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US20140051857A1 - Heterocyclic compounds and thrombopoietin receptor activators - Google Patents

Heterocyclic compounds and thrombopoietin receptor activators Download PDF

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US20140051857A1
US20140051857A1 US14/064,367 US201314064367A US2014051857A1 US 20140051857 A1 US20140051857 A1 US 20140051857A1 US 201314064367 A US201314064367 A US 201314064367A US 2014051857 A1 US2014051857 A1 US 2014051857A1
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substituted
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alkylcarbonyl
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Shingo Owada
Shunsuke Iwamoto
Kazufumi Yanagihara
Katsuaki Miyaji
Takanori Nakamura
Norihisa Ishiwata
Yutaka Hirokawa
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Nissan Chemical Corp
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Nissan Chemical Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Definitions

  • the present invention relates to preventive, therapeutic and improving agents having affinity for and agonistic action on the thrombopoietin receptor for diseases against which activation of the thrombopoietin receptor is effective.
  • it relates to pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or compounds for therapeutic angiogenesis or with anti-arteriosclerosis action that stimulate differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells.
  • Thrombopoietin is a cytokine consisting of 332 amino acids that increases platelet production by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes mediated by its receptor and therefore is promising as a drug for hematological disorders.
  • Recent reports that it stimulates differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells have raised expectations of therapeutic angiogenesis, anti-arteriosclerosis and prevention of cardiovascular events (for example, non-patent document 1, non-patent document 2 and non-patent document 3).
  • Biologically active substances which have been known so far to regulate platelet production through the thrombopoietin receptor include, in addition to thrombopoietin itself, low molecular weight peptides having affinity for the thrombopoietin receptor (for example, patent document 1, patent document 2, patent document 3 and patent document 4).
  • Thrombopoietin and low molecular weight peptides having affinity for the thrombopoietin receptor are likely to be easily degraded in the gastrointestinal tract and are usually difficult to orally administer.
  • thrombopoietin itself the appearance of anti thrombopoietin antibodies have been reported.
  • low molecular weight compounds having excellent affinity for and agonistic action on the thrombopoietin receptor as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective have been demanded.
  • low molecular weight compounds which can serve as platelet increasing agents or increasing agents for other blood cells by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or low molecular weight compounds which can be used for therapeutic angiogenesis or as preventive and therapeutic agents for arteriosclerosis by stimulating endothelial cells and endothelial progenitor cells have been demanded.
  • the present inventors conducted extensive research to find low molecular weight compounds having affinity for and agonistic action on the thrombopoietin receptor, and as a result, found that the compounds of the present invention have high affinity and agonistic action which enable them to show potent platelet increasing action by stimulating differentiation and proliferation of megakaryocytic progenitor cells and megakaryocytes.
  • the present invention was accomplished on the basis of this discovery.
  • the present invention relates to:
  • A is a nitrogen atom or CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl group or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamino
  • B is an oxygen atom, a sulfur atom or NR 9 (wherein R 9 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10
  • R 1 is a C 2-14 aryl group (the C 2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyl group, the C 1-10 alkylcarbonyloxy group and the C 1-10 alkoxycarbonyl group may be optionally substituted with one or more
  • L 1 is a bond, CR 10 R 11 (wherein each of R 10 and R 11 is independently a hydrogen atom or a C 1-6 alkyl group (the C 1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR 12 (wherein R 12 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1
  • X is OR 13 , SR 13 or NR 14 R 15 (wherein R 13 is a hydrogen atom, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxy
  • R 2 is a hydrogen atom, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyloxy group, (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkoxycarbonyl group, the C 1-10 alkylcarbonyloxy group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alky
  • L 2 is a bond, CR 34 R 35 (wherein each of R 34 and R 35 is independently a hydrogen atom or a C 1-6 alkyl group (the C 1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR 16 (wherein R 16 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1
  • L 3 is a bond, CR 17 R 18 (wherein each of R 17 and R 18 is independently a hydrogen atom, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group,
  • L 4 is a bond, CR 20 R 21 (wherein each of R 20 and R 21 is independently a hydrogen atom, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group,
  • Y is an oxygen atom, a sulfur atom or NR 23 (wherein R 23 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group; the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1
  • R 3 is a C 2-14 aryl group (the C 2-14 aryl group may be substituted with one or more substituents independently represented by —W 1 (CW 2 W 3 ) m W 4 (wherein W 1 is (CR 24 R 25 ) n (wherein each of R 24 and R 25 is independently a hydrogen atom or a C 1-6 alkyl group, (the C 1-6 alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR 36 (wherein R 36 is a hydrogen atom, a C 1-6 alkyl group, a formyl group or a C 1-6 alkylcarbonyl group), each of W 2 and W 3 is independently a hydrogen atom or a C 1-3 alkyl group (the C 1-3 alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W 4 is a hydroxyl group, a thi
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamino group
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 , alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamin
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamino group
  • R 9 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group and the
  • L 2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • L 3 is NR 19 (wherein R 19 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group, the C 1-10 alkoxy group, the C 1-10 alkoxy group, the C 1-10 alkoxy group, the C 1-10 alkoxy group, the C 1-10 alkoxy group, the C 1-10
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group,
  • R 3 is a C 2-14 aryl group
  • the C 2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole, group and a C 1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole, group and a C 1-10 alkoxycarbonyl group
  • R 3 is a C 2-14 aryl group (the C 2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamino group and a mono- or di-C 1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • R 3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • R 3 is a C 2-14 aryl group
  • the C 2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamino group and a mono- or di-C 1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a is solvate thereof.
  • hydroxyl group an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, carbamido group, a sulfamido group, a tetrazole group and a C 1-10 alkoxycarbonyl group
  • hydroxyl group an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C 1-10 alkoxycarbonyl group
  • the thrombopoietin receptor activator according to 1. The thrombopoietin receptor activator according to 2. 135.
  • the thrombopoietin receptor activator according to 3. The thrombopoietin receptor activator according to 4. 137.
  • the thrombopoietin receptor activator according to 5. 138.
  • the thrombopoietin receptor activator according to 6. 139.
  • 144. The thrombopoietin receptor activator according to 31 or 32.
  • 145. The thrombopoietin receptor activator according to 33 or 34.
  • 146. The thrombopoietin receptor activator according to 35 or 36.
  • the thrombopoietin receptor activator according to any one of 55 to 60. 151.
  • the thrombopoietin receptor activator according to any one of. 61 to 72.
  • the thrombopoietin receptor activator according to any one of 73 to 84. 153.
  • the thrombopoietin receptor activator according to any one of 85 to 96. 154.
  • the thrombopoietin receptor activator according to any one of 109 to 120.
  • 156. The thrombopoietin receptor activator according to any one of 121 to 132. 157.
  • a preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective which contains the thrombopoietin receptor activator according to any one of 133 to 156, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
  • a platelet increasing agent containing the thrombopoietin receptor activator according to any one of 133 to 156, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
  • Medicament containing the compound according to any one of 1 to 132, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, as an active ingredient.
  • FIG. 1 shows the proliferation of UT7/EPO-mpl cells when stimulated by the compound of the present invention (Synthetic Example 3).
  • FIG. 2 shows the proliferation of UT7/EPO cells when stimulated by the compound of the present invention (Synthetic Example 3).
  • n denotes normal
  • i denotes iso
  • s denotes secondary
  • t denotes tertiary
  • c denotes cyclo
  • o denotes ortho
  • m denotes meta
  • p denotes para
  • Ph denotes phenyl
  • Py denotes pyridyl
  • Ac denotes acetyl
  • Naphthyl denotes naphthyl
  • Me denotes methyl
  • Et denotes ethyl
  • Pr denotes propyl
  • B denotes butyl.
  • halogen atom a fluorine atom, a chlorine atom, a bromine atom or an iodine atom may be mentioned.
  • a C 1-3 alkyl group may be linear, branched or a C 3 cycloalkyl group, and methyl, ethyl, n-propyl, i-propyl and c-propyl and the like may be mentioned.
  • a C 1-6 alkyl group may be linear, branched or a C 3-6 cycloalkyl group, and in addition to those mentioned above, n-butyl, i-butyl, s-butyl, t-butyl, c-butyl, 1-methyl-c-propyl, 2-methyl-c-propyl, n-pentyl, 1-methyl-n-butyl, 2-methyl-n-butyl, 3-methyl-n-butyl, 1,1-dimethyl-n-propyl, 1,2-dimethyl-n-propyl, 2,2-dimethyl-n-propyl, 1-ethyl-n-propyl, c-pentyl, 1-methyl-c-butyl, 2-methyl-c-butyl, 3-methyl-c-butyl, 1,2-dimethyl-c-propyl, 2,3-dimethyl-c-propyl, 1-ethyl-c-propyl, 2-ethyl-c-
  • a C 1-10 alkyl group may be linear, branched or a C 3-10 cycloalkyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentyl, 1-heptyl, 2-heptyl, 1-ethyl-1,2-dimethyl-n-propyl, 1-ethyl-2,2-dimethyl-n-propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl, 6-methyl-2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-1-n-pentyl, 1-nonyl, 2-nonyl, 2,6-dimethyl-4-n-heptyl, 3-ethyl-2,2-dimethyl-3-n-pentyl, 3,5,5-trimethyl-1-n-hexyl, 1-decyl, 2-decyl, 4-decyl, 3,7-dimethyl-1-n
  • C 2-6 alkynyl group ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butyryl, 1,1-dimethyl-2-propynyl, 2-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyny
  • a C 2-6 alkenyl group may be linear, branched or a C 3-6 cycloalkenyl group, and ethenyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, 1-ethylethenyl, 1-methyl-1-propenyl, 1-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-n-propylethenyl, 1-methyl-1-butenyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1,1-
  • a C 2-14 aryl group may be a C 6-14 aryl group containing no hetero atoms as ring constituting atoms or a C 2-9 aromatic heterocyclic group, and a C 2-9 aromatic heterocyclic group may be a 5 to 7-membered C 2-6 heteromonocyclic group or 8 to 10-membered C 5-9 fused heterobicyclic group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
  • a phenyl group As a C 6-14 aryl group containing no hetero atoms, a phenyl group, a 1-indenyl group, a 2-indenyl group, a 3-indenyl group, a 4-indenyl group, a 5-indenyl group, a 6-indenyl group, a 7-indenyl group, an ⁇ -naphthyl group, a ⁇ -naphthyl group, a 1-tetrahydronaphthyl group, 2-tetrahydronaphthyl group, a 5-tetrahydronaphthyl group, a 6-tetrahydronaphthyl group, an o-biphenylyl group, a m-biphenylyl group, a p-biphenylyl group, a 1-anthryl group, a 2-anthryl group, a 9-anthryl group, a 1-phenan
  • a 5 to 7-membered C 2-6 heteromonocyclic group may be a 2-thienyl group, a 3-thienyl group, a 2-furyl group, a 3-furyl group, a 2-pyranyl group, a 3-pyranyl group, a 4-pyranyl group, a 1-pyrrolyl group, a 2-pyrrolyl group, a 3-pyrrolyl group, a 1-imidazolyl group, a 2-imidazolyl group, a 4-imidazolyl group, a 1-pyrazolyl group, a 3-pyrazolyl group, a 4-pyrazolyl group, a 2-thiazolyl group, a 4-thiazolyl group, a 5-thiazolyl group, a 3-isothiazolyl group, a 4-isothiazolyl group, a 5-isothiazolyl group, a 2-oxazolyl group, a 4-oxazolyl group, a 5-oxazolyl group, a 3-
  • a 8 to 10-membered C 5-9 fused heterocyclic group may be a 2-benzofuranyl group, a 3-benzofuranyl group, a 4-benzofuranyl group, a 5-benzofuranyl group, a 6-benzofuranyl group, a 7-benzofuranyl group, a 1-isobenzofuranyl group, a 4-isobenzofuranyl group, a 5-isobenzofuranyl group, a 2-benzothienyl group, a 3-benzothienyl group, a 4-benzothienyl group, a 5-benzothienyl group, a 6-benzothienyl group, a 7-benzothienyl group, a 1-isobenzothienyl group, a 4-isobenzothienyl group, a 5-isobenzothienyl group, a 2-chromenyl group, a 3-chromenyl group, a 4-chromenyl group, a 5-chromeny
  • a C 2-14 aryloxy group may be a C 6-14 aryloxy group containing no hetero atoms as ring constituting atoms or a C 2-9 aromatic heterocyclic oxy group, and a C 2-9 aromatic heterocyclic oxy group may be a 5 to 7-membered C 2-6 heteromonocyclic oxy group or 8 to 10-membered C 5-9 fused heterobicyclic oxy group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
  • a phenyloxy group As a C 6-14 aryloxy group containing no hetero atoms, a phenyloxy group, a 1-indenyloxy group, a 2-indenyloxy group, a 3-indenyloxy group, a 4-indenyloxy group, a 5-indenyloxy group, a 6-indenyloxy group, a 7-indenyloxy group, an ⁇ -naphthyloxy group, a ⁇ -naphthyloxy group, a 1-tetrahydronaphthyloxy group, a 2-tetrahydronaphthyloxy group, a 5-tetrahydronaphthyloxy group, a 6-tetrahydronaphthyloxy group, an o-biphenylyloxy group, a m-biphenylyloxy group, a p-biphenylyloxy group, a 1-anthryloxy group,
  • a 5 to 7-membered C 2-6 heteromonocyclic oxy group may be a 2-thienyloxy group, a 3-thienyloxy group, a 2-furyloxy group, a 3-furyloxy group, a 2-pyranyloxy group, a 3-pyranyloxy group, a 4-pyranyloxy group, a 1-pyrrolyloxy group, a 2-pyrrolyloxy group, a 3-pyrrolyloxy group, a 1-imidazolyloxy group, a 2-imidazolyloxy group, a 4-imidazolyloxy group, a 1-pyrazolyloxy group, a 3-pyrazolyloxy group, a 4-pyrazolyloxy group, a 2-thiazolyloxy group, a 4-thiazolyloxy group, a 5-thiazolyloxy group, a 3-isothiazolyloxy group, a 4-isothiazolyloxy group, a 5-isothiazolyloxy group, a 2-oxazolyloxy
  • a 8 to 10-membered C 5-9 fused heterocyclic oxy group may be a 2-benzofuranyloxy group, a 3-benzofuranyloxy group, a 4-benzofuranyloxy group, a 5-benzofuranyloxy group, a 6-benzofuranyloxy group, a 7-benzofuranyloxy group, a 1-isobenzofuranyloxy group, a 4-isobenzofuranyloxy group, a 5-isobenzofuranyloxy group, a 2-benzothienyloxy group, a 3-benzothienyloxy group, a 4-benzothienyloxy group, a 5-benzothienyloxy group, a 6-benzothienyloxy group, a 7-benzothienyloxy group, a 1-isobenzothienyloxy group, a 4-isobenzothienyloxy group, a 5-isobenzothienyloxy group, a 2-chromenyloxy group, a 3-
  • a C 1-6 alkylcarbonyl group may linear, branched or a C 3-6 cycloalkylcarbonyl group, and be methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, i-propylcarbonyl, c-propylcarbonyl, n-butylcarbonyl, i-butylcarbonyl, s-butylcarbonyl, t-butylcarbonyl, c-butylcarbonyl, 1-methyl-c-propylcarbonyl, 2-methyl-c-propylcarbonyl, n-pentylcarbonyl, 1-methyl-n-butylcarbonyl, 2-methyl-n-butylcarbonyl, 3-methyl-n-butylcarbonyl, 1,1-dimethyl-n-propylcarbonyl, 1,2-dimethyl-n-propylcarbonyl, 2,2-dimethyl-n-propylcarbonyl, 1-ethyl-
  • a C 1-10 alkylcarbonyl may be linear, branched or a C 3-10 cycloalkylcarbonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentylcarbonyl, 1-heptylcarbonyl, 2-heptylcarbonyl, 1-ethyl-1,2-dimethyl-n-propylcarbonyl, 1-ethyl-2,2-dimethyl-n-propylcarbonyl, 1-octylcarbonyl, 3-octylcarbonyl, 4-methyl-3-n-heptylcarbonyl, 6-methyl-2-n-heptylcarbonyl, 2-propyl-1-n-heptylcarbonyl, 2,4,4-trimethyl-1-n-pentylcarbonyl, 1-nonylcarbonyl, 2-nonylcarbonyl, 2,6-dimethyl-4-n-heptylcarbonyl, 3-ethyl-2,2-dimethyl-3-n-
  • a C 1-10 alkoxy group may be linear, branched or a C 3-10 cycloalkoxy group, and methoxy, ethoxy, n-propoxy, i-propoxy, c-propoxy, n-butoxy, i-butoxy, s-butoxy, t-butoxy, c-butoxy, 1-methyl-c-propoxy, 2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c-pentyloxy, 1-methyl-c-butoxy, 2-methyl-c-butoxy, 3-methyl-c-butoxy, 1,2-dimethyl-c-propoxy, 2,3-dimethyl-c-propoxy, 1-ethyl-c-propoxy, 2-ethyl-
  • a C 1-6 alkoxycarbonyl group may be linear, branched or a C 3-6 cycloalkoxycarbonyl group, and methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, c-propylcarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, s-butoxycarbonyl, t-butoxycarbonyl, c-butoxycarbonyl, 1-methyl-c-propoxycarbonyl, 2-methyl-c-propoxycarbonyl, n-pentyloxycarbonyl, 1-methyl-n-butoxycarbonyl, 2-methyl-n-butoxycarbonyl, 3-methyl-n-butoxycarbonyl, 1,1-dimethyl-n-propoxycarbonyl, 1,2-dimethyl-n-propoxycarbonyl, 2,2-dimethyl-n-propoxycarbonyl, 1-ethyl-n-propoxycarbonyl, c-penty
  • a C 1-10 alkylcarbonyloxy group may be linear, branched or a C 3-10 cycloalkylcarbonyloxy group, and methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, i-propylcarbonyloxy, c-propylcarbonyloxy, n-butylcarbonyloxy, i-butylcarbonyloxy, s-butylcarbonyloxy, t-butylcarbonyloxy, c-butylcarbonyloxy, 1-methyl-c-propylcarbonyloxy, methyl-c-propylcarbonyloxy, n-pentylcarbonyloxy, 1-methyl-n-butylcarbonyloxy, 2-methyl-n-butylcarbonyloxy, 3-methyl-n-butylcarbonyloxy, 1,1-dimethyl-n-propylcarbonyloxy, 1,2-dimethyl-n-propylcarbonyloxy, 2,
  • a C 1-10 alkylcarbonylamino group may be linear, branched or a C 3-10 cycloalkylcarbonylamino group, and methylcarbonylamino, ethylcarbonylamino, n-propylcarbonylamino, i-propylcarbonylamino, c-propylcarbonylamino, n-butylcarbonylamino, butylcarbonylamino, s-butylcarbonylamino, t-butylcarbonylamino, c-butylcarbonylamino, 1-methyl-c-propylcarbonylamino, 2-methyl-c-propylcarbonylamino, n-pentylcarbonylamino, 1-methyl-n-butylcarbonylamino, 2-methyl-n-butylcarbonylamino, 3-methyl-n-butylcarbonylamino, 1,1-dimethyl-n-propylcarbonylamino, 1,
  • a C 1-10 monoalkylamino group may be linear, branched or a C 3-10 cycloalkylamino group, and methylamino, ethylamino, n-propylamino, i-propylamino, c-propylamino, n-butylamino, i-butylamino, s-butylamino, t-butylamino, c-butylamino, 1-methyl-c-propylamino, 2-methyl-c-propylamino, n-pentylamino, 1-methyl-n-butylamino, 2-methyl-n-butylamino, 3-methyl-n-butylamino, 1,1-dimethyl-n-propylamino, 1,2-dimethyl-n-propylamino, 2,2-dimethyl-n-propylamino, 1-ethyl-n-propylamino, c-pentylamino, 1-
  • An asymmetric C 1-10 dialkylamino group may be linear, branched or a C 3-10 cycloalkylamino group, and (methyl, ethyl)amino, (methyl, n-propyl)amino, (methyl, i-propyl)amino, (methyl, c-propyl)amino, (methyl, n-butyl)amino, (methyl, i-butyl)amino, (methyl, s-butyl)amino, (methyl, t-butyl)amino, (methyl, n-pentyl)amino, (methyl, c-pentyl)amino, (methyl, n-hexyl)amino, (methyl, c-hexyl)amino, (ethyl, n-propyl)amino, (ethyl, 1-propyl)amino, (ethyl, c-propyl)a
  • the protecting group in a protected hydroxyl group may be a C 1-4 alkoxymethyl group (such as MOM: methoxymethyl, MEM: 2-methoxyethoxymethyl, ethoxymethyl, n-propoxymethyl, i-propoxymethyl, n-butoxymethyl, iBM: isobutyloxymethyl, BUM: t-butoxymethyl, POM: pivaloyloxymethyl, SEM: trimethylsilylethoxymethyl and the like, preferably a C 1-2 alkoxymethyl or the like), an aryloxymethyl (such as BOM: benzyloxymethyl, PMBM: p-methoxybenzyloxymethyl, p-AOM: p-anisyloxymethyl and the like, preferably benzyloxymethyl or the like), a C 1-4 alkylaminomethyl group (such as dimethylaminomethyl), a substituted acetamidomethyl group (such as Acm: acetamidomethyl, Tacm: tri
  • substituent R 1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-
  • Substituents a C 1-10 alkyl group, a halogen atom, a alkyl group substituted with one or more halogen atoms, a nitro group, an amino group, an amino group substituted with one or two C 1-10 alkyl groups, an amino group substituted with a C 1-10 alkylcarbonyl group, a thiol group substituted with a C 1-10 alkyl group, a thiol group substituted with a C 1-10 alkylcarbonyl group, hydroxyl group, a C 1-6 alkoxy group, a C 1-10 alkoxy group substituted with one or more halogen atoms, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group and a C 1-10 alkylcarbonyl group.
  • substituent R 1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7
  • Substituents a methyl group, a t-butyl group, a trifluoromethyl group, a trifluoromethoxy group, a bromine atom, a chlorine atom, a fluorine atom, a methoxy group, a methylamino group, a dimethylamino group, a t-butyloxy group and a t-butylamino group.
  • substituents are a 3-methyl-phenyl group, a 4-methyl-phenyl group, a 3,4-dimethyl-phenyl group, a 3-t-butyl-phenyl group, a 4-t-butyl-phenyl group, a 3-trifluoromethyl-phenyl group, a 4-trifluoromethyl-phenyl group, a 4-trifluoromethoxy-phenyl group, a 4-bromo-phenyl group, a 3,4-ditrifluoromethyl-phenyl group, a 3-chloro-phenyl group, a 4-chloro-phenyl group, a 3-fluoro-phenyl group, a 4-fluoro-phenyl group, a 3,4-dichloro-phenyl group, 3,4-difluoro-phenyl group, a 4-methoxy-phenyl group, a 4-methylamino-phenyl group, a 4-methyl-2-thien
  • L 1 are a bond, CH 2 , a oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe 2 , N—CH 2 Ph and the like, and particularly preferable examples are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, NMe and the like.
  • substituent R 2 are a hydrogen atom, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t-butyl group, and a phenyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the t-butyl group and the phenyl group may be optionally substituted with an amino group, a monomethylamino group, a dimethylamino group, a monoethylamino group, a diethylamino group, a methoxy group, an ethoxy group, a methoxycarbonyl group, an ethoxycarbonyl group, a methylcarbonyloxy group, an ethylcarbonyloxy group, a methylcarbonylamino group or an ethylcarbonylamino group and the like), and particularly preferable examples are a hydrogen atom,
  • L 2 are a bond, CH 2 , oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe 2 , N—CH 2 Ph and the like, and particularly preferable examples are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, NMe and the like.
  • L 3 are a bond, CH 2 , an oxygen atom, a sulfur atom, NE, NH—OH, N-Me, N—CHO, CHMe, CMe 2 , N—CH 2 PH and the like, and particularly preferred examples are a bond, CH 2 , an oxygen atom, sulfur atom, NH, NMe and the like.
  • substituent R 3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7
  • Substituents a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a hydroxycarbamido group, a cyanocarbamido group, a sulfamido group, a hydroxysulfamido group, a cyanosulfamido group, a tetrazole group, —CH 2 CO 2 H, —OCH 2 CO 2 H, —NHCH 2 CO 2 H, —CH 2 CH 2 CO 2 H, an alkoxycarbonyl group and the following heterocyclic groups substituted with a hydroxyl group.
  • Heterocyclic groups a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group and a 1,2-thiazole group.
  • substituent R 3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a
  • Substituent set A a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid, a carbamido group, a hydroxycarbamido group, a cyanocarbamido group, a sulfamido group, hydroxysulfamido group, a cyanosulfamido group, a tetrazole group, —CH 2 CO 2 H, —OCH 2 CO 2 H, —NHCH 2 CO 2 H, —CH 2 CH 2 CO 2 H and an alkoxycarbonyl group.
  • Substituent set B an amino group, a nitro group, cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorines, a sulfamido group substituted with one or more C 1-10 alkyl groups, carbamido group substituted with one or more C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group.
  • substituent R 3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a.
  • Substituents a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group, —CH 2 CO 2 H, —OCH 2 CO 2 H, —NHCH 2 CO 2 H and —CH 2 CH 2 CO 2 H.
  • substituent R 3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 6-isoquinolyl
  • Substituent set A a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group, —CH 2 CO 2 H, —OCH 2 CO 2 H, —NHCH 2 CO 2 H and —CH 2 CH 2 CO 2 H.
  • Substituent set B an amino group, a nitro group, cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C 1-10 alkyl groups, carbamido group substituted with one or more C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group.
  • L 4 are a bond, CH 2 , an oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe 2 , N—CH 2 Ph and the like, and particularly preferred examples are a single bond, CH 2 , an oxygen atom, a sulfur atom, NH, NMe and the like.
  • X are OH, SH, NH 2 , OMe, SMe, NHMe, NHEt, NH—CHO, NH—CH 2 Ph, OCH 2 Ph, SCH 2 Ph, OC( ⁇ O)CH 3 , SC( ⁇ O)CH 3 , NC( ⁇ O)CH 3 and the like, and particularly preferred examples are OH, SH, NH 2 and the like
  • Y are an oxygen atom, a sulfur atom, NH, N—OH, N—CHO, N-Me, N—CH 2 Ph, N-OMe, N—OCH 2 Ph an the like, and particularly preferred examples are an oxygen atom, a sulfur atom, NH, N—OH and the like.
  • thrombopoietin receptor activator the preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective and the platelet increasing agent of the present invention are as follows.
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamin
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbonylamin
  • A is CR 4 (wherein R 4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkylcarbony
  • A is CR 37 (wherein R 37 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C 2-6 alkenyl or a C 2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C 2-6 alkenyl groups or one or two C 2-6 alkynyl groups), formyl group, a halogen atom, a nitro group, a cyano group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkylcarbonyloxy group, a C
  • L 3 is NR 19 (wherein R 19 is a hydrogen atom, hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a, C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group, the C 1-10 alkoxy group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a
  • L 4 is NR 22 (wherein R 22 is a hydrogen atom, a hydroxyl group, a formyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group, the C 1-10 alkoxycarbonyl group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom,
  • R 2 is a hydrogen atom, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the is C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyloxy group and the C 1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbon
  • R 2 is a hydrogen atom, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-3 alkoxy group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group and the C 1-3 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group, a protected hydroxyl
  • R 2 is a hydrogen atom, a C 1-10 alkyl group, a C 2-6 alkenyl group or a C 2-6 alkynyl group (the C 1-10 alkyl group, the C 2-6 alkenyl group and the C 2-6 alkynyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds
  • R 2 is a hydrogen atom or a C 1-6 alkyl group (the C 1-6 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkoxy group, a C
  • R 2 is a hydrogen atom or a C 1-3 alkyl group
  • the C 1-3 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkylcarbonyloxy group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonylamino group, an amino group, a mono- or di-C 1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 1 is a C 2-14 aryl group
  • the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyloxy group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, C 1-10 alkoxy group and the C 1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxy
  • R 1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group; a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkyl
  • R 1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkyl
  • R 1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyloxy group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyl group, the C 1-10 alkoxycarbonyl group and the C 1-10 alky
  • R 1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 1-10 alkoxy group, a C 1-10 alkylcarbonyl group, a C 1-10 alkoxycarbonyl group, a C 1-10 alkylcarbonyloxy group (the C 1-10 alkyl group, the C 2-6 alkenyl group, the C 2-6 alkynyl group, the C 1-10 alkoxy group, the C 1-10 alkylcarbonyl group, the C 1-10 alkoxycarbonyl group and the C 1-10 alky
  • R 3 is a C 2-14 aryl group
  • the C 2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C 1-10 alkyl groups, a carbamido group substituted with one or more C 1-10 alkyl groups, a C 1-10 alkoxycarbonyl group, a C 1-10 alkoxy group, a
  • R 3 is a phenyl group, a thienyl, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a
  • R 3 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C 1-10 alkyl groups, a carbamido group substituted with one or more C 1-10 alkyl groups, a C 1-10 alkoxycarbonyl group, a C 1-10 alkoxy group, a C 1-10 al
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C 1-10
  • R 3 is a phenyl group (the phenyl group is optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group (the phenyl group is optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a carboxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a sulfonic acid group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group, a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group, a 1,2-thiazole group, a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the 1,3,4-oxadiazole group, the 1,3,4-thiadiazole group, the 1,2,4-oxadiazole group, the 1,2,4-thiadia
  • R 3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the quinolyl group and the isoquinolyl group are optionally substituted with an azole group optionally substituted with one or more hydroxyl groups
  • the azole group is a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group or a 1,2-thiazole
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more —CH 2 CO 2 H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group substituted with one or more —CH 2 CO 2 H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group, (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —OCH 2 CO 2 H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —NHCH 2 CO 2 H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —CH 2 CH 2 CO 2 H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group substituted with one or more —CH 2 CH 2 CO 2 H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group (the phenyl group is optionally substituted with one or more substituents optionally selected from the group consisting of:
  • a carboxyl group a phosphonic acid group, sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group and a tetrazole group
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of:
  • R 3 is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of:
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a carboxyl group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group), t
  • R 3 is a phenyl group substituted with a carboxyl group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a sulfonic acid group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbon
  • R 3 is a phenyl group substituted with a sulfonic acid group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group; a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more hydroxyl groups and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a —CH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido is group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkyl
  • R 3 is a phenyl group substituted with a —CH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —OCH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbon
  • R 3 is a phenyl group substituted with a —OCH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —NHCH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbony
  • R 3 is a phenyl group substituted with a —NHCH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • R 3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group
  • the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —CH 2 CH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbony
  • R 3 is a phenyl group substituted with a —CH 2 CH 2 CO 2 H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C 1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C 1-10 alkyl groups, a carbamido group substituted with one or two C 1-10 alkyl groups and a C 1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • thrombopoietin receptor activators represented by any of 1) to 86).
  • thrombopoietin receptor activators represented by 87) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.
  • Platelet increasing agents containing the thrombopoietin receptor activators represented by 87) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.
  • the compounds of the present invention represented by the formula (1) may be present in the form of tautomers or geometrical isomers which undergo endocyclic or exocyclic isomerization, mixtures of tautomers or geometric isomers or mixtures of thereof.
  • the compounds of the present invention may be in the form of resolved optical isomers or in the form of mixtures containing them in certain ratios.
  • furan compounds, thiophene compounds and pyrrole compounds of the present invention may be present in the form of tetronic acid (4-hydroxy-2(5H)-furanone) analogues, thiotetronic acid (4-hydroxy-2(5H)-thiophenone) analogues and tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogues as shown below by the formulae (2), (3) and (4), mixtures thereof or mixtures of isomers thereof.
  • the compounds of the present invention represented by the formula (1) or pharmaceutically acceptable salts thereof may be in the form of arbitrary crystals or arbitrary hydrates, depending on the production conditions.
  • the present invention covers these crystals, hydrates and mixtures. They may be in the form of solvates with organic solvents such as acetone, ethanol and tetrahydrofuran, and the present invention covers any of these forms.
  • the compounds of the present invention represented by the formula (1) may be converted to pharmaceutically acceptable salts or may be liberated from the resulting salts, if necessary.
  • the pharmaceutically acceptable salts of the present invention may be, for example, salts with alkali metals (such as lithium, sodium and potassium), alkaline earth metals (such as magnesium and calcium), ammonium, organic bases and amino acids. They may be salts with inorganic acids (such as hydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid) and organic acids (such as acetic acid, citric acid, maleic acid, fumaric acid, benzenesulfonic acid and p-toluenesulfonic acid).
  • the compounds which serve as prodrugs are derivatives of the present invention having chemically or metabolically degradable groups which give pharmacologically active compounds of the present invention upon solvolysis or under physiological conditions in vivo. Methods for selecting or producing appropriate prodrugs are disclosed, for example, in Design of Prodrug (Elsevier, Amsterdam 1985).
  • acyloxy derivatives obtained by reacting the compound with appropriate acyl halides or appropriate acid anhydrides may, for example, be mentioned as prodrugs.
  • Acyloxys particularly preferred as prodrugs include —OCOC 2 H 5 , —OCO(t-Eu), —OCOC 15 H 31 , —OCO(m-CO 2 Na-Ph), —OCOCH 2 CH 2 CO 2 Na, —OCOCH(NH 2 )CH 3 , —OCOCH 2 N(CH 3 ) 2 and the like.
  • amide derivatives obtained by reacting the compound having an amino group with appropriate acid halides or appropriate mixed acid anhydrides may, for example, be mentioned as prodrugs.
  • Amides particularly preferred as prodrugs include —NHCO(CH 2 ) 20 OCH 3 , —NHCOCH(NH 2 )CH 3 and the like.
  • carboxylic acid esters with aliphatic alcohols or carboxylic acid esters obtained by the reaction with an alcoholic free hydroxyl group of 1,2- or 1,3-digylcerides may, for example, be mentioned as prodrugs.
  • Particularly preferred prodrugs are methyl esters and ethyl esters.
  • the preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective or platelet increasing agents which contain the thrombopoietin receptor activators of the present invention, tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof as an active ingredient may usually be administered as oral medicines such as tablets, capsules, powder, granules, pills and syrup, as rectal medicines, percutaneous medicines or injections.
  • the agents of the present invention may be administered as a single therapeutic agent or as a mixture with other therapeutic agents. Though they may be administered as they are, they are usually administered in the form of medical compositions. These pharmaceutical preparations can be obtained by adding pharmacologically and pharmaceutically acceptable additives by conventional methods.
  • Oral liquid preparations may be in the form of aqueous or oily suspensions, solutions, emulsions, syrups or elixirs or may be supplied as dry syrups to be mixed with water or other appropriate solvents before use.
  • Such liquid preparations may contain ordinary additives such as suspending agents, perfumes, diluents and emulsifiers. In the case of rectal administration, they may be administered as suppositories.
  • Suppositories may use an appropriate substance such as cacao butter, laurin tallow, Macrogol, glycerogelatin, Witepsol, sodium stearate and mixtures thereof as the base and may, if necessary, contain an emulsifier, a suspending agent, a preservative and the like.
  • pharmaceutical ingredients such as distilled water for injection, physiological saline, 5% glucose solution, propylene glycol and other solvents or solubilizing agents, a pH regulator, an isotonizing agent and a stabilizer may be used to form aqueous dosage forms or dosage forms which need dissolution before use.
  • the dose of the agents of the present invention for administration to human is usually about from 0.1 to 1000 mg/human/day in the case of oral drugs or rectal administration and about from 0.05 mg to 500 mg/human/day in the case of injections, though it depends on the age and conditions of the patient.
  • the above-mentioned ranges are mere examples, and the dose should be determined from the conditions of the patient.
  • the present invention is used when the use of compounds which have thrombopoietin receptor affinity and act as thrombopoietin receptor agonists are expected to improve pathological conditions.
  • hematological disorders accompanied by abnormal platelet count may be mentioned.
  • it is effective for therapy or prevention of human and mammalian diseases caused by abnormal megakaryopoiesis, especially those accompanied by thrombocytopenia.
  • diseases include thrombocytopenia accompanying chemotherapy or radiotherapy of cancer, thrombocytopenia accompanying antiviral therapy for diseases such as hepatitis C, thrombocytopenia caused by bone marrow transplantation, surgery and serious infections, or gastrointestinal bleeding, but such diseases are not restricted to those mentioned.
  • Typical thrombocytopenias such as aplastic anemia, idiopathic thrombocytopenic purpura, myelodysplastic syndrome, hepatic disease, HIV infection and thrombopoietin deficiency are also targets of the agents of the present invention.
  • the present invention may be used as a peripheral stem cell mobilizer, a megakaryoblastic or megakaryocytic leukemia cell differentiation inducer and a platelet increasing agent for platelet donors.
  • potential applications include therapeutic angiogenesis based on differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, prevention and therapy of arteriosclerosis, myocardial infarction, unstable angina, peripheral artery occlusive disease, but there is no restriction.
  • the compounds represented by the formula (1) are prepared by the process represented by the formula (5) illustrated below.
  • the reaction of the compound (I) with a —NH 2 compound (II) in a solvent, if necessary in the presence of a catalyst, under heating with stirring gives a desired compound or its precursor.
  • the precursor may be, if necessary, hydrolyzed, deprotected, reduced or oxidized to a desired compound.
  • the compounds of the present invention usually can be purified by column chromatography, thin layer chromatography, high performance liquid chromatography (HPLC) or high performance liquid chromatography-mass spectrometry (LC-MS) and, if necessary, they may be obtained with high purity by recrystallization or washing with solvents.
  • Triethylamine (0.28 mL, 2.0 mmol) was added dropwise, and the reaction solution was stirred for another 20 minutes under cooling with ice. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with chloroform, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated to give the desired product as a brown oil (58 mg, yield 68%).
  • reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a reddish brown oil (0.12 g, yield 68%).
  • Acetic anhydride (1.89 mL, 20 mmol) was added to a suspension of 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) in acetic acid (10 mL), and the mixture was heated with reflux for 6 hours. After cooling, the precipitated solid was filtered to obtain 2.12 g of the desired product as a colorless solid (yield 89%).
  • Methyl iodide (1.49 mL, 24 mmol) was added to a suspension of 4-bromo-2-fluorobenzoic acid (4.38 g, 20 mmol) and sodium carbonate (6.36 g, 60 mmol) in dimethylformamide (50 mL), and the mixture was stirred overnight at room temperature. After completion of the reaction, ethyl acetate was added, and the mixture was washed with water and a saturated ammonium chloride aqueous solution. After drying over magnesium sulfate, concentration was carried out to obtain 4.50 g of the desired product as a colorless solid (yield 97%).
  • Table 15 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the reference synthetic example (R.S.E.) 33, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • Table 16 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the reference synthetic example (R.S.E.) 67, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).

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Abstract

A compound represented by the formula (1):
Figure US20140051857A1-20140220-C00001
wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14 aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

Description

  • This application is a continuation in part of PCT/JP2004/008165 filed on Jun. 4, 2004, and incorporated entirely herein by reference.
    • TECHNICAL FIELD
  • The present invention relates to preventive, therapeutic and improving agents having affinity for and agonistic action on the thrombopoietin receptor for diseases against which activation of the thrombopoietin receptor is effective. Specifically, it relates to pharmaceutical compositions comprising compounds which increase platelets through stimulation of differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or compounds for therapeutic angiogenesis or with anti-arteriosclerosis action that stimulate differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells.
    • BACKGROUND ART
  • Thrombopoietin is a cytokine consisting of 332 amino acids that increases platelet production by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes mediated by its receptor and therefore is promising as a drug for hematological disorders. Recent reports that it stimulates differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells have raised expectations of therapeutic angiogenesis, anti-arteriosclerosis and prevention of cardiovascular events (for example, non-patent document 1, non-patent document 2 and non-patent document 3).
  • Biologically active substances which have been known so far to regulate platelet production through the thrombopoietin receptor include, in addition to thrombopoietin itself, low molecular weight peptides having affinity for the thrombopoietin receptor (for example, patent document 1, patent document 2, patent document 3 and patent document 4).
  • As a result of search for nonpeptidic low molecular weight compounds that increase platelet production mediated by the thrombopoietin receptor, low molecular weight compounds having affinity for the thrombopoietin receptor have been reported (for example, patent document 5 to patent document 24).
    • 1) Applications filed by Hokuriku Seiyaku Co., Ltd. relating to 1,4-benzodiazepine derivatives (patent documents 5 and 6)
    • 2) International Laid-open Patent Applications filed by Shionogi & Co., Ltd. (patent documents 7-10)
    • 3) International Laid-open Patent Applications filed by SmithKline Beecham Corp (patent documents 11-19)
    • 4) Japanese Laid-open Patent Application filed by Torii Pharmaceutical Co., Ltd. (patent document 20)
    • 5) International Laid-open Patent Application filed by Roche Diagnostics GMBH (patent document 21)
    • 6) International Laid-open Patent Application filed by Yamanouchi Pharmaceutical Co., Ltd. (patent document 22 and 23)
    • 7) Japanese Laid-open Patent Application filed by Japan Tabacco Inc. (Patent document 24)
    • Patent document 1 JP-A-10-72492
    • Patent document 2 WO96/40750
    • Patent document 3 WO96/40189
    • Patent document 4 WO98/25965
    • Patent document 5 JP-A-11-1477
    • Patent document 6 JP-A-11-152276
    • Patent document 7 WO01/07423
    • Patent document 8 WO01/53267
    • Patent document 9 WO02/059099
    • Patent document 10 WO02/059100
    • Patent document 11 WO00/35446
    • Patent document 12 WO00/66112
    • Patent document 13 WO01/34585
    • Patent document 14 WO01/17349
    • Patent document 15 WO01/39773
    • Patent document 16 WO01/21180
    • Patent document 17 WO01/89457
    • Patent document 18 WO02/49413
    • Patent document 19 WO02/085343
    • Patent document 20 JP-A-2001-97948
    • Patent document 21 WO99/11262
    • Patent document 22 WO02/062775
    • Patent document 23 WO03/062233
    • Patent document 24 JP-A-2003-238565
    • Non-patent document 1 Microvasc. Res., 1999: 58, p. 108-113
    • Non-patent document 2 Circ. Res., 1999: 84, p. 785-796
    • Non-patent document 3 Blood 2001:98, p. 71a-72a
    DISCLOSURE OF THE INVENTION
  • Thrombopoietin and low molecular weight peptides having affinity for the thrombopoietin receptor are likely to be easily degraded in the gastrointestinal tract and are usually difficult to orally administer. As to thrombopoietin itself, the appearance of anti thrombopoietin antibodies have been reported.
  • Besides, though it is probably possible to orally administer nonpeptidic low molecular weight compounds, no practical drugs have been put on the market.
  • Therefore, orally administrable low molecular weight compounds having excellent affinity for and agonistic action on the thrombopoietin receptor as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective have been demanded. Specifically, low molecular weight compounds which can serve as platelet increasing agents or increasing agents for other blood cells by stimulating differentiation and proliferation of hematopoietic stem cells, megakaryocytic progenitor cells and megakaryocytes or low molecular weight compounds which can be used for therapeutic angiogenesis or as preventive and therapeutic agents for arteriosclerosis by stimulating endothelial cells and endothelial progenitor cells have been demanded.
  • The present inventors conducted extensive research to find low molecular weight compounds having affinity for and agonistic action on the thrombopoietin receptor, and as a result, found that the compounds of the present invention have high affinity and agonistic action which enable them to show potent platelet increasing action by stimulating differentiation and proliferation of megakaryocytic progenitor cells and megakaryocytes. The present invention was accomplished on the basis of this discovery.
  • Namely, the present invention relates to:
  • 1. A compound represented by the formula (1)
  • Figure US20140051857A1-20140220-C00002
  • wherein A is a nitrogen atom or CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-4 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy is group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))),
  • B is an oxygen atom, a sulfur atom or NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)) (provided that when A is a nitrogen atom, B is not NH),
  • R1 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro, group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or two substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more. C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))),
  • L1 is a bond, CR10R11 (wherein each of R10 and R11 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR12 (wherein R12 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
  • X is OR13, SR13 or NR14R15 (wherein R13 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), and each of R14 and R15 is independently a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a, C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
  • R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group, (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group),
  • L2 is a bond, CR34R35 (wherein each of R34 and R35 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR16 (wherein R16 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
  • L3 is a bond, CR17R18 (wherein each of R17 and R18 is independently a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl-group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), an oxygen atom, a sulfur atom or NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl is group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
  • L4 is a bond, CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-34 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group, may be optionally substituted with one or more substituents selected from the group consisting of: C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C2-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
  • Y is an oxygen atom, a sulfur atom or NR23 (wherein R23 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group; the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and
  • R3 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents independently represented by —W1(CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a C1-6 alkyl group, (the C1-6 alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a C1-6 alkyl group, a formyl group or a C1-6 alkylcarbonyl group), each of W2 and W3 is independently a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, a amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a thiol group, a phosphonic acid group, a sulfonic acid group, a tetrazole group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a formyl group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R29 and R30, together with each other means —(CH2)m3-G-(CH2)m4— (wherein G is an oxygen atom, sulfur atom, a CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))), a tetrazole group, or a phosphonic acid group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • 2. The compound according to 1, wherein A is a nitrogen atom, and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    3. The compound according to 1, wherein A is a nitrogen atom, and B is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    4. The compound according to 1, wherein A is a nitrogen atom, and B is NR9 (wherein R9 is a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C2-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    5. The compound according to 1, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C2-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-34 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    6. The compound according to 1, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6, alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group; an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents is selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, hydroxyl group or a protected hydroxyl group) or NRB (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    7. The compound according to 1, wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy is group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may, be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-34 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl, group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and
  • B is NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • 8. The compound according to 1, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    9. The compound according to 2, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    10. The compound according to 3, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    11. The compound according to 4, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    12. The compound according to 5, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    13. The compound according to 6, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    14. The compound according to 7, wherein L1 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    15. The compound according to 1, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    16. The compound according to 2, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    17. The compound according to 3, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    18. The compound according to 4, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    19. The compound according to 5, wherein L2 is a bond, tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    20. The compound according to 6, wherein L2 is a bond, tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    21. The compound according to 7, wherein L2 is a bond, tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    22. The compound according to 8, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    23. The compound according to 9, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    24. The compound according to 10, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    25. The compound according to 11, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    26. The compound according to 12, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    27. The compound according to 13, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    28. The compound according to 14, wherein L2 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    29. The compound according to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 or 28, wherein L3 is NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    30. The compound according to 1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 or 28, wherein L3 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    31. The compound according to 29, wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    32. The compound according to 30, wherein L4 is the same as defined in 31, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    33. The compound according to 29, wherein L4 is NH, tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    34. The compound according to 30, wherein L4 is NH, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    35. The compound according to 29, wherein L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    36. The compound according to 30, wherein L4 is a bond, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    37. The compound according to 31, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    38. The compound according to 32, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    39. The compound according to 33, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    40. The compound according to 34, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    41. The compound according to 35, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    42. The compound according to 36, wherein Y is an oxygen atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    43. The compound according to 31, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    44. The compound according to 32, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    45. The compound according to 33, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    46. The compound according to 34, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    47. The compound according to 35, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    48. The compound according to 36, wherein Y is a sulfur atom, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    49. The compound according to 37, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    50. The compound according to 38, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    51. The compound according to 39, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    52. The compound according to 40, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    53. The compound according to 41, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    54. The compound according to 42, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    55. The compound according to 43, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    56. The compound according to 44, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    57. The compound according to 45, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    58. The compound according to 46, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    59. The compound according to 47, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    60. The compound according to 48, wherein X is a hydroxyl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    61. The compound according to 37, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    62. The compound according to 38, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    63. The compound according to 39, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    64. The compound according to 40, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    65. The compound according to 41, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    66. The compound according to 42, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    67. The compound according to 49, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    68. The compound according to 50, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    69. The compound according to 51, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    70. The compound according to 52, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    71. The compound according to 53, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    72. The compound according to 54, wherein R3 is the same as defined in 61, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    73. The compound according to 43, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole, group and a C1-10 alkoxycarbonyl group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    74. The compound according to 44, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    75. The compound according to 45, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    76. The compound according to 46, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    77. The compound according to 47, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    78. The compound according to 48, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    79. The compound according to 55, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    80. The compound according to 56, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    81. The compound according to 57, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    82. The compound according to 58, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    83. The compound according to 59, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    84. The compound according to 60, wherein R3 is the same as defined in 73, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    85. The compound according to 37, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    86. The compound according to 38, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    87. The compound according to 39, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    88. The compound according to 40, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    89. The compound according to 41, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    90. The compound according to 42, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    91. The compound according to 49, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    92. The compound according to 50, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    93. The compound according to 51, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    94. The compound according to 52, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    95. The compound according to 53, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    96. The compound according to 54, wherein R3 is the same as defined in 85, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    97. The compound according to 43, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a is solvate thereof.
    98. The compound according to 44, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    99. The compound according to 45, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    100. The compound according to 46, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    101. The compound according to 47, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    102. The compound according to 48, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    103. The compound according to 55, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    104. The compound according to 56, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    105. The compound according to 57, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    106. The compound according to 58, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    107. The compound according to 59, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    108. The compound according to 60, wherein R3 is the same as defined in 97, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    109. The compound according to 37, wherein R is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
  • a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
  • and one or more substituents selected from the group consisting of:
  • a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • 110. The compound according to 38, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    111. The compound according to 39, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    112. The compound according to 40, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    113. The compound according to 41, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    114. The compound according to 42, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    115. The compound according to 49, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    116. The compound according to 50, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    117. The compound according to 51, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    118. The compound according to 52, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    119. The compound according to 53, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    120. The compound according to 54, wherein R3 is the same as defined in 109, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    121. The compound according to 43, wherein R3 is a C2-14 aryl group (the C2-14 aryl group is optionally substituted with one or more substituents selected from the group consisting of:
  • a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group and a C1-10 alkoxycarbonyl group
  • and one or more substituents selected from the group consisting of:
  • a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
  • 122. The compound according to 44, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    123. The compound according to 45, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    124. The compound according to 46, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    125. The compound according to 47, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    126. The compound according to 48, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    127. The compound according to 55, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    128. The compound according to 56, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    129. The compound according to 57, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    130. The compound according to 58, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    131. The compound according to 59, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    132. The compound according to 60, wherein R3 is the same as defined in 121, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
    133. The thrombopoietin receptor activator according to 1.
    134. The thrombopoietin receptor activator according to 2.
    135. The thrombopoietin receptor activator according to 3.
    136. The thrombopoietin receptor activator according to 4.
    137. The thrombopoietin receptor activator according to 5.
    138. The thrombopoietin receptor activator according to 6.
    139. The thrombopoietin receptor activator according to 7.
    140. The thrombopoietin receptor activator according to any one of 8 to 14.
    141. The thrombopoietin receptor activator according to any one of 15 to 28.
    142. The thrombopoietin receptor activator according to 29.
    143. The thrombopoietin receptor activator according to 30.
    144. The thrombopoietin receptor activator according to 31 or 32.
    145. The thrombopoietin receptor activator according to 33 or 34.
    146. The thrombopoietin receptor activator according to 35 or 36.
    147. The thrombopoietin receptor activator according to any one of 37 to 42.
    148. The thrombopoietin receptor activator according to any one of 43 to 48.
    149. The thrombopoietin receptor activator according to any one of 49 to 54.
    150. The thrombopoietin receptor activator according to any one of 55 to 60.
    151. The thrombopoietin receptor activator according to any one of. 61 to 72.
    152. The thrombopoietin receptor activator according to any one of 73 to 84.
    153. The thrombopoietin receptor activator according to any one of 85 to 96.
    154. The thrombopoietin receptor activator according to any one of 97 to 108.
    155. The thrombopoietin receptor activator according to any one of 109 to 120.
    156. The thrombopoietin receptor activator according to any one of 121 to 132.
    157. A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective, which contains the thrombopoietin receptor activator according to any one of 133 to 156, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
    158. A platelet increasing agent containing the thrombopoietin receptor activator according to any one of 133 to 156, a tautomer, prodrug or pharmaceutically acceptable salt of the activator or a solvate thereof, as an active ingredient.
    159. Medicament containing the compound according to any one of 1 to 132, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, as an active ingredient.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows the proliferation of UT7/EPO-mpl cells when stimulated by the compound of the present invention (Synthetic Example 3).
  • FIG. 2 shows the proliferation of UT7/EPO cells when stimulated by the compound of the present invention (Synthetic Example 3).
    •  BEST MODE FOR CARRYING OUT THE INVENTION
  • Now, the present invention will be described in detail.
  • In the present invention, “n” denotes normal, “i” denotes iso, “s” denotes secondary, “t” denotes tertiary, “c” denotes cyclo, “o” denotes ortho, “m” denotes meta, “p” denotes para, “Ph” denotes phenyl, “Py” denotes pyridyl, “Ac” denotes acetyl, “Naphthyl” denotes naphthyl, “Me” denotes methyl, “Et” denotes ethyl, “Pr” denotes propyl, and “B” denotes butyl.
  • First, the terms in the respective substituents R1 to R36 will be explained.
  • As a halogen atom, a fluorine atom, a chlorine atom, a bromine atom or an iodine atom may be mentioned.
  • A C1-3 alkyl group may be linear, branched or a C3 cycloalkyl group, and methyl, ethyl, n-propyl, i-propyl and c-propyl and the like may be mentioned.
  • A C1-6 alkyl group may be linear, branched or a C3-6 cycloalkyl group, and in addition to those mentioned above, n-butyl, i-butyl, s-butyl, t-butyl, c-butyl, 1-methyl-c-propyl, 2-methyl-c-propyl, n-pentyl, 1-methyl-n-butyl, 2-methyl-n-butyl, 3-methyl-n-butyl, 1,1-dimethyl-n-propyl, 1,2-dimethyl-n-propyl, 2,2-dimethyl-n-propyl, 1-ethyl-n-propyl, c-pentyl, 1-methyl-c-butyl, 2-methyl-c-butyl, 3-methyl-c-butyl, 1,2-dimethyl-c-propyl, 2,3-dimethyl-c-propyl, 1-ethyl-c-propyl, 2-ethyl-c-propyl, n-hexyl, 1-methyl-n-pentyl, 2-methyl-n-pentyl, 3-methyl-n-pentyl, 4-methyl-n-pentyl, 1,1-dimethyl-n-butyl, 1,2-dimethyl-n-butyl, 1,3-dimethyl-n-butyl, 2,2-dimethyl-n-butyl, 2,3-dimethyl-n-butyl, 3,3-dimethyl-n-butyl, 1-ethyl-n-butyl, 2-ethyl-n-butyl, 1,1,2-trimethyl-n-propyl, 1,2,2-trimethyl-n-propyl, 1-ethyl-1-methyl-n-propyl, 1-ethyl-2-methyl-n-propyl, c-hexyl, 1-methyl-c-pentyl, 2-methyl-c-pentyl, 3-methyl-c-pentyl, 1-ethyl-c-butyl, 2-ethyl-c-butyl, 3-ethyl-c-butyl, 1,2-dimethyl-c-butyl, 1,3-dimethyl-c-butyl, 2,2-dimethyl-c-butyl, 2,3-dimethyl-c-butyl, 2,4-dimethyl-c-butyl, 3,3-dimethyl-c-butyl, 1-n-propyl-c-propyl, 2-n-propyl-c-propyl, 1-i-propyl-c-propyl, 2-i-propyl-c-propyl, 1,2,2-trimethyl-c-propyl, 1,2,3-trimethyl-c-propyl, 2,2,3-trimethyl-c-propyl, 1-ethyl-2-methyl-c-propyl, 2-ethyl-1-methyl-c-propyl, 2-ethyl-2-methyl-c-propyl, 2-ethyl-3-methyl-c-propyl and the like may be mentioned.
  • A C1-10 alkyl group may be linear, branched or a C3-10 cycloalkyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentyl, 1-heptyl, 2-heptyl, 1-ethyl-1,2-dimethyl-n-propyl, 1-ethyl-2,2-dimethyl-n-propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl, 6-methyl-2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-1-n-pentyl, 1-nonyl, 2-nonyl, 2,6-dimethyl-4-n-heptyl, 3-ethyl-2,2-dimethyl-3-n-pentyl, 3,5,5-trimethyl-1-n-hexyl, 1-decyl, 2-decyl, 4-decyl, 3,7-dimethyl-1-n-octyl, 3,7-dimethyl-3-n-octyl and the like may be mentioned.
  • As a C2-6 alkynyl group, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butyryl, 1,1-dimethyl-2-propynyl, 2-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 1-n-propyl-2-propynyl, 2-ethyl-3-butyryl, 1-methyl-1-ethyl-2-propynyl, 1-i-propyl-2-propynyl and the like may be mentioned.
  • A C2-6 alkenyl group may be linear, branched or a C3-6 cycloalkenyl group, and ethenyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, 1-ethylethenyl, 1-methyl-1-propenyl, 1-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-n-propylethenyl, 1-methyl-1-butenyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1-i-propylethenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-c-pentenyl, 2-c-pentenyl, 3-c-pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1-n-butylethenyl, 2-methyl-1-pentenyl, 2-methyl-2-pentenyl, 2-methyl-3-pentenyl, 2-methyl-4-pentenyl, 2-n-propyl-2-propenyl, 3-methyl-1-pentenyl, 3-methyl-2-pentenyl, 3-methyl-3-pentenyl, 3-methyl-4-pentenyl, 3-ethyl-3-butenyl, 4-methyl-1-pentenyl, 4-methyl-2-pentenyl, 4-methyl-3-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1-methyl-2-ethyl-2-propenyl, 1-s-butylethenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 1-i-butylethenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 2-i-propyl-2-propenyl, 3,3-dimethyl-1-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-n-propyl-1-propenyl, 1-n-propyl-2-propenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-t-butylethenyl, 1-methyl-1-ethyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl, 1-ethyl-2-methyl-2-propenyl, 1-i-propyl-1-propenyl, 1-i-propyl-2-propenyl, 1-methyl-2-c-pentenyl, 1-methyl-3-c-pentenyl, 2-methyl-1-c-pentenyl, 2-methyl-2-c-pentenyl, 2-methyl-3-c-pentenyl, 2-methyl-4-c-pentenyl, 2-methyl-5-c-pentenyl, 2-methylene-c-pentyl, 3-methyl-1-c-pentenyl, 3-methyl-2-c-pentenyl, 3-methyl-3-c-pentenyl, 3-methyl-4-c-pentenyl, 3-methyl-5-c-pentenyl, 3-methylene-c-pentyl, 1-c-hexenyl, 2-c-hexenyl, 3-c-hexenyl and the like may be mentioned.
  • A C2-14 aryl group may be a C6-14 aryl group containing no hetero atoms as ring constituting atoms or a C2-9 aromatic heterocyclic group, and a C2-9 aromatic heterocyclic group may be a 5 to 7-membered C2-6 heteromonocyclic group or 8 to 10-membered C5-9 fused heterobicyclic group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
  • As a C6-14 aryl group containing no hetero atoms, a phenyl group, a 1-indenyl group, a 2-indenyl group, a 3-indenyl group, a 4-indenyl group, a 5-indenyl group, a 6-indenyl group, a 7-indenyl group, an α-naphthyl group, a β-naphthyl group, a 1-tetrahydronaphthyl group, 2-tetrahydronaphthyl group, a 5-tetrahydronaphthyl group, a 6-tetrahydronaphthyl group, an o-biphenylyl group, a m-biphenylyl group, a p-biphenylyl group, a 1-anthryl group, a 2-anthryl group, a 9-anthryl group, a 1-phenanthryl group, a 2-phenanthryl group, a 3-phenanthryl group, a 4-phenanthryl group, a 9-phenanthryl group or the like may be mentioned.
  • A 5 to 7-membered C2-6 heteromonocyclic group may be a 2-thienyl group, a 3-thienyl group, a 2-furyl group, a 3-furyl group, a 2-pyranyl group, a 3-pyranyl group, a 4-pyranyl group, a 1-pyrrolyl group, a 2-pyrrolyl group, a 3-pyrrolyl group, a 1-imidazolyl group, a 2-imidazolyl group, a 4-imidazolyl group, a 1-pyrazolyl group, a 3-pyrazolyl group, a 4-pyrazolyl group, a 2-thiazolyl group, a 4-thiazolyl group, a 5-thiazolyl group, a 3-isothiazolyl group, a 4-isothiazolyl group, a 5-isothiazolyl group, a 2-oxazolyl group, a 4-oxazolyl group, a 5-oxazolyl group, a 3-isoxazolyl group, a 4-isoxazolyl group, a 5-isoxazolyl group, a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2-pyrazinyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group, a 5-pyrimidinyl group, a 3-pyridazinyl group, a 4-pyridazinyl group, a 2-1,3,4-oxadiazolyl group, a 2-1,3,4-thiadiazolyl group, a 3-1,2,4-oxadiazolyl group, a 5-1,2,4-oxadiazolyl group, a 3-1,2,4-thiadiazolyl group, a 5-1,2,4-thiadiazolyl group, a 3-1,2,5-oxadiazolyl group, a 3-1,2,5-thiadiazolyl group or the like.
  • A 8 to 10-membered C5-9 fused heterocyclic group may be a 2-benzofuranyl group, a 3-benzofuranyl group, a 4-benzofuranyl group, a 5-benzofuranyl group, a 6-benzofuranyl group, a 7-benzofuranyl group, a 1-isobenzofuranyl group, a 4-isobenzofuranyl group, a 5-isobenzofuranyl group, a 2-benzothienyl group, a 3-benzothienyl group, a 4-benzothienyl group, a 5-benzothienyl group, a 6-benzothienyl group, a 7-benzothienyl group, a 1-isobenzothienyl group, a 4-isobenzothienyl group, a 5-isobenzothienyl group, a 2-chromenyl group, a 3-chromenyl group, a 4-chromenyl group, a 5-chromenyl group, a 6-chromenyl group, a 7-chromenyl group, a 8-chromenyl group, a 1-indolizinyl group, a 2-indolizinyl group, a 3-indolizinyl group, a 5-indolizinyl group, a 6-indolizinyl group, a 7-indolizinyl group, a 8-indolizinyl group, a 1-isoindolyl group, a 2-isoindolyl group, a 4-isoindolyl group, a 5-isoindolyl group, a 1-indolyl group, a 2-indolyl group, a 3-indolyl group, a 4-indolyl group, a 5-indolyl group, a 6-indolyl group, a 7-indolyl group, 1-indazolyl group, a 2-indazolyl group, a 3-indazolyl group, 4-indazolyl group, a 5-indazolyl group, a 6-indazolyl group, a 7-indazolyl group, a 1-purinyl group, a 2-purinyl group, 3-purinyl group, a 6-purinyl group, a 7-purinyl group, 8-purinyl group, a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group, a 8-quinolyl group, a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, 7-isoquinolyl group, a 8-isoquinolyl group, a 1-phthalazinyl group, a 5-phthalazinyl group, a 6-phthalazinyl group, a 1-2,7-naphthyridinyl group, a 3-2,7-naphthyridinyl group, a 4-2,7-naphthyridinyl group, a 1-2,6-naphthyridinyl group, a 3-2,6-naphthyridinyl group, a 4-2,6-naphthyridinyl group, a 2-1,8-naphthyridinyl group, a 3-1,8-naphthyridinyl group, a 4-1,8-naphthyridinyl group, a 2-1,7-naphthyridinyl group, a 3-1,7-naphthyridinyl group, a 4-1,7-naphthyridinyl group, a 5-1,7-naphthyridinyl group, a 6-1,7-naphthyridinyl group, a 8-1,7-naphthyridinyl group, 2-1,6-naphthyridinyl group, a 3-1,6-naphthyridinyl group, a 4-1,6-naphthyridinyl group, a 5-1,6-naphthyridinyl group, a 7-1,6-naphthyridinyl group, a 8-1,6-naphthyridinyl group, a 2-1,5-naphthyridinyl group, a 3-1,5-naphthyridinyl group, a 4-1,5-naphthyridinyl group, a 6-1,5-naphthyridinyl group, a 7-1,5-naphthyridinyl group, a 8-1,5-naphthyridinyl group, a 2-quinoxalinyl group, a 5-quinoxalinyl group, a 6-quinoxalinyl group, a 2-quinazolinyl group, a 4-quinazolinyl group, a 5-quinazolinyl group, a 6-quinazolinyl group, a 7-quinazolinyl group, a 8-quinazolinyl group, a 3-cinnolinyl group, a 4-cinnolinyl group, a 5-cinnolinyl group, a 6-cinnolinyl group, a 7-cinnolinyl group, a 8-cinnolinyl group, a 2-pterdinyl group, a 4-pterdinyl group, a 6-pterdinyl group, a 7-pterdinyl group or the like.
  • A C2-14 aryloxy group may be a C6-14 aryloxy group containing no hetero atoms as ring constituting atoms or a C2-9 aromatic heterocyclic oxy group, and a C2-9 aromatic heterocyclic oxy group may be a 5 to 7-membered C2-6 heteromonocyclic oxy group or 8 to 10-membered C5-9 fused heterobicyclic oxy group containing from 1 to 3 oxygen atoms, nitrogen atoms or sulfur atoms singly or in combination.
  • As a C6-14 aryloxy group containing no hetero atoms, a phenyloxy group, a 1-indenyloxy group, a 2-indenyloxy group, a 3-indenyloxy group, a 4-indenyloxy group, a 5-indenyloxy group, a 6-indenyloxy group, a 7-indenyloxy group, an α-naphthyloxy group, a β-naphthyloxy group, a 1-tetrahydronaphthyloxy group, a 2-tetrahydronaphthyloxy group, a 5-tetrahydronaphthyloxy group, a 6-tetrahydronaphthyloxy group, an o-biphenylyloxy group, a m-biphenylyloxy group, a p-biphenylyloxy group, a 1-anthryloxy group, a 2-anthryloxy group, a 9-anthryloxy group, a 1-phenanthryloxy group, a 2-phenanthryloxy group, a 3-phenanthryloxy group, a 4-phenanthryloxy group, a 9-phenanthryloxy group or the like may be mentioned.
  • A 5 to 7-membered C2-6 heteromonocyclic oxy group may be a 2-thienyloxy group, a 3-thienyloxy group, a 2-furyloxy group, a 3-furyloxy group, a 2-pyranyloxy group, a 3-pyranyloxy group, a 4-pyranyloxy group, a 1-pyrrolyloxy group, a 2-pyrrolyloxy group, a 3-pyrrolyloxy group, a 1-imidazolyloxy group, a 2-imidazolyloxy group, a 4-imidazolyloxy group, a 1-pyrazolyloxy group, a 3-pyrazolyloxy group, a 4-pyrazolyloxy group, a 2-thiazolyloxy group, a 4-thiazolyloxy group, a 5-thiazolyloxy group, a 3-isothiazolyloxy group, a 4-isothiazolyloxy group, a 5-isothiazolyloxy group, a 2-oxazolyloxy group, a 4-oxazolyloxy group, a 5-oxazolyloxy group, a 3-isoxazolyloxy group, a 4-isoxazolyloxy group, a 5-isoxazolyloxy group, a 2-pyridyloxy group, a 3-pyridyloxy group, a 4-pyridyloxy group, a 2-pyrazinyloxy group, a 2-pyrimidinyloxy group, a 4-pyrimidinyloxy group, a 5-pyrimidinyloxy group, a 3-pyridazinyloxy group, a 4-pyridazinyloxy group, a 2-1,3,4-oxadiazolyloxy group, a 2-1,3,4-thiadiazolyloxy group, a 3-1,2,4-oxadiazolyloxy group, a 5-1,2,4-oxadiazolyloxy group, a 3-1,2,4-thiadiazolyloxy group, a 5-1,2,4-thiadiazolyloxy group, a 3-1,2,5-oxadiazolyloxy group, a 3-1,2,5-thiadiazolyloxy group or the like.
  • A 8 to 10-membered C5-9 fused heterocyclic oxy group may be a 2-benzofuranyloxy group, a 3-benzofuranyloxy group, a 4-benzofuranyloxy group, a 5-benzofuranyloxy group, a 6-benzofuranyloxy group, a 7-benzofuranyloxy group, a 1-isobenzofuranyloxy group, a 4-isobenzofuranyloxy group, a 5-isobenzofuranyloxy group, a 2-benzothienyloxy group, a 3-benzothienyloxy group, a 4-benzothienyloxy group, a 5-benzothienyloxy group, a 6-benzothienyloxy group, a 7-benzothienyloxy group, a 1-isobenzothienyloxy group, a 4-isobenzothienyloxy group, a 5-isobenzothienyloxy group, a 2-chromenyloxy group, a 3-chromenyloxy group, a 4-chromenyloxy group, a 5-chromenyloxy group, a 6-chromenyloxy group, a 7-chromenyloxy group, a 8-chromenyloxy group, a 1-indolizinyloxy group, a 2-indolizinyloxy group, a 3-indolizinyloxy group, a 5-indolizinyloxy group, a 6-indolizinyloxy group, a 7-indolizinyloxy group, a 8-indolizinyloxy group, a 1-isoindolyloxy group, a 2-isoindolyloxy group, a 4-isoindolyloxy group, a 5-isoindolyloxy group, a 1-indolyloxy group, a 2-indolyloxy group, a 3-indolyloxy group, a 4-indolyloxy group, a 5-indolyloxy group, a 6-indolyloxy group, a 7-indolyloxy group, 1-indazolyloxy group, a 2-indazolyloxy group, a 3-indazolyloxy group, a 4-indazolyloxy group, a 5-indazolyloxy group, a 6-indazolyloxy group, a 7-indazolyloxy group, a 1-purinyloxy group, a 2-purinyloxy group, a 3-purinyloxy group, a 6-purinyloxy group, a 7-purinyloxy group, a 8-purinyloxy group, a 2-quinolyloxy group, a 3-quinolyloxy group, a 4-quinolyloxy group, a 5-quinolyloxy group, a 6-quinolyloxy group, a 7-quinolyloxy group, a 8-quinolyloxy group, a 1-isoquinolyloxy group, a 3-isoquinolyloxy group, a 4-isoquinolyloxy group, a 5-isoquinolyloxy group, a 6-isoquinolyloxy group, a 7-isoquinolyloxy group, a 8-isoquinolyloxy group, a 1-phthalazinyloxy group, a 5-phthalazinyloxy group, a 6-phthalazinyloxy group, a 1-2,7-naphthyridinyloxy group, a 3-2,7-naphthyridinyloxy group, a 4-2,7-naphthyridinyloxy group, a 1-2,6-naphthyridinyloxy group, a 3-2,6-naphthyridinyloxy group, a 4-2,6-naphthyridinyloxy group, a 2-1,8-naphthyridinyloxy group, a 3-1,8-naphthyridinyloxy group, a 4-1,8-naphthyridinyloxy group, a 2-1,7-naphthyridinyloxy group, a 3-1,7-naphthyridinyloxy group, a 4-1,7-naphthyridinyloxy group, a 5-1,7-naphthyridinyloxy group, a 6-1,7-naphthyridinyloxy group, a 8-1,7-naphthyridinyloxy group, 2-1,6-naphthyridinyloxy group, a 3-1,6-naphthyridinyloxy group, a 4-1,6-naphthyridinyloxy group, a 5-1,6-naphthyridinyloxy group, a 7-1,6-naphthyridinyloxy group, a 8-1,6-naphthyridinyloxy group, a 2-1,5-naphthyridinyloxy group, a 3-1,5-naphthyridinyloxy group, a 4-1,5-naphthyridinyloxy group, a 6-1,5-naphthyridinyloxy group, a 7-1,5-naphthyridinyloxy group, a 8-1,5-naphthyridinyloxy group, a 2-quinoxalinyloxy group, a 5-quinoxalinyloxy group, a 6-quinoxalinyloxy group, a 2-quinazolinyloxy group, a 4-quinazolinyloxy group, a 5-quinazolinyloxy group, a 6-quinazolinyloxy group, a 7-quinazolinyloxy group, a 8-quinazolinyloxy group, a 3-cinnolinyloxy group, a 4-cinnolinyloxy group, a 5-cinnolinyloxy group, a 6-cinnolinyloxy group, a 7-cinnolinyloxy group, a 8-cinnolinyloxy group, a 2-pterdinyloxy group, a 4-pterdinyloxy group, a 6-pterdinyloxy group, a 7-pterdinyloxy group or the like.
  • A C1-6 alkylcarbonyl group may linear, branched or a C3-6 cycloalkylcarbonyl group, and be methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, i-propylcarbonyl, c-propylcarbonyl, n-butylcarbonyl, i-butylcarbonyl, s-butylcarbonyl, t-butylcarbonyl, c-butylcarbonyl, 1-methyl-c-propylcarbonyl, 2-methyl-c-propylcarbonyl, n-pentylcarbonyl, 1-methyl-n-butylcarbonyl, 2-methyl-n-butylcarbonyl, 3-methyl-n-butylcarbonyl, 1,1-dimethyl-n-propylcarbonyl, 1,2-dimethyl-n-propylcarbonyl, 2,2-dimethyl-n-propylcarbonyl, 1-ethyl-n-propylcarbonyl, c-pentylcarbonyl, 1-methyl-c-butylcarbonyl, 2-methyl-c-butylcarbonyl, 3-methyl-c-butylcarbonyl, 1,2-dimethyl-c-propylcarbonyl, 2,3-dimethyl-c-propylcarbonyl, 1-ethyl-c-propylcarbonyl, 2-ethyl-c-propylcarbonyl, n-hexylcarbonyl, 1-methyl-n-pentylcarbonyl, 2-methyl-n-pentylcarbonyl, 3-methyl-n-pentylcarbonyl, 4-methyl-n-pentylcarbonyl, 1,1-dimethyl-n-butylcarbonyl, 1,2-dimethyl-n-butylcarbonyl, 1,3-dimethyl-n-butylcarbonyl, 2,2-dimethyl-n-butylcarbonyl, 2,3-dimethyl-n-butylcarbonyl, 3,3-dimethyl-n-butylcarbonyl, 1-ethyl-n-butylcarbonyl, 2-ethyl-n-butylcarbonyl, 1,1,2-trimethyl-n-propylcarbonyl, 1,2,2-trimethyl-n-propylcarbonyl, 1-ethyl-1-methyl-n-propylcarbonyl, 1-ethyl-2-methyl-n-propylcarbonyl, c-hexylcarbonyl, 1-methyl-c-pentylcarbonyl, 2-methyl-c-pentylcarbonyl, 3-methyl-c-pentylcarbonyl, 1-ethyl-c-butylcarbonyl, 2-ethyl-c-butylcarbonyl, 3-ethyl-c-butylcarbonyl, 1,2-dimethyl-c-butylcarbonyl, 1,3-dimethyl-c-butylcarbonyl, 2,2-dimethyl-c-butylcarbonyl, 2,3-dimethyl-c-butylcarbonyl, 2,4-dimethyl-c-butylcarbonyl, 3,3-dimethyl-c-butylcarbonyl, 1-n-propyl-c-propylcarbonyl, 2-n-propyl-c-propylcarbonyl, 1-i-propyl-c-propylcarbonyl, 2-i-propyl-c-propylcarbonyl, 1,2,2-trimethyl-c-propylcarbonyl, 1,2,3-trimethyl-c-propylcarbonyl, 2,2,3-trimethyl-c-propylcarbonyl, 1-ethyl-2-methyl-c-propylcarbonyl, 2-ethyl-1-methyl-c-propylcarbonyl, 2-ethyl-2-methyl-c-propylcarbonyl, 2-ethyl-3-methyl-c-propylcarbonyl or the like may be mentioned.
  • A C1-10 alkylcarbonyl may be linear, branched or a C3-10 cycloalkylcarbonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl-n-pentylcarbonyl, 1-heptylcarbonyl, 2-heptylcarbonyl, 1-ethyl-1,2-dimethyl-n-propylcarbonyl, 1-ethyl-2,2-dimethyl-n-propylcarbonyl, 1-octylcarbonyl, 3-octylcarbonyl, 4-methyl-3-n-heptylcarbonyl, 6-methyl-2-n-heptylcarbonyl, 2-propyl-1-n-heptylcarbonyl, 2,4,4-trimethyl-1-n-pentylcarbonyl, 1-nonylcarbonyl, 2-nonylcarbonyl, 2,6-dimethyl-4-n-heptylcarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyl, 3,5,5-trimethyl-1-n-hexylcarbonyl, 1-decylcarbonyl, 2-decylcarbonyl, 4-decylcarbonyl, 3,7-dimethyl-1-n-octylcarbonyl, 3,7-dimethyl-3-n-octylcarbonyl or the like may be mentioned.
  • A C1-10 alkoxy group may be linear, branched or a C3-10 cycloalkoxy group, and methoxy, ethoxy, n-propoxy, i-propoxy, c-propoxy, n-butoxy, i-butoxy, s-butoxy, t-butoxy, c-butoxy, 1-methyl-c-propoxy, 2-methyl-c-propoxy, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, c-pentyloxy, 1-methyl-c-butoxy, 2-methyl-c-butoxy, 3-methyl-c-butoxy, 1,2-dimethyl-c-propoxy, 2,3-dimethyl-c-propoxy, 1-ethyl-c-propoxy, 2-ethyl-c-propoxy, n-hexyloxy, 1-methyl-n-pentyloxy, 2-methyl-n-pentyloxy, 3-methyl-n-pentyloxy, 4-methyl-n-pentyloxy, 1,1-dimethyl-n-butoxy, 1,2-dimethyl-n-butoxy, 1,3-dimethyl-n-butoxy, 2,2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3-dimethyl-n-butoxy, 1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1,1,2-trimethyl-n-propoxy, 1,2,2-trimethyl-n-propoxy, 1-ethyl-1-methyl-n-propoxy, 1-ethyl-2-methyl-n-propoxy, c-hexyloxy, 1-methyl-c-pentyloxy, 2-methyl-c-pentyloxy, 3-methyl-c-pentyloxy, 1-ethyl-c-butoxy, 2-ethyl-c-butoxy, 3-ethyl-c-butoxy, 1,2-dimethyl-c-butoxy, 1,3-dimethyl-c-butoxy, 2,2-dimethyl-c-butoxy, 2,3-dimethyl-c-butoxy, 2,4-dimethyl-c-butoxy, 3,3-dimethyl-c-butoxy, 1-n-propyl-c-propoxy, 2-n-propyl-c-propoxy, 1-i-propyl-c-propoxy, 2-1-propyl-c-propoxy, 1,2,2-trimethyl-c-propoxy, 1,2,3-trimethyl-c-propoxy, 2,2,3-trimethyl-c-propoxy, 1-ethyl-2-methyl-c-propoxy, 2-ethyl-1-methyl-c-propoxy, 2-ethyl-2-methyl-c-propoxy, 2-ethyl-3-methyl-c-propoxy, 1-methyl-1-ethyl-n-pentyloxy, 1-heptyloxy, 2-heptyloxy, 1-ethyl-1,2-dimethyl-n-propyloxy, 1-ethyl-2,2-dimethyl-n-propyloxy, 1-octyloxy, 3-octyloxy, 4-methyl-3-n-heptyloxy, 6-methyl-2-n-heptyloxy, 2-propyl-1-n-heptyloxy, 2,4,4-trimethyl-1-n-pentyloxy, 1-nonyloxy, 2-nonyloxy, 2,6-dimethyl-4-n-heptyloxy, 3-ethyl-2,2-dimethyl-3-n-pentyloxy, 3,5,5-trimethyl-1-n-hexyloxy, 1-decyloxy, 2-decyloxy, 4-decyloxy, 3,7-dimethyl-1-n-octyloxy, 3,7-dimethyl-3-n-octyloxy or the like may be is mentioned.
