * 2013-11-07 2016-06-15 广东药学院 格列吡嗪在制备治疗肿瘤药物中的应用
SG11201607795UA (en) * 2014-04-08 2016-10-28 Methodist Hospital Inos-inhibitory compositions and their use as breast cancer therapeutics
US20170304388A1 (en) * 2014-10-24 2017-10-26 Launx Biomedical Co., Ltd. New indication of cardiovascular drugs for preparation of cancer inhibition pharmaceutical composition

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