  • A C1-6 alkoxycarbonyl group may be linear, branched or a C3-6 cycloalkoxycarbonyl group, and methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, c-propylcarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, s-butoxycarbonyl, t-butoxycarbonyl, c-butoxycarbonyl, 1-methyl-c-propoxycarbonyl, 2-methyl-c-propoxycarbonyl, n-pentyloxycarbonyl, 1-methyl-n-butoxycarbonyl, 2-methyl-n-butoxycarbonyl, 3-methyl-n-butoxycarbonyl, 1,1-dimethyl-n-propoxycarbonyl, 1,2-dimethyl-n-propoxycarbonyl, 2,2-dimethyl-n-propoxycarbonyl, 1-ethyl-n-propoxycarbonyl, c-pentyloxycarbonyl, 1-methyl-c-butoxycarbonyl, 2-methyl-c-butoxycarbonyl, 3-methyl-c-butoxycarbonyl, 1,2-dimethyl-c-propoxycarbonyl, 2,3-dimethyl-c-propoxycarbonyl, 1-ethyl-c-propoxycarbonyl, 2-ethyl-c-propoxycarbonyl, n-hexyloxycarbonyl, 1-methyl-n-pentyloxycarbonyl, 2-methyl-n-pentyloxycarbonyl, 3-methyl-n-pentyloxycarbonyl, 4-methyl-n-pentyloxycarbonyl, 1,1-dimethyl-n-butoxycarbonyl, 1,2-dimethyl-n-butoxycarbonyl, 1,3-dimethyl-n-butoxycarbonyl, 2,2-dimethyl-n-butoxycarbonyl, 2,3-dimethyl-n-butoxycarbonyl, 3,3-dimethyl-n-butoxycarbonyl, 1-ethyl-n-butoxycarbonyl, 2-ethyl-n-butoxycarbonyl, 1,1,2-trimethyl-n-propoxycarbonyl, 1,2,2-trimethyl-n-propoxycarbonyl, 1-ethyl-1-methyl-n-propoxycarbonyl, 1-ethyl-2-methyl-n-propoxycarbonyl, c-hexyloxycarbonyl, 1-methyl-c-pentyloxycarbonyl, 2-methyl-c-pentyloxycarbonyl, 3-methyl-c-pentyloxycarbonyl, 1-ethyl-c-butoxycarbonyl, 2-ethyl-c-butoxycarbonyl, 3-ethyl-c-butoxycarbonyl, 1,2-dimethyl-c-butoxycarbonyl, 1,3-dimethyl-c-butoxycarbonyl, 2,2-dimethyl-c-butoxycarbonyl, 2,3-dimethyl-c-butoxycarbonyl, 2,4-dimethyl-c-butoxycarbonyl, 3,3-dimethyl-c-butoxycarbonyl, 1-n-propyl-c-propoxycarbonyl, 2-n-propyl-c-propoxycarbonyl, 1-i-propyl-c-propoxycarbonyl, 2-i-propyl-c-propoxycarbonyl, 1,2,2-trimethyl-c-propoxycarbonyl, 1,2,3-trimethyl-c-propoxycarbonyl, 2,2,3-trimethyl-c-propoxycarbonyl, 1-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-1-methyl-c-propoxycarbonyl, 2-ethyl-2-methyl-c-propoxycarbonyl, 2-ethyl-3-methyl-c-propoxycarbonyl or the like may be mentioned.
  • A C1-10 alkoxycarbonyl group may be linear, branched or a C3-10 cycloalkoxycarbonyl group, and in addition to those mentioned above, 1-methyl-1-ethyl=n-pentyloxycarbonyl, 1-heptyloxycarbonyl, 2-heptyloxycarbonyl, 1-ethyl-1,2-dimethyl-n-propyloxycarbonyl, 1-ethyl-2,2-dimethyl-n-propyloxycarbonyl, 1-octyloxycarbonyl, 3-octyloxycarbonyl, 4-methyl-3-n-heptyloxycarbonyl, 6-methyl-2-n-heptyloxycarbonyl, 2-propyl-1-n-heptyloxycarbonyl, 2,4,4-trimethyl-1-n-pentyloxycarbonyl, 1-nonyloxycarbonyl, 2-nonyloxycarbonyl, 2,6-dimethyl-4-n-heptyloxycarbonyl, 3-ethyl-2,2-dimethyl-3-n-pentyloxycarbonyl, 3,5,5-trimethyl-1-n-hexyloxycarbonyl, 1-decyloxycarbonyl, 2-decyloxycarbonyl, 4-decyloxycarbonyl, 3,7-dimethyl-1-n-octyloxycarbonyl, 3,7-dimethyl-3-n-octyloxycarbonyl or the like may be mentioned.
  • A C1-10 alkylcarbonyloxy group may be linear, branched or a C3-10 cycloalkylcarbonyloxy group, and methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, i-propylcarbonyloxy, c-propylcarbonyloxy, n-butylcarbonyloxy, i-butylcarbonyloxy, s-butylcarbonyloxy, t-butylcarbonyloxy, c-butylcarbonyloxy, 1-methyl-c-propylcarbonyloxy, methyl-c-propylcarbonyloxy, n-pentylcarbonyloxy, 1-methyl-n-butylcarbonyloxy, 2-methyl-n-butylcarbonyloxy, 3-methyl-n-butylcarbonyloxy, 1,1-dimethyl-n-propylcarbonyloxy, 1,2-dimethyl-n-propylcarbonyloxy, 2,2-dimethyl-n-propylcarbonyloxy, 1-ethyl-n-propylcarbonyloxy, c-pentylcarbonyloxy, 1-methyl-c-butylcarbonyloxy, 2-methyl-c-butylcarbonyloxy, 3-methyl-c-butylcarbonyloxy, 1,2-dimethyl-c-propylcarbonyloxy, 2,3-dimethyl-c-propylcarbonyloxy, 1-ethyl-c-propylcarbonyloxy, 2-ethyl-c-propylcarbonyloxy, n-hexylcarbonyloxy, 1-methyl-n-pentylcarbonyloxy, 2-methyl-n-pentylcarbonyloxy, 3-methyl-n-pentylcarbonyloxy, 4-methyl-n-pentylcarbonyloxy, 1,1-dimethyl-n-butylcarbonyloxy, 1,2-dimethyl-n-butylcarbonyloxy, 1,3-dimethyl-n-butylcarbonyloxy, 2,2-dimethyl-n-butylcarbonyloxy, 2,3-dimethyl-n-butylcarbonyloxy, 3,3-dimethyl-n-butylcarbonyloxy, 1-ethyl-n-butylcarbonyloxy, 2-ethyl-n-butylcarbonyloxy, 1,1,2-trimethyl-n-propylcarbonyloxy, 1,2,2-trimethyl-n-propylcarbonyloxy, 1-ethyl-1-methyl-n-propylcarbonyloxy, 1-ethyl-2-methyl-n-propylcarbonyloxy, c-hexylcarbonyloxy, 1-methyl-c-pentylcarbonyloxy, 2-methyl-c-pentylcarbonyloxy, 3-methyl-c-pentylcarbonyloxy, 1-ethyl-c-butylcarbonyloxy, 2-ethyl-c-butylcarbonyloxy, 3-ethyl-c-butylcarbonyloxy, 1,2-dimethyl-c-butylcarbonyloxy, 1,3-dimethyl-c-butylcarbonyloxy, 2,2-dimethyl-c-butylcarbonyloxy, 2,3-dimethyl-c-butylcarbonyloxy, 2,4-dimethyl-c-butylcarbonyloxy, 3,3-dimethyl-c-butylcarbonyloxy, 1-n-propyl-c-propylcarbonyloxy, 2-n-propyl-propylcarbonyloxy, 1-i-propyl-c-propycarbonyloxy, 2-i-propyl-c-propylcarbonyloxy, 1,2,2-trimethyl-c-propylcarbonyloxy, 1,2,3-trimethyl-c-propylcarbonyloxy, 2,2,3-trimethyl-c-propylcarbonyloxy, 1-ethyl-2-methyl-c-propylcarbonyloxy, 2-ethyl-1-methyl-c-propylcarbonyloxy, 2-ethyl-2-methyl-c-propylcarbonyloxy, 2-ethyl-3-methyl-c-propylcarbonyloxy, 1-methyl-1-ethyl-n-pentylcarbonyloxy, 1-heptylcarbonyloxy, 2-heptylcarbonyloxy, 1-ethyl-1,2-dimethyl-n-propylcarbonyloxy, 1-ethyl-2,2-dimethyl-n-propylcarbonyloxy, 1-octylcarbonyloxy, 3-octylcarbonyloxy, 4-methyl-3-n-heptylcarbonyloxy, 6-methyl-2-n-heptylcarbonyloxy, 2-propyl-1-n-heptylcarbonyloxy, 2,4,4-trimethyl-1-n-pentylcarbonyloxy, 1-nonylcarbonyloxy, 2-nonylcarbonyloxy, 2,6-dimethyl-4-n-heptylcarbonyloxy, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonyloxy, 3,5,5-trimethyl-1-n-hexylcarbonyloxy, 1-decylcarbonyloxy, 2-decylcarbonyloxy, 4-decylcarbonyloxy, 3,7-dimethyl-1-n-octylcarbonyloxy, 3,7-dimethyl-3-n-octylcarbonyloxy or the like may be mentioned.
  • A C1-10 alkylcarbonylamino group may be linear, branched or a C3-10 cycloalkylcarbonylamino group, and methylcarbonylamino, ethylcarbonylamino, n-propylcarbonylamino, i-propylcarbonylamino, c-propylcarbonylamino, n-butylcarbonylamino, butylcarbonylamino, s-butylcarbonylamino, t-butylcarbonylamino, c-butylcarbonylamino, 1-methyl-c-propylcarbonylamino, 2-methyl-c-propylcarbonylamino, n-pentylcarbonylamino, 1-methyl-n-butylcarbonylamino, 2-methyl-n-butylcarbonylamino, 3-methyl-n-butylcarbonylamino, 1,1-dimethyl-n-propylcarbonylamino, 1,2-dimethyl-n-propylcarbonylamino, 2,2-dimethyl-n-propylcarbonylamino, 1-ethyl-n-propylcarbonylamino, c-pentylcarbonylamino, 1-methyl-c-butylcarbonylamino, 2-methyl-c-butylcarbonylamino, 3-methyl-c-butylcarbonylamino, 1,2-dimethyl-c-propylcarbonylamino, 2,3-dimethyl-c-propylcarbonylamino, 1-ethyl-c-propylcarbonylamino, 2-ethyl-c-propylcarbonylamino, hexylcarbonylamino, 1-methyl-n-pentylcarbonylamino, methyl-n-pentylcarbonylamino, 3-methyl-n-pentylcarbonylamino, 4-methyl-n-pentylcarbonylamino, 1,1-dimethyl-n-butylcarbonylamino, 1,2-dimethyl-n-butylcarbonylamino, 1,3-dimethyl-n-butylcarbonylamino, 2,2-dimethyl-n-butylcarbonylamino, 2,3-dimethyl-n-butylcarbonylamino, 3,3-dimethyl-n-butylcarbonylamino, 1-ethyl-n-butylcarbonylamino, 2-ethyl-n-butylcarbonylamino, 1,1,2-trimethyl-n-propylcarbonylamino, 1,2,2-trimethyl-n-propylcarbonylamino, 1-ethyl-1-methyl-n-propylcarbonylamino, 1-ethyl-2-methyl-n-propylcarbonylamino, c-hexylcarbonylamino, 1-methyl-c-pentylcarbonylamino, 2-methyl-c-pentylcarbonylamino, 3-methyl-c-pentylcarbonylamino, 1-ethyl-c-butylcarbonylamino, 2-ethyl-c-butylcarbonylamino, 3-ethyl-c-butylcarbonylamino, 1,2-dimethyl-c-butylcarbonylamino, 1,3-dimethyl-c-butylcarbonylamino, 2,2-dimethyl-c-butylcarbonylamino, 2,3-dimethyl-butylcarbonylamino, 2,4-dimethyl-c-butylcarbonylamino, 3,3-dimethyl-c-butylcarbonylamino, 1-n-propyl-c-propylcarbonylamino, 2-n-propyl-c-propylcarbonylamino, 1-i-propyl-c-propylcarbonylamino, 2-i-propyl-propylcarbonylamino, 1,2,2-trimethyl-c-propyl-carbonylamino, 1,2,3-trimethyl-c-propylcarbonylamino, 2,2,3-trimethyl-c-propylcarbonylamino, 1-ethyl-2-methyl-c-propylcarbonylamino, 2-ethyl-1-methyl-c-propylcarbonylamino, 2-ethyl-2-methyl-c-propylcarbonylamino, 2-ethyl-3-methyl-c-propylcarbonylamino, 1-methyl-1-ethyl-n-pentylcarbonylamino, 1-heptylcarbonylamino, 2-heptylcarbonylamino, 1-ethyl-1,2-dimethyl-n-propylcarbonylamino, 1-ethyl-2,2-dimethyl-n-propylcarbonylamino, 1-octylcarbonylamino, 3-octylcarbonylamino, 4-methyl-3-n-heptylcarbonylamino, 6-methyl-2-n-heptylcarbonylamino, 2-propyl-1-n-heptylcarbonylamino, 2,4,4-trimethyl-1-n-pentylcarbonylamino, 1-nonylcarbonylamino, 2-nonylcarbonylamino, 2,6-dimethyl-4-n-heptylcarbonylamino, 3-ethyl-2,2-dimethyl-3-n-pentylcarbonylamino, 3,5,5-trimethyl-1-n-hexylcarbonylamino, 1-decylcarbonylamino, 2-decylcarbonylamino, 4-decylcarbonylamino, 3,7-dimethyl-1-n-octylcarbonylamino, 3,7-dimethyl-3-n-octylcarbonylamino or the like may be mentioned.
  • A C1-10 monoalkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and methylamino, ethylamino, n-propylamino, i-propylamino, c-propylamino, n-butylamino, i-butylamino, s-butylamino, t-butylamino, c-butylamino, 1-methyl-c-propylamino, 2-methyl-c-propylamino, n-pentylamino, 1-methyl-n-butylamino, 2-methyl-n-butylamino, 3-methyl-n-butylamino, 1,1-dimethyl-n-propylamino, 1,2-dimethyl-n-propylamino, 2,2-dimethyl-n-propylamino, 1-ethyl-n-propylamino, c-pentylamino, 1-methyl-c-butylamino, 2-methyl-c-butylamino, 3-methyl-c-butylamino, 1,2-dimethyl-c-propylamino, 2,3-dimethyl-n-propylamino, 1-ethyl-c-propylamino, 2-ethyl-c-propylamino, n-hexylamino, 1-methyl-n-pentylamino, 2-methyl-n-pentylamino, 3-methyl-n-pentylamino, 4-methyl-n-pentylamino, 1,1-dimethyl-n-butylamino, 1,2-dimethyl-n-butylamino, 1,3-dimethyl-n-butylamino, 2,2-dimethyl-n-butylamino, 2,3-dimethyl-n-butylamino, 3,3-dimethyl-n-butylamino, 1-ethyl-n-butylamino, 2-ethyl-n-butylamino, 1,1,2-trimethyl-n-propylamino, 1,2,2-trimethyl-n-propylamino, 1-ethyl-1-methyl-n-propylamino, 1-ethyl-2-methyl-n-propylamino, c-hexylamino, 1-methyl-c-pentylamino, 2-methyl-c-pentylamino, 3-methyl-c-pentylamino, 1-ethyl-c-butylamino, 2-ethyl-c-butylamino, 3-ethyl-c-butylamino, 1,2-dimethyl-c-butylamino, 1,3-dimethyl-c-butylamino, 2,2-dimethyl-c-butylamino, 2,3-dimethyl-c-butylamino, 2,4-dimethyl-c-butylamino, 3,3-dimethyl-c-butylamino, 1-n-propyl-c-propylamino, 2-n-propyl-c-propylamino, 1-i-propyl-c-propylamino, 2-i-propyl-c-propylamino, 1,2,2-trimethyl-c-propylamino, 1,2,3-trimethyl-c-propylamino, 2,2,3-trimethyl-c-propylamino, 1-ethyl-2-methyl-c-propylamino, 2-ethyl-1-methyl-c-propylamino, 2-ethyl-2-methyl-c-propylamino, 2-ethyl-3-methyl-c-propylamino, 1-methyl-1-ethyl-n-pentylamino, 1-heptylamino, 2-heptylamino, 1-ethyl-1,2-dimethyl-n-propylamino, 1-ethyl-2,2-dimethyl-n-propylamino, 1-octylamino, 3-octylamino, 4-methyl-3-n-heptylamino, 6-methyl-2-n-heptylamino, 2-propyl-1-n-heptylamino, 2,4,4-trimethyl-1-n-pentylamino, 1-nonylamino, 2-nonylamino, 2,6-dimethyl-4-n-heptylamino, 3-ethyl-2,2-dimethyl-3-n-pentylamino, 3,5,5-trimethyl-1-n-hexylamino, 1-decylamino, 2-decylamino, 4-decylamino, 3,7-dimethyl-1-n-octylamino, 3,7-dimethyl-3-n-octylamino or the like may be mentioned.
  • A C1-10 dialkylamino group may be symmetric or asymmetric. A symmetric C1-10 dialkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and dimethylamino, diethylamino, di-n-propylamino, di-1-propylamino, di-c-propylamino, di-n-butylamino, di-1-butylamino, di-s-butylamino, di-t-butylamino, d-c-butylamino, di-(1-methyl-c-propyl)amino, di-(2-methyl-c-propyl)amino, di-n-pentylamino, di-(1-methyl-n-butyl)amino, di-(2-methyl-n-butyl)amino, di-(3-methyl-n-butyl)amino, di-(1,1-dimethyl-n-propyl)amino, di-(1,2-dimethyl-n-propyl)amino, di-(2,2-dimethyl-n-propyl)amino, di-(1-ethyl-n-propyl)amino, di-c-pentylamino, di-(1-methyl-c-butyl)amino, di-(2-methyl-c-butyl)amino, di-(3-methyl-c-butyl)amino, di-(1,2-dimethyl-c-propyl)amino, di-(2,3-dimethyl-c-propyl)amino, di-(1-ethyl-c-propyl)amino, di-(2-ethyl-c-propyl)amino, di-n-hexylamino, di-(1-methyl-n-pentyl)amino, di-(2-methyl-n-pentyl)amino, di-(3-methyl-n-pentyl)amino, di-(4-methyl-n-pentyl)amino, di-(1,1-dimethyl-n-butyl)amino, di-(1,2-dimethyl-n-butyl)amino, di-(1,3-dimethyl-n-butyl)amino, di-(2,2-dimethyl-n-butyl)amino, di-(2,3-dimethyl-n-butyl)amino, di-(3,3-dimethyl-n-butyl)amino, di-(1-ethyl-n-butyl)amino, di-(2-ethyl-n-butyl)amino, di-(1,1,2-trimethyl-n-propyl)amino, di-(1,2,2-trimethyl-n-propyl)amino, di-(1-ethyl-1-methyl-n-propyl)amino, di-(1-ethyl-2-methyl-n-propyl)amino, di-c-hexylamino, di-(1-methyl-c-pentyl)amino, di-(2-methyl-c-pentyl)amino, di-(3-methyl-c-pentyl)amino, di-(1-ethyl-c-butyl)amino, di-(2-ethyl-c-butyl)amino, di-(3-ethyl-c-butyl)amino, di-(1,2-dimethyl-c-butyl)amino, di-(1,3-dimethyl-c-butyl)amino, di-(2,2-dimethyl-c-butyl)amino, di-(2,3-dimethyl-c-butyl)amino, di-(2,4-dimethyl-c-butyl)amino, di-(3,3-dimethyl-c-butyl)amino, di-(1-n-propyl-c-propyl)amino, di-(2-n-propyl-c-propyl)amino, di-(1-i-propyl-c-propyl)amino, di-(2-i-propyl-c-propyl)amino, di-(1,2,2-trimethyl-c-propyl)amino, di-(1,2,3-trimethyl-c-propyl)amino, di-(2,2,3-trimethyl-c-propyl)amino, di-(1-ethyl-2-methyl-c-propyl)amino, di-(2-ethyl-1-methyl-c-propyl)amino, di-(2-ethyl-2-methyl-c-propyl)amino, di-(2-ethyl-3-methyl-c-propyl)amino, di-(1-methyl-1-ethyl-n-pentyl)amino, di-(1-heptyl)amino, di-(2-heptyl)amino, di-(1-ethyl-1,2-dimethyl-n-propyl)amino, di-(1-ethyl-2,2-dimethyl-n-propyl)amino, di-(1-octyl)amino, di-(3-octyl)amino, di-(4-methyl-3-n-heptyl)amino, di-(6-methyl-2-n-heptyl)amino, di-(2-propyl-1-n-heptyl)amino, di-(2,4,4-trimethyl-1-n-pentyl)amino, di-(1-nonyl)amino, di-(2-nonyl)amino, di-(2,6-dimethyl-4-n-heptyl)amino, di-(3-ethyl-2,2-dimethyl-3-n-pentyl)amino, di-(3,5,5-trimethyl-1-n-hexyl)amino, di-(1-decyl)amino, di-(2-decyl)amino, di-(4-decyl)amino, di-(3,7-dimethyl-1-n-octyl)amino, di-(3,7-dimethyl-3-n-octyl)amino or the like may be mentioned.
  • An asymmetric C1-10 dialkylamino group may be linear, branched or a C3-10 cycloalkylamino group, and (methyl, ethyl)amino, (methyl, n-propyl)amino, (methyl, i-propyl)amino, (methyl, c-propyl)amino, (methyl, n-butyl)amino, (methyl, i-butyl)amino, (methyl, s-butyl)amino, (methyl, t-butyl)amino, (methyl, n-pentyl)amino, (methyl, c-pentyl)amino, (methyl, n-hexyl)amino, (methyl, c-hexyl)amino, (ethyl, n-propyl)amino, (ethyl, 1-propyl)amino, (ethyl, c-propyl)amino, (ethyl, n-butyl)amino, (ethyl, i-butyl)amino, (ethyl, s-butyl)amino, (ethyl, t-butyl)amino, (ethyl, n-pentyl)amino, (ethyl, c-pentyl)amino, (ethyl, n-hexyl)amino, (ethyl, hexyl)amino, (n-propyl, i-propyl)amino, (n-propyl, propyl)amino, (n-propyl, n-butyl)amino, (n-propyl, butyl)amino, (n-propyl, s-butyl)amino, (n-propyl, t-butyl)amino, (n-propyl, n-pentyl)amino, (n-propyl, c-pentyl)amino, (n-propyl, n-hexyl)amino, (n-propyl, c-hexyl)amino, (i-propyl, c-propyl)amino, (i-propyl, n-butyl)amino, (i-propyl, i-butyl)amino, (i-propyl, s-butyl)amino, (i-propyl, t-butyl)amino, (i-propyl, n-pentyl)amino, (i-propyl, c-pentyl)amino, (i-propyl, n-hexyl)amino, (i-propyl, c-hexyl)amino, (c-propyl, n-butyl)amino, (c-propyl, i-butyl)amino, (c-propyl, s-butyl)amino, (c-propyl, t-butyl)amino, (c-propyl, n-pentyl)amino, (c-propyl, c-pentyl)amino, (c-propyl, n-hexyl)amino, (c-propyl, c-hexyl)amino, (n-butyl, i-butyl)amino, (n-butyl, s-butyl)amino, (n-butyl, t-butyl)amino, (n-butyl, n-pentyl)amino, (n-butyl, c-pentyl)amino, (n-butyl, n-hexyl)amino, (n-butyl, c-hexyl)amino, (i-butyl, s-butyl)amino, (i-butyl, t-butyl)amino, (i-butyl, n-pentyl)amino, (i-butyl, c-pentyl)amino, (i-butyl, n-hexyl)amino, (i-butyl, n-hexyl)amino, (s-butyl, t-butyl)amino, (s-butyl, n-pentyl)amino, (s-butyl, c-pentyl)amino, (s-butyl, n-hexyl)amino, (s-butyl, c-hexyl)amino, (t-butyl, n-pentyl)amino, (t-butyl, c-pentyl)amino, (t-butyl, n-hexyl)amino, (t-butyl, c-hexyl)amino, (n-pentyl, c-pentyl)amino, (n-pentyl, n-hexyl)amino, (n-pentyl, c-hexyl)amino, (c-pentyl, n-hexyl)amino, (c-pentyl, c-hexyl)amino, (n-hexyl, c-hexyl)amino, (methyl, n-heptyl)amino, (methyl, n-octyl)amino, (methyl, n-nonanyl)amino, (methyl, n-decyl)amino, (methyl, n-heptyl)amino, (ethyl, n-octyl)amino, (ethyl, n-nonanyl)amino, (ethyl, n-decyl)amino or the like may be mentioned.
  • The protecting group in a protected hydroxyl group may be a C1-4 alkoxymethyl group (such as MOM: methoxymethyl, MEM: 2-methoxyethoxymethyl, ethoxymethyl, n-propoxymethyl, i-propoxymethyl, n-butoxymethyl, iBM: isobutyloxymethyl, BUM: t-butoxymethyl, POM: pivaloyloxymethyl, SEM: trimethylsilylethoxymethyl and the like, preferably a C1-2 alkoxymethyl or the like), an aryloxymethyl (such as BOM: benzyloxymethyl, PMBM: p-methoxybenzyloxymethyl, p-AOM: p-anisyloxymethyl and the like, preferably benzyloxymethyl or the like), a C1-4 alkylaminomethyl group (such as dimethylaminomethyl), a substituted acetamidomethyl group (such as Acm: acetamidomethyl, Tacm: trimethylacetamidemethyl and the like), a substituted thiomethyl group (such as MTM: methylthiomethyl, PTM: phenylthiomethyl, Btm: benzylthiomethyl and the like), a carboxyl group, a C1-7 acyl group (such as formyl, acetyl, fluoroacetyl, difluoroacetyl, trifluoroacetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, propionyl, Pv: pivaloyl, tigloyl and the like), an arylcarbonyl group (such as benzoyl, benzoylformyl, benzovlpropionyl, phenylpropionyl and the like), a C1-4 alkoxycarbonyl group (such as methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, propoxycarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, BOC: t-butoxycarbonyl, AOC: t-amyloxycarbonyl, VOC: vinyloxycarbonyl, AOC: allyloxycarbonyl, Teoc: 2-(trimethylsilyl)ethoxycarbonyl, Troc: 2,2,2-trichloroethoxycarbonyl and the like, preferably BOC and the like), an aryloxycarbonyl group (such as Z: benzyloxycarbonyl, p-nitrobenzyloxycarbonyl, MOZ: p-methoxybenzyloxycarbonyl and the like), a C1-4 alkylaminocarbonyl group (such as methylcarbamoyl, Ec: ethylcarbamoyl, n-propylcarbamoyl, and the like), an arylaminocarbonyl group (such as phenylcarbamoyl and the like), a trialkylsilyl group (such as TMS: trimethylsilyl, TES: triethylsilyl, TIPS: triisopropylsilyl, DEIPS: diethylisopropylsilyl, DMIPS: dimethylisopropylsilyl, DTBMS: di-t-butylmethylsilyl, IPDMS: isopropyldimethylsilyl, TBDMS: t-butyldimethylsilyl, TDS: thexyldimethylsilyl and the like, preferably t-butyldimethylsilyl and the like), a trialkylarylsilyl group (such as DPMS: diphenylmethylsilyl, TBDPS: t-butyldiphenylsilyl, TEMPS: t-butyldimethoxyphenylsilyl, TPS: triphenylsilyl and the like), an alkylsulfonyl group, (such as Ms: methanesulfonyl, ethanesulfonyl and the like) or an arylsulfonyl group (such as benzenesulfonyl, Ts: p-toluenesulfonyl, p-chlorobenzenesulfonyl, MBS: p-methoxybenzenesulfonyl, m-nitrobenzenesulfonyl, iMds: 2,6-dimethoxy-4-methylbenzenesulfonyl, Mds: 2,6-dimethyl-4-methoxybenzenesulfonyl, Mtb: 2,4,6-trimethoxybenzenesulfonyl, Mte: 2,3,5,6-tetramethyl-4-methoxybenzenesulfonyl, Mtr: 2,3,6-trimethyl-4-methoxybenzenesulfonyl, Mts: 2,4,6-s trimethylbenzenesulfonyl, Pme: pentamethylbenzenesulfonyl and the like).
  • Specific preferred examples of the substituent R1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
  • Substituents: a C1-10 alkyl group, a halogen atom, a alkyl group substituted with one or more halogen atoms, a nitro group, an amino group, an amino group substituted with one or two C1-10 alkyl groups, an amino group substituted with a C1-10 alkylcarbonyl group, a thiol group substituted with a C1-10 alkyl group, a thiol group substituted with a C1-10 alkylcarbonyl group, hydroxyl group, a C1-6 alkoxy group, a C1-10 alkoxy group substituted with one or more halogen atoms, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group and a C1-10 alkylcarbonyl group.
  • Particularly preferred examples of the substituent R1 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
  • Substituents: a methyl group, a t-butyl group, a trifluoromethyl group, a trifluoromethoxy group, a bromine atom, a chlorine atom, a fluorine atom, a methoxy group, a methylamino group, a dimethylamino group, a t-butyloxy group and a t-butylamino group.
  • Still further preferred specific examples of the substituent are a 3-methyl-phenyl group, a 4-methyl-phenyl group, a 3,4-dimethyl-phenyl group, a 3-t-butyl-phenyl group, a 4-t-butyl-phenyl group, a 3-trifluoromethyl-phenyl group, a 4-trifluoromethyl-phenyl group, a 4-trifluoromethoxy-phenyl group, a 4-bromo-phenyl group, a 3,4-ditrifluoromethyl-phenyl group, a 3-chloro-phenyl group, a 4-chloro-phenyl group, a 3-fluoro-phenyl group, a 4-fluoro-phenyl group, a 3,4-dichloro-phenyl group, 3,4-difluoro-phenyl group, a 4-methoxy-phenyl group, a 4-methylamino-phenyl group, a 4-methyl-2-thienyl group, a 5-methyl-2-thienyl group, a 4,5-dimethyl-2-thienyl group, a 4-t-butyl-2-thienyl group, a 5-t-butyl-2-thienyl group, a 4-trifluoromethyl-2-thienyl group, a 5-trifluoromethyl-2-thienyl group, a 4,5-ditrifluoromethyl-2-thienyl group, a 4-chloro-2-thienyl group, a 5-chloro-2-thienyl group, a 4-fluoro-2-thienyl group, a 5-fluoro-2-thienyl group, a 4,5-dichloro-2-thienyl group, 4,5-ditrifluoromethyl-2-thienyl group, a 5-methoxy-2-thienyl group, a 5-methylamino-2-thienyl. group, a 4-methyl-2-furyl group, a 5-methyl-2-furyl group, a 4,5-dimethyl-2-furyl group, a 4-t-butyl-2-furyl group, a 5-t-butyl-2-furyl group, a 4-trifluoromethyl-2-furyl group, a 5-trifluoromethyl-2-furyl group, a 4,5-ditrifluoromethyl-2-furyl group, a 4-chloro-2-furyl group, a 5-chloro-2-furyl group, a 4-fluoro-2-furyl group, a 5-fluoro-2-furyl group, a 4,5-dichloro-2-furyl group, a 5-methoxy-2-furyl group, a 5-methylamino-2-furyl group, a 6-chloro-3-pyridazinyl group, a 6-methyl-3-pyridazinyl group, a 6-methoxy-3-pyridazinyl group, a 6-chloro-3-pyridazinyl group, a 6-methylpyridazinyl group, a 6-methoxy-3-pyridazinyl group, a 6-t-butoxy-3-pyridazinyl group, a 5,6-dimethyl-3-pyridazinyl group, a 5,6-dichloro-3-pyridazinyl group, a 6-t-butyl-3-pyridazinyl group, a 5-chloro-2-pyridyl group, a 5-trifluoromethyl-2-pyridyl group, a 5-methyl-2-pyridyl group, a 4,5-dimethyl-2-pyridyl group, a 5,6-dimethyl-2-pyridyl group, a 5-t-butyl-2-pyridyl group, a 4,5-dichloro-2-pyridyl group, a 5,6-dichloro-2-pyridyl group and the like.
  • Specific preferable examples of L1 are a bond, CH2, a oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe2, N—CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
  • Specific preferable examples of the substituent R2 are a hydrogen atom, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t-butyl group, and a phenyl group (the methyl group, the ethyl group, the n-propyl group, the i-propyl group, the t-butyl group and the phenyl group may be optionally substituted with an amino group, a monomethylamino group, a dimethylamino group, a monoethylamino group, a diethylamino group, a methoxy group, an ethoxy group, a methoxycarbonyl group, an ethoxycarbonyl group, a methylcarbonyloxy group, an ethylcarbonyloxy group, a methylcarbonylamino group or an ethylcarbonylamino group and the like), and particularly preferable examples are a hydrogen atom, a methyl group, an ethyl group, a n-propyl group, an i-propyl group, a t-butyl group, a phenyl group and the like.
  • Specific preferable examples of L2 are a bond, CH2, oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe2, N—CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
  • Specific preferable examples, of L3 are a bond, CH2, an oxygen atom, a sulfur atom, NE, NH—OH, N-Me, N—CHO, CHMe, CMe2, N—CH2PH and the like, and particularly preferred examples are a bond, CH2, an oxygen atom, sulfur atom, NH, NMe and the like.
  • Specific preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
  • Substituents: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a hydroxycarbamido group, a cyanocarbamido group, a sulfamido group, a hydroxysulfamido group, a cyanosulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H, —CH2CH2CO2H, an alkoxycarbonyl group and the following heterocyclic groups substituted with a hydroxyl group.
  • Heterocyclic groups: a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group and a 1,2-thiazole group.
  • Still further, specific preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more substituents optionally selected from substituent set A and with one or more substituents optionally selected from substituent set B.
  • Substituent set A: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid, a carbamido group, a hydroxycarbamido group, a cyanocarbamido group, a sulfamido group, hydroxysulfamido group, a cyanosulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H, —CH2CH2CO2H and an alkoxycarbonyl group.
  • Substituent set B: an amino group, a nitro group, cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorines, a sulfamido group substituted with one or more C1-10 alkyl groups, carbamido group substituted with one or more C1-10 alkyl groups and a C1-10 alkylcarbonylamino group.
  • Specific particularly preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a. 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinoyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more of the following substituents.
  • Substituents: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H and —CH2CH2CO2H.
  • Still further, specific particularly preferable examples of the substituent R3 are a phenyl group, thienyl groups (a 2-thienyl group and a 3-thienyl group), furyl groups (a 2-furyl group and a 3-furyl group), pyridazinyl groups (a 3-pyridazinyl group and a 4-pyridazinyl group), pyridyl groups (a 2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group), quinolyl groups (a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group and a 8-quinolyl group) and isoquinolyl groups (a 1-isoquinolyl group, a 3-isoquinolyl group, a 4-isoquinolyl group, a 5-isoquinolyl group, a 6-isoquinolyl group, a 7-isoquinolyl group and a 8-isoquinolyl group) optionally substituted with one or more substituents optionally selected from substituent set A and with one or more substituents optionally selected from substituent set B.
  • Substituent set A: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a tetrazole group, —CH2CO2H, —OCH2CO2H, —NHCH2CO2H and —CH2CH2CO2H.
  • Substituent set B: an amino group, a nitro group, cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, carbamido group substituted with one or more C1-10 alkyl groups and a C1-10 alkylcarbonylamino group.
  • Specific preferable examples of L4 are a bond, CH2, an oxygen atom, a sulfur atom, NH, N-Me, N—CHO, CHMe, CMe2, N—CH2Ph and the like, and particularly preferred examples are a single bond, CH2, an oxygen atom, a sulfur atom, NH, NMe and the like.
  • Specific preferable examples of X are OH, SH, NH2, OMe, SMe, NHMe, NHEt, NH—CHO, NH—CH2Ph, OCH2Ph, SCH2Ph, OC(═O)CH3, SC(═O)CH3, NC(═O)CH3 and the like, and particularly preferred examples are OH, SH, NH2 and the like
  • Specific preferable examples of Y are an oxygen atom, a sulfur atom, NH, N—OH, N—CHO, N-Me, N—CH2Ph, N-OMe, N—OCH2Ph an the like, and particularly preferred examples are an oxygen atom, a sulfur atom, NH, N—OH and the like.
  • Favorable compounds as the thrombopoietin receptor activator, the preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective and the platelet increasing agent of the present invention are as follows.
  • 1) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 2) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 3) Compounds represented by the formula (1) wherein A is a nitrogen atom, and B is NR9 (wherein R9 is a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, cyano group, a halogen atom, a alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 4) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group; the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a c1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-34 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10, alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 5) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be, substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C2-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy-group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 6) Compounds represented by the formula (1) wherein A is CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more, halogen atoms) or one or more halogen atoms)), a C2-14 aryl group is (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group; a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or, di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl, group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy is group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))), and B is NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 7) Compounds represented by the formula (1) according to 4), 5) or 6) wherein A is CR37 (wherein R37 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be substituted with one or more substituents selected from the group consisting of: halogen atom, a carboxyl group, a nitro group and a cyano group), SO2R3B, SOR38 or COR38 (wherein R38 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the O2-6 alkynyl group and the C1-10 alkoxy group may be substituted with one or more substituents selected from the group consisting of: halogen atom, a carboxyl group, a nitro group and a cyano group), a C2-14 aryl group or a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the respective substituents R37 and R3B are the same as those in the respective substituents R1 to R36.
  • 8) Compounds represented by the formula (1) according to 3) or 6) wherein B is NR39 (wherein R39 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6, alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be substituted with one or more substituents selected from the group consisting of: a carboxyl group, a halogen atom, a nitro group and a cyano group), a C2-14 aryl group or a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be, substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group and a halogen atom)), tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The terms in the substituent R39 are the same as those in the respective substituents R1 to R36.
  • 9) Compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7) or 8) wherein L1 is a bond, tautomers prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 10) Compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7), 8) or 9) wherein L2 is a bond, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 11) Compounds represented by the formula (1) according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10) wherein L3 is NR19 (wherein R19 is a hydrogen atom, hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 12) The compounds according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10) wherein L3 is NH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 13) The compounds according to 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10) wherein L3 is CH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 14) The compounds according to 11), 12) or 13) wherein L4 is a bond, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 15) The compounds according to 11), 12) or 13) wherein L4 is NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 16) The compounds according to 11), 12) or 13) wherein L4 is NH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 17) The compounds according to 11), 12) or 13) wherein L4 is CH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 18) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the is C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group and the C1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), C1-12 aryl group or a C2-14 aryloxy group (the C2-14 aryl group and C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 19) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-3 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-3 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a phenyl group and a phenyloxy group (the phenyl group and the phenyloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a phenyl group or a phenyloxy group (the phenyl group and the phenyloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 20) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group or a C2-6 alkynyl group (the C1-10 alkyl group, the C2-6 alkenyl group and the C2-6 alkynyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 21) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 22) The compounds according to 14), 15), 16) or 17) wherein R2 is a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group and a protected hydroxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 23) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more substituents selected from the group consisting of: a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 24) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group; a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a thiol group and an amino (the thiol group and the amino group may be optionally substituted with one or more is substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 25) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group and a cyano group), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, a cyano group, a hydroxyl group and a protected is hydroxyl group))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 26) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 27) The compounds according to 18), 19), 20), 21) or 22) wherein R1 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group and a cyano group), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or more substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, a cyano group, a hydroxyl group and a protected hydroxyl group))), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 28) The compounds according to 23), 24), 25), 26) or 27) wherein Y is an oxygen atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 29) The compounds according to 23), 24), 25), 26) or 27) wherein Y is a sulfur atom, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 30) The compounds according to 28) or 29) wherein X is a hydroxyl group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 31) The compounds according to 28), 29) or 30) wherein R3 is a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups, a C1-10 alkoxycarbonyl group, a C1-10 alkoxy group, a C1-10 alkyl group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group (the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group, the C1-10 alkyl group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C2-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a mono- or di-C1-10 alkylamino group, a carboxyl group, a nitro group, a cyano group and a halogen atom)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 32) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups, a C1-10 alkoxycarbonyl group, a C1-10 alkoxy group, a C1-10 alkyl group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group (the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group, the C1-10 alkyl group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected, from the group consisting of: a hydroxyl group, an amino group, a mono- or di-C1-10 alkylamino group, a carboxyl, group, a nitro group, a cyano group and a halogen atom)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 33) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups, a C1-10 alkoxycarbonyl group, a C1-10 alkoxy group, a C1-10 alkyl group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkylcarbonylamino group and a mono- or di-C1-10 alkylamino group (the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group, the C1-10 alkyl group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a hydroxyl group, an amino group, a mono- or di-C1-10 alkylamino group, a carboxyl group, a nitro group, a cyano group and a halogen atom)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 34) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group, a tetrazole group, a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or more C1-10 alkyl groups, a carbamido group substituted with one or more C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 35) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 36) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 37) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with a carboxyl group, a phosphonic acid group, a sulfonic acid group or a tetrazole group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 38) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a carboxyl group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 39) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a carboxyl group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 40) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a sulfonic acid group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 41) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a sulfonic acid group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 42) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group, a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group, a 1,2-thiazole group, a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the 1,3,4-oxadiazole group, the 1,3,4-thiadiazole group, the 1,2,4-oxadiazole group, the 1,2,4-thiadiazole group, the 1,2,5-oxadiazole group, the 1,2,5-thiadiazole group, the 1,2-oxazole group, the 1,2-thiazole group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 43) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the quinolyl group and the isoquinolyl group are optionally substituted with an azole group optionally substituted with one or more hydroxyl groups (the azole group is a 1,3,4-oxadiazole group, a 1,3,4-thiadiazole group, a 1,2,4-oxadiazole group, a 1,2,4-thiadiazole group, a 1,2,5-oxadiazole group, a 1,2,5-thiadiazole group, a 1,2-oxazole group or a 1,2-thiazole group)), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 44) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more —CH2CO2H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 45) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —CH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 46) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group, (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —OCH2CO2H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 47) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —OCH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 48) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —NHCH2CO2H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 49) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —NHCH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 50) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with one or more —CH2CH2CO2H groups), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 51) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with one or more —CH2CH2CO2H groups, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 52) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with one or more substituents optionally selected from the group consisting of:
  • a carboxyl group, a phosphonic acid group, sulfonic acid group, a carbamido group, a sulfamido group, a hydroxycarbamido group, a hydroxysulfamido group and a tetrazole group
  • and a substituent optionally selected from the group consisting of:
  • a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 53) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more substituents selected from the group consisting of:
  • a carboxyl group, a phosphonic acid group, a sulfonic acid group and a tetrazole group
  • and one or more substituents optionally selected from the group consisting of:
  • a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 54) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group (the phenyl group is optionally substituted with one or more substituents selected from the group consisting of:
  • a carboxyl group, a phosphonic acid group, a sulfonic acid group and a tetrazole group
  • and one or more substituents optionally selected from the group consisting of:
  • a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two c1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 55) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a carboxyl group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 56) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a carboxyl group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 57) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a sulfonic acid group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 58) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a sulfonic acid group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 59) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a pyridyl group, a thienyl group, a furyl group, a pyridazinyl group; a quinolyl group or an isoquinolyl group (the phenyl group, the pyridyl group, the thienyl group, the furyl group, the pyridazinyl group, the quinolyl group and the isoquinolyl group are optionally substituted with one or more hydroxyl groups and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 60) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are optionally substituted with a —CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido is group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 61) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 62) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —OCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 63) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —OCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 64) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —NHCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 65) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —NHCH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 66) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group, a thienyl group, a furyl group, a pyridazinyl group, a pyridyl group, a quinolyl group or an isoquinolyl group (the phenyl group, the thienyl group, the furyl group, the pyridazinyl group, the pyridyl group, the quinolyl group and the isoquinolyl group are substituted with a —CH2CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 67) The compounds according to 28), 29) or 30) wherein R3 is a phenyl group substituted with a —CH2CH2CO2H group and a substituent optionally selected from a nitro group, a cyano group, a halogen atom, a C1-10 alkyl group substituted with one or more fluorine atoms, a sulfamido group substituted with one or two C1-10 alkyl groups, a carbamido group substituted with one or two C1-10 alkyl groups and a C1-10 alkylcarbonylamino group, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 68) The compounds wherein A, B, R1, L1, R, L2, L3, L4, R3 and X are any of the following combinations in Table 1, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 1 denote the flowing substituents.
  • Figure US20140051857A1-20140220-C00003
    Figure US20140051857A1-20140220-C00004
    Figure US20140051857A1-20140220-C00005
  • TABLE 1
    No A B R1 L1 R2 L2 L3 Y L4 R3 X
    1 N NMe Q1a a bond Me a bond NH S NH Q3a OH
    2 N NMe Q1a a bond Me a bond NH S NH Q3b OH
    3 N NMe Q1a a bond Me a bond NH S NH Q3c OH
    4 N NMe Q1a a bond Me a bond NH S a bond Q3a OH
    5 N NMe Q1a a bond Me a bond NH S a bond Q3b OH
    6 N NMe Q1a a bond Me a bond NH S a bond Q3c OH
    7 N NMe Q1a a bond Me a bond NH O NH Q3a OH
    8 N NMe Q1a a bond Me a bond NH O NH Q3b OH
    9 N NMe Q1a a bond Me a bond NH O NH Q3c OH
    10 N NMe Q1a a bond Me a bond NH O a bond Q3a OH
    11 N NMe Q1a a bond Me a bond NH O a bond Q3b OH
    12 N NMe Q1a a bond Me a bond NH O a bond Q3c OH
    13 N NMe Q1a a bond H a bond NH S NH Q3a OH
    14 N NMe Q1a a bond H a bond NH S NH Q3b OH
    15 N NMe Q1a a bond H a bond NH S NH Q3c OH
    16 N NMe Q1a a bond H a bond NH S a bond Q3a OH
    17 N NMe Q1a a bond H a bond NH S a bond Q3b OH
    18 N NMe Q1a a bond H a bond NH S a bond Q3c OH
    19 N NMe Q1a a bond H a bond NH O NH Q3a OH
    20 N NMe Q1a a bond H a bond NH O NH Q3b OH
    21 N NMe Q1a a bond H a bond NH O NH Q3c OH
    22 N NMe Q1a a bond H a bond NH O a bond Q3a OH
    23 N NMe Q1a a bond H a bond NH O a bond Q3b OH
    24 N NMe Q1a a bond H a bond NH O a bond Q3c OH
    25 N NMe Q1b a bond Me a bond NH S NH Q3a OH
    26 N NMe Q1b a bond Me a bond NH S NH Q3b OH
    27 N NMe Q1b a bond Me a bond NH S NH Q3c OH
    28 N NMe Q1b a bond Me a bond NH S a bond Q3a OH
    29 N NMe Q1b a bond Me a bond NH S a bond Q3b OH
    30 N NMe Q1b a bond Me a bond NH S a bond Q3c OH
    31 N NMe Q1b a bond Me a bond NH O NH Q3a OH
    32 N NMe Q1b a bond Me a bond NH O NH Q3b OH
    33 N NMe Q1b a bond Me a bond NH O NH Q3c OH
    34 N NMe Q1b a bond Me a bond NH O a bond Q3a OH
    35 N NMe Q1b a bond Me a bond NH O a bond Q3b OH
    36 N NMe Q1b a bond Me a bond NH O a bond Q3c OH
    37 N NMe Q1b a bond H a bond NH S NH Q3a OH
    38 N NMe Q1b a bond H a bond NH S NH Q3b OH
    39 N NMe Q1b a bond H a bond NH S NH Q3c OH
    40 N NMe Q1b a bond H a bond NH S a bond Q3a OH
    41 N NMe Q1b a bond H a bond NH S a bond Q3b OH
    42 N NMe Q1b a bond H a bond NH S a bond Q3c OH
    43 N NMe Q1b a bond H a bond NH O NH Q3a OH
    44 N NMe Q1b a bond H a bond NH O NH Q3b OH
    45 N NMe Q1b a bond H a bond NH O NH Q3c OH
    46 N NMe Q1b a bond H a bond NH O a bond Q3a OH
    47 N NMe Q1b a bond H a bond NH O a bond Q3b OH
    48 N NMe Q1b a bond H a bond NH O a bond Q3c OH
    49 N NMe Q1c a bond Me a bond NH S NH Q3a OH
    50 N NMe Q1c a bond Me a bond NH S NH Q3b OH
    51 N NMe Q1c a bond Me a bond NH S NH Q3c OH
    52 N NMe Q1c a bond Me a bond NH S a bond Q3a OH
    53 N NMe Q1c a bond Me a bond NH S a bond Q3b OH
    54 N NMe Q1c a bond Me a bond NH S a bond Q3c OH
    55 N NMe Q1c a bond Me a bond NH O NH Q3a OH
    56 N NMe Q1c a bond Me a bond NH O NH Q3b OH
    57 N NMe Q1c a bond Me a bond NH O NH Q3c OH
    58 N NMe Q1c a bond Me a bond NH O a bond Q3a OH
    59 N NMe Q1c a bond Me a bond NH O a bond Q3b OH
    60 N NMe Q1c a bond Me a bond NH O a bond Q3c OH
    61 N NMe Q1c a bond H a bond NH S NH Q3a OH
    62 N NMe Q1c a bond H a bond NH S NH Q3b OH
    63 N NMe Q1c a bond H a bond NH S NH Q3c OH
    64 N NMe Q1c a bond H a bond NH S a bond Q3a OH
    65 N NMe Q1c a bond H a bond NH S a bond Q3b OH
    66 N NMe Q1c a bond H a bond NH S a bond Q3c OH
    67 N NMe Q1c a bond H a bond NH O NH Q3a OH
    68 N NMe Q1c a bond H a bond NH O NH Q3b OH
    69 N NMe Q1c a bond H a bond NH O NH Q3c OH
    70 N NMe Q1c a bond H a bond NH O a bond Q3a OH
    71 N NMe Q1c a bond H a bond NH O a bond Q3b OH
    72 N NMe Q1c a bond H a bond NH O a bond Q3c OH
    73 N NMe Q1d a bond Me a bond NH S NH Q3a OH
    74 N NMe Q1d a bond Me a bond NH S NH Q3b OH
    75 N NMe Q1d a bond Me a bond NH S NH Q3c OH
    76 N NMe Q1d a bond Me a bond NH S a bond Q3a OH
    77 N NMe Q1d a bond Me a bond NH S a bond Q3b OH
    78 N NMe Q1d a bond Me a bond NH S a bond Q3c OH
    79 N NMe Q1d a bond Me a bond NH O NH Q3a OH
    80 N NMe Q1d a bond Me a bond NH O NH Q3b OH
    81 N NMe Q1d a bond Me a bond NH O NH Q3c OH
    82 N NMe Q1d a bond Me a bond NH O a bond Q3a OH
    83 N NMe Q1d a bond Me a bond NH O a bond Q3b OH
    84 N NMe Q1d a bond Me a bond NH O a bond Q3c OH
    85 N NMe Q1d a bond H a bond NH S NH Q3a OH
    86 N NMe Q1d a bond H a bond NH S NH Q3b OH
    87 N NMe Q1d a bond H a bond NH S NH Q3c OH
    88 N NMe Q1d a bond H a bond NH S a bond Q3a OH
    89 N NMe Q1d a bond H a bond NH S a bond Q3b OH
    90 N NMe Q1d a bond H a bond NH S a bond Q3c OH
    91 N NMe Q1d a bond H a bond NH O NH Q3a OH
    92 N NMe Q1d a bond H a bond NH O NH Q3b OH
    93 N NMe Q1d a bond H a bond NH O NH Q3c OH
    94 N NMe Q1d a bond H a bond NH O a bond Q3a OH
    95 N NMe Q1d a bond H a bond NH O a bond Q3b OH
    96 N NMe Q1d a bond H a bond NH O a bond Q3c OH
    97 N NMe Q1e a bond Me a bond NH S NH Q3a OH
    98 N NMe Q1e a bond Me a bond NH S NH Q3b OH
    99 N NMe Q1e a bond Me a bond NH S NH Q3c OH
    100 N NMe Q1e a bond Me a bond NH S a bond Q3a OH
    101 N NMe Q1e a bond Me a bond NH S a bond Q3b OH
    102 N NMe Q1e a bond Me a bond NH S a bond Q3c OH
    103 N NMe Q1e a bond Me a bond NH O NH Q3a OH
    104 N NMe Q1e a bond Me a bond NH O NH Q3b OH
    105 N NMe Q1e a bond Me a bond NH O NH Q3c OH
    106 N NMe Q1e a bond Me a bond NH O a bond Q3a OH
    107 N NMe Q1e a bond Me a bond NH O a bond Q3b OH
    108 N NMe Q1e a bond Me a bond NH O a bond Q3c OH
    109 N NMe Q1e a bond H a bond NH S NH Q3a OH
    110 N NMe Q1e a bond H a bond NH S NH Q3b OH
    111 N NMe Q1e a bond H a bond NH S NH Q3c OH
    112 N NMe Q1e a bond H a bond NH S a bond Q3a OH
    113 N NMe Q1e a bond H a bond NH S a bond Q3b OH
    114 N NMe Q1e a bond H a bond NH S a bond Q3c OH
    115 N NMe Q1e a bond H a bond NH O NH Q3a OH
    116 N NMe Q1e a bond H a bond NH O NH Q3b OH
    117 N NMe Q1e a bond H a bond NH O NH Q3c OH
    118 N NMe Q1e a bond H a bond NH O a bond Q3a OH
    119 N NMe Q1e a bond H a bond NH O a bond Q3b OH
    120 N NMe Q1e a bond H a bond NH O a bond Q3c OH
    121 N NMe Q1f a bond Me a bond NH S NH Q3a OH
    122 N NMe Q1f a bond Me a bond NH S NH Q3b OH
    123 N NMe Q1f a bond Me a bond NH S NH Q3c OH
    124 N NMe Q1f a bond Me a bond NH S a bond Q3a OH
    125 N NMe Q1f a bond Me a bond NH S a bond Q3b OH
    126 N NMe Q1f a bond Me a bond NH S a bond Q3c OH
    127 N NMe Q1f a bond Me a bond NH O NH Q3a OH
    128 N NMe Q1f a bond Me a bond NH O NH Q3b OH
    129 N NMe Q1f a bond Me a bond NH O NH Q3c OH
    130 N NMe Q1f a bond Me a bond NH O a bond Q3a OH
    131 N NMe Q1f a bond Me a bond NH O a bond Q3b OH
    132 N NMe Q1f a bond Me a bond NH O a bond Q3c OH
    133 N NMe Q1f a bond H a bond NH S NH Q3a OH
    134 N NMe Q1f a bond H a bond NH S NH Q3b OH
    135 N NMe Q1f a bond H a bond NH S NH Q3c OH
    136 N NMe Q1f a bond H a bond NH S a bond Q3a OH
    137 N NMe Q1f a bond H a bond NH S a bond Q3b OH
    138 N NMe Q1f a bond H a bond NH S a bond Q3c OH
    139 N NMe Q1f a bond H a bond NH O NH Q3a OH
    140 N NMe Q1f a bond H a bond NH O NH Q3b OH
    141 N NMe Q1f a bond H a bond NH O NH Q3c OH
    142 N NMe Q1f a bond H a bond NH O a bond Q3a OH
    143 N NMe Q1f a bond H a bond NH O a bond Q3b OH
    144 N NMe Q1f a bond H a bond NH O a bond Q3c OH
    145 N NMe Q1g a bond Me a bond NH S NH Q3a OH
    146 N NMe Q1g a bond Me a bond NH S NH Q3b OH
    147 N NMe Q1g a bond Me a bond NH S NH Q3c OH
    148 N NMe Q1g a bond Me a bond NH S a bond Q3a OH
    149 N NMe Q1g a bond Me a bond NH S a bond Q3b OH
    150 N NMe Q1g a bond Me a bond NH S a bond Q3c OH
    151 N NMe Q1g a bond Me a bond NH O NH Q3a OH
    152 N NMe Q1g a bond Me a bond NH O NH Q3b OH
    153 N NMe Q1g a bond Me a bond NH O NH Q3c OH
    154 N NMe Q1g a bond Me a bond NH O a bond Q3a OH
    155 N NMe Q1g a bond Me a bond NH O a bond Q3b OH
    156 N NMe Q1g a bond Me a bond NH O a bond Q3c OH
    157 N NMe Q1g a bond H a bond NH S NH Q3a OH
    158 N NMe Q1g a bond H a bond NH S NH Q3b OH
    159 N NMe Q1g a bond H a bond NH S NH Q3c OH
    160 N NMe Q1g a bond H a bond NH S a bond Q3a OH
    161 N NMe Q1g a bond H a bond NH S a bond Q3b OH
    162 N NMe Q1g a bond H a bond NH S a bond Q3c OH
    163 N NMe Q1g a bond H a bond NH O NH Q3a OH
    164 N NMe Q1g a bond H a bond NH O NH Q3b OH
    165 N NMe Q1g a bond H a bond NH O NH Q3c OH
    166 N NMe Q1g a bond H a bond NH O a bond Q3a OH
    167 N NMe Q1g a bond H a bond NH O a bond Q3b OH
    168 N NMe Q1g a bond H a bond NH O a bond Q3c OH
    169 N NMe Q1h a bond Me a bond NH S NH Q3a OH
    170 N NMe Q1h a bond Me a bond NH S NH Q3b OH
    171 N NMe Q1h a bond Me a bond NH S NH Q3c OH
    172 N NMe Q1h a bond Me a bond NH S a bond Q3a OH
    173 N NMe Q1h a bond Me a bond NH S a bond Q3b OH
    174 N NMe Q1h a bond Me a bond NH S a bond Q3c OH
    175 N NMe Q1h a bond Me a bond NH O NH Q3a OH
    176 N NMe Q1h a bond Me a bond NH O NH Q3b OH
    177 N NMe Q1h a bond Me a bond NH O NH Q3c OH
    178 N NMe Q1h a bond Me a bond NH O a bond Q3a OH
    179 N NMe Q1h a bond Me a bond NH O a bond Q3b OH
    180 N NMe Q1h a bond Me a bond NH O a bond Q3c OH
    181 N NMe Q1h a bond H a bond NH S NH Q3a OH
    182 N NMe Q1h a bond H a bond NH S NH Q3b OH
    183 N NMe Q1h a bond H a bond NH S NH Q3c OH
    184 N NMe Q1h a bond H a bond NH S a bond Q3a OH
    185 N NMe Q1h a bond H a bond NH S a bond Q3b OH
    186 N NMe Q1h a bond H a bond NH S a bond Q3c OH
    187 N NMe Q1h a bond H a bond NH O NH Q3a OH
    188 N NMe Q1h a bond H a bond NH O NH Q3b OH
    189 N NMe Q1h a bond H a bond NH O NH Q3c OH
    190 N NMe Q1h a bond H a bond NH O a bond Q3a OH
    191 N NMe Q1h a bond H a bond NH O a bond Q3b OH
    192 N NMe Q1h a bond H a bond NH O a bond Q3c OH
    193 N NMe Q1i a bond Me a bond NH S NH Q3a OH
    194 N NMe Q1i a bond Me a bond NH S NH Q3b OH
    195 N NMe Q1i a bond Me a bond NH S NH Q3c OH
    196 N NMe Q1i a bond Me a bond NH S a bond Q3a OH
    197 N NMe Q1i a bond Me a bond NH S a bond Q3b OH
    198 N NMe Q1i a bond Me a bond NH S a bond Q3c OH
    199 N NMe Q1i a bond Me a bond NH O NH Q3a OH
    200 N NMe Q1i a bond Me a bond NH O NH Q3b OH
    201 N NMe Q1i a bond Me a bond NH O NH Q3c OH
    202 N NMe Q1i a bond Me a bond NH O a bond Q3a OH
    203 N NMe Q1i a bond Me a bond NH O a bond Q3b OH
    204 N NMe Q1i a bond Me a bond NH O a bond Q3c OH
    205 N NMe Q1i a bond H a bond NH S NH Q3a OH
    206 N NMe Q1i a bond H a bond NH S NH Q3b OH
    207 N NMe Q1i a bond H a bond NH S NH Q3c OH
    208 N NMe Q1i a bond H a bond NH S a bond Q3a OH
    209 N NMe Q1i a bond H a bond NH S a bond Q3b OH
    210 N NMe Q1i a bond H a bond NH S a bond Q3c OH
    211 N NMe Q1i a bond H a bond NH O NH Q3a OH
    212 N NMe Q1i a bond H a bond NH O NH Q3b OH
    213 N NMe Q1i a bond H a bond NH O NH Q3c OH
    214 N NMe Q1i a bond H a bond NH O a bond Q3a OH
    215 N NMe Q1i a bond H a bond NH O a bond Q3b OH
    216 N NMe Q1i a bond H a bond NH O a bond Q3c OH
    217 N NMe Q1j a bond Me a bond NH S NH Q3a OH
    218 N NMe Q1j a bond Me a bond NH S NH Q3b OH
    219 N NMe Q1j a bond Me a bond NH S NH Q3c OH
    220 N NMe Q1j a bond Me a bond NH S a bond Q3a OH
    221 N NMe Q1j a bond Me a bond NH S a bond Q3b OH
    222 N NMe Q1j a bond Me a bond NH S a bond Q3c OH
    223 N NMe Q1j a bond Me a bond NH O NH Q3a OH
    224 N NMe Q1j a bond Me a bond NH O NH Q3b OH
    225 N NMe Q1j a bond Me a bond NH O NH Q3c OH
    226 N NMe Q1j a bond Me a bond NH O a bond Q3a OH
    227 N NMe Q1j a bond Me a bond NH O a bond Q3b OH
    228 N NMe Q1j a bond Me a bond NH O a bond Q3c OH
    229 N NMe Q1j a bond H a bond NH S NH Q3a OH
    230 N NMe Q1j a bond H a bond NH S NH Q3b OH
    231 N NMe Q1j a bond H a bond NH S NH Q3c OH
    232 N NMe Q1j a bond H a bond NH S a bond Q3a OH
    233 N NMe Q1j a bond H a bond NH S a bond Q3b OH
    234 N NMe Q1j a bond H a bond NH S a bond Q3c OH
    235 N NMe Q1j a bond H a bond NH O NH Q3a OH
    236 N NMe Q1j a bond H a bond NH O NH Q3b OH
    237 N NMe Q1j a bond H a bond NH O NH Q3c OH
    238 N NMe Q1j a bond H a bond NH O a bond Q3a OH
    239 N NMe Q1j a bond H a bond NH O a bond Q3b OH
    240 N NMe Q1j a bond H a bond NH O a bond Q3c OH
    241 N NEt Q1a a bond Me a bond NH S NH Q3a OH
    242 N NEt Q1a a bond Me a bond NH S NH Q3b OH
    243 N NEt Q1a a bond Me a bond NH S NH Q3c OH
    244 N NEt Q1a a bond Me a bond NH S a bond Q3a OH
    245 N NEt Q1a a bond Me a bond NH S a bond Q3b OH
    246 N NEt Q1a a bond Me a bond NH S a bond Q3c OH
    247 N NEt Q1a a bond Me a bond NH O NH Q3a OH
    248 N NEt Q1a a bond Me a bond NH O NH Q3b OH
    249 N NEt Q1a a bond Me a bond NH O NH Q3c OH
    250 N NEt Q1a a bond Me a bond NH O a bond Q3a OH
    251 N NEt Q1a a bond Me a bond NH O a bond Q3b OH
    252 N NEt Q1a a bond Me a bond NH O a bond Q3c OH
    253 N NEt Q1a a bond H a bond NH S NH Q3a OH
    254 N NEt Q1a a bond H a bond NH S NH Q3b OH
    255 N NEt Q1a a bond H a bond NH S NH Q3c OH
    256 N NEt Q1a a bond H a bond NH S a bond Q3a OH
    257 N NEt Q1a a bond H a bond NH S a bond Q3b OH
    258 N NEt Q1a a bond H a bond NH S a bond Q3c OH
    259 N NEt Q1a a bond H a bond NH O NH Q3a OH
    260 N NEt Q1a a bond H a bond NH O NH Q3b OH
    261 N NEt Q1a a bond H a bond NH O NH Q3c OH
    262 N NEt Q1a a bond H a bond NH O a bond Q3a OH
    263 N NEt Q1a a bond H a bond NH O a bond Q3b OH
    264 N NEt Q1a a bond H a bond NH O a bond Q3c OH
    265 N NEt Q1b a bond Me a bond NH S NH Q3a OH
    266 N NEt Q1b a bond Me a bond NH S NH Q3b OH
    267 N NEt Q1b a bond Me a bond NH S NH Q3c OH
    268 N NEt Q1b a bond Me a bond NH S a bond Q3a OH
    269 N NEt Q1b a bond Me a bond NH S a bond Q3b OH
    270 N NEt Q1b a bond Me a bond NH S a bond Q3c OH
    271 N NEt Q1b a bond Me a bond NH O NH Q3a OH
    272 N NEt Q1b a bond Me a bond NH O NH Q3b OH
    273 N NEt Q1b a bond Me a bond NH O NH Q3c OH
    274 N NEt Q1b a bond Me a bond NH O a bond Q3a OH
    275 N NEt Q1b a bond Me a bond NH O a bond Q3b OH
    276 N NEt Q1b a bond Me a bond NH O a bond Q3c OH
    277 N NEt Q1b a bond H a bond NH S NH Q3a OH
    278 N NEt Q1b a bond H a bond NH S NH Q3b OH
    279 N NEt Q1b a bond H a bond NH S NH Q3c OH
    280 N NEt Q1b a bond H a bond NH S a bond Q3a OH
    281 N NEt Q1b a bond H a bond NH S a bond Q3b OH
    282 N NEt Q1b a bond H a bond NH S a bond Q3c OH
    283 N NEt Q1b a bond H a bond NH O NH Q3a OH
    284 N NEt Q1b a bond H a bond NH O NH Q3b OH
    285 N NEt Q1b a bond H a bond NH O NH Q3c OH
    286 N NEt Q1b a bond H a bond NH O a bond Q3a OH
    287 N NEt Q1b a bond H a bond NH O a bond Q3b OH
    288 N NEt Q1b a bond H a bond NH O a bond Q3c OH
    289 N NEt Q1c a bond Me a bond NH S NH Q3a OH
    290 N NEt Q1c a bond Me a bond NH S NH Q3b OH
    291 N NEt Q1c a bond Me a bond NH S NH Q3c OH
    292 N NEt Q1c a bond Me a bond NH S a bond Q3a OH
    293 N NEt Q1c a bond Me a bond NH S a bond Q3b OH
    294 N NEt Q1c a bond Me a bond NH S a bond Q3c OH
    295 N NEt Q1c a bond Me a bond NH O NH Q3a OH
    296 N NEt Q1c a bond Me a bond NH O NH Q3b OH
    297 N NEt Q1c a bond Me a bond NH O NH Q3c OH
    298 N NEt Q1c a bond Me a bond NH O a bond Q3a OH
    299 N NEt Q1c a bond Me a bond NH O a bond Q3b OH
    300 N NEt Q1c a bond Me a bond NH O a bond Q3c OH
    301 N NEt Q1c a bond H a bond NH S NH Q3a OH
    302 N NEt Q1c a bond H a bond NH S NH Q3b OH
    303 N NEt Q1c a bond H a bond NH S NH Q3c OH
    304 N NEt Q1c a bond H a bond NH S a bond Q3a OH
    305 N NEt Q1c a bond H a bond NH S a bond Q3b OH
    306 N NEt Q1c a bond H a bond NH S a bond Q3c OH
    307 N NEt Q1c a bond H a bond NH O NH Q3a OH
    308 N NEt Q1c a bond H a bond NH O NH Q3b OH
    309 N NEt Q1c a bond H a bond NH O NH Q3c OH
    310 N NEt Q1c a bond H a bond NH O a bond Q3a OH
    311 N NEt Q1c a bond H a bond NH O a bond Q3b OH
    312 N NEt Q1c a bond H a bond NH O a bond Q3c OH
    313 N NEt Q1d a bond Me a bond NH S NH Q3a OH
    314 N NEt Q1d a bond Me a bond NH S NH Q3b OH
    315 N NEt Q1d a bond Me a bond NH S NH Q3c OH
    316 N NEt Q1d a bond Me a bond NH S a bond Q3a OH
    317 N NEt Q1d a bond Me a bond NH S a bond Q3b OH
    318 N NEt Q1d a bond Me a bond NH S a bond Q3c OH
    319 N NEt Q1d a bond Me a bond NH O NH Q3a OH
    320 N NEt Q1d a bond Me a bond NH O NH Q3b OH
    321 N NEt Q1d a bond Me a bond NH O NH Q3c OH
    322 N NEt Q1d a bond Me a bond NH O a bond Q3a OH
    323 N NEt Q1d a bond Me a bond NH O a bond Q3b OH
    324 N NEt Q1d a bond Me a bond NH O a bond Q3c OH
    325 N NEt Q1d a bond H a bond NH S NH Q3a OH
    326 N NEt Q1d a bond H a bond NH S NH Q3b OH
    327 N NEt Q1d a bond H a bond NH S NH Q3c OH
    328 N NEt Q1d a bond H a bond NH S a bond Q3a OH
    329 N NEt Q1d a bond H a bond NH S a bond Q3b OH
    330 N NEt Q1d a bond H a bond NH S a bond Q3c OH
    331 N NEt Q1d a bond H a bond NH O NH Q3a OH
    332 N NEt Q1d a bond H a bond NH O NH Q3b OH
    333 N NEt Q1d a bond H a bond NH O NH Q3c OH
    334 N NEt Q1d a bond H a bond NH O a bond Q3a OH
    335 N NEt Q1d a bond H a bond NH O a bond Q3b OH
    336 N NEt Q1d a bond H a bond NH O a bond Q3c OH
    337 N NEt Q1e a bond Me a bond NH S NH Q3a OH
    338 N NEt Q1e a bond Me a bond NH S NH Q3b OH
    339 N NEt Q1e a bond Me a bond NH S NH Q3c OH
    340 N NEt Q1e a bond Me a bond NH S a bond Q3a OH
    341 N NEt Q1e a bond Me a bond NH S a bond Q3b OH
    342 N NEt Q1e a bond Me a bond NH S a bond Q3c OH
    343 N NEt Q1e a bond Me a bond NH O NH Q3a OH
    344 N NEt Q1e a bond Me a bond NH O NH Q3b OH
    345 N NEt Q1e a bond Me a bond NH O NH Q3c OH
    346 N NEt Q1e a bond Me a bond NH O a bond Q3a OH
    347 N NEt Q1e a bond Me a bond NH O a bond Q3b OH
    348 N NEt Q1e a bond Me a bond NH O a bond Q3c OH
    349 N NEt Q1e a bond H a bond NH S NH Q3a OH
    350 N NEt Q1e a bond H a bond NH S NH Q3b OH
    351 N NEt Q1e a bond H a bond NH S NH Q3c OH
    352 N NEt Q1e a bond H a bond NH S a bond Q3a OH
    353 N NEt Q1e a bond H a bond NH S a bond Q3b OH
    354 N NEt Q1e a bond H a bond NH S a bond Q3c OH
    355 N NEt Q1e a bond H a bond NH O NH Q3a OH
    356 N NEt Q1e a bond H a bond NH O NH Q3b OH
    357 N NEt Q1e a bond H a bond NH O NH Q3c OH
    358 N NEt Q1e a bond H a bond NH O a bond Q3a OH
    359 N NEt Q1e a bond H a bond NH O a bond Q3b OH
    360 N NEt Q1e a bond H a bond NH O a bond Q3c OH
    361 N NEt Q1f a bond Me a bond NH S NH Q3a OH
    362 N NEt Q1f a bond Me a bond NH S NH Q3b OH
    363 N NEt Q1f a bond Me a bond NH S NH Q3c OH
    364 N NEt Q1f a bond Me a bond NH S a bond Q3a OH
    365 N NEt Q1f a bond Me a bond NH S a bond Q3b OH
    366 N NEt Q1f a bond Me a bond NH S a bond Q3c OH
    367 N NEt Q1f a bond Me a bond NH O NH Q3a OH
    368 N NEt Q1f a bond Me a bond NH O NH Q3b OH
    369 N NEt Q1f a bond Me a bond NH O NH Q3c OH
    370 N NEt Q1f a bond Me a bond NH O a bond Q3a OH
    371 N NEt Q1f a bond Me a bond NH O a bond Q3b OH
    372 N NEt Q1f a bond Me a bond NH O a bond Q3c OH
    373 N NEt Q1f a bond H a bond NH S NH Q3a OH
    374 N NEt Q1f a bond H a bond NH S NH Q3b OH
    375 N NEt Q1f a bond H a bond NH S NH Q3c OH
    376 N NEt Q1f a bond H a bond NH S a bond Q3a OH
    377 N NEt Q1f a bond H a bond NH S a bond Q3b OH
    378 N NEt Q1f a bond H a bond NH S a bond Q3c OH
    379 N NEt Q1f a bond H a bond NH O NH Q3a OH
    380 N NEt Q1f a bond H a bond NH O NH Q3b OH
    381 N NEt Q1f a bond H a bond NH O NH Q3c OH
    382 N NEt Q1f a bond H a bond NH O a bond Q3a OH
    383 N NEt Q1f a bond H a bond NH O a bond Q3b OH
    384 N NEt Q1f a bond H a bond NH O a bond Q3c OH
    385 N NEt Q1g a bond Me a bond NH S NH Q3a OH
    386 N NEt Q1g a bond Me a bond NH S NH Q3b OH
    387 N NEt Q1g a bond Me a bond NH S NH Q3c OH
    388 N NEt Q1g a bond Me a bond NH S a bond Q3a OH
    389 N NEt Q1g a bond Me a bond NH S a bond Q3b OH
    390 N NEt Q1g a bond Me a bond NH S a bond Q3c OH
    391 N NEt Q1g a bond Me a bond NH O NH Q3a OH
    392 N NEt Q1g a bond Me a bond NH O NH Q3b OH
    393 N NEt Q1g a bond Me a bond NH O NH Q3c OH
    394 N NEt Q1g a bond Me a bond NH O a bond Q3a OH
    395 N NEt Q1g a bond Me a bond NH O a bond Q3b OH
    396 N NEt Q1g a bond Me a bond NH O a bond Q3c OH
    397 N NEt Q1g a bond H a bond NH S NH Q3a OH
    398 N NEt Q1g a bond H a bond NH S NH Q3b OH
    399 N NEt Q1g a bond H a bond NH S NH Q3c OH
    400 N NEt Q1g a bond H a bond NH S a bond Q3a OH
    401 N NEt Q1g a bond H a bond NH S a bond Q3b OH
    402 N NEt Q1g a bond H a bond NH S a bond Q3c OH
    403 N NEt Q1g a bond H a bond NH O NH Q3a OH
    404 N NEt Q1g a bond H a bond NH O NH Q3b OH
    405 N NEt Q1g a bond H a bond NH O NH Q3c OH
    406 N NEt Q1g a bond H a bond NH O a bond Q3a OH
    407 N NEt Q1g a bond H a bond NH O a bond Q3b OH
    408 N NEt Q1g a bond H a bond NH O a bond Q3c OH
    409 N NEt Q1h a bond Me a bond NH S NH Q3a OH
    410 N NEt Q1h a bond Me a bond NH S NH Q3b OH
    411 N NEt Q1h a bond Me a bond NH S NH Q3c OH
    412 N NEt Q1h a bond Me a bond NH S a bond Q3a OH
    413 N NEt Q1h a bond Me a bond NH S a bond Q3b OH
    414 N NEt Q1h a bond Me a bond NH S a bond Q3c OH
    415 N NEt Q1h a bond Me a bond NH O NH Q3a OH
    416 N NEt Q1h a bond Me a bond NH O NH Q3b OH
    417 N NEt Q1h a bond Me a bond NH O NH Q3c OH
    418 N NEt Q1h a bond Me a bond NH O a bond Q3a OH
    419 N NEt Q1h a bond Me a bond NH O a bond Q3b OH
    420 N NEt Q1h a bond Me a bond NH O a bond Q3c OH
    421 N NEt Q1h a bond H a bond NH S NH Q3a OH
    422 N NEt Q1h a bond H a bond NH S NH Q3b OH
    423 N NEt Q1h a bond H a bond NH S NH Q3c OH
    424 N NEt Q1h a bond H a bond NH S a bond Q3a OH
    425 N NEt Q1h a bond H a bond NH S a bond Q3b OH
    426 N NEt Q1h a bond H a bond NH S a bond Q3c OH
    427 N NEt Q1h a bond H a bond NH O NH Q3a OH
    428 N NEt Q1h a bond H a bond NH O NH Q3b OH
    429 N NEt Q1h a bond H a bond NH O NH Q3c OH
    430 N NEt Q1h a bond H a bond NH O a bond Q3a OH
    431 N NEt Q1h a bond H a bond NH O a bond Q3b OH
    432 N NEt Q1h a bond H a bond NH O a bond Q3c OH
    433 N NEt Q1i a bond Me a bond NH S NH Q3a OH
    434 N NEt Q1i a bond Me a bond NH S NH Q3b OH
    435 N NEt Q1i a bond Me a bond NH S NH Q3c OH
    436 N NEt Q1i a bond Me a bond NH S a bond Q3a OH
    437 N NEt Q1i a bond Me a bond NH S a bond Q3b OH
    438 N NEt Q1i a bond Me a bond NH S a bond Q3c OH
    439 N NEt Q1i a bond Me a bond NH O NH Q3a OH
    440 N NEt Q1i a bond Me a bond NH O NH Q3b OH
    441 N NEt Q1i a bond Me a bond NH O NH Q3c OH
    442 N NEt Q1i a bond Me a bond NH O a bond Q3a OH
    443 N NEt Q1i a bond Me a bond NH O a bond Q3b OH
    444 N NEt Q1i a bond Me a bond NH O a bond Q3c OH
    445 N NEt Q1i a bond H a bond NH S NH Q3a OH
    446 N NEt Q1i a bond H a bond NH S NH Q3b OH
    447 N NEt Q1i a bond H a bond NH S NH Q3c OH
    448 N NEt Q1i a bond H a bond NH S a bond Q3a OH
    449 N NEt Q1i a bond H a bond NH S a bond Q3b OH
    450 N NEt Q1i a bond H a bond NH S a bond Q3c OH
    451 N NEt Q1i a bond H a bond NH O NH Q3a OH
    452 N NEt Q1i a bond H a bond NH O NH Q3b OH
    453 N NEt Q1i a bond H a bond NH O NH Q3c OH
    454 N NEt Q1i a bond H a bond NH O a bond Q3a OH
    455 N NEt Q1i a bond H a bond NH O a bond Q3b OH
    456 N NEt Q1i a bond H a bond NH O a bond Q3c OH
    457 N NEt Q1j a bond Me a bond NH S NH Q3a OH
    458 N NEt Q1j a bond Me a bond NH S NH Q3b OH
    459 N NEt Q1j a bond Me a bond NH S NH Q3c OH
    460 N NEt Q1j a bond Me a bond NH S a bond Q3a OH
    461 N NEt Q1j a bond Me a bond NH S a bond Q3b OH
    462 N NEt Q1j a bond Me a bond NH S a bond Q3c OH
    463 N NEt Q1j a bond Me a bond NH O NH Q3a OH
    464 N NEt Q1j a bond Me a bond NH O NH Q3b OH
    465 N NEt Q1j a bond Me a bond NH O NH Q3c OH
    466 N NEt Q1j a bond Me a bond NH O a bond Q3a OH
    467 N NEt Q1j a bond Me a bond NH O a bond Q3b OH
    468 N NEt Q1j a bond Me a bond NH O a bond Q3c OH
    469 N NEt Q1j a bond H a bond NH S NH Q3a OH
    470 N NEt Q1j a bond H a bond NH S NH Q3b OH
    471 N NEt Q1j a bond H a bond NH S NH Q3c OH
    472 N NEt Q1j a bond H a bond NH S a bond Q3a OH
    473 N NEt Q1j a bond H a bond NH S a bond Q3b OH
    474 N NEt Q1j a bond H a bond NH S a bond Q3c OH
    475 N NEt Q1j a bond H a bond NH O NH Q3a OH
    476 N NEt Q1j a bond H a bond NH O NH Q3b OH
    477 N NEt Q1j a bond H a bond NH O NH Q3c OH
    478 N NEt Q1j a bond H a bond NH O a bond Q3a OH
    479 N NEt Q1j a bond H a bond NH O a bond Q3b OH
    480 N NEt Q1j a bond H a bond NH O a bond Q3c OH
    481 N S Q1a a bond Me a bond NH S NH Q3a OH
    482 N S Q1a a bond Me a bond NH S NH Q3b OH
    483 N S Q1a a bond Me a bond NH S NH Q3c OH
    484 N S Q1a a bond Me a bond NH S a bond Q3a OH
    485 N S Q1a a bond Me a bond NH S a bond Q3b OH
    486 N S Q1a a bond Me a bond NH S a bond Q3c OH
    487 N S Q1a a bond Me a bond NH O NH Q3a OH
    488 N S Q1a a bond Me a bond NH O NH Q3b OH
    489 N S Q1a a bond Me a bond NH O NH Q3c OH
    490 N S Q1a a bond Me a bond NH O a bond Q3a OH
    491 N S Q1a a bond Me a bond NH O a bond Q3b OH
    492 N S Q1a a bond Me a bond NH O a bond Q3c OH
    493 N S Q1a a bond H a bond NH S NH Q3a OH
    494 N S Q1a a bond H a bond NH S NH Q3b OH
    495 N S Q1a a bond H a bond NH S NH Q3c OH
    496 N S Q1a a bond H a bond NH S a bond Q3a OH
    497 N S Q1a a bond H a bond NH S a bond Q3b OH
    498 N S Q1a a bond H a bond NH S a bond Q3c OH
    499 N S Q1a a bond H a bond NH O NH Q3a OH
    500 N S Q1a a bond H a bond NH O NH Q3b OH
    501 N S Q1a a bond H a bond NH O NH Q3c OH
    502 N S Q1a a bond H a bond NH O a bond Q3a OH
    503 N S Q1a a bond H a bond NH O a bond Q3b OH
    504 N S Q1a a bond H a bond NH O a bond Q3c OH
    505 N S Q1b a bond Me a bond NH S NH Q3a OH
    506 N S Q1b a bond Me a bond NH S NH Q3b OH
    507 N S Q1b a bond Me a bond NH S NH Q3c OH
    508 N S Q1b a bond Me a bond NH S a bond Q3a OH
    509 N S Q1b a bond Me a bond NH S a bond Q3b OH
    510 N S Q1b a bond Me a bond NH S a bond Q3c OH
    511 N S Q1b a bond Me a bond NH O NH Q3a OH
    512 N S Q1b a bond Me a bond NH O NH Q3b OH
    513 N S Q1b a bond Me a bond NH O NH Q3c OH
    514 N S Q1b a bond Me a bond NH O a bond Q3a OH
    515 N S Q1b a bond Me a bond NH O a bond Q3b OH
    516 N S Q1b a bond Me a bond NH O a bond Q3c OH
    517 N S Q1b a bond H a bond NH S NH Q3a OH
    518 N S Q1b a bond H a bond NH S NH Q3b OH
    519 N S Q1b a bond H a bond NH S NH Q3c OH
    520 N S Q1b a bond H a bond NH S a bond Q3a OH
    521 N S Q1b a bond H a bond NH S a bond Q3b OH
    522 N S Q1b a bond H a bond NH S a bond Q3c OH
    523 N S Q1b a bond H a bond NH O NH Q3a OH
    524 N S Q1b a bond H a bond NH O NH Q3b OH
    525 N S Q1b a bond H a bond NH O NH Q3c OH
    526 N S Q1b a bond H a bond NH O a bond Q3a OH
    527 N S Q1b a bond H a bond NH O a bond Q3b OH
    528 N S Q1b a bond H a bond NH O a bond Q3c OH
    529 N S Q1c a bond Me a bond NH S NH Q3a OH
    530 N S Q1c a bond Me a bond NH S NH Q3b OH
    531 N S Q1c a bond Me a bond NH S NH Q3c OH
    532 N S Q1c a bond Me a bond NH S a bond Q3a OH
    533 N S Q1c a bond Me a bond NH S a bond Q3b OH
    534 N S Q1c a bond Me a bond NH S a bond Q3c OH
    535 N S Q1c a bond Me a bond NH O NH Q3a OH
    536 N S Q1c a bond Me a bond NH O NH Q3b OH
    537 N S Q1c a bond Me a bond NH O NH Q3c OH
    538 N S Q1c a bond Me a bond NH O a bond Q3a OH
    539 N S Q1c a bond Me a bond NH O a bond Q3b OH
    540 N S Q1c a bond Me a bond NH O a bond Q3c OH
    541 N S Q1c a bond H a bond NH S NH Q3a OH
    542 N S Q1c a bond H a bond NH S NH Q3b OH
    543 N S Q1c a bond H a bond NH S NH Q3c OH
    544 N S Q1c a bond H a bond NH S a bond Q3a OH
    545 N S Q1c a bond H a bond NH S a bond Q3b OH
    546 N S Q1c a bond H a bond NH S a bond Q3c OH
    547 N S Q1c a bond H a bond NH O NH Q3a OH
    548 N S Q1c a bond H a bond NH O NH Q3b OH
    549 N S Q1c a bond H a bond NH O NH Q3c OH
    550 N S Q1c a bond H a bond NH O a bond Q3a OH
    551 N S Q1c a bond H a bond NH O a bond Q3b OH
    552 N S Q1c a bond H a bond NH O a bond Q3c OH
    553 N S Q1d a bond Me a bond NH S NH Q3a OH
    554 N S Q1d a bond Me a bond NH S NH Q3b OH
    555 N S Q1d a bond Me a bond NH S NH Q3c OH
    556 N S Q1d a bond Me a bond NH S a bond Q3a OH
    557 N S Q1d a bond Me a bond NH S a bond Q3b OH
    558 N S Q1d a bond Me a bond NH S a bond Q3c OH
    559 N S Q1d a bond Me a bond NH O NH Q3a OH
    560 N S Q1d a bond Me a bond NH O NH Q3b OH
    561 N S Q1d a bond Me a bond NH O NH Q3c OH
    562 N S Q1d a bond Me a bond NH O a bond Q3a OH
    563 N S Q1d a bond Me a bond NH O a bond Q3b OH
    564 N S Q1d a bond Me a bond NH O a bond Q3c OH
    565 N S Q1d a bond H a bond NH S NH Q3a OH
    566 N S Q1d a bond H a bond NH S NH Q3b OH
    567 N S Q1d a bond H a bond NH S NH Q3c OH
    568 N S Q1d a bond H a bond NH S a bond Q3a OH
    569 N S Q1d a bond H a bond NH S a bond Q3b OH
    570 N S Q1d a bond H a bond NH S a bond Q3c OH
    571 N S Q1d a bond H a bond NH O NH Q3a OH
    572 N S Q1d a bond H a bond NH O NH Q3b OH
    573 N S Q1d a bond H a bond NH O NH Q3c OH
    574 N S Q1d a bond H a bond NH O a bond Q3a OH
    575 N S Q1d a bond H a bond NH O a bond Q3b OH
    576 N S Q1d a bond H a bond NH O a bond Q3c OH
    577 N S Q1e a bond Me a bond NH S NH Q3a OH
    578 N S Q1e a bond Me a bond NH S NH Q3b OH
    579 N S Q1e a bond Me a bond NH S NH Q3c OH
    580 N S Q1e a bond Me a bond NH S a bond Q3a OH
    581 N S Q1e a bond Me a bond NH S a bond Q3b OH
    582 N S Q1e a bond Me a bond NH S a bond Q3c OH
    583 N S Q1e a bond Me a bond NH O NH Q3a OH
    584 N S Q1e a bond Me a bond NH O NH Q3b OH
    585 N S Q1e a bond Me a bond NH O NH Q3c OH
    586 N S Q1e a bond Me a bond NH O a bond Q3a OH
    587 N S Q1e a bond Me a bond NH O a bond Q3b OH
    588 N S Q1e a bond Me a bond NH O a bond Q3c OH
    589 N S Q1e a bond H a bond NH S NH Q3a OH
    590 N S Q1e a bond H a bond NH S NH Q3b OH
    591 N S Q1e a bond H a bond NH S NH Q3c OH
    592 N S Q1e a bond H a bond NH S a bond Q3a OH
    593 N S Q1e a bond H a bond NH S a bond Q3b OH
    594 N S Q1e a bond H a bond NH S a bond Q3c OH
    595 N S Q1e a bond H a bond NH O NH Q3a OH
    596 N S Q1e a bond H a bond NH O NH Q3b OH
    597 N S Q1e a bond H a bond NH O NH Q3c OH
    598 N S Q1e a bond H a bond NH O a bond Q3a OH
    599 N S Q1e a bond H a bond NH O a bond Q3b OH
    600 N S Q1e a bond H a bond NH O a bond Q3c OH
    601 N S Q1f a bond Me a bond NH S NH Q3a OH
    602 N S Q1f a bond Me a bond NH S NH Q3b OH
    603 N S Q1f a bond Me a bond NH S NH Q3c OH
    604 N S Q1f a bond Me a bond NH S a bond Q3a OH
    605 N S Q1f a bond Me a bond NH S a bond Q3b OH
    606 N S Q1f a bond Me a bond NH S a bond Q3c OH
    607 N S Q1f a bond Me a bond NH O NH Q3a OH
    608 N S Q1f a bond Me a bond NH O NH Q3b OH
    609 N S Q1f a bond Me a bond NH O NH Q3c OH
    610 N S Q1f a bond Me a bond NH O a bond Q3a OH
    611 N S Q1f a bond Me a bond NH O a bond Q3b OH
    612 N S Q1f a bond Me a bond NH O a bond Q3c OH
    613 N S Q1f a bond H a bond NH S NH Q3a OH
    614 N S Q1f a bond H a bond NH S NH Q3b OH
    615 N S Q1f a bond H a bond NH S NH Q3c OH
    616 N S Q1f a bond H a bond NH S a bond Q3a OH
    617 N S Q1f a bond H a bond NH S a bond Q3b OH
    618 N S Q1f a bond H a bond NH S a bond Q3c OH
    619 N S Q1f a bond H a bond NH O NH Q3a OH
    620 N S Q1f a bond H a bond NH O NH Q3b OH
    621 N S Q1f a bond H a bond NH O NH Q3c OH
    622 N S Q1f a bond H a bond NH O a bond Q3a OH
    623 N S Q1f a bond H a bond NH O a bond Q3b OH
    624 N S Q1f a bond H a bond NH O a bond Q3c OH
    625 N S Q1g a bond Me a bond NH S NH Q3a OH
    626 N S Q1g a bond Me a bond NH S NH Q3b OH
    627 N S Q1g a bond Me a bond NH S NH Q3c OH
    628 N S Q1g a bond Me a bond NH S a bond Q3a OH
    629 N S Q1g a bond Me a bond NH S a bond Q3b OH
    630 N S Q1g a bond Me a bond NH S a bond Q3c OH
    631 N S Q1g a bond Me a bond NH O NH Q3a OH
    632 N S Q1g a bond Me a bond NH O NH Q3b OH
    633 N S Q1g a bond Me a bond NH O NH Q3c OH
    634 N S Q1g a bond Me a bond NH O a bond Q3a OH
    635 N S Q1g a bond Me a bond NH O a bond Q3b OH
    636 N S Q1g a bond Me a bond NH O a bond Q3c OH
    637 N S Q1g a bond H a bond NH S NH Q3a OH
    638 N S Q1g a bond H a bond NH S NH Q3b OH
    639 N S Q1g a bond H a bond NH S NH Q3c OH
    640 N S Q1g a bond H a bond NH S a bond Q3a OH
    641 N S Q1g a bond H a bond NH S a bond Q3b OH
    642 N S Q1g a bond H a bond NH S a bond Q3c OH
    643 N S Q1g a bond H a bond NH O NH Q3a OH
    644 N S Q1g a bond H a bond NH O NH Q3b OH
    645 N S Q1g a bond H a bond NH O NH Q3c OH
    646 N S Q1g a bond H a bond NH O a bond Q3a OH
    647 N S Q1g a bond H a bond NH O a bond Q3b OH
    648 N S Q1g a bond H a bond NH O a bond Q3c OH
    649 N S Q1h a bond Me a bond NH S NH Q3a OH
    650 N S Q1h a bond Me a bond NH S NH Q3b OH
    651 N S Q1h a bond Me a bond NH S NH Q3c OH
    652 N S Q1h a bond Me a bond NH S a bond Q3a OH
    653 N S Q1h a bond Me a bond NH S a bond Q3b OH
    654 N S Q1h a bond Me a bond NH S a bond Q3c OH
    655 N S Q1h a bond Me a bond NH O NH Q3a OH
    656 N S Q1h a bond Me a bond NH O NH Q3b OH
    657 N S Q1h a bond Me a bond NH O NH Q3c OH
    658 N S Q1h a bond Me a bond NH O a bond Q3a OH
    659 N S Q1h a bond Me a bond NH O a bond Q3b OH
    660 N S Q1h a bond Me a bond NH O a bond Q3c OH
    661 N S Q1h a bond H a bond NH S NH Q3a OH
    662 N S Q1h a bond H a bond NH S NH Q3b OH
    663 N S Q1h a bond H a bond NH S NH Q3c OH
    664 N S Q1h a bond H a bond NH S a bond Q3a OH
    665 N S Q1h a bond H a bond NH S a bond Q3b OH
    666 N S Q1h a bond H a bond NH S a bond Q3c OH
    667 N S Q1h a bond H a bond NH O NH Q3a OH
    668 N S Q1h a bond H a bond NH O NH Q3b OH
    669 N S Q1h a bond H a bond NH O NH Q3c OH
    670 N S Q1h a bond H a bond NH O a bond Q3a OH
    671 N S Q1h a bond H a bond NH O a bond Q3b OH
    672 N S Q1h a bond H a bond NH O a bond Q3c OH
    673 N S Q1i a bond Me a bond NH S NH Q3a OH
    674 N S Q1i a bond Me a bond NH S NH Q3b OH
    675 N S Q1i a bond Me a bond NH S NH Q3c OH
    676 N S Q1i a bond Me a bond NH S a bond Q3a OH
    677 N S Q1i a bond Me a bond NH S a bond Q3b OH
    678 N S Q1i a bond Me a bond NH S a bond Q3c OH
    679 N S Q1i a bond Me a bond NH O NH Q3a OH
    680 N S Q1i a bond Me a bond NH O NH Q3b OH
    681 N S Q1i a bond Me a bond NH O NH Q3c OH
    682 N S Q1i a bond Me a bond NH O a bond Q3a OH
    683 N S Q1i a bond Me a bond NH O a bond Q3b OH
    684 N S Q1i a bond Me a bond NH O a bond Q3c OH
    685 N S Q1i a bond H a bond NH S NH Q3a OH
    686 N S Q1i a bond H a bond NH S NH Q3b OH
    687 N S Q1i a bond H a bond NH S NH Q3c OH
    688 N S Q1i a bond H a bond NH S a bond Q3a OH
    689 N S Q1i a bond H a bond NH S a bond Q3b OH
    690 N S Q1i a bond H a bond NH S a bond Q3c OH
    691 N S Q1i a bond H a bond NH O NH Q3a OH
    692 N S Q1i a bond H a bond NH O NH Q3b OH
    693 N S Q1i a bond H a bond NH O NH Q3c OH
    694 N S Q1i a bond H a bond NH O a bond Q3a OH
    695 N S Q1i a bond H a bond NH O a bond Q3b OH
    696 N S Q1i a bond H a bond NH O a bond Q3c OH
    697 N S Q1j a bond Me a bond NH S NH Q3a OH
    698 N S Q1j a bond Me a bond NH S NH Q3b OH
    699 N S Q1j a bond Me a bond NH S NH Q3c OH
    700 N S Q1j a bond Me a bond NH S a bond Q3a OH
    701 N S Q1j a bond Me a bond NH S a bond Q3b OH
    702 N S Q1j a bond Me a bond NH S a bond Q3c OH
    703 N S Q1j a bond Me a bond NH O NH Q3a OH
    704 N S Q1j a bond Me a bond NH O NH Q3b OH
    705 N S Q1j a bond Me a bond NH O NH Q3c OH
    706 N S Q1j a bond Me a bond NH O a bond Q3a OH
    707 N S Q1j a bond Me a bond NH O a bond Q3b OH
    708 N S Q1j a bond Me a bond NH O a bond Q3c OH
    709 N S Q1j a bond H a bond NH S NH Q3a OH
    710 N S Q1j a bond H a bond NH S NH Q3b OH
    711 N S Q1j a bond H a bond NH S NH Q3c OH
    712 N S Q1j a bond H a bond NH S a bond Q3a OH
    713 N S Q1j a bond H a bond NH S a bond Q3b OH
    714 N S Q1j a bond H a bond NH S a bond Q3c OH
    715 N S Q1j a bond H a bond NH O NH Q3a OH
    716 N S Q1j a bond H a bond NH O NH Q3b OH
    717 N S Q1j a bond H a bond NH O NH Q3c OH
    718 N S Q1j a bond H a bond NH O a bond Q3a OH
    719 N S Q1j a bond H a bond NH O a bond Q3b OH
    720 N S Q1j a bond H a bond NH O a bond Q3c OH
    721 N O Q1a a bond Me a bond NH S NH Q3a OH
    722 N O Q1a a bond Me a bond NH S NH Q3b OH
    723 N O Q1a a bond Me a bond NH S NH Q3c OH
    724 N O Q1a a bond Me a bond NH S a bond Q3a OH
    725 N O Q1a a bond Me a bond NH S a bond Q3b OH
    726 N O Q1a a bond Me a bond NH S a bond Q3c OH
    727 N O Q1a a bond Me a bond NH O NH Q3a OH
    728 N O Q1a a bond Me a bond NH O NH Q3b OH
    729 N O Q1a a bond Me a bond NH O NH Q3c OH
    730 N O Q1a a bond Me a bond NH O a bond Q3a OH
    731 N O Q1a a bond Me a bond NH O a bond Q3b OH
    732 N O Q1a a bond Me a bond NH O a bond Q3c OH
    733 N O Q1a a bond H a bond NH S NH Q3a OH
    734 N O Q1a a bond H a bond NH S NH Q3b OH
    735 N O Q1a a bond H a bond NH S NH Q3c OH
    736 N O Q1a a bond H a bond NH S a bond Q3a OH
    737 N O Q1a a bond H a bond NH S a bond Q3b OH
    738 N O Q1a a bond H a bond NH S a bond Q3c OH
    739 N O Q1a a bond H a bond NH O NH Q3a OH
    740 N O Q1a a bond H a bond NH O NH Q3b OH
    741 N O Q1a a bond H a bond NH O NH Q3c OH
    742 N O Q1a a bond H a bond NH O a bond Q3a OH
    743 N O Q1a a bond H a bond NH O a bond Q3b OH
    744 N O Q1a a bond H a bond NH O a bond Q3c OH
    745 N O Q1b a bond Me a bond NH S NH Q3a OH
    746 N O Q1b a bond Me a bond NH S NH Q3b OH
    747 N O Q1b a bond Me a bond NH S NH Q3c OH
    748 N O Q1b a bond Me a bond NH S a bond Q3a OH
    749 N O Q1b a bond Me a bond NH S a bond Q3b OH
    750 N O Q1b a bond Me a bond NH S a bond Q3c OH
    751 N O Q1b a bond Me a bond NH O NH Q3a OH
    752 N O Q1b a bond Me a bond NH O NH Q3b OH
    753 N O Q1b a bond Me a bond NH O NH Q3c OH
    754 N O Q1b a bond Me a bond NH O a bond Q3a OH
    755 N O Q1b a bond Me a bond NH O a bond Q3b OH
    756 N O Q1b a bond Me a bond NH O a bond Q3c OH
    757 N O Q1b a bond H a bond NH S NH Q3a OH
    758 N O Q1b a bond H a bond NH S NH Q3b OH
    759 N O Q1b a bond H a bond NH S NH Q3c OH
    760 N O Q1b a bond H a bond NH S a bond Q3a OH
    761 N O Q1b a bond H a bond NH S a bond Q3b OH
    762 N O Q1b a bond H a bond NH S a bond Q3c OH
    763 N O Q1b a bond H a bond NH O NH Q3a OH
    764 N O Q1b a bond H a bond NH O NH Q3b OH
    765 N O Q1b a bond H a bond NH O NH Q3c OH
    766 N O Q1b a bond H a bond NH O a bond Q3a OH
    767 N O Q1b a bond H a bond NH O a bond Q3b OH
    768 N O Q1b a bond H a bond NH O a bond Q3c OH
    769 N O Q1c a bond Me a bond NH S NH Q3a OH
    770 N O Q1c a bond Me a bond NH S NH Q3b OH
    771 N O Q1c a bond Me a bond NH S NH Q3c OH
    772 N O Q1c a bond Me a bond NH S a bond Q3a OH
    773 N O Q1c a bond Me a bond NH S a bond Q3b OH
    774 N O Q1c a bond Me a bond NH S a bond Q3c OH
    775 N O Q1c a bond Me a bond NH O NH Q3a OH
    776 N O Q1c a bond Me a bond NH O NH Q3b OH
    777 N O Q1c a bond Me a bond NH O NH Q3c OH
    778 N O Q1c a bond Me a bond NH O a bond Q3a OH
    779 N O Q1c a bond Me a bond NH O a bond Q3b OH
    780 N O Q1c a bond Me a bond NH O a bond Q3c OH
    781 N O Q1c a bond H a bond NH S NH Q3a OH
    782 N O Q1c a bond H a bond NH S NH Q3b OH
    783 N O Q1c a bond H a bond NH S NH Q3c OH
    784 N O Q1c a bond H a bond NH S a bond Q3a OH
    785 N O Q1c a bond H a bond NH S a bond Q3b OH
    786 N O Q1c a bond H a bond NH S a bond Q3c OH
    787 N O Q1c a bond H a bond NH O NH Q3a OH
    788 N O Q1c a bond H a bond NH O NH Q3b OH
    789 N O Q1c a bond H a bond NH O NH Q3c OH
    790 N O Q1c a bond H a bond NH O a bond Q3a OH
    791 N O Q1c a bond H a bond NH O a bond Q3b OH
    792 N O Q1c a bond H a bond NH O a bond Q3c OH
    793 N O Q1d a bond Me a bond NH S NH Q3a OH
    794 N O Q1d a bond Me a bond NH S NH Q3b OH
    795 N O Q1d a bond Me a bond NH S NH Q3c OH
    796 N O Q1d a bond Me a bond NH S a bond Q3a OH
    797 N O Q1d a bond Me a bond NH S a bond Q3b OH
    798 N O Q1d a bond Me a bond NH S a bond Q3c OH
    799 N O Q1d a bond Me a bond NH O NH Q3a OH
    800 N O Q1d a bond Me a bond NH O NH Q3b OH
    801 N O Q1d a bond Me a bond NH O NH Q3c OH
    802 N O Q1d a bond Me a bond NH O a bond Q3a OH
    803 N O Q1d a bond Me a bond NH O a bond Q3b OH
    804 N O Q1d a bond Me a bond NH O a bond Q3c OH
    805 N O Q1d a bond H a bond NH S NH Q3a OH
    806 N O Q1d a bond H a bond NH S NH Q3b OH
    807 N O Q1d a bond H a bond NH S NH Q3c OH
    808 N O Q1d a bond H a bond NH S a bond Q3a OH
    809 N O Q1d a bond H a bond NH S a bond Q3b OH
    810 N O Q1d a bond H a bond NH S a bond Q3c OH
    811 N O Q1d a bond H a bond NH O NH Q3a OH
    812 N O Q1d a bond H a bond NH O NH Q3b OH
    813 N O Q1d a bond H a bond NH O NH Q3c OH
    814 N O Q1d a bond H a bond NH O a bond Q3a OH
    815 N O Q1d a bond H a bond NH O a bond Q3b OH
    816 N O Q1d a bond H a bond NH O a bond Q3c OH
    817 N O Q1e a bond Me a bond NH S NH Q3a OH
    818 N O Q1e a bond Me a bond NH S NH Q3b OH
    819 N O Q1e a bond Me a bond NH S NH Q3c OH
    820 N O Q1e a bond Me a bond NH S a bond Q3a OH
    821 N O Q1e a bond Me a bond NH S a bond Q3b OH
    822 N O Q1e a bond Me a bond NH S a bond Q3c OH
    823 N O Q1e a bond Me a bond NH O NH Q3a OH
    824 N O Q1e a bond Me a bond NH O NH Q3b OH
    825 N O Q1e a bond Me a bond NH O NH Q3c OH
    826 N O Q1e a bond Me a bond NH O a bond Q3a OH
    827 N O Q1e a bond Me a bond NH O a bond Q3b OH
    828 N O Q1e a bond Me a bond NH O a bond Q3c OH
    829 N O Q1e a bond H a bond NH S NH Q3a OH
    830 N O Q1e a bond H a bond NH S NH Q3b OH
    831 N O Q1e a bond H a bond NH S NH Q3c OH
    832 N O Q1e a bond H a bond NH S a bond Q3a OH
    833 N O Q1e a bond H a bond NH S a bond Q3b OH
    834 N O Q1e a bond H a bond NH S a bond Q3c OH
    835 N O Q1e a bond H a bond NH O NH Q3a OH
    836 N O Q1e a bond H a bond NH O NH Q3b OH
    837 N O Q1e a bond H a bond NH O NH Q3c OH
    838 N O Q1e a bond H a bond NH O a bond Q3a OH
    839 N O Q1e a bond H a bond NH O a bond Q3b OH
    840 N O Q1e a bond H a bond NH O a bond Q3c OH
    841 N O Q1f a bond Me a bond NH S NH Q3a OH
    842 N O Q1f a bond Me a bond NH S NH Q3b OH
    843 N O Q1f a bond Me a bond NH S NH Q3c OH
    844 N O Q1f a bond Me a bond NH S a bond Q3a OH
    845 N O Q1f a bond Me a bond NH S a bond Q3b OH
    846 N O Q1f a bond Me a bond NH S a bond Q3c OH
    847 N O Q1f a bond Me a bond NH O NH Q3a OH
    848 N O Q1f a bond Me a bond NH O NH Q3b OH
    849 N O Q1f a bond Me a bond NH O NH Q3c OH
    850 N O Q1f a bond Me a bond NH O a bond Q3a OH
    851 N O Q1f a bond Me a bond NH O a bond Q3b OH
    852 N O Q1f a bond Me a bond NH O a bond Q3c OH
    853 N O Q1f a bond H a bond NH S NH Q3a OH
    854 N O Q1f a bond H a bond NH S NH Q3b OH
    855 N O Q1f a bond H a bond NH S NH Q3c OH
    856 N O Q1f a bond H a bond NH S a bond Q3a OH
    857 N O Q1f a bond H a bond NH S a bond Q3b OH
    858 N O Q1f a bond H a bond NH S a bond Q3c OH
    859 N O Q1f a bond H a bond NH O NH Q3a OH
    860 N O Q1f a bond H a bond NH O NH Q3b OH
    861 N O Q1f a bond H a bond NH O NH Q3c OH
    862 N O Q1f a bond H a bond NH O a bond Q3a OH
    863 N O Q1f a bond H a bond NH O a bond Q3b OH
    864 N O Q1f a bond H a bond NH O a bond Q3c OH
    865 N O Q1g a bond Me a bond NH S NH Q3a OH
    866 N O Q1g a bond Me a bond NH S NH Q3b OH
    867 N O Q1g a bond Me a bond NH S NH Q3c OH
    868 N O Q1g a bond Me a bond NH S a bond Q3a OH
    869 N O Q1g a bond Me a bond NH S a bond Q3b OH
    870 N O Q1g a bond Me a bond NH S a bond Q3c OH
    871 N O Q1g a bond Me a bond NH O NH Q3a OH
    872 N O Q1g a bond Me a bond NH O NH Q3b OH
    873 N O Q1g a bond Me a bond NH O NH Q3c OH
    874 N O Q1g a bond Me a bond NH O a bond Q3a OH
    875 N O Q1g a bond Me a bond NH O a bond Q3b OH
    876 N O Q1g a bond Me a bond NH O a bond Q3c OH
    877 N O Q1g a bond H a bond NH S NH Q3a OH
    878 N O Q1g a bond H a bond NH S NH Q3b OH
    879 N O Q1g a bond H a bond NH S NH Q3c OH
    880 N O Q1g a bond H a bond NH S a bond Q3a OH
    881 N O Q1g a bond H a bond NH S a bond Q3b OH
    882 N O Q1g a bond H a bond NH S a bond Q3c OH
    883 N O Q1g a bond H a bond NH O NH Q3a OH
    884 N O Q1g a bond H a bond NH O NH Q3b OH
    885 N O Q1g a bond H a bond NH O NH Q3c OH
    886 N O Q1g a bond H a bond NH O a bond Q3a OH
    887 N O Q1g a bond H a bond NH O a bond Q3b OH
    888 N O Q1g a bond H a bond NH O a bond Q3c OH
    889 N O Q1h a bond Me a bond NH S NH Q3a OH
    890 N O Q1h a bond Me a bond NH S NH Q3b OH
    891 N O Q1h a bond Me a bond NH S NH Q3c OH
    892 N O Q1h a bond Me a bond NH S a bond Q3a OH
    893 N O Q1h a bond Me a bond NH S a bond Q3b OH
    894 N O Q1h a bond Me a bond NH S a bond Q3c OH
    895 N O Q1h a bond Me a bond NH O NH Q3a OH
    896 N O Q1h a bond Me a bond NH O NH Q3b OH
    897 N O Q1h a bond Me a bond NH O NH Q3c OH
    898 N O Q1h a bond Me a bond NH O a bond Q3a OH
    899 N O Q1h a bond Me a bond NH O a bond Q3b OH
    900 N O Q1h a bond Me a bond NH O a bond Q3c OH
    901 N O Q1h a bond H a bond NH S NH Q3a OH
    902 N O Q1h a bond H a bond NH S NH Q3b OH
    903 N O Q1h a bond H a bond NH S NH Q3c OH
    904 N O Q1h a bond H a bond NH S a bond Q3a OH
    905 N O Q1h a bond H a bond NH S a bond Q3b OH
    906 N O Q1h a bond H a bond NH S a bond Q3c OH
    907 N O Q1h a bond H a bond NH O NH Q3a OH
    908 N O Q1h a bond H a bond NH O NH Q3b OH
    909 N O Q1h a bond H a bond NH O NH Q3c OH
    910 N O Q1h a bond H a bond NH O a bond Q3a OH
    911 N O Q1h a bond H a bond NH O a bond Q3b OH
    912 N O Q1h a bond H a bond NH O a bond Q3c OH
    913 N O Q1i a bond Me a bond NH S NH Q3a OH
    914 N O Q1i a bond Me a bond NH S NH Q3b OH
    915 N O Q1i a bond Me a bond NH S NH Q3c OH
    916 N O Q1i a bond Me a bond NH S a bond Q3a OH
    917 N O Q1i a bond Me a bond NH S a bond Q3b OH
    918 N O Q1i a bond Me a bond NH S a bond Q3c OH
    919 N O Q1i a bond Me a bond NH O NH Q3a OH
    920 N O Q1i a bond Me a bond NH O NH Q3b OH
    921 N O Q1i a bond Me a bond NH O NH Q3c OH
    922 N O Q1i a bond Me a bond NH O a bond Q3a OH
    923 N O Q1i a bond Me a bond NH O a bond Q3b OH
    924 N O Q1i a bond Me a bond NH O a bond Q3c OH
    925 N O Q1i a bond H a bond NH S NH Q3a OH
    926 N O Q1i a bond H a bond NH S NH Q3b OH
    927 N O Q1i a bond H a bond NH S NH Q3c OH
    928 N O Q1i a bond H a bond NH S a bond Q3a OH
    929 N O Q1i a bond H a bond NH S a bond Q3b OH
    930 N O Q1i a bond H a bond NH S a bond Q3c OH
    931 N O Q1i a bond H a bond NH O NH Q3a OH
    932 N O Q1i a bond H a bond NH O NH Q3b OH
    933 N O Q1i a bond H a bond NH O NH Q3c OH
    934 N O Q1i a bond H a bond NH O a bond Q3a OH
    935 N O Q1i a bond H a bond NH O a bond Q3b OH
    936 N O Q1i a bond H a bond NH O a bond Q3c OH
    937 N O Q1j a bond Me a bond NH S NH Q3a OH
    938 N O Q1j a bond Me a bond NH S NH Q3b OH
    939 N O Q1j a bond Me a bond NH S NH Q3c OH
    940 N O Q1j a bond Me a bond NH S a bond Q3a OH
    941 N O Q1j a bond Me a bond NH S a bond Q3b OH
    942 N O Q1j a bond Me a bond NH S a bond Q3c OH
    943 N O Q1j a bond Me a bond NH O NH Q3a OH
    944 N O Q1j a bond Me a bond NH O NH Q3b OH
    945 N O Q1j a bond Me a bond NH O NH Q3c OH
    946 N O Q1j a bond Me a bond NH O a bond Q3a OH
    947 N O Q1j a bond Me a bond NH O a bond Q3b OH
    948 N O Q1j a bond Me a bond NH O a bond Q3c OH
    949 N O Q1j a bond H a bond NH S NH Q3a OH
    950 N O Q1j a bond H a bond NH S NH Q3b OH
    951 N O Q1j a bond H a bond NH S NH Q3c OH
    952 N O Q1j a bond H a bond NH S a bond Q3a OH
    953 N O Q1j a bond H a bond NH S a bond Q3b OH
    954 N O Q1j a bond H a bond NH S a bond Q3c OH
    955 N O Q1j a bond H a bond NH O NH Q3a OH
    956 N O Q1j a bond H a bond NH O NH Q3b OH
    957 N O Q1j a bond H a bond NH O NH Q3c OH
    958 N O Q1j a bond H a bond NH O a bond Q3a OH
    959 N O Q1j a bond H a bond NH O a bond Q3b OH
    960 N O Q1j a bond H a bond NH O a bond Q3c OH
    961 CH NMe Q1a a bond Me a bond NH S NH Q3a OH
    962 CH NMe Q1a a bond Me a bond NH S NH Q3b OH
    963 CH NMe Q1a a bond Me a bond NH S NH Q3c OH
    964 CH NMe Q1a a bond Me a bond NH S a bond Q3a OH
    965 CH NMe Q1a a bond Me a bond NH S a bond Q3b OH
    966 CH NMe Q1a a bond Me a bond NH S a bond Q3c OH
    967 CH NMe Q1a a bond Me a bond NH O NH Q3a OH
    968 CH NMe Q1a a bond Me a bond NH O NH Q3b OH
    969 CH NMe Q1a a bond Me a bond NH O NH Q3c OH
    970 CH NMe Q1a a bond Me a bond NH O a bond Q3a OH
    971 CH NMe Q1a a bond Me a bond NH O a bond Q3b OH
    972 CH NMe Q1a a bond Me a bond NH O a bond Q3c OH
    973 CH NMe Q1a a bond H a bond NH S NH Q3a OH
    974 CH NMe Q1a a bond H a bond NH S NH Q3b OH
    975 CH NMe Q1a a bond H a bond NH S NH Q3c OH
    976 CH NMe Q1a a bond H a bond NH S a bond Q3a OH
    977 CH NMe Q1a a bond H a bond NH S a bond Q3b OH
    978 CH NMe Q1a a bond H a bond NH S a bond Q3c OH
    979 CH NMe Q1a a bond H a bond NH O NH Q3a OH
    980 CH NMe Q1a a bond H a bond NH O NH Q3b OH
    981 CH NMe Q1a a bond H a bond NH O NH Q3c OH
    982 CH NMe Q1a a bond H a bond NH O a bond Q3a OH
    983 CH NMe Q1a a bond H a bond NH O a bond Q3b OH
    984 CH NMe Q1a a bond H a bond NH O a bond Q3c OH
    985 CH NMe Q1b a bond Me a bond NH S NH Q3a OH
    986 CH NMe Q1b a bond Me a bond NH S NH Q3b OH
    987 CH NMe Q1b a bond Me a bond NH S NH Q3c OH
    988 CH NMe Q1b a bond Me a bond NH S a bond Q3a OH
    989 CH NMe Q1b a bond Me a bond NH S a bond Q3b OH
    990 CH NMe Q1b a bond Me a bond NH S a bond Q3c OH
    991 CH NMe Q1b a bond Me a bond NH O NH Q3a OH
    992 CH NMe Q1b a bond Me a bond NH O NH Q3b OH
    993 CH NMe Q1b a bond Me a bond NH O NH Q3c OH
    994 CH NMe Q1b a bond Me a bond NH O a bond Q3a OH
    995 CH NMe Q1b a bond Me a bond NH O a bond Q3b OH
    996 CH NMe Q1b a bond Me a bond NH O a bond Q3c OH
    997 CH NMe Q1b a bond H a bond NH S NH Q3a OH
    998 CH NMe Q1b a bond H a bond NH S NH Q3b OH
    999 CH NMe Q1b a bond H a bond NH S NH Q3c OH
    1000 CH NMe Q1b a bond H a bond NH S a bond Q3a OH
    1001 CH NMe Q1b a bond H a bond NH S a bond Q3b OH
    1002 CH NMe Q1b a bond H a bond NH S a bond Q3c OH
    1003 CH NMe Q1b a bond H a bond NH O NH Q3a OH
    1004 CH NMe Q1b a bond H a bond NH O NH Q3b OH
    1005 CH NMe Q1b a bond H a bond NH O NH Q3c OH
    1006 CH NMe Q1b a bond H a bond NH O a bond Q3a OH
    1007 CH NMe Q1b a bond H a bond NH O a bond Q3b OH
    1008 CH NMe Q1b a bond H a bond NH O a bond Q3c OH
    1009 CH NMe Q1c a bond Me a bond NH S NH Q3a OH
    1010 CH NMe Q1c a bond Me a bond NH S NH Q3b OH
    1011 CH NMe Q1c a bond Me a bond NH S NH Q3c OH
    1012 CH NMe Q1c a bond Me a bond NH S a bond Q3a OH
    1013 CH NMe Q1c a bond Me a bond NH S a bond Q3b OH
    1014 CH NMe Q1c a bond Me a bond NH S a bond Q3c OH
    1015 CH NMe Q1c a bond Me a bond NH O NH Q3a OH
    1016 CH NMe Q1c a bond Me a bond NH O NH Q3b OH
    1017 CH NMe Q1c a bond Me a bond NH O NH Q3c OH
    1018 CH NMe Q1c a bond Me a bond NH O a bond Q3a OH
    1019 CH NMe Q1c a bond Me a bond NH O a bond Q3b OH
    1020 CH NMe Q1c a bond Me a bond NH O a bond Q3c OH
    1021 CH NMe Q1c a bond H a bond NH S NH Q3a OH
    1022 CH NMe Q1c a bond H a bond NH S NH Q3b OH
    1023 CH NMe Q1c a bond H a bond NH S NH Q3c OH
    1024 CH NMe Q1c a bond H a bond NH S a bond Q3a OH
    1025 CH NMe Q1c a bond H a bond NH S a bond Q3b OH
    1026 CH NMe Q1c a bond H a bond NH S a bond Q3c OH
    1027 CH NMe Q1c a bond H a bond NH O NH Q3a OH
    1028 CH NMe Q1c a bond H a bond NH O NH Q3b OH
    1029 CH NMe Q1c a bond H a bond NH O NH Q3c OH
    1030 CH NMe Q1c a bond H a bond NH O a bond Q3a OH
    1031 CH NMe Q1c a bond H a bond NH O a bond Q3b OH
    1032 CH NMe Q1c a bond H a bond NH O a bond Q3c OH
    1033 CH NMe Q1d a bond Me a bond NH S NH Q3a OH
    1034 CH NMe Q1d a bond Me a bond NH S NH Q3b OH
    1035 CH NMe Q1d a bond Me a bond NH S NH Q3c OH
    1036 CH NMe Q1d a bond Me a bond NH S a bond Q3a OH
    1037 CH NMe Q1d a bond Me a bond NH S a bond Q3b OH
    1038 CH NMe Q1d a bond Me a bond NH S a bond Q3c OH
    1039 CH NMe Q1d a bond Me a bond NH O NH Q3a OH
    1040 CH NMe Q1d a bond Me a bond NH O NH Q3b OH
    1041 CH NMe Q1d a bond Me a bond NH O NH Q3c OH
    1042 CH NMe Q1d a bond Me a bond NH O a bond Q3a OH
    1043 CH NMe Q1d a bond Me a bond NH O a bond Q3b OH
    1044 CH NMe Q1d a bond Me a bond NH O a bond Q3c OH
    1045 CH NMe Q1d a bond H a bond NH S NH Q3a OH
    1046 CH NMe Q1d a bond H a bond NH S NH Q3b OH
    1047 CH NMe Q1d a bond H a bond NH S NH Q3c OH
    1048 CH NMe Q1d a bond H a bond NH S a bond Q3a OH
    1049 CH NMe Q1d a bond H a bond NH S a bond Q3b OH
    1050 CH NMe Q1d a bond H a bond NH S a bond Q3c OH
    1051 CH NMe Q1d a bond H a bond NH O NH Q3a OH
    1052 CH NMe Q1d a bond H a bond NH O NH Q3b OH
    1053 CH NMe Q1d a bond H a bond NH O NH Q3c OH
    1054 CH NMe Q1d a bond H a bond NH O a bond Q3a OH
    1055 CH NMe Q1d a bond H a bond NH O a bond Q3b OH
    1056 CH NMe Q1d a bond H a bond NH O a bond Q3c OH
    1057 CH NMe Q1e a bond Me a bond NH S NH Q3a OH
    1058 CH NMe Q1e a bond Me a bond NH S NH Q3b OH
    1059 CH NMe Q1e a bond Me a bond NH S NH Q3c OH
    1060 CH NMe Q1e a bond Me a bond NH S a bond Q3a OH
    1061 CH NMe Q1e a bond Me a bond NH S a bond Q3b OH
    1062 CH NMe Q1e a bond Me a bond NH S a bond Q3c OH
    1063 CH NMe Q1e a bond Me a bond NH O NH Q3a OH
    1064 CH NMe Q1e a bond Me a bond NH O NH Q3b OH
    1065 CH NMe Q1e a bond Me a bond NH O NH Q3c OH
    1066 CH NMe Q1e a bond Me a bond NH O a bond Q3a OH
    1067 CH NMe Q1e a bond Me a bond NH O a bond Q3b OH
    1068 CH NMe Q1e a bond Me a bond NH O a bond Q3c OH
    1069 CH NMe Q1e a bond H a bond NH S NH Q3a OH
    1070 CH NMe Q1e a bond H a bond NH S NH Q3b OH
    1071 CH NMe Q1e a bond H a bond NH S NH Q3c OH
    1072 CH NMe Q1e a bond H a bond NH S a bond Q3a OH
    1073 CH NMe Q1e a bond H a bond NH S a bond Q3b OH
    1074 CH NMe Q1e a bond H a bond NH S a bond Q3c OH
    1075 CH NMe Q1e a bond H a bond NH O NH Q3a OH
    1076 CH NMe Q1e a bond H a bond NH O NH Q3b OH
    1077 CH NMe Q1e a bond H a bond NH O NH Q3c OH
    1078 CH NMe Q1e a bond H a bond NH O a bond Q3a OH
    1079 CH NMe Q1e a bond H a bond NH O a bond Q3b OH
    1080 CH NMe Q1e a bond H a bond NH O a bond Q3c OH
    1081 CH NMe Q1f a bond Me a bond NH S NH Q3a OH
    1082 CH NMe Q1f a bond Me a bond NH S NH Q3b OH
    1083 CH NMe Q1f a bond Me a bond NH S NH Q3c OH
    1084 CH NMe Q1f a bond Me a bond NH S a bond Q3a OH
    1085 CH NMe Q1f a bond Me a bond NH S a bond Q3b OH
    1086 CH NMe Q1f a bond Me a bond NH S a bond Q3c OH
    1087 CH NMe Q1f a bond Me a bond NH O NH Q3a OH
    1088 CH NMe Q1f a bond Me a bond NH O NH Q3b OH
    1089 CH NMe Q1f a bond Me a bond NH O NH Q3c OH
    1090 CH NMe Q1f a bond Me a bond NH O a bond Q3a OH
    1091 CH NMe Q1f a bond Me a bond NH O a bond Q3b OH
    1092 CH NMe Q1f a bond Me a bond NH O a bond Q3c OH
    1093 CH NMe Q1f a bond H a bond NH S NH Q3a OH
    1094 CH NMe Q1f a bond H a bond NH S NH Q3b OH
    1095 CH NMe Q1f a bond H a bond NH S NH Q3c OH
    1096 CH NMe Q1f a bond H a bond NH S a bond Q3a OH
    1097 CH NMe Q1f a bond H a bond NH S a bond Q3b OH
    1098 CH NMe Q1f a bond H a bond NH S a bond Q3c OH
    1099 CH NMe Q1f a bond H a bond NH O NH Q3a OH
    1100 CH NMe Q1f a bond H a bond NH O NH Q3b OH
    1101 CH NMe Q1f a bond H a bond NH O NH Q3c OH
    1102 CH NMe Q1f a bond H a bond NH O a bond Q3a OH
    1103 CH NMe Q1f a bond H a bond NH O a bond Q3b OH
    1104 CH NMe Q1f a bond H a bond NH O a bond Q3c OH
    1105 CH NMe Q1g a bond Me a bond NH S NH Q3a OH
    1106 CH NMe Q1g a bond Me a bond NH S NH Q3b OH
    1107 CH NMe Q1g a bond Me a bond NH S NH Q3c OH
    1108 CH NMe Q1g a bond Me a bond NH S a bond Q3a OH
    1109 CH NMe Q1g a bond Me a bond NH S a bond Q3b OH
    1110 CH NMe Q1g a bond Me a bond NH S a bond Q3c OH
    1111 CH NMe Q1g a bond Me a bond NH O NH Q3a OH
    1112 CH NMe Q1g a bond Me a bond NH O NH Q3b OH
    1113 CH NMe Q1g a bond Me a bond NH O NH Q3c OH
    1114 CH NMe Q1g a bond Me a bond NH O a bond Q3a OH
    1115 CH NMe Q1g a bond Me a bond NH O a bond Q3b OH
    1116 CH NMe Q1g a bond Me a bond NH O a bond Q3c OH
    1117 CH NMe Q1g a bond H a bond NH S NH Q3a OH
    1118 CH NMe Q1g a bond H a bond NH S NH Q3b OH
    1119 CH NMe Q1g a bond H a bond NH S NH Q3c OH
    1120 CH NMe Q1g a bond H a bond NH S a bond Q3a OH
    1121 CH NMe Q1g a bond H a bond NH S a bond Q3b OH
    1122 CH NMe Q1g a bond H a bond NH S a bond Q3c OH
    1123 CH NMe Q1g a bond H a bond NH O NH Q3a OH
    1124 CH NMe Q1g a bond H a bond NH O NH Q3b OH
    1125 CH NMe Q1g a bond H a bond NH O NH Q3c OH
    1126 CH NMe Q1g a bond H a bond NH O a bond Q3a OH
    1127 CH NMe Q1g a bond H a bond NH O a bond Q3b OH
    1128 CH NMe Q1g a bond H a bond NH O a bond Q3c OH
    1129 CH NMe Q1h a bond Me a bond NH S NH Q3a OH
    1130 CH NMe Q1h a bond Me a bond NH S NH Q3b OH
    1131 CH NMe Q1h a bond Me a bond NH S NH Q3c OH
    1132 CH NMe Q1h a bond Me a bond NH S a bond Q3a OH
    1133 CH NMe Q1h a bond Me a bond NH S a bond Q3b OH
    1134 CH NMe Q1h a bond Me a bond NH S a bond Q3c OH
    1135 CH NMe Q1h a bond Me a bond NH O NH Q3a OH
    1136 CH NMe Q1h a bond Me a bond NH O NH Q3b OH
    1137 CH NMe Q1h a bond Me a bond NH O NH Q3c OH
    1138 CH NMe Q1h a bond Me a bond NH O a bond Q3a OH
    1139 CH NMe Q1h a bond Me a bond NH O a bond Q3b OH
    1140 CH NMe Q1h a bond Me a bond NH O a bond Q3c OH
    1141 CH NMe Q1h a bond H a bond NH S NH Q3a OH
    1142 CH NMe Q1h a bond H a bond NH S NH Q3b OH
    1143 CH NMe Q1h a bond H a bond NH S NH Q3c OH
    1144 CH NMe Q1h a bond H a bond NH S a bond Q3a OH
    1145 CH NMe Q1h a bond H a bond NH S a bond Q3b OH
    1146 CH NMe Q1h a bond H a bond NH S a bond Q3c OH
    1147 CH NMe Q1h a bond H a bond NH O NH Q3a OH
    1148 CH NMe Q1h a bond H a bond NH O NH Q3b OH
    1149 CH NMe Q1h a bond H a bond NH O NH Q3c OH
    1150 CH NMe Q1h a bond H a bond NH O a bond Q3a OH
    1151 CH NMe Q1h a bond H a bond NH O a bond Q3b OH
    1152 CH NMe Q1h a bond H a bond NH O a bond Q3c OH
    1153 CH NMe Q1i a bond Me a bond NH S NH Q3a OH
    1154 CH NMe Q1i a bond Me a bond NH S NH Q3b OH
    1155 CH NMe Q1i a bond Me a bond NH S NH Q3c OH
    1156 CH NMe Q1i a bond Me a bond NH S a bond Q3a OH
    1157 CH NMe Q1i a bond Me a bond NH S a bond Q3b OH
    1158 CH NMe Q1i a bond Me a bond NH S a bond Q3c OH
    1159 CH NMe Q1i a bond Me a bond NH O NH Q3a OH
    1160 CH NMe Q1i a bond Me a bond NH O NH Q3b OH
    1161 CH NMe Q1i a bond Me a bond NH O NH Q3c OH
    1162 CH NMe Q1i a bond Me a bond NH O a bond Q3a OH
    1163 CH NMe Q1i a bond Me a bond NH O a bond Q3b OH
    1164 CH NMe Q1i a bond Me a bond NH O a bond Q3c OH
    1165 CH NMe Q1i a bond H a bond NH S NH Q3a OH
    1166 CH NMe Q1i a bond H a bond NH S NH Q3b OH
    1167 CH NMe Q1i a bond H a bond NH S NH Q3c OH
    1168 CH NMe Q1i a bond H a bond NH S a bond Q3a OH
    1169 CH NMe Q1i a bond H a bond NH S a bond Q3b OH
    1170 CH NMe Q1i a bond H a bond NH S a bond Q3c OH
    1171 CH NMe Q1i a bond H a bond NH O NH Q3a OH
    1172 CH NMe Q1i a bond H a bond NH O NH Q3b OH
    1173 CH NMe Q1i a bond H a bond NH O NH Q3c OH
    1174 CH NMe Q1i a bond H a bond NH O a bond Q3a OH
    1175 CH NMe Q1i a bond H a bond NH O a bond Q3b OH
    1176 CH NMe Q1i a bond H a bond NH O a bond Q3c OH
    1177 CH NMe Q1j a bond Me a bond NH S NH Q3a OH
    1178 CH NMe Q1j a bond Me a bond NH S NH Q3b OH
    1179 CH NMe Q1j a bond Me a bond NH S NH Q3c OH
    1180 CH NMe Q1j a bond Me a bond NH S a bond Q3a OH
    1181 CH NMe Q1j a bond Me a bond NH S a bond Q3b OH
    1182 CH NMe Q1j a bond Me a bond NH S a bond Q3c OH
    1183 CH NMe Q1j a bond Me a bond NH O NH Q3a OH
    1184 CH NMe Q1j a bond Me a bond NH O NH Q3b OH
    1185 CH NMe Q1j a bond Me a bond NH O NH Q3c OH
    1186 CH NMe Q1j a bond Me a bond NH O a bond Q3a OH
    1187 CH NMe Q1j a bond Me a bond NH O a bond Q3b OH
    1188 CH NMe Q1j a bond Me a bond NH O a bond Q3c OH
    1189 CH NMe Q1j a bond H a bond NH S NH Q3a OH
    1190 CH NMe Q1j a bond H a bond NH S NH Q3b OH
    1191 CH NMe Q1j a bond H a bond NH S NH Q3c OH
    1192 CH NMe Q1j a bond H a bond NH S a bond Q3a OH
    1193 CH NMe Q1j a bond H a bond NH S a bond Q3b OH
    1194 CH NMe Q1j a bond H a bond NH S a bond Q3c OH
    1195 CH NMe Q1j a bond H a bond NH O NH Q3a OH
    1196 CH NMe Q1j a bond H a bond NH O NH Q3b OH
    1197 CH NMe Q1j a bond H a bond NH O NH Q3c OH
    1198 CH NMe Q1j a bond H a bond NH O a bond Q3a OH
    1199 CH NMe Q1j a bond H a bond NH O a bond Q3b OH
    1200 CH NMe Q1j a bond H a bond NH O a bond Q3c OH
    1201 CH NEt Q1a a bond Me a bond NH S NH Q3a OH
    1202 CH NEt Q1a a bond Me a bond NH S NH Q3b OH
    1203 CH NEt Q1a a bond Me a bond NH S NH Q3c OH
    1204 CH NEt Q1a a bond Me a bond NH S a bond Q3a OH
    1205 CH NEt Q1a a bond Me a bond NH S a bond Q3b OH
    1206 CH NEt Q1a a bond Me a bond NH S a bond Q3c OH
    1207 CH NEt Q1a a bond Me a bond NH O NH Q3a OH
    1208 CH NEt Q1a a bond Me a bond NH O NH Q3b OH
    1209 CH NEt Q1a a bond Me a bond NH O NH Q3c OH
    1210 CH NEt Q1a a bond Me a bond NH O a bond Q3a OH
    1211 CH NEt Q1a a bond Me a bond NH O a bond Q3b OH
    1212 CH NEt Q1a a bond Me a bond NH O a bond Q3c OH
    1213 CH NEt Q1a a bond H a bond NH S NH Q3a OH
    1214 CH NEt Q1a a bond H a bond NH S NH Q3b OH
    1215 CH NEt Q1a a bond H a bond NH S NH Q3c OH
    1216 CH NEt Q1a a bond H a bond NH S a bond Q3a OH
    1217 CH NEt Q1a a bond H a bond NH S a bond Q3b OH
    1218 CH NEt Q1a a bond H a bond NH S a bond Q3c OH
    1219 CH NEt Q1a a bond H a bond NH O NH Q3a OH
    1220 CH NEt Q1a a bond H a bond NH O NH Q3b OH
    1221 CH NEt Q1a a bond H a bond NH O NH Q3c OH
    1222 CH NEt Q1a a bond H a bond NH O a bond Q3a OH
    1223 CH NEt Q1a a bond H a bond NH O a bond Q3b OH
    1224 CH NEt Q1a a bond H a bond NH O a bond Q3c OH
    1225 CH NEt Q1b a bond Me a bond NH S NH Q3a OH
    1226 CH NEt Q1b a bond Me a bond NH S NH Q3b OH
    1227 CH NEt Q1b a bond Me a bond NH S NH Q3c OH
    1228 CH NEt Q1b a bond Me a bond NH S a bond Q3a OH
    1229 CH NEt Q1b a bond Me a bond NH S a bond Q3b OH
    1230 CH NEt Q1b a bond Me a bond NH S a bond Q3c OH
    1231 CH NEt Q1b a bond Me a bond NH O NH Q3a OH
    1232 CH NEt Q1b a bond Me a bond NH O NH Q3b OH
    1233 CH NEt Q1b a bond Me a bond NH O NH Q3c OH
    1234 CH NEt Q1b a bond Me a bond NH O a bond Q3a OH
    1235 CH NEt Q1b a bond Me a bond NH O a bond Q3b OH
    1236 CH NEt Q1b a bond Me a bond NH O a bond Q3c OH
    1237 CH NEt Q1b a bond H a bond NH S NH Q3a OH
    1238 CH NEt Q1b a bond H a bond NH S NH Q3b OH
    1239 CH NEt Q1b a bond H a bond NH S NH Q3c OH
    1240 CH NEt Q1b a bond H a bond NH S a bond Q3a OH
    1241 CH NEt Q1b a bond H a bond NH S a bond Q3b OH
    1242 CH NEt Q1b a bond H a bond NH S a bond Q3c OH
    1243 CH NEt Q1b a bond H a bond NH O NH Q3a OH
    1244 CH NEt Q1b a bond H a bond NH O NH Q3b OH
    1245 CH NEt Q1b a bond H a bond NH O NH Q3c OH
    1246 CH NEt Q1b a bond H a bond NH O a bond Q3a OH
    1247 CH NEt Q1b a bond H a bond NH O a bond Q3b OH
    1248 CH NEt Q1b a bond H a bond NH O a bond Q3c OH
    1249 CH NEt Q1c a bond Me a bond NH S NH Q3a OH
    1250 CH NEt Q1c a bond Me a bond NH S NH Q3b OH
    1251 CH NEt Q1c a bond Me a bond NH S NH Q3c OH
    1252 CH NEt Q1c a bond Me a bond NH S a bond Q3a OH
    1253 CH NEt Q1c a bond Me a bond NH S a bond Q3b OH
    1254 CH NEt Q1c a bond Me a bond NH S a bond Q3c OH
    1255 CH NEt Q1c a bond Me a bond NH O NH Q3a OH
    1256 CH NEt Q1c a bond Me a bond NH O NH Q3b OH
    1257 CH NEt Q1c a bond Me a bond NH O NH Q3c OH
    1258 CH NEt Q1c a bond Me a bond NH O a bond Q3a OH
    1259 CH NEt Q1c a bond Me a bond NH O a bond Q3b OH
    1260 CH NEt Q1c a bond Me a bond NH O a bond Q3c OH
    1261 CH NEt Q1c a bond H a bond NH S NH Q3a OH
    1262 CH NEt Q1c a bond H a bond NH S NH Q3b OH
    1263 CH NEt Q1c a bond H a bond NH S NH Q3c OH
    1264 CH NEt Q1c a bond H a bond NH S a bond Q3a OH
    1265 CH NEt Q1c a bond H a bond NH S a bond Q3b OH
    1266 CH NEt Q1c a bond H a bond NH S a bond Q3c OH
    1267 CH NEt Q1c a bond H a bond NH O NH Q3a OH
    1268 CH NEt Q1c a bond H a bond NH O NH Q3b OH
    1269 CH NEt Q1c a bond H a bond NH O NH Q3c OH
    1270 CH NEt Q1c a bond H a bond NH O a bond Q3a OH
    1271 CH NEt Q1c a bond H a bond NH O a bond Q3b OH
    1272 CH NEt Q1c a bond H a bond NH O a bond Q3c OH
    1273 CH NEt Q1d a bond Me a bond NH S NH Q3a OH
    1274 CH NEt Q1d a bond Me a bond NH S NH Q3b OH
    1275 CH NEt Q1d a bond Me a bond NH S NH Q3c OH
    1276 CH NEt Q1d a bond Me a bond NH S a bond Q3a OH
    1277 CH NEt Q1d a bond Me a bond NH S a bond Q3b OH
    1278 CH NEt Q1d a bond Me a bond NH S a bond Q3c OH
    1279 CH NEt Q1d a bond Me a bond NH O NH Q3a OH
    1280 CH NEt Q1d a bond Me a bond NH O NH Q3b OH
    1281 CH NEt Q1d a bond Me a bond NH O NH Q3c OH
    1282 CH NEt Q1d a bond Me a bond NH O a bond Q3a OH
    1283 CH NEt Q1d a bond Me a bond NH O a bond Q3b OH
    1284 CH NEt Q1d a bond Me a bond NH O a bond Q3c OH
    1285 CH NEt Q1d a bond H a bond NH S NH Q3a OH
    1286 CH NEt Q1d a bond H a bond NH S NH Q3b OH
    1287 CH NEt Q1d a bond H a bond NH S NH Q3c OH
    1288 CH NEt Q1d a bond H a bond NH S a bond Q3a OH
    1289 CH NEt Q1d a bond H a bond NH S a bond Q3b OH
    1290 CH NEt Q1d a bond H a bond NH S a bond Q3c OH
    1291 CH NEt Q1d a bond H a bond NH O NH Q3a OH
    1292 CH NEt Q1d a bond H a bond NH O NH Q3b OH
    1293 CH NEt Q1d a bond H a bond NH O NH Q3c OH
    1294 CH NEt Q1d a bond H a bond NH O a bond Q3a OH
    1295 CH NEt Q1d a bond H a bond NH O a bond Q3b OH
    1296 CH NEt Q1d a bond H a bond NH O a bond Q3c OH
    1297 CH NEt Q1e a bond Me a bond NH S NH Q3a OH
    1298 CH NEt Q1e a bond Me a bond NH S NH Q3b OH
    1299 CH NEt Q1e a bond Me a bond NH S NH Q3c OH
    1300 CH NEt Q1e a bond Me a bond NH S a bond Q3a OH
    1301 CH NEt Q1e a bond Me a bond NH S a bond Q3b OH
    1302 CH NEt Q1e a bond Me a bond NH S a bond Q3c OH
    1303 CH NEt Q1e a bond Me a bond NH O NH Q3a OH
    1304 CH NEt Q1e a bond Me a bond NH O NH Q3b OH
    1305 CH NEt Q1e a bond Me a bond NH O NH Q3c OH
    1306 CH NEt Q1e a bond Me a bond NH O a bond Q3a OH
    1307 CH NEt Q1e a bond Me a bond NH O a bond Q3b OH
    1308 CH NEt Q1e a bond Me a bond NH O a bond Q3c OH
    1309 CH NEt Q1e a bond H a bond NH S NH Q3a OH
    1310 CH NEt Q1e a bond H a bond NH S NH Q3b OH
    1311 CH NEt Q1e a bond H a bond NH S NH Q3c OH
    1312 CH NEt Q1e a bond H a bond NH S a bond Q3a OH
    1313 CH NEt Q1e a bond H a bond NH S a bond Q3b OH
    1314 CH NEt Q1e a bond H a bond NH S a bond Q3c OH
    1315 CH NEt Q1e a bond H a bond NH O NH Q3a OH
    1316 CH NEt Q1e a bond H a bond NH O NH Q3b OH
    1317 CH NEt Q1e a bond H a bond NH O NH Q3c OH
    1318 CH NEt Q1e a bond H a bond NH O a bond Q3a OH
    1319 CH NEt Q1e a bond H a bond NH O a bond Q3b OH
    1320 CH NEt Q1e a bond H a bond NH O a bond Q3c OH
    1321 CH NEt Q1f a bond Me a bond NH S NH Q3a OH
    1322 CH NEt Q1f a bond Me a bond NH S NH Q3b OH
    1323 CH NEt Q1f a bond Me a bond NH S NH Q3c OH
    1324 CH NEt Q1f a bond Me a bond NH S a bond Q3a OH
    1325 CH NEt Q1f a bond Me a bond NH S a bond Q3b OH
    1326 CH NEt Q1f a bond Me a bond NH S a bond Q3c OH
    1327 CH NEt Q1f a bond Me a bond NH O NH Q3a OH
    1328 CH NEt Q1f a bond Me a bond NH O NH Q3b OH
    1329 CH NEt Q1f a bond Me a bond NH O NH Q3c OH
    1330 CH NEt Q1f a bond Me a bond NH O a bond Q3a OH
    1331 CH NEt Q1f a bond Me a bond NH O a bond Q3b OH
    1332 CH NEt Q1f a bond Me a bond NH O a bond Q3c OH
    1333 CH NEt Q1f a bond H a bond NH S NH Q3a OH
    1334 CH NEt Q1f a bond H a bond NH S NH Q3b OH
    1335 CH NEt Q1f a bond H a bond NH S NH Q3c OH
    1336 CH NEt Q1f a bond H a bond NH S a bond Q3a OH
    1337 CH NEt Q1f a bond H a bond NH S a bond Q3b OH
    1338 CH NEt Q1f a bond H a bond NH S a bond Q3c OH
    1339 CH NEt Q1f a bond H a bond NH O NH Q3a OH
    1340 CH NEt Q1f a bond H a bond NH O NH Q3b OH
    1341 CH NEt Q1f a bond H a bond NH O NH Q3c OH
    1342 CH NEt Q1f a bond H a bond NH O a bond Q3a OH
    1343 CH NEt Q1f a bond H a bond NH O a bond Q3b OH
    1344 CH NEt Q1f a bond H a bond NH O a bond Q3c OH
    1345 CH NEt Q1g a bond Me a bond NH S NH Q3a OH
    1346 CH NEt Q1g a bond Me a bond NH S NH Q3b OH
    1347 CH NEt Q1g a bond Me a bond NH S NH Q3c OH
    1348 CH NEt Q1g a bond Me a bond NH S a bond Q3a OH
    1349 CH NEt Q1g a bond Me a bond NH S a bond Q3b OH
    1350 CH NEt Q1g a bond Me a bond NH S a bond Q3c OH
    1351 CH NEt Q1g a bond Me a bond NH O NH Q3a OH
    1352 CH NEt Q1g a bond Me a bond NH O NH Q3b OH
    1353 CH NEt Q1g a bond Me a bond NH O NH Q3c OH
    1354 CH NEt Q1g a bond Me a bond NH O a bond Q3a OH
    1355 CH NEt Q1g a bond Me a bond NH O a bond Q3b OH
    1356 CH NEt Q1g a bond Me a bond NH O a bond Q3c OH
    1357 CH NEt Q1g a bond H a bond NH S NH Q3a OH
    1358 CH NEt Q1g a bond H a bond NH S NH Q3b OH
    1359 CH NEt Q1g a bond H a bond NH S NH Q3c OH
    1360 CH NEt Q1g a bond H a bond NH S a bond Q3a OH
    1361 CH NEt Q1g a bond H a bond NH S a bond Q3b OH
    1362 CH NEt Q1g a bond H a bond NH S a bond Q3c OH
    1363 CH NEt Q1g a bond H a bond NH O NH Q3a OH
    1364 CH NEt Q1g a bond H a bond NH O NH Q3b OH
    1365 CH NEt Q1g a bond H a bond NH O NH Q3c OH
    1366 CH NEt Q1g a bond H a bond NH O a bond Q3a OH
    1367 CH NEt Q1g a bond H a bond NH O a bond Q3b OH
    1368 CH NEt Q1g a bond H a bond NH O a bond Q3c OH
    1369 CH NEt Q1h a bond Me a bond NH S NH Q3a OH
    1370 CH NEt Q1h a bond Me a bond NH S NH Q3b OH
    1371 CH NEt Q1h a bond Me a bond NH S NH Q3c OH
    1372 CH NEt Q1h a bond Me a bond NH S a bond Q3a OH
    1373 CH NEt Q1h a bond Me a bond NH S a bond Q3b OH
    1374 CH NEt Q1h a bond Me a bond NH S a bond Q3c OH
    1375 CH NEt Q1h a bond Me a bond NH O NH Q3a OH
    1376 CH NEt Q1h a bond Me a bond NH O NH Q3b OH
    1377 CH NEt Q1h a bond Me a bond NH O NH Q3c OH
    1378 CH NEt Q1h a bond Me a bond NH O a bond Q3a OH
    1379 CH NEt Q1h a bond Me a bond NH O a bond Q3b OH
    1380 CH NEt Q1h a bond Me a bond NH O a bond Q3c OH
    1381 CH NEt Q1h a bond H a bond NH S NH Q3a OH
    1382 CH NEt Q1h a bond H a bond NH S NH Q3b OH
    1383 CH NEt Q1h a bond H a bond NH S NH Q3c OH
    1384 CH NEt Q1h a bond H a bond NH S a bond Q3a OH
    1385 CH NEt Q1h a bond H a bond NH S a bond Q3b OH
    1386 CH NEt Q1h a bond H a bond NH S a bond Q3c OH
    1387 CH NEt Q1h a bond H a bond NH O NH Q3a OH
    1388 CH NEt Q1h a bond H a bond NH O NH Q3b OH
    1389 CH NEt Q1h a bond H a bond NH O NH Q3c OH
    1390 CH NEt Q1h a bond H a bond NH O a bond Q3a OH
    1391 CH NEt Q1h a bond H a bond NH O a bond Q3b OH
    1392 CH NEt Q1h a bond H a bond NH O a bond Q3c OH
    1393 CH NEt Q1i a bond Me a bond NH S NH Q3a OH
    1394 CH NEt Q1i a bond Me a bond NH S NH Q3b OH
    1395 CH NEt Q1i a bond Me a bond NH S NH Q3c OH
    1396 CH NEt Q1i a bond Me a bond NH S a bond Q3a OH
    1397 CH NEt Q1i a bond Me a bond NH S a bond Q3b OH
    1398 CH NEt Q1i a bond Me a bond NH S a bond Q3c OH
    1399 CH NEt Q1i a bond Me a bond NH O NH Q3a OH
    1400 CH NEt Q1i a bond Me a bond NH O NH Q3b OH
    1401 CH NEt Q1i a bond Me a bond NH O NH Q3c OH
    1402 CH NEt Q1i a bond Me a bond NH O a bond Q3a OH
    1403 CH NEt Q1i a bond Me a bond NH O a bond Q3b OH
    1404 CH NEt Q1i a bond Me a bond NH O a bond Q3c OH
    1405 CH NEt Q1i a bond H a bond NH S NH Q3a OH
    1406 CH NEt Q1i a bond H a bond NH S NH Q3b OH
    1407 CH NEt Q1i a bond H a bond NH S NH Q3c OH
    1408 CH NEt Q1i a bond H a bond NH S a bond Q3a OH
    1409 CH NEt Q1i a bond H a bond NH S a bond Q3b OH
    1410 CH NEt Q1i a bond H a bond NH S a bond Q3c OH
    1411 CH NEt Q1i a bond H a bond NH O NH Q3a OH
    1412 CH NEt Q1i a bond H a bond NH O NH Q3b OH
    1413 CH NEt Q1i a bond H a bond NH O NH Q3c OH
    1414 CH NEt Q1i a bond H a bond NH O a bond Q3a OH
    1415 CH NEt Q1i a bond H a bond NH O a bond Q3b OH
    1416 CH NEt Q1i a bond H a bond NH O a bond Q3c OH
    1417 CH NEt Q1j a bond Me a bond NH S NH Q3a OH
    1418 CH NEt Q1j a bond Me a bond NH S NH Q3b OH
    1419 CH NEt Q1j a bond Me a bond NH S NH Q3c OH
    1420 CH NEt Q1j a bond Me a bond NH S a bond Q3a OH
    1421 CH NEt Q1j a bond Me a bond NH S a bond Q3b OH
    1422 CH NEt Q1j a bond Me a bond NH S a bond Q3c OH
    1423 CH NEt Q1j a bond Me a bond NH O NH Q3a OH
    1424 CH NEt Q1j a bond Me a bond NH O NH Q3b OH
    1425 CH NEt Q1j a bond Me a bond NH O NH Q3c OH
    1426 CH NEt Q1j a bond Me a bond NH O a bond Q3a OH
    1427 CH NEt Q1j a bond Me a bond NH O a bond Q3b OH
    1428 CH NEt Q1j a bond Me a bond NH O a bond Q3c OH
    1429 CH NEt Q1j a bond H a bond NH S NH Q3a OH
    1430 CH NEt Q1j a bond H a bond NH S NH Q3b OH
    1431 CH NEt Q1j a bond H a bond NH S NH Q3c OH
    1432 CH NEt Q1j a bond H a bond NH S a bond Q3a OH
    1433 CH NEt Q1j a bond H a bond NH S a bond Q3b OH
    1434 CH NEt Q1j a bond H a bond NH S a bond Q3c OH
    1435 CH NEt Q1j a bond H a bond NH O NH Q3a OH
    1436 CH NEt Q1j a bond H a bond NH O NH Q3b OH
    1437 CH NEt Q1j a bond H a bond NH O NH Q3c OH
    1438 CH NEt Q1j a bond H a bond NH O a bond Q3a OH
    1439 CH NEt Q1j a bond H a bond NH O a bond Q3b OH
    1440 CH NEt Q1j a bond H a bond NH O a bond Q3c OH
    1441 CH S Q1a a bond Me a bond NH S NH Q3a OH
    1442 CH S Q1a a bond Me a bond NH S NH Q3b OH
    1443 CH S Q1a a bond Me a bond NH S NH Q3c OH
    1444 CH S Q1a a bond Me a bond NH S a bond Q3a OH
    1445 CH S Q1a a bond Me a bond NH S a bond Q3b OH
    1446 CH S Q1a a bond Me a bond NH S a bond Q3c OH
    1447 CH S Q1a a bond Me a bond NH O NH Q3a OH
    1448 CH S Q1a a bond Me a bond NH O NH Q3b OH
    1449 CH S Q1a a bond Me a bond NH O NH Q3c OH
    1450 CH S Q1a a bond Me a bond NH O a bond Q3a OH
    1451 CH S Q1a a bond Me a bond NH O a bond Q3b OH
    1452 CH S Q1a a bond Me a bond NH O a bond Q3c OH
    1453 CH S Q1a a bond H a bond NH S NH Q3a OH
    1454 CH S Q1a a bond H a bond NH S NH Q3b OH
    1455 CH S Q1a a bond H a bond NH S NH Q3c OH
    1456 CH S Q1a a bond H a bond NH S a bond Q3a OH
    1457 CH S Q1a a bond H a bond NH S a bond Q3b OH
    1458 CH S Q1a a bond H a bond NH S a bond Q3c OH
    1459 CH S Q1a a bond H a bond NH O NH Q3a OH
    1460 CH S Q1a a bond H a bond NH O NH Q3b OH
    1461 CH S Q1a a bond H a bond NH O NH Q3c OH
    1462 CH S Q1a a bond H a bond NH O a bond Q3a OH
    1463 CH S Q1a a bond H a bond NH O a bond Q3b OH
    1464 CH S Q1a a bond H a bond NH O a bond Q3c OH
    1465 CH S Q1b a bond Me a bond NH S NH Q3a OH
    1466 CH S Q1b a bond Me a bond NH S NH Q3b OH
    1467 CH S Q1b a bond Me a bond NH S NH Q3c OH
    1468 CH S Q1b a bond Me a bond NH S a bond Q3a OH
    1469 CH S Q1b a bond Me a bond NH S a bond Q3b OH
    1470 CH S Q1b a bond Me a bond NH S a bond Q3c OH
    1471 CH S Q1b a bond Me a bond NH O NH Q3a OH
    1472 CH S Q1b a bond Me a bond NH O NH Q3b OH
    1473 CH S Q1b a bond Me a bond NH O NH Q3c OH
    1474 CH S Q1b a bond Me a bond NH O a bond Q3a OH
    1475 CH S Q1b a bond Me a bond NH O a bond Q3b OH
    1476 CH S Q1b a bond Me a bond NH O a bond Q3c OH
    1477 CH S Q1b a bond H a bond NH S NH Q3a OH
    1478 CH S Q1b a bond H a bond NH S NH Q3b OH
    1479 CH S Q1b a bond H a bond NH S NH Q3c OH
    1480 CH S Q1b a bond H a bond NH S a bond Q3a OH
    1481 CH S Q1b a bond H a bond NH S a bond Q3b OH
    1482 CH S Q1b a bond H a bond NH S a bond Q3c OH
    1483 CH S Q1b a bond H a bond NH O NH Q3a OH
    1484 CH S Q1b a bond H a bond NH O NH Q3b OH
    1485 CH S Q1b a bond H a bond NH O NH Q3c OH
    1486 CH S Q1b a bond H a bond NH O a bond Q3a OH
    1487 CH S Q1b a bond H a bond NH O a bond Q3b OH
    1488 CH S Q1b a bond H a bond NH O a bond Q3c OH
    1489 CH S Q1c a bond Me a bond NH S NH Q3a OH
    1490 CH S Q1c a bond Me a bond NH S NH Q3b OH
    1491 CH S Q1c a bond Me a bond NH S NH Q3c OH
    1492 CH S Q1c a bond Me a bond NH S a bond Q3a OH
    1493 CH S Q1c a bond Me a bond NH S a bond Q3b OH
    1494 CH S Q1c a bond Me a bond NH S a bond Q3c OH
    1495 CH S Q1c a bond Me a bond NH O NH Q3a OH
    1496 CH S Q1c a bond Me a bond NH O NH Q3b OH
    1497 CH S Q1c a bond Me a bond NH O NH Q3c OH
    1498 CH S Q1c a bond Me a bond NH O a bond Q3a OH
    1499 CH S Q1c a bond Me a bond NH O a bond Q3b OH
    1500 CH S Q1c a bond Me a bond NH O a bond Q3c OH
    1501 CH S Q1c a bond H a bond NH S NH Q3a OH
    1502 CH S Q1c a bond H a bond NH S NH Q3b OH
    1503 CH S Q1c a bond H a bond NH S NH Q3c OH
    1504 CH S Q1c a bond H a bond NH S a bond Q3a OH
    1505 CH S Q1c a bond H a bond NH S a bond Q3b OH
    1506 CH S Q1c a bond H a bond NH S a bond Q3c OH
    1507 CH S Q1c a bond H a bond NH O NH Q3a OH
    1508 CH S Q1c a bond H a bond NH O NH Q3b OH
    1509 CH S Q1c a bond H a bond NH O NH Q3c OH
    1510 CH S Q1c a bond H a bond NH O a bond Q3a OH
    1511 CH S Q1c a bond H a bond NH O a bond Q3b OH
    1512 CH S Q1c a bond H a bond NH O a bond Q3c OH
    1513 CH S Q1d a bond Me a bond NH S NH Q3a OH
    1514 CH S Q1d a bond Me a bond NH S NH Q3b OH
    1515 CH S Q1d a bond Me a bond NH S NH Q3c OH
    1516 CH S Q1d a bond Me a bond NH S a bond Q3a OH
    1517 CH S Q1d a bond Me a bond NH S a bond Q3b OH
    1518 CH S Q1d a bond Me a bond NH S a bond Q3c OH
    1519 CH S Q1d a bond Me a bond NH O NH Q3a OH
    1520 CH S Q1d a bond Me a bond NH O NH Q3b OH
    1521 CH S Q1d a bond Me a bond NH O NH Q3c OH
    1522 CH S Q1d a bond Me a bond NH O a bond Q3a OH
    1523 CH S Q1d a bond Me a bond NH O a bond Q3b OH
    1524 CH S Q1d a bond Me a bond NH O a bond Q3c OH
    1525 CH S Q1d a bond H a bond NH S NH Q3a OH
    1526 CH S Q1d a bond H a bond NH S NH Q3b OH
    1527 CH S Q1d a bond H a bond NH S NH Q3c OH
    1528 CH S Q1d a bond H a bond NH S a bond Q3a OH
    1529 CH S Q1d a bond H a bond NH S a bond Q3b OH
    1530 CH S Q1d a bond H a bond NH S a bond Q3c OH
    1531 CH S Q1d a bond H a bond NH O NH Q3a OH
    1532 CH S Q1d a bond H a bond NH O NH Q3b OH
    1533 CH S Q1d a bond H a bond NH O NH Q3c OH
    1534 CH S Q1d a bond H a bond NH O a bond Q3a OH
    1535 CH S Q1d a bond H a bond NH O a bond Q3b OH
    1536 CH S Q1d a bond H a bond NH O a bond Q3c OH
    1537 CH S Q1e a bond Me a bond NH S NH Q3a OH
    1538 CH S Q1e a bond Me a bond NH S NH Q3b OH
    1539 CH S Q1e a bond Me a bond NH S NH Q3c OH
    1540 CH S Q1e a bond Me a bond NH S a bond Q3a OH
    1541 CH S Q1e a bond Me a bond NH S a bond Q3b OH
    1542 CH S Q1e a bond Me a bond NH S a bond Q3c OH
    1543 CH S Q1e a bond Me a bond NH O NH Q3a OH
    1544 CH S Q1e a bond Me a bond NH O NH Q3b OH
    1545 CH S Q1e a bond Me a bond NH O NH Q3c OH
    1546 CH S Q1e a bond Me a bond NH O a bond Q3a OH
    1547 CH S Q1e a bond Me a bond NH O a bond Q3b OH
    1548 CH S Q1e a bond Me a bond NH O a bond Q3c OH
    1549 CH S Q1e a bond H a bond NH S NH Q3a OH
    1550 CH S Q1e a bond H a bond NH S NH Q3b OH
    1551 CH S Q1e a bond H a bond NH S NH Q3c OH
    1552 CH S Q1e a bond H a bond NH S a bond Q3a OH
    1553 CH S Q1e a bond H a bond NH S a bond Q3b OH
    1554 CH S Q1e a bond H a bond NH S a bond Q3c OH
    1555 CH S Q1e a bond H a bond NH O NH Q3a OH
    1556 CH S Q1e a bond H a bond NH O NH Q3b OH
    1557 CH S Q1e a bond H a bond NH O NH Q3c OH
    1558 CH S Q1e a bond H a bond NH O a bond Q3a OH
    1559 CH S Q1e a bond H a bond NH O a bond Q3b OH
    1560 CH S Q1e a bond H a bond NH O a bond Q3c OH
    1561 CH S Q1f a bond Me a bond NH S NH Q3a OH
    1562 CH S Q1f a bond Me a bond NH S NH Q3b OH
    1563 CH S Q1f a bond Me a bond NH S NH Q3c OH
    1564 CH S Q1f a bond Me a bond NH S a bond Q3a OH
    1565 CH S Q1f a bond Me a bond NH S a bond Q3b OH
    1566 CH S Q1f a bond Me a bond NH S a bond Q3c OH
    1567 CH S Q1f a bond Me a bond NH O NH Q3a OH
    1568 CH S Q1f a bond Me a bond NH O NH Q3b OH
    1569 CH S Q1f a bond Me a bond NH O NH Q3c OH
    1570 CH S Q1f a bond Me a bond NH O a bond Q3a OH
    1571 CH S Q1f a bond Me a bond NH O a bond Q3b OH
    1572 CH S Q1f a bond Me a bond NH O a bond Q3c OH
    1573 CH S Q1f a bond H a bond NH S NH Q3a OH
    1574 CH S Q1f a bond H a bond NH S NH Q3b OH
    1575 CH S Q1f a bond H a bond NH S NH Q3c OH
    1576 CH S Q1f a bond H a bond NH S a bond Q3a OH
    1577 CH S Q1f a bond H a bond NH S a bond Q3b OH
    1578 CH S Q1f a bond H a bond NH S a bond Q3c OH
    1579 CH S Q1f a bond H a bond NH O NH Q3a OH
    1580 CH S Q1f a bond H a bond NH O NH Q3b OH
    1581 CH S Q1f a bond H a bond NH O NH Q3c OH
    1582 CH S Q1f a bond H a bond NH O a bond Q3a OH
    1583 CH S Q1f a bond H a bond NH O a bond Q3b OH
    1584 CH S Q1f a bond H a bond NH O a bond Q3c OH
    1585 CH S Q1g a bond Me a bond NH S NH Q3a OH
    1586 CH S Q1g a bond Me a bond NH S NH Q3b OH
    1587 CH S Q1g a bond Me a bond NH S NH Q3c OH
    1588 CH S Q1g a bond Me a bond NH S a bond Q3a OH
    1589 CH S Q1g a bond Me a bond NH S a bond Q3b OH
    1590 CH S Q1g a bond Me a bond NH S a bond Q3c OH
    1591 CH S Q1g a bond Me a bond NH O NH Q3a OH
    1592 CH S Q1g a bond Me a bond NH O NH Q3b OH
    1593 CH S Q1g a bond Me a bond NH O NH Q3c OH
    1594 CH S Q1g a bond Me a bond NH O a bond Q3a OH
    1595 CH S Q1g a bond Me a bond NH O a bond Q3b OH
    1596 CH S Q1g a bond Me a bond NH O a bond Q3c OH
    1597 CH S Q1g a bond H a bond NH S NH Q3a OH
    1598 CH S Q1g a bond H a bond NH S NH Q3b OH
    1599 CH S Q1g a bond H a bond NH S NH Q3c OH
    1600 CH S Q1g a bond H a bond NH S a bond Q3a OH
    1601 CH S Q1g a bond H a bond NH S a bond Q3b OH
    1602 CH S Q1g a bond H a bond NH S a bond Q3c OH
    1603 CH S Q1g a bond H a bond NH O NH Q3a OH
    1604 CH S Q1g a bond H a bond NH O NH Q3b OH
    1605 CH S Q1g a bond H a bond NH O NH Q3c OH
    1606 CH S Q1g a bond H a bond NH O a bond Q3a OH
    1607 CH S Q1g a bond H a bond NH O a bond Q3b OH
    1608 CH S Q1g a bond H a bond NH O a bond Q3c OH
    1609 CH S Q1h a bond Me a bond NH S NH Q3a OH
    1610 CH S Q1h a bond Me a bond NH S NH Q3b OH
    1611 CH S Q1h a bond Me a bond NH S NH Q3c OH
    1612 CH S Q1h a bond Me a bond NH S a bond Q3a OH
    1613 CH S Q1h a bond Me a bond NH S a bond Q3b OH
    1614 CH S Q1h a bond Me a bond NH S a bond Q3c OH
    1615 CH S Q1h a bond Me a bond NH O NH Q3a OH
    1616 CH S Q1h a bond Me a bond NH O NH Q3b OH
    1617 CH S Q1h a bond Me a bond NH O NH Q3c OH
    1618 CH S Q1h a bond Me a bond NH O a bond Q3a OH
    1619 CH S Q1h a bond Me a bond NH O a bond Q3b OH
    1620 CH S Q1h a bond Me a bond NH O a bond Q3c OH
    1621 CH S Q1h a bond H a bond NH S NH Q3a OH
    1622 CH S Q1h a bond H a bond NH S NH Q3b OH
    1623 CH S Q1h a bond H a bond NH S NH Q3c OH
    1624 CH S Q1h a bond H a bond NH S a bond Q3a OH
    1625 CH S Q1h a bond H a bond NH S a bond Q3b OH
    1626 CH S Q1h a bond H a bond NH S a bond Q3c OH
    1627 CH S Q1h a bond H a bond NH O NH Q3a OH
    1628 CH S Q1h a bond H a bond NH O NH Q3b OH
    1629 CH S Q1h a bond H a bond NH O NH Q3c OH
    1630 CH S Q1h a bond H a bond NH O a bond Q3a OH
    1631 CH S Q1h a bond H a bond NH O a bond Q3b OH
    1632 CH S Q1h a bond H a bond NH O a bond Q3c OH
    1633 CH S Q1i a bond Me a bond NH S NH Q3a OH
    1634 CH S Q1i a bond Me a bond NH S NH Q3b OH
    1635 CH S Q1i a bond Me a bond NH S NH Q3c OH
    1636 CH S Q1i a bond Me a bond NH S a bond Q3a OH
    1637 CH S Q1i a bond Me a bond NH S a bond Q3b OH
    1638 CH S Q1i a bond Me a bond NH S a bond Q3c OH
    1639 CH S Q1i a bond Me a bond NH O NH Q3a OH
    1640 CH S Q1i a bond Me a bond NH O NH Q3b OH
    1641 CH S Q1i a bond Me a bond NH O NH Q3c OH
    1642 CH S Q1i a bond Me a bond NH O a bond Q3a OH
    1643 CH S Q1i a bond Me a bond NH O a bond Q3b OH
    1644 CH S Q1i a bond Me a bond NH O a bond Q3c OH
    1645 CH S Q1i a bond H a bond NH S NH Q3a OH
    1646 CH S Q1i a bond H a bond NH S NH Q3b OH
    1647 CH S Q1i a bond H a bond NH S NH Q3c OH
    1648 CH S Q1i a bond H a bond NH S a bond Q3a OH
    1649 CH S Q1i a bond H a bond NH S a bond Q3b OH
    1650 CH S Q1i a bond H a bond NH S a bond Q3c OH
    1651 CH S Q1i a bond H a bond NH O NH Q3a OH
    1652 CH S Q1i a bond H a bond NH O NH Q3b OH
    1653 CH S Q1i a bond H a bond NH O NH Q3c OH
    1654 CH S Q1i a bond H a bond NH O a bond Q3a OH
    1655 CH S Q1i a bond H a bond NH O a bond Q3b OH
    1656 CH S Q1i a bond H a bond NH O a bond Q3c OH
    1657 CH S Q1j a bond Me a bond NH S NH Q3a OH
    1658 CH S Q1j a bond Me a bond NH S NH Q3b OH
    1659 CH S Q1j a bond Me a bond NH S NH Q3c OH
    1660 CH S Q1j a bond Me a bond NH S a bond Q3a OH
    1661 CH S Q1j a bond Me a bond NH S a bond Q3b OH
    1662 CH S Q1j a bond Me a bond NH S a bond Q3c OH
    1663 CH S Q1j a bond Me a bond NH O NH Q3a OH
    1664 CH S Q1j a bond Me a bond NH O NH Q3b OH
    1665 CH S Q1j a bond Me a bond NH O NH Q3c OH
    1666 CH S Q1j a bond Me a bond NH O a bond Q3a OH
    1667 CH S Q1j a bond Me a bond NH O a bond Q3b OH
    1668 CH S Q1j a bond Me a bond NH O a bond Q3c OH
    1669 CH S Q1j a bond H a bond NH S NH Q3a OH
    1670 CH S Q1j a bond H a bond NH S NH Q3b OH
    1671 CH S Q1j a bond H a bond NH S NH Q3c OH
    1672 CH S Q1j a bond H a bond NH S a bond Q3a OH
    1673 CH S Q1j a bond H a bond NH S a bond Q3b OH
    1674 CH S Q1j a bond H a bond NH S a bond Q3c OH
    1675 CH S Q1j a bond H a bond NH O NH Q3a OH
    1676 CH S Q1j a bond H a bond NH O NH Q3b OH
    1677 CH S Q1j a bond H a bond NH O NH Q3c OH
    1678 CH S Q1j a bond H a bond NH O a bond Q3a OH
    1679 CH S Q1j a bond H a bond NH O a bond Q3b OH
    1680 CH S Q1j a bond H a bond NH O a bond Q3c OH
    1681 CH O Q1a a bond Me a bond NH S NH Q3a OH
    1682 CH O Q1a a bond Me a bond NH S NH Q3b OH
    1683 CH O Q1a a bond Me a bond NH S NH Q3c OH
    1684 CH O Q1a a bond Me a bond NH S a bond Q3a OH
    1685 CH O Q1a a bond Me a bond NH S a bond Q3b OH
    1686 CH O Q1a a bond Me a bond NH S a bond Q3c OH
    1687 CH O Q1a a bond Me a bond NH O NH Q3a OH
    1688 CH O Q1a a bond Me a bond NH O NH Q3b OH
    1689 CH O Q1a a bond Me a bond NH O NH Q3c OH
    1690 CH O Q1a a bond Me a bond NH O a bond Q3a OH
    1691 CH O Q1a a bond Me a bond NH O a bond Q3b OH
    1692 CH O Q1a a bond Me a bond NH O a bond Q3c OH
    1693 CH O Q1a a bond H a bond NH S NH Q3a OH
    1694 CH O Q1a a bond H a bond NH S NH Q3b OH
    1695 CH O Q1a a bond H a bond NH S NH Q3c OH
    1696 CH O Q1a a bond H a bond NH S a bond Q3a OH
    1697 CH O Q1a a bond H a bond NH S a bond Q3b OH
    1698 CH O Q1a a bond H a bond NH S a bond Q3c OH
    1699 CH O Q1a a bond H a bond NH O NH Q3a OH
    1700 CH O Q1a a bond H a bond NH O NH Q3b OH
    1701 CH O Q1a a bond H a bond NH O NH Q3c OH
    1702 CH O Q1a a bond H a bond NH O a bond Q3a OH
    1703 CH O Q1a a bond H a bond NH O a bond Q3b OH
    1704 CH O Q1a a bond H a bond NH O a bond Q3c OH
    1705 CH O Q1b a bond Me a bond NH S NH Q3a OH
    1706 CH O Q1b a bond Me a bond NH S NH Q3b OH
    1707 CH O Q1b a bond Me a bond NH S NH Q3c OH
    1708 CH O Q1b a bond Me a bond NH S a bond Q3a OH
    1709 CH O Q1b a bond Me a bond NH S a bond Q3b OH
    1710 CH O Q1b a bond Me a bond NH S a bond Q3c OH
    1711 CH O Q1b a bond Me a bond NH O NH Q3a OH
    1712 CH O Q1b a bond Me a bond NH O NH Q3b OH
    1713 CH O Q1b a bond Me a bond NH O NH Q3c OH
    1714 CH O Q1b a bond Me a bond NH O a bond Q3a OH
    1715 CH O Q1b a bond Me a bond NH O a bond Q3b OH
    1716 CH O Q1b a bond Me a bond NH O a bond Q3c OH
    1717 CH O Q1b a bond H a bond NH S NH Q3a OH
    1718 CH O Q1b a bond H a bond NH S NH Q3b OH
    1719 CH O Q1b a bond H a bond NH S NH Q3c OH
    1720 CH O Q1b a bond H a bond NH S a bond Q3a OH
    1721 CH O Q1b a bond H a bond NH S a bond Q3b OH
    1722 CH O Q1b a bond H a bond NH S a bond Q3c OH
    1723 CH O Q1b a bond H a bond NH O NH Q3a OH
    1724 CH O Q1b a bond H a bond NH O NH Q3b OH
    1725 CH O Q1b a bond H a bond NH O NH Q3c OH
    1726 CH O Q1b a bond H a bond NH O a bond Q3a OH
    1727 CH O Q1b a bond H a bond NH O a bond Q3b OH
    1728 CH O Q1b a bond H a bond NH O a bond Q3c OH
    1729 CH O Q1c a bond Me a bond NH S NH Q3a OH
    1730 CH O Q1c a bond Me a bond NH S NH Q3b OH
    1731 CH O Q1c a bond Me a bond NH S NH Q3c OH
    1732 CH O Q1c a bond Me a bond NH S a bond Q3a OH
    1733 CH O Q1c a bond Me a bond NH S a bond Q3b OH
    1734 CH O Q1c a bond Me a bond NH S a bond Q3c OH
    1735 CH O Q1c a bond Me a bond NH O NH Q3a OH
    1736 CH O Q1c a bond Me a bond NH O NH Q3b OH
    1737 CH O Q1c a bond Me a bond NH O NH Q3c OH
    1738 CH O Q1c a bond Me a bond NH O a bond Q3a OH
    1739 CH O Q1c a bond Me a bond NH O a bond Q3b OH
    1740 CH O Q1c a bond Me a bond NH O a bond Q3c OH
    1741 CH O Q1c a bond H a bond NH S NH Q3a OH
    1742 CH O Q1c a bond H a bond NH S NH Q3b OH
    1743 CH O Q1c a bond H a bond NH S NH Q3c OH
    1744 CH O Q1c a bond H a bond NH S a bond Q3a OH
    1745 CH O Q1c a bond H a bond NH S a bond Q3b OH
    1746 CH O Q1c a bond H a bond NH S a bond Q3c OH
    1747 CH O Q1c a bond H a bond NH O NH Q3a OH
    1748 CH O Q1c a bond H a bond NH O NH Q3b OH
    1749 CH O Q1c a bond H a bond NH O NH Q3c OH
    1750 CH O Q1c a bond H a bond NH O a bond Q3a OH
    1751 CH O Q1c a bond H a bond NH O a bond Q3b OH
    1752 CH O Q1c a bond H a bond NH O a bond Q3c OH
    1753 CH O Q1d a bond Me a bond NH S NH Q3a OH
    1754 CH O Q1d a bond Me a bond NH S NH Q3b OH
    1755 CH O Q1d a bond Me a bond NH S NH Q3c OH
    1756 CH O Q1d a bond Me a bond NH S a bond Q3a OH
    1757 CH O Q1d a bond Me a bond NH S a bond Q3b OH
    1758 CH O Q1d a bond Me a bond NH S a bond Q3c OH
    1759 CH O Q1d a bond Me a bond NH O NH Q3a OH
    1760 CH O Q1d a bond Me a bond NH O NH Q3b OH
    1761 CH O Q1d a bond Me a bond NH O NH Q3c OH
    1762 CH O Q1d a bond Me a bond NH O a bond Q3a OH
    1763 CH O Q1d a bond Me a bond NH O a bond Q3b OH
    1764 CH O Q1d a bond Me a bond NH O a bond Q3c OH
    1765 CH O Q1d a bond H a bond NH S NH Q3a OH
    1766 CH O Q1d a bond H a bond NH S NH Q3b OH
    1767 CH O Q1d a bond H a bond NH S NH Q3c OH
    1768 CH O Q1d a bond H a bond NH S a bond Q3a OH
    1769 CH O Q1d a bond H a bond NH S a bond Q3b OH
    1770 CH O Q1d a bond H a bond NH S a bond Q3c OH
    1771 CH O Q1d a bond H a bond NH O NH Q3a OH
    1772 CH O Q1d a bond H a bond NH O NH Q3b OH
    1773 CH O Q1d a bond H a bond NH O NH Q3c OH
    1774 CH O Q1d a bond H a bond NH O a bond Q3a OH
    1775 CH O Q1d a bond H a bond NH O a bond Q3b OH
    1776 CH O Q1d a bond H a bond NH O a bond Q3c OH
    1777 CH O Q1e a bond Me a bond NH S NH Q3a OH
    1778 CH O Q1e a bond Me a bond NH S NH Q3b OH
    1779 CH O Q1e a bond Me a bond NH S NH Q3c OH
    1780 CH O Q1e a bond Me a bond NH S a bond Q3a OH
    1781 CH O Q1e a bond Me a bond NH S a bond Q3b OH
    1782 CH O Q1e a bond Me a bond NH S a bond Q3c OH
    1783 CH O Q1e a bond Me a bond NH O NH Q3a OH
    1784 CH O Q1e a bond Me a bond NH O NH Q3b OH
    1785 CH O Q1e a bond Me a bond NH O NH Q3c OH
    1786 CH O Q1e a bond Me a bond NH O a bond Q3a OH
    1787 CH O Q1e a bond Me a bond NH O a bond Q3b OH
    1788 CH O Q1e a bond Me a bond NH O a bond Q3c OH
    1789 CH O Q1e a bond H a bond NH S NH Q3a OH
    1790 CH O Q1e a bond H a bond NH S NH Q3b OH
    1791 CH O Q1e a bond H a bond NH S NH Q3c OH
    1792 CH O Q1e a bond H a bond NH S a bond Q3a OH
    1793 CH O Q1e a bond H a bond NH S a bond Q3b OH
    1794 CH O Q1e a bond H a bond NH S a bond Q3c OH
    1795 CH O Q1e a bond H a bond NH O NH Q3a OH
    1796 CH O Q1e a bond H a bond NH O NH Q3b OH
    1797 CH O Q1e a bond H a bond NH O NH Q3c OH
    1798 CH O Q1e a bond H a bond NH O a bond Q3a OH
    1799 CH O Q1e a bond H a bond NH O a bond Q3b OH
    1800 CH O Q1e a bond H a bond NH O a bond Q3c OH
    1801 CH O Q1f a bond Me a bond NH S NH Q3a OH
    1802 CH O Q1f a bond Me a bond NH S NH Q3b OH
    1803 CH O Q1f a bond Me a bond NH S NH Q3c OH
    1804 CH O Q1f a bond Me a bond NH S a bond Q3a OH
    1805 CH O Q1f a bond Me a bond NH S a bond Q3b OH
    1806 CH O Q1f a bond Me a bond NH S a bond Q3c OH
    1807 CH O Q1f a bond Me a bond NH O NH Q3a OH
    1808 CH O Q1f a bond Me a bond NH O NH Q3b OH
    1809 CH O Q1f a bond Me a bond NH O NH Q3c OH
    1810 CH O Q1f a bond Me a bond NH O a bond Q3a OH
    1811 CH O Q1f a bond Me a bond NH O a bond Q3b OH
    1812 CH O Q1f a bond Me a bond NH O a bond Q3c OH
    1813 CH O Q1f a bond H a bond NH S NH Q3a OH
    1814 CH O Q1f a bond H a bond NH S NH Q3b OH
    1815 CH O Q1f a bond H a bond NH S NH Q3c OH
    1816 CH O Q1f a bond H a bond NH S a bond Q3a OH
    1817 CH O Q1f a bond H a bond NH S a bond Q3b OH
    1818 CH O Q1f a bond H a bond NH S a bond Q3c OH
    1819 CH O Q1f a bond H a bond NH O NH Q3a OH
    1820 CH O Q1f a bond H a bond NH O NH Q3b OH
    1821 CH O Q1f a bond H a bond NH O NH Q3c OH
    1822 CH O Q1f a bond H a bond NH O a bond Q3a OH
    1823 CH O Q1f a bond H a bond NH O a bond Q3b OH
    1824 CH O Q1f a bond H a bond NH O a bond Q3c OH
    1825 CH O Q1g a bond Me a bond NH S NH Q3a OH
    1826 CH O Q1g a bond Me a bond NH S NH Q3b OH
    1827 CH O Q1g a bond Me a bond NH S NH Q3c OH
    1828 CH O Q1g a bond Me a bond NH S a bond Q3a OH
    1829 CH O Q1g a bond Me a bond NH S a bond Q3b OH
    1830 CH O Q1g a bond Me a bond NH S a bond Q3c OH
    1831 CH O Q1g a bond Me a bond NH O NH Q3a OH
    1832 CH O Q1g a bond Me a bond NH O NH Q3b OH
    1833 CH O Q1g a bond Me a bond NH O NH Q3c OH
    1834 CH O Q1g a bond Me a bond NH O a bond Q3a OH
    1835 CH O Q1g a bond Me a bond NH O a bond Q3b OH
    1836 CH O Q1g a bond Me a bond NH O a bond Q3c OH
    1837 CH O Q1g a bond H a bond NH S NH Q3a OH
    1838 CH O Q1g a bond H a bond NH S NH Q3b OH
    1839 CH O Q1g a bond H a bond NH S NH Q3c OH
    1840 CH O Q1g a bond H a bond NH S a bond Q3a OH
    1841 CH O Q1g a bond H a bond NH S a bond Q3b OH
    1842 CH O Q1g a bond H a bond NH S a bond Q3c OH
    1843 CH O Q1g a bond H a bond NH O NH Q3a OH
    1844 CH O Q1g a bond H a bond NH O NH Q3b OH
    1845 CH O Q1g a bond H a bond NH O NH Q3c OH
    1846 CH O Q1g a bond H a bond NH O a bond Q3a OH
    1847 CH O Q1g a bond H a bond NH O a bond Q3b OH
    1848 CH O Q1g a bond H a bond NH O a bond Q3c OH
    1849 CH O Q1h a bond Me a bond NH S NH Q3a OH
    1850 CH O Q1h a bond Me a bond NH S NH Q3b OH
    1851 CH O Q1h a bond Me a bond NH S NH Q3c OH
    1852 CH O Q1h a bond Me a bond NH S a bond Q3a OH
    1853 CH O Q1h a bond Me a bond NH S a bond Q3b OH
    1854 CH O Q1h a bond Me a bond NH S a bond Q3c OH
    1855 CH O Q1h a bond Me a bond NH O NH Q3a OH
    1856 CH O Q1h a bond Me a bond NH O NH Q3b OH
    1857 CH O Q1h a bond Me a bond NH O NH Q3c OH
    1858 CH O Q1h a bond Me a bond NH O a bond Q3a OH
    1859 CH O Q1h a bond Me a bond NH O a bond Q3b OH
    1860 CH O Q1h a bond Me a bond NH O a bond Q3c OH
    1861 CH O Q1h a bond H a bond NH S NH Q3a OH
    1862 CH O Q1h a bond H a bond NH S NH Q3b OH
    1863 CH O Q1h a bond H a bond NH S NH Q3c OH
    1864 CH O Q1h a bond H a bond NH S a bond Q3a OH
    1865 CH O Q1h a bond H a bond NH S a bond Q3b OH
    1866 CH O Q1h a bond H a bond NH S a bond Q3c OH
    1867 CH O Q1h a bond H a bond NH O NH Q3a OH
    1868 CH O Q1h a bond H a bond NH O NH Q3b OH
    1869 CH O Q1h a bond H a bond NH O NH Q3c OH
    1870 CH O Q1h a bond H a bond NH O a bond Q3a OH
    1871 CH O Q1h a bond H a bond NH O a bond Q3b OH
    1872 CH O Q1h a bond H a bond NH O a bond Q3c OH
    1873 CH O Q1i a bond Me a bond NH S NH Q3a OH
    1874 CH O Q1i a bond Me a bond NH S NH Q3b OH
    1875 CH O Q1i a bond Me a bond NH S NH Q3c OH
    1876 CH O Q1i a bond Me a bond NH S a bond Q3a OH
    1877 CH O Q1i a bond Me a bond NH S a bond Q3b OH
    1878 CH O Q1i a bond Me a bond NH S a bond Q3c OH
    1879 CH O Q1i a bond Me a bond NH O NH Q3a OH
    1880 CH O Q1i a bond Me a bond NH O NH Q3b OH
    1881 CH O Q1i a bond Me a bond NH O NH Q3c OH
    1882 CH O Q1i a bond Me a bond NH O a bond Q3a OH
    1883 CH O Q1i a bond Me a bond NH O a bond Q3b OH
    1884 CH O Q1i a bond Me a bond NH O a bond Q3c OH
    1885 CH O Q1i a bond H a bond NH S NH Q3a OH
    1886 CH O Q1i a bond H a bond NH S NH Q3b OH
    1887 CH O Q1i a bond H a bond NH S NH Q3c OH
    1888 CH O Q1i a bond H a bond NH S a bond Q3a OH
    1889 CH O Q1i a bond H a bond NH S a bond Q3b OH
    1890 CH O Q1i a bond H a bond NH S a bond Q3c OH
    1891 CH O Q1i a bond H a bond NH O NH Q3a OH
    1892 CH O Q1i a bond H a bond NH O NH Q3b OH
    1893 CH O Q1i a bond H a bond NH O NH Q3c OH
    1894 CH O Q1i a bond H a bond NH O a bond Q3a OH
    1895 CH O Q1i a bond H a bond NH O a bond Q3b OH
    1896 CH O Q1i a bond H a bond NH O a bond Q3c OH
    1897 CH O Q1j a bond Me a bond NH S NH Q3a OH
    1898 CH O Q1j a bond Me a bond NH S NH Q3b OH
    1899 CH O Q1j a bond Me a bond NH S NH Q3c OH
    1900 CH O Q1j a bond Me a bond NH S a bond Q3a OH
    1901 CH O Q1j a bond Me a bond NH S a bond Q3b OH
    1902 CH O Q1j a bond Me a bond NH S a bond Q3c OH
    1903 CH O Q1j a bond Me a bond NH O NH Q3a OH
    1904 CH O Q1j a bond Me a bond NH O NH Q3b OH
    1905 CH O Q1j a bond Me a bond NH O NH Q3c OH
    1906 CH O Q1j a bond Me a bond NH O a bond Q3a OH
    1907 CH O Q1j a bond Me a bond NH O a bond Q3b OH
    1908 CH O Q1j a bond Me a bond NH O a bond Q3c OH
    1909 CH O Q1j a bond H a bond NH S NH Q3a OH
    1910 CH O Q1j a bond H a bond NH S NH Q3b OH
    1911 CH O Q1j a bond H a bond NH S NH Q3c OH
    1912 CH O Q1j a bond H a bond NH S a bond Q3a OH
    1913 CH O Q1j a bond H a bond NH S a bond Q3b OH
    1914 CH O Q1j a bond H a bond NH S a bond Q3c OH
    1915 CH O Q1j a bond H a bond NH O NH Q3a OH
    1916 CH O Q1j a bond H a bond NH O NH Q3b OH
    1917 CH O Q1j a bond H a bond NH O NH Q3c OH
    1918 CH O Q1j a bond H a bond NH O a bond Q3a OH
    1919 CH O Q1j a bond H a bond NH O a bond Q3b OH
    1920 CH O Q1j a bond H a bond NH O a bond Q3c OH
    1921 CMe NMe Q1a a bond Me a bond NH S NH Q3a OH
    1922 CMe NMe Q1a a bond Me a bond NH S NH Q3b OH
    1923 CMe NMe Q1a a bond Me a bond NH S NH Q3c OH
    1924 CMe NMe Q1a a bond Me a bond NH S a bond Q3a OH
    1925 CMe NMe Q1a a bond Me a bond NH S a bond Q3b OH
    1926 CMe NMe Q1a a bond Me a bond NH S a bond Q3c OH
    1927 CMe NMe Q1a a bond Me a bond NH O NH Q3a OH
    1928 CMe NMe Q1a a bond Me a bond NH O NH Q3b OH
    1929 CMe NMe Q1a a bond Me a bond NH O NH Q3c OH
    1930 CMe NMe Q1a a bond Me a bond NH O a bond Q3a OH
    1931 CMe NMe Q1a a bond Me a bond NH O a bond Q3b OH
    1932 CMe NMe Q1a a bond Me a bond NH O a bond Q3c OH
    1933 CMe NMe Q1a a bond H a bond NH S NH Q3a OH
    1934 CMe NMe Q1a a bond H a bond NH S NH Q3b OH
    1935 CMe NMe Q1a a bond H a bond NH S NH Q3c OH
    1936 CMe NMe Q1a a bond H a bond NH S a bond Q3a OH
    1937 CMe NMe Q1a a bond H a bond NH S a bond Q3b OH
    1938 CMe NMe Q1a a bond H a bond NH S a bond Q3c OH
    1939 CMe NMe Q1a a bond H a bond NH O NH Q3a OH
    1940 CMe NMe Q1a a bond H a bond NH O NH Q3b OH
    1941 CMe NMe Q1a a bond H a bond NH O NH Q3c OH
    1942 CMe NMe Q1a a bond H a bond NH O a bond Q3a OH
    1943 CMe NMe Q1a a bond H a bond NH O a bond Q3b OH
    1944 CMe NMe Q1a a bond H a bond NH O a bond Q3c OH
    1945 CMe NMe Q1b a bond Me a bond NH S NH Q3a OH
    1946 CMe NMe Q1b a bond Me a bond NH S NH Q3b OH
    1947 CMe NMe Q1b a bond Me a bond NH S NH Q3c OH
    1948 CMe NMe Q1b a bond Me a bond NH S a bond Q3a OH
    1949 CMe NMe Q1b a bond Me a bond NH S a bond Q3b OH
    1950 CMe NMe Q1b a bond Me a bond NH S a bond Q3c OH
    1951 CMe NMe Q1b a bond Me a bond NH O NH Q3a OH
    1952 CMe NMe Q1b a bond Me a bond NH O NH Q3b OH
    1953 CMe NMe Q1b a bond Me a bond NH O NH Q3c OH
    1954 CMe NMe Q1b a bond Me a bond NH O a bond Q3a OH
    1955 CMe NMe Q1b a bond Me a bond NH O a bond Q3b OH
    1956 CMe NMe Q1b a bond Me a bond NH O a bond Q3c OH
    1957 CMe NMe Q1b a bond H a bond NH S NH Q3a OH
    1958 CMe NMe Q1b a bond H a bond NH S NH Q3b OH
    1959 CMe NMe Q1b a bond H a bond NH S NH Q3c OH
    1960 CMe NMe Q1b a bond H a bond NH S a bond Q3a OH
    1961 CMe NMe Q1b a bond H a bond NH S a bond Q3b OH
    1962 CMe NMe Q1b a bond H a bond NH S a bond Q3c OH
    1963 CMe NMe Q1b a bond H a bond NH O NH Q3a OH
    1964 CMe NMe Q1b a bond H a bond NH O NH Q3b OH
    1965 CMe NMe Q1b a bond H a bond NH O NH Q3c OH
    1966 CMe NMe Q1b a bond H a bond NH O a bond Q3a OH
    1967 CMe NMe Q1b a bond H a bond NH O a bond Q3b OH
    1968 CMe NMe Q1b a bond H a bond NH O a bond Q3c OH
    1969 CMe NMe Q1c a bond Me a bond NH S NH Q3a OH
    1970 CMe NMe Q1c a bond Me a bond NH S NH Q3b OH
    1971 CMe NMe Q1c a bond Me a bond NH S NH Q3c OH
    1972 CMe NMe Q1c a bond Me a bond NH S a bond Q3a OH
    1973 CMe NMe Q1c a bond Me a bond NH S a bond Q3b OH
    1974 CMe NMe Q1c a bond Me a bond NH S a bond Q3c OH
    1975 CMe NMe Q1c a bond Me a bond NH O NH Q3a OH
    1976 CMe NMe Q1c a bond Me a bond NH O NH Q3b OH
    1977 CMe NMe Q1c a bond Me a bond NH O NH Q3c OH
    1978 CMe NMe Q1c a bond Me a bond NH O a bond Q3a OH
    1979 CMe NMe Q1c a bond Me a bond NH O a bond Q3b OH
    1980 CMe NMe Q1c a bond Me a bond NH O a bond Q3c OH
    1981 CMe NMe Q1c a bond H a bond NH S NH Q3a OH
    1982 CMe NMe Q1c a bond H a bond NH S NH Q3b OH
    1983 CMe NMe Q1c a bond H a bond NH S NH Q3c OH
    1984 CMe NMe Q1c a bond H a bond NH S a bond Q3a OH
    1985 CMe NMe Q1c a bond H a bond NH S a bond Q3b OH
    1986 CMe NMe Q1c a bond H a bond NH S a bond Q3c OH
    1987 CMe NMe Q1c a bond H a bond NH O NH Q3a OH
    1988 CMe NMe Q1c a bond H a bond NH O NH Q3b OH
    1989 CMe NMe Q1c a bond H a bond NH O NH Q3c OH
    1990 CMe NMe Q1c a bond H a bond NH O a bond Q3a OH
    1991 CMe NMe Q1c a bond H a bond NH O a bond Q3b OH
    1992 CMe NMe Q1c a bond H a bond NH O a bond Q3c OH
    1993 CMe NMe Q1d a bond Me a bond NH S NH Q3a OH
    1994 CMe NMe Q1d a bond Me a bond NH S NH Q3b OH
    1995 CMe NMe Q1d a bond Me a bond NH S NH Q3c OH
    1996 CMe NMe Q1d a bond Me a bond NH S a bond Q3a OH
    1997 CMe NMe Q1d a bond Me a bond NH S a bond Q3b OH
    1998 CMe NMe Q1d a bond Me a bond NH S a bond Q3c OH
    1999 CMe NMe Q1d a bond Me a bond NH O NH Q3a OH
    2000 CMe NMe Q1d a bond Me a bond NH O NH Q3b OH
    2001 CMe NMe Q1d a bond Me a bond NH O NH Q3c OH
    2002 CMe NMe Q1d a bond Me a bond NH O a bond Q3a OH
    2003 CMe NMe Q1d a bond Me a bond NH O a bond Q3b OH
    2004 CMe NMe Q1d a bond Me a bond NH O a bond Q3c OH
    2005 CMe NMe Q1d a bond H a bond NH S NH Q3a OH
    2006 CMe NMe Q1d a bond H a bond NH S NH Q3b OH
    2007 CMe NMe Q1d a bond H a bond NH S NH Q3c OH
    2008 CMe NMe Q1d a bond H a bond NH S a bond Q3a OH
    2009 CMe NMe Q1d a bond H a bond NH S a bond Q3b OH
    2010 CMe NMe Q1d a bond H a bond NH S a bond Q3c OH
    2011 CMe NMe Q1d a bond H a bond NH O NH Q3a OH
    2012 CMe NMe Q1d a bond H a bond NH O NH Q3b OH
    2013 CMe NMe Q1d a bond H a bond NH O NH Q3c OH
    2014 CMe NMe Q1d a bond H a bond NH O a bond Q3a OH
    2015 CMe NMe Q1d a bond H a bond NH O a bond Q3b OH
    2016 CMe NMe Q1d a bond H a bond NH O a bond Q3c OH
    2017 CMe NMe Q1e a bond Me a bond NH S NH Q3a OH
    2018 CMe NMe Q1e a bond Me a bond NH S NH Q3b OH
    2019 CMe NMe Q1e a bond Me a bond NH S NH Q3c OH
    2020 CMe NMe Q1e a bond Me a bond NH S a bond Q3a OH
    2021 CMe NMe Q1e a bond Me a bond NH S a bond Q3b OH
    2022 CMe NMe Q1e a bond Me a bond NH S a bond Q3c OH
    2023 CMe NMe Q1e a bond Me a bond NH O NH Q3a OH
    2024 CMe NMe Q1e a bond Me a bond NH O NH Q3b OH
    2025 CMe NMe Q1e a bond Me a bond NH O NH Q3c OH
    2026 CMe NMe Q1e a bond Me a bond NH O a bond Q3a OH
    2027 CMe NMe Q1e a bond Me a bond NH O a bond Q3b OH
    2028 CMe NMe Q1e a bond Me a bond NH O a bond Q3c OH
    2029 CMe NMe Q1e a bond H a bond NH S NH Q3a OH
    2030 CMe NMe Q1e a bond H a bond NH S NH Q3b OH
    2031 CMe NMe Q1e a bond H a bond NH S NH Q3c OH
    2032 CMe NMe Q1e a bond H a bond NH S a bond Q3a OH
    2033 CMe NMe Q1e a bond H a bond NH S a bond Q3b OH
    2034 CMe NMe Q1e a bond H a bond NH S a bond Q3c OH
    2035 CMe NMe Q1e a bond H a bond NH O NH Q3a OH
    2036 CMe NMe Q1e a bond H a bond NH O NH Q3b OH
    2037 CMe NMe Q1e a bond H a bond NH O NH Q3c OH
    2038 CMe NMe Q1e a bond H a bond NH O a bond Q3a OH
    2039 CMe NMe Q1e a bond H a bond NH O a bond Q3b OH
    2040 CMe NMe Q1e a bond H a bond NH O a bond Q3c OH
    2041 CMe NMe Q1f a bond Me a bond NH S NH Q3a OH
    2042 CMe NMe Q1f a bond Me a bond NH S NH Q3b OH
    2043 CMe NMe Q1f a bond Me a bond NH S NH Q3c OH
    2044 CMe NMe Q1f a bond Me a bond NH S a bond Q3a OH
    2045 CMe NMe Q1f a bond Me a bond NH S a bond Q3b OH
    2046 CMe NMe Q1f a bond Me a bond NH S a bond Q3c OH
    2047 CMe NMe Q1f a bond Me a bond NH O NH Q3a OH
    2048 CMe NMe Q1f a bond Me a bond NH O NH Q3b OH
    2049 CMe NMe Q1f a bond Me a bond NH O NH Q3c OH
    2050 CMe NMe Q1f a bond Me a bond NH O a bond Q3a OH
    2051 CMe NMe Q1f a bond Me a bond NH O a bond Q3b OH
    2052 CMe NMe Q1f a bond Me a bond NH O a bond Q3c OH
    2053 CMe NMe Q1f a bond H a bond NH S NH Q3a OH
    2054 CMe NMe Q1f a bond H a bond NH S NH Q3b OH
    2055 CMe NMe Q1f a bond H a bond NH S NH Q3c OH
    2056 CMe NMe Q1f a bond H a bond NH S a bond Q3a OH
    2057 CMe NMe Q1f a bond H a bond NH S a bond Q3b OH
    2058 CMe NMe Q1f a bond H a bond NH S a bond Q3c OH
    2059 CMe NMe Q1f a bond H a bond NH O NH Q3a OH
    2060 CMe NMe Q1f a bond H a bond NH O NH Q3b OH
    2061 CMe NMe Q1f a bond H a bond NH O NH Q3c OH
    2062 CMe NMe Q1f a bond H a bond NH O a bond Q3a OH
    2063 CMe NMe Q1f a bond H a bond NH O a bond Q3b OH
    2064 CMe NMe Q1f a bond H a bond NH O a bond Q3c OH
    2065 CMe NMe Q1g a bond Me a bond NH S NH Q3a OH
    2066 CMe NMe Q1g a bond Me a bond NH S NH Q3b OH
    2067 CMe NMe Q1g a bond Me a bond NH S NH Q3c OH
    2068 CMe NMe Q1g a bond Me a bond NH S a bond Q3a OH
    2069 CMe NMe Q1g a bond Me a bond NH S a bond Q3b OH
    2070 CMe NMe Q1g a bond Me a bond NH S a bond Q3c OH
    2071 CMe NMe Q1g a bond Me a bond NH O NH Q3a OH
    2072 CMe NMe Q1g a bond Me a bond NH O NH Q3b OH
    2073 CMe NMe Q1g a bond Me a bond NH O NH Q3c OH
    2074 CMe NMe Q1g a bond Me a bond NH O a bond Q3a OH
    2075 CMe NMe Q1g a bond Me a bond NH O a bond Q3b OH
    2076 CMe NMe Q1g a bond Me a bond NH O a bond Q3c OH
    2077 CMe NMe Q1g a bond H a bond NH S NH Q3a OH
    2078 CMe NMe Q1g a bond H a bond NH S NH Q3b OH
    2079 CMe NMe Q1g a bond H a bond NH S NH Q3c OH
    2080 CMe NMe Q1g a bond H a bond NH S a bond Q3a OH
    2081 CMe NMe Q1g a bond H a bond NH S a bond Q3b OH
    2082 CMe NMe Q1g a bond H a bond NH S a bond Q3c OH
    2083 CMe NMe Q1g a bond H a bond NH O NH Q3a OH
    2084 CMe NMe Q1g a bond H a bond NH O NH Q3b OH
    2085 CMe NMe Q1g a bond H a bond NH O NH Q3c OH
    2086 CMe NMe Q1g a bond H a bond NH O a bond Q3a OH
    2087 CMe NMe Q1g a bond H a bond NH O a bond Q3b OH
    2088 CMe NMe Q1g a bond H a bond NH O a bond Q3c OH
    2089 CMe NMe Q1h a bond Me a bond NH S NH Q3a OH
    2090 CMe NMe Q1h a bond Me a bond NH S NH Q3b OH
    2091 CMe NMe Q1h a bond Me a bond NH S NH Q3c OH
    2092 CMe NMe Q1h a bond Me a bond NH S a bond Q3a OH
    2093 CMe NMe Q1h a bond Me a bond NH S a bond Q3b OH
    2094 CMe NMe Q1h a bond Me a bond NH S a bond Q3c OH
    2095 CMe NMe Q1h a bond Me a bond NH O NH Q3a OH
    2096 CMe NMe Q1h a bond Me a bond NH O NH Q3b OH
    2097 CMe NMe Q1h a bond Me a bond NH O NH Q3c OH
    2098 CMe NMe Q1h a bond Me a bond NH O a bond Q3a OH
    2099 CMe NMe Q1h a bond Me a bond NH O a bond Q3b OH
    2100 CMe NMe Q1h a bond Me a bond NH O a bond Q3c OH
    2101 CMe NMe Q1h a bond H a bond NH S NH Q3a OH
    2102 CMe NMe Q1h a bond H a bond NH S NH Q3b OH
    2103 CMe NMe Q1h a bond H a bond NH S NH Q3c OH
    2104 CMe NMe Q1h a bond H a bond NH S a bond Q3a OH
    2105 CMe NMe Q1h a bond H a bond NH S a bond Q3b OH
    2106 CMe NMe Q1h a bond H a bond NH S a bond Q3c OH
    2107 CMe NMe Q1h a bond H a bond NH O NH Q3a OH
    2108 CMe NMe Q1h a bond H a bond NH O NH Q3b OH
    2109 CMe NMe Q1h a bond H a bond NH O NH Q3c OH
    2110 CMe NMe Q1h a bond H a bond NH O a bond Q3a OH
    2111 CMe NMe Q1h a bond H a bond NH O a bond Q3b OH
    2112 CMe NMe Q1h a bond H a bond NH O a bond Q3c OH
    2113 CMe NMe Q1i a bond Me a bond NH S NH Q3a OH
    2114 CMe NMe Q1i a bond Me a bond NH S NH Q3b OH
    2115 CMe NMe Q1i a bond Me a bond NH S NH Q3c OH
    2116 CMe NMe Q1i a bond Me a bond NH S a bond Q3a OH
    2117 CMe NMe Q1i a bond Me a bond NH S a bond Q3b OH
    2118 CMe NMe Q1i a bond Me a bond NH S a bond Q3c OH
    2119 CMe NMe Q1i a bond Me a bond NH O NH Q3a OH
    2120 CMe NMe Q1i a bond Me a bond NH O NH Q3b OH
    2121 CMe NMe Q1i a bond Me a bond NH O NH Q3c OH
    2122 CMe NMe Q1i a bond Me a bond NH O a bond Q3a OH
    2123 CMe NMe Q1i a bond Me a bond NH O a bond Q3b OH
    2124 CMe NMe Q1i a bond Me a bond NH O a bond Q3c OH
    2125 CMe NMe Q1i a bond H a bond NH S NH Q3a OH
    2126 CMe NMe Q1i a bond H a bond NH S NH Q3b OH
    2127 CMe NMe Q1i a bond H a bond NH S NH Q3c OH
    2128 CMe NMe Q1i a bond H a bond NH S a bond Q3a OH
    2129 CMe NMe Q1i a bond H a bond NH S a bond Q3b OH
    2130 CMe NMe Q1i a bond H a bond NH S a bond Q3c OH
    2131 CMe NMe Q1i a bond H a bond NH O NH Q3a OH
    2132 CMe NMe Q1i a bond H a bond NH O NH Q3b OH
    2133 CMe NMe Q1i a bond H a bond NH O NH Q3c OH
    2134 CMe NMe Q1i a bond H a bond NH O a bond Q3a OH
    2135 CMe NMe Q1i a bond H a bond NH O a bond Q3b OH
    2136 CMe NMe Q1i a bond H a bond NH O a bond Q3c OH
    2137 CMe NMe Q1j a bond Me a bond NH S NH Q3a OH
    2138 CMe NMe Q1j a bond Me a bond NH S NH Q3b OH
    2139 CMe NMe Q1j a bond Me a bond NH S NH Q3c OH
    2140 CMe NMe Q1j a bond Me a bond NH S a bond Q3a OH
    2141 CMe NMe Q1j a bond Me a bond NH S a bond Q3b OH
    2142 CMe NMe Q1j a bond Me a bond NH S a bond Q3c OH
    2143 CMe NMe Q1j a bond Me a bond NH O NH Q3a OH
    2144 CMe NMe Q1j a bond Me a bond NH O NH Q3b OH
    2145 CMe NMe Q1j a bond Me a bond NH O NH Q3c OH
    2146 CMe NMe Q1j a bond Me a bond NH O a bond Q3a OH
    2147 CMe NMe Q1j a bond Me a bond NH O a bond Q3b OH
    2148 CMe NMe Q1j a bond Me a bond NH O a bond Q3c OH
    2149 CMe NMe Q1j a bond H a bond NH S NH Q3a OH
    2150 CMe NMe Q1j a bond H a bond NH S NH Q3b OH
    2151 CMe NMe Q1j a bond H a bond NH S NH Q3c OH
    2152 CMe NMe Q1j a bond H a bond NH S a bond Q3a OH
    2153 CMe NMe Q1j a bond H a bond NH S a bond Q3b OH
    2154 CMe NMe Q1j a bond H a bond NH S a bond Q3c OH
    2155 CMe NMe Q1j a bond H a bond NH O NH Q3a OH
    2156 CMe NMe Q1j a bond H a bond NH O NH Q3b OH
    2157 CMe NMe Q1j a bond H a bond NH O NH Q3c OH
    2158 CMe NMe Q1j a bond H a bond NH O a bond Q3a OH
    2159 CMe NMe Q1j a bond H a bond NH O a bond Q3b OH
    2160 CMe NMe Q1j a bond H a bond NH O a bond Q3c OH
    2161 CMe NEt Q1a a bond Me a bond NH S NH Q3a OH
    2162 CMe NEt Q1a a bond Me a bond NH S NH Q3b OH
    2163 CMe NEt Q1a a bond Me a bond NH S NH Q3c OH
    2164 CMe NEt Q1a a bond Me a bond NH S a bond Q3a OH
    2165 CMe NEt Q1a a bond Me a bond NH S a bond Q3b OH
    2166 CMe NEt Q1a a bond Me a bond NH S a bond Q3c OH
    2167 CMe NEt Q1a a bond Me a bond NH O NH Q3a OH
    2168 CMe NEt Q1a a bond Me a bond NH O NH Q3b OH
    2169 CMe NEt Q1a a bond Me a bond NH O NH Q3c OH
    2170 CMe NEt Q1a a bond Me a bond NH O a bond Q3a OH
    2171 CMe NEt Q1a a bond Me a bond NH O a bond Q3b OH
    2172 CMe NEt Q1a a bond Me a bond NH O a bond Q3c OH
    2173 CMe NEt Q1a a bond H a bond NH S NH Q3a OH
    2174 CMe NEt Q1a a bond H a bond NH S NH Q3b OH
    2175 CMe NEt Q1a a bond H a bond NH S NH Q3c OH
    2176 CMe NEt Q1a a bond H a bond NH S a bond Q3a OH
    2177 CMe NEt Q1a a bond H a bond NH S a bond Q3b OH
    2178 CMe NEt Q1a a bond H a bond NH S a bond Q3c OH
    2179 CMe NEt Q1a a bond H a bond NH O NH Q3a OH
    2180 CMe NEt Q1a a bond H a bond NH O NH Q3b OH
    2181 CMe NEt Q1a a bond H a bond NH O NH Q3c OH
    2182 CMe NEt Q1a a bond H a bond NH O a bond Q3a OH
    2183 CMe NEt Q1a a bond H a bond NH O a bond Q3b OH
    2184 CMe NEt Q1a a bond H a bond NH O a bond Q3c OH
    2185 CMe NEt Q1b a bond Me a bond NH S NH Q3a OH
    2186 CMe NEt Q1b a bond Me a bond NH S NH Q3b OH
    2187 CMe NEt Q1b a bond Me a bond NH S NH Q3c OH
    2188 CMe NEt Q1b a bond Me a bond NH S a bond Q3a OH
    2189 CMe NEt Q1b a bond Me a bond NH S a bond Q3b OH
    2190 CMe NEt Q1b a bond Me a bond NH S a bond Q3c OH
    2191 CMe NEt Q1b a bond Me a bond NH O NH Q3a OH
    2192 CMe NEt Q1b a bond Me a bond NH O NH Q3b OH
    2193 CMe NEt Q1b a bond Me a bond NH O NH Q3c OH
    2194 CMe NEt Q1b a bond Me a bond NH O a bond Q3a OH
    2195 CMe NEt Q1b a bond Me a bond NH O a bond Q3b OH
    2196 CMe NEt Q1b a bond Me a bond NH O a bond Q3c OH
    2197 CMe NEt Q1b a bond H a bond NH S NH Q3a OH
    2198 CMe NEt Q1b a bond H a bond NH S NH Q3b OH
    2199 CMe NEt Q1b a bond H a bond NH S NH Q3c OH
    2200 CMe NEt Q1b a bond H a bond NH S a bond Q3a OH
    2201 CMe NEt Q1b a bond H a bond NH S a bond Q3b OH
    2202 CMe NEt Q1b a bond H a bond NH S a bond Q3c OH
    2203 CMe NEt Q1b a bond H a bond NH O NH Q3a OH
    2204 CMe NEt Q1b a bond H a bond NH O NH Q3b OH
    2205 CMe NEt Q1b a bond H a bond NH O NH Q3c OH
    2206 CMe NEt Q1b a bond H a bond NH O a bond Q3a OH
    2207 CMe NEt Q1b a bond H a bond NH O a bond Q3b OH
    2208 CMe NEt Q1b a bond H a bond NH O a bond Q3c OH
    2209 CMe NEt Q1c a bond Me a bond NH S NH Q3a OH
    2210 CMe NEt Q1c a bond Me a bond NH S NH Q3b OH
    2211 CMe NEt Q1c a bond Me a bond NH S NH Q3c OH
    2212 CMe NEt Q1c a bond Me a bond NH S a bond Q3a OH
    2213 CMe NEt Q1c a bond Me a bond NH S a bond Q3b OH
    2214 CMe NEt Q1c a bond Me a bond NH S a bond Q3c OH
    2215 CMe NEt Q1c a bond Me a bond NH O NH Q3a OH
    2216 CMe NEt Q1c a bond Me a bond NH O NH Q3b OH
    2217 CMe NEt Q1c a bond Me a bond NH O NH Q3c OH
    2218 CMe NEt Q1c a bond Me a bond NH O a bond Q3a OH
    2219 CMe NEt Q1c a bond Me a bond NH O a bond Q3b OH
    2220 CMe NEt Q1c a bond Me a bond NH O a bond Q3c OH
    2221 CMe NEt Q1c a bond H a bond NH S NH Q3a OH
    2222 CMe NEt Q1c a bond H a bond NH S NH Q3b OH
    2223 CMe NEt Q1c a bond H a bond NH S NH Q3c OH
    2224 CMe NEt Q1c a bond H a bond NH S a bond Q3a OH
    2225 CMe NEt Q1c a bond H a bond NH S a bond Q3b OH
    2226 CMe NEt Q1c a bond H a bond NH S a bond Q3c OH
    2227 CMe NEt Q1c a bond H a bond NH O NH Q3a OH
    2228 CMe NEt Q1c a bond H a bond NH O NH Q3b OH
    2229 CMe NEt Q1c a bond H a bond NH O NH Q3c OH
    2230 CMe NEt Q1c a bond H a bond NH O a bond Q3a OH
    2231 CMe NEt Q1c a bond H a bond NH O a bond Q3b OH
    2232 CMe NEt Q1c a bond H a bond NH O a bond Q3c OH
    2233 CMe NEt Q1d a bond Me a bond NH S NH Q3a OH
    2234 CMe NEt Q1d a bond Me a bond NH S NH Q3b OH
    2235 CMe NEt Q1d a bond Me a bond NH S NH Q3c OH
    2236 CMe NEt Q1d a bond Me a bond NH S a bond Q3a OH
    2237 CMe NEt Q1d a bond Me a bond NH S a bond Q3b OH
    2238 CMe NEt Q1d a bond Me a bond NH S a bond Q3c OH
    2239 CMe NEt Q1d a bond Me a bond NH O NH Q3a OH
    2240 CMe NEt Q1d a bond Me a bond NH O NH Q3b OH
    2241 CMe NEt Q1d a bond Me a bond NH O NH Q3c OH
    2242 CMe NEt Q1d a bond Me a bond NH O a bond Q3a OH
    2243 CMe NEt Q1d a bond Me a bond NH O a bond Q3b OH
    2244 CMe NEt Q1d a bond Me a bond NH O a bond Q3c OH
    2245 CMe NEt Q1d a bond H a bond NH S NH Q3a OH
    2246 CMe NEt Q1d a bond H a bond NH S NH Q3b OH
    2247 CMe NEt Q1d a bond H a bond NH S NH Q3c OH
    2248 CMe NEt Q1d a bond H a bond NH S a bond Q3a OH
    2249 CMe NEt Q1d a bond H a bond NH S a bond Q3b OH
    2250 CMe NEt Q1d a bond H a bond NH S a bond Q3c OH
    2251 CMe NEt Q1d a bond H a bond NH O NH Q3a OH
    2252 CMe NEt Q1d a bond H a bond NH O NH Q3b OH
    2253 CMe NEt Q1d a bond H a bond NH O NH Q3c OH
    2254 CMe NEt Q1d a bond H a bond NH O a bond Q3a OH
    2255 CMe NEt Q1d a bond H a bond NH O a bond Q3b OH
    2256 CMe NEt Q1d a bond H a bond NH O a bond Q3c OH
    2257 CMe NEt Q1e a bond Me a bond NH S NH Q3a OH
    2258 CMe NEt Q1e a bond Me a bond NH S NH Q3b OH
    2259 CMe NEt Q1e a bond Me a bond NH S NH Q3c OH
    2260 CMe NEt Q1e a bond Me a bond NH S a bond Q3a OH
    2261 CMe NEt Q1e a bond Me a bond NH S a bond Q3b OH
    2262 CMe NEt Q1e a bond Me a bond NH S a bond Q3c OH
    2263 CMe NEt Q1e a bond Me a bond NH O NH Q3a OH
    2264 CMe NEt Q1e a bond Me a bond NH O NH Q3b OH
    2265 CMe NEt Q1e a bond Me a bond NH O NH Q3c OH
    2266 CMe NEt Q1e a bond Me a bond NH O a bond Q3a OH
    2267 CMe NEt Q1e a bond Me a bond NH O a bond Q3b OH
    2268 CMe NEt Q1e a bond Me a bond NH O a bond Q3c OH
    2269 CMe NEt Q1e a bond H a bond NH S NH Q3a OH
    2270 CMe NEt Q1e a bond H a bond NH S NH Q3b OH
    2271 CMe NEt Q1e a bond H a bond NH S NH Q3c OH
    2272 CMe NEt Q1e a bond H a bond NH S a bond Q3a OH
    2273 CMe NEt Q1e a bond H a bond NH S a bond Q3b OH
    2274 CMe NEt Q1e a bond H a bond NH S a bond Q3c OH
    2275 CMe NEt Q1e a bond H a bond NH O NH Q3a OH
    2276 CMe NEt Q1e a bond H a bond NH O NH Q3b OH
    2277 CMe NEt Q1e a bond H a bond NH O NH Q3c OH
    2278 CMe NEt Q1e a bond H a bond NH O a bond Q3a OH
    2279 CMe NEt Q1e a bond H a bond NH O a bond Q3b OH
    2280 CMe NEt Q1e a bond H a bond NH O a bond Q3c OH
    2281 CMe NEt Q1f a bond Me a bond NH S NH Q3a OH
    2282 CMe NEt Q1f a bond Me a bond NH S NH Q3b OH
    2283 CMe NEt Q1f a bond Me a bond NH S NH Q3c OH
    2284 CMe NEt Q1f a bond Me a bond NH S a bond Q3a OH
    2285 CMe NEt Q1f a bond Me a bond NH S a bond Q3b OH
    2286 CMe NEt Q1f a bond Me a bond NH S a bond Q3c OH
    2287 CMe NEt Q1f a bond Me a bond NH O NH Q3a OH
    2288 CMe NEt Q1f a bond Me a bond NH O NH Q3b OH
    2289 CMe NEt Q1f a bond Me a bond NH O NH Q3c OH
    2290 CMe NEt Q1f a bond Me a bond NH O a bond Q3a OH
    2291 CMe NEt Q1f a bond Me a bond NH O a bond Q3b OH
    2292 CMe NEt Q1f a bond Me a bond NH O a bond Q3c OH
    2293 CMe NEt Q1f a bond H a bond NH S NH Q3a OH
    2294 CMe NEt Q1f a bond H a bond NH S NH Q3b OH
    2295 CMe NEt Q1f a bond H a bond NH S NH Q3c OH
    2296 CMe NEt Q1f a bond H a bond NH S a bond Q3a OH
    2297 CMe NEt Q1f a bond H a bond NH S a bond Q3b OH
    2298 CMe NEt Q1f a bond H a bond NH S a bond Q3c OH
    2299 CMe NEt Q1f a bond H a bond NH O NH Q3a OH
    2300 CMe NEt Q1f a bond H a bond NH O NH Q3b OH
    2301 CMe NEt Q1f a bond H a bond NH O NH Q3c OH
    2302 CMe NEt Q1f a bond H a bond NH O a bond Q3a OH
    2303 CMe NEt Q1f a bond H a bond NH O a bond Q3b OH
    2304 CMe NEt Q1f a bond H a bond NH O a bond Q3c OH
    2305 CMe NEt Q1g a bond Me a bond NH S NH Q3a OH
    2306 CMe NEt Q1g a bond Me a bond NH S NH Q3b OH
    2307 CMe NEt Q1g a bond Me a bond NH S NH Q3c OH
    2308 CMe NEt Q1g a bond Me a bond NH S a bond Q3a OH
    2309 CMe NEt Q1g a bond Me a bond NH S a bond Q3b OH
    2310 CMe NEt Q1g a bond Me a bond NH S a bond Q3c OH
    2311 CMe NEt Q1g a bond Me a bond NH O NH Q3a OH
    2312 CMe NEt Q1g a bond Me a bond NH O NH Q3b OH
    2313 CMe NEt Q1g a bond Me a bond NH O NH Q3c OH
    2314 CMe NEt Q1g a bond Me a bond NH O a bond Q3a OH
    2315 CMe NEt Q1g a bond Me a bond NH O a bond Q3b OH
    2316 CMe NEt Q1g a bond Me a bond NH O a bond Q3c OH
    2317 CMe NEt Q1g a bond H a bond NH S NH Q3a OH
    2318 CMe NEt Q1g a bond H a bond NH S NH Q3b OH
    2319 CMe NEt Q1g a bond H a bond NH S NH Q3c OH
    2320 CMe NEt Q1g a bond H a bond NH S a bond Q3a OH
    2321 CMe NEt Q1g a bond H a bond NH S a bond Q3b OH
    2322 CMe NEt Q1g a bond H a bond NH S a bond Q3c OH
    2323 CMe NEt Q1g a bond H a bond NH O NH Q3a OH
    2324 CMe NEt Q1g a bond H a bond NH O NH Q3b OH
    2325 CMe NEt Q1g a bond H a bond NH O NH Q3c OH
    2326 CMe NEt Q1g a bond H a bond NH O a bond Q3a OH
    2327 CMe NEt Q1g a bond H a bond NH O a bond Q3b OH
    2328 CMe NEt Q1g a bond H a bond NH O a bond Q3c OH
    2329 CMe NEt Q1h a bond Me a bond NH S NH Q3a OH
    2330 CMe NEt Q1h a bond Me a bond NH S NH Q3b OH
    2331 CMe NEt Q1h a bond Me a bond NH S NH Q3c OH
    2332 CMe NEt Q1h a bond Me a bond NH S a bond Q3a OH
    2333 CMe NEt Q1h a bond Me a bond NH S a bond Q3b OH
    2334 CMe NEt Q1h a bond Me a bond NH S a bond Q3c OH
    2335 CMe NEt Q1h a bond Me a bond NH O NH Q3a OH
    2336 CMe NEt Q1h a bond Me a bond NH O NH Q3b OH
    2337 CMe NEt Q1h a bond Me a bond NH O NH Q3c OH
    2338 CMe NEt Q1h a bond Me a bond NH O a bond Q3a OH
    2339 CMe NEt Q1h a bond Me a bond NH O a bond Q3b OH
    2340 CMe NEt Q1h a bond Me a bond NH O a bond Q3c OH
    2341 CMe NEt Q1h a bond H a bond NH S NH Q3a OH
    2342 CMe NEt Q1h a bond H a bond NH S NH Q3b OH
    2343 CMe NEt Q1h a bond H a bond NH S NH Q3c OH
    2344 CMe NEt Q1h a bond H a bond NH S a bond Q3a OH
    2345 CMe NEt Q1h a bond H a bond NH S a bond Q3b OH
    2346 CMe NEt Q1h a bond H a bond NH S a bond Q3c OH
    2347 CMe NEt Q1h a bond H a bond NH O NH Q3a OH
    2348 CMe NEt Q1h a bond H a bond NH O NH Q3b OH
    2349 CMe NEt Q1h a bond H a bond NH O NH Q3c OH
    2350 CMe NEt Q1h a bond H a bond NH O a bond Q3a OH
    2351 CMe NEt Q1h a bond H a bond NH O a bond Q3b OH
    2352 CMe NEt Q1h a bond H a bond NH O a bond Q3c OH
    2353 CMe NEt Q1i a bond Me a bond NH S NH Q3a OH
    2354 CMe NEt Q1i a bond Me a bond NH S NH Q3b OH
    2355 CMe NEt Q1i a bond Me a bond NH S NH Q3c OH
    2356 CMe NEt Q1i a bond Me a bond NH S a bond Q3a OH
    2357 CMe NEt Q1i a bond Me a bond NH S a bond Q3b OH
    2358 CMe NEt Q1i a bond Me a bond NH S a bond Q3c OH
    2359 CMe NEt Q1i a bond Me a bond NH O NH Q3a OH
    2360 CMe NEt Q1i a bond Me a bond NH O NH Q3b OH
    2361 CMe NEt Q1i a bond Me a bond NH O NH Q3c OH
    2362 CMe NEt Q1i a bond Me a bond NH O a bond Q3a OH
    2363 CMe NEt Q1i a bond Me a bond NH O a bond Q3b OH
    2364 CMe NEt Q1i a bond Me a bond NH O a bond Q3c OH
    2365 CMe NEt Q1i a bond H a bond NH S NH Q3a OH
    2366 CMe NEt Q1i a bond H a bond NH S NH Q3b OH
    2367 CMe NEt Q1i a bond H a bond NH S NH Q3c OH
    2368 CMe NEt Q1i a bond H a bond NH S a bond Q3a OH
    2369 CMe NEt Q1i a bond H a bond NH S a bond Q3b OH
    2370 CMe NEt Q1i a bond H a bond NH S a bond Q3c OH
    2371 CMe NEt Q1i a bond H a bond NH O NH Q3a OH
    2372 CMe NEt Q1i a bond H a bond NH O NH Q3b OH
    2373 CMe NEt Q1i a bond H a bond NH O NH Q3c OH
    2374 CMe NEt Q1i a bond H a bond NH O a bond Q3a OH
    2375 CMe NEt Q1i a bond H a bond NH O a bond Q3b OH
    2376 CMe NEt Q1i a bond H a bond NH O a bond Q3c OH
    2377 CMe NEt Q1j a bond Me a bond NH S NH Q3a OH
    2378 CMe NEt Q1j a bond Me a bond NH S NH Q3b OH
    2379 CMe NEt Q1j a bond Me a bond NH S NH Q3c OH
    2380 CMe NEt Q1j a bond Me a bond NH S a bond Q3a OH
    2381 CMe NEt Q1j a bond Me a bond NH S a bond Q3b OH
    2382 CMe NEt Q1j a bond Me a bond NH S a bond Q3c OH
    2383 CMe NEt Q1j a bond Me a bond NH O NH Q3a OH
    2384 CMe NEt Q1j a bond Me a bond NH O NH Q3b OH
    2385 CMe NEt Q1j a bond Me a bond NH O NH Q3c OH
    2386 CMe NEt Q1j a bond Me a bond NH O a bond Q3a OH
    2387 CMe NEt Q1j a bond Me a bond NH O a bond Q3b OH
    2388 CMe NEt Q1j a bond Me a bond NH O a bond Q3c OH
    2389 CMe NEt Q1j a bond H a bond NH S NH Q3a OH
    2390 CMe NEt Q1j a bond H a bond NH S NH Q3b OH
    2391 CMe NEt Q1j a bond H a bond NH S NH Q3c OH
    2392 CMe NEt Q1j a bond H a bond NH S a bond Q3a OH
    2393 CMe NEt Q1j a bond H a bond NH S a bond Q3b OH
    2394 CMe NEt Q1j a bond H a bond NH S a bond Q3c OH
    2395 CMe NEt Q1j a bond H a bond NH O NH Q3a OH
    2396 CMe NEt Q1j a bond H a bond NH O NH Q3b OH
    2397 CMe NEt Q1j a bond H a bond NH O NH Q3c OH
    2398 CMe NEt Q1j a bond H a bond NH O a bond Q3a OH
    2399 CMe NEt Q1j a bond H a bond NH O a bond Q3b OH
    2400 CMe NEt Q1j a bond H a bond NH O a bond Q3c OH
    2401 CMe S Q1a a bond Me a bond NH S NH Q3a OH
    2402 CMe S Q1a a bond Me a bond NH S NH Q3b OH
    2403 CMe S Q1a a bond Me a bond NH S NH Q3c OH
    2404 CMe S Q1a a bond Me a bond NH S a bond Q3a OH
    2405 CMe S Q1a a bond Me a bond NH S a bond Q3b OH
    2406 CMe S Q1a a bond Me a bond NH S a bond Q3c OH
    2407 CMe S Q1a a bond Me a bond NH O NH Q3a OH
    2408 CMe S Q1a a bond Me a bond NH O NH Q3b OH
    2409 CMe S Q1a a bond Me a bond NH O NH Q3c OH
    2410 CMe S Q1a a bond Me a bond NH O a bond Q3a OH
    2411 CMe S Q1a a bond Me a bond NH O a bond Q3b OH
    2412 CMe S Q1a a bond Me a bond NH O a bond Q3c OH
    2413 CMe S Q1a a bond H a bond NH S NH Q3a OH
    2414 CMe S Q1a a bond H a bond NH S NH Q3b OH
    2415 CMe S Q1a a bond H a bond NH S NH Q3c OH
    2416 CMe S Q1a a bond H a bond NH S a bond Q3a OH
    2417 CMe S Q1a a bond H a bond NH S a bond Q3b OH
    2418 CMe S Q1a a bond H a bond NH S a bond Q3c OH
    2419 CMe S Q1a a bond H a bond NH O NH Q3a OH
    2420 CMe S Q1a a bond H a bond NH O NH Q3b OH
    2421 CMe S Q1a a bond H a bond NH O NH Q3c OH
    2422 CMe S Q1a a bond H a bond NH O a bond Q3a OH
    2423 CMe S Q1a a bond H a bond NH O a bond Q3b OH
    2424 CMe S Q1a a bond H a bond NH O a bond Q3c OH
    2425 CMe S Q1b a bond Me a bond NH S NH Q3a OH
    2426 CMe S Q1b a bond Me a bond NH S NH Q3b OH
    2427 CMe S Q1b a bond Me a bond NH S NH Q3c OH
    2428 CMe S Q1b a bond Me a bond NH S a bond Q3a OH
    2429 CMe S Q1b a bond Me a bond NH S a bond Q3b OH
    2430 CMe S Q1b a bond Me a bond NH S a bond Q3c OH
    2431 CMe S Q1b a bond Me a bond NH O NH Q3a OH
    2432 CMe S Q1b a bond Me a bond NH O NH Q3b OH
    2433 CMe S Q1b a bond Me a bond NH O NH Q3c OH
    2434 CMe S Q1b a bond Me a bond NH O a bond Q3a OH
    2435 CMe S Q1b a bond Me a bond NH O a bond Q3b OH
    2436 CMe S Q1b a bond Me a bond NH O a bond Q3c OH
    2437 CMe S Q1b a bond H a bond NH S NH Q3a OH
    2438 CMe S Q1b a bond H a bond NH S NH Q3b OH
    2439 CMe S Q1b a bond H a bond NH S NH Q3c OH
    2440 CMe S Q1b a bond H a bond NH S a bond Q3a OH
    2441 CMe S Q1b a bond H a bond NH S a bond Q3b OH
    2442 CMe S Q1b a bond H a bond NH S a bond Q3c OH
    2443 CMe S Q1b a bond H a bond NH O NH Q3a OH
    2444 CMe S Q1b a bond H a bond NH O NH Q3b OH
    2445 CMe S Q1b a bond H a bond NH O NH Q3c OH
    2446 CMe S Q1b a bond H a bond NH O a bond Q3a OH
    2447 CMe S Q1b a bond H a bond NH O a bond Q3b OH
    2448 CMe S Q1b a bond H a bond NH O a bond Q3c OH
    2449 CMe S Q1c a bond Me a bond NH S NH Q3a OH
    2450 CMe S Q1c a bond Me a bond NH S NH Q3b OH
    2451 CMe S Q1c a bond Me a bond NH S NH Q3c OH
    2452 CMe S Q1c a bond Me a bond NH S a bond Q3a OH
    2453 CMe S Q1c a bond Me a bond NH S a bond Q3b OH
    2454 CMe S Q1c a bond Me a bond NH S a bond Q3c OH
    2455 CMe S Q1c a bond Me a bond NH O NH Q3a OH
    2456 CMe S Q1c a bond Me a bond NH O NH Q3b OH
    2457 CMe S Q1c a bond Me a bond NH O NH Q3c OH
    2458 CMe S Q1c a bond Me a bond NH O a bond Q3a OH
    2459 CMe S Q1c a bond Me a bond NH O a bond Q3b OH
    2460 CMe S Q1c a bond Me a bond NH O a bond Q3c OH
    2461 CMe S Q1c a bond H a bond NH S NH Q3a OH
    2462 CMe S Q1c a bond H a bond NH S NH Q3b OH
    2463 CMe S Q1c a bond H a bond NH S NH Q3c OH
    2464 CMe S Q1c a bond H a bond NH S a bond Q3a OH
    2465 CMe S Q1c a bond H a bond NH S a bond Q3b OH
    2466 CMe S Q1c a bond H a bond NH S a bond Q3c OH
    2467 CMe S Q1c a bond H a bond NH O NH Q3a OH
    2468 CMe S Q1c a bond H a bond NH O NH Q3b OH
    2469 CMe S Q1c a bond H a bond NH O NH Q3c OH
    2470 CMe S Q1c a bond H a bond NH O a bond Q3a OH
    2471 CMe S Q1c a bond H a bond NH O a bond Q3b OH
    2472 CMe S Q1c a bond H a bond NH O a bond Q3c OH
    2473 CMe S Q1d a bond Me a bond NH S NH Q3a OH
    2474 CMe S Q1d a bond Me a bond NH S NH Q3b OH
    2475 CMe S Q1d a bond Me a bond NH S NH Q3c OH
    2476 CMe S Q1d a bond Me a bond NH S a bond Q3a OH
    2477 CMe S Q1d a bond Me a bond NH S a bond Q3b OH
    2478 CMe S Q1d a bond Me a bond NH S a bond Q3c OH
    2479 CMe S Q1d a bond Me a bond NH O NH Q3a OH
    2480 CMe S Q1d a bond Me a bond NH O NH Q3b OH
    2481 CMe S Q1d a bond Me a bond NH O NH Q3c OH
    2482 CMe S Q1d a bond Me a bond NH O a bond Q3a OH
    2483 CMe S Q1d a bond Me a bond NH O a bond Q3b OH
    2484 CMe S Q1d a bond Me a bond NH O a bond Q3c OH
    2485 CMe S Q1d a bond H a bond NH S NH Q3a OH
    2486 CMe S Q1d a bond H a bond NH S NH Q3b OH
    2487 CMe S Q1d a bond H a bond NH S NH Q3c OH
    2488 CMe S Q1d a bond H a bond NH S a bond Q3a OH
    2489 CMe S Q1d a bond H a bond NH S a bond Q3b OH
    2490 CMe S Q1d a bond H a bond NH S a bond Q3c OH
    2491 CMe S Q1d a bond H a bond NH O NH Q3a OH
    2492 CMe S Q1d a bond H a bond NH O NH Q3b OH
    2493 CMe S Q1d a bond H a bond NH O NH Q3c OH
    2494 CMe S Q1d a bond H a bond NH O a bond Q3a OH
    2495 CMe S Q1d a bond H a bond NH O a bond Q3b OH
    2496 CMe S Q1d a bond H a bond NH O a bond Q3c OH
    2497 CMe S Q1e a bond Me a bond NH S NH Q3a OH
    2498 CMe S Q1e a bond Me a bond NH S NH Q3b OH
    2499 CMe S Q1e a bond Me a bond NH S NH Q3c OH
    2500 CMe S Q1e a bond Me a bond NH S a bond Q3a OH
    2501 CMe S Q1e a bond Me a bond NH S a bond Q3b OH
    2502 CMe S Q1e a bond Me a bond NH S a bond Q3c OH
    2503 CMe S Q1e a bond Me a bond NH O NH Q3a OH
    2504 CMe S Q1e a bond Me a bond NH O NH Q3b OH
    2505 CMe S Q1e a bond Me a bond NH O NH Q3c OH
    2506 CMe S Q1e a bond Me a bond NH O a bond Q3a OH
    2507 CMe S Q1e a bond Me a bond NH O a bond Q3b OH
    2508 CMe S Q1e a bond Me a bond NH O a bond Q3c OH
    2509 CMe S Q1e a bond H a bond NH S NH Q3a OH
    2510 CMe S Q1e a bond H a bond NH S NH Q3b OH
    2511 CMe S Q1e a bond H a bond NH S NH Q3c OH
    2512 CMe S Q1e a bond H a bond NH S a bond Q3a OH
    2513 CMe S Q1e a bond H a bond NH S a bond Q3b OH
    2514 CMe S Q1e a bond H a bond NH S a bond Q3c OH
    2515 CMe S Q1e a bond H a bond NH O NH Q3a OH
    2516 CMe S Q1e a bond H a bond NH O NH Q3b OH
    2517 CMe S Q1e a bond H a bond NH O NH Q3c OH
    2518 CMe S Q1e a bond H a bond NH O a bond Q3a OH
    2519 CMe S Q1e a bond H a bond NH O a bond Q3b OH
    2520 CMe S Q1e a bond H a bond NH O a bond Q3c OH
    2521 CMe S Q1f a bond Me a bond NH S NH Q3a OH
    2522 CMe S Q1f a bond Me a bond NH S NH Q3b OH
    2523 CMe S Q1f a bond Me a bond NH S NH Q3c OH
    2524 CMe S Q1f a bond Me a bond NH S a bond Q3a OH
    2525 CMe S Q1f a bond Me a bond NH S a bond Q3b OH
    2526 CMe S Q1f a bond Me a bond NH S a bond Q3c OH
    2527 CMe S Q1f a bond Me a bond NH O NH Q3a OH
    2528 CMe S Q1f a bond Me a bond NH O NH Q3b OH
    2529 CMe S Q1f a bond Me a bond NH O NH Q3c OH
    2530 CMe S Q1f a bond Me a bond NH O a bond Q3a OH
    2531 CMe S Q1f a bond Me a bond NH O a bond Q3b OH
    2532 CMe S Q1f a bond Me a bond NH O a bond Q3c OH
    2533 CMe S Q1f a bond H a bond NH S NH Q3a OH
    2534 CMe S Q1f a bond H a bond NH S NH Q3b OH
    2535 CMe S Q1f a bond H a bond NH S NH Q3c OH
    2536 CMe S Q1f a bond H a bond NH S a bond Q3a OH
    2537 CMe S Q1f a bond H a bond NH S a bond Q3b OH
    2538 CMe S Q1f a bond H a bond NH S a bond Q3c OH
    2539 CMe S Q1f a bond H a bond NH O NH Q3a OH
    2540 CMe S Q1f a bond H a bond NH O NH Q3b OH
    2541 CMe S Q1f a bond H a bond NH O NH Q3c OH
    2542 CMe S Q1f a bond H a bond NH O a bond Q3a OH
    2543 CMe S Q1f a bond H a bond NH O a bond Q3b OH
    2544 CMe S Q1f a bond H a bond NH O a bond Q3c OH
    2545 CMe S Q1g a bond Me a bond NH S NH Q3a OH
    2546 CMe S Q1g a bond Me a bond NH S NH Q3b OH
    2547 CMe S Q1g a bond Me a bond NH S NH Q3c OH
    2548 CMe S Q1g a bond Me a bond NH S a bond Q3a OH
    2549 CMe S Q1g a bond Me a bond NH S a bond Q3b OH
    2550 CMe S Q1g a bond Me a bond NH S a bond Q3c OH
    2551 CMe S Q1g a bond Me a bond NH O NH Q3a OH
    2552 CMe S Q1g a bond Me a bond NH O NH Q3b OH
    2553 CMe S Q1g a bond Me a bond NH O NH Q3c OH
    2554 CMe S Q1g a bond Me a bond NH O a bond Q3a OH
    2555 CMe S Q1g a bond Me a bond NH O a bond Q3b OH
    2556 CMe S Q1g a bond Me a bond NH O a bond Q3c OH
    2557 CMe S Q1g a bond H a bond NH S NH Q3a OH
    2558 CMe S Q1g a bond H a bond NH S NH Q3b OH
    2559 CMe S Q1g a bond H a bond NH S NH Q3c OH
    2560 CMe S Q1g a bond H a bond NH S a bond Q3a OH
    2561 CMe S Q1g a bond H a bond NH S a bond Q3b OH
    2562 CMe S Q1g a bond H a bond NH S a bond Q3c OH
    2563 CMe S Q1g a bond H a bond NH O NH Q3a OH
    2564 CMe S Q1g a bond H a bond NH O NH Q3b OH
    2565 CMe S Q1g a bond H a bond NH O NH Q3c OH
    2566 CMe S Q1g a bond H a bond NH O a bond Q3a OH
    2567 CMe S Q1g a bond H a bond NH O a bond Q3b OH
    2568 CMe S Q1g a bond H a bond NH O a bond Q3c OH
    2569 CMe S Q1h a bond Me a bond NH S NH Q3a OH
    2570 CMe S Q1h a bond Me a bond NH S NH Q3b OH
    2571 CMe S Q1h a bond Me a bond NH S NH Q3c OH
    2572 CMe S Q1h a bond Me a bond NH S a bond Q3a OH
    2573 CMe S Q1h a bond Me a bond NH S a bond Q3b OH
    2574 CMe S Q1h a bond Me a bond NH S a bond Q3c OH
    2575 CMe S Q1h a bond Me a bond NH O NH Q3a OH
    2576 CMe S Q1h a bond Me a bond NH O NH Q3b OH
    2577 CMe S Q1h a bond Me a bond NH O NH Q3c OH
    2578 CMe S Q1h a bond Me a bond NH O a bond Q3a OH
    2579 CMe S Q1h a bond Me a bond NH O a bond Q3b OH
    2580 CMe S Q1h a bond Me a bond NH O a bond Q3c OH
    2581 CMe S Q1h a bond H a bond NH S NH Q3a OH
    2582 CMe S Q1h a bond H a bond NH S NH Q3b OH
    2583 CMe S Q1h a bond H a bond NH S NH Q3c OH
    2584 CMe S Q1h a bond H a bond NH S a bond Q3a OH
    2585 CMe S Q1h a bond H a bond NH S a bond Q3b OH
    2586 CMe S Q1h a bond H a bond NH S a bond Q3c OH
    2587 CMe S Q1h a bond H a bond NH O NH Q3a OH
    2588 CMe S Q1h a bond H a bond NH O NH Q3b OH
    2589 CMe S Q1h a bond H a bond NH O NH Q3c OH
    2590 CMe S Q1h a bond H a bond NH O a bond Q3a OH
    2591 CMe S Q1h a bond H a bond NH O a bond Q3b OH
    2592 CMe S Q1h a bond H a bond NH O a bond Q3c OH
    2593 CMe S Q1i a bond Me a bond NH S NH Q3a OH
    2594 CMe S Q1i a bond Me a bond NH S NH Q3b OH
    2595 CMe S Q1i a bond Me a bond NH S NH Q3c OH
    2596 CMe S Q1i a bond Me a bond NH S a bond Q3a OH
    2597 CMe S Q1i a bond Me a bond NH S a bond Q3b OH
    2598 CMe S Q1i a bond Me a bond NH S a bond Q3c OH
    2599 CMe S Q1i a bond Me a bond NH O NH Q3a OH
    2600 CMe S Q1i a bond Me a bond NH O NH Q3b OH
    2601 CMe S Q1i a bond Me a bond NH O NH Q3c OH
    2602 CMe S Q1i a bond Me a bond NH O a bond Q3a OH
    2603 CMe S Q1i a bond Me a bond NH O a bond Q3b OH
    2604 CMe S Q1i a bond Me a bond NH O a bond Q3c OH
    2605 CMe S Q1i a bond H a bond NH S NH Q3a OH
    2606 CMe S Q1i a bond H a bond NH S NH Q3b OH
    2607 CMe S Q1i a bond H a bond NH S NH Q3c OH
    2608 CMe S Q1i a bond H a bond NH S a bond Q3a OH
    2609 CMe S Q1i a bond H a bond NH S a bond Q3b OH
    2610 CMe S Q1i a bond H a bond NH S a bond Q3c OH
    2611 CMe S Q1i a bond H a bond NH O NH Q3a OH
    2612 CMe S Q1i a bond H a bond NH O NH Q3b OH
    2613 CMe S Q1i a bond H a bond NH O NH Q3c OH
    2614 CMe S Q1i a bond H a bond NH O a bond Q3a OH
    2615 CMe S Q1i a bond H a bond NH O a bond Q3b OH
    2616 CMe S Q1i a bond H a bond NH O a bond Q3c OH
    2617 CMe S Q1j a bond Me a bond NH S NH Q3a OH
    2618 CMe S Q1j a bond Me a bond NH S NH Q3b OH
    2619 CMe S Q1j a bond Me a bond NH S NH Q3c OH
    2620 CMe S Q1j a bond Me a bond NH S a bond Q3a OH
    2621 CMe S Q1j a bond Me a bond NH S a bond Q3b OH
    2622 CMe S Q1j a bond Me a bond NH S a bond Q3c OH
    2623 CMe S Q1j a bond Me a bond NH O NH Q3a OH
    2624 CMe S Q1j a bond Me a bond NH O NH Q3b OH
    2625 CMe S Q1j a bond Me a bond NH O NH Q3c OH
    2626 CMe S Q1j a bond Me a bond NH O a bond Q3a OH
    2627 CMe S Q1j a bond Me a bond NH O a bond Q3b OH
    2628 CMe S Q1j a bond Me a bond NH O a bond Q3c OH
    2629 CMe S Q1j a bond H a bond NH S NH Q3a OH
    2630 CMe S Q1j a bond H a bond NH S NH Q3b OH
    2631 CMe S Q1j a bond H a bond NH S NH Q3c OH
    2632 CMe S Q1j a bond H a bond NH S a bond Q3a OH
    2633 CMe S Q1j a bond H a bond NH S a bond Q3b OH
    2634 CMe S Q1j a bond H a bond NH S a bond Q3c OH
    2635 CMe S Q1j a bond H a bond NH O NH Q3a OH
    2636 CMe S Q1j a bond H a bond NH O NH Q3b OH
    2637 CMe S Q1j a bond H a bond NH O NH Q3c OH
    2638 CMe S Q1j a bond H a bond NH O a bond Q3a OH
    2639 CMe S Q1j a bond H a bond NH O a bond Q3b OH
    2640 CMe S Q1j a bond H a bond NH O a bond Q3c OH
    2641 CMe O Q1a a bond Me a bond NH S NH Q3a OH
    2642 CMe O Q1a a bond Me a bond NH S NH Q3b OH
    2643 CMe O Q1a a bond Me a bond NH S NH Q3c OH
    2644 CMe O Q1a a bond Me a bond NH S a bond Q3a OH
    2645 CMe O Q1a a bond Me a bond NH S a bond Q3b OH
    2646 CMe O Q1a a bond Me a bond NH S a bond Q3c OH
    2647 CMe O Q1a a bond Me a bond NH O NH Q3a OH
    2648 CMe O Q1a a bond Me a bond NH O NH Q3b OH
    2649 CMe O Q1a a bond Me a bond NH O NH Q3c OH
    2650 CMe O Q1a a bond Me a bond NH O a bond Q3a OH
    2651 CMe O Q1a a bond Me a bond NH O a bond Q3b OH
    2652 CMe O Q1a a bond Me a bond NH O a bond Q3c OH
    2653 CMe O Q1a a bond H a bond NH S NH Q3a OH
    2654 CMe O Q1a a bond H a bond NH S NH Q3b OH
    2655 CMe O Q1a a bond H a bond NH S NH Q3c OH
    2656 CMe O Q1a a bond H a bond NH S a bond Q3a OH
    2657 CMe O Q1a a bond H a bond NH S a bond Q3b OH
    2658 CMe O Q1a a bond H a bond NH S a bond Q3c OH
    2659 CMe O Q1a a bond H a bond NH O NH Q3a OH
    2660 CMe O Q1a a bond H a bond NH O NH Q3b OH
    2661 CMe O Q1a a bond H a bond NH O NH Q3c OH
    2662 CMe O Q1a a bond H a bond NH O a bond Q3a OH
    2663 CMe O Q1a a bond H a bond NH O a bond Q3b OH
    2664 CMe O Q1a a bond H a bond NH O a bond Q3c OH
    2665 CMe O Q1b a bond Me a bond NH S NH Q3a OH
    2666 CMe O Q1b a bond Me a bond NH S NH Q3b OH
    2667 CMe O Q1b a bond Me a bond NH S NH Q3c OH
    2668 CMe O Q1b a bond Me a bond NH S a bond Q3a OH
    2669 CMe O Q1b a bond Me a bond NH S a bond Q3b OH
    2670 CMe O Q1b a bond Me a bond NH S a bond Q3c OH
    2671 CMe O Q1b a bond Me a bond NH O NH Q3a OH
    2672 CMe O Q1b a bond Me a bond NH O NH Q3b OH
    2673 CMe O Q1b a bond Me a bond NH O NH Q3c OH
    2674 CMe O Q1b a bond Me a bond NH O a bond Q3a OH
    2675 CMe O Q1b a bond Me a bond NH O a bond Q3b OH
    2676 CMe O Q1b a bond Me a bond NH O a bond Q3c OH
    2677 CMe O Q1b a bond H a bond NH S NH Q3a OH
    2678 CMe O Q1b a bond H a bond NH S NH Q3b OH
    2679 CMe O Q1b a bond H a bond NH S NH Q3c OH
    2680 CMe O Q1b a bond H a bond NH S a bond Q3a OH
    2681 CMe O Q1b a bond H a bond NH S a bond Q3b OH
    2682 CMe O Q1b a bond H a bond NH S a bond Q3c OH
    2683 CMe O Q1b a bond H a bond NH O NH Q3a OH
    2684 CMe O Q1b a bond H a bond NH O NH Q3b OH
    2685 CMe O Q1b a bond H a bond NH O NH Q3c OH
    2686 CMe O Q1b a bond H a bond NH O a bond Q3a OH
    2687 CMe O Q1b a bond H a bond NH O a bond Q3b OH
    2688 CMe O Q1b a bond H a bond NH O a bond Q3c OH
    2689 CMe O Q1c a bond Me a bond NH S NH Q3a OH
    2690 CMe O Q1c a bond Me a bond NH S NH Q3b OH
    2691 CMe O Q1c a bond Me a bond NH S NH Q3c OH
    2692 CMe O Q1c a bond Me a bond NH S a bond Q3a OH
    2693 CMe O Q1c a bond Me a bond NH S a bond Q3b OH
    2694 CMe O Q1c a bond Me a bond NH S a bond Q3c OH
    2695 CMe O Q1c a bond Me a bond NH O NH Q3a OH
    2696 CMe O Q1c a bond Me a bond NH O NH Q3b OH
    2697 CMe O Q1c a bond Me a bond NH O NH Q3c OH
    2698 CMe O Q1c a bond Me a bond NH O a bond Q3a OH
    2699 CMe O Q1c a bond Me a bond NH O a bond Q3b OH
    2700 CMe O Q1c a bond Me a bond NH O a bond Q3c OH
    2701 CMe O Q1c a bond H a bond NH S NH Q3a OH
    2702 CMe O Q1c a bond H a bond NH S NH Q3b OH
    2703 CMe O Q1c a bond H a bond NH S NH Q3c OH
    2704 CMe O Q1c a bond H a bond NH S a bond Q3a OH
    2705 CMe O Q1c a bond H a bond NH S a bond Q3b OH
    2706 CMe O Q1c a bond H a bond NH S a bond Q3c OH
    2707 CMe O Q1c a bond H a bond NH O NH Q3a OH
    2708 CMe O Q1c a bond H a bond NH O NH Q3b OH
    2709 CMe O Q1c a bond H a bond NH O NH Q3c OH
    2710 CMe O Q1c a bond H a bond NH O a bond Q3a OH
    2711 CMe O Q1c a bond H a bond NH O a bond Q3b OH
    2712 CMe O Q1c a bond H a bond NH O a bond Q3c OH
    2713 CMe O Q1d a bond Me a bond NH S NH Q3a OH
    2714 CMe O Q1d a bond Me a bond NH S NH Q3b OH
    2715 CMe O Q1d a bond Me a bond NH S NH Q3c OH
    2716 CMe O Q1d a bond Me a bond NH S a bond Q3a OH
    2717 CMe O Q1d a bond Me a bond NH S a bond Q3b OH
    2718 CMe O Q1d a bond Me a bond NH S a bond Q3c OH
    2719 CMe O Q1d a bond Me a bond NH O NH Q3a OH
    2720 CMe O Q1d a bond Me a bond NH O NH Q3b OH
    2721 CMe O Q1d a bond Me a bond NH O NH Q3c OH
    2722 CMe O Q1d a bond Me a bond NH O a bond Q3a OH
    2723 CMe O Q1d a bond Me a bond NH O a bond Q3b OH
    2724 CMe O Q1d a bond Me a bond NH O a bond Q3c OH
    2725 CMe O Q1d a bond H a bond NH S NH Q3a OH
    2726 CMe O Q1d a bond H a bond NH S NH Q3b OH
    2727 CMe O Q1d a bond H a bond NH S NH Q3c OH
    2728 CMe O Q1d a bond H a bond NH S a bond Q3a OH
    2729 CMe O Q1d a bond H a bond NH S a bond Q3b OH
    2730 CMe O Q1d a bond H a bond NH S a bond Q3c OH
    2731 CMe O Q1d a bond H a bond NH O NH Q3a OH
    2732 CMe O Q1d a bond H a bond NH O NH Q3b OH
    2733 CMe O Q1d a bond H a bond NH O NH Q3c OH
    2734 CMe O Q1d a bond H a bond NH O a bond Q3a OH
    2735 CMe O Q1d a bond H a bond NH O a bond Q3b OH
    2736 CMe O Q1d a bond H a bond NH O a bond Q3c OH
    2737 CMe O Q1e a bond Me a bond NH S NH Q3a OH
    2738 CMe O Q1e a bond Me a bond NH S NH Q3b OH
    2739 CMe O Q1e a bond Me a bond NH S NH Q3c OH
    2740 CMe O Q1e a bond Me a bond NH S a bond Q3a OH
    2741 CMe O Q1e a bond Me a bond NH S a bond Q3b OH
    2742 CMe O Q1e a bond Me a bond NH S a bond Q3c OH
    2743 CMe O Q1e a bond Me a bond NH O NH Q3a OH
    2744 CMe O Q1e a bond Me a bond NH O NH Q3b OH
    2745 CMe O Q1e a bond Me a bond NH O NH Q3c OH
    2746 CMe O Q1e a bond Me a bond NH O a bond Q3a OH
    2747 CMe O Q1e a bond Me a bond NH O a bond Q3b OH
    2748 CMe O Q1e a bond Me a bond NH O a bond Q3c OH
    2749 CMe O Q1e a bond H a bond NH S NH Q3a OH
    2750 CMe O Q1e a bond H a bond NH S NH Q3b OH
    2751 CMe O Q1e a bond H a bond NH S NH Q3c OH
    2752 CMe O Q1e a bond H a bond NH S a bond Q3a OH
    2753 CMe O Q1e a bond H a bond NH S a bond Q3b OH
    2754 CMe O Q1e a bond H a bond NH S a bond Q3c OH
    2755 CMe O Q1e a bond H a bond NH O NH Q3a OH
    2756 CMe O Q1e a bond H a bond NH O NH Q3b OH
    2757 CMe O Q1e a bond H a bond NH O NH Q3c OH
    2758 CMe O Q1e a bond H a bond NH O a bond Q3a OH
    2759 CMe O Q1e a bond H a bond NH O a bond Q3b OH
    2760 CMe O Q1e a bond H a bond NH O a bond Q3c OH
    2761 CMe O Q1f a bond Me a bond NH S NH Q3a OH
    2762 CMe O Q1f a bond Me a bond NH S NH Q3b OH
    2763 CMe O Q1f a bond Me a bond NH S NH Q3c OH
    2764 CMe O Q1f a bond Me a bond NH S a bond Q3a OH
    2765 CMe O Q1f a bond Me a bond NH S a bond Q3b OH
    2766 CMe O Q1f a bond Me a bond NH S a bond Q3c OH
    2767 CMe O Q1f a bond Me a bond NH O NH Q3a OH
    2768 CMe O Q1f a bond Me a bond NH O NH Q3b OH
    2769 CMe O Q1f a bond Me a bond NH O NH Q3c OH
    2770 CMe O Q1f a bond Me a bond NH O a bond Q3a OH
    2771 CMe O Q1f a bond Me a bond NH O a bond Q3b OH
    2772 CMe O Q1f a bond Me a bond NH O a bond Q3c OH
    2773 CMe O Q1f a bond H a bond NH S NH Q3a OH
    2774 CMe O Q1f a bond H a bond NH S NH Q3b OH
    2775 CMe O Q1f a bond H a bond NH S NH Q3c OH
    2776 CMe O Q1f a bond H a bond NH S a bond Q3a OH
    2777 CMe O Q1f a bond H a bond NH S a bond Q3b OH
    2778 CMe O Q1f a bond H a bond NH S a bond Q3c OH
    2779 CMe O Q1f a bond H a bond NH O NH Q3a OH
    2780 CMe O Q1f a bond H a bond NH O NH Q3b OH
    2781 CMe O Q1f a bond H a bond NH O NH Q3c OH
    2782 CMe O Q1f a bond H a bond NH O a bond Q3a OH
    2783 CMe O Q1f a bond H a bond NH O a bond Q3b OH
    2784 CMe O Q1f a bond H a bond NH O a bond Q3c OH
    2785 CMe O Q1g a bond Me a bond NH S NH Q3a OH
    2786 CMe O Q1g a bond Me a bond NH S NH Q3b OH
    2787 CMe O Q1g a bond Me a bond NH S NH Q3c OH
    2788 CMe O Q1g a bond Me a bond NH S a bond Q3a OH
    2789 CMe O Q1g a bond Me a bond NH S a bond Q3b OH
    2790 CMe O Q1g a bond Me a bond NH S a bond Q3c OH
    2791 CMe O Q1g a bond Me a bond NH O NH Q3a OH
    2792 CMe O Q1g a bond Me a bond NH O NH Q3b OH
    2793 CMe O Q1g a bond Me a bond NH O NH Q3c OH
    2794 CMe O Q1g a bond Me a bond NH O a bond Q3a OH
    2795 CMe O Q1g a bond Me a bond NH O a bond Q3b OH
    2796 CMe O Q1g a bond Me a bond NH O a bond Q3c OH
    2797 CMe O Q1g a bond H a bond NH S NH Q3a OH
    2798 CMe O Q1g a bond H a bond NH S NH Q3b OH
    2799 CMe O Q1g a bond H a bond NH S NH Q3c OH
    2800 CMe O Q1g a bond H a bond NH S a bond Q3a OH
    2801 CMe O Q1g a bond H a bond NH S a bond Q3b OH
    2802 CMe O Q1g a bond H a bond NH S a bond Q3c OH
    2803 CMe O Q1g a bond H a bond NH O NH Q3a OH
    2804 CMe O Q1g a bond H a bond NH O NH Q3b OH
    2805 CMe O Q1g a bond H a bond NH O NH Q3c OH
    2806 CMe O Q1g a bond H a bond NH O a bond Q3a OH
    2807 CMe O Q1g a bond H a bond NH O a bond Q3b OH
    2808 CMe O Q1g a bond H a bond NH O a bond Q3c OH
    2809 CMe O Q1h a bond Me a bond NH S NH Q3a OH
    2810 CMe O Q1h a bond Me a bond NH S NH Q3b OH
    2811 CMe O Q1h a bond Me a bond NH S NH Q3c OH
    2812 CMe O Q1h a bond Me a bond NH S a bond Q3a OH
    2813 CMe O Q1h a bond Me a bond NH S a bond Q3b OH
    2814 CMe O Q1h a bond Me a bond NH S a bond Q3c OH
    2815 CMe O Q1h a bond Me a bond NH O NH Q3a OH
    2816 CMe O Q1h a bond Me a bond NH O NH Q3b OH
    2817 CMe O Q1h a bond Me a bond NH O NH Q3c OH
    2818 CMe O Q1h a bond Me a bond NH O a bond Q3a OH
    2819 CMe O Q1h a bond Me a bond NH O a bond Q3b OH
    2820 CMe O Q1h a bond Me a bond NH O a bond Q3c OH
    2821 CMe O Q1h a bond H a bond NH S NH Q3a OH
    2822 CMe O Q1h a bond H a bond NH S NH Q3b OH
    2823 CMe O Q1h a bond H a bond NH S NH Q3c OH
    2824 CMe O Q1h a bond H a bond NH S a bond Q3a OH
    2825 CMe O Q1h a bond H a bond NH S a bond Q3b OH
    2826 CMe O Q1h a bond H a bond NH S a bond Q3c OH
    2827 CMe O Q1h a bond H a bond NH O NH Q3a OH
    2828 CMe O Q1h a bond H a bond NH O NH Q3b OH
    2829 CMe O Q1h a bond H a bond NH O NH Q3c OH
    2830 CMe O Q1h a bond H a bond NH O a bond Q3a OH
    2831 CMe O Q1h a bond H a bond NH O a bond Q3b OH
    2832 CMe O Q1h a bond H a bond NH O a bond Q3c OH
    2833 CMe O Q1i a bond Me a bond NH S NH Q3a OH
    2834 CMe O Q1i a bond Me a bond NH S NH Q3b OH
    2835 CMe O Q1i a bond Me a bond NH S NH Q3c OH
    2836 CMe O Q1i a bond Me a bond NH S a bond Q3a OH
    2837 CMe O Q1i a bond Me a bond NH S a bond Q3b OH
    2838 CMe O Q1i a bond Me a bond NH S a bond Q3c OH
    2839 CMe O Q1i a bond Me a bond NH O NH Q3a OH
    2840 CMe O Q1i a bond Me a bond NH O NH Q3b OH
    2841 CMe O Q1i a bond Me a bond NH O NH Q3c OH
    2842 CMe O Q1i a bond Me a bond NH O a bond Q3a OH
    2843 CMe O Q1i a bond Me a bond NH O a bond Q3b OH
    2844 CMe O Q1i a bond Me a bond NH O a bond Q3c OH
    2845 CMe O Q1i a bond H a bond NH S NH Q3a OH
    2846 CMe O Q1i a bond H a bond NH S NH Q3b OH
    2847 CMe O Q1i a bond H a bond NH S NH Q3c OH
    2848 CMe O Q1i a bond H a bond NH S a bond Q3a OH
    2849 CMe O Q1i a bond H a bond NH S a bond Q3b OH
    2850 CMe O Q1i a bond H a bond NH S a bond Q3c OH
    2851 CMe O Q1i a bond H a bond NH O NH Q3a OH
    2852 CMe O Q1i a bond H a bond NH O NH Q3b OH
    2853 CMe O Q1i a bond H a bond NH O NH Q3c OH
    2854 CMe O Q1i a bond H a bond NH O a bond Q3a OH
    2855 CMe O Q1i a bond H a bond NH O a bond Q3b OH
    2856 CMe O Q1i a bond H a bond NH O a bond Q3c OH
    2857 CMe O Q1j a bond Me a bond NH S NH Q3a OH
    2858 CMe O Q1j a bond Me a bond NH S NH Q3b OH
    2859 CMe O Q1j a bond Me a bond NH S NH Q3c OH
    2860 CMe O Q1j a bond Me a bond NH S a bond Q3a OH
    2861 CMe O Q1j a bond Me a bond NH S a bond Q3b OH
    2862 CMe O Q1j a bond Me a bond NH S a bond Q3c OH
    2863 CMe O Q1j a bond Me a bond NH O NH Q3a OH
    2864 CMe O Q1j a bond Me a bond NH O NH Q3b OH
    2865 CMe O Q1j a bond Me a bond NH O NH Q3c OH
    2866 CMe O Q1j a bond Me a bond NH O a bond Q3a OH
    2867 CMe O Q1j a bond Me a bond NH O a bond Q3b OH
    2868 CMe O Q1j a bond Me a bond NH O a bond Q3c OH
    2869 CMe O Q1j a bond H a bond NH S NH Q3a OH
    2870 CMe O Q1j a bond H a bond NH S NH Q3b OH
    2871 CMe O Q1j a bond H a bond NH S NH Q3c OH
    2872 CMe O Q1j a bond H a bond NH S a bond Q3a OH
    2873 CMe O Q1j a bond H a bond NH S a bond Q3b OH
    2874 CMe O Q1j a bond H a bond NH S a bond Q3c OH
    2875 CMe O Q1j a bond H a bond NH O NH Q3a OH
    2876 CMe O Q1j a bond H a bond NH O NH Q3b OH
    2877 CMe O Q1j a bond H a bond NH O NH Q3c OH
    2878 CMe O Q1j a bond H a bond NH O a bond Q3a OH
    2879 CMe O Q1j a bond H a bond NH O a bond Q3b OH
    2880 CMe O Q1j a bond H a bond NH O a bond Q3c OH
    2881 N NMe Q1k a bond Me a bond NH O a bond Q3a OH
    2882 N NMe Q1k a bond Me a bond NH O a bond Q3d OH
    2883 N NMe Q1k a bond Me a bond NH O a bond Q3e OH
    2884 N NMe Q1k a bond Me a bond NH O a bond Q3f OH
    2885 N NMe Q1k a bond Me a bond NH O NH Q3a OH
    2886 N NMe Q1k a bond Me a bond NH O NH Q3d OH
    2887 N NMe Q1k a bond Me a bond NH O NH Q3e OH
    2888 N NMe Q1k a bond Me a bond NH O NH Q3f OH
    2889 N NMe Q1k a bond Me a bond NH S a bond Q3a OH
    2890 N NMe Q1k a bond Me a bond NH S a bond Q3d OH
    2891 N NMe Q1k a bond Me a bond NH S a bond Q3e OH
    2892 N NMe Q1k a bond Me a bond NH S a bond Q3f OH
    2893 N NMe Q1k a bond Me a bond NH S NH Q3a OH
    2894 N NMe Q1k a bond Me a bond NH S NH Q3d OH
    2895 N NMe Q1k a bond Me a bond NH S NH Q3e OH
    2896 N NMe Q1k a bond Me a bond NH S NH Q3f OH
    2897 N NMe Q1l a bond Me a bond NH O a bond Q3a OH
    2898 N NMe Q1l a bond Me a bond NH O a bond Q3d OH
    2899 N NMe Q1l a bond Me a bond NH O a bond Q3e OH
    2900 N NMe Q1l a bond Me a bond NH O a bond Q3f OH
    2901 N NMe Q1l a bond Me a bond NH O NH Q3a OH
    2902 N NMe Q1l a bond Me a bond NH O NH Q3d OH
    2903 N NMe Q1l a bond Me a bond NH O NH Q3e OH
    2904 N NMe Q1l a bond Me a bond NH O NH Q3f OH
    2905 N NMe Q1l a bond Me a bond NH S a bond Q3a OH
    2906 N NMe Q1l a bond Me a bond NH S a bond Q3d OH
    2907 N NMe Q1l a bond Me a bond NH S a bond Q3e OH
    2908 N NMe Q1l a bond Me a bond NH S a bond Q3f OH
    2909 N NMe Q1l a bond Me a bond NH S NH Q3a OH
    2910 N NMe Q1l a bond Me a bond NH S NH Q3d OH
    2911 N NMe Q1l a bond Me a bond NH S NH Q3e OH
    2912 N NMe Q1l a bond Me a bond NH S NH Q3f OH
    2913 N NMe Q1m a bond Me a bond NH O a bond Q3a OH
    2914 N NMe Q1m a bond Me a bond NH O a bond Q3d OH
    2915 N NMe Q1m a bond Me a bond NH O a bond Q3e OH
    2916 N NMe Q1m a bond Me a bond NH O a bond Q3f OH
    2917 N NMe Q1m a bond Me a bond NH O NH Q3a OH
    2918 N NMe Q1m a bond Me a bond NH O NH Q3d OH
    2919 N NMe Q1m a bond Me a bond NH O NH Q3e OH
    2920 N NMe Q1m a bond Me a bond NH O NH Q3f OH
    2921 N NMe Q1m a bond Me a bond NH S a bond Q3a OH
    2922 N NMe Q1m a bond Me a bond NH S a bond Q3d OH
    2923 N NMe Q1m a bond Me a bond NH S a bond Q3e OH
    2924 N NMe Q1m a bond Me a bond NH S a bond Q3f OH
    2925 N NMe Q1m a bond Me a bond NH S NH Q3a OH
    2926 N NMe Q1m a bond Me a bond NH S NH Q3d OH
    2927 N NMe Q1m a bond Me a bond NH S NH Q3e OH
    2928 N NMe Q1m a bond Me a bond NH S NH Q3f OH
    2929 N NMe Q1n a bond Me a bond NH O a bond Q3a OH
    2930 N NMe Q1n a bond Me a bond NH O a bond Q3d OH
    2931 N NMe Q1n a bond Me a bond NH O a bond Q3e OH
    2932 N NMe Q1n a bond Me a bond NH O a bond Q3f OH
    2933 N NMe Q1n a bond Me a bond NH O NH Q3a OH
    2934 N NMe Q1n a bond Me a bond NH O NH Q3d OH
    2935 N NMe Q1n a bond Me a bond NH O NH Q3e OH
    2936 N NMe Q1n a bond Me a bond NH O NH Q3f OH
    2937 N NMe Q1n a bond Me a bond NH S a bond Q3a OH
    2938 N NMe Q1n a bond Me a bond NH S a bond Q3d OH
    2939 N NMe Q1n a bond Me a bond NH S a bond Q3e OH
    2940 N NMe Q1n a bond Me a bond NH S a bond Q3f OH
    2941 N NMe Q1n a bond Me a bond NH S NH Q3a OH
    2942 N NMe Q1n a bond Me a bond NH S NH Q3d OH
    2943 N NMe Q1n a bond Me a bond NH S NH Q3e OH
    2944 N NMe Q1n a bond Me a bond NH S NH Q3f OH
    2945 N NEt Q1k a bond Me a bond NH O a bond Q3a OH
    2946 N NEt Q1k a bond Me a bond NH O a bond Q3d OH
    2947 N NEt Q1k a bond Me a bond NH O a bond Q3e OH
    2948 N NEt Q1k a bond Me a bond NH O a bond Q3f OH
    2949 N NEt Q1k a bond Me a bond NH O NH Q3a OH
    2950 N NEt Q1k a bond Me a bond NH O NH Q3d OH
    2951 N NEt Q1k a bond Me a bond NH O NH Q3e OH
    2952 N NEt Q1k a bond Me a bond NH O NH Q3f OH
    2953 N NEt Q1k a bond Me a bond NH S a bond Q3a OH
    2954 N NEt Q1k a bond Me a bond NH S a bond Q3d OH
    2955 N NEt Q1k a bond Me a bond NH S a bond Q3e OH
    2956 N NEt Q1k a bond Me a bond NH S a bond Q3f OH
    2957 N NEt Q1k a bond Me a bond NH S NH Q3a OH
    2958 N NEt Q1k a bond Me a bond NH S NH Q3d OH
    2959 N NEt Q1k a bond Me a bond NH S NH Q3e OH
    2960 N NEt Q1k a bond Me a bond NH S NH Q3f OH
    2961 N NEt Q1l a bond Me a bond NH O a bond Q3a OH
    2962 N NEt Q1l a bond Me a bond NH O a bond Q3d OH
    2963 N NEt Q1l a bond Me a bond NH O a bond Q3e OH
    2964 N NEt Q1l a bond Me a bond NH O a bond Q3f OH
    2965 N NEt Q1l a bond Me a bond NH O NH Q3a OH
    2966 N NEt Q1l a bond Me a bond NH O NH Q3d OH
    2967 N NEt Q1l a bond Me a bond NH O NH Q3e OH
    2968 N NEt Q1l a bond Me a bond NH O NH Q3f OH
    2969 N NEt Q1l a bond Me a bond NH S a bond Q3a OH
    2970 N NEt Q1l a bond Me a bond NH S a bond Q3d OH
    2971 N NEt Q1l a bond Me a bond NH S a bond Q3e OH
    2972 N NEt Q1l a bond Me a bond NH S a bond Q3f OH
    2973 N NEt Q1l a bond Me a bond NH S NH Q3a OH
    2974 N NEt Q1l a bond Me a bond NH S NH Q3d OH
    2975 N NEt Q1l a bond Me a bond NH S NH Q3e OH
    2976 N NEt Q1l a bond Me a bond NH S NH Q3f OH
    2977 N NEt Q1m a bond Me a bond NH O a bond Q3a OH
    2978 N NEt Q1m a bond Me a bond NH O a bond Q3d OH
    2979 N NEt Q1m a bond Me a bond NH O a bond Q3e OH
    2980 N NEt Q1m a bond Me a bond NH O a bond Q3f OH
    2981 N NEt Q1m a bond Me a bond NH O NH Q3a OH
    2982 N NEt Q1m a bond Me a bond NH O NH Q3d OH
    2983 N NEt Q1m a bond Me a bond NH O NH Q3e OH
    2984 N NEt Q1m a bond Me a bond NH O NH Q3f OH
    2985 N NEt Q1m a bond Me a bond NH S a bond Q3a OH
    2986 N NEt Q1m a bond Me a bond NH S a bond Q3d OH
    2987 N NEt Q1m a bond Me a bond NH S a bond Q3e OH
    2988 N NEt Q1m a bond Me a bond NH S a bond Q3f OH
    2989 N NEt Q1m a bond Me a bond NH S NH Q3a OH
    2990 N NEt Q1m a bond Me a bond NH S NH Q3d OH
    2991 N NEt Q1m a bond Me a bond NH S NH Q3e OH
    2992 N NEt Q1m a bond Me a bond NH S NH Q3f OH
    2993 N NEt Q1n a bond Me a bond NH O a bond Q3a OH
    2994 N NEt Q1n a bond Me a bond NH O a bond Q3d OH
    2995 N NEt Q1n a bond Me a bond NH O a bond Q3e OH
    2996 N NEt Q1n a bond Me a bond NH O a bond Q3f OH
    2997 N NEt Q1n a bond Me a bond NH O NH Q3a OH
    2998 N NEt Q1n a bond Me a bond NH O NH Q3d OH
    2999 N NEt Q1n a bond Me a bond NH O NH Q3e OH
    3000 N NEt Q1n a bond Me a bond NH O NH Q3f OH
    3001 N NEt Q1n a bond Me a bond NH S a bond Q3a OH
    3002 N NEt Q1n a bond Me a bond NH S a bond Q3d OH
    3003 N NEt Q1n a bond Me a bond NH S a bond Q3e OH
    3004 N NEt Q1n a bond Me a bond NH S a bond Q3f OH
    3005 N NEt Q1n a bond Me a bond NH S NH Q3a OH
    3006 N NEt Q1n a bond Me a bond NH S NH Q3d OH
    3007 N NEt Q1n a bond Me a bond NH S NH Q3e OH
    3008 N NEt Q1n a bond Me a bond NH S NH Q3f OH
    3009 N S Q1k a bond Me a bond NH O a bond Q3a OH
    3010 N S Q1k a bond Me a bond NH O a bond Q3d OH
    3011 N S Q1k a bond Me a bond NH O a bond Q3e OH
    3012 N S Q1k a bond Me a bond NH O a bond Q3f OH
    3013 N S Q1k a bond Me a bond NH O NH Q3a OH
    3014 N S Q1k a bond Me a bond NH O NH Q3d OH
    3015 N S Q1k a bond Me a bond NH O NH Q3e OH
    3016 N S Q1k a bond Me a bond NH O NH Q3f OH
    3017 N S Q1k a bond Me a bond NH S a bond Q3a OH
    3018 N S Q1k a bond Me a bond NH S a bond Q3d OH
    3019 N S Q1k a bond Me a bond NH S a bond Q3e OH
    3020 N S Q1k a bond Me a bond NH S a bond Q3f OH
    3021 N S Q1k a bond Me a bond NH S NH Q3a OH
    3022 N S Q1k a bond Me a bond NH S NH Q3d OH
    3023 N S Q1k a bond Me a bond NH S NH Q3e OH
    3024 N S Q1k a bond Me a bond NH S NH Q3f OH
    3025 N S Q1l a bond Me a bond NH O a bond Q3a OH
    3026 N S Q1l a bond Me a bond NH O a bond Q3d OH
    3027 N S Q1l a bond Me a bond NH O a bond Q3e OH
    3028 N S Q1l a bond Me a bond NH O a bond Q3f OH
    3029 N S Q1l a bond Me a bond NH O NH Q3a OH
    3030 N S Q1l a bond Me a bond NH O NH Q3d OH
    3031 N S Q1l a bond Me a bond NH O NH Q3e OH
    3032 N S Q1l a bond Me a bond NH O NH Q3f OH
    3033 N S Q1l a bond Me a bond NH S a bond Q3a OH
    3034 N S Q1l a bond Me a bond NH S a bond Q3d OH
    3035 N S Q1l a bond Me a bond NH S a bond Q3e OH
    3036 N S Q1l a bond Me a bond NH S a bond Q3f OH
    3037 N S Q1l a bond Me a bond NH S NH Q3a OH
    3038 N S Q1l a bond Me a bond NH S NH Q3d OH
    3039 N S Q1l a bond Me a bond NH S NH Q3e OH
    3040 N S Q1l a bond Me a bond NH S NH Q3f OH
    3041 N S Q1m a bond Me a bond NH O a bond Q3a OH
    3042 N S Q1m a bond Me a bond NH O a bond Q3d OH
    3043 N S Q1m a bond Me a bond NH O a bond Q3e OH
    3044 N S Q1m a bond Me a bond NH O a bond Q3f OH
    3045 N S Q1m a bond Me a bond NH O NH Q3a OH
    3046 N S Q1m a bond Me a bond NH O NH Q3d OH
    3047 N S Q1m a bond Me a bond NH O NH Q3e OH
    3048 N S Q1m a bond Me a bond NH O NH Q3f OH
    3049 N S Q1m a bond Me a bond NH S a bond Q3a OH
    3050 N S Q1m a bond Me a bond NH S a bond Q3d OH
    3051 N S Q1m a bond Me a bond NH S a bond Q3e OH
    3052 N S Q1m a bond Me a bond NH S a bond Q3f OH
    3053 N S Q1m a bond Me a bond NH S NH Q3a OH
    3054 N S Q1m a bond Me a bond NH S NH Q3d OH
    3055 N S Q1m a bond Me a bond NH S NH Q3e OH
    3056 N S Q1m a bond Me a bond NH S NH Q3f OH
    3057 N S Q1n a bond Me a bond NH O a bond Q3a OH
    3058 N S Q1n a bond Me a bond NH O a bond Q3d OH
    3059 N S Q1n a bond Me a bond NH O a bond Q3e OH
    3060 N S Q1n a bond Me a bond NH O a bond Q3f OH
    3061 N S Q1n a bond Me a bond NH O NH Q3a OH
    3062 N S Q1n a bond Me a bond NH O NH Q3d OH
    3063 N S Q1n a bond Me a bond NH O NH Q3e OH
    3064 N S Q1n a bond Me a bond NH O NH Q3f OH
    3065 N S Q1n a bond Me a bond NH S a bond Q3a OH
    3066 N S Q1n a bond Me a bond NH S a bond Q3d OH
    3067 N S Q1n a bond Me a bond NH S a bond Q3e OH
    3068 N S Q1n a bond Me a bond NH S a bond Q3f OH
    3069 N S Q1n a bond Me a bond NH S NH Q3a OH
    3070 N S Q1n a bond Me a bond NH S NH Q3d OH
    3071 N S Q1n a bond Me a bond NH S NH Q3e OH
    3072 N S Q1n a bond Me a bond NH S NH Q3f OH
    3073 N O Q1k a bond Me a bond NH O a bond Q3a OH
    3074 N O Q1k a bond Me a bond NH O a bond Q3d OH
    3075 N O Q1k a bond Me a bond NH O a bond Q3e OH
    3076 N O Q1k a bond Me a bond NH O a bond Q3f OH
    3077 N O Q1k a bond Me a bond NH O NH Q3a OH
    3078 N O Q1k a bond Me a bond NH O NH Q3d OH
    3079 N O Q1k a bond Me a bond NH O NH Q3e OH
    3080 N O Q1k a bond Me a bond NH O NH Q3f OH
    3081 N O Q1k a bond Me a bond NH S a bond Q3a OH
    3082 N O Q1k a bond Me a bond NH S a bond Q3d OH
    3083 N O Q1k a bond Me a bond NH S a bond Q3e OH
    3084 N O Q1k a bond Me a bond NH S a bond Q3f OH
    3085 N O Q1k a bond Me a bond NH S NH Q3a OH
    3086 N O Q1k a bond Me a bond NH S NH Q3d OH
    3087 N O Q1k a bond Me a bond NH S NH Q3e OH
    3088 N O Q1k a bond Me a bond NH S NH Q3f OH
    3089 N O Q1l a bond Me a bond NH O a bond Q3a OH
    3090 N O Q1l a bond Me a bond NH O a bond Q3d OH
    3091 N O Q1l a bond Me a bond NH O a bond Q3e OH
    3092 N O Q1l a bond Me a bond NH O a bond Q3f OH
    3093 N O Q1l a bond Me a bond NH O NH Q3a OH
    3094 N O Q1l a bond Me a bond NH O NH Q3d OH
    3095 N O Q1l a bond Me a bond NH O NH Q3e OH
    3096 N O Q1l a bond Me a bond NH O NH Q3f OH
    3097 N O Q1l a bond Me a bond NH S a bond Q3a OH
    3098 N O Q1l a bond Me a bond NH S a bond Q3d OH
    3099 N O Q1l a bond Me a bond NH S a bond Q3e OH
    3100 N O Q1l a bond Me a bond NH S a bond Q3f OH
    3101 N O Q1l a bond Me a bond NH S NH Q3a OH
    3102 N O Q1l a bond Me a bond NH S NH Q3d OH
    3103 N O Q1l a bond Me a bond NH S NH Q3e OH
    3104 N O Q1l a bond Me a bond NH S NH Q3f OH
    3105 N O Q1m a bond Me a bond NH O a bond Q3a OH
    3106 N O Q1m a bond Me a bond NH O a bond Q3d OH
    3107 N O Q1m a bond Me a bond NH O a bond Q3e OH
    3108 N O Q1m a bond Me a bond NH O a bond Q3f OH
    3109 N O Q1m a bond Me a bond NH O NH Q3a OH
    3110 N O Q1m a bond Me a bond NH O NH Q3d OH
    3111 N O Q1m a bond Me a bond NH O NH Q3e OH
    3112 N O Q1m a bond Me a bond NH O NH Q3f OH
    3113 N O Q1m a bond Me a bond NH S a bond Q3a OH
    3114 N O Q1m a bond Me a bond NH S a bond Q3d OH
    3115 N O Q1m a bond Me a bond NH S a bond Q3e OH
    3116 N O Q1m a bond Me a bond NH S a bond Q3f OH
    3117 N O Q1m a bond Me a bond NH S NH Q3a OH
    3118 N O Q1m a bond Me a bond NH S NH Q3d OH
    3119 N O Q1m a bond Me a bond NH S NH Q3e OH
    3120 N O Q1m a bond Me a bond NH S NH Q3f OH
    3121 N O Q1n a bond Me a bond NH O a bond Q3a OH
    3122 N O Q1n a bond Me a bond NH O a bond Q3d OH
    3123 N O Q1n a bond Me a bond NH O a bond Q3e OH
    3124 N O Q1n a bond Me a bond NH O a bond Q3f OH
    3125 N O Q1n a bond Me a bond NH O NH Q3a OH
    3126 N O Q1n a bond Me a bond NH O NH Q3d OH
    3127 N O Q1n a bond Me a bond NH O NH Q3e OH
    3128 N O Q1n a bond Me a bond NH O NH Q3f OH
    3129 N O Q1n a bond Me a bond NH S a bond Q3a OH
    3130 N O Q1n a bond Me a bond NH S a bond Q3d OH
    3131 N O Q1n a bond Me a bond NH S a bond Q3e OH
    3132 N O Q1n a bond Me a bond NH S a bond Q3f OH
    3133 N O Q1n a bond Me a bond NH S NH Q3a OH
    3134 N O Q1n a bond Me a bond NH S NH Q3d OH
    3135 N O Q1n a bond Me a bond NH S NH Q3e OH
    3136 N O Q1n a bond Me a bond NH S NH Q3f OH
    3137 CH NMe Q1k a bond Me a bond NH O a bond Q3a OH
    3138 CH NMe Q1k a bond Me a bond NH O a bond Q3d OH
    3139 CH NMe Q1k a bond Me a bond NH O a bond Q3e OH
    3140 CH NMe Q1k a bond Me a bond NH O a bond Q3f OH
    3141 CH NMe Q1k a bond Me a bond NH O NH Q3a OH
    3142 CH NMe Q1k a bond Me a bond NH O NH Q3d OH
    3143 CH NMe Q1k a bond Me a bond NH O NH Q3e OH
    3144 CH NMe Q1k a bond Me a bond NH O NH Q3f OH
    3145 CH NMe Q1k a bond Me a bond NH S a bond Q3a OH
    3146 CH NMe Q1k a bond Me a bond NH S a bond Q3d OH
    3147 CH NMe Q1k a bond Me a bond NH S a bond Q3e OH
    3148 CH NMe Q1k a bond Me a bond NH S a bond Q3f OH
    3149 CH NMe Q1k a bond Me a bond NH S NH Q3a OH
    3150 CH NMe Q1k a bond Me a bond NH S NH Q3d OH
    3151 CH NMe Q1k a bond Me a bond NH S NH Q3e OH
    3152 CH NMe Q1k a bond Me a bond NH S NH Q3f OH
    3153 CH NMe Q1l a bond Me a bond NH O a bond Q3a OH
    3154 CH NMe Q1l a bond Me a bond NH O a bond Q3d OH
    3155 CH NMe Q1l a bond Me a bond NH O a bond Q3e OH
    3156 CH NMe Q1l a bond Me a bond NH O a bond Q3f OH
    3157 CH NMe Q1l a bond Me a bond NH O NH Q3a OH
    3158 CH NMe Q1l a bond Me a bond NH O NH Q3d OH
    3159 CH NMe Q1l a bond Me a bond NH O NH Q3e OH
    3160 CH NMe Q1l a bond Me a bond NH O NH Q3f OH
    3161 CH NMe Q1l a bond Me a bond NH S a bond Q3a OH
    3162 CH NMe Q1l a bond Me a bond NH S a bond Q3d OH
    3163 CH NMe Q1l a bond Me a bond NH S a bond Q3e OH
    3164 CH NMe Q1l a bond Me a bond NH S a bond Q3f OH
    3165 CH NMe Q1l a bond Me a bond NH S NH Q3a OH
    3166 CH NMe Q1l a bond Me a bond NH S NH Q3d OH
    3167 CH NMe Q1l a bond Me a bond NH S NH Q3e OH
    3168 CH NMe Q1l a bond Me a bond NH S NH Q3f OH
    3169 CH NMe Q1m a bond Me a bond NH O a bond Q3a OH
    3170 CH NMe Q1m a bond Me a bond NH O a bond Q3d OH
    3171 CH NMe Q1m a bond Me a bond NH O a bond Q3e OH
    3172 CH NMe Q1m a bond Me a bond NH O a bond Q3f OH
    3173 CH NMe Q1m a bond Me a bond NH O NH Q3a OH
    3174 CH NMe Q1m a bond Me a bond NH O NH Q3d OH
    3175 CH NMe Q1m a bond Me a bond NH O NH Q3e OH
    3176 CH NMe Q1m a bond Me a bond NH O NH Q3f OH
    3177 CH NMe Q1m a bond Me a bond NH S a bond Q3a OH
    3178 CH NMe Q1m a bond Me a bond NH S a bond Q3d OH
    3179 CH NMe Q1m a bond Me a bond NH S a bond Q3e OH
    3180 CH NMe Q1m a bond Me a bond NH S a bond Q3f OH
    3181 CH NMe Q1m a bond Me a bond NH S NH Q3a OH
    3182 CH NMe Q1m a bond Me a bond NH S NH Q3d OH
    3183 CH NMe Q1m a bond Me a bond NH S NH Q3e OH
    3184 CH NMe Q1m a bond Me a bond NH S NH Q3f OH
    3185 CH NMe Q1n a bond Me a bond NH O a bond Q3a OH
    3186 CH NMe Q1n a bond Me a bond NH O a bond Q3d OH
    3187 CH NMe Q1n a bond Me a bond NH O a bond Q3e OH
    3188 CH NMe Q1n a bond Me a bond NH O a bond Q3f OH
    3189 CH NMe Q1n a bond Me a bond NH O NH Q3a OH
    3190 CH NMe Q1n a bond Me a bond NH O NH Q3d OH
    3191 CH NMe Q1n a bond Me a bond NH O NH Q3e OH
    3192 CH NMe Q1n a bond Me a bond NH O NH Q3f OH
    3193 CH NMe Q1n a bond Me a bond NH S a bond Q3a OH
    3194 CH NMe Q1n a bond Me a bond NH S a bond Q3d OH
    3195 CH NMe Q1n a bond Me a bond NH S a bond Q3e OH
    3196 CH NMe Q1n a bond Me a bond NH S a bond Q3f OH
    3197 CH NMe Q1n a bond Me a bond NH S NH Q3a OH
    3198 CH NMe Q1n a bond Me a bond NH S NH Q3d OH
    3199 CH NMe Q1n a bond Me a bond NH S NH Q3e OH
    3200 CH NMe Q1n a bond Me a bond NH S NH Q3f OH
    3201 CH NEt Q1k a bond Me a bond NH O a bond Q3a OH
    3202 CH NEt Q1k a bond Me a bond NH O a bond Q3d OH
    3203 CH NEt Q1k a bond Me a bond NH O a bond Q3e OH
    3204 CH NEt Q1k a bond Me a bond NH O a bond Q3f OH
    3205 CH NEt Q1k a bond Me a bond NH O NH Q3a OH
    3206 CH NEt Q1k a bond Me a bond NH O NH Q3d OH
    3207 CH NEt Q1k a bond Me a bond NH O NH Q3e OH
    3208 CH NEt Q1k a bond Me a bond NH O NH Q3f OH
    3209 CH NEt Q1k a bond Me a bond NH S a bond Q3a OH
    3210 CH NEt Q1k a bond Me a bond NH S a bond Q3d OH
    3211 CH NEt Q1k a bond Me a bond NH S a bond Q3e OH
    3212 CH NEt Q1k a bond Me a bond NH S a bond Q3f OH
    3213 CH NEt Q1k a bond Me a bond NH S NH Q3a OH
    3214 CH NEt Q1k a bond Me a bond NH S NH Q3d OH
    3215 CH NEt Q1k a bond Me a bond NH S NH Q3e OH
    3216 CH NEt Q1k a bond Me a bond NH S NH Q3f OH
    3217 CH NEt Q1l a bond Me a bond NH O a bond Q3a OH
    3218 CH NEt Q1l a bond Me a bond NH O a bond Q3d OH
    3219 CH NEt Q1l a bond Me a bond NH O a bond Q3e OH
    3220 CH NEt Q1l a bond Me a bond NH O a bond Q3f OH
    3221 CH NEt Q1l a bond Me a bond NH O NH Q3a OH
    3222 CH NEt Q1l a bond Me a bond NH O NH Q3d OH
    3223 CH NEt Q1l a bond Me a bond NH O NH Q3e OH
    3224 CH NEt Q1l a bond Me a bond NH O NH Q3f OH
    3225 CH NEt Q1l a bond Me a bond NH S a bond Q3a OH
    3226 CH NEt Q1l a bond Me a bond NH S a bond Q3d OH
    3227 CH NEt Q1l a bond Me a bond NH S a bond Q3e OH
    3228 CH NEt Q1l a bond Me a bond NH S a bond Q3f OH
    3229 CH NEt Q1l a bond Me a bond NH S NH Q3a OH
    3230 CH NEt Q1l a bond Me a bond NH S NH Q3d OH
    3231 CH NEt Q1l a bond Me a bond NH S NH Q3e OH
    3232 CH NEt Q1l a bond Me a bond NH S NH Q3f OH
    3233 CH NEt Q1m a bond Me a bond NH O a bond Q3a OH
    3234 CH NEt Q1m a bond Me a bond NH O a bond Q3d OH
    3235 CH NEt Q1m a bond Me a bond NH O a bond Q3e OH
    3236 CH NEt Q1m a bond Me a bond NH O a bond Q3f OH
    3237 CH NEt Q1m a bond Me a bond NH O NH Q3a OH
    3238 CH NEt Q1m a bond Me a bond NH O NH Q3d OH
    3239 CH NEt Q1m a bond Me a bond NH O NH Q3e OH
    3240 CH NEt Q1m a bond Me a bond NH O NH Q3f OH
    3241 CH NEt Q1m a bond Me a bond NH S a bond Q3a OH
    3242 CH NEt Q1m a bond Me a bond NH S a bond Q3d OH
    3243 CH NEt Q1m a bond Me a bond NH S a bond Q3e OH
    3244 CH NEt Q1m a bond Me a bond NH S a bond Q3f OH
    3245 CH NEt Q1m a bond Me a bond NH S NH Q3a OH
    3246 CH NEt Q1m a bond Me a bond NH S NH Q3d OH
    3247 CH NEt Q1m a bond Me a bond NH S NH Q3e OH
    3248 CH NEt Q1m a bond Me a bond NH S NH Q3f OH
    3249 CH NEt Q1n a bond Me a bond NH O a bond Q3a OH
    3250 CH NEt Q1n a bond Me a bond NH O a bond Q3d OH
    3251 CH NEt Q1n a bond Me a bond NH O a bond Q3e OH
    3252 CH NEt Q1n a bond Me a bond NH O a bond Q3f OH
    3253 CH NEt Q1n a bond Me a bond NH O NH Q3a OH
    3254 CH NEt Q1n a bond Me a bond NH O NH Q3d OH
    3255 CH NEt Q1n a bond Me a bond NH O NH Q3e OH
    3256 CH NEt Q1n a bond Me a bond NH O NH Q3f OH
    3257 CH NEt Q1n a bond Me a bond NH S a bond Q3a OH
    3258 CH NEt Q1n a bond Me a bond NH S a bond Q3d OH
    3259 CH NEt Q1n a bond Me a bond NH S a bond Q3e OH
    3260 CH NEt Q1n a bond Me a bond NH S a bond Q3f OH
    3261 CH NEt Q1n a bond Me a bond NH S NH Q3a OH
    3262 CH NEt Q1n a bond Me a bond NH S NH Q3d OH
    3263 CH NEt Q1n a bond Me a bond NH S NH Q3e OH
    3264 CH NEt Q1n a bond Me a bond NH S NH Q3f OH
    3265 CH S Q1k a bond Me a bond NH O a bond Q3a OH
    3266 CH S Q1k a bond Me a bond NH O a bond Q3d OH
    3267 CH S Q1k a bond Me a bond NH O a bond Q3e OH
    3268 CH S Q1k a bond Me a bond NH O a bond Q3f OH
    3269 CH S Q1k a bond Me a bond NH O NH Q3a OH
    3270 CH S Q1k a bond Me a bond NH O NH Q3d OH
    3271 CH S Q1k a bond Me a bond NH O NH Q3e OH
    3272 CH S Q1k a bond Me a bond NH O NH Q3f OH
    3273 CH S Q1k a bond Me a bond NH S a bond Q3a OH
    3274 CH S Q1k a bond Me a bond NH S a bond Q3d OH
    3275 CH S Q1k a bond Me a bond NH S a bond Q3e OH
    3276 CH S Q1k a bond Me a bond NH S a bond Q3f OH
    3277 CH S Q1k a bond Me a bond NH S NH Q3a OH
    3278 CH S Q1k a bond Me a bond NH S NH Q3d OH
    3279 CH S Q1k a bond Me a bond NH S NH Q3e OH
    3280 CH S Q1k a bond Me a bond NH S NH Q3f OH
    3281 CH S Q1l a bond Me a bond NH O a bond Q3a OH
    3282 CH S Q1l a bond Me a bond NH O a bond Q3d OH
    3283 CH S Q1l a bond Me a bond NH O a bond Q3e OH
    3284 CH S Q1l a bond Me a bond NH O a bond Q3f OH
    3285 CH S Q1l a bond Me a bond NH O NH Q3a OH
    3286 CH S Q1l a bond Me a bond NH O NH Q3d OH
    3287 CH S Q1l a bond Me a bond NH O NH Q3e OH
    3288 CH S Q1l a bond Me a bond NH O NH Q3f OH
    3289 CH S Q1l a bond Me a bond NH S a bond Q3a OH
    3290 CH S Q1l a bond Me a bond NH S a bond Q3d OH
    3291 CH S Q1l a bond Me a bond NH S a bond Q3e OH
    3292 CH S Q1l a bond Me a bond NH S a bond Q3f OH
    3293 CH S Q1l a bond Me a bond NH S NH Q3a OH
    3294 CH S Q1l a bond Me a bond NH S NH Q3d OH
    3295 CH S Q1l a bond Me a bond NH S NH Q3e OH
    3296 CH S Q1l a bond Me a bond NH S NH Q3f OH
    3297 CH S Q1m a bond Me a bond NH O a bond Q3a OH
    3298 CH S Q1m a bond Me a bond NH O a bond Q3d OH
    3299 CH S Q1m a bond Me a bond NH O a bond Q3e OH
    3300 CH S Q1m a bond Me a bond NH O a bond Q3f OH
    3301 CH S Q1m a bond Me a bond NH O NH Q3a OH
    3302 CH S Q1m a bond Me a bond NH O NH Q3d OH
    3303 CH S Q1m a bond Me a bond NH O NH Q3e OH
    3304 CH S Q1m a bond Me a bond NH O NH Q3f OH
    3305 CH S Q1m a bond Me a bond NH S a bond Q3a OH
    3306 CH S Q1m a bond Me a bond NH S a bond Q3d OH
    3307 CH S Q1m a bond Me a bond NH S a bond Q3e OH
    3308 CH S Q1m a bond Me a bond NH S a bond Q3f OH
    3309 CH S Q1m a bond Me a bond NH S NH Q3a OH
    3310 CH S Q1m a bond Me a bond NH S NH Q3d OH
    3311 CH S Q1m a bond Me a bond NH S NH Q3e OH
    3312 CH S Q1m a bond Me a bond NH S NH Q3f OH
    3313 CH S Q1n a bond Me a bond NH O a bond Q3a OH
    3314 CH S Q1n a bond Me a bond NH O a bond Q3d OH
    3315 CH S Q1n a bond Me a bond NH O a bond Q3e OH
    3316 CH S Q1n a bond Me a bond NH O a bond Q3f OH
    3317 CH S Q1n a bond Me a bond NH O NH Q3a OH
    3318 CH S Q1n a bond Me a bond NH O NH Q3d OH
    3319 CH S Q1n a bond Me a bond NH O NH Q3e OH
    3320 CH S Q1n a bond Me a bond NH O NH Q3f OH
    3321 CH S Q1n a bond Me a bond NH S a bond Q3a OH
    3322 CH S Q1n a bond Me a bond NH S a bond Q3d OH
    3323 CH S Q1n a bond Me a bond NH S a bond Q3e OH
    3324 CH S Q1n a bond Me a bond NH S a bond Q3f OH
    3325 CH S Q1n a bond Me a bond NH S NH Q3a OH
    3326 CH S Q1n a bond Me a bond NH S NH Q3d OH
    3327 CH S Q1n a bond Me a bond NH S NH Q3e OH
    3328 CH S Q1n a bond Me a bond NH S NH Q3f OH
    3329 CH O Q1k a bond Me a bond NH O a bond Q3a OH
    3330 CH O Q1k a bond Me a bond NH O a bond Q3d OH
    3331 CH O Q1k a bond Me a bond NH O a bond Q3e OH
    3332 CH O Q1k a bond Me a bond NH O a bond Q3f OH
    3333 CH O Q1k a bond Me a bond NH O NH Q3a OH
    3334 CH O Q1k a bond Me a bond NH O NH Q3d OH
    3335 CH O Q1k a bond Me a bond NH O NH Q3e OH
    3336 CH O Q1k a bond Me a bond NH O NH Q3f OH
    3337 CH O Q1k a bond Me a bond NH S a bond Q3a OH
    3338 CH O Q1k a bond Me a bond NH S a bond Q3d OH
    3339 CH O Q1k a bond Me a bond NH S a bond Q3e OH
    3340 CH O Q1k a bond Me a bond NH S a bond Q3f OH
    3341 CH O Q1k a bond Me a bond NH S NH Q3a OH
    3342 CH O Q1k a bond Me a bond NH S NH Q3d OH
    3343 CH O Q1k a bond Me a bond NH S NH Q3e OH
    3344 CH O Q1k a bond Me a bond NH S NH Q3f OH
    3345 CH O Q1l a bond Me a bond NH O a bond Q3a OH
    3346 CH O Q1l a bond Me a bond NH O a bond Q3d OH
    3347 CH O Q1l a bond Me a bond NH O a bond Q3e OH
    3348 CH O Q1l a bond Me a bond NH O a bond Q3f OH
    3349 CH O Q1l a bond Me a bond NH O NH Q3a OH
    3350 CH O Q1l a bond Me a bond NH O NH Q3d OH
    3351 CH O Q1l a bond Me a bond NH O NH Q3e OH
    3352 CH O Q1l a bond Me a bond NH O NH Q3f OH
    3353 CH O Q1l a bond Me a bond NH S a bond Q3a OH
    3354 CH O Q1l a bond Me a bond NH S a bond Q3d OH
    3355 CH O Q1l a bond Me a bond NH S a bond Q3e OH
    3356 CH O Q1l a bond Me a bond NH S a bond Q3f OH
    3357 CH O Q1l a bond Me a bond NH S NH Q3a OH
    3358 CH O Q1l a bond Me a bond NH S NH Q3d OH
    3359 CH O Q1l a bond Me a bond NH S NH Q3e OH
    3360 CH O Q1l a bond Me a bond NH S NH Q3f OH
    3361 CH O Q1m a bond Me a bond NH O a bond Q3a OH
    3362 CH O Q1m a bond Me a bond NH O a bond Q3d OH
    3363 CH O Q1m a bond Me a bond NH O a bond Q3e OH
    3364 CH O Q1m a bond Me a bond NH O a bond Q3f OH
    3365 CH O Q1m a bond Me a bond NH O NH Q3a OH
    3366 CH O Q1m a bond Me a bond NH O NH Q3d OH
    3367 CH O Q1m a bond Me a bond NH O NH Q3e OH
    3368 CH O Q1m a bond Me a bond NH O NH Q3f OH
    3369 CH O Q1m a bond Me a bond NH S a bond Q3a OH
    3370 CH O Q1m a bond Me a bond NH S a bond Q3d OH
    3371 CH O Q1m a bond Me a bond NH S a bond Q3e OH
    3372 CH O Q1m a bond Me a bond NH S a bond Q3f OH
    3373 CH O Q1m a bond Me a bond NH S NH Q3a OH
    3374 CH O Q1m a bond Me a bond NH S NH Q3d OH
    3375 CH O Q1m a bond Me a bond NH S NH Q3e OH
    3376 CH O Q1m a bond Me a bond NH S NH Q3f OH
    3377 CH O Q1n a bond Me a bond NH O a bond Q3a OH
    3378 CH O Q1n a bond Me a bond NH O a bond Q3d OH
    3379 CH O Q1n a bond Me a bond NH O a bond Q3e OH
    3380 CH O Q1n a bond Me a bond NH O a bond Q3f OH
    3381 CH O Q1n a bond Me a bond NH O NH Q3a OH
    3382 CH O Q1n a bond Me a bond NH O NH Q3d OH
    3383 CH O Q1n a bond Me a bond NH O NH Q3e OH
    3384 CH O Q1n a bond Me a bond NH O NH Q3f OH
    3385 CH O Q1n a bond Me a bond NH S a bond Q3a OH
    3386 CH O Q1n a bond Me a bond NH S a bond Q3d OH
    3387 CH O Q1n a bond Me a bond NH S a bond Q3e OH
    3388 CH O Q1n a bond Me a bond NH S a bond Q3f OH
    3389 CH O Q1n a bond Me a bond NH S NH Q3a OH
    3390 CH O Q1n a bond Me a bond NH S NH Q3d OH
    3391 CH O Q1n a bond Me a bond NH S NH Q3e OH
    3392 CH O Q1n a bond Me a bond NH S NH Q3f OH
    3393 CMe NMe Q1k a bond Me a bond NH O a bond Q3a OH
    3394 CMe NMe Q1k a bond Me a bond NH O a bond Q3d OH
    3395 CMe NMe Q1k a bond Me a bond NH O a bond Q3e OH
    3396 CMe NMe Q1k a bond Me a bond NH O a bond Q3f OH
    3397 CMe NMe Q1k a bond Me a bond NH O NH Q3a OH
    3398 CMe NMe Q1k a bond Me a bond NH O NH Q3d OH
    3399 CMe NMe Q1k a bond Me a bond NH O NH Q3e OH
    3400 CMe NMe Q1k a bond Me a bond NH O NH Q3f OH
    3401 CMe NMe Q1k a bond Me a bond NH S a bond Q3a OH
    3402 CMe NMe Q1k a bond Me a bond NH S a bond Q3d OH
    3403 CMe NMe Q1k a bond Me a bond NH S a bond Q3e OH
    3404 CMe NMe Q1k a bond Me a bond NH S a bond Q3f OH
    3405 CMe NMe Q1k a bond Me a bond NH S NH Q3a OH
    3406 CMe NMe Q1k a bond Me a bond NH S NH Q3d OH
    3407 CMe NMe Q1k a bond Me a bond NH S NH Q3e OH
    3408 CMe NMe Q1k a bond Me a bond NH S NH Q3f OH
    3409 CMe NMe Q1l a bond Me a bond NH O a bond Q3a OH
    3410 CMe NMe Q1l a bond Me a bond NH O a bond Q3d OH
    3411 CMe NMe Q1l a bond Me a bond NH O a bond Q3e OH
    3412 CMe NMe Q1l a bond Me a bond NH O a bond Q3f OH
    3413 CMe NMe Q1l a bond Me a bond NH O NH Q3a OH
    3414 CMe NMe Q1l a bond Me a bond NH O NH Q3d OH
    3415 CMe NMe Q1l a bond Me a bond NH O NH Q3e OH
    3416 CMe NMe Q1l a bond Me a bond NH O NH Q3f OH
    3417 CMe NMe Q1l a bond Me a bond NH S a bond Q3a OH
    3418 CMe NMe Q1l a bond Me a bond NH S a bond Q3d OH
    3419 CMe NMe Q1l a bond Me a bond NH S a bond Q3e OH
    3420 CMe NMe Q1l a bond Me a bond NH S a bond Q3f OH
    3421 CMe NMe Q1l a bond Me a bond NH S NH Q3a OH
    3422 CMe NMe Q1l a bond Me a bond NH S NH Q3d OH
    3423 CMe NMe Q1l a bond Me a bond NH S NH Q3e OH
    3424 CMe NMe Q1l a bond Me a bond NH S NH Q3f OH
    3425 CMe NMe Q1m a bond Me a bond NH O a bond Q3a OH
    3426 CMe NMe Q1m a bond Me a bond NH O a bond Q3d OH
    3427 CMe NMe Q1m a bond Me a bond NH O a bond Q3e OH
    3428 CMe NMe Q1m a bond Me a bond NH O a bond Q3f OH
    3429 CMe NMe Q1m a bond Me a bond NH O NH Q3a OH
    3430 CMe NMe Q1m a bond Me a bond NH O NH Q3d OH
    3431 CMe NMe Q1m a bond Me a bond NH O NH Q3e OH
    3432 CMe NMe Q1m a bond Me a bond NH O NH Q3f OH
    3433 CMe NMe Q1m a bond Me a bond NH S a bond Q3a OH
    3434 CMe NMe Q1m a bond Me a bond NH S a bond Q3d OH
    3435 CMe NMe Q1m a bond Me a bond NH S a bond Q3e OH
    3436 CMe NMe Q1m a bond Me a bond NH S a bond Q3f OH
    3437 CMe NMe Q1m a bond Me a bond NH S NH Q3a OH
    3438 CMe NMe Q1m a bond Me a bond NH S NH Q3d OH
    3439 CMe NMe Q1m a bond Me a bond NH S NH Q3e OH
    3440 CMe NMe Q1m a bond Me a bond NH S NH Q3f OH
    3441 CMe NMe Q1n a bond Me a bond NH O a bond Q3a OH
    3442 CMe NMe Q1n a bond Me a bond NH O a bond Q3d OH
    3443 CMe NMe Q1n a bond Me a bond NH O a bond Q3e OH
    3444 CMe NMe Q1n a bond Me a bond NH O a bond Q3f OH
    3445 CMe NMe Q1n a bond Me a bond NH O NH Q3a OH
    3446 CMe NMe Q1n a bond Me a bond NH O NH Q3d OH
    3447 CMe NMe Q1n a bond Me a bond NH O NH Q3e OH
    3448 CMe NMe Q1n a bond Me a bond NH O NH Q3f OH
    3449 CMe NMe Q1n a bond Me a bond NH S a bond Q3a OH
    3450 CMe NMe Q1n a bond Me a bond NH S a bond Q3d OH
    3451 CMe NMe Q1n a bond Me a bond NH S a bond Q3e OH
    3452 CMe NMe Q1n a bond Me a bond NH S a bond Q3f OH
    3453 CMe NMe Q1n a bond Me a bond NH S NH Q3a OH
    3454 CMe NMe Q1n a bond Me a bond NH S NH Q3d OH
    3455 CMe NMe Q1n a bond Me a bond NH S NH Q3e OH
    3456 CMe NMe Q1n a bond Me a bond NH S NH Q3f OH
    3457 CMe NEt Q1k a bond Me a bond NH O a bond Q3a OH
    3458 CMe NEt Q1k a bond Me a bond NH O a bond Q3d OH
    3459 CMe NEt Q1k a bond Me a bond NH O a bond Q3e OH
    3460 CMe NEt Q1k a bond Me a bond NH O a bond Q3f OH
    3461 CMe NEt Q1k a bond Me a bond NH O NH Q3a OH
    3462 CMe NEt Q1k a bond Me a bond NH O NH Q3d OH
    3463 CMe NEt Q1k a bond Me a bond NH O NH Q3e OH
    3464 CMe NEt Q1k a bond Me a bond NH O NH Q3f OH
    3465 CMe NEt Q1k a bond Me a bond NH S a bond Q3a OH
    3466 CMe NEt Q1k a bond Me a bond NH S a bond Q3d OH
    3467 CMe NEt Q1k a bond Me a bond NH S a bond Q3e OH
    3468 CMe NEt Q1k a bond Me a bond NH S a bond Q3f OH
    3469 CMe NEt Q1k a bond Me a bond NH S NH Q3a OH
    3470 CMe NEt Q1k a bond Me a bond NH S NH Q3d OH
    3471 CMe NEt Q1k a bond Me a bond NH S NH Q3e OH
    3472 CMe NEt Q1k a bond Me a bond NH S NH Q3f OH
    3473 CMe NEt Q1l a bond Me a bond NH O a bond Q3a OH
    3474 CMe NEt Q1l a bond Me a bond NH O a bond Q3d OH
    3475 CMe NEt Q1l a bond Me a bond NH O a bond Q3e OH
    3476 CMe NEt Q1l a bond Me a bond NH O a bond Q3f OH
    3477 CMe NEt Q1l a bond Me a bond NH O NH Q3a OH
    3478 CMe NEt Q1l a bond Me a bond NH O NH Q3d OH
    3479 CMe NEt Q1l a bond Me a bond NH O NH Q3e OH
    3480 CMe NEt Q1l a bond Me a bond NH O NH Q3f OH
    3481 CMe NEt Q1l a bond Me a bond NH S a bond Q3a OH
    3482 CMe NEt Q1l a bond Me a bond NH S a bond Q3d OH
    3483 CMe NEt Q1l a bond Me a bond NH S a bond Q3e OH
    3484 CMe NEt Q1l a bond Me a bond NH S a bond Q3f OH
    3485 CMe NEt Q1l a bond Me a bond NH S NH Q3a OH
    3486 CMe NEt Q1l a bond Me a bond NH S NH Q3d OH
    3487 CMe NEt Q1l a bond Me a bond NH S NH Q3e OH
    3488 CMe NEt Q1l a bond Me a bond NH S NH Q3f OH
    3489 CMe NEt Q1m a bond Me a bond NH O a bond Q3a OH
    3490 CMe NEt Q1m a bond Me a bond NH O a bond Q3d OH
    3491 CMe NEt Q1m a bond Me a bond NH O a bond Q3e OH
    3492 CMe NEt Q1m a bond Me a bond NH O a bond Q3f OH
    3493 CMe NEt Q1m a bond Me a bond NH O NH Q3a OH
    3494 CMe NEt Q1m a bond Me a bond NH O NH Q3d OH
    3495 CMe NEt Q1m a bond Me a bond NH O NH Q3e OH
    3496 CMe NEt Q1m a bond Me a bond NH O NH Q3f OH
    3497 CMe NEt Q1m a bond Me a bond NH S a bond Q3a OH
    3498 CMe NEt Q1m a bond Me a bond NH S a bond Q3d OH
    3499 CMe NEt Q1m a bond Me a bond NH S a bond Q3e OH
    3500 CMe NEt Q1m a bond Me a bond NH S a bond Q3f OH
    3501 CMe NEt Q1m a bond Me a bond NH S NH Q3a OH
    3502 CMe NEt Q1m a bond Me a bond NH S NH Q3d OH
    3503 CMe NEt Q1m a bond Me a bond NH S NH Q3e OH
    3504 CMe NEt Q1m a bond Me a bond NH S NH Q3f OH
    3505 CMe NEt Q1n a bond Me a bond NH O a bond Q3a OH
    3506 CMe NEt Q1n a bond Me a bond NH O a bond Q3d OH
    3507 CMe NEt Q1n a bond Me a bond NH O a bond Q3e OH
    3508 CMe NEt Q1n a bond Me a bond NH O a bond Q3f OH
    3509 CMe NEt Q1n a bond Me a bond NH O NH Q3a OH
    3510 CMe NEt Q1n a bond Me a bond NH O NH Q3d OH
    3511 CMe NEt Q1n a bond Me a bond NH O NH Q3e OH
    3512 CMe NEt Q1n a bond Me a bond NH O NH Q3f OH
    3513 CMe NEt Q1n a bond Me a bond NH S a bond Q3a OH
    3514 CMe NEt Q1n a bond Me a bond NH S a bond Q3d OH
    3515 CMe NEt Q1n a bond Me a bond NH S a bond Q3e OH
    3516 CMe NEt Q1n a bond Me a bond NH S a bond Q3f OH
    3517 CMe NEt Q1n a bond Me a bond NH S NH Q3a OH
    3518 CMe NEt Q1n a bond Me a bond NH S NH Q3d OH
    3519 CMe NEt Q1n a bond Me a bond NH S NH Q3e OH
    3520 CMe NEt Q1n a bond Me a bond NH S NH Q3f OH
    3521 CMe S Q1k a bond Me a bond NH O a bond Q3a OH
    3522 CMe S Q1k a bond Me a bond NH O a bond Q3d OH
    3523 CMe S Q1k a bond Me a bond NH O a bond Q3e OH
    3524 CMe S Q1k a bond Me a bond NH O a bond Q3f OH
    3525 CMe S Q1k a bond Me a bond NH O NH Q3a OH
    3526 CMe S Q1k a bond Me a bond NH O NH Q3d OH
    3527 CMe S Q1k a bond Me a bond NH O NH Q3e OH
    3528 CMe S Q1k a bond Me a bond NH O NH Q3f OH
    3529 CMe S Q1k a bond Me a bond NH S a bond Q3a OH
    3530 CMe S Q1k a bond Me a bond NH S a bond Q3d OH
    3531 CMe S Q1k a bond Me a bond NH S a bond Q3e OH
    3532 CMe S Q1k a bond Me a bond NH S a bond Q3f OH
    3533 CMe S Q1k a bond Me a bond NH S NH Q3a OH
    3534 CMe S Q1k a bond Me a bond NH S NH Q3d OH
    3535 CMe S Q1k a bond Me a bond NH S NH Q3e OH
    3536 CMe S Q1k a bond Me a bond NH S NH Q3f OH
    3537 CMe S Q1l a bond Me a bond NH O a bond Q3a OH
    3538 CMe S Q1l a bond Me a bond NH O a bond Q3d OH
    3539 CMe S Q1l a bond Me a bond NH O a bond Q3e OH
    3540 CMe S Q1l a bond Me a bond NH O a bond Q3f OH
    3541 CMe S Q1l a bond Me a bond NH O NH Q3a OH
    3542 CMe S Q1l a bond Me a bond NH O NH Q3d OH
    3543 CMe S Q1l a bond Me a bond NH O NH Q3e OH
    3544 CMe S Q1l a bond Me a bond NH O NH Q3f OH
    3545 CMe S Q1l a bond Me a bond NH S a bond Q3a OH
    3546 CMe S Q1l a bond Me a bond NH S a bond Q3d OH
    3547 CMe S Q1l a bond Me a bond NH S a bond Q3e OH
    3548 CMe S Q1l a bond Me a bond NH S a bond Q3f OH
    3549 CMe S Q1l a bond Me a bond NH S NH Q3a OH
    3550 CMe S Q1l a bond Me a bond NH S NH Q3d OH
    3551 CMe S Q1l a bond Me a bond NH S NH Q3e OH
    3552 CMe S Q1l a bond Me a bond NH S NH Q3f OH
    3553 CMe S Q1m a bond Me a bond NH O a bond Q3a OH
    3554 CMe S Q1m a bond Me a bond NH O a bond Q3d OH
    3555 CMe S Q1m a bond Me a bond NH O a bond Q3e OH
    3556 CMe S Q1m a bond Me a bond NH O a bond Q3f OH
    3557 CMe S Q1m a bond Me a bond NH O NH Q3a OH
    3558 CMe S Q1m a bond Me a bond NH O NH Q3d OH
    3559 CMe S Q1m a bond Me a bond NH O NH Q3e OH
    3560 CMe S Q1m a bond Me a bond NH O NH Q3f OH
    3561 CMe S Q1m a bond Me a bond NH S a bond Q3a OH
    3562 CMe S Q1m a bond Me a bond NH S a bond Q3d OH
    3563 CMe S Q1m a bond Me a bond NH S a bond Q3e OH
    3564 CMe S Q1m a bond Me a bond NH S a bond Q3f OH
    3565 CMe S Q1m a bond Me a bond NH S NH Q3a OH
    3566 CMe S Q1m a bond Me a bond NH S NH Q3d OH
    3567 CMe S Q1m a bond Me a bond NH S NH Q3e OH
    3568 CMe S Q1m a bond Me a bond NH S NH Q3f OH
    3569 CMe S Q1n a bond Me a bond NH O a bond Q3a OH
    3570 CMe S Q1n a bond Me a bond NH O a bond Q3d OH
    3571 CMe S Q1n a bond Me a bond NH O a bond Q3e OH
    3572 CMe S Q1n a bond Me a bond NH O a bond Q3f OH
    3573 CMe S Q1n a bond Me a bond NH O NH Q3a OH
    3574 CMe S Q1n a bond Me a bond NH O NH Q3d OH
    3575 CMe S Q1n a bond Me a bond NH O NH Q3e OH
    3576 CMe S Q1n a bond Me a bond NH O NH Q3f OH
    3577 CMe S Q1n a bond Me a bond NH S a bond Q3a OH
    3578 CMe S Q1n a bond Me a bond NH S a bond Q3d OH
    3579 CMe S Q1n a bond Me a bond NH S a bond Q3e OH
    3580 CMe S Q1n a bond Me a bond NH S a bond Q3f OH
    3581 CMe S Q1n a bond Me a bond NH S NH Q3a OH
    3582 CMe S Q1n a bond Me a bond NH S NH Q3d OH
    3583 CMe S Q1n a bond Me a bond NH S NH Q3e OH
    3584 CMe S Q1n a bond Me a bond NH S NH Q3f OH
    3585 CMe O Q1k a bond Me a bond NH O a bond Q3a OH
    3586 CMe O Q1k a bond Me a bond NH O a bond Q3d OH
    3587 CMe O Q1k a bond Me a bond NH O a bond Q3e OH
    3588 CMe O Q1k a bond Me a bond NH O a bond Q3f OH
    3589 CMe O Q1k a bond Me a bond NH O NH Q3a OH
    3590 CMe O Q1k a bond Me a bond NH O NH Q3d OH
    3591 CMe O Q1k a bond Me a bond NH O NH Q3e OH
    3592 CMe O Q1k a bond Me a bond NH O NH Q3f OH
    3593 CMe O Q1k a bond Me a bond NH S a bond Q3a OH
    3594 CMe O Q1k a bond Me a bond NH S a bond Q3d OH
    3595 CMe O Q1k a bond Me a bond NH S a bond Q3e OH
    3596 CMe O Q1k a bond Me a bond NH S a bond Q3f OH
    3597 CMe O Q1k a bond Me a bond NH S NH Q3a OH
    3598 CMe O Q1k a bond Me a bond NH S NH Q3d OH
    3599 CMe O Q1k a bond Me a bond NH S NH Q3e OH
    3600 CMe O Q1k a bond Me a bond NH S NH Q3f OH
    3601 CMe O Q1l a bond Me a bond NH O a bond Q3a OH
    3602 CMe O Q1l a bond Me a bond NH O a bond Q3d OH
    3603 CMe O Q1l a bond Me a bond NH O a bond Q3e OH
    3604 CMe O Q1l a bond Me a bond NH O a bond Q3f OH
    3605 CMe O Q1l a bond Me a bond NH O NH Q3a OH
    3606 CMe O Q1l a bond Me a bond NH O NH Q3d OH
    3607 CMe O Q1l a bond Me a bond NH O NH Q3e OH
    3608 CMe O Q1l a bond Me a bond NH O NH Q3f OH
    3609 CMe O Q1l a bond Me a bond NH S a bond Q3a OH
    3610 CMe O Q1l a bond Me a bond NH S a bond Q3d OH
    3611 CMe O Q1l a bond Me a bond NH S a bond Q3e OH
    3612 CMe O Q1l a bond Me a bond NH S a bond Q3f OH
    3613 CMe O Q1l a bond Me a bond NH S NH Q3a OH
    3614 CMe O Q1l a bond Me a bond NH S NH Q3d OH
    3615 CMe O Q1l a bond Me a bond NH S NH Q3e OH
    3616 CMe O Q1l a bond Me a bond NH S NH Q3f OH
    3617 CMe O Q1m a bond Me a bond NH O a bond Q3a OH
    3618 CMe O Q1m a bond Me a bond NH O a bond Q3d OH
    3619 CMe O Q1m a bond Me a bond NH O a bond Q3e OH
    3620 CMe O Q1m a bond Me a bond NH O a bond Q3f OH
    3621 CMe O Q1m a bond Me a bond NH O NH Q3a OH
    3622 CMe O Q1m a bond Me a bond NH O NH Q3d OH
    3623 CMe O Q1m a bond Me a bond NH O NH Q3e OH
    3624 CMe O Q1m a bond Me a bond NH O NH Q3f OH
    3625 CMe O Q1m a bond Me a bond NH S a bond Q3a OH
    3626 CMe O Q1m a bond Me a bond NH S a bond Q3d OH
    3627 CMe O Q1m a bond Me a bond NH S a bond Q3e OH
    3628 CMe O Q1m a bond Me a bond NH S a bond Q3f OH
    3629 CMe O Q1m a bond Me a bond NH S NH Q3a OH
    3630 CMe O Q1m a bond Me a bond NH S NH Q3d OH
    3631 CMe O Q1m a bond Me a bond NH S NH Q3e OH
    3632 CMe O Q1m a bond Me a bond NH S NH Q3f OH
    3633 CMe O Q1n a bond Me a bond NH O a bond Q3a OH
    3634 CMe O Q1n a bond Me a bond NH O a bond Q3d OH
    3635 CMe O Q1n a bond Me a bond NH O a bond Q3e OH
    3636 CMe O Q1n a bond Me a bond NH O a bond Q3f OH
    3637 CMe O Q1n a bond Me a bond NH O NH Q3a OH
    3638 CMe O Q1n a bond Me a bond NH O NH Q3d OH
    3639 CMe O Q1n a bond Me a bond NH O NH Q3e OH
    3640 CMe O Q1n a bond Me a bond NH O NH Q3f OH
    3641 CMe O Q1n a bond Me a bond NH S a bond Q3a OH
    3642 CMe O Q1n a bond Me a bond NH S a bond Q3d OH
    3643 CMe O Q1n a bond Me a bond NH S a bond Q3e OH
    3644 CMe O Q1n a bond Me a bond NH S a bond Q3f OH
    3645 CMe O Q1n a bond Me a bond NH S NH Q3a OH
    3646 CMe O Q1n a bond Me a bond NH S NH Q3d OH
    3647 CMe O Q1n a bond Me a bond NH S NH Q3e OH
    3648 CMe O Q1n a bond Me a bond NH S NH Q3f OH
    3649 N NMe Q1k′ a bond Me a bond NH O a bond Q3a OH
    3650 N NMe Q1k′ a bond Me a bond NH O a bond Q3d OH
    3651 N NMe Q1k′ a bond Me a bond NH O a bond Q3e OH
    3652 N NMe Q1k′ a bond Me a bond NH O a bond Q3f OH
    3653 N NMe Q1k′ a bond Me a bond NH O NH Q3a OH
    3654 N NMe Q1k′ a bond Me a bond NH O NH Q3d OH
    3655 N NMe Q1k′ a bond Me a bond NH O NH Q3e OH
    3656 N NMe Q1k′ a bond Me a bond NH O NH Q3f OH
    3657 N NMe Q1k′ a bond Me a bond NH S a bond Q3a OH
    3658 N NMe Q1k′ a bond Me a bond NH S a bond Q3d OH
    3659 N NMe Q1k′ a bond Me a bond NH S a bond Q3e OH
    3660 N NMe Q1k′ a bond Me a bond NH S a bond Q3f OH
    3661 N NMe Q1k′ a bond Me a bond NH S NH Q3a OH
    3662 N NMe Q1k′ a bond Me a bond NH S NH Q3d OH
    3663 N NMe Q1k′ a bond Me a bond NH S NH Q3e OH
    3664 N NMe Q1k′ a bond Me a bond NH S NH Q3f OH
    3665 N NMe Q1l′ a bond Me a bond NH O a bond Q3a OH
    3666 N NMe Q1l′ a bond Me a bond NH O a bond Q3d OH
    3667 N NMe Q1l′ a bond Me a bond NH O a bond Q3e OH
    3668 N NMe Q1l′ a bond Me a bond NH O a bond Q3f OH
    3669 N NMe Q1l′ a bond Me a bond NH O NH Q3a OH
    3670 N NMe Q1l′ a bond Me a bond NH O NH Q3d OH
    3671 N NMe Q1l′ a bond Me a bond NH O NH Q3e OH
    3672 N NMe Q1l′ a bond Me a bond NH O NH Q3f OH
    3673 N NMe Q1l′ a bond Me a bond NH S a bond Q3a OH
    3674 N NMe Q1l′ a bond Me a bond NH S a bond Q3d OH
    3675 N NMe Q1l′ a bond Me a bond NH S a bond Q3e OH
    3676 N NMe Q1l′ a bond Me a bond NH S a bond Q3f OH
    3677 N NMe Q1l′ a bond Me a bond NH S NH Q3a OH
    3678 N NMe Q1l′ a bond Me a bond NH S NH Q3d OH
    3679 N NMe Q1l′ a bond Me a bond NH S NH Q3e OH
    3680 N NMe Q1l′ a bond Me a bond NH S NH Q3f OH
    3681 N NMe Q1m′ a bond Me a bond NH O a bond Q3a OH
    3682 N NMe Q1m′ a bond Me a bond NH O a bond Q3d OH
    3683 N NMe Q1m′ a bond Me a bond NH O a bond Q3e OH
    3684 N NMe Q1m′ a bond Me a bond NH O a bond Q3f OH
    3685 N NMe Q1m′ a bond Me a bond NH O NH Q3a OH
    3686 N NMe Q1m′ a bond Me a bond NH O NH Q3d OH
    3687 N NMe Q1m′ a bond Me a bond NH O NH Q3e OH
    3688 N NMe Q1m′ a bond Me a bond NH O NH Q3f OH
    3689 N NMe Q1m′ a bond Me a bond NH S a bond Q3a OH
    3690 N NMe Q1m′ a bond Me a bond NH S a bond Q3d OH
    3691 N NMe Q1m′ a bond Me a bond NH S a bond Q3e OH
    3692 N NMe Q1m′ a bond Me a bond NH S a bond Q3f OH
    3693 N NMe Q1m′ a bond Me a bond NH S NH Q3a OH
    3694 N NMe Q1m′ a bond Me a bond NH S NH Q3d OH
    3695 N NMe Q1m′ a bond Me a bond NH S NH Q3e OH
    3696 N NMe Q1m′ a bond Me a bond NH S NH Q3f OH
    3697 N NMe Q1n′ a bond Me a bond NH O a bond Q3a OH
    3698 N NMe Q1n′ a bond Me a bond NH O a bond Q3d OH
    3699 N NMe Q1n′ a bond Me a bond NH O a bond Q3e OH
    3700 N NMe Q1n′ a bond Me a bond NH O a bond Q3f OH
    3701 N NMe Q1n′ a bond Me a bond NH O NH Q3a OH
    3702 N NMe Q1n′ a bond Me a bond NH O NH Q3d OH
    3703 N NMe Q1n′ a bond Me a bond NH O NH Q3e OH
    3704 N NMe Q1n′ a bond Me a bond NH O NH Q3f OH
    3705 N NMe Q1n′ a bond Me a bond NH S a bond Q3a OH
    3706 N NMe Q1n′ a bond Me a bond NH S a bond Q3d OH
    3707 N NMe Q1n′ a bond Me a bond NH S a bond Q3e OH
    3708 N NMe Q1n′ a bond Me a bond NH S a bond Q3f OH
    3709 N NMe Q1n′ a bond Me a bond NH S NH Q3a OH
    3710 N NMe Q1n′ a bond Me a bond NH S NH Q3d OH
    3711 N NMe Q1n′ a bond Me a bond NH S NH Q3e OH
    3712 N NMe Q1n′ a bond Me a bond NH S NH Q3f OH
    3713 N NEt Q1k′ a bond Me a bond NH O a bond Q3a OH
    3714 N NEt Q1k′ a bond Me a bond NH O a bond Q3d OH
    3715 N NEt Q1k′ a bond Me a bond NH O a bond Q3e OH
    3716 N NEt Q1k′ a bond Me a bond NH O a bond Q3f OH
    3717 N NEt Q1k′ a bond Me a bond NH O NH Q3a OH
    3718 N NEt Q1k′ a bond Me a bond NH O NH Q3d OH
    3719 N NEt Q1k′ a bond Me a bond NH O NH Q3e OH
    3720 N NEt Q1k′ a bond Me a bond NH O NH Q3f OH
    3721 N NEt Q1k′ a bond Me a bond NH S a bond Q3a OH
    3722 N NEt Q1k′ a bond Me a bond NH S a bond Q3d OH
    3723 N NEt Q1k′ a bond Me a bond NH S a bond Q3e OH
    3724 N NEt Q1k′ a bond Me a bond NH S a bond Q3f OH
    3725 N NEt Q1k′ a bond Me a bond NH S NH Q3a OH
    3726 N NEt Q1k′ a bond Me a bond NH S NH Q3d OH
    3727 N NEt Q1k′ a bond Me a bond NH S NH Q3e OH
    3728 N NEt Q1k′ a bond Me a bond NH S NH Q3f OH
    3729 N NEt Q1l′ a bond Me a bond NH O a bond Q3a OH
    3730 N NEt Q1l′ a bond Me a bond NH O a bond Q3d OH
    3731 N NEt Q1l′ a bond Me a bond NH O a bond Q3e OH
    3732 N NEt Q1l′ a bond Me a bond NH O a bond Q3f OH
    3733 N NEt Q1l′ a bond Me a bond NH O NH Q3a OH
    3734 N NEt Q1l′ a bond Me a bond NH O NH Q3d OH
    3735 N NEt Q1l′ a bond Me a bond NH O NH Q3e OH
    3736 N NEt Q1l′ a bond Me a bond NH O NH Q3f OH
    3737 N NEt Q1l′ a bond Me a bond NH S a bond Q3a OH
    3738 N NEt Q1l′ a bond Me a bond NH S a bond Q3d OH
    3739 N NEt Q1l′ a bond Me a bond NH S a bond Q3e OH
    3740 N NEt Q1l′ a bond Me a bond NH S a bond Q3f OH
    3741 N NEt Q1l′ a bond Me a bond NH S NH Q3a OH
    3742 N NEt Q1l′ a bond Me a bond NH S NH Q3d OH
    3743 N NEt Q1l′ a bond Me a bond NH S NH Q3e OH
    3744 N NEt Q1l′ a bond Me a bond NH S NH Q3f OH
    3745 N NEt Q1m′ a bond Me a bond NH O a bond Q3a OH
    3746 N NEt Q1m′ a bond Me a bond NH O a bond Q3d OH
    3747 N NEt Q1m′ a bond Me a bond NH O a bond Q3e OH
    3748 N NEt Q1m′ a bond Me a bond NH O a bond Q3f OH
    3749 N NEt Q1m′ a bond Me a bond NH O NH Q3a OH
    3750 N NEt Q1m′ a bond Me a bond NH O NH Q3d OH
    3751 N NEt Q1m′ a bond Me a bond NH O NH Q3e OH
    3752 N NEt Q1m′ a bond Me a bond NH O NH Q3f OH
    3753 N NEt Q1m′ a bond Me a bond NH S a bond Q3a OH
    3754 N NEt Q1m′ a bond Me a bond NH S a bond Q3d OH
    3755 N NEt Q1m′ a bond Me a bond NH S a bond Q3e OH
    3756 N NEt Q1m′ a bond Me a bond NH S a bond Q3f OH
    3757 N NEt Q1m′ a bond Me a bond NH S NH Q3a OH
    3758 N NEt Q1m′ a bond Me a bond NH S NH Q3d OH
    3759 N NEt Q1m′ a bond Me a bond NH S NH Q3e OH
    3760 N NEt Q1m′ a bond Me a bond NH S NH Q3f OH
    3761 N NEt Q1n′ a bond Me a bond NH O a bond Q3a OH
    3762 N NEt Q1n′ a bond Me a bond NH O a bond Q3d OH
    3763 N NEt Q1n′ a bond Me a bond NH O a bond Q3e OH
    3764 N NEt Q1n′ a bond Me a bond NH O a bond Q3f OH
    3765 N NEt Q1n′ a bond Me a bond NH O NH Q3a OH
    3766 N NEt Q1n′ a bond Me a bond NH O NH Q3d OH
    3767 N NEt Q1n′ a bond Me a bond NH O NH Q3e OH
    3768 N NEt Q1n′ a bond Me a bond NH O NH Q3f OH
    3769 N NEt Q1n′ a bond Me a bond NH S a bond Q3a OH
    3770 N NEt Q1n′ a bond Me a bond NH S a bond Q3d OH
    3771 N NEt Q1n′ a bond Me a bond NH S a bond Q3e OH
    3772 N NEt Q1n′ a bond Me a bond NH S a bond Q3f OH
    3773 N NEt Q1n′ a bond Me a bond NH S NH Q3a OH
    3774 N NEt Q1n′ a bond Me a bond NH S NH Q3d OH
    3775 N NEt Q1n′ a bond Me a bond NH S NH Q3e OH
    3776 N NEt Q1n′ a bond Me a bond NH S NH Q3f OH
    3777 N S Q1k′ a bond Me a bond NH O a bond Q3a OH
    3778 N S Q1k′ a bond Me a bond NH O a bond Q3d OH
    3779 N S Q1k′ a bond Me a bond NH O a bond Q3e OH
    3780 N S Q1k′ a bond Me a bond NH O a bond Q3f OH
    3781 N S Q1k′ a bond Me a bond NH O NH Q3a OH
    3782 N S Q1k′ a bond Me a bond NH O NH Q3d OH
    3783 N S Q1k′ a bond Me a bond NH O NH Q3e OH
    3784 N S Q1k′ a bond Me a bond NH O NH Q3f OH
    3785 N S Q1k′ a bond Me a bond NH S a bond Q3a OH
    3786 N S Q1k′ a bond Me a bond NH S a bond Q3d OH
    3787 N S Q1k′ a bond Me a bond NH S a bond Q3e OH
    3788 N S Q1k′ a bond Me a bond NH S a bond Q3f OH
    3789 N S Q1k′ a bond Me a bond NH S NH Q3a OH
    3790 N S Q1k′ a bond Me a bond NH S NH Q3d OH
    3791 N S Q1k′ a bond Me a bond NH S NH Q3e OH
    3792 N S Q1k′ a bond Me a bond NH S NH Q3f OH
    3793 N S Q1l′ a bond Me a bond NH O a bond Q3a OH
    3794 N S Q1l′ a bond Me a bond NH O a bond Q3d OH
    3795 N S Q1l′ a bond Me a bond NH O a bond Q3e OH
    3796 N S Q1l′ a bond Me a bond NH O a bond Q3f OH
    3797 N S Q1l′ a bond Me a bond NH O NH Q3a OH
    3798 N S Q1l′ a bond Me a bond NH O NH Q3d OH
    3799 N S Q1l′ a bond Me a bond NH O NH Q3e OH
    3800 N S Q1l′ a bond Me a bond NH O NH Q3f OH
    3801 N S Q1l′ a bond Me a bond NH S a bond Q3a OH
    3802 N S Q1l′ a bond Me a bond NH S a bond Q3d OH
    3803 N S Q1l′ a bond Me a bond NH S a bond Q3e OH
    3804 N S Q1l′ a bond Me a bond NH S a bond Q3f OH
    3805 N S Q1l′ a bond Me a bond NH S NH Q3a OH
    3806 N S Q1l′ a bond Me a bond NH S NH Q3d OH
    3807 N S Q1l′ a bond Me a bond NH S NH Q3e OH
    3808 N S Q1l′ a bond Me a bond NH S NH Q3f OH
    3809 N S Q1m′ a bond Me a bond NH O a bond Q3a OH
    3810 N S Q1m′ a bond Me a bond NH O a bond Q3d OH
    3811 N S Q1m′ a bond Me a bond NH O a bond Q3e OH
    3812 N S Q1m′ a bond Me a bond NH O a bond Q3f OH
    3813 N S Q1m′ a bond Me a bond NH O NH Q3a OH
    3814 N S Q1m′ a bond Me a bond NH O NH Q3d OH
    3815 N S Q1m′ a bond Me a bond NH O NH Q3e OH
    3816 N S Q1m′ a bond Me a bond NH O NH Q3f OH
    3817 N S Q1m′ a bond Me a bond NH S a bond Q3a OH
    3818 N S Q1m′ a bond Me a bond NH S a bond Q3d OH
    3819 N S Q1m′ a bond Me a bond NH S a bond Q3e OH
    3820 N S Q1m′ a bond Me a bond NH S a bond Q3f OH
    3821 N S Q1m′ a bond Me a bond NH S NH Q3a OH
    3822 N S Q1m′ a bond Me a bond NH S NH Q3d OH
    3823 N S Q1m′ a bond Me a bond NH S NH Q3e OH
    3824 N S Q1m′ a bond Me a bond NH S NH Q3f OH
    3825 N S Q1n′ a bond Me a bond NH O a bond Q3a OH
    3826 N S Q1n′ a bond Me a bond NH O a bond Q3d OH
    3827 N S Q1n′ a bond Me a bond NH O a bond Q3e OH
    3828 N S Q1n′ a bond Me a bond NH O a bond Q3f OH
    3829 N S Q1n′ a bond Me a bond NH O NH Q3a OH
    3830 N S Q1n′ a bond Me a bond NH O NH Q3d OH
    3831 N S Q1n′ a bond Me a bond NH O NH Q3e OH
    3832 N S Q1n′ a bond Me a bond NH O NH Q3f OH
    3833 N S Q1n′ a bond Me a bond NH S a bond Q3a OH
    3834 N S Q1n′ a bond Me a bond NH S a bond Q3d OH
    3835 N S Q1n′ a bond Me a bond NH S a bond Q3e OH
    3836 N S Q1n′ a bond Me a bond NH S a bond Q3f OH
    3837 N S Q1n′ a bond Me a bond NH S NH Q3a OH
    3838 N S Q1n′ a bond Me a bond NH S NH Q3d OH
    3839 N S Q1n′ a bond Me a bond NH S NH Q3e OH
    3840 N S Q1n′ a bond Me a bond NH S NH Q3f OH
    3841 N O Q1k′ a bond Me a bond NH O a bond Q3a OH
    3842 N O Q1k′ a bond Me a bond NH O a bond Q3d OH
    3843 N O Q1k′ a bond Me a bond NH O a bond Q3e OH
    3844 N O Q1k′ a bond Me a bond NH O a bond Q3f OH
    3845 N O Q1k′ a bond Me a bond NH O NH Q3a OH
    3846 N O Q1k′ a bond Me a bond NH O NH Q3d OH
    3847 N O Q1k′ a bond Me a bond NH O NH Q3e OH
    3848 N O Q1k′ a bond Me a bond NH O NH Q3f OH
    3849 N O Q1k′ a bond Me a bond NH S a bond Q3a OH
    3850 N O Q1k′ a bond Me a bond NH S a bond Q3d OH
    3851 N O Q1k′ a bond Me a bond NH S a bond Q3e OH
    3852 N O Q1k′ a bond Me a bond NH S a bond Q3f OH
    3853 N O Q1k′ a bond Me a bond NH S NH Q3a OH
    3854 N O Q1k′ a bond Me a bond NH S NH Q3d OH
    3855 N O Q1k′ a bond Me a bond NH S NH Q3e OH
    3856 N O Q1k′ a bond Me a bond NH S NH Q3f OH
    3857 N O Q1l′ a bond Me a bond NH O a bond Q3a OH
    3858 N O Q1l′ a bond Me a bond NH O a bond Q3d OH
    3859 N O Q1l′ a bond Me a bond NH O a bond Q3e OH
    3860 N O Q1l′ a bond Me a bond NH O a bond Q3f OH
    3861 N O Q1l′ a bond Me a bond NH O NH Q3a OH
    3862 N O Q1l′ a bond Me a bond NH O NH Q3d OH
    3863 N O Q1l′ a bond Me a bond NH O NH Q3e OH
    3864 N O Q1l′ a bond Me a bond NH O NH Q3f OH
    3865 N O Q1l′ a bond Me a bond NH S a bond Q3a OH
    3866 N O Q1l′ a bond Me a bond NH S a bond Q3d OH
    3867 N O Q1l′ a bond Me a bond NH S a bond Q3e OH
    3868 N O Q1l′ a bond Me a bond NH S a bond Q3f OH
    3869 N O Q1l′ a bond Me a bond NH S NH Q3a OH
    3870 N O Q1l′ a bond Me a bond NH S NH Q3d OH
    3871 N O Q1l′ a bond Me a bond NH S NH Q3e OH
    3872 N O Q1l′ a bond Me a bond NH S NH Q3f OH
    3873 N O Q1m′ a bond Me a bond NH O a bond Q3a OH
    3874 N O Q1m′ a bond Me a bond NH O a bond Q3d OH
    3875 N O Q1m′ a bond Me a bond NH O a bond Q3e OH
    3876 N O Q1m′ a bond Me a bond NH O a bond Q3f OH
    3877 N O Q1m′ a bond Me a bond NH O NH Q3a OH
    3878 N O Q1m′ a bond Me a bond NH O NH Q3d OH
    3879 N O Q1m′ a bond Me a bond NH O NH Q3e OH
    3880 N O Q1m′ a bond Me a bond NH O NH Q3f OH
    3881 N O Q1m′ a bond Me a bond NH S a bond Q3a OH
    3882 N O Q1m′ a bond Me a bond NH S a bond Q3d OH
    3883 N O Q1m′ a bond Me a bond NH S a bond Q3e OH
    3884 N O Q1m′ a bond Me a bond NH S a bond Q3f OH
    3885 N O Q1m′ a bond Me a bond NH S NH Q3a OH
    3886 N O Q1m′ a bond Me a bond NH S NH Q3d OH
    3887 N O Q1m′ a bond Me a bond NH S NH Q3e OH
    3888 N O Q1m′ a bond Me a bond NH S NH Q3f OH
    3889 N O Q1n′ a bond Me a bond NH O a bond Q3a OH
    3890 N O Q1n′ a bond Me a bond NH O a bond Q3d OH
    3891 N O Q1n′ a bond Me a bond NH O a bond Q3e OH
    3892 N O Q1n′ a bond Me a bond NH O a bond Q3f OH
    3893 N O Q1n′ a bond Me a bond NH O NH Q3a OH
    3894 N O Q1n′ a bond Me a bond NH O NH Q3d OH
    3895 N O Q1n′ a bond Me a bond NH O NH Q3e OH
    3896 N O Q1n′ a bond Me a bond NH O NH Q3f OH
    3897 N O Q1n′ a bond Me a bond NH S a bond Q3a OH
    3898 N O Q1n′ a bond Me a bond NH S a bond Q3d OH
    3899 N O Q1n′ a bond Me a bond NH S a bond Q3e OH
    3900 N O Q1n′ a bond Me a bond NH S a bond Q3f OH
    3901 N O Q1n′ a bond Me a bond NH S NH Q3a OH
    3902 N O Q1n′ a bond Me a bond NH S NH Q3d OH
    3903 N O Q1n′ a bond Me a bond NH S NH Q3e OH
    3904 N O Q1n′ a bond Me a bond NH S NH Q3f OH
    3905 CH NMe Q1k′ a bond Me a bond NH O a bond Q3a OH
    3906 CH NMe Q1k′ a bond Me a bond NH O a bond Q3d OH
    3907 CH NMe Q1k′ a bond Me a bond NH O a bond Q3e OH
    3908 CH NMe Q1k′ a bond Me a bond NH O a bond Q3f OH
    3909 CH NMe Q1k′ a bond Me a bond NH O NH Q3a OH
    3910 CH NMe Q1k′ a bond Me a bond NH O NH Q3d OH
    3911 CH NMe Q1k′ a bond Me a bond NH O NH Q3e OH
    3912 CH NMe Q1k′ a bond Me a bond NH O NH Q3f OH
    3913 CH NMe Q1k′ a bond Me a bond NH S a bond Q3a OH
    3914 CH NMe Q1k′ a bond Me a bond NH S a bond Q3d OH
    3915 CH NMe Q1k′ a bond Me a bond NH S a bond Q3e OH
    3916 CH NMe Q1k′ a bond Me a bond NH S a bond Q3f OH
    3917 CH NMe Q1k′ a bond Me a bond NH S NH Q3a OH
    3918 CH NMe Q1k′ a bond Me a bond NH S NH Q3d OH
    3919 CH NMe Q1k′ a bond Me a bond NH S NH Q3e OH
    3920 CH NMe Q1k′ a bond Me a bond NH S NH Q3f OH
    3921 CH NMe Q1l′ a bond Me a bond NH O a bond Q3a OH
    3922 CH NMe Q1l′ a bond Me a bond NH O a bond Q3d OH
    3923 CH NMe Q1l′ a bond Me a bond NH O a bond Q3e OH
    3924 CH NMe Q1l′ a bond Me a bond NH O a bond Q3f OH
    3925 CH NMe Q1l′ a bond Me a bond NH O NH Q3a OH
    3926 CH NMe Q1l′ a bond Me a bond NH O NH Q3d OH
    3927 CH NMe Q1l′ a bond Me a bond NH O NH Q3e OH
    3928 CH NMe Q1l′ a bond Me a bond NH O NH Q3f OH
    3929 CH NMe Q1l′ a bond Me a bond NH S a bond Q3a OH
    3930 CH NMe Q1l′ a bond Me a bond NH S a bond Q3d OH
    3931 CH NMe Q1l′ a bond Me a bond NH S a bond Q3e OH
    3932 CH NMe Q1l′ a bond Me a bond NH S a bond Q3f OH
    3933 CH NMe Q1l′ a bond Me a bond NH S NH Q3a OH
    3934 CH NMe Q1l′ a bond Me a bond NH S NH Q3d OH
    3935 CH NMe Q1l′ a bond Me a bond NH S NH Q3e OH
    3936 CH NMe Q1l′ a bond Me a bond NH S NH Q3f OH
    3937 CH NMe Q1m′ a bond Me a bond NH O a bond Q3a OH
    3938 CH NMe Q1m′ a bond Me a bond NH O a bond Q3d OH
    3939 CH NMe Q1m′ a bond Me a bond NH O a bond Q3e OH
    3940 CH NMe Q1m′ a bond Me a bond NH O a bond Q3f OH
    3941 CH NMe Q1m′ a bond Me a bond NH O NH Q3a OH
    3942 CH NMe Q1m′ a bond Me a bond NH O NH Q3d OH
    3943 CH NMe Q1m′ a bond Me a bond NH O NH Q3e OH
    3944 CH NMe Q1m′ a bond Me a bond NH O NH Q3f OH
    3945 CH NMe Q1m′ a bond Me a bond NH S a bond Q3a OH
    3946 CH NMe Q1m′ a bond Me a bond NH S a bond Q3d OH
    3947 CH NMe Q1m′ a bond Me a bond NH S a bond Q3e OH
    3948 CH NMe Q1m′ a bond Me a bond NH S a bond Q3f OH
    3949 CH NMe Q1m′ a bond Me a bond NH S NH Q3a OH
    3950 CH NMe Q1m′ a bond Me a bond NH S NH Q3d OH
    3951 CH NMe Q1m′ a bond Me a bond NH S NH Q3e OH
    3952 CH NMe Q1m′ a bond Me a bond NH S NH Q3f OH
    3953 CH NMe Q1n′ a bond Me a bond NH O a bond Q3a OH
    3954 CH NMe Q1n′ a bond Me a bond NH O a bond Q3d OH
    3955 CH NMe Q1n′ a bond Me a bond NH O a bond Q3e OH
    3956 CH NMe Q1n′ a bond Me a bond NH O a bond Q3f OH
    3957 CH NMe Q1n′ a bond Me a bond NH O NH Q3a OH
    3958 CH NMe Q1n′ a bond Me a bond NH O NH Q3d OH
    3959 CH NMe Q1n′ a bond Me a bond NH O NH Q3e OH
    3960 CH NMe Q1n′ a bond Me a bond NH O NH Q3f OH
    3961 CH NMe Q1n′ a bond Me a bond NH S a bond Q3a OH
    3962 CH NMe Q1n′ a bond Me a bond NH S a bond Q3d OH
    3963 CH NMe Q1n′ a bond Me a bond NH S a bond Q3e OH
    3964 CH NMe Q1n′ a bond Me a bond NH S a bond Q3f OH
    3965 CH NMe Q1n′ a bond Me a bond NH S NH Q3a OH
    3966 CH NMe Q1n′ a bond Me a bond NH S NH Q3d OH
    3967 CH NMe Q1n′ a bond Me a bond NH S NH Q3e OH
    3968 CH NMe Q1n′ a bond Me a bond NH S NH Q3f OH
    3969 CH NEt Q1k′ a bond Me a bond NH O a bond Q3a OH
    3970 CH NEt Q1k′ a bond Me a bond NH O a bond Q3d OH
    3971 CH NEt Q1k′ a bond Me a bond NH O a bond Q3e OH
    3972 CH NEt Q1k′ a bond Me a bond NH O a bond Q3f OH
    3973 CH NEt Q1k′ a bond Me a bond NH O NH Q3a OH
    3974 CH NEt Q1k′ a bond Me a bond NH O NH Q3d OH
    3975 CH NEt Q1k′ a bond Me a bond NH O NH Q3e OH
    3976 CH NEt Q1k′ a bond Me a bond NH O NH Q3f OH
    3977 CH NEt Q1k′ a bond Me a bond NH S a bond Q3a OH
    3978 CH NEt Q1k′ a bond Me a bond NH S a bond Q3d OH
    3979 CH NEt Q1k′ a bond Me a bond NH S a bond Q3e OH
    3980 CH NEt Q1k′ a bond Me a bond NH S a bond Q3f OH
    3981 CH NEt Q1k′ a bond Me a bond NH S NH Q3a OH
    3982 CH NEt Q1k′ a bond Me a bond NH S NH Q3d OH
    3983 CH NEt Q1k′ a bond Me a bond NH S NH Q3e OH
    3984 CH NEt Q1k′ a bond Me a bond NH S NH Q3f OH
    3985 CH NEt Q1l′ a bond Me a bond NH O a bond Q3a OH
    3986 CH NEt Q1l′ a bond Me a bond NH O a bond Q3d OH
    3987 CH NEt Q1l′ a bond Me a bond NH O a bond Q3e OH
    3988 CH NEt Q1l′ a bond Me a bond NH O a bond Q3f OH
    3989 CH NEt Q1l′ a bond Me a bond NH O NH Q3a OH
    3990 CH NEt Q1l′ a bond Me a bond NH O NH Q3d OH
    3991 CH NEt Q1l′ a bond Me a bond NH O NH Q3e OH
    3992 CH NEt Q1l′ a bond Me a bond NH O NH Q3f OH
    3993 CH NEt Q1l′ a bond Me a bond NH S a bond Q3a OH
    3994 CH NEt Q1l′ a bond Me a bond NH S a bond Q3d OH
    3995 CH NEt Q1l′ a bond Me a bond NH S a bond Q3e OH
    3996 CH NEt Q1l′ a bond Me a bond NH S a bond Q3f OH
    3997 CH NEt Q1l′ a bond Me a bond NH S NH Q3a OH
    3998 CH NEt Q1l′ a bond Me a bond NH S NH Q3d OH
    3999 CH NEt Q1l′ a bond Me a bond NH S NH Q3e OH
    4000 CH NEt Q1l′ a bond Me a bond NH S NH Q3f OH
    4001 CH NEt Q1m′ a bond Me a bond NH O a bond Q3a OH
    4002 CH NEt Q1m′ a bond Me a bond NH O a bond Q3d OH
    4003 CH NEt Q1m′ a bond Me a bond NH O a bond Q3e OH
    4004 CH NEt Q1m′ a bond Me a bond NH O a bond Q3f OH
    4005 CH NEt Q1m′ a bond Me a bond NH O NH Q3a OH
    4006 CH NEt Q1m′ a bond Me a bond NH O NH Q3d OH
    4007 CH NEt Q1m′ a bond Me a bond NH O NH Q3e OH
    4008 CH NEt Q1m′ a bond Me a bond NH O NH Q3f OH
    4009 CH NEt Q1m′ a bond Me a bond NH S a bond Q3a OH
    4010 CH NEt Q1m′ a bond Me a bond NH S a bond Q3d OH
    4011 CH NEt Q1m′ a bond Me a bond NH S a bond Q3e OH
    4012 CH NEt Q1m′ a bond Me a bond NH S a bond Q3f OH
    4013 CH NEt Q1m′ a bond Me a bond NH S NH Q3a OH
    4014 CH NEt Q1m′ a bond Me a bond NH S NH Q3d OH
    4015 CH NEt Q1m′ a bond Me a bond NH S NH Q3e OH
    4016 CH NEt Q1m′ a bond Me a bond NH S NH Q3f OH
    4017 CH NEt Q1n′ a bond Me a bond NH O a bond Q3a OH
    4018 CH NEt Q1n′ a bond Me a bond NH O a bond Q3d OH
    4019 CH NEt Q1n′ a bond Me a bond NH O a bond Q3e OH
    4020 CH NEt Q1n′ a bond Me a bond NH O a bond Q3f OH
    4021 CH NEt Q1n′ a bond Me a bond NH O NH Q3a OH
    4022 CH NEt Q1n′ a bond Me a bond NH O NH Q3d OH
    4023 CH NEt Q1n′ a bond Me a bond NH O NH Q3e OH
    4024 CH NEt Q1n′ a bond Me a bond NH O NH Q3f OH
    4025 CH NEt Q1n′ a bond Me a bond NH S a bond Q3a OH
    4026 CH NEt Q1n′ a bond Me a bond NH S a bond Q3d OH
    4027 CH NEt Q1n′ a bond Me a bond NH S a bond Q3e OH
    4028 CH NEt Q1n′ a bond Me a bond NH S a bond Q3f OH
    4029 CH NEt Q1n′ a bond Me a bond NH S NH Q3a OH
    4030 CH NEt Q1n′ a bond Me a bond NH S NH Q3d OH
    4031 CH NEt Q1n′ a bond Me a bond NH S NH Q3e OH
    4032 CH NEt Q1n′ a bond Me a bond NH S NH Q3f OH
    4033 CH S Q1k′ a bond Me a bond NH O a bond Q3a OH
    4034 CH S Q1k′ a bond Me a bond NH O a bond Q3d OH
    4035 CH S Q1k′ a bond Me a bond NH O a bond Q3e OH
    4036 CH S Q1k′ a bond Me a bond NH O a bond Q3f OH
    4037 CH S Q1k′ a bond Me a bond NH O NH Q3a OH
    4038 CH S Q1k′ a bond Me a bond NH O NH Q3d OH
    4039 CH S Q1k′ a bond Me a bond NH O NH Q3e OH
    4040 CH S Q1k′ a bond Me a bond NH O NH Q3f OH
    4041 CH S Q1k′ a bond Me a bond NH S a bond Q3a OH
    4042 CH S Q1k′ a bond Me a bond NH S a bond Q3d OH
    4043 CH S Q1k′ a bond Me a bond NH S a bond Q3e OH
    4044 CH S Q1k′ a bond Me a bond NH S a bond Q3f OH
    4045 CH S Q1k′ a bond Me a bond NH S NH Q3a OH
    4046 CH S Q1k′ a bond Me a bond NH S NH Q3d OH
    4047 CH S Q1k′ a bond Me a bond NH S NH Q3e OH
    4048 CH S Q1k′ a bond Me a bond NH S NH Q3f OH
    4049 CH S Q1l′ a bond Me a bond NH O a bond Q3a OH
    4050 CH S Q1l′ a bond Me a bond NH O a bond Q3d OH
    4051 CH S Q1l′ a bond Me a bond NH O a bond Q3e OH
    4052 CH S Q1l′ a bond Me a bond NH O a bond Q3f OH
    4053 CH S Q1l′ a bond Me a bond NH O NH Q3a OH
    4054 CH S Q1l′ a bond Me a bond NH O NH Q3d OH
    4055 CH S Q1l′ a bond Me a bond NH O NH Q3e OH
    4056 CH S Q1l′ a bond Me a bond NH O NH Q3f OH
    4057 CH S Q1l′ a bond Me a bond NH S a bond Q3a OH
    4058 CH S Q1l′ a bond Me a bond NH S a bond Q3d OH
    4059 CH S Q1l′ a bond Me a bond NH S a bond Q3e OH
    4060 CH S Q1l′ a bond Me a bond NH S a bond Q3f OH
    4061 CH S Q1l′ a bond Me a bond NH S NH Q3a OH
    4062 CH S Q1l′ a bond Me a bond NH S NH Q3d OH
    4063 CH S Q1l′ a bond Me a bond NH S NH Q3e OH
    4064 CH S Q1l′ a bond Me a bond NH S NH Q3f OH
    4065 CH S Q1m′ a bond Me a bond NH O a bond Q3a OH
    4066 CH S Q1m′ a bond Me a bond NH O a bond Q3d OH
    4067 CH S Q1m′ a bond Me a bond NH O a bond Q3e OH
    4068 CH S Q1m′ a bond Me a bond NH O a bond Q3f OH
    4069 CH S Q1m′ a bond Me a bond NH O NH Q3a OH
    4070 CH S Q1m′ a bond Me a bond NH O NH Q3d OH
    4071 CH S Q1m′ a bond Me a bond NH O NH Q3e OH
    4072 CH S Q1m′ a bond Me a bond NH O NH Q3f OH
    4073 CH S Q1m′ a bond Me a bond NH S a bond Q3a OH
    4074 CH S Q1m′ a bond Me a bond NH S a bond Q3d OH
    4075 CH S Q1m′ a bond Me a bond NH S a bond Q3e OH
    4076 CH S Q1m′ a bond Me a bond NH S a bond Q3f OH
    4077 CH S Q1m′ a bond Me a bond NH S NH Q3a OH
    4078 CH S Q1m′ a bond Me a bond NH S NH Q3d OH
    4079 CH S Q1m′ a bond Me a bond NH S NH Q3e OH
    4080 CH S Q1m′ a bond Me a bond NH S NH Q3f OH
    4081 CH S Q1n′ a bond Me a bond NH O a bond Q3a OH
    4082 CH S Q1n′ a bond Me a bond NH O a bond Q3d OH
    4083 CH S Q1n′ a bond Me a bond NH O a bond Q3e OH
    4084 CH S Q1n′ a bond Me a bond NH O a bond Q3f OH
    4085 CH S Q1n′ a bond Me a bond NH O NH Q3a OH
    4086 CH S Q1n′ a bond Me a bond NH O NH Q3d OH
    4087 CH S Q1n′ a bond Me a bond NH O NH Q3e OH
    4088 CH S Q1n′ a bond Me a bond NH O NH Q3f OH
    4089 CH S Q1n′ a bond Me a bond NH S a bond Q3a OH
    4090 CH S Q1n′ a bond Me a bond NH S a bond Q3d OH
    4091 CH S Q1n′ a bond Me a bond NH S a bond Q3e OH
    4092 CH S Q1n′ a bond Me a bond NH S a bond Q3f OH
    4093 CH S Q1n′ a bond Me a bond NH S NH Q3a OH
    4094 CH S Q1n′ a bond Me a bond NH S NH Q3d OH
    4095 CH S Q1n′ a bond Me a bond NH S NH Q3e OH
    4096 CH S Q1n′ a bond Me a bond NH S NH Q3f OH
    4097 CH O Q1k′ a bond Me a bond NH O a bond Q3a OH
    4098 CH O Q1k′ a bond Me a bond NH O a bond Q3d OH
    4099 CH O Q1k′ a bond Me a bond NH O a bond Q3e OH
    4100 CH O Q1k′ a bond Me a bond NH O a bond Q3f OH
    4101 CH O Q1k′ a bond Me a bond NH O NH Q3a OH
    4102 CH O Q1k′ a bond Me a bond NH O NH Q3d OH
    4103 CH O Q1k′ a bond Me a bond NH O NH Q3e OH
    4104 CH O Q1k′ a bond Me a bond NH O NH Q3f OH
    4105 CH O Q1k′ a bond Me a bond NH S a bond Q3a OH
    4106 CH O Q1k′ a bond Me a bond NH S a bond Q3d OH
    4107 CH O Q1k′ a bond Me a bond NH S a bond Q3e OH
    4108 CH O Q1k′ a bond Me a bond NH S a bond Q3f OH
    4109 CH O Q1k′ a bond Me a bond NH S NH Q3a OH
    4110 CH O Q1k′ a bond Me a bond NH S NH Q3d OH
    4111 CH O Q1k′ a bond Me a bond NH S NH Q3e OH
    4112 CH O Q1k′ a bond Me a bond NH S NH Q3f OH
    4113 CH O Q1l′ a bond Me a bond NH O a bond Q3a OH
    4114 CH O Q1l′ a bond Me a bond NH O a bond Q3d OH
    4115 CH O Q1l′ a bond Me a bond NH O a bond Q3e OH
    4116 CH O Q1l′ a bond Me a bond NH O a bond Q3f OH
    4117 CH O Q1l′ a bond Me a bond NH O NH Q3a OH
    4118 CH O Q1l′ a bond Me a bond NH O NH Q3d OH
    4119 CH O Q1l′ a bond Me a bond NH O NH Q3e OH
    4120 CH O Q1l′ a bond Me a bond NH O NH Q3f OH
    4121 CH O Q1l′ a bond Me a bond NH S a bond Q3a OH
    4122 CH O Q1l′ a bond Me a bond NH S a bond Q3d OH
    4123 CH O Q1l′ a bond Me a bond NH S a bond Q3e OH
    4124 CH O Q1l′ a bond Me a bond NH S a bond Q3f OH
    4125 CH O Q1l′ a bond Me a bond NH S NH Q3a OH
    4126 CH O Q1l′ a bond Me a bond NH S NH Q3d OH
    4127 CH O Q1l′ a bond Me a bond NH S NH Q3e OH
    4128 CH O Q1l′ a bond Me a bond NH S NH Q3f OH
    4129 CH O Q1m′ a bond Me a bond NH O a bond Q3a OH
    4130 CH O Q1m′ a bond Me a bond NH O a bond Q3d OH
    4131 CH O Q1m′ a bond Me a bond NH O a bond Q3e OH
    4132 CH O Q1m′ a bond Me a bond NH O a bond Q3f OH
    4133 CH O Q1m′ a bond Me a bond NH O NH Q3a OH
    4134 CH O Q1m′ a bond Me a bond NH O NH Q3d OH
    4135 CH O Q1m′ a bond Me a bond NH O NH Q3e OH
    4136 CH O Q1m′ a bond Me a bond NH O NH Q3f OH
    4137 CH O Q1m′ a bond Me a bond NH S a bond Q3a OH
    4138 CH O Q1m′ a bond Me a bond NH S a bond Q3d OH
    4139 CH O Q1m′ a bond Me a bond NH S a bond Q3e OH
    4140 CH O Q1m′ a bond Me a bond NH S a bond Q3f OH
    4141 CH O Q1m′ a bond Me a bond NH S NH Q3a OH
    4142 CH O Q1m′ a bond Me a bond NH S NH Q3d OH
    4143 CH O Q1m′ a bond Me a bond NH S NH Q3e OH
    4144 CH O Q1m′ a bond Me a bond NH S NH Q3f OH
    4145 CH O Q1n′ a bond Me a bond NH O a bond Q3a OH
    4146 CH O Q1n′ a bond Me a bond NH O a bond Q3d OH
    4147 CH O Q1n′ a bond Me a bond NH O a bond Q3e OH
    4148 CH O Q1n′ a bond Me a bond NH O a bond Q3f OH
    4149 CH O Q1n′ a bond Me a bond NH O NH Q3a OH
    4150 CH O Q1n′ a bond Me a bond NH O NH Q3d OH
    4151 CH O Q1n′ a bond Me a bond NH O NH Q3e OH
    4152 CH O Q1n′ a bond Me a bond NH O NH Q3f OH
    4153 CH O Q1n′ a bond Me a bond NH S a bond Q3a OH
    4154 CH O Q1n′ a bond Me a bond NH S a bond Q3d OH
    4155 CH O Q1n′ a bond Me a bond NH S a bond Q3e OH
    4156 CH O Q1n′ a bond Me a bond NH S a bond Q3f OH
    4157 CH O Q1n′ a bond Me a bond NH S NH Q3a OH
    4158 CH O Q1n′ a bond Me a bond NH S NH Q3d OH
    4159 CH O Q1n′ a bond Me a bond NH S NH Q3e OH
    4160 CH O Q1n′ a bond Me a bond NH S NH Q3f OH
    4161 CMe NMe Q1k′ a bond Me a bond NH O a bond Q3a OH
    4162 CMe NMe Q1k′ a bond Me a bond NH O a bond Q3d OH
    4163 CMe NMe Q1k′ a bond Me a bond NH O a bond Q3e OH
    4164 CMe NMe Q1k′ a bond Me a bond NH O a bond Q3f OH
    4165 CMe NMe Q1k′ a bond Me a bond NH O NH Q3a OH
    4166 CMe NMe Q1k′ a bond Me a bond NH O NH Q3d OH
    4167 CMe NMe Q1k′ a bond Me a bond NH O NH Q3e OH
    4168 CMe NMe Q1k′ a bond Me a bond NH O NH Q3f OH
    4169 CMe NMe Q1k′ a bond Me a bond NH S a bond Q3a OH
    4170 CMe NMe Q1k′ a bond Me a bond NH S a bond Q3d OH
    4171 CMe NMe Q1k′ a bond Me a bond NH S a bond Q3e OH
    4172 CMe NMe Q1k′ a bond Me a bond NH S a bond Q3f OH
    4173 CMe NMe Q1k′ a bond Me a bond NH S NH Q3a OH
    4174 CMe NMe Q1k′ a bond Me a bond NH S NH Q3d OH
    4175 CMe NMe Q1k′ a bond Me a bond NH S NH Q3e OH
    4176 CMe NMe Q1k′ a bond Me a bond NH S NH Q3f OH
    4177 CMe NMe Q1l′ a bond Me a bond NH O a bond Q3a OH
    4178 CMe NMe Q1l′ a bond Me a bond NH O a bond Q3d OH
    4179 CMe NMe Q1l′ a bond Me a bond NH O a bond Q3e OH
    4180 CMe NMe Q1l′ a bond Me a bond NH O a bond Q3f OH
    4181 CMe NMe Q1l′ a bond Me a bond NH O NH Q3a OH
    4182 CMe NMe Q1l′ a bond Me a bond NH O NH Q3d OH
    4183 CMe NMe Q1l′ a bond Me a bond NH O NH Q3e OH
    4184 CMe NMe Q1l′ a bond Me a bond NH O NH Q3f OH
    4185 CMe NMe Q1l′ a bond Me a bond NH S a bond Q3a OH
    4186 CMe NMe Q1l′ a bond Me a bond NH S a bond Q3d OH
    4187 CMe NMe Q1l′ a bond Me a bond NH S a bond Q3e OH
    4188 CMe NMe Q1l′ a bond Me a bond NH S a bond Q3f OH
    4189 CMe NMe Q1l′ a bond Me a bond NH S NH Q3a OH
    4190 CMe NMe Q1l′ a bond Me a bond NH S NH Q3d OH
    4191 CMe NMe Q1l′ a bond Me a bond NH S NH Q3e OH
    4192 CMe NMe Q1l′ a bond Me a bond NH S NH Q3f OH
    4193 CMe NMe Q1m′ a bond Me a bond NH O a bond Q3a OH
    4194 CMe NMe Q1m′ a bond Me a bond NH O a bond Q3d OH
    4195 CMe NMe Q1m′ a bond Me a bond NH O a bond Q3e OH
    4196 CMe NMe Q1m′ a bond Me a bond NH O a bond Q3f OH
    4197 CMe NMe Q1m′ a bond Me a bond NH O NH Q3a OH
    4198 CMe NMe Q1m′ a bond Me a bond NH O NH Q3d OH
    4199 CMe NMe Q1m′ a bond Me a bond NH O NH Q3e OH
    4200 CMe NMe Q1m′ a bond Me a bond NH O NH Q3f OH
    4201 CMe NMe Q1m′ a bond Me a bond NH S a bond Q3a OH
    4202 CMe NMe Q1m′ a bond Me a bond NH S a bond Q3d OH
    4203 CMe NMe Q1m′ a bond Me a bond NH S a bond Q3e OH
    4204 CMe NMe Q1m′ a bond Me a bond NH S a bond Q3f OH
    4205 CMe NMe Q1m′ a bond Me a bond NH S NH Q3a OH
    4206 CMe NMe Q1m′ a bond Me a bond NH S NH Q3d OH
    4207 CMe NMe Q1m′ a bond Me a bond NH S NH Q3e OH
    4208 CMe NMe Q1m′ a bond Me a bond NH S NH Q3f OH
    4209 CMe NMe Q1n′ a bond Me a bond NH O a bond Q3a OH
    4210 CMe NMe Q1n′ a bond Me a bond NH O a bond Q3d OH
    4211 CMe NMe Q1n′ a bond Me a bond NH O a bond Q3e OH
    4212 CMe NMe Q1n′ a bond Me a bond NH O a bond Q3f OH
    4213 CMe NMe Q1n′ a bond Me a bond NH O NH Q3a OH
    4214 CMe NMe Q1n′ a bond Me a bond NH O NH Q3d OH
    4215 CMe NMe Q1n′ a bond Me a bond NH O NH Q3e OH
    4216 CMe NMe Q1n′ a bond Me a bond NH O NH Q3f OH
    4217 CMe NMe Q1n′ a bond Me a bond NH S a bond Q3a OH
    4218 CMe NMe Q1n′ a bond Me a bond NH S a bond Q3d OH
    4219 CMe NMe Q1n′ a bond Me a bond NH S a bond Q3e OH
    4220 CMe NMe Q1n′ a bond Me a bond NH S a bond Q3f OH
    4221 CMe NMe Q1n′ a bond Me a bond NH S NH Q3a OH
    4222 CMe NMe Q1n′ a bond Me a bond NH S NH Q3d OH
    4223 CMe NMe Q1n′ a bond Me a bond NH S NH Q3e OH
    4224 CMe NMe Q1n′ a bond Me a bond NH S NH Q3f OH
    4225 CMe NEt Q1k′ a bond Me a bond NH O a bond Q3a OH
    4226 CMe NEt Q1k′ a bond Me a bond NH O a bond Q3d OH
    4227 CMe NEt Q1k′ a bond Me a bond NH O a bond Q3e OH
    4228 CMe NEt Q1k′ a bond Me a bond NH O a bond Q3f OH
    4229 CMe NEt Q1k′ a bond Me a bond NH O NH Q3a OH
    4230 CMe NEt Q1k′ a bond Me a bond NH O NH Q3d OH
    4231 CMe NEt Q1k′ a bond Me a bond NH O NH Q3e OH
    4232 CMe NEt Q1k′ a bond Me a bond NH O NH Q3f OH
    4233 CMe NEt Q1k′ a bond Me a bond NH S a bond Q3a OH
    4234 CMe NEt Q1k′ a bond Me a bond NH S a bond Q3d OH
    4235 CMe NEt Q1k′ a bond Me a bond NH S a bond Q3e OH
    4236 CMe NEt Q1k′ a bond Me a bond NH S a bond Q3f OH
    4237 CMe NEt Q1k′ a bond Me a bond NH S NH Q3a OH
    4238 CMe NEt Q1k′ a bond Me a bond NH S NH Q3d OH
    4239 CMe NEt Q1k′ a bond Me a bond NH S NH Q3e OH
    4240 CMe NEt Q1k′ a bond Me a bond NH S NH Q3f OH
    4241 CMe NEt Q1l′ a bond Me a bond NH O a bond Q3a OH
    4242 CMe NEt Q1l′ a bond Me a bond NH O a bond Q3d OH
    4243 CMe NEt Q1l′ a bond Me a bond NH O a bond Q3e OH
    4244 CMe NEt Q1l′ a bond Me a bond NH O a bond Q3f OH
    4245 CMe NEt Q1l′ a bond Me a bond NH O NH Q3a OH
    4246 CMe NEt Q1l′ a bond Me a bond NH O NH Q3d OH
    4247 CMe NEt Q1l′ a bond Me a bond NH O NH Q3e OH
    4248 CMe NEt Q1l′ a bond Me a bond NH O NH Q3f OH
    4249 CMe NEt Q1l′ a bond Me a bond NH S a bond Q3a OH
    4250 CMe NEt Q1l′ a bond Me a bond NH S a bond Q3d OH
    4251 CMe NEt Q1l′ a bond Me a bond NH S a bond Q3e OH
    4252 CMe NEt Q1l′ a bond Me a bond NH S a bond Q3f OH
    4253 CMe NEt Q1l′ a bond Me a bond NH S NH Q3a OH
    4254 CMe NEt Q1l′ a bond Me a bond NH S NH Q3d OH
    4255 CMe NEt Q1l′ a bond Me a bond NH S NH Q3e OH
    4256 CMe NEt Q1l′ a bond Me a bond NH S NH Q3f OH
    4257 CMe NEt Q1m′ a bond Me a bond NH O a bond Q3a OH
    4258 CMe NEt Q1m′ a bond Me a bond NH O a bond Q3d OH
    4259 CMe NEt Q1m′ a bond Me a bond NH O a bond Q3e OH
    4260 CMe NEt Q1m′ a bond Me a bond NH O a bond Q3f OH
    4261 CMe NEt Q1m′ a bond Me a bond NH O NH Q3a OH
    4262 CMe NEt Q1m′ a bond Me a bond NH O NH Q3d OH
    4263 CMe NEt Q1m′ a bond Me a bond NH O NH Q3e OH
    4264 CMe NEt Q1m′ a bond Me a bond NH O NH Q3f OH
    4265 CMe NEt Q1m′ a bond Me a bond NH S a bond Q3a OH
    4266 CMe NEt Q1m′ a bond Me a bond NH S a bond Q3d OH
    4267 CMe NEt Q1m′ a bond Me a bond NH S a bond Q3e OH
    4268 CMe NEt Q1m′ a bond Me a bond NH S a bond Q3f OH
    4269 CMe NEt Q1m′ a bond Me a bond NH S NH Q3a OH
    4270 CMe NEt Q1m′ a bond Me a bond NH S NH Q3d OH
    4271 CMe NEt Q1m′ a bond Me a bond NH S NH Q3e OH
    4272 CMe NEt Q1m′ a bond Me a bond NH S NH Q3f OH
    4273 CMe NEt Q1n′ a bond Me a bond NH O a bond Q3a OH
    4274 CMe NEt Q1n′ a bond Me a bond NH O a bond Q3d OH
    4275 CMe NEt Q1n′ a bond Me a bond NH O a bond Q3e OH
    4276 CMe Net Q1n′ a bond Me a bond NH O a bond Q3f OH
    4277 CMe NEt Q1n′ a bond Me a bond NH O NH Q3a OH
    4278 CMe NEt Q1n′ a bond Me a bond NH O NH Q3d OH
    4279 CMe NEt Q1n′ a bond Me a bond NH O NH Q3e OH
    4280 CMe NEt Q1n′ a bond Me a bond NH O NH Q3f OH
    4281 CMe NEt Q1n′ a bond Me a bond NH S a bond Q3a OH
    4282 CMe NEt Q1n′ a bond Me a bond NH S a bond Q3d OH
    4283 CMe NEt Q1n′ a bond Me a bond NH S a bond Q3e OH
    4284 CMe NEt Q1n′ a bond Me a bond NH S a bond Q3f OH
    4285 CMe NEt Q1n′ a bond Me a bond NH S NH Q3a OH
    4286 CMe NEt Q1n′ a bond Me a bond NH S NH Q3d OH
    4287 CMe NEt Q1n′ a bond Me a bond NH S NH Q3e OH
    4288 CMe NEt Q1n′ a bond Me a bond NH S NH Q3f OH
    4289 CMe S Q1k′ a bond Me a bond NH O a bond Q3a OH
    4290 CMe S Q1k′ a bond Me a bond NH O a bond Q3d OH
    4291 CMe S Q1k′ a bond Me a bond NH O a bond Q3e OH
    4292 CMe S Q1k′ a bond Me a bond NH O a bond Q3f OH
    4293 CMe S Q1k′ a bond Me a bond NH O NH Q3a OH
    4294 CMe S Q1k′ a bond Me a bond NH O NH Q3d OH
    4295 CMe S Q1k′ a bond Me a bond NH O NH Q3e OH
    4296 CMe S Q1k′ a bond Me a bond NH O NH Q3f OH
    4297 CMe S Q1k′ a bond Me a bond NH S a bond Q3a OH
    4298 CMe S Q1k′ a bond Me a bond NH S a bond Q3d OH
    4299 CMe S Q1k′ a bond Me a bond NH S a bond Q3e OH
    4300 CMe S Q1k′ a bond Me a bond NH S a bond Q3f OH
    4301 CMe S Q1k′ a bond Me a bond NH S NH Q3a OH
    4302 CMe S Q1k′ a bond Me a bond NH S NH Q3d OH
    4303 CMe S Q1k′ a bond Me a bond NH S NH Q3e OH
    4304 CMe S Q1k′ a bond Me a bond NH S NH Q3f OH
    4305 CMe S Q1l′ a bond Me a bond NH O a bond Q3a OH
    4306 CMe S Q1l′ a bond Me a bond NH O a bond Q3d OH
    4307 CMe S Q1l′ a bond Me a bond NH O a bond Q3e OH
    4308 CMe S Q1l′ a bond Me a bond NH O a bond Q3f OH
    4309 CMe S Q1l′ a bond Me a bond NH O NH Q3a OH
    4310 CMe S Q1l′ a bond Me a bond NH O NH Q3d OH
    4311 CMe S Q1l′ a bond Me a bond NH O NH Q3e OH
    4312 CMe S Q1l′ a bond Me a bond NH O NH Q3f OH
    4313 CMe S Q1l′ a bond Me a bond NH S a bond Q3a OH
    4314 CMe S Q1l′ a bond Me a bond NH S a bond Q3d OH
    4315 CMe S Q1l′ a bond Me a bond NH S a bond Q3e OH
    4316 CMe S Q1l′ a bond Me a bond NH S a bond Q3f OH
    4317 CMe S Q1l′ a bond Me a bond NH S NH Q3a OH
    4318 CMe S Q1l′ a bond Me a bond NH S NH Q3d OH
    4319 CMe S Q1l′ a bond Me a bond NH S NH Q3e OH
    4320 CMe S Q1l′ a bond Me a bond NH S NH Q3f OH
    4321 CMe S Q1m′ a bond Me a bond NH O a bond Q3a OH
    4322 CMe S Q1m′ a bond Me a bond NH O a bond Q3d OH
    4323 CMe S Q1m′ a bond Me a bond NH O a bond Q3e OH
    4324 CMe S Q1m′ a bond Me a bond NH O a bond Q3f OH
    4325 CMe S Q1m′ a bond Me a bond NH O NH Q3a OH
    4326 CMe S Q1m′ a bond Me a bond NH O NH Q3d OH
    4327 CMe S Q1m′ a bond Me a bond NH O NH Q3e OH
    4328 CMe S Q1m′ a bond Me a bond NH O NH Q3f OH
    4329 CMe S Q1m′ a bond Me a bond NH S a bond Q3a OH
    4330 CMe S Q1m′ a bond Me a bond NH S a bond Q3d OH
    4331 CMe S Q1m′ a bond Me a bond NH S a bond Q3e OH
    4332 CMe S Q1m′ a bond Me a bond NH S a bond Q3f OH
    4333 CMe S Q1m′ a bond Me a bond NH S NH Q3a OH
    4334 CMe S Q1m′ a bond Me a bond NH S NH Q3d OH
    4335 CMe S Q1m′ a bond Me a bond NH S NH Q3e OH
    4336 CMe S Q1m′ a bond Me a bond NH S NH Q3f OH
    4337 CMe S Q1n′ a bond Me a bond NH O a bond Q3a OH
    4338 CMe S Q1n′ a bond Me a bond NH O a bond Q3d OH
    4339 CMe S Q1n′ a bond Me a bond NH O a bond Q3e OH
    4340 CMe S Q1n′ a bond Me a bond NH O a bond Q3f OH
    4341 CMe S Q1n′ a bond Me a bond NH O NH Q3a OH
    4342 CMe S Q1n′ a bond Me a bond NH O NH Q3d OH
    4343 CMe S Q1n′ a bond Me a bond NH O NH Q3e OH
    4344 CMe S Q1n′ a bond Me a bond NH O NH Q3f OH
    4345 CMe S Q1n′ a bond Me a bond NH S a bond Q3a OH
    4346 CMe S Q1n′ a bond Me a bond NH S a bond Q3d OH
    4347 CMe S Q1n′ a bond Me a bond NH S a bond Q3e OH
    4348 CMe S Q1n′ a bond Me a bond NH S a bond Q3f OH
    4349 CMe S Q1n′ a bond Me a bond NH S NH Q3a OH
    4350 CMe S Q1n′ a bond Me a bond NH S NH Q3d OH
    4351 CMe S Q1n′ a bond Me a bond NH S NH Q3e OH
    4352 CMe S Q1n′ a bond Me a bond NH S NH Q3f OH
    4353 CMe O Q1k′ a bond Me a bond NH O a bond Q3a OH
    4354 CMe O Q1k′ a bond Me a bond NH O a bond Q3d OH
    4355 CMe O Q1k′ a bond Me a bond NH O a bond Q3e OH
    4356 CMe O Q1k′ a bond Me a bond NH O a bond Q3f OH
    4357 CMe O Q1k′ a bond Me a bond NH O NH Q3a OH
    4358 CMe O Q1k′ a bond Me a bond NH O NH Q3d OH
    4359 CMe O Q1k′ a bond Me a bond NH O NH Q3e OH
    4360 CMe O Q1k′ a bond Me a bond NH O NH Q3f OH
    4361 CMe O Q1k′ a bond Me a bond NH S a bond Q3a OH
    4362 CMe O Q1k′ a bond Me a bond NH S a bond Q3d OH
    4363 CMe O Q1k′ a bond Me a bond NH S a bond Q3e OH
    4364 CMe O Q1k′ a bond Me a bond NH S a bond Q3f OH
    4365 CMe O Q1k′ a bond Me a bond NH S NH Q3a OH
    4366 CMe O Q1k′ a bond Me a bond NH S NH Q3d OH
    4367 CMe O Q1k′ a bond Me a bond NH S NH Q3e OH
    4368 CMe O Q1k′ a bond Me a bond NH S NH Q3f OH
    4369 CMe O Q1l′ a bond Me a bond NH O a bond Q3a OH
    4370 CMe O Q1l′ a bond Me a bond NH O a bond Q3d OH
    4371 CMe O Q1l′ a bond Me a bond NH O a bond Q3e OH
    4372 CMe O Q1l′ a bond Me a bond NH O a bond Q3f OH
    4373 CMe O Q1l′ a bond Me a bond NH O NH Q3a OH
    4374 CMe O Q1l′ a bond Me a bond NH O NH Q3d OH
    4375 CMe O Q1l′ a bond Me a bond NH O NH Q3e OH
    4376 CMe O Q1l′ a bond Me a bond NH O NH Q3f OH
    4377 CMe O Q1l′ a bond Me a bond NH S a bond Q3a OH
    4378 CMe O Q1l′ a bond Me a bond NH S a bond Q3d OH
    4379 CMe O Q1l′ a bond Me a bond NH S a bond Q3e OH
    4380 CMe O Q1l′ a bond Me a bond NH S a bond Q3f OH
    4381 CMe O Q1l′ a bond Me a bond NH S NH Q3a OH
    4382 CMe O Q1l′ a bond Me a bond NH S NH Q3d OH
    4383 CMe O Q1l′ a bond Me a bond NH S NH Q3e OH
    4384 CMe O Q1l′ a bond Me a bond NH S NH Q3f OH
    4385 CMe O Q1m′ a bond Me a bond NH O a bond Q3a OH
    4386 CMe O Q1m′ a bond Me a bond NH O a bond Q3d OH
    4387 CMe O Q1m′ a bond Me a bond NH O a bond Q3e OH
    4388 CMe O Q1m′ a bond Me a bond NH O a bond Q3f OH
    4389 CMe O Q1m′ a bond Me a bond NH O NH Q3a OH
    4390 CMe O Q1m′ a bond Me a bond NH O NH Q3d OH
    4391 CMe O Q1m′ a bond Me a bond NH O NH Q3e OH
    4392 CMe O Q1m′ a bond Me a bond NH O NH Q3f OH
    4393 CMe O Q1m′ a bond Me a bond NH S a bond Q3a OH
    4394 CMe O Q1m′ a bond Me a bond NH S a bond Q3d OH
    4395 CMe O Q1m′ a bond Me a bond NH S a bond Q3e OH
    4396 CMe O Q1m′ a bond Me a bond NH S a bond Q3f OH
    4397 CMe O Q1m′ a bond Me a bond NH S NH Q3a OH
    4398 CMe O Q1m′ a bond Me a bond NH S NH Q3d OH
    4399 CMe O Q1m′ a bond Me a bond NH S NH Q3e OH
    4400 CMe O Q1m′ a bond Me a bond NH S NH Q3f OH
    4401 CMe O Q1n′ a bond Me a bond NH O a bond Q3a OH
    4402 CMe O Q1n′ a bond Me a bond NH O a bond Q3d OH
    4403 CMe O Q1n′ a bond Me a bond NH O a bond Q3e OH
    4404 CMe O Q1n′ a bond Me a bond NH O a bond Q3f OH
    4405 CMe O Q1n′ a bond Me a bond NH O NH Q3a OH
    4406 CMe O Q1n′ a bond Me a bond NH O NH Q3d OH
    4407 CMe O Q1n′ a bond Me a bond NH O NH Q3e OH
    4408 CMe O Q1n′ a bond Me a bond NH O NH Q3f OH
    4409 CMe O Q1n′ a bond Me a bond NH S a bond Q3a OH
    4410 CMe O Q1n′ a bond Me a bond NH S a bond Q3d OH
    4411 CMe O Q1n′ a bond Me a bond NH S a bond Q3e OH
    4412 CMe O Q1n′ a bond Me a bond NH S a bond Q3f OH
    4413 CMe O Q1n′ a bond Me a bond NH S NH Q3a OH
    4414 CMe O Q1n′ a bond Me a bond NH S NH Q3d OH
    4415 CMe O Q1n′ a bond Me a bond NH S NH Q3e OH
    4416 CMe O Q1n′ a bond Me a bond NH S NH Q3f OH
    4417 N NMe Q1a a bond Me a bond NH O a bond Q3d OH
    4418 N NMe Q1a a bond Me a bond NH O a bond Q3e OH
    4419 N NMe Q1a a bond Me a bond NH O a bond Q3f OH
    4420 N NMe Q1a a bond Me a bond NH O NH Q3d OH
    4421 N NMe Q1a a bond Me a bond NH O NH Q3e OH
    4422 N NMe Q1a a bond Me a bond NH O NH Q3f OH
    4423 N NMe Q1a a bond Me a bond NH S a bond Q3d OH
    4424 N NMe Q1a a bond Me a bond NH S a bond Q3e OH
    4425 N NMe Q1a a bond Me a bond NH S a bond Q3f OH
    4426 N NMe Q1a a bond Me a bond NH S NH Q3d OH
    4427 N NMe Q1a a bond Me a bond NH S NH Q3e OH
    4428 N NMe Q1a a bond Me a bond NH S NH Q3f OH
    4429 N NMe Q1b a bond Me a bond NH O a bond Q3d OH
    4430 N NMe Q1b a bond Me a bond NH O a bond Q3e OH
    4431 N NMe Q1b a bond Me a bond NH O a bond Q3f OH
    4432 N NMe Q1b a bond Me a bond NH O NH Q3d OH
    4433 N NMe Q1b a bond Me a bond NH O NH Q3e OH
    4434 N NMe Q1b a bond Me a bond NH O NH Q3f OH
    4435 N NMe Q1b a bond Me a bond NH S a bond Q3d OH
    4436 N NMe Q1b a bond Me a bond NH S a bond Q3e OH
    4437 N NMe Q1b a bond Me a bond NH S a bond Q3f OH
    4438 N NMe Q1b a bond Me a bond NH S NH Q3d OH
    4439 N NMe Q1b a bond Me a bond NH S NH Q3e OH
    4440 N NMe Q1b a bond Me a bond NH S NH Q3f OH
    4441 N NMe Q1c a bond Me a bond NH O a bond Q3d OH
    4442 N NMe Q1c a bond Me a bond NH O a bond Q3e OH
    4443 N NMe Q1c a bond Me a bond NH O a bond Q3f OH
    4444 N NMe Q1c a bond Me a bond NH O NH Q3d OH
    4445 N NMe Q1c a bond Me a bond NH O NH Q3e OH
    4446 N NMe Q1c a bond Me a bond NH O NH Q3f OH
    4447 N NMe Q1c a bond Me a bond NH S a bond Q3d OH
    4448 N NMe Q1c a bond Me a bond NH S a bond Q3e OH
    4449 N NMe Q1c a bond Me a bond NH S a bond Q3f OH
    4450 N NMe Q1c a bond Me a bond NH S NH Q3d OH
    4451 N NMe Q1c a bond Me a bond NH S NH Q3e OH
    4452 N NMe Q1c a bond Me a bond NH S NH Q3f OH
    4453 N NEt Q1a a bond Me a bond NH O a bond Q3d OH
    4454 N NEt Q1a a bond Me a bond NH O a bond Q3e OH
    4455 N NEt Q1a a bond Me a bond NH O a bond Q3f OH
    4456 N NEt Q1a a bond Me a bond NH O NH Q3d OH
    4457 N NEt Q1a a bond Me a bond NH O NH Q3e OH
    4458 N NEt Q1a a bond Me a bond NH O NH Q3f OH
    4459 N NEt Q1a a bond Me a bond NH S a bond Q3d OH
    4460 N NEt Q1a a bond Me a bond NH S a bond Q3e OH
    4461 N NEt Q1a a bond Me a bond NH S a bond Q3f OH
    4462 N NEt Q1a a bond Me a bond NH S NH Q3d OH
    4463 N NEt Q1a a bond Me a bond NH S NH Q3e OH
    4464 N NEt Q1a a bond Me a bond NH S NH Q3f OH
    4465 N NEt Q1b a bond Me a bond NH O a bond Q3d OH
    4466 N NEt Q1b a bond Me a bond NH O a bond Q3e OH
    4467 N NEt Q1b a bond Me a bond NH O a bond Q3f OH
    4468 N NEt Q1b a bond Me a bond NH O NH Q3d OH
    4469 N NEt Q1b a bond Me a bond NH O NH Q3e OH
    4470 N NEt Q1b a bond Me a bond NH O NH Q3f OH
    4471 N NEt Q1b a bond Me a bond NH S a bond Q3d OH
    4472 N NEt Q1b a bond Me a bond NH S a bond Q3e OH
    4473 N NEt Q1b a bond Me a bond NH S a bond Q3f OH
    4474 N NEt Q1b a bond Me a bond NH S NH Q3d OH
    4475 N NEt Q1b a bond Me a bond NH S NH Q3e OH
    4476 N NEt Q1b a bond Me a bond NH S NH Q3f OH
    4477 N NEt Q1c a bond Me a bond NH O a bond Q3d OH
    4478 N NEt Q1c a bond Me a bond NH O a bond Q3e OH
    4479 N NEt Q1c a bond Me a bond NH O a bond Q3f OH
    4480 N NEt Q1c a bond Me a bond NH O NH Q3d OH
    4481 N NEt Q1c a bond Me a bond NH O NH Q3e OH
    4482 N NEt Q1c a bond Me a bond NH O NH Q3f OH
    4483 N NEt Q1c a bond Me a bond NH S a bond Q3d OH
    4484 N NEt Q1c a bond Me a bond NH S a bond Q3e OH
    4485 N NEt Q1c a bond Me a bond NH S a bond Q3f OH
    4486 N NEt Q1c a bond Me a bond NH S NH Q3d OH
    4487 N NEt Q1c a bond Me a bond NH S NH Q3e OH
    4488 N NEt Q1c a bond Me a bond NH S NH Q3f OH
    4489 N S Q1a a bond Me a bond NH O a bond Q3d OH
    4490 N S Q1a a bond Me a bond NH O a bond Q3e OH
    4491 N S Q1a a bond Me a bond NH O a bond Q3f OH
    4492 N S Q1a a bond Me a bond NH O NH Q3d OH
    4493 N S Q1a a bond Me a bond NH O NH Q3e OH
    4494 N S Q1a a bond Me a bond NH O NH Q3f OH
    4495 N S Q1a a bond Me a bond NH S a bond Q3d OH
    4496 N S Q1a a bond Me a bond NH S a bond Q3e OH
    4497 N S Q1a a bond Me a bond NH S a bond Q3f OH
    4498 N S Q1a a bond Me a bond NH S NH Q3d OH
    4499 N S Q1a a bond Me a bond NH S NH Q3e OH
    4500 N S Q1a a bond Me a bond NH S NH Q3f OH
    4501 N S Q1b a bond Me a bond NH O a bond Q3d OH
    4502 N S Q1b a bond Me a bond NH O a bond Q3e OH
    4503 N S Q1b a bond Me a bond NH O a bond Q3f OH
    4504 N S Q1b a bond Me a bond NH O NH Q3d OH
    4505 N S Q1b a bond Me a bond NH O NH Q3e OH
    4506 N S Q1b a bond Me a bond NH O NH Q3f OH
    4507 N S Q1b a bond Me a bond NH S a bond Q3d OH
    4508 N S Q1b a bond Me a bond NH S a bond Q3e OH
    4509 N S Q1b a bond Me a bond NH S a bond Q3f OH
    4510 N S Q1b a bond Me a bond NH S NH Q3d OH
    4511 N S Q1b a bond Me a bond NH S NH Q3e OH
    4512 N S Q1b a bond Me a bond NH S NH Q3f OH
    4513 N S Q1c a bond Me a bond NH O a bond Q3d OH
    4514 N S Q1c a bond Me a bond NH O a bond Q3e OH
    4515 N S Q1c a bond Me a bond NH O a bond Q3f OH
    4516 N S Q1c a bond Me a bond NH O NH Q3d OH
    4517 N S Q1c a bond Me a bond NH O NH Q3e OH
    4518 N S Q1c a bond Me a bond NH O NH Q3f OH
    4519 N S Q1c a bond Me a bond NH S a bond Q3d OH
    4520 N S Q1c a bond Me a bond NH S a bond Q3e OH
    4521 N S Q1c a bond Me a bond NH S a bond Q3f OH
    4522 N S Q1c a bond Me a bond NH S NH Q3d OH
    4523 N S Q1c a bond Me a bond NH S NH Q3e OH
    4524 N S Q1c a bond Me a bond NH S NH Q3f OH
    4525 N O Q1a a bond Me a bond NH O a bond Q3d OH
    4526 N O Q1a a bond Me a bond NH O a bond Q3e OH
    4527 N O Q1a a bond Me a bond NH O a bond Q3f OH
    4528 N O Q1a a bond Me a bond NH O NH Q3d OH
    4529 N O Q1a a bond Me a bond NH O NH Q3e OH
    4530 N O Q1a a bond Me a bond NH O NH Q3f OH
    4531 N O Q1a a bond Me a bond NH S a bond Q3d OH
    4532 N O Q1a a bond Me a bond NH S a bond Q3e OH
    4533 N O Q1a a bond Me a bond NH S a bond Q3f OH
    4534 N O Q1a a bond Me a bond NH S NH Q3d OH
    4535 N O Q1a a bond Me a bond NH S NH Q3e OH
    4536 N O Q1a a bond Me a bond NH S NH Q3f OH
    4537 N O Q1b a bond Me a bond NH O a bond Q3d OH
    4538 N O Q1b a bond Me a bond NH O a bond Q3e OH
    4539 N O Q1b a bond Me a bond NH O a bond Q3f OH
    4540 N O Q1b a bond Me a bond NH O NH Q3d OH
    4541 N O Q1b a bond Me a bond NH O NH Q3e OH
    4542 N O Q1b a bond Me a bond NH O NH Q3f OH
    4543 N O Q1b a bond Me a bond NH S a bond Q3d OH
    4544 N O Q1b a bond Me a bond NH S a bond Q3e OH
    4545 N O Q1b a bond Me a bond NH S a bond Q3f OH
    4546 N O Q1b a bond Me a bond NH S NH Q3d OH
    4547 N O Q1b a bond Me a bond NH S NH Q3e OH
    4548 N O Q1b a bond Me a bond NH S NH Q3f OH
    4549 N O Q1c a bond Me a bond NH O a bond Q3d OH
    4550 N O Q1c a bond Me a bond NH O a bond Q3e OH
    4551 N O Q1c a bond Me a bond NH O a bond Q3f OH
    4552 N O Q1c a bond Me a bond NH O NH Q3d OH
    4553 N O Q1c a bond Me a bond NH O NH Q3e OH
    4554 N O Q1c a bond Me a bond NH O NH Q3f OH
    4555 N O Q1c a bond Me a bond NH S a bond Q3d OH
    4556 N O Q1c a bond Me a bond NH S a bond Q3e OH
    4557 N O Q1c a bond Me a bond NH S a bond Q3f OH
    4558 N O Q1c a bond Me a bond NH S NH Q3d OH
    4559 N O Q1c a bond Me a bond NH S NH Q3e OH
    4560 N O Q1c a bond Me a bond NH S NH Q3f OH
    4561 CH NMe Q1a a bond Me a bond NH O a bond Q3d OH
    4562 CH NMe Q1a a bond Me a bond NH O a bond Q3e OH
    4563 CH NMe Q1a a bond Me a bond NH O a bond Q3f OH
    4564 CH NMe Q1a a bond Me a bond NH O NH Q3d OH
    4565 CH NMe Q1a a bond Me a bond NH O NH Q3e OH
    4566 CH NMe Q1a a bond Me a bond NH O NH Q3f OH
    4567 CH NMe Q1a a bond Me a bond NH S a bond Q3d OH
    4568 CH NMe Q1a a bond Me a bond NH S a bond Q3e OH
    4569 CH NMe Q1a a bond Me a bond NH S a bond Q3f OH
    4570 CH NMe Q1a a bond Me a bond NH S NH Q3d OH
    4571 CH NMe Q1a a bond Me a bond NH S NH Q3e OH
    4572 CH NMe Q1a a bond Me a bond NH S NH Q3f OH
    4573 CH NMe Q1b a bond Me a bond NH O a bond Q3d OH
    4574 CH NMe Q1b a bond Me a bond NH O a bond Q3e OH
    4575 CH NMe Q1b a bond Me a bond NH O a bond Q3f OH
    4576 CH NMe Q1b a bond Me a bond NH O NH Q3d OH
    4577 CH NMe Q1b a bond Me a bond NH O NH Q3e OH
    4578 CH NMe Q1b a bond Me a bond NH O NH Q3f OH
    4579 CH NMe Q1b a bond Me a bond NH S a bond Q3d OH
    4580 CH NMe Q1b a bond Me a bond NH S a bond Q3e OH
    4581 CH NMe Q1b a bond Me a bond NH S a bond Q3f OH
    4582 CH NMe Q1b a bond Me a bond NH S NH Q3d OH
    4583 CH NMe Q1b a bond Me a bond NH S NH Q3e OH
    4584 CH NMe Q1b a bond Me a bond NH S NH Q3f OH
    4585 CH NMe Q1c a bond Me a bond NH O a bond Q3d OH
    4586 CH NMe Q1c a bond Me a bond NH O a bond Q3e OH
    4587 CH NMe Q1c a bond Me a bond NH O a bond Q3f OH
    4588 CH NMe Q1c a bond Me a bond NH O NH Q3d OH
    4589 CH NMe Q1c a bond Me a bond NH O NH Q3e OH
    4590 CH NMe Q1c a bond Me a bond NH O NH Q3f OH
    4591 CH NMe Q1c a bond Me a bond NH S a bond Q3d OH
    4592 CH NMe Q1c a bond Me a bond NH S a bond Q3e OH
    4593 CH NMe Q1c a bond Me a bond NH S a bond Q3f OH
    4594 CH NMe Q1c a bond Me a bond NH S NH Q3d OH
    4595 CH NMe Q1c a bond Me a bond NH S NH Q3e OH
    4596 CH NMe Q1c a bond Me a bond NH S NH Q3f OH
    4597 CH NEt Q1a a bond Me a bond NH O a bond Q3d OH
    4598 CH NEt Q1a a bond Me a bond NH O a bond Q3e OH
    4599 CH NEt Q1a a bond Me a bond NH O a bond Q3f OH
    4600 CH NEt Q1a a bond Me a bond NH O NH Q3d OH
    4601 CH NEt Q1a a bond Me a bond NH O NH Q3e OH
    4602 CH NEt Q1a a bond Me a bond NH O NH Q3f OH
    4603 CH NEt Q1a a bond Me a bond NH S a bond Q3d OH
    4604 CH NEt Q1a a bond Me a bond NH S a bond Q3e OH
    4605 CH NEt Q1a a bond Me a bond NH S a bond Q3f OH
    4606 CH NEt Q1a a bond Me a bond NH S NH Q3d OH
    4607 CH NEt Q1a a bond Me a bond NH S NH Q3e OH
    4608 CH NEt Q1a a bond Me a bond NH S NH Q3f OH
    4609 CH NEt Q1b a bond Me a bond NH O a bond Q3d OH
    4610 CH NEt Q1b a bond Me a bond NH O a bond Q3e OH
    4611 CH NEt Q1b a bond Me a bond NH O a bond Q3f OH
    4612 CH NEt Q1b a bond Me a bond NH O NH Q3d OH
    4613 CH NEt Q1b a bond Me a bond NH O NH Q3e OH
    4614 CH NEt Q1b a bond Me a bond NH O NH Q3f OH
    4615 CH NEt Q1b a bond Me a bond NH S a bond Q3d OH
    4616 CH NEt Q1b a bond Me a bond NH S a bond Q3e OH
    4617 CH NEt Q1b a bond Me a bond NH S a bond Q3f OH
    4618 CH NEt Q1b a bond Me a bond NH S NH Q3d OH
    4619 CH NEt Q1b a bond Me a bond NH S NH Q3e OH
    4620 CH NEt Q1b a bond Me a bond NH S NH Q3f OH
    4621 CH NEt Q1c a bond Me a bond NH O a bond Q3d OH
    4622 CH NEt Q1c a bond Me a bond NH O a bond Q3e OH
    4623 CH NEt Q1c a bond Me a bond NH O a bond Q3f OH
    4624 CH NEt Q1c a bond Me a bond NH O NH Q3d OH
    4625 CH NEt Q1c a bond Me a bond NH O NH Q3e OH
    4626 CH NEt Q1c a bond Me a bond NH O NH Q3f OH
    4627 CH NEt Q1c a bond Me a bond NH S a bond Q3d OH
    4628 CH NEt Q1c a bond Me a bond NH S a bond Q3e OH
    4629 CH NEt Q1c a bond Me a bond NH S a bond Q3f OH
    4630 CH NEt Q1c a bond Me a bond NH S NH Q3d OH
    4631 CH NEt Q1c a bond Me a bond NH S NH Q3e OH
    4632 CH NEt Q1c a bond Me a bond NH S NH Q3f OH
    4633 CH S Q1a a bond Me a bond NH O a bond Q3d OH
    4634 CH S Q1a a bond Me a bond NH O a bond Q3e OH
    4635 CH S Q1a a bond Me a bond NH O a bond Q3f OH
    4636 CH S Q1a a bond Me a bond NH O NH Q3d OH
    4637 CH S Q1a a bond Me a bond NH O NH Q3e OH
    4638 CH S Q1a a bond Me a bond NH O NH Q3f OH
    4639 CH S Q1a a bond Me a bond NH S a bond Q3d OH
    4640 CH S Q1a a bond Me a bond NH S a bond Q3e OH
    4641 CH S Q1a a bond Me a bond NH S a bond Q3f OH
    4642 CH S Q1a a bond Me a bond NH S NH Q3d OH
    4643 CH S Q1a a bond Me a bond NH S NH Q3e OH
    4644 CH S Q1a a bond Me a bond NH S NH Q3f OH
    4645 CH S Q1b a bond Me a bond NH O a bond Q3d OH
    4646 CH S Q1b a bond Me a bond NH O a bond Q3e OH
    4647 CH S Q1b a bond Me a bond NH O a bond Q3f OH
    4648 CH S Q1b a bond Me a bond NH O NH Q3d OH
    4649 CH S Q1b a bond Me a bond NH O NH Q3e OH
    4650 CH S Q1b a bond Me a bond NH O NH Q3f OH
    4651 CH S Q1b a bond Me a bond NH S a bond Q3d OH
    4652 CH S Q1b a bond Me a bond NH S a bond Q3e OH
    4653 CH S Q1b a bond Me a bond NH S a bond Q3f OH
    4654 CH S Q1b a bond Me a bond NH S NH Q3d OH
    4655 CH S Q1b a bond Me a bond NH S NH Q3e OH
    4656 CH S Q1b a bond Me a bond NH S NH Q3f OH
    4657 CH S Q1c a bond Me a bond NH O a bond Q3d OH
    4658 CH S Q1c a bond Me a bond NH O a bond Q3e OH
    4659 CH S Q1c a bond Me a bond NH O a bond Q3f OH
    4660 CH S Q1c a bond Me a bond NH O NH Q3d OH
    4661 CH S Q1c a bond Me a bond NH O NH Q3e OH
    4662 CH S Q1c a bond Me a bond NH O NH Q3f OH
    4663 CH S Q1c a bond Me a bond NH S a bond Q3d OH
    4664 CH S Q1c a bond Me a bond NH S a bond Q3e OH
    4665 CH S Q1c a bond Me a bond NH S a bond Q3f OH
    4666 CH S Q1c a bond Me a bond NH S NH Q3d OH
    4667 CH S Q1c a bond Me a bond NH S NH Q3e OH
    4668 CH S Q1c a bond Me a bond NH S NH Q3f OH
    4669 CH O Q1a a bond Me a bond NH O a bond Q3d OH
    4670 CH O Q1a a bond Me a bond NH O a bond Q3e OH
    4671 CH O Q1a a bond Me a bond NH O a bond Q3f OH
    4672 CH O Q1a a bond Me a bond NH O NH Q3d OH
    4673 CH O Q1a a bond Me a bond NH O NH Q3e OH
    4674 CH O Q1a a bond Me a bond NH O NH Q3f OH
    4675 CH O Q1a a bond Me a bond NH S a bond Q3d OH
    4676 CH O Q1a a bond Me a bond NH S a bond Q3e OH
    4677 CH O Q1a a bond Me a bond NH S a bond Q3f OH
    4678 CH O Q1a a bond Me a bond NH S NH Q3d OH
    4679 CH O Q1a a bond Me a bond NH S NH Q3e OH
    4680 CH O Q1a a bond Me a bond NH S NH Q3f OH
    4681 CH O Q1b a bond Me a bond NH O a bond Q3d OH
    4682 CH O Q1b a bond Me a bond NH O a bond Q3e OH
    4683 CH O Q1b a bond Me a bond NH O a bond Q3f OH
    4684 CH O Q1b a bond Me a bond NH O NH Q3d OH
    4685 CH O Q1b a bond Me a bond NH O NH Q3e OH
    4686 CH O Q1b a bond Me a bond NH O NH Q3f OH
    4687 CH O Q1b a bond Me a bond NH S a bond Q3d OH
    4688 CH O Q1b a bond Me a bond NH S a bond Q3e OH
    4689 CH O Q1b a bond Me a bond NH S a bond Q3f OH
    4690 CH O Q1b a bond Me a bond NH S NH Q3d OH
    4691 CH O Q1b a bond Me a bond NH S NH Q3e OH
    4692 CH O Q1b a bond Me a bond NH S NH Q3f OH
    4693 CH O Q1c a bond Me a bond NH O a bond Q3d OH
    4694 CH O Q1c a bond Me a bond NH O a bond Q3e OH
    4695 CH O Q1c a bond Me a bond NH O a bond Q3f OH
    4696 CH O Q1c a bond Me a bond NH O NH Q3d OH
    4697 CH O Q1c a bond Me a bond NH O NH Q3e OH
    4698 CH O Q1c a bond Me a bond NH O NH Q3f OH
    4699 CH O Q1c a bond Me a bond NH S a bond Q3d OH
    4700 CH O Q1c a bond Me a bond NH S a bond Q3e OH
    4701 CH O Q1c a bond Me a bond NH S a bond Q3f OH
    4702 CH O Q1c a bond Me a bond NH S NH Q3d OH
    4703 CH O Q1c a bond Me a bond NH S NH Q3e OH
    4704 CH O Q1c a bond Me a bond NH S NH Q3f OH
    4705 CMe NMe Q1a a bond Me a bond NH O a bond Q3d OH
    4706 CMe NMe Q1a a bond Me a bond NH O a bond Q3e OH
    4707 CMe NMe Q1a a bond Me a bond NH O a bond Q3f OH
    4708 CMe NMe Q1a a bond Me a bond NH O NH Q3d OH
    4709 CMe NMe Q1a a bond Me a bond NH O NH Q3e OH
    4710 CMe NMe Q1a a bond Me a bond NH O NH Q3f OH
    4711 CMe NMe Q1a a bond Me a bond NH S a bond Q3d OH
    4712 CMe NMe Q1a a bond Me a bond NH S a bond Q3e OH
    4713 CMe NMe Q1a a bond Me a bond NH S a bond Q3f OH
    4714 CMe NMe Q1a a bond Me a bond NH S NH Q3d OH
    4715 CMe NMe Q1a a bond Me a bond NH S NH Q3e OH
    4716 CMe NMe Q1a a bond Me a bond NH S NH Q3f OH
    4717 CMe NMe Q1b a bond Me a bond NH O a bond Q3d OH
    4718 CMe NMe Q1b a bond Me a bond NH O a bond Q3e OH
    4719 CMe NMe Q1b a bond Me a bond NH O a bond Q3f OH
    4720 CMe NMe Q1b a bond Me a bond NH O NH Q3d OH
    4721 CMe NMe Q1b a bond Me a bond NH O NH Q3e OH
    4722 CMe NMe Q1b a bond Me a bond NH O NH Q3f OH
    4723 CMe NMe Q1b a bond Me a bond NH S a bond Q3d OH
    4724 CMe NMe Q1b a bond Me a bond NH S a bond Q3e OH
    4725 CMe NMe Q1b a bond Me a bond NH S a bond Q3f OH
    4726 CMe NMe Q1b a bond Me a bond NH S NH Q3d OH
    4727 CMe NMe Q1b a bond Me a bond NH S NH Q3e OH
    4728 CMe NMe Q1b a bond Me a bond NH S NH Q3f OH
    4729 CMe NMe Q1c a bond Me a bond NH O a bond Q3d OH
    4730 CMe NMe Q1c a bond Me a bond NH O a bond Q3e OH
    4731 CMe NMe Q1c a bond Me a bond NH O a bond Q3f OH
    4732 CMe NMe Q1c a bond Me a bond NH O NH Q3d OH
    4733 CMe NMe Q1c a bond Me a bond NH O NH Q3e OH
    4734 CMe NMe Q1c a bond Me a bond NH O NH Q3f OH
    4735 CMe NMe Q1c a bond Me a bond NH S a bond Q3d OH
    4736 CMe NMe Q1c a bond Me a bond NH S a bond Q3e OH
    4737 CMe NMe Q1c a bond Me a bond NH S a bond Q3f OH
    4738 CMe NMe Q1c a bond Me a bond NH S NH Q3d OH
    4739 CMe NMe Q1c a bond Me a bond NH S NH Q3e OH
    4740 CMe NMe Q1c a bond Me a bond NH S NH Q3f OH
    4741 CMe NEt Q1a a bond Me a bond NH O a bond Q3d OH
    4742 CMe NEt Q1a a bond Me a bond NH O a bond Q3e OH
    4743 CMe NEt Q1a a bond Me a bond NH O a bond Q3f OH
    4744 CMe NEt Q1a a bond Me a bond NH O NH Q3d OH
    4745 CMe NEt Q1a a bond Me a bond NH O NH Q3e OH
    4746 CMe NEt Q1a a bond Me a bond NH O NH Q3f OH
    4747 CMe NEt Q1a a bond Me a bond NH S a bond Q3d OH
    4748 CMe NEt Q1a a bond Me a bond NH S a bond Q3e OH
    4749 CMe NEt Q1a a bond Me a bond NH S a bond Q3f OH
    4750 CMe NEt Q1a a bond Me a bond NH S NH Q3d OH
    4751 CMe NEt Q1a a bond Me a bond NH S NH Q3e OH
    4752 CMe NEt Q1a a bond Me a bond NH S NH Q3f OH
    4753 CMe NEt Q1b a bond Me a bond NH O a bond Q3d OH
    4754 CMe NEt Q1b a bond Me a bond NH O a bond Q3e OH
    4755 CMe NEt Q1b a bond Me a bond NH O a bond Q3f OH
    4756 CMe NEt Q1b a bond Me a bond NH O NH Q3d OH
    4757 CMe NEt Q1b a bond Me a bond NH O NH Q3e OH
    4758 CMe NEt Q1b a bond Me a bond NH O NH Q3f OH
    4759 CMe NEt Q1b a bond Me a bond NH S a bond Q3d OH
    4760 CMe NEt Q1b a bond Me a bond NH S a bond Q3e OH
    4761 CMe NEt Q1b a bond Me a bond NH S a bond Q3f OH
    4762 CMe NEt Q1b a bond Me a bond NH S NH Q3d OH
    4763 CMe NEt Q1b a bond Me a bond NH S NH Q3e OH
    4764 CMe NEt Q1b a bond Me a bond NH S NH Q3f OH
    4765 CMe NEt Q1c a bond Me a bond NH O a bond Q3d OH
    4766 CMe NEt Q1c a bond Me a bond NH O a bond Q3e OH
    4767 CMe NEt Q1c a bond Me a bond NH O a bond Q3f OH
    4768 CMe NEt Q1c a bond Me a bond NH O NH Q3d OH
    4769 CMe NEt Q1c a bond Me a bond NH O NH Q3e OH
    4770 CMe NEt Q1c a bond Me a bond NH O NH Q3f OH
    4771 CMe NEt Q1c a bond Me a bond NH S a bond Q3d OH
    4772 CMe NEt Q1c a bond Me a bond NH S a bond Q3e OH
    4773 CMe NEt Q1c a bond Me a bond NH S a bond Q3f OH
    4774 CMe NEt Q1c a bond Me a bond NH S NH Q3d OH
    4775 CMe NEt Q1c a bond Me a bond NH S NH Q3e OH
    4776 CMe NEt Q1c a bond Me a bond NH S NH Q3f OH
    4777 CMe S Q1a a bond Me a bond NH O a bond Q3d OH
    4778 CMe S Q1a a bond Me a bond NH O a bond Q3e OH
    4779 CMe S Q1a a bond Me a bond NH O a bond Q3f OH
    4780 CMe S Q1a a bond Me a bond NH O NH Q3d OH
    4781 CMe S Q1a a bond Me a bond NH O NH Q3e OH
    4782 CMe S Q1a a bond Me a bond NH O NH Q3f OH
    4783 CMe S Q1a a bond Me a bond NH S a bond Q3d OH
    4784 CMe S Q1a a bond Me a bond NH S a bond Q3e OH
    4785 CMe S Q1a a bond Me a bond NH S a bond Q3f OH
    4786 CMe S Q1a a bond Me a bond NH S NH Q3d OH
    4787 CMe S Q1a a bond Me a bond NH S NH Q3e OH
    4788 CMe S Q1a a bond Me a bond NH S NH Q3f OH
    4789 CMe S Q1b a bond Me a bond NH O a bond Q3d OH
    4790 CMe S Q1b a bond Me a bond NH O a bond Q3e OH
    4791 CMe S Q1b a bond Me a bond NH O a bond Q3f OH
    4792 CMe S Q1b a bond Me a bond NH O NH Q3d OH
    4793 CMe S Q1b a bond Me a bond NH O NH Q3e OH
    4794 CMe S Q1b a bond Me a bond NH O NH Q3f OH
    4795 CMe S Q1b a bond Me a bond NH S a bond Q3d OH
    4796 CMe S Q1b a bond Me a bond NH S a bond Q3e OH
    4797 CMe S Q1b a bond Me a bond NH S a bond Q3f OH
    4798 CMe S Q1b a bond Me a bond NH S NH Q3d OH
    4799 CMe S Q1b a bond Me a bond NH S NH Q3e OH
    4800 CMe S Q1b a bond Me a bond NH S NH Q3f OH
    4801 CMe S Q1c a bond Me a bond NH O a bond Q3d OH
    4802 CMe S Q1c a bond Me a bond NH O a bond Q3e OH
    4803 CMe S Q1c a bond Me a bond NH O a bond Q3f OH
    4804 CMe S Q1c a bond Me a bond NH O NH Q3d OH
    4805 CMe S Q1c a bond Me a bond NH O NH Q3e OH
    4806 CMe S Q1c a bond Me a bond NH O NH Q3f OH
    4807 CMe S Q1c a bond Me a bond NH S a bond Q3d OH
    4808 CMe S Q1c a bond Me a bond NH S a bond Q3e OH
    4809 CMe S Q1c a bond Me a bond NH S a bond Q3f OH
    4810 CMe S Q1c a bond Me a bond NH S NH Q3d OH
    4811 CMe S Q1c a bond Me a bond NH S NH Q3e OH
    4812 CMe S Q1c a bond Me a bond NH S NH Q3f OH
    4813 CMe O Q1a a bond Me a bond NH O a bond Q3d OH
    4814 CMe O Q1a a bond Me a bond NH O a bond Q3e OH
    4815 CMe O Q1a a bond Me a bond NH O a bond Q3f OH
    4816 CMe O Q1a a bond Me a bond NH O NH Q3d OH
    4817 CMe O Q1a a bond Me a bond NH O NH Q3e OH
    4818 CMe O Q1a a bond Me a bond NH O NH Q3f OH
    4819 CMe O Q1a a bond Me a bond NH S a bond Q3d OH
    4820 CMe O Q1a a bond Me a bond NH S a bond Q3e OH
    4821 CMe O Q1a a bond Me a bond NH S a bond Q3f OH
    4822 CMe O Q1a a bond Me a bond NH S NH Q3d OH
    4823 CMe O Q1a a bond Me a bond NH S NH Q3e OH
    4824 CMe O Q1a a bond Me a bond NH S NH Q3f OH
    4825 CMe O Q1b a bond Me a bond NH O a bond Q3d OH
    4826 CMe O Q1b a bond Me a bond NH O a bond Q3e OH
    4827 CMe O Q1b a bond Me a bond NH O a bond Q3f OH
    4828 CMe O Q1b a bond Me a bond NH O NH Q3d OH
    4829 CMe O Q1b a bond Me a bond NH O NH Q3e OH
    4830 CMe O Q1b a bond Me a bond NH O NH Q3f OH
    4831 CMe O Q1b a bond Me a bond NH S a bond Q3d OH
    4832 CMe O Q1b a bond Me a bond NH S a bond Q3e OH
    4833 CMe O Q1b a bond Me a bond NH S a bond Q3f OH
    4834 CMe O Q1b a bond Me a bond NH S NH Q3d OH
    4835 CMe O Q1b a bond Me a bond NH S NH Q3e OH
    4836 CMe O Q1b a bond Me a bond NH S NH Q3f OH
    4837 CMe O Q1c a bond Me a bond NH O a bond Q3d OH
    4838 CMe O Q1c a bond Me a bond NH O a bond Q3e OH
    4839 CMe O Q1c a bond Me a bond NH O a bond Q3f OH
    4840 CMe O Q1c a bond Me a bond NH O NH Q3d OH
    4841 CMe O Q1c a bond Me a bond NH O NH Q3e OH
    4842 CMe O Q1c a bond Me a bond NH O NH Q3f OH
    4843 CMe O Q1c a bond Me a bond NH S a bond Q3d OH
    4844 CMe O Q1c a bond Me a bond NH S a bond Q3e OH
    4845 CMe O Q1c a bond Me a bond NH S a bond Q3f OH
    4846 CMe O Q1c a bond Me a bond NH S NH Q3d OH
    4847 CMe O Q1c a bond Me a bond NH S NH Q3e OH
    4848 CMe O Q1c a bond Me a bond NH S NH Q3f OH
    4849 N NMe Q1a a bond Me a bond NH S NH Q3g OH
    4850 N NMe Q1a a bond Me a bond NH S NH Q3h OH
    4851 N NMe Q1b a bond Me a bond NH S NH Q3g OH
    4852 N NMe Q1b a bond Me a bond NH S NH Q3h OH
    4853 N NMe Q1c a bond Me a bond NH S NH Q3g OH
    4854 N NMe Q1c a bond Me a bond NH S NH Q3h OH
    4855 N NEt Q1a a bond Me a bond NH S NH Q3g OH
    4856 N NEt Q1a a bond Me a bond NH S NH Q3h OH
    4857 N NEt Q1b a bond Me a bond NH S NH Q3g OH
    4858 N NEt Q1b a bond Me a bond NH S NH Q3h OH
    4859 N NEt Q1c a bond Me a bond NH S NH Q3g OH
    4860 N NEt Q1c a bond Me a bond NH S NH Q3h OH
    4861 N S Q1a a bond Me a bond NH S NH Q3g OH
    4862 N S Q1a a bond Me a bond NH S NH Q3h OH
    4863 N S Q1b a bond Me a bond NH S NH Q3g OH
    4864 N S Q1b a bond Me a bond NH S NH Q3h OH
    4865 N S Q1c a bond Me a bond NH S NH Q3g OH
    4866 N S Q1c a bond Me a bond NH S NH Q3h OH
    4867 N O Q1a a bond Me a bond NH S NH Q3g OH
    4868 N O Q1a a bond Me a bond NH S NH Q3h OH
    4869 N O Q1b a bond Me a bond NH S NH Q3g OH
    4870 N O Q1b a bond Me a bond NH S NH Q3h OH
    4871 N O Q1c a bond Me a bond NH S NH Q3g OH
    4872 N O Q1c a bond Me a bond NH S NH Q3h OH
    4873 CH NMe Q1a a bond Me a bond NH S NH Q3g OH
    4874 CH NMe Q1a a bond Me a bond NH S NH Q3h OH
    4875 CH NMe Q1b a bond Me a bond NH S NH Q3g OH
    4876 CH NMe Q1b a bond Me a bond NH S NH Q3h OH
    4877 CH NMe Q1c a bond Me a bond NH S NH Q3g OH
    4878 CH NMe Q1c a bond Me a bond NH S NH Q3h OH
    4879 CH NEt Q1a a bond Me a bond NH S NH Q3g OH
    4880 CH NEt Q1a a bond Me a bond NH S NH Q3h OH
    4881 CH NEt Q1b a bond Me a bond NH S NH Q3g OH
    4882 CH NEt Q1b a bond Me a bond NH S NH Q3h OH
    4883 CH NEt Q1c a bond Me a bond NH S NH Q3g OH
    4884 CH NEt Q1c a bond Me a bond NH S NH Q3h OH
    4885 CH S Q1a a bond Me a bond NH S NH Q3g OH
    4886 CH S Q1a a bond Me a bond NH S NH Q3h OH
    4887 CH S Q1b a bond Me a bond NH S NH Q3g OH
    4888 CH S Q1b a bond Me a bond NH S NH Q3h OH
    4889 CH S Q1c a bond Me a bond NH S NH Q3g OH
    4890 CH S Q1c a bond Me a bond NH S NH Q3h OH
    4891 CH O Q1a a bond Me a bond NH S NH Q3g OH
    4892 CH O Q1a a bond Me a bond NH S NH Q3h OH
    4893 CH O Q1b a bond Me a bond NH S NH Q3g OH
    4894 CH O Q1b a bond Me a bond NH S NH Q3h OH
    4895 CH O Q1c a bond Me a bond NH S NH Q3g OH
    4896 CH O Q1c a bond Me a bond NH S NH Q3h OH
    4897 CMe NMe Q1a a bond Me a bond NH S NH Q3g OH
    4898 CMe NMe Q1a a bond Me a bond NH S NH Q3h OH
    4899 CMe NMe Q1b a bond Me a bond NH S NH Q3g OH
    4900 CMe NMe Q1b a bond Me a bond NH S NH Q3h OH
    4901 CMe NMe Q1c a bond Me a bond NH S NH Q3g OH
    4902 CMe NMe Q1c a bond Me a bond NH S NH Q3h OH
    4903 CMe NEt Q1a a bond Me a bond NH S NH Q3g OH
    4904 CMe NEt Q1a a bond Me a bond NH S NH Q3h OH
    4905 CMe NEt Q1b a bond Me a bond NH S NH Q3g OH
    4906 CMe NEt Q1b a bond Me a bond NH S NH Q3h OH
    4907 CMe NEt Q1c a bond Me a bond NH S NH Q3g OH
    4908 CMe NEt Q1c a bond Me a bond NH S NH Q3h OH
    4909 CMe S Q1a a bond Me a bond NH S NH Q3g OH
    4910 CMe S Q1a a bond Me a bond NH S NH Q3h OH
    4911 CMe S Q1b a bond Me a bond NH S NH Q3g OH
    4912 CMe S Q1b a bond Me a bond NH S NH Q3h OH
    4913 CMe S Q1c a bond Me a bond NH S NH Q3g OH
    4914 CMe S Q1c a bond Me a bond NH S NH Q3h OH
    4915 CMe O Q1a a bond Me a bond NH S NH Q3g OH
    4916 CMe O Q1a a bond Me a bond NH S NH Q3h OH
    4917 CMe O Q1b a bond Me a bond NH S NH Q3g OH
    4918 CMe O Q1b a bond Me a bond NH S NH Q3h OH
    4919 CMe O Q1c a bond Me a bond NH S NH Q3g OH
    4920 CMe O Q1c a bond Me a bond NH S NH Q3h OH
    4921 N NMe Q1a a bond Me a bond NH O a bond Q3g OH
    4922 N NMe Q1a a bond Me a bond NH O a bond Q3h OH
    4923 N NMe Q1b a bond Me a bond NH O a bond Q3g OH
    4924 N NMe Q1b a bond Me a bond NH O a bond Q3h OH
    4925 N NMe Q1c a bond Me a bond NH O a bond Q3g OH
    4926 N NMe Q1c a bond Me a bond NH O a bond Q3h OH
    4927 N NEt Q1a a bond Me a bond NH O a bond Q3g OH
    4928 N NEt Q1a a bond Me a bond NH O a bond Q3h OH
    4929 N NEt Q1b a bond Me a bond NH O a bond Q3g OH
    4930 N NEt Q1b a bond Me a bond NH O a bond Q3h OH
    4931 N NEt Q1c a bond Me a bond NH O a bond Q3g OH
    4932 N NEt Q1c a bond Me a bond NH O a bond Q3h OH
    4933 N S Q1a a bond Me a bond NH O a bond Q3g OH
    4934 N S Q1a a bond Me a bond NH O a bond Q3h OH
    4935 N S Q1b a bond Me a bond NH O a bond Q3g OH
    4936 N S Q1b a bond Me a bond NH O a bond Q3h OH
    4937 N S Q1c a bond Me a bond NH O a bond Q3g OH
    4938 N S Q1c a bond Me a bond NH O a bond Q3h OH
    4939 N O Q1a a bond Me a bond NH O a bond Q3g OH
    4940 N O Q1a a bond Me a bond NH O a bond Q3h OH
    4941 N O Q1b a bond Me a bond NH O a bond Q3g OH
    4942 N O Q1b a bond Me a bond NH O a bond Q3h OH
    4943 N O Q1c a bond Me a bond NH O a bond Q3g OH
    4944 N O Q1c a bond Me a bond NH O a bond Q3h OH
    4945 CH NMe Q1a a bond Me a bond NH O a bond Q3g OH
    4946 CH NMe Q1a a bond Me a bond NH O a bond Q3h OH
    4947 CH NMe Q1b a bond Me a bond NH O a bond Q3g OH
    4948 CH NMe Q1b a bond Me a bond NH O a bond Q3h OH
    4949 CH NMe Q1c a bond Me a bond NH O a bond Q3g OH
    4950 CH NMe Q1c a bond Me a bond NH O a bond Q3h OH
    4951 CH NEt Q1a a bond Me a bond NH O a bond Q3g OH
    4952 CH NEt Q1a a bond Me a bond NH O a bond Q3h OH
    4953 CH NEt Q1b a bond Me a bond NH O a bond Q3g OH
    4954 CH NEt Q1b a bond Me a bond NH O a bond Q3h OH
    4955 CH NEt Q1c a bond Me a bond NH O a bond Q3g OH
    4956 CH NEt Q1c a bond Me a bond NH O a bond Q3h OH
    4957 CH S Q1a a bond Me a bond NH O a bond Q3g OH
    4958 CH S Q1a a bond Me a bond NH O a bond Q3h OH
    4959 CH S Q1b a bond Me a bond NH O a bond Q3g OH
    4960 CH S Q1b a bond Me a bond NH O a bond Q3h OH
    4961 CH S Q1c a bond Me a bond NH O a bond Q3g OH
    4962 CH S Q1c a bond Me a bond NH O a bond Q3h OH
    4963 CH O Q1a a bond Me a bond NH O a bond Q3g OH
    4964 CH O Q1a a bond Me a bond NH O a bond Q3h OH
    4965 CH O Q1b a bond Me a bond NH O a bond Q3g OH
    4966 CH O Q1b a bond Me a bond NH O a bond Q3h OH
    4967 CH O Q1c a bond Me a bond NH O a bond Q3g OH
    4968 CH O Q1c a bond Me a bond NH O a bond Q3h OH
    4969 CMe NMe Q1a a bond Me a bond NH O a bond Q3g OH
    4970 CMe NMe Q1a a bond Me a bond NH O a bond Q3h OH
    4971 CMe NMe Q1b a bond Me a bond NH O a bond Q3g OH
    4972 CMe NMe Q1b a bond Me a bond NH O a bond Q3h OH
    4973 CMe NMe Q1c a bond Me a bond NH O a bond Q3g OH
    4974 CMe NMe Q1c a bond Me a bond NH O a bond Q3h OH
    4975 CMe NEt Q1a a bond Me a bond NH O a bond Q3g OH
    4976 CMe NEt Q1a a bond Me a bond NH O a bond Q3h OH
    4977 CMe NEt Q1b a bond Me a bond NH O a bond Q3g OH
    4978 CMe NEt Q1b a bond Me a bond NH O a bond Q3h OH
    4979 CMe NEt Q1c a bond Me a bond NH O a bond Q3g OH
    4980 CMe NEt Q1c a bond Me a bond NH O a bond Q3h OH
    4981 CMe S Q1a a bond Me a bond NH O a bond Q3g OH
    4982 CMe S Q1a a bond Me a bond NH O a bond Q3h OH
    4983 CMe S Q1b a bond Me a bond NH O a bond Q3g OH
    4984 CMe S Q1b a bond Me a bond NH O a bond Q3h OH
    4985 CMe S Q1c a bond Me a bond NH O a bond Q3g OH
    4986 CMe S Q1c a bond Me a bond NH O a bond Q3h OH
    4987 CMe O Q1a a bond Me a bond NH O a bond Q3g OH
    4988 CMe O Q1a a bond Me a bond NH O a bond Q3h OH
    4989 CMe O Q1b a bond Me a bond NH O a bond Q3g OH
    4990 CMe O Q1b a bond Me a bond NH O a bond Q3h OH
    4991 CMe O Q1c a bond Me a bond NH O a bond Q3g OH
    4992 CMe O Q1c a bond Me a bond NH O a bond Q3h OH
    4992 CMe O Q1c a bond Me a bond NH O a bond Q3h OH
    4993 CH NH Q1a a bond Me a bond NH S NH Q3a OH
    4994 CH NH Q1a a bond Me a bond NH S NH Q3b OH
    4995 CH NH Q1a a bond Me a bond NH S NH Q3c OH
    4996 CH NH Q1a a bond Me a bond NH S a bond Q3a OH
    4997 CH NH Q1a a bond Me a bond NH S a bond Q3b OH
    4998 CH NH Q1a a bond Me a bond NH S a bond Q3c OH
    4999 CH NH Q1a a bond Me a bond NH O NH Q3a OH
    5000 CH NH Q1a a bond Me a bond NH O NH Q3b OH
    5001 CH NH Q1a a bond Me a bond NH O NH Q3c OH
    5002 CH NH Q1a a bond Me a bond NH O a bond Q3a OH
    5003 CH NH Q1a a bond Me a bond NH O a bond Q3b OH
    5004 CH NH Q1a a bond Me a bond NH O a bond Q3c OH
    5005 CH NH Q1a a bond H a bond NH S NH Q3a OH
    5006 CH NH Q1a a bond H a bond NH S NH Q3b OH
    5007 CH NH Q1a a bond H a bond NH S NH Q3c OH
    5008 CH NH Q1a a bond H a bond NH S a bond Q3a OH
    5009 CH NH Q1a a bond H a bond NH S a bond Q3b OH
    5010 CH NH Q1a a bond H a bond NH S a bond Q3c OH
    5011 CH NH Q1a a bond H a bond NH O NH Q3a OH
    5012 CH NH Q1a a bond H a bond NH O NH Q3b OH
    5013 CH NH Q1a a bond H a bond NH O NH Q3c OH
    5014 CH NH Q1a a bond H a bond NH O a bond Q3a OH
    5015 CH NH Q1a a bond H a bond NH O a bond Q3b OH
    5016 CH NH Q1a a bond H a bond NH O a bond Q3c OH
    5017 CH NH Q1b a bond Me a bond NH S NH Q3a OH
    5018 CH NH Q1b a bond Me a bond NH S NH Q3b OH
    5019 CH NH Q1b a bond Me a bond NH S NH Q3c OH
    5020 CH NH Q1b a bond Me a bond NH S a bond Q3a OH
    5021 CH NH Q1b a bond Me a bond NH S a bond Q3b OH
    5022 CH NH Q1b a bond Me a bond NH S a bond Q3c OH
    5023 CH NH Q1b a bond Me a bond NH O NH Q3a OH
    5024 CH NH Q1b a bond Me a bond NH O NH Q3b OH
    5025 CH NH Q1b a bond Me a bond NH O NH Q3c OH
    5026 CH NH Q1b a bond Me a bond NH O a bond Q3a OH
    5027 CH NH Q1b a bond Me a bond NH O a bond Q3b OH
    5028 CH NH Q1b a bond Me a bond NH O a bond Q3c OH
    5029 CH NH Q1b a bond H a bond NH S NH Q3a OH
    5030 CH NH Q1b a bond H a bond NH S NH Q3b OH
    5031 CH NH Q1b a bond H a bond NH S NH Q3c OH
    5032 CH NH Q1b a bond H a bond NH S a bond Q3a OH
    5033 CH NH Q1b a bond H a bond NH S a bond Q3b OH
    5034 CH NH Q1b a bond H a bond NH S a bond Q3c OH
    5035 CH NH Q1b a bond H a bond NH O NH Q3a OH
    5036 CH NH Q1b a bond H a bond NH O NH Q3b OH
    5037 CH NH Q1b a bond H a bond NH O NH Q3c OH
    5038 CH NH Q1b a bond H a bond NH O a bond Q3a OH
    5039 CH NH Q1b a bond H a bond NH O a bond Q3b OH
    5040 CH NH Q1b a bond H a bond NH O a bond Q3c OH
    5041 CH NH Q1c a bond Me a bond NH S NH Q3a OH
    5042 CH NH Q1c a bond Me a bond NH S NH Q3b OH
    5043 CH NH Q1c a bond Me a bond NH S NH Q3c OH
    5044 CH NH Q1c a bond Me a bond NH S a bond Q3a OH
    5045 CH NH Q1c a bond Me a bond NH S a bond Q3b OH
    5046 CH NH Q1c a bond Me a bond NH S a bond Q3c OH
    5047 CH NH Q1c a bond Me a bond NH O NH Q3a OH
    5048 CH NH Q1c a bond Me a bond NH O NH Q3b OH
    5049 CH NH Q1c a bond Me a bond NH O NH Q3c OH
    5050 CH NH Q1c a bond Me a bond NH O a bond Q3a OH
    5051 CH NH Q1c a bond Me a bond NH O a bond Q3b OH
    5052 CH NH Q1c a bond Me a bond NH O a bond Q3c OH
    5053 CH NH Q1c a bond H a bond NH S NH Q3a OH
    5054 CH NH Q1c a bond H a bond NH S NH Q3b OH
    5055 CH NH Q1c a bond H a bond NH S NH Q3c OH
    5056 CH NH Q1c a bond H a bond NH S a bond Q3a OH
    5057 CH NH Q1c a bond H a bond NH S a bond Q3b OH
    5058 CH NH Q1c a bond H a bond NH S a bond Q3c OH
    5059 CH NH Q1c a bond H a bond NH O NH Q3a OH
    5060 CH NH Q1c a bond H a bond NH O NH Q3b OH
    5061 CH NH Q1c a bond H a bond NH O NH Q3c OH
    5062 CH NH Q1c a bond H a bond NH O a bond Q3a OH
    5063 CH NH Q1c a bond H a bond NH O a bond Q3b OH
    5064 CH NH Q1c a bond H a bond NH O a bond Q3c OH
    5065 CH NH Q1d a bond Me a bond NH S NH Q3a OH
    5066 CH NH Q1d a bond Me a bond NH S NH Q3b OH
    5067 CH NH Q1d a bond Me a bond NH S NH Q3c OH
    5068 CH NH Q1d a bond Me a bond NH S a bond Q3a OH
    5069 CH NH Q1d a bond Me a bond NH S a bond Q3b OH
    5070 CH NH Q1d a bond Me a bond NH S a bond Q3c OH
    5071 CH NH Q1d a bond Me a bond NH O NH Q3a OH
    5072 CH NH Q1d a bond Me a bond NH O NH Q3b OH
    5073 CH NH Q1d a bond Me a bond NH O NH Q3c OH
    5074 CH NH Q1d a bond Me a bond NH O a bond Q3a OH
    5075 CH NH Q1d a bond Me a bond NH O a bond Q3b OH
    5076 CH NH Q1d a bond Me a bond NH O a bond Q3c OH
    5077 CH NH Q1d a bond H a bond NH S NH Q3a OH
    5078 CH NH Q1d a bond H a bond NH S NH Q3b OH
    5079 CH NH Q1d a bond H a bond NH S NH Q3c OH
    5080 CH NH Q1d a bond H a bond NH S a bond Q3a OH
    5081 CH NH Q1d a bond H a bond NH S a bond Q3b OH
    5082 CH NH Q1d a bond H a bond NH S a bond Q3c OH
    5083 CH NH Q1d a bond H a bond NH O NH Q3a OH
    5084 CH NH Q1d a bond H a bond NH O NH Q3b OH
    5085 CH NH Q1d a bond H a bond NH O NH Q3c OH
    5086 CH NH Q1d a bond H a bond NH O a bond Q3a OH
    5087 CH NH Q1d a bond H a bond NH O a bond Q3b OH
    5088 CH NH Q1d a bond H a bond NH O a bond Q3c OH
    5089 CH NH Q1e a bond Me a bond NH S NH Q3a OH
    5090 CH NH Q1e a bond Me a bond NH S NH Q3b OH
    5091 CH NH Q1e a bond Me a bond NH S NH Q3c OH
    5092 CH NH Q1e a bond Me a bond NH S a bond Q3a OH
    5093 CH NH Q1e a bond Me a bond NH S a bond Q3b OH
    5094 CH NH Q1e a bond Me a bond NH S a bond Q3c OH
    5095 CH NH Q1e a bond Me a bond NH O NH Q3a OH
    5096 CH NH Q1e a bond Me a bond NH O NH Q3b OH
    5097 CH NH Q1e a bond Me a bond NH O NH Q3c OH
    5098 CH NH Q1e a bond Me a bond NH O a bond Q3a OH
    5099 CH NH Q1e a bond Me a bond NH O a bond Q3b OH
    5100 CH NH Q1e a bond Me a bond NH O a bond Q3c OH
    5101 CH NH Q1e a bond H a bond NH S NH Q3a OH
    5102 CH NH Q1e a bond H a bond NH S NH Q3b OH
    5103 CH NH Q1e a bond H a bond NH S NH Q3c OH
    5104 CH NH Q1e a bond H a bond NH S a bond Q3a OH
    5105 CH NH Q1e a bond H a bond NH S a bond Q3b OH
    5106 CH NH Q1e a bond H a bond NH S a bond Q3c OH
    5107 CH NH Q1e a bond H a bond NH O NH Q3a OH
    5108 CH NH Q1e a bond H a bond NH O NH Q3b OH
    5109 CH NH Q1e a bond H a bond NH O NH Q3c OH
    5110 CH NH Q1e a bond H a bond NH O a bond Q3a OH
    5111 CH NH Q1e a bond H a bond NH O a bond Q3b OH
    5112 CH NH Q1e a bond H a bond NH O a bond Q3c OH
    5113 CH NH Q1f a bond Me a bond NH S NH Q3a OH
    5114 CH NH Q1f a bond Me a bond NH S NH Q3b OH
    5115 CH NH Q1f a bond Me a bond NH S NH Q3c OH
    5116 CH NH Q1f a bond Me a bond NH S a bond Q3a OH
    5117 CH NH Q1f a bond Me a bond NH S a bond Q3b OH
    5118 CH NH Q1f a bond Me a bond NH S a bond Q3c OH
    5119 CH NH Q1f a bond Me a bond NH O NH Q3a OH
    5120 CH NH Q1f a bond Me a bond NH O NH Q3b OH
    5121 CH NH Q1f a bond Me a bond NH O NH Q3c OH
    5122 CH NH Q1f a bond Me a bond NH O a bond Q3a OH
    5123 CH NH Q1f a bond Me a bond NH O a bond Q3b OH
    5124 CH NH Q1f a bond Me a bond NH O a bond Q3c OH
    5125 CH NH Q1f a bond H a bond NH S NH Q3a OH
    5126 CH NH Q1f a bond H a bond NH S NH Q3b OH
    5127 CH NH Q1f a bond H a bond NH S NH Q3c OH
    5128 CH NH Q1f a bond H a bond NH S a bond Q3a OH
    5129 CH NH Q1f a bond H a bond NH S a bond Q3b OH
    5130 CH NH Q1f a bond H a bond NH S a bond Q3c OH
    5131 CH NH Q1f a bond H a bond NH O NH Q3a OH
    5132 CH NH Q1f a bond H a bond NH O NH Q3b OH
    5133 CH NH Q1f a bond H a bond NH O NH Q3c OH
    5134 CH NH Q1f a bond H a bond NH O a bond Q3a OH
    5135 CH NH Q1f a bond H a bond NH O a bond Q3b OH
    5136 CH NH Q1f a bond H a bond NH O a bond Q3c OH
    5137 CH NH Q1g a bond Me a bond NH S NH Q3a OH
    5138 CH NH Q1g a bond Me a bond NH S NH Q3b OH
    5139 CH NH Q1g a bond Me a bond NH S NH Q3c OH
    5140 CH NH Q1g a bond Me a bond NH S a bond Q3a OH
    5141 CH NH Q1g a bond Me a bond NH S a bond Q3b OH
    5142 CH NH Q1g a bond Me a bond NH S a bond Q3c OH
    5143 CH NH Q1g a bond Me a bond NH O NH Q3a OH
    5144 CH NH Q1g a bond Me a bond NH O NH Q3b OH
    5145 CH NH Q1g a bond Me a bond NH O NH Q3c OH
    5146 CH NH Q1g a bond Me a bond NH O a bond Q3a OH
    5147 CH NH Q1g a bond Me a bond NH O a bond Q3b OH
    5148 CH NH Q1g a bond Me a bond NH O a bond Q3c OH
    5149 CH NH Q1g a bond H a bond NH S NH Q3a OH
    5150 CH NH Q1g a bond H a bond NH S NH Q3b OH
    5151 CH NH Q1g a bond H a bond NH S NH Q3c OH
    5152 CH NH Q1g a bond H a bond NH S a bond Q3a OH
    5153 CH NH Q1g a bond H a bond NH S a bond Q3b OH
    5154 CH NH Q1g a bond H a bond NH S a bond Q3c OH
    5155 CH NH Q1g a bond H a bond NH O NH Q3a OH
    5156 CH NH Q1g a bond H a bond NH O NH Q3b OH
    5157 CH NH Q1g a bond H a bond NH O NH Q3c OH
    5158 CH NH Q1g a bond H a bond NH O a bond Q3a OH
    5159 CH NH Q1g a bond H a bond NH O a bond Q3b OH
    5160 CH NH Q1g a bond H a bond NH O a bond Q3c OH
    5161 CH NH Q1h a bond Me a bond NH S NH Q3a OH
    5162 CH NH Q1h a bond Me a bond NH S NH Q3b OH
    5163 CH NH Q1h a bond Me a bond NH S NH Q3c OH
    5164 CH NH Q1h a bond Me a bond NH S a bond Q3a OH
    5165 CH NH Q1h a bond Me a bond NH S a bond Q3b OH
    5166 CH NH Q1h a bond Me a bond NH S a bond Q3c OH
    5167 CH NH Q1h a bond Me a bond NH O NH Q3a OH
    5168 CH NH Q1h a bond Me a bond NH O NH Q3b OH
    5169 CH NH Q1h a bond Me a bond NH O NH Q3c OH
    5170 CH NH Q1h a bond Me a bond NH O a bond Q3a OH
    5171 CH NH Q1h a bond Me a bond NH O a bond Q3b OH
    5172 CH NH Q1h a bond Me a bond NH O a bond Q3c OH
    5173 CH NH Q1h a bond H a bond NH S NH Q3a OH
    5174 CH NH Q1h a bond H a bond NH S NH Q3b OH
    5175 CH NH Q1h a bond H a bond NH S NH Q3c OH
    5176 CH NH Q1h a bond H a bond NH S a bond Q3a OH
    5177 CH NH Q1h a bond H a bond NH S a bond Q3b OH
    5178 CH NH Q1h a bond H a bond NH S a bond Q3c OH
    5179 CH NH Q1h a bond H a bond NH O NH Q3a OH
    5180 CH NH Q1h a bond H a bond NH O NH Q3b OH
    5181 CH NH Q1h a bond H a bond NH O NH Q3c OH
    5182 CH NH Q1h a bond H a bond NH O a bond Q3a OH
    5183 CH NH Q1h a bond H a bond NH O a bond Q3b OH
    5184 CH NH Q1h a bond H a bond NH O a bond Q3c OH
    5185 CH NH Q1i a bond Me a bond NH S NH Q3a OH
    5186 CH NH Q1i a bond Me a bond NH S NH Q3b OH
    5187 CH NH Q1i a bond Me a bond NH S NH Q3c OH
    5188 CH NH Q1i a bond Me a bond NH S a bond Q3a OH
    5189 CH NH Q1i a bond Me a bond NH S a bond Q3b OH
    5190 CH NH Q1i a bond Me a bond NH S a bond Q3c OH
    5191 CH NH Q1i a bond Me a bond NH O NH Q3a OH
    5192 CH NH Q1i a bond Me a bond NH O NH Q3b OH
    5193 CH NH Q1i a bond Me a bond NH O NH Q3c OH
    5194 CH NH Q1i a bond Me a bond NH O a bond Q3a OH
    5195 CH NH Q1i a bond Me a bond NH O a bond Q3b OH
    5196 CH NH Q1i a bond Me a bond NH O a bond Q3c OH
    5197 CH NH Q1i a bond H a bond NH S NH Q3a OH
    5198 CH NH Q1i a bond H a bond NH S NH Q3b OH
    5199 CH NH Q1i a bond H a bond NH S NH Q3c OH
    5200 CH NH Q1i a bond H a bond NH S a bond Q3a OH
    5201 CH NH Q1i a bond H a bond NH S a bond Q3b OH
    5202 CH NH Q1i a bond H a bond NH S a bond Q3c OH
    5203 CH NH Q1i a bond H a bond NH O NH Q3a OH
    5204 CH NH Q1i a bond H a bond NH O NH Q3b OH
    5205 CH NH Q1i a bond H a bond NH O NH Q3c OH
    5206 CH NH Q1i a bond H a bond NH O a bond Q3a OH
    5207 CH NH Q1i a bond H a bond NH O a bond Q3b OH
    5208 CH NH Q1i a bond H a bond NH O a bond Q3c OH
    5209 CH NH Q1j a bond Me a bond NH S NH Q3a OH
    5210 CH NH Q1j a bond Me a bond NH S NH Q3b OH
    5211 CH NH Q1j a bond Me a bond NH S NH Q3c OH
    5212 CH NH Q1j a bond Me a bond NH S a bond Q3a OH
    5213 CH NH Q1j a bond Me a bond NH S a bond Q3b OH
    5214 CH NH Q1j a bond Me a bond NH S a bond Q3c OH
    5215 CH NH Q1j a bond Me a bond NH O NH Q3a OH
    5216 CH NH Q1j a bond Me a bond NH O NH Q3b OH
    5217 CH NH Q1j a bond Me a bond NH O NH Q3c OH
    5218 CH NH Q1j a bond Me a bond NH O a bond Q3a OH
    5219 CH NH Q1j a bond Me a bond NH O a bond Q3b OH
    5220 CH NH Q1j a bond Me a bond NH O a bond Q3c OH
    5221 CH NH Q1j a bond H a bond NH S NH Q3a OH
    5222 CH NH Q1j a bond H a bond NH S NH Q3b OH
    5223 CH NH Q1j a bond H a bond NH S NH Q3c OH
    5224 CH NH Q1j a bond H a bond NH S a bond Q3a OH
    5225 CH NH Q1j a bond H a bond NH S a bond Q3b OH
    5226 CH NH Q1j a bond H a bond NH S a bond Q3c OH
    5227 CH NH Q1j a bond H a bond NH O NH Q3a OH
    5228 CH NH Q1j a bond H a bond NH O NH Q3b OH
    5229 CH NH Q1j a bond H a bond NH O NH Q3c OH
    5230 CH NH Q1j a bond H a bond NH O a bond Q3a OH
    5231 CH NH Q1j a bond H a bond NH O a bond Q3b OH
    5232 CH NH Q1j a bond H a bond NH O a bond Q3c OH
    5233 CMe NH Q1a a bond Me a bond NH S NH Q3a OH
    5234 CMe NH Q1a a bond Me a bond NH S NH Q3b OH
    5235 CMe NH Q1a a bond Me a bond NH S NH Q3c OH
    5236 CMe NH Q1a a bond Me a bond NH S a bond Q3a OH
    5237 CMe NH Q1a a bond Me a bond NH S a bond Q3b OH
    5238 CMe NH Q1a a bond Me a bond NH S a bond Q3c OH
    5239 CMe NH Q1a a bond Me a bond NH O NH Q3a OH
    5240 CMe NH Q1a a bond Me a bond NH O NH Q3b OH
    5241 CMe NH Q1a a bond Me a bond NH O NH Q3c OH
    5242 CMe NH Q1a a bond Me a bond NH O a bond Q3a OH
    5243 CMe NH Q1a a bond Me a bond NH O a bond Q3b OH
    5244 CMe NH Q1a a bond Me a bond NH O a bond Q3c OH
    5245 CMe NH Q1a a bond H a bond NH S NH Q3a OH
    5246 CMe NH Q1a a bond H a bond NH S NH Q3b OH
    5247 CMe NH Q1a a bond H a bond NH S NH Q3c OH
    5248 CMe NH Q1a a bond H a bond NH S a bond Q3a OH
    5249 CMe NH Q1a a bond H a bond NH S a bond Q3b OH
    5250 CMe NH Q1a a bond H a bond NH S a bond Q3c OH
    5251 CMe NH Q1a a bond H a bond NH O NH Q3a OH
    5252 CMe NH Q1a a bond H a bond NH O NH Q3b OH
    5253 CMe NH Q1a a bond H a bond NH O NH Q3c OH
    5254 CMe NH Q1a a bond H a bond NH O a bond Q3a OH
    5255 CMe NH Q1a a bond H a bond NH O a bond Q3b OH
    5256 CMe NH Q1a a bond H a bond NH O a bond Q3c OH
    5257 CMe NH Q1b a bond Me a bond NH S NH Q3a OH
    5258 CMe NH Q1b a bond Me a bond NH S NH Q3b OH
    5259 CMe NH Q1b a bond Me a bond NH S NH Q3c OH
    5260 CMe NH Q1b a bond Me a bond NH S a bond Q3a OH
    5261 CMe NH Q1b a bond Me a bond NH S a bond Q3b OH
    5262 CMe NH Q1b a bond Me a bond NH S a bond Q3c OH
    5263 CMe NH Q1b a bond Me a bond NH O NH Q3a OH
    5264 CMe NH Q1b a bond Me a bond NH O NH Q3b OH
    5265 CMe NH Q1b a bond Me a bond NH O NH Q3c OH
    5266 CMe NH Q1b a bond Me a bond NH O a bond Q3a OH
    5267 CMe NH Q1b a bond Me a bond NH O a bond Q3b OH
    5268 CMe NH Q1b a bond Me a bond NH O a bond Q3c OH
    5269 CMe NH Q1b a bond H a bond NH S NH Q3a OH
    5270 CMe NH Q1b a bond H a bond NH S NH Q3b OH
    5271 CMe NH Q1b a bond H a bond NH S NH Q3c OH
    5272 CMe NH Q1b a bond H a bond NH S a bond Q3a OH
    5273 CMe NH Q1b a bond H a bond NH S a bond Q3b OH
    5274 CMe NH Q1b a bond H a bond NH S a bond Q3c OH
    5275 CMe NH Q1b a bond H a bond NH O NH Q3a OH
    5276 CMe NH Q1b a bond H a bond NH O NH Q3b OH
    5277 CMe NH Q1b a bond H a bond NH O NH Q3c OH
    5278 CMe NH Q1b a bond H a bond NH O a bond Q3a OH
    5279 CMe NH Q1b a bond H a bond NH O a bond Q3b OH
    5280 CMe NH Q1b a bond H a bond NH O a bond Q3c OH
    5281 CMe NH Q1c a bond Me a bond NH S NH Q3a OH
    5282 CMe NH Q1c a bond Me a bond NH S NH Q3b OH
    5283 CMe NH Q1c a bond Me a bond NH S NH Q3c OH
    5284 CMe NH Q1c a bond Me a bond NH S a bond Q3a OH
    5285 CMe NH Q1c a bond Me a bond NH S a bond Q3b OH
    5286 CMe NH Q1c a bond Me a bond NH S a bond Q3c OH
    5287 CMe NH Q1c a bond Me a bond NH O NH Q3a OH
    5288 CMe NH Q1c a bond Me a bond NH O NH Q3b OH
    5289 CMe NH Q1c a bond Me a bond NH O NH Q3c OH
    5290 CMe NH Q1c a bond Me a bond NH O a bond Q3a OH
    5291 CMe NH Q1c a bond Me a bond NH O a bond Q3b OH
    5292 CMe NH Q1c a bond Me a bond NH O a bond Q3c OH
    5293 CMe NH Q1c a bond H a bond NH S NH Q3a OH
    5294 CMe NH Q1c a bond H a bond NH S NH Q3b OH
    5295 CMe NH Q1c a bond H a bond NH S NH Q3c OH
    5296 CMe NH Q1c a bond H a bond NH S a bond Q3a OH
    5297 CMe NH Q1c a bond H a bond NH S a bond Q3b OH
    5298 CMe NH Q1c a bond H a bond NH S a bond Q3c OH
    5299 CMe NH Q1c a bond H a bond NH O NH Q3a OH
    5300 CMe NH Q1c a bond H a bond NH O NH Q3b OH
    5301 CMe NH Q1c a bond H a bond NH O NH Q3c OH
    5302 CMe NH Q1c a bond H a bond NH O a bond Q3a OH
    5303 CMe NH Q1c a bond H a bond NH O a bond Q3b OH
    5304 CMe NH Q1c a bond H a bond NH O a bond Q3c OH
    5305 CMe NH Q1d a bond Me a bond NH S NH Q3a OH
    5306 CMe NH Q1d a bond Me a bond NH S NH Q3b OH
    5307 CMe NH Q1d a bond Me a bond NH S NH Q3c OH
    5308 CMe NH Q1d a bond Me a bond NH S a bond Q3a OH
    5309 CMe NH Q1d a bond Me a bond NH S a bond Q3b OH
    5310 CMe NH Q1d a bond Me a bond NH S a bond Q3c OH
    5311 CMe NH Q1d a bond Me a bond NH O NH Q3a OH
    5312 CMe NH Q1d a bond Me a bond NH O NH Q3b OH
    5313 CMe NH Q1d a bond Me a bond NH O NH Q3c OH
    5314 CMe NH Q1d a bond Me a bond NH O a bond Q3a OH
    5315 CMe NH Q1d a bond Me a bond NH O a bond Q3b OH
    5316 CMe NH Q1d a bond Me a bond NH O a bond Q3c OH
    5317 CMe NH Q1d a bond H a bond NH S NH Q3a OH
    5318 CMe NH Q1d a bond H a bond NH S NH Q3b OH
    5319 CMe NH Q1d a bond H a bond NH S NH Q3c OH
    5320 CMe NH Q1d a bond H a bond NH S a bond Q3a OH
    5321 CMe NH Q1d a bond H a bond NH S a bond Q3b OH
    5322 CMe NH Q1d a bond H a bond NH S a bond Q3c OH
    5323 CMe NH Q1d a bond H a bond NH O NH Q3a OH
    5324 CMe NH Q1d a bond H a bond NH O NH Q3b OH
    5325 CMe NH Q1d a bond H a bond NH O NH Q3c OH
    5326 CMe NH Q1d a bond H a bond NH O a bond Q3a OH
    5327 CMe NH Q1d a bond H a bond NH O a bond Q3b OH
    5328 CMe NH Q1d a bond H a bond NH O a bond Q3c OH
    5329 CMe NH Q1e a bond Me a bond NH S NH Q3a OH
    5330 CMe NH Q1e a bond Me a bond NH S NH Q3b OH
    5331 CMe NH Q1e a bond Me a bond NH S NH Q3c OH
    5332 CMe NH Q1e a bond Me a bond NH S a bond Q3a OH
    5333 CMe NH Q1e a bond Me a bond NH S a bond Q3b OH
    5334 CMe NH Q1e a bond Me a bond NH S a bond Q3c OH
    5335 CMe NH Q1e a bond Me a bond NH O NH Q3a OH
    5336 CMe NH Q1e a bond Me a bond NH O NH Q3b OH
    5337 CMe NH Q1e a bond Me a bond NH O NH Q3c OH
    5338 CMe NH Q1e a bond Me a bond NH O a bond Q3a OH
    5339 CMe NH Q1e a bond Me a bond NH O a bond Q3b OH
    5340 CMe NH Q1e a bond Me a bond NH O a bond Q3c OH
    5341 CMe NH Q1e a bond H a bond NH S NH Q3a OH
    5342 CMe NH Q1e a bond H a bond NH S NH Q3b OH
    5343 CMe NH Q1e a bond H a bond NH S NH Q3c OH
    5344 CMe NH Q1e a bond H a bond NH S a bond Q3a OH
    5345 CMe NH Q1e a bond H a bond NH S a bond Q3b OH
    5346 CMe NH Q1e a bond H a bond NH S a bond Q3c OH
    5347 CMe NH Q1e a bond H a bond NH O NH Q3a OH
    5348 CMe NH Q1e a bond H a bond NH O NH Q3b OH
    5349 CMe NH Q1e a bond H a bond NH O NH Q3c OH
    5350 CMe NH Q1e a bond H a bond NH O a bond Q3a OH
    5351 CMe NH Q1e a bond H a bond NH O a bond Q3b OH
    5352 CMe NH Q1e a bond H a bond NH O a bond Q3c OH
    5353 CMe NH Q1f a bond Me a bond NH S NH Q3a OH
    5354 CMe NH Q1f a bond Me a bond NH S NH Q3b OH
    5355 CMe NH Q1f a bond Me a bond NH S NH Q3c OH
    5356 CMe NH Q1f a bond Me a bond NH S a bond Q3a OH
    5357 CMe NH Q1f a bond Me a bond NH S a bond Q3b OH
    5358 CMe NH Q1f a bond Me a bond NH S a bond Q3c OH
    5359 CMe NH Q1f a bond Me a bond NH O NH Q3a OH
    5360 CMe NH Q1f a bond Me a bond NH O NH Q3b OH
    5361 CMe NH Q1f a bond Me a bond NH O NH Q3c OH
    5362 CMe NH Q1f a bond Me a bond NH O a bond Q3a OH
    5363 CMe NH Q1f a bond Me a bond NH O a bond Q3b OH
    5364 CMe NH Q1f a bond Me a bond NH O a bond Q3c OH
    5365 CMe NH Q1f a bond H a bond NH S NH Q3a OH
    5366 CMe NH Q1f a bond H a bond NH S NH Q3b OH
    5367 CMe NH Q1f a bond H a bond NH S NH Q3c OH
    5368 CMe NH Q1f a bond H a bond NH S a bond Q3a OH
    5369 CMe NH Q1f a bond H a bond NH S a bond Q3b OH
    5370 CMe NH Q1f a bond H a bond NH S a bond Q3c OH
    5371 CMe NH Q1f a bond H a bond NH O NH Q3a OH
    5372 CMe NH Q1f a bond H a bond NH O NH Q3b OH
    5373 CMe NH Q1f a bond H a bond NH O NH Q3c OH
    5374 CMe NH Q1f a bond H a bond NH O a bond Q3a OH
    5375 CMe NH Q1f a bond H a bond NH O a bond Q3b OH
    5376 CMe NH Q1f a bond H a bond NH O a bond Q3c OH
    5377 CMe NH Q1g a bond Me a bond NH S NH Q3a OH
    5378 CMe NH Q1g a bond Me a bond NH S NH Q3b OH
    5379 CMe NH Q1g a bond Me a bond NH S NH Q3c OH
    5380 CMe NH Q1g a bond Me a bond NH S a bond Q3a OH
    5381 CMe NH Q1g a bond Me a bond NH S a bond Q3b OH
    5382 CMe NH Q1g a bond Me a bond NH S a bond Q3c OH
    5383 CMe NH Q1g a bond Me a bond NH O NH Q3a OH
    5384 CMe NH Q1g a bond Me a bond NH O NH Q3b OH
    5385 CMe NH Q1g a bond Me a bond NH O NH Q3c OH
    5386 CMe NH Q1g a bond Me a bond NH O a bond Q3a OH
    5387 CMe NH Q1g a bond Me a bond NH O a bond Q3b OH
    5388 CMe NH Q1g a bond Me a bond NH O a bond Q3c OH
    5389 CMe NH Q1g a bond H a bond NH S NH Q3a OH
    5390 CMe NH Q1g a bond H a bond NH S NH Q3b OH
    5391 CMe NH Q1g a bond H a bond NH S NH Q3c OH
    5392 CMe NH Q1g a bond H a bond NH S a bond Q3a OH
    5393 CMe NH Q1g a bond H a bond NH S a bond Q3b OH
    5394 CMe NH Q1g a bond H a bond NH S a bond Q3c OH
    5395 CMe NH Q1g a bond H a bond NH O NH Q3a OH
    5396 CMe NH Q1g a bond H a bond NH O NH Q3b OH
    5397 CMe NH Q1g a bond H a bond NH O NH Q3c OH
    5398 CMe NH Q1g a bond H a bond NH O a bond Q3a OH
    5399 CMe NH Q1g a bond H a bond NH O a bond Q3b OH
    5400 CMe NH Q1g a bond H a bond NH O a bond Q3c OH
    5401 CMe NH Q1h a bond Me a bond NH S NH Q3a OH
    5402 CMe NH Q1h a bond Me a bond NH S NH Q3b OH
    5403 CMe NH Q1h a bond Me a bond NH S NH Q3c OH
    5404 CMe NH Q1h a bond Me a bond NH S a bond Q3a OH
    5405 CMe NH Q1h a bond Me a bond NH S a bond Q3b OH
    5406 CMe NH Q1h a bond Me a bond NH S a bond Q3c OH
    5407 CMe NH Q1h a bond Me a bond NH O NH Q3a OH
    5408 CMe NH Q1h a bond Me a bond NH O NH Q3b OH
    5409 CMe NH Q1h a bond Me a bond NH O NH Q3c OH
    5410 CMe NH Q1h a bond Me a bond NH O a bond Q3a OH
    5411 CMe NH Q1h a bond Me a bond NH O a bond Q3b OH
    5412 CMe NH Q1h a bond Me a bond NH O a bond Q3c OH
    5413 CMe NH Q1h a bond H a bond NH S NH Q3a OH
    5414 CMe NH Q1h a bond H a bond NH S NH Q3b OH
    5415 CMe NH Q1h a bond H a bond NH S NH Q3c OH
    5416 CMe NH Q1h a bond H a bond NH S a bond Q3a OH
    5417 CMe NH Q1h a bond H a bond NH S a bond Q3b OH
    5418 CMe NH Q1h a bond H a bond NH S a bond Q3c OH
    5419 CMe NH Q1h a bond H a bond NH O NH Q3a OH
    5420 CMe NH Q1h a bond H a bond NH O NH Q3b OH
    5421 CMe NH Q1h a bond H a bond NH O NH Q3c OH
    5422 CMe NH Q1h a bond H a bond NH O a bond Q3a OH
    5423 CMe NH Q1h a bond H a bond NH O a bond Q3b OH
    5424 CMe NH Q1h a bond H a bond NH O a bond Q3c OH
    5425 CMe NH Q1i a bond Me a bond NH S NH Q3a OH
    5426 CMe NH Q1i a bond Me a bond NH S NH Q3b OH
    5427 CMe NH Q1i a bond Me a bond NH S NH Q3c OH
    5428 CMe NH Q1i a bond Me a bond NH S a bond Q3a OH
    5429 CMe NH Q1i a bond Me a bond NH S a bond Q3b OH
    5430 CMe NH Q1i a bond Me a bond NH S a bond Q3c OH
    5431 CMe NH Q1i a bond Me a bond NH O NH Q3a OH
    5432 CMe NH Q1i a bond Me a bond NH O NH Q3b OH
    5433 CMe NH Q1i a bond Me a bond NH O NH Q3c OH
    5434 CMe NH Q1i a bond Me a bond NH O a bond Q3a OH
    5435 CMe NH Q1i a bond Me a bond NH O a bond Q3b OH
    5436 CMe NH Q1i a bond Me a bond NH O a bond Q3c OH
    5437 CMe NH Q1i a bond H a bond NH S NH Q3a OH
    5438 CMe NH Q1i a bond H a bond NH S NH Q3b OH
    5439 CMe NH Q1i a bond H a bond NH S NH Q3c OH
    5440 CMe NH Q1i a bond H a bond NH S a bond Q3a OH
    5441 CMe NH Q1i a bond H a bond NH S a bond Q3b OH
    5442 CMe NH Q1i a bond H a bond NH S a bond Q3c OH
    5443 CMe NH Q1i a bond H a bond NH O NH Q3a OH
    5444 CMe NH Q1i a bond H a bond NH O NH Q3b OH
    5445 CMe NH Q1i a bond H a bond NH O NH Q3c OH
    5446 CMe NH Q1i a bond H a bond NH O a bond Q3a OH
    5447 CMe NH Q1i a bond H a bond NH O a bond Q3b OH
    5448 CMe NH Q1i a bond H a bond NH O a bond Q3c OH
    5449 CMe NH Q1j a bond Me a bond NH S NH Q3a OH
    5450 CMe NH Q1j a bond Me a bond NH S NH Q3b OH
    5451 CMe NH Q1j a bond Me a bond NH S NH Q3c OH
    5452 CMe NH Q1j a bond Me a bond NH S a bond Q3a OH
    5453 CMe NH Q1j a bond Me a bond NH S a bond Q3b OH
    5454 CMe NH Q1j a bond Me a bond NH S a bond Q3c OH
    5455 CMe NH Q1j a bond Me a bond NH O NH Q3a OH
    5456 CMe NH Q1j a bond Me a bond NH O NH Q3b OH
    5457 CMe NH Q1j a bond Me a bond NH O NH Q3c OH
    5458 CMe NH Q1j a bond Me a bond NH O a bond Q3a OH
    5459 CMe NH Q1j a bond Me a bond NH O a bond Q3b OH
    5460 CMe NH Q1j a bond Me a bond NH O a bond Q3c OH
    5461 CMe NH Q1j a bond H a bond NH S NH Q3a OH
    5462 CMe NH Q1j a bond H a bond NH S NH Q3b OH
    5463 CMe NH Q1j a bond H a bond NH S NH Q3c OH
    5464 CMe NH Q1j a bond H a bond NH S a bond Q3a OH
    5465 CMe NH Q1j a bond H a bond NH S a bond Q3b OH
    5466 CMe NH Q1j a bond H a bond NH S a bond Q3c OH
    5467 CMe NH Q1j a bond H a bond NH O NH Q3a OH
    5468 CMe NH Q1j a bond H a bond NH O NH Q3b OH
    5469 CMe NH Q1j a bond H a bond NH O NH Q3c OH
    5470 CMe NH Q1j a bond H a bond NH O a bond Q3a OH
    5471 CMe NH Q1j a bond H a bond NH O a bond Q3b OH
    5472 CMe NH Q1j a bond H a bond NH O a bond Q3c OH
  • 69) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 2 denote the flowing substituents.
  • Figure US20140051857A1-20140220-C00006
  • TABLE 2
    No A B R1 L1 R2 L2 L3 Y L4 R3 X
    1 N NMe Q1o a bond Me a bond NH S NH Q3a OH
    2 N NMe Q1o a bond Me a bond NH S NH Q3b OH
    3 N NMe Q1o a bond Me a bond NH S NH Q3c OH
    4 N NMe Q1o a bond Me a bond NH S a bond Q3a OH
    5 N NMe Q1o a bond Me a bond NH S a bond Q3b OH
    6 N NMe Q1o a bond Me a bond NH S a bond Q3c OH
    7 N NMe Q1o a bond Me a bond NH O NH Q3a OH
    8 N NMe Q1o a bond Me a bond NH O NH Q3b OH
    9 N NMe Q1o a bond Me a bond NH O NH Q3c OH
    10 N NMe Q1o a bond Me a bond NH O a bond Q3a OH
    11 N NMe Q1o a bond Me a bond NH O a bond Q3b OH
    12 N NMe Q1o a bond Me a bond NH O a bond Q3c OH
    13 N NMe Q1o a bond H a bond NH S NH Q3a OH
    14 N NMe Q1o a bond H a bond NH S NH Q3b OH
    15 N NMe Q1o a bond H a bond NH S NH Q3c OH
    16 N NMe Q1o a bond H a bond NH S a bond Q3a OH
    17 N NMe Q1o a bond H a bond NH S a bond Q3b OH
    18 N NMe Q1o a bond H a bond NH S a bond Q3c OH
    19 N NMe Q1o a bond H a bond NH O NH Q3a OH
    20 N NMe Q1o a bond H a bond NH O NH Q3b OH
    21 N NMe Q1o a bond H a bond NH O NH Q3c OH
    22 N NMe Q1o a bond H a bond NH O a bond Q3a OH
    23 N NMe Q1o a bond H a bond NH O a bond Q3b OH
    24 N NMe Q1o a bond H a bond NH O a bond Q3c OH
    25 N NMe Q1p a bond Me a bond NH S NH Q3a OH
    26 N NMe Q1p a bond Me a bond NH S NH Q3b OH
    27 N NMe Q1p a bond Me a bond NH S NH Q3c OH
    28 N NMe Q1p a bond Me a bond NH S a bond Q3a OH
    29 N NMe Q1p a bond Me a bond NH S a bond Q3b OH
    30 N NMe Q1p a bond Me a bond NH S a bond Q3c OH
    31 N NMe Q1p a bond Me a bond NH O NH Q3a OH
    32 N NMe Q1p a bond Me a bond NH O NH Q3b OH
    33 N NMe Q1p a bond Me a bond NH O NH Q3c OH
    34 N NMe Q1p a bond Me a bond NH O a bond Q3a OH
    35 N NMe Q1p a bond Me a bond NH O a bond Q3b OH
    36 N NMe Q1p a bond Me a bond NH O a bond Q3c OH
    37 N NMe Q1p a bond H a bond NH S NH Q3a OH
    38 N NMe Q1p a bond H a bond NH S NH Q3b OH
    39 N NMe Q1p a bond H a bond NH S NH Q3c OH
    40 N NMe Q1p a bond H a bond NH S a bond Q3a OH
    41 N NMe Q1p a bond H a bond NH S a bond Q3b OH
    42 N NMe Q1p a bond H a bond NH S a bond Q3c OH
    43 N NMe Q1p a bond H a bond NH O NH Q3a OH
    44 N NMe Q1p a bond H a bond NH O NH Q3b OH
    45 N NMe Q1p a bond H a bond NH O NH Q3c OH
    46 N NMe Q1p a bond H a bond NH O a bond Q3a OH
    47 N NMe Q1p a bond H a bond NH O a bond Q3b OH
    48 N NMe Q1p a bond H a bond NH O a bond Q3c OH
    49 N NMe Q1q a bond Me a bond NH S NH Q3a OH
    50 N NMe Q1q a bond Me a bond NH S NH Q3b OH
    51 N NMe Q1q a bond Me a bond NH S NH Q3c OH
    52 N NMe Q1q a bond Me a bond NH S a bond Q3a OH
    53 N NMe Q1q a bond Me a bond NH S a bond Q3b OH
    54 N NMe Q1q a bond Me a bond NH S a bond Q3c OH
    55 N NMe Q1q a bond Me a bond NH O NH Q3a OH
    56 N NMe Q1q a bond Me a bond NH O NH Q3b OH
    57 N NMe Q1q a bond Me a bond NH O NH Q3c OH
    58 N NMe Q1q a bond Me a bond NH O a bond Q3a OH
    59 N NMe Q1q a bond Me a bond NH O a bond Q3b OH
    60 N NMe Q1q a bond Me a bond NH O a bond Q3c OH
    61 N NMe Q1q a bond H a bond NH S NH Q3a OH
    62 N NMe Q1q a bond H a bond NH S NH Q3b OH
    63 N NMe Q1q a bond H a bond NH S NH Q3c OH
    64 N NMe Q1q a bond H a bond NH S a bond Q3a OH
    65 N NMe Q1q a bond H a bond NH S a bond Q3b OH
    66 N NMe Q1q a bond H a bond NH S a bond Q3c OH
    67 N NMe Q1q a bond H a bond NH O NH Q3a OH
    68 N NMe Q1q a bond H a bond NH O NH Q3b OH
    69 N NMe Q1q a bond H a bond NH O NH Q3c OH
    70 N NMe Q1q a bond H a bond NH O a bond Q3a OH
    71 N NMe Q1q a bond H a bond NH O a bond Q3b OH
    72 N NMe Q1q a bond H a bond NH O a bond Q3c OH
    73 N NMe Q1r a bond Me a bond NH S NH Q3a OH
    74 N NMe Q1r a bond Me a bond NH S NH Q3b OH
    75 N NMe Q1r a bond Me a bond NH S NH Q3c OH
    76 N NMe Q1r a bond Me a bond NH S a bond Q3a OH
    77 N NMe Q1r a bond Me a bond NH S a bond Q3b OH
    78 N NMe Q1r a bond Me a bond NH S a bond Q3c OH
    79 N NMe Q1r a bond Me a bond NH O NH Q3a OH
    80 N NMe Q1r a bond Me a bond NH O NH Q3b OH
    81 N NMe Q1r a bond Me a bond NH O NH Q3c OH
    82 N NMe Q1r a bond Me a bond NH O a bond Q3a OH
    83 N NMe Q1r a bond Me a bond NH O a bond Q3b OH
    84 N NMe Q1r a bond Me a bond NH O a bond Q3c OH
    85 N NMe Q1r a bond H a bond NH S NH Q3a OH
    86 N NMe Q1r a bond H a bond NH S NH Q3b OH
    87 N NMe Q1r a bond H a bond NH S NH Q3c OH
    88 N NMe Q1r a bond H a bond NH S a bond Q3a OH
    89 N NMe Q1r a bond H a bond NH S a bond Q3b OH
    90 N NMe Q1r a bond H a bond NH S a bond Q3c OH
    91 N NMe Q1r a bond H a bond NH O NH Q3a OH
    92 N NMe Q1r a bond H a bond NH O NH Q3b OH
    93 N NMe Q1r a bond H a bond NH O NH Q3c OH
    94 N NMe Q1r a bond H a bond NH O a bond Q3a OH
    95 N NMe Q1r a bond H a bond NH O a bond Q3b OH
    96 N NMe Q1r a bond H a bond NH O a bond Q3c OH
    97 N NMe Q1s a bond Me a bond NH S NH Q3a OH
    98 N NMe Q1s a bond Me a bond NH S NH Q3b OH
    99 N NMe Q1s a bond Me a bond NH S NH Q3c OH
    100 N NMe Q1s a bond Me a bond NH S a bond Q3a OH
    101 N NMe Q1s a bond Me a bond NH S a bond Q3b OH
    102 N NMe Q1s a bond Me a bond NH S a bond Q3c OH
    103 N NMe Q1s a bond Me a bond NH O NH Q3a OH
    104 N NMe Q1s a bond Me a bond NH O NH Q3b OH
    105 N NMe Q1s a bond Me a bond NH O NH Q3c OH
    106 N NMe Q1s a bond Me a bond NH O a bond Q3a OH
    107 N NMe Q1s a bond Me a bond NH O a bond Q3b OH
    108 N NMe Q1s a bond Me a bond NH O a bond Q3c OH
    109 N NMe Q1s a bond H a bond NH S NH Q3a OH
    110 N NMe Q1s a bond H a bond NH S NH Q3b OH
    111 N NMe Q1s a bond H a bond NH S NH Q3c OH
    112 N NMe Q1s a bond H a bond NH S a bond Q3a OH
    113 N NMe Q1s a bond H a bond NH S a bond Q3b OH
    114 N NMe Q1s a bond H a bond NH S a bond Q3c OH
    115 N NMe Q1s a bond H a bond NH O NH Q3a OH
    116 N NMe Q1s a bond H a bond NH O NH Q3b OH
    117 N NMe Q1s a bond H a bond NH O NH Q3c OH
    118 N NMe Q1s a bond H a bond NH O a bond Q3a OH
    119 N NMe Q1s a bond H a bond NH O a bond Q3b OH
    120 N NMe Q1s a bond H a bond NH O a bond Q3c OH
    121 N NMe Q1t a bond Me a bond NH S NH Q3a OH
    122 N NMe Q1t a bond Me a bond NH S NH Q3b OH
    123 N NMe Q1t a bond Me a bond NH S NH Q3c OH
    124 N NMe Q1t a bond Me a bond NH S a bond Q3a OH
    125 N NMe Q1t a bond Me a bond NH S a bond Q3b OH
    126 N NMe Q1t a bond Me a bond NH S a bond Q3c OH
    127 N NMe Q1t a bond Me a bond NH O NH Q3a OH
    128 N NMe Q1t a bond Me a bond NH O NH Q3b OH
    129 N NMe Q1t a bond Me a bond NH O NH Q3c OH
    130 N NMe Q1t a bond Me a bond NH O a bond Q3a OH
    131 N NMe Q1t a bond Me a bond NH O a bond Q3b OH
    132 N NMe Q1t a bond Me a bond NH O a bond Q3c OH
    133 N NMe Q1t a bond H a bond NH S NH Q3a OH
    134 N NMe Q1t a bond H a bond NH S NH Q3b OH
    135 N NMe Q1t a bond H a bond NH S NH Q3c OH
    136 N NMe Q1t a bond H a bond NH S a bond Q3a OH
    137 N NMe Q1t a bond H a bond NH S a bond Q3b OH
    138 N NMe Q1t a bond H a bond NH S a bond Q3c OH
    139 N NMe Q1t a bond H a bond NH O NH Q3a OH
    140 N NMe Q1t a bond H a bond NH O NH Q3b OH
    141 N NMe Q1t a bond H a bond NH O NH Q3c OH
    142 N NMe Q1t a bond H a bond NH O a bond Q3a OH
    143 N NMe Q1t a bond H a bond NH O a bond Q3b OH
    144 N NMe Q1t a bond H a bond NH O a bond Q3c OH
    145 N NMe Q1u a bond Me a bond NH S NH Q3a OH
    146 N NMe Q1u a bond Me a bond NH S NH Q3b OH
    147 N NMe Q1u a bond Me a bond NH S NH Q3c OH
    148 N NMe Q1u a bond Me a bond NH S a bond Q3a OH
    149 N NMe Q1u a bond Me a bond NH S a bond Q3b OH
    150 N NMe Q1u a bond Me a bond NH S a bond Q3c OH
    151 N NMe Q1u a bond Me a bond NH O NH Q3a OH
    152 N NMe Q1u a bond Me a bond NH O NH Q3b OH
    153 N NMe Q1u a bond Me a bond NH O NH Q3c OH
    154 N NMe Q1u a bond Me a bond NH O a bond Q3a OH
    155 N NMe Q1u a bond Me a bond NH O a bond Q3b OH
    156 N NMe Q1u a bond Me a bond NH O a bond Q3c OH
    157 N NMe Q1u a bond H a bond NH S NH Q3a OH
    158 N NMe Q1u a bond H a bond NH S NH Q3b OH
    159 N NMe Q1u a bond H a bond NH S NH Q3c OH
    160 N NMe Q1u a bond H a bond NH S a bond Q3a OH
    161 N NMe Q1u a bond H a bond NH S a bond Q3b OH
    162 N NMe Q1u a bond H a bond NH S a bond Q3c OH
    163 N NMe Q1u a bond H a bond NH O NH Q3a OH
    164 N NMe Q1u a bond H a bond NH O NH Q3b OH
    165 N NMe Q1u a bond H a bond NH O NH Q3c OH
    166 N NMe Q1u a bond H a bond NH O a bond Q3a OH
    167 N NMe Q1u a bond H a bond NH O a bond Q3b OH
    168 N NMe Q1u a bond H a bond NH O a bond Q3c OH
    169 N NMe Q1v a bond Me a bond NH S NH Q3a OH
    170 N NMe Q1v a bond Me a bond NH S NH Q3b OH
    171 N NMe Q1v a bond Me a bond NH S NH Q3c OH
    172 N NMe Q1v a bond Me a bond NH S a bond Q3a OH
    173 N NMe Q1v a bond Me a bond NH S a bond Q3b OH
    174 N NMe Q1v a bond Me a bond NH S a bond Q3c OH
    175 N NMe Q1v a bond Me a bond NH O NH Q3a OH
    176 N NMe Q1v a bond Me a bond NH O NH Q3b OH
    177 N NMe Q1v a bond Me a bond NH O NH Q3c OH
    178 N NMe Q1v a bond Me a bond NH O a bond Q3a OH
    179 N NMe Q1v a bond Me a bond NH O a bond Q3b OH
    180 N NMe Q1v a bond Me a bond NH O a bond Q3c OH
    181 N NMe Q1v a bond H a bond NH S NH Q3a OH
    182 N NMe Q1v a bond H a bond NH S NH Q3b OH
    183 N NMe Q1v a bond H a bond NH S NH Q3c OH
    184 N NMe Q1v a bond H a bond NH S a bond Q3a OH
    185 N NMe Q1v a bond H a bond NH S a bond Q3b OH
    186 N NMe Q1v a bond H a bond NH S a bond Q3c OH
    187 N NMe Q1v a bond H a bond NH O NH Q3a OH
    188 N NMe Q1v a bond H a bond NH O NH Q3b OH
    189 N NMe Q1v a bond H a bond NH O NH Q3c OH
    190 N NMe Q1v a bond H a bond NH O a bond Q3a OH
    191 N NMe Q1v a bond H a bond NH O a bond Q3b OH
    192 N NMe Q1v a bond H a bond NH O a bond Q3c OH
    193 N NMe Q1w a bond Me a bond NH S NH Q3a OH
    194 N NMe Q1w a bond Me a bond NH S NH Q3b OH
    195 N NMe Q1w a bond Me a bond NH S NH Q3c OH
    196 N NMe Q1w a bond Me a bond NH S a bond Q3a OH
    197 N NMe Q1w a bond Me a bond NH S a bond Q3b OH
    198 N NMe Q1w a bond Me a bond NH S a bond Q3c OH
    199 N NMe Q1w a bond Me a bond NH O NH Q3a OH
    200 N NMe Q1w a bond Me a bond NH O NH Q3b OH
    201 N NMe Q1w a bond Me a bond NH O NH Q3c OH
    202 N NMe Q1w a bond Me a bond NH O a bond Q3a OH
    203 N NMe Q1w a bond Me a bond NH O a bond Q3b OH
    204 N NMe Q1w a bond Me a bond NH O a bond Q3c OH
    205 N NMe Q1w a bond H a bond NH S NH Q3a OH
    206 N NMe Q1w a bond H a bond NH S NH Q3b OH
    207 N NMe Q1w a bond H a bond NH S NH Q3c OH
    208 N NMe Q1w a bond H a bond NH S a bond Q3a OH
    209 N NMe Q1w a bond H a bond NH S a bond Q3b OH
    210 N NMe Q1w a bond H a bond NH S a bond Q3c OH
    211 N NMe Q1w a bond H a bond NH O NH Q3a OH
    212 N NMe Q1w a bond H a bond NH O NH Q3b OH
    213 N NMe Q1w a bond H a bond NH O NH Q3c OH
    214 N NMe Q1w a bond H a bond NH O a bond Q3a OH
    215 N NMe Q1w a bond H a bond NH O a bond Q3b OH
    216 N NMe Q1w a bond H a bond NH O a bond Q3c OH
    217 N NMe Q1x a bond Me a bond NH S NH Q3a OH
    218 N NMe Q1x a bond Me a bond NH S NH Q3b OH
    219 N NMe Q1x a bond Me a bond NH S NH Q3c OH
    220 N NMe Q1x a bond Me a bond NH S a bond Q3a OH
    221 N NMe Q1x a bond Me a bond NH S a bond Q3b OH
    222 N NMe Q1x a bond Me a bond NH S a bond Q3c OH
    223 N NMe Q1x a bond Me a bond NH O NH Q3a OH
    224 N NMe Q1x a bond Me a bond NH O NH Q3b OH
    225 N NMe Q1x a bond Me a bond NH O NH Q3c OH
    226 N NMe Q1x a bond Me a bond NH O a bond Q3a OH
    227 N NMe Q1x a bond Me a bond NH O a bond Q3b OH
    228 N NMe Q1x a bond Me a bond NH O a bond Q3c OH
    229 N NMe Q1x a bond H a bond NH S NH Q3a OH
    230 N NMe Q1x a bond H a bond NH S NH Q3b OH
    231 N NMe Q1x a bond H a bond NH S NH Q3c OH
    232 N NMe Q1x a bond H a bond NH S a bond Q3a OH
    233 N NMe Q1x a bond H a bond NH S a bond Q3b OH
    234 N NMe Q1x a bond H a bond NH S a bond Q3c OH
    235 N NMe Q1x a bond H a bond NH O NH Q3a OH
    236 N NMe Q1x a bond H a bond NH O NH Q3b OH
    237 N NMe Q1x a bond H a bond NH O NH Q3c OH
    238 N NMe Q1x a bond H a bond NH O a bond Q3a OH
    239 N NMe Q1x a bond H a bond NH O a bond Q3b OH
    240 N NMe Q1x a bond H a bond NH O a bond Q3c OH
    241 N NEt Q1o a bond Me a bond NH S NH Q3a OH
    242 N NEt Q1o a bond Me a bond NH S NH Q3b OH
    243 N NEt Q1o a bond Me a bond NH S NH Q3c OH
    244 N NEt Q1o a bond Me a bond NH S a bond Q3a OH
    245 N NEt Q1o a bond Me a bond NH S a bond Q3b OH
    246 N NEt Q1o a bond Me a bond NH S a bond Q3c OH
    247 N NEt Q1o a bond Me a bond NH O NH Q3a OH
    248 N NEt Q1o a bond Me a bond NH O NH Q3b OH
    249 N NEt Q1o a bond Me a bond NH O NH Q3c OH
    250 N NEt Q1o a bond Me a bond NH O a bond Q3a OH
    251 N NEt Q1o a bond Me a bond NH O a bond Q3b OH
    252 N NEt Q1o a bond Me a bond NH O a bond Q3c OH
    253 N NEt Q1o a bond H a bond NH S NH Q3a OH
    254 N NEt Q1o a bond H a bond NH S NH Q3b OH
    255 N NEt Q1o a bond H a bond NH S NH Q3c OH
    256 N NEt Q1o a bond H a bond NH S a bond Q3a OH
    257 N NEt Q1o a bond H a bond NH S a bond Q3b OH
    258 N NEt Q1o a bond H a bond NH S a bond Q3c OH
    259 N NEt Q1o a bond H a bond NH O NH Q3a OH
    260 N NEt Q1o a bond H a bond NH O NH Q3b OH
    261 N NEt Q1o a bond H a bond NH O NH Q3c OH
    262 N NEt Q1o a bond H a bond NH O a bond Q3a OH
    263 N NEt Q1o a bond H a bond NH O a bond Q3b OH
    264 N NEt Q1o a bond H a bond NH O a bond Q3c OH
    265 N NEt Q1p a bond Me a bond NH S NH Q3a OH
    266 N NEt Q1p a bond Me a bond NH S NH Q3b OH
    267 N NEt Q1p a bond Me a bond NH S NH Q3c OH
    268 N NEt Q1p a bond Me a bond NH S a bond Q3a OH
    269 N NEt Q1p a bond Me a bond NH S a bond Q3b OH
    270 N NEt Q1p a bond Me a bond NH S a bond Q3c OH
    271 N NEt Q1p a bond Me a bond NH O NH Q3a OH
    272 N NEt Q1p a bond Me a bond NH O NH Q3b OH
    273 N NEt Q1p a bond Me a bond NH O NH Q3c OH
    274 N NEt Q1p a bond Me a bond NH O a bond Q3a OH
    275 N NEt Q1p a bond Me a bond NH O a bond Q3b OH
    276 N NEt Q1p a bond Me a bond NH O a bond Q3c OH
    277 N NEt Q1p a bond H a bond NH S NH Q3a OH
    278 N NEt Q1p a bond H a bond NH S NH Q3b OH
    279 N NEt Q1p a bond H a bond NH S NH Q3c OH
    280 N NEt Q1p a bond H a bond NH S a bond Q3a OH
    281 N NEt Q1p a bond H a bond NH S a bond Q3b OH
    282 N NEt Q1p a bond H a bond NH S a bond Q3c OH
    283 N NEt Q1p a bond H a bond NH O NH Q3a OH
    284 N NEt Q1p a bond H a bond NH O NH Q3b OH
    285 N NEt Q1p a bond H a bond NH O NH Q3c OH
    286 N NEt Q1p a bond H a bond NH O a bond Q3a OH
    287 N NEt Q1p a bond H a bond NH O a bond Q3b OH
    288 N NEt Q1p a bond H a bond NH O a bond Q3c OH
    289 N NEt Q1q a bond Me a bond NH S NH Q3a OH
    290 N NEt Q1q a bond Me a bond NH S NH Q3b OH
    291 N NEt Q1q a bond Me a bond NH S NH Q3c OH
    292 N NEt Q1q a bond Me a bond NH S a bond Q3a OH
    293 N NEt Q1q a bond Me a bond NH S a bond Q3b OH
    294 N NEt Q1q a bond Me a bond NH S a bond Q3c OH
    295 N NEt Q1q a bond Me a bond NH O NH Q3a OH
    296 N NEt Q1q a bond Me a bond NH O NH Q3b OH
    297 N NEt Q1q a bond Me a bond NH O NH Q3c OH
    298 N NEt Q1q a bond Me a bond NH O a bond Q3a OH
    299 N NEt Q1q a bond Me a bond NH O a bond Q3b OH
    300 N NEt Q1q a bond Me a bond NH O a bond Q3c OH
    301 N NEt Q1q a bond H a bond NH S NH Q3a OH
    302 N NEt Q1q a bond H a bond NH S NH Q3b OH
    303 N NEt Q1q a bond H a bond NH S NH Q3c OH
    304 N NEt Q1q a bond H a bond NH S a bond Q3a OH
    305 N NEt Q1q a bond H a bond NH S a bond Q3b OH
    306 N NEt Q1q a bond H a bond NH S a bond Q3c OH
    307 N NEt Q1q a bond H a bond NH O NH Q3a OH
    308 N NEt Q1q a bond H a bond NH O NH Q3b OH
    309 N NEt Q1q a bond H a bond NH O NH Q3c OH
    310 N NEt Q1q a bond H a bond NH O a bond Q3a OH
    311 N NEt Q1q a bond H a bond NH O a bond Q3b OH
    312 N NEt Q1q a bond H a bond NH O a bond Q3c OH
    313 N NEt Q1r a bond Me a bond NH S NH Q3a OH
    314 N NEt Q1r a bond Me a bond NH S NH Q3b OH
    315 N NEt Q1r a bond Me a bond NH S NH Q3c OH
    316 N NEt Q1r a bond Me a bond NH S a bond Q3a OH
    317 N NEt Q1r a bond Me a bond NH S a bond Q3b OH
    318 N NEt Q1r a bond Me a bond NH S a bond Q3c OH
    319 N NEt Q1r a bond Me a bond NH O NH Q3a OH
    320 N NEt Q1r a bond Me a bond NH O NH Q3b OH
    321 N NEt Q1r a bond Me a bond NH O NH Q3c OH
    322 N NEt Q1r a bond Me a bond NH O a bond Q3a OH
    323 N NEt Q1r a bond Me a bond NH O a bond Q3b OH
    324 N NEt Q1r a bond Me a bond NH O a bond Q3c OH
    325 N NEt Q1r a bond H a bond NH S NH Q3a OH
    326 N NEt Q1r a bond H a bond NH S NH Q3b OH
    327 N NEt Q1r a bond H a bond NH S NH Q3c OH
    328 N NEt Q1r a bond H a bond NH S a bond Q3a OH
    329 N NEt Q1r a bond H a bond NH S a bond Q3b OH
    330 N NEt Q1r a bond H a bond NH S a bond Q3c OH
    331 N NEt Q1r a bond H a bond NH O NH Q3a OH
    332 N NEt Q1r a bond H a bond NH O NH Q3b OH
    333 N NEt Q1r a bond H a bond NH O NH Q3c OH
    334 N NEt Q1r a bond H a bond NH O a bond Q3a OH
    335 N NEt Q1r a bond H a bond NH O a bond Q3b OH
    336 N NEt Q1r a bond H a bond NH O a bond Q3c OH
    337 N NEt Q1s a bond Me a bond NH S NH Q3a OH
    338 N NEt Q1s a bond Me a bond NH S NH Q3b OH
    339 N NEt Q1s a bond Me a bond NH S NH Q3c OH
    340 N NEt Q1s a bond Me a bond NH S a bond Q3a OH
    341 N NEt Q1s a bond Me a bond NH S a bond Q3b OH
    342 N NEt Q1s a bond Me a bond NH S a bond Q3c OH
    343 N NEt Q1s a bond Me a bond NH O NH Q3a OH
    344 N NEt Q1s a bond Me a bond NH O NH Q3b OH
    345 N NEt Q1s a bond Me a bond NH O NH Q3c OH
    346 N NEt Q1s a bond Me a bond NH O a bond Q3a OH
    347 N NEt Q1s a bond Me a bond NH O a bond Q3b OH
    348 N NEt Q1s a bond Me a bond NH O a bond Q3c OH
    349 N NEt Q1s a bond H a bond NH S NH Q3a OH
    350 N NEt Q1s a bond H a bond NH S NH Q3b OH
    351 N NEt Q1s a bond H a bond NH S NH Q3c OH
    352 N NEt Q1s a bond H a bond NH S a bond Q3a OH
    353 N NEt Q1s a bond H a bond NH S a bond Q3b OH
    354 N NEt Q1s a bond H a bond NH S a bond Q3c OH
    355 N NEt Q1s a bond H a bond NH O NH Q3a OH
    356 N NEt Q1s a bond H a bond NH O NH Q3b OH
    357 N NEt Q1s a bond H a bond NH O NH Q3c OH
    358 N NEt Q1s a bond H a bond NH O a bond Q3a OH
    359 N NEt Q1s a bond H a bond NH O a bond Q3b OH
    360 N NEt Q1s a bond H a bond NH O a bond Q3c OH
    361 N NEt Q1t a bond Me a bond NH S NH Q3a OH
    362 N NEt Q1t a bond Me a bond NH S NH Q3b OH
    363 N NEt Q1t a bond Me a bond NH S NH Q3c OH
    364 N NEt Q1t a bond Me a bond NH S a bond Q3a OH
    365 N NEt Q1t a bond Me a bond NH S a bond Q3b OH
    366 N NEt Q1t a bond Me a bond NH S a bond Q3c OH
    367 N NEt Q1t a bond Me a bond NH O NH Q3a OH
    368 N NEt Q1t a bond Me a bond NH O NH Q3b OH
    369 N NEt Q1t a bond Me a bond NH O NH Q3c OH
    370 N NEt Q1t a bond Me a bond NH O a bond Q3a OH
    371 N NEt Q1t a bond Me a bond NH O a bond Q3b OH
    372 N NEt Q1t a bond Me a bond NH O a bond Q3c OH
    373 N NEt Q1t a bond H a bond NH S NH Q3a OH
    374 N NEt Q1t a bond H a bond NH S NH Q3b OH
    375 N NEt Q1t a bond H a bond NH S NH Q3c OH
    376 N NEt Q1t a bond H a bond NH S a bond Q3a OH
    377 N NEt Q1t a bond H a bond NH S a bond Q3b OH
    378 N NEt Q1t a bond H a bond NH S a bond Q3c OH
    379 N NEt Q1t a bond H a bond NH O NH Q3a OH
    380 N NEt Q1t a bond H a bond NH O NH Q3b OH
    381 N NEt Q1t a bond H a bond NH O NH Q3c OH
    382 N NEt Q1t a bond H a bond NH O a bond Q3a OH
    383 N NEt Q1t a bond H a bond NH O a bond Q3b OH
    384 N NEt Q1t a bond H a bond NH O a bond Q3c OH
    385 N NEt Q1u a bond Me a bond NH S NH Q3a OH
    386 N NEt Q1u a bond Me a bond NH S NH Q3b OH
    387 N NEt Q1u a bond Me a bond NH S NH Q3c OH
    388 N NEt Q1u a bond Me a bond NH S a bond Q3a OH
    389 N NEt Q1u a bond Me a bond NH S a bond Q3b OH
    390 N NEt Q1u a bond Me a bond NH S a bond Q3c OH
    391 N NEt Q1u a bond Me a bond NH O NH Q3a OH
    392 N NEt Q1u a bond Me a bond NH O NH Q3b OH
    393 N NEt Q1u a bond Me a bond NH O NH Q3c OH
    394 N NEt Q1u a bond Me a bond NH O a bond Q3a OH
    395 N NEt Q1u a bond Me a bond NH O a bond Q3b OH
    396 N NEt Q1u a bond Me a bond NH O a bond Q3c OH
    397 N NEt Q1u a bond H a bond NH S NH Q3a OH
    398 N NEt Q1u a bond H a bond NH S NH Q3b OH
    399 N NEt Q1u a bond H a bond NH S NH Q3c OH
    400 N NEt Q1u a bond H a bond NH S a bond Q3a OH
    401 N NEt Q1u a bond H a bond NH S a bond Q3b OH
    402 N NEt Q1u a bond H a bond NH S a bond Q3c OH
    403 N NEt Q1u a bond H a bond NH O NH Q3a OH
    404 N NEt Q1u a bond H a bond NH O NH Q3b OH
    405 N NEt Q1u a bond H a bond NH O NH Q3c OH
    406 N NEt Q1u a bond H a bond NH O a bond Q3a OH
    407 N NEt Q1u a bond H a bond NH O a bond Q3b OH
    408 N NEt Q1u a bond H a bond NH O a bond Q3c OH
    409 N NEt Q1v a bond Me a bond NH S NH Q3a OH
    410 N NEt Q1v a bond Me a bond NH S NH Q3b OH
    411 N NEt Q1v a bond Me a bond NH S NH Q3c OH
    412 N NEt Q1v a bond Me a bond NH S a bond Q3a OH
    413 N NEt Q1v a bond Me a bond NH S a bond Q3b OH
    414 N NEt Q1v a bond Me a bond NH S a bond Q3c OH
    415 N NEt Q1v a bond Me a bond NH O NH Q3a OH
    416 N NEt Q1v a bond Me a bond NH O NH Q3b OH
    417 N NEt Q1v a bond Me a bond NH O NH Q3c OH
    418 N NEt Q1v a bond Me a bond NH O a bond Q3a OH
    419 N NEt Q1v a bond Me a bond NH O a bond Q3b OH
    420 N NEt Q1v a bond Me a bond NH O a bond Q3c OH
    421 N NEt Q1v a bond H a bond NH S NH Q3a OH
    422 N NEt Q1v a bond H a bond NH S NH Q3b OH
    423 N NEt Q1v a bond H a bond NH S NH Q3c OH
    424 N NEt Q1v a bond H a bond NH S a bond Q3a OH
    425 N NEt Q1v a bond H a bond NH S a bond Q3b OH
    426 N NEt Q1v a bond H a bond NH S a bond Q3c OH
    427 N NEt Q1v a bond H a bond NH O NH Q3a OH
    428 N NEt Q1v a bond H a bond NH O NH Q3b OH
    429 N NEt Q1v a bond H a bond NH O NH Q3c OH
    430 N NEt Q1v a bond H a bond NH O a bond Q3a OH
    431 N NEt Q1v a bond H a bond NH O a bond Q3b OH
    432 N NEt Q1v a bond H a bond NH O a bond Q3c OH
    433 N NEt Q1w a bond Me a bond NH S NH Q3a OH
    434 N NEt Q1w a bond Me a bond NH S NH Q3b OH
    435 N NEt Q1w a bond Me a bond NH S NH Q3c OH
    436 N NEt Q1w a bond Me a bond NH S a bond Q3a OH
    437 N NEt Q1w a bond Me a bond NH S a bond Q3b OH
    438 N NEt Q1w a bond Me a bond NH S a bond Q3c OH
    439 N NEt Q1w a bond Me a bond NH O NH Q3a OH
    440 N NEt Q1w a bond Me a bond NH O NH Q3b OH
    441 N NEt Q1w a bond Me a bond NH O NH Q3c OH
    442 N NEt Q1w a bond Me a bond NH O a bond Q3a OH
    443 N NEt Q1w a bond Me a bond NH O a bond Q3b OH
    444 N NEt Q1w a bond Me a bond NH O a bond Q3c OH
    445 N NEt Q1w a bond H a bond NH S NH Q3a OH
    446 N NEt Q1w a bond H a bond NH S NH Q3b OH
    447 N NEt Q1w a bond H a bond NH S NH Q3c OH
    448 N NEt Q1w a bond H a bond NH S a bond Q3a OH
    449 N NEt Q1w a bond H a bond NH S a bond Q3b OH
    450 N NEt Q1w a bond H a bond NH S a bond Q3c OH
    451 N NEt Q1w a bond H a bond NH O NH Q3a OH
    452 N NEt Q1w a bond H a bond NH O NH Q3b OH
    453 N NEt Q1w a bond H a bond NH O NH Q3c OH
    454 N NEt Q1w a bond H a bond NH O a bond Q3a OH
    455 N NEt Q1w a bond H a bond NH O a bond Q3b OH
    456 N NEt Q1w a bond H a bond NH O a bond Q3c OH
    457 N NEt Q1x a bond Me a bond NH S NH Q3a OH
    458 N NEt Q1x a bond Me a bond NH S NH Q3b OH
    459 N NEt Q1x a bond Me a bond NH S NH Q3c OH
    460 N NEt Q1x a bond Me a bond NH S a bond Q3a OH
    461 N NEt Q1x a bond Me a bond NH S a bond Q3b OH
    462 N NEt Q1x a bond Me a bond NH S a bond Q3c OH
    463 N NEt Q1x a bond Me a bond NH O NH Q3a OH
    464 N NEt Q1x a bond Me a bond NH O NH Q3b OH
    465 N NEt Q1x a bond Me a bond NH O NH Q3c OH
    466 N NEt Q1x a bond Me a bond NH O a bond Q3a OH
    467 N NEt Q1x a bond Me a bond NH O a bond Q3b OH
    468 N NEt Q1x a bond Me a bond NH O a bond Q3c OH
    469 N NEt Q1x a bond H a bond NH S NH Q3a OH
    470 N NEt Q1x a bond H a bond NH S NH Q3b OH
    471 N NEt Q1x a bond H a bond NH S NH Q3c OH
    472 N NEt Q1x a bond H a bond NH S a bond Q3a OH
    473 N NEt Q1x a bond H a bond NH S a bond Q3b OH
    474 N NEt Q1x a bond H a bond NH S a bond Q3c OH
    475 N NEt Q1x a bond H a bond NH O NH Q3a OH
    476 N NEt Q1x a bond H a bond NH O NH Q3b OH
    477 N NEt Q1x a bond H a bond NH O NH Q3c OH
    478 N NEt Q1x a bond H a bond NH O a bond Q3a OH
    479 N NEt Q1x a bond H a bond NH O a bond Q3b OH
    480 N NEt Q1x a bond H a bond NH O a bond Q3c OH
    481 N S Q1o a bond Me a bond NH S NH Q3a OH
    482 N S Q1o a bond Me a bond NH S NH Q3b OH
    483 N S Q1o a bond Me a bond NH S NH Q3c OH
    484 N S Q1o a bond Me a bond NH S a bond Q3a OH
    485 N S Q1o a bond Me a bond NH S a bond Q3b OH
    486 N S Q1o a bond Me a bond NH S a bond Q3c OH
    487 N S Q1o a bond Me a bond NH O NH Q3a OH
    488 N S Q1o a bond Me a bond NH O NH Q3b OH
    489 N S Q1o a bond Me a bond NH O NH Q3c OH
    490 N S Q1o a bond Me a bond NH O a bond Q3a OH
    491 N S Q1o a bond Me a bond NH O a bond Q3b OH
    492 N S Q1o a bond Me a bond NH O a bond Q3c OH
    493 N S Q1o a bond H a bond NH S NH Q3a OH
    494 N S Q1o a bond H a bond NH S NH Q3b OH
    495 N S Q1o a bond H a bond NH S NH Q3c OH
    496 N S Q1o a bond H a bond NH S a bond Q3a OH
    497 N S Q1o a bond H a bond NH S a bond Q3b OH
    498 N S Q1o a bond H a bond NH S a bond Q3c OH
    499 N S Q1o a bond H a bond NH O NH Q3a OH
    500 N S Q1o a bond H a bond NH O NH Q3b OH
    501 N S Q1o a bond H a bond NH O NH Q3c OH
    502 N S Q1o a bond H a bond NH O a bond Q3a OH
    503 N S Q1o a bond H a bond NH O a bond Q3b OH
    504 N S Q1o a bond H a bond NH O a bond Q3c OH
    505 N S Q1p a bond Me a bond NH S NH Q3a OH
    506 N S Q1p a bond Me a bond NH S NH Q3b OH
    507 N S Q1p a bond Me a bond NH S NH Q3c OH
    508 N S Q1p a bond Me a bond NH S a bond Q3a OH
    509 N S Q1p a bond Me a bond NH S a bond Q3b OH
    510 N S Q1p a bond Me a bond NH S a bond Q3c OH
    511 N S Q1p a bond Me a bond NH O NH Q3a OH
    512 N S Q1p a bond Me a bond NH O NH Q3b OH
    513 N S Q1p a bond Me a bond NH O NH Q3c OH
    514 N S Q1p a bond Me a bond NH O a bond Q3a OH
    515 N S Q1p a bond Me a bond NH O a bond Q3b OH
    516 N S Q1p a bond Me a bond NH O a bond Q3c OH
    517 N S Q1p a bond H a bond NH S NH Q3a OH
    518 N S Q1p a bond H a bond NH S NH Q3b OH
    519 N S Q1p a bond H a bond NH S NH Q3c OH
    520 N S Q1p a bond H a bond NH S a bond Q3a OH
    521 N S Q1p a bond H a bond NH S a bond Q3b OH
    522 N S Q1p a bond H a bond NH S a bond Q3c OH
    523 N S Q1p a bond H a bond NH O NH Q3a OH
    524 N S Q1p a bond H a bond NH O NH Q3b OH
    525 N S Q1p a bond H a bond NH O NH Q3c OH
    526 N S Q1p a bond H a bond NH O a bond Q3a OH
    527 N S Q1p a bond H a bond NH O a bond Q3b OH
    528 N S Q1p a bond H a bond NH O a bond Q3c OH
    529 N S Q1q a bond Me a bond NH S NH Q3a OH
    530 N S Q1q a bond Me a bond NH S NH Q3b OH
    531 N S Q1q a bond Me a bond NH S NH Q3c OH
    532 N S Q1q a bond Me a bond NH S a bond Q3a OH
    533 N S Q1q a bond Me a bond NH S a bond Q3b OH
    534 N S Q1q a bond Me a bond NH S a bond Q3c OH
    535 N S Q1q a bond Me a bond NH O NH Q3a OH
    536 N S Q1q a bond Me a bond NH O NH Q3b OH
    537 N S Q1q a bond Me a bond NH O NH Q3c OH
    538 N S Q1q a bond Me a bond NH O a bond Q3a OH
    539 N S Q1q a bond Me a bond NH O a bond Q3b OH
    540 N S Q1q a bond Me a bond NH O a bond Q3c OH
    541 N S Q1q a bond H a bond NH S NH Q3a OH
    542 N S Q1q a bond H a bond NH S NH Q3b OH
    543 N S Q1q a bond H a bond NH S NH Q3c OH
    544 N S Q1q a bond H a bond NH S a bond Q3a OH
    545 N S Q1q a bond H a bond NH S a bond Q3b OH
    546 N S Q1q a bond H a bond NH S a bond Q3c OH
    547 N S Q1q a bond H a bond NH O NH Q3a OH
    548 N S Q1q a bond H a bond NH O NH Q3b OH
    549 N S Q1q a bond H a bond NH O NH Q3c OH
    550 N S Q1q a bond H a bond NH O a bond Q3a OH
    551 N S Q1q a bond H a bond NH O a bond Q3b OH
    552 N S Q1q a bond H a bond NH O a bond Q3c OH
    553 N S Q1r a bond Me a bond NH S NH Q3a OH
    554 N S Q1r a bond Me a bond NH S NH Q3b OH
    555 N S Q1r a bond Me a bond NH S NH Q3c OH
    556 N S Q1r a bond Me a bond NH S a bond Q3a OH
    557 N S Q1r a bond Me a bond NH S a bond Q3b OH
    558 N S Q1r a bond Me a bond NH S a bond Q3c OH
    559 N S Q1r a bond Me a bond NH O NH Q3a OH
    560 N S Q1r a bond Me a bond NH O NH Q3b OH
    561 N S Q1r a bond Me a bond NH O NH Q3c OH
    562 N S Q1r a bond Me a bond NH O a bond Q3a OH
    563 N S Q1r a bond Me a bond NH O a bond Q3b OH
    564 N S Q1r a bond Me a bond NH O a bond Q3c OH
    565 N S Q1r a bond H a bond NH S NH Q3a OH
    566 N S Q1r a bond H a bond NH S NH Q3b OH
    567 N S Q1r a bond H a bond NH S NH Q3c OH
    568 N S Q1r a bond H a bond NH S a bond Q3a OH
    569 N S Q1r a bond H a bond NH S a bond Q3b OH
    570 N S Q1r a bond H a bond NH S a bond Q3c OH
    571 N S Q1r a bond H a bond NH O NH Q3a OH
    572 N S Q1r a bond H a bond NH O NH Q3b OH
    573 N S Q1r a bond H a bond NH O NH Q3c OH
    574 N S Q1r a bond H a bond NH O a bond Q3a OH
    575 N S Q1r a bond H a bond NH O a bond Q3b OH
    576 N S Q1r a bond H a bond NH O a bond Q3c OH
    577 N S Q1s a bond Me a bond NH S NH Q3a OH
    578 N S Q1s a bond Me a bond NH S NH Q3b OH
    579 N S Q1s a bond Me a bond NH S NH Q3c OH
    580 N S Q1s a bond Me a bond NH S a bond Q3a OH
    581 N S Q1s a bond Me a bond NH S a bond Q3b OH
    582 N S Q1s a bond Me a bond NH S a bond Q3c OH
    583 N S Q1s a bond Me a bond NH O NH Q3a OH
    584 N S Q1s a bond Me a bond NH O NH Q3b OH
    585 N S Q1s a bond Me a bond NH O NH Q3c OH
    586 N S Q1s a bond Me a bond NH O a bond Q3a OH
    587 N S Q1s a bond Me a bond NH O a bond Q3b OH
    588 N S Q1s a bond Me a bond NH O a bond Q3c OH
    589 N S Q1s a bond H a bond NH S NH Q3a OH
    590 N S Q1s a bond H a bond NH S NH Q3b OH
    591 N S Q1s a bond H a bond NH S NH Q3c OH
    592 N S Q1s a bond H a bond NH S a bond Q3a OH
    593 N S Q1s a bond H a bond NH S a bond Q3b OH
    594 N S Q1s a bond H a bond NH S a bond Q3c OH
    595 N S Q1s a bond H a bond NH O NH Q3a OH
    596 N S Q1s a bond H a bond NH O NH Q3b OH
    597 N S Q1s a bond H a bond NH O NH Q3c OH
    598 N S Q1s a bond H a bond NH O a bond Q3a OH
    599 N S Q1s a bond H a bond NH O a bond Q3b OH
    600 N S Q1s a bond H a bond NH O a bond Q3c OH
    601 N S Q1t a bond Me a bond NH S NH Q3a OH
    602 N S Q1t a bond Me a bond NH S NH Q3b OH
    603 N S Q1t a bond Me a bond NH S NH Q3c OH
    604 N S Q1t a bond Me a bond NH S a bond Q3a OH
    605 N S Q1t a bond Me a bond NH S a bond Q3b OH
    606 N S Q1t a bond Me a bond NH S a bond Q3c OH
    607 N S Q1t a bond Me a bond NH O NH Q3a OH
    608 N S Q1t a bond Me a bond NH O NH Q3b OH
    609 N S Q1t a bond Me a bond NH O NH Q3c OH
    610 N S Q1t a bond Me a bond NH O a bond Q3a OH
    611 N S Q1t a bond Me a bond NH O a bond Q3b OH
    612 N S Q1t a bond Me a bond NH O a bond Q3c OH
    613 N S Q1t a bond H a bond NH S NH Q3a OH
    614 N S Q1t a bond H a bond NH S NH Q3b OH
    615 N S Q1t a bond H a bond NH S NH Q3c OH
    616 N S Q1t a bond H a bond NH S a bond Q3a OH
    617 N S Q1t a bond H a bond NH S a bond Q3b OH
    618 N S Q1t a bond H a bond NH S a bond Q3c OH
    619 N S Q1t a bond H a bond NH O NH Q3a OH
    620 N S Q1t a bond H a bond NH O NH Q3b OH
    621 N S Q1t a bond H a bond NH O NH Q3c OH
    622 N S Q1t a bond H a bond NH O a bond Q3a OH
    623 N S Q1t a bond H a bond NH O a bond Q3b OH
    624 N S Q1t a bond H a bond NH O a bond Q3c OH
    625 N S Q1u a bond Me a bond NH S NH Q3a OH
    626 N S Q1u a bond Me a bond NH S NH Q3b OH
    627 N S Q1u a bond Me a bond NH S NH Q3c OH
    628 N S Q1u a bond Me a bond NH S a bond Q3a OH
    629 N S Q1u a bond Me a bond NH S a bond Q3b OH
    630 N S Q1u a bond Me a bond NH S a bond Q3c OH
    631 N S Q1u a bond Me a bond NH O NH Q3a OH
    632 N S Q1u a bond Me a bond NH O NH Q3b OH
    633 N S Q1u a bond Me a bond NH O NH Q3c OH
    634 N S Q1u a bond Me a bond NH O a bond Q3a OH
    635 N S Q1u a bond Me a bond NH O a bond Q3b OH
    636 N S Q1u a bond Me a bond NH O a bond Q3c OH
    637 N S Q1u a bond H a bond NH S NH Q3a OH
    638 N S Q1u a bond H a bond NH S NH Q3b OH
    639 N S Q1u a bond H a bond NH S NH Q3c OH
    640 N S Q1u a bond H a bond NH S a bond Q3a OH
    641 N S Q1u a bond H a bond NH S a bond Q3b OH
    642 N S Q1u a bond H a bond NH S a bond Q3c OH
    643 N S Q1u a bond H a bond NH O NH Q3a OH
    644 N S Q1u a bond H a bond NH O NH Q3b OH
    645 N S Q1u a bond H a bond NH O NH Q3c OH
    646 N S Q1u a bond H a bond NH O a bond Q3a OH
    647 N S Q1u a bond H a bond NH O a bond Q3b OH
    648 N S Q1u a bond H a bond NH O a bond Q3c OH
    649 N S Q1v a bond Me a bond NH S NH Q3a OH
    650 N S Q1v a bond Me a bond NH S NH Q3b OH
    651 N S Q1v a bond Me a bond NH S NH Q3c OH
    652 N S Q1v a bond Me a bond NH S a bond Q3a OH
    653 N S Q1v a bond Me a bond NH S a bond Q3b OH
    654 N S Q1v a bond Me a bond NH S a bond Q3c OH
    655 N S Q1v a bond Me a bond NH O NH Q3a OH
    656 N S Q1v a bond Me a bond NH O NH Q3b OH
    657 N S Q1v a bond Me a bond NH O NH Q3c OH
    658 N S Q1v a bond Me a bond NH O a bond Q3a OH
    659 N S Q1v a bond Me a bond NH O a bond Q3b OH
    660 N S Q1v a bond Me a bond NH O a bond Q3c OH
    661 N S Q1v a bond H a bond NH S NH Q3a OH
    662 N S Q1v a bond H a bond NH S NH Q3b OH
    663 N S Q1v a bond H a bond NH S NH Q3c OH
    664 N S Q1v a bond H a bond NH S a bond Q3a OH
    665 N S Q1v a bond H a bond NH S a bond Q3b OH
    666 N S Q1v a bond H a bond NH S a bond Q3c OH
    667 N S Q1v a bond H a bond NH O NH Q3a OH
    668 N S Q1v a bond H a bond NH O NH Q3b OH
    669 N S Q1v a bond H a bond NH O NH Q3c OH
    670 N S Q1v a bond H a bond NH O a bond Q3a OH
    671 N S Q1v a bond H a bond NH O a bond Q3b OH
    672 N S Q1v a bond H a bond NH O a bond Q3c OH
    673 N S Q1w a bond Me a bond NH S NH Q3a OH
    674 N S Q1w a bond Me a bond NH S NH Q3b OH
    675 N S Q1w a bond Me a bond NH S NH Q3c OH
    676 N S Q1w a bond Me a bond NH S a bond Q3a OH
    677 N S Q1w a bond Me a bond NH S a bond Q3b OH
    678 N S Q1w a bond Me a bond NH S a bond Q3c OH
    679 N S Q1w a bond Me a bond NH O NH Q3a OH
    680 N S Q1w a bond Me a bond NH O NH Q3b OH
    681 N S Q1w a bond Me a bond NH O NH Q3c OH
    682 N S Q1w a bond Me a bond NH O a bond Q3a OH
    683 N S Q1w a bond Me a bond NH O a bond Q3b OH
    684 N S Q1w a bond Me a bond NH O a bond Q3c OH
    685 N S Q1w a bond H a bond NH S NH Q3a OH
    686 N S Q1w a bond H a bond NH S NH Q3b OH
    687 N S Q1w a bond H a bond NH S NH Q3c OH
    688 N S Q1w a bond H a bond NH S a bond Q3a OH
    689 N S Q1w a bond H a bond NH S a bond Q3b OH
    690 N S Q1w a bond H a bond NH S a bond Q3c OH
    691 N S Q1w a bond H a bond NH O NH Q3a OH
    692 N S Q1w a bond H a bond NH O NH Q3b OH
    693 N S Q1w a bond H a bond NH O NH Q3c OH
    694 N S Q1w a bond H a bond NH O a bond Q3a OH
    695 N S Q1w a bond H a bond NH O a bond Q3b OH
    696 N S Q1w a bond H a bond NH O a bond Q3c OH
    697 N S Q1x a bond Me a bond NH S NH Q3a OH
    698 N S Q1x a bond Me a bond NH S NH Q3b OH
    699 N S Q1x a bond Me a bond NH S NH Q3c OH
    700 N S Q1x a bond Me a bond NH S a bond Q3a OH
    701 N S Q1x a bond Me a bond NH S a bond Q3b OH
    702 N S Q1x a bond Me a bond NH S a bond Q3c OH
    703 N S Q1x a bond Me a bond NH O NH Q3a OH
    704 N S Q1x a bond Me a bond NH O NH Q3b OH
    705 N S Q1x a bond Me a bond NH O NH Q3c OH
    706 N S Q1x a bond Me a bond NH O a bond Q3a OH
    707 N S Q1x a bond Me a bond NH O a bond Q3b OH
    708 N S Q1x a bond Me a bond NH O a bond Q3c OH
    709 N S Q1x a bond H a bond NH S NH Q3a OH
    710 N S Q1x a bond H a bond NH S NH Q3b OH
    711 N S Q1x a bond H a bond NH S NH Q3c OH
    712 N S Q1x a bond H a bond NH S a bond Q3a OH
    713 N S Q1x a bond H a bond NH S a bond Q3b OH
    714 N S Q1x a bond H a bond NH S a bond Q3c OH
    715 N S Q1x a bond H a bond NH O NH Q3a OH
    716 N S Q1x a bond H a bond NH O NH Q3b OH
    717 N S Q1x a bond H a bond NH O NH Q3c OH
    718 N S Q1x a bond H a bond NH O a bond Q3a OH
    719 N S Q1x a bond H a bond NH O a bond Q3b OH
    720 N S Q1x a bond H a bond NH O a bond Q3c OH
    721 N O Q1o a bond Me a bond NH S NH Q3a OH
    722 N O Q1o a bond Me a bond NH S NH Q3b OH
    723 N O Q1o a bond Me a bond NH S NH Q3c OH
    724 N O Q1o a bond Me a bond NH S a bond Q3a OH
    725 N O Q1o a bond Me a bond NH S a bond Q3b OH
    726 N O Q1o a bond Me a bond NH S a bond Q3c OH
    727 N O Q1o a bond Me a bond NH O NH Q3a OH
    728 N O Q1o a bond Me a bond NH O NH Q3b OH
    729 N O Q1o a bond Me a bond NH O NH Q3c OH
    730 N O Q1o a bond Me a bond NH O a bond Q3a OH
    731 N O Q1o a bond Me a bond NH O a bond Q3b OH
    732 N O Q1o a bond Me a bond NH O a bond Q3c OH
    733 N O Q1o a bond H a bond NH S NH Q3a OH
    734 N O Q1o a bond H a bond NH S NH Q3b OH
    735 N O Q1o a bond H a bond NH S NH Q3c OH
    736 N O Q1o a bond H a bond NH S a bond Q3a OH
    737 N O Q1o a bond H a bond NH S a bond Q3b OH
    738 N O Q1o a bond H a bond NH S a bond Q3c OH
    739 N O Q1o a bond H a bond NH O NH Q3a OH
    740 N O Q1o a bond H a bond NH O NH Q3b OH
    741 N O Q1o a bond H a bond NH O NH Q3c OH
    742 N O Q1o a bond H a bond NH O a bond Q3a OH
    743 N O Q1o a bond H a bond NH O a bond Q3b OH
    744 N O Q1o a bond H a bond NH O a bond Q3c OH
    745 N O Q1p a bond Me a bond NH S NH Q3a OH
    746 N O Q1p a bond Me a bond NH S NH Q3b OH
    747 N O Q1p a bond Me a bond NH S NH Q3c OH
    748 N O Q1p a bond Me a bond NH S a bond Q3a OH
    749 N O Q1p a bond Me a bond NH S a bond Q3b OH
    750 N O Q1p a bond Me a bond NH S a bond Q3c OH
    751 N O Q1p a bond Me a bond NH O NH Q3a OH
    752 N O Q1p a bond Me a bond NH O NH Q3b OH
    753 N O Q1p a bond Me a bond NH O NH Q3c OH
    754 N O Q1p a bond Me a bond NH O a bond Q3a OH
    755 N O Q1p a bond Me a bond NH O a bond Q3b OH
    756 N O Q1p a bond Me a bond NH O a bond Q3c OH
    757 N O Q1p a bond H a bond NH S NH Q3a OH
    758 N O Q1p a bond H a bond NH S NH Q3b OH
    759 N O Q1p a bond H a bond NH S NH Q3c OH
    760 N O Q1p a bond H a bond NH S a bond Q3a OH
    761 N O Q1p a bond H a bond NH S a bond Q3b OH
    762 N O Q1p a bond H a bond NH S a bond Q3c OH
    763 N O Q1p a bond H a bond NH O NH Q3a OH
    764 N O Q1p a bond H a bond NH O NH Q3b OH
    765 N O Q1p a bond H a bond NH O NH Q3c OH
    766 N O Q1p a bond H a bond NH O a bond Q3a OH
    767 N O Q1p a bond H a bond NH O a bond Q3b OH
    768 N O Q1p a bond H a bond NH O a bond Q3c OH
    769 N O Q1q a bond Me a bond NH S NH Q3a OH
    770 N O Q1q a bond Me a bond NH S NH Q3b OH
    771 N O Q1q a bond Me a bond NH S NH Q3c OH
    772 N O Q1q a bond Me a bond NH S a bond Q3a OH
    773 N O Q1q a bond Me a bond NH S a bond Q3b OH
    774 N O Q1q a bond Me a bond NH S a bond Q3c OH
    775 N O Q1q a bond Me a bond NH O NH Q3a OH
    776 N O Q1q a bond Me a bond NH O NH Q3b OH
    777 N O Q1q a bond Me a bond NH O NH Q3c OH
    778 N O Q1q a bond Me a bond NH O a bond Q3a OH
    779 N O Q1q a bond Me a bond NH O a bond Q3b OH
    780 N O Q1q a bond Me a bond NH O a bond Q3c OH
    781 N O Q1q a bond H a bond NH S NH Q3a OH
    782 N O Q1q a bond H a bond NH S NH Q3b OH
    783 N O Q1q a bond H a bond NH S NH Q3c OH
    784 N O Q1q a bond H a bond NH S a bond Q3a OH
    785 N O Q1q a bond H a bond NH S a bond Q3b OH
    786 N O Q1q a bond H a bond NH S a bond Q3c OH
    787 N O Q1q a bond H a bond NH O NH Q3a OH
    788 N O Q1q a bond H a bond NH O NH Q3b OH
    789 N O Q1q a bond H a bond NH O NH Q3c OH
    790 N O Q1q a bond H a bond NH O a bond Q3a OH
    791 N O Q1q a bond H a bond NH O a bond Q3b OH
    792 N O Q1q a bond H a bond NH O a bond Q3c OH
    793 N O Q1r a bond Me a bond NH S NH Q3a OH
    794 N O Q1r a bond Me a bond NH S NH Q3b OH
    795 N O Q1r a bond Me a bond NH S NH Q3c OH
    796 N O Q1r a bond Me a bond NH S a bond Q3a OH
    797 N O Q1r a bond Me a bond NH S a bond Q3b OH
    798 N O Q1r a bond Me a bond NH S a bond Q3c OH
    799 N O Q1r a bond Me a bond NH O NH Q3a OH
    800 N O Q1r a bond Me a bond NH O NH Q3b OH
    801 N O Q1r a bond Me a bond NH O NH Q3c OH
    802 N O Q1r a bond Me a bond NH O a bond Q3a OH
    803 N O Q1r a bond Me a bond NH O a bond Q3b OH
    804 N O Q1r a bond Me a bond NH O a bond Q3c OH
    805 N O Q1r a bond H a bond NH S NH Q3a OH
    806 N O Q1r a bond H a bond NH S NH Q3b OH
    807 N O Q1r a bond H a bond NH S NH Q3c OH
    808 N O Q1r a bond H a bond NH S a bond Q3a OH
    809 N O Q1r a bond H a bond NH S a bond Q3b OH
    810 N O Q1r a bond H a bond NH S a bond Q3c OH
    811 N O Q1r a bond H a bond NH O NH Q3a OH
    812 N O Q1r a bond H a bond NH O NH Q3b OH
    813 N O Q1r a bond H a bond NH O NH Q3c OH
    814 N O Q1r a bond H a bond NH O a bond Q3a OH
    815 N O Q1r a bond H a bond NH O a bond Q3b OH
    816 N O Q1r a bond H a bond NH O a bond Q3c OH
    817 N O Q1s a bond Me a bond NH S NH Q3a OH
    818 N O Q1s a bond Me a bond NH S NH Q3b OH
    819 N O Q1s a bond Me a bond NH S NH Q3c OH
    820 N O Q1s a bond Me a bond NH S a bond Q3a OH
    821 N O Q1s a bond Me a bond NH S a bond Q3b OH
    822 N O Q1s a bond Me a bond NH S a bond Q3c OH
    823 N O Q1s a bond Me a bond NH O NH Q3a OH
    824 N O Q1s a bond Me a bond NH O NH Q3b OH
    825 N O Q1s a bond Me a bond NH O NH Q3c OH
    826 N O Q1s a bond Me a bond NH O a bond Q3a OH
    827 N O Q1s a bond Me a bond NH O a bond Q3b OH
    828 N O Q1s a bond Me a bond NH O a bond Q3c OH
    829 N O Q1s a bond H a bond NH S NH Q3a OH
    830 N O Q1s a bond H a bond NH S NH Q3b OH
    831 N O Q1s a bond H a bond NH S NH Q3c OH
    832 N O Q1s a bond H a bond NH S a bond Q3a OH
    833 N O Q1s a bond H a bond NH S a bond Q3b OH
    834 N O Q1s a bond H a bond NH S a bond Q3c OH
    835 N O Q1s a bond H a bond NH O NH Q3a OH
    836 N O Q1s a bond H a bond NH O NH Q3b OH
    837 N O Q1s a bond H a bond NH O NH Q3c OH
    838 N O Q1s a bond H a bond NH O a bond Q3a OH
    839 N O Q1s a bond H a bond NH O a bond Q3b OH
    840 N O Q1s a bond H a bond NH O a bond Q3c OH
    841 N O Q1t a bond Me a bond NH S NH Q3a OH
    842 N O Q1t a bond Me a bond NH S NH Q3b OH
    843 N O Q1t a bond Me a bond NH S NH Q3c OH
    844 N O Q1t a bond Me a bond NH S a bond Q3a OH
    845 N O Q1t a bond Me a bond NH S a bond Q3b OH
    846 N O Q1t a bond Me a bond NH S a bond Q3c OH
    847 N O Q1t a bond Me a bond NH O NH Q3a OH
    848 N O Q1t a bond Me a bond NH O NH Q3b OH
    849 N O Q1t a bond Me a bond NH O NH Q3c OH
    850 N O Q1t a bond Me a bond NH O a bond Q3a OH
    851 N O Q1t a bond Me a bond NH O a bond Q3b OH
    852 N O Q1t a bond Me a bond NH O a bond Q3c OH
    853 N O Q1t a bond H a bond NH S NH Q3a OH
    854 N O Q1t a bond H a bond NH S NH Q3b OH
    855 N O Q1t a bond H a bond NH S NH Q3c OH
    856 N O Q1t a bond H a bond NH S a bond Q3a OH
    857 N O Q1t a bond H a bond NH S a bond Q3b OH
    858 N O Q1t a bond H a bond NH S a bond Q3c OH
    859 N O Q1t a bond H a bond NH O NH Q3a OH
    860 N O Q1t a bond H a bond NH O NH Q3b OH
    861 N O Q1t a bond H a bond NH O NH Q3c OH
    862 N O Q1t a bond H a bond NH O a bond Q3a OH
    863 N O Q1t a bond H a bond NH O a bond Q3b OH
    864 N O Q1t a bond H a bond NH O a bond Q3c OH
    865 N O Q1u a bond Me a bond NH S NH Q3a OH
    866 N O Q1u a bond Me a bond NH S NH Q3b OH
    867 N O Q1u a bond Me a bond NH S NH Q3c OH
    868 N O Q1u a bond Me a bond NH S a bond Q3a OH
    869 N O Q1u a bond Me a bond NH S a bond Q3b OH
    870 N O Q1u a bond Me a bond NH S a bond Q3c OH
    871 N O Q1u a bond Me a bond NH O NH Q3a OH
    872 N O Q1u a bond Me a bond NH O NH Q3b OH
    873 N O Q1u a bond Me a bond NH O NH Q3c OH
    874 N O Q1u a bond Me a bond NH O a bond Q3a OH
    875 N O Q1u a bond Me a bond NH O a bond Q3b OH
    876 N O Q1u a bond Me a bond NH O a bond Q3c OH
    877 N O Q1u a bond H a bond NH S NH Q3a OH
    878 N O Q1u a bond H a bond NH S NH Q3b OH
    879 N O Q1u a bond H a bond NH S NH Q3c OH
    880 N O Q1u a bond H a bond NH S a bond Q3a OH
    881 N O Q1u a bond H a bond NH S a bond Q3b OH
    882 N O Q1u a bond H a bond NH S a bond Q3c OH
    883 N O Q1u a bond H a bond NH O NH Q3a OH
    884 N O Q1u a bond H a bond NH O NH Q3b OH
    885 N O Q1u a bond H a bond NH O NH Q3c OH
    886 N O Q1u a bond H a bond NH O a bond Q3a OH
    887 N O Q1u a bond H a bond NH O a bond Q3b OH
    888 N O Q1u a bond H a bond NH O a bond Q3c OH
    889 N O Q1v a bond Me a bond NH S NH Q3a OH
    890 N O Q1v a bond Me a bond NH S NH Q3b OH
    891 N O Q1v a bond Me a bond NH S NH Q3c OH
    892 N O Q1v a bond Me a bond NH S a bond Q3a OH
    893 N O Q1v a bond Me a bond NH S a bond Q3b OH
    894 N O Q1v a bond Me a bond NH S a bond Q3c OH
    895 N O Q1v a bond Me a bond NH O NH Q3a OH
    896 N O Q1v a bond Me a bond NH O NH Q3b OH
    897 N O Q1v a bond Me a bond NH O NH Q3c OH
    898 N O Q1v a bond Me a bond NH O a bond Q3a OH
    899 N O Q1v a bond Me a bond NH O a bond Q3b OH
    900 N O Q1v a bond Me a bond NH O a bond Q3c OH
    901 N O Q1v a bond H a bond NH S NH Q3a OH
    902 N O Q1v a bond H a bond NH S NH Q3b OH
    903 N O Q1v a bond H a bond NH S NH Q3c OH
    904 N O Q1v a bond H a bond NH S a bond Q3a OH
    905 N O Q1v a bond H a bond NH S a bond Q3b OH
    906 N O Q1v a bond H a bond NH S a bond Q3c OH
    907 N O Q1v a bond H a bond NH O NH Q3a OH
    908 N O Q1v a bond H a bond NH O NH Q3b OH
    909 N O Q1v a bond H a bond NH O NH Q3c OH
    910 N O Q1v a bond H a bond NH O a bond Q3a OH
    911 N O Q1v a bond H a bond NH O a bond Q3b OH
    912 N O Q1v a bond H a bond NH O a bond Q3c OH
    913 N O Q1w a bond Me a bond NH S NH Q3a OH
    914 N O Q1w a bond Me a bond NH S NH Q3b OH
    915 N O Q1w a bond Me a bond NH S NH Q3c OH
    916 N O Q1w a bond Me a bond NH S a bond Q3a OH
    917 N O Q1w a bond Me a bond NH S a bond Q3b OH
    918 N O Q1w a bond Me a bond NH S a bond Q3c OH
    919 N O Q1w a bond Me a bond NH O NH Q3a OH
    920 N O Q1w a bond Me a bond NH O NH Q3b OH
    921 N O Q1w a bond Me a bond NH O NH Q3c OH
    922 N O Q1w a bond Me a bond NH O a bond Q3a OH
    923 N O Q1w a bond Me a bond NH O a bond Q3b OH
    924 N O Q1w a bond Me a bond NH O a bond Q3c OH
    925 N O Q1w a bond H a bond NH S NH Q3a OH
    926 N O Q1w a bond H a bond NH S NH Q3b OH
    927 N O Q1w a bond H a bond NH S NH Q3c OH
    928 N O Q1w a bond H a bond NH S a bond Q3a OH
    929 N O Q1w a bond H a bond NH S a bond Q3b OH
    930 N O Q1w a bond H a bond NH S a bond Q3c OH
    931 N O Q1w a bond H a bond NH O NH Q3a OH
    932 N O Q1w a bond H a bond NH O NH Q3b OH
    933 N O Q1w a bond H a bond NH O NH Q3c OH
    934 N O Q1w a bond H a bond NH O a bond Q3a OH
    935 N O Q1w a bond H a bond NH O a bond Q3b OH
    936 N O Q1w a bond H a bond NH O a bond Q3c OH
    937 N O Q1x a bond Me a bond NH S NH Q3a OH
    938 N O Q1x a bond Me a bond NH S NH Q3b OH
    939 N O Q1x a bond Me a bond NH S NH Q3c OH
    940 N O Q1x a bond Me a bond NH S a bond Q3a OH
    941 N O Q1x a bond Me a bond NH S a bond Q3b OH
    942 N O Q1x a bond Me a bond NH S a bond Q3c OH
    943 N O Q1x a bond Me a bond NH O NH Q3a OH
    944 N O Q1x a bond Me a bond NH O NH Q3b OH
    945 N O Q1x a bond Me a bond NH O NH Q3c OH
    946 N O Q1x a bond Me a bond NH O a bond Q3a OH
    947 N O Q1x a bond Me a bond NH O a bond Q3b OH
    948 N O Q1x a bond Me a bond NH O a bond Q3c OH
    949 N O Q1x a bond H a bond NH S NH Q3a OH
    950 N O Q1x a bond H a bond NH S NH Q3b OH
    951 N O Q1x a bond H a bond NH S NH Q3c OH
    952 N O Q1x a bond H a bond NH S a bond Q3a OH
    953 N O Q1x a bond H a bond NH S a bond Q3b OH
    954 N O Q1x a bond H a bond NH S a bond Q3c OH
    955 N O Q1x a bond H a bond NH O NH Q3a OH
    956 N O Q1x a bond H a bond NH O NH Q3b OH
    957 N O Q1x a bond H a bond NH O NH Q3c OH
    958 N O Q1x a bond H a bond NH O a bond Q3a OH
    959 N O Q1x a bond H a bond NH O a bond Q3b OH
    960 N O Q1x a bond H a bond NH O a bond Q3c OH
    961 CH NMe Q1o a bond Me a bond NH S NH Q3a OH
    962 CH NMe Q1o a bond Me a bond NH S NH Q3b OH
    963 CH NMe Q1o a bond Me a bond NH S NH Q3c OH
    964 CH NMe Q1o a bond Me a bond NH S a bond Q3a OH
    965 CH NMe Q1o a bond Me a bond NH S a bond Q3b OH
    966 CH NMe Q1o a bond Me a bond NH S a bond Q3c OH
    967 CH NMe Q1o a bond Me a bond NH O NH Q3a OH
    968 CH NMe Q1o a bond Me a bond NH O NH Q3b OH
    969 CH NMe Q1o a bond Me a bond NH O NH Q3c OH
    970 CH NMe Q1o a bond Me a bond NH O a bond Q3a OH
    971 CH NMe Q1o a bond Me a bond NH O a bond Q3b OH
    972 CH NMe Q1o a bond Me a bond NH O a bond Q3c OH
    973 CH NMe Q1o a bond H a bond NH S NH Q3a OH
    974 CH NMe Q1o a bond H a bond NH S NH Q3b OH
    975 CH NMe Q1o a bond H a bond NH S NH Q3c OH
    976 CH NMe Q1o a bond H a bond NH S a bond Q3a OH
    977 CH NMe Q1o a bond H a bond NH S a bond Q3b OH
    978 CH NMe Q1o a bond H a bond NH S a bond Q3c OH
    979 CH NMe Q1o a bond H a bond NH O NH Q3a OH
    980 CH NMe Q1o a bond H a bond NH O NH Q3b OH
    981 CH NMe Q1o a bond H a bond NH O NH Q3c OH
    982 CH NMe Q1o a bond H a bond NH O a bond Q3a OH
    983 CH NMe Q1o a bond H a bond NH O a bond Q3b OH
    984 CH NMe Q1o a bond H a bond NH O a bond Q3c OH
    985 CH NMe Q1p a bond Me a bond NH S NH Q3a OH
    986 CH NMe Q1p a bond Me a bond NH S NH Q3b OH
    987 CH NMe Q1p a bond Me a bond NH S NH Q3c OH
    988 CH NMe Q1p a bond Me a bond NH S a bond Q3a OH
    989 CH NMe Q1p a bond Me a bond NH S a bond Q3b OH
    990 CH NMe Q1p a bond Me a bond NH S a bond Q3c OH
    991 CH NMe Q1p a bond Me a bond NH O NH Q3a OH
    992 CH NMe Q1p a bond Me a bond NH O NH Q3b OH
    993 CH NMe Q1p a bond Me a bond NH O NH Q3c OH
    994 CH NMe Q1p a bond Me a bond NH O a bond Q3a OH
    995 CH NMe Q1p a bond Me a bond NH O a bond Q3b OH
    996 CH NMe Q1p a bond Me a bond NH O a bond Q3c OH
    997 CH NMe Q1p a bond H a bond NH S NH Q3a OH
    998 CH NMe Q1p a bond H a bond NH S NH Q3b OH
    999 CH NMe Q1p a bond H a bond NH S NH Q3c OH
    1000 CH NMe Q1p a bond H a bond NH S a bond Q3a OH
    1001 CH NMe Q1p a bond H a bond NH S a bond Q3b OH
    1002 CH NMe Q1p a bond H a bond NH S a bond Q3c OH
    1003 CH NMe Q1p a bond H a bond NH O NH Q3a OH
    1004 CH NMe Q1p a bond H a bond NH O NH Q3b OH
    1005 CH NMe Q1p a bond H a bond NH O NH Q3c OH
    1006 CH NMe Q1p a bond H a bond NH O a bond Q3a OH
    1007 CH NMe Q1p a bond H a bond NH O a bond Q3b OH
    1008 CH NMe Q1p a bond H a bond NH O a bond Q3c OH
    1009 CH NMe Q1q a bond Me a bond NH S NH Q3a OH
    1010 CH NMe Q1q a bond Me a bond NH S NH Q3b OH
    1011 CH NMe Q1q a bond Me a bond NH S NH Q3c OH
    1012 CH NMe Q1q a bond Me a bond NH S a bond Q3a OH
    1013 CH NMe Q1q a bond Me a bond NH S a bond Q3b OH
    1014 CH NMe Q1q a bond Me a bond NH S a bond Q3c OH
    1015 CH NMe Q1q a bond Me a bond NH O NH Q3a OH
    1016 CH NMe Q1q a bond Me a bond NH O NH Q3b OH
    1017 CH NMe Q1q a bond Me a bond NH O NH Q3c OH
    1018 CH NMe Q1q a bond Me a bond NH O a bond Q3a OH
    1019 CH NMe Q1q a bond Me a bond NH O a bond Q3b OH
    1020 CH NMe Q1q a bond Me a bond NH O a bond Q3c OH
    1021 CH NMe Q1q a bond H a bond NH S NH Q3a OH
    1022 CH NMe Q1q a bond H a bond NH S NH Q3b OH
    1023 CH NMe Q1q a bond H a bond NH S NH Q3c OH
    1024 CH NMe Q1q a bond H a bond NH S a bond Q3a OH
    1025 CH NMe Q1q a bond H a bond NH S a bond Q3b OH
    1026 CH NMe Q1q a bond H a bond NH S a bond Q3c OH
    1027 CH NMe Q1q a bond H a bond NH O NH Q3a OH
    1028 CH NMe Q1q a bond H a bond NH O NH Q3b OH
    1029 CH NMe Q1q a bond H a bond NH O NH Q3c OH
    1030 CH NMe Q1q a bond H a bond NH O a bond Q3a OH
    1031 CH NMe Q1q a bond H a bond NH O a bond Q3b OH
    1032 CH NMe Q1q a bond H a bond NH O a bond Q3c OH
    1033 CH NMe Q1r a bond Me a bond NH S NH Q3a OH
    1034 CH NMe Q1r a bond Me a bond NH S NH Q3b OH
    1035 CH NMe Q1r a bond Me a bond NH S NH Q3c OH
    1036 CH NMe Q1r a bond Me a bond NH S a bond Q3a OH
    1037 CH NMe Q1r a bond Me a bond NH S a bond Q3b OH
    1038 CH NMe Q1r a bond Me a bond NH S a bond Q3c OH
    1039 CH NMe Q1r a bond Me a bond NH O NH Q3a OH
    1040 CH NMe Q1r a bond Me a bond NH O NH Q3b OH
    1041 CH NMe Q1r a bond Me a bond NH O NH Q3c OH
    1042 CH NMe Q1r a bond Me a bond NH O a bond Q3a OH
    1043 CH NMe Q1r a bond Me a bond NH O a bond Q3b OH
    1044 CH NMe Q1r a bond Me a bond NH O a bond Q3c OH
    1045 CH NMe Q1r a bond H a bond NH S NH Q3a OH
    1046 CH NMe Q1r a bond H a bond NH S NH Q3b OH
    1047 CH NMe Q1r a bond H a bond NH S NH Q3c OH
    1048 CH NMe Q1r a bond H a bond NH S a bond Q3a OH
    1049 CH NMe Q1r a bond H a bond NH S a bond Q3b OH
    1050 CH NMe Q1r a bond H a bond NH S a bond Q3c OH
    1051 CH NMe Q1r a bond H a bond NH O NH Q3a OH
    1052 CH NMe Q1r a bond H a bond NH O NH Q3b OH
    1053 CH NMe Q1r a bond H a bond NH O NH Q3c OH
    1054 CH NMe Q1r a bond H a bond NH O a bond Q3a OH
    1055 CH NMe Q1r a bond H a bond NH O a bond Q3b OH
    1056 CH NMe Q1r a bond H a bond NH O a bond Q3c OH
    1057 CH NMe Q1s a bond Me a bond NH S NH Q3a OH
    1058 CH NMe Q1s a bond Me a bond NH S NH Q3b OH
    1059 CH NMe Q1s a bond Me a bond NH S NH Q3c OH
    1060 CH NMe Q1s a bond Me a bond NH S a bond Q3a OH
    1061 CH NMe Q1s a bond Me a bond NH S a bond Q3b OH
    1062 CH NMe Q1s a bond Me a bond NH S a bond Q3c OH
    1063 CH NMe Q1s a bond Me a bond NH O NH Q3a OH
    1064 CH NMe Q1s a bond Me a bond NH O NH Q3b OH
    1065 CH NMe Q1s a bond Me a bond NH O NH Q3c OH
    1066 CH NMe Q1s a bond Me a bond NH O a bond Q3a OH
    1067 CH NMe Q1s a bond Me a bond NH O a bond Q3b OH
    1068 CH NMe Q1s a bond Me a bond NH O a bond Q3c OH
    1069 CH NMe Q1s a bond H a bond NH S NH Q3a OH
    1070 CH NMe Q1s a bond H a bond NH S NH Q3b OH
    1071 CH NMe Q1s a bond H a bond NH S NH Q3c OH
    1072 CH NMe Q1s a bond H a bond NH S a bond Q3a OH
    1073 CH NMe Q1s a bond H a bond NH S a bond Q3b OH
    1074 CH NMe Q1s a bond H a bond NH S a bond Q3c OH
    1075 CH NMe Q1s a bond H a bond NH O NH Q3a OH
    1076 CH NMe Q1s a bond H a bond NH O NH Q3b OH
    1077 CH NMe Q1s a bond H a bond NH O NH Q3c OH
    1078 CH NMe Q1s a bond H a bond NH O a bond Q3a OH
    1079 CH NMe Q1s a bond H a bond NH O a bond Q3b OH
    1080 CH NMe Q1s a bond H a bond NH O a bond Q3c OH
    1081 CH NMe Q1t a bond Me a bond NH S NH Q3a OH
    1082 CH NMe Q1t a bond Me a bond NH S NH Q3b OH
    1083 CH NMe Q1t a bond Me a bond NH S NH Q3c OH
    1084 CH NMe Q1t a bond Me a bond NH S a bond Q3a OH
    1085 CH NMe Q1t a bond Me a bond NH S a bond Q3b OH
    1086 CH NMe Q1t a bond Me a bond NH S a bond Q3c OH
    1087 CH NMe Q1t a bond Me a bond NH O NH Q3a OH
    1088 CH NMe Q1t a bond Me a bond NH O NH Q3b OH
    1089 CH NMe Q1t a bond Me a bond NH O NH Q3c OH
    1090 CH NMe Q1t a bond Me a bond NH O a bond Q3a OH
    1091 CH NMe Q1t a bond Me a bond NH O a bond Q3b OH
    1092 CH NMe Q1t a bond Me a bond NH O a bond Q3c OH
    1093 CH NMe Q1t a bond H a bond NH S NH Q3a OH
    1094 CH NMe Q1t a bond H a bond NH S NH Q3b OH
    1095 CH NMe Q1t a bond H a bond NH S NH Q3c OH
    1096 CH NMe Q1t a bond H a bond NH S a bond Q3a OH
    1097 CH NMe Q1t a bond H a bond NH S a bond Q3b OH
    1098 CH NMe Q1t a bond H a bond NH S a bond Q3c OH
    1099 CH NMe Q1t a bond H a bond NH O NH Q3a OH
    1100 CH NMe Q1t a bond H a bond NH O NH Q3b OH
    1101 CH NMe Q1t a bond H a bond NH O NH Q3c OH
    1102 CH NMe Q1t a bond H a bond NH O a bond Q3a OH
    1103 CH NMe Q1t a bond H a bond NH O a bond Q3b OH
    1104 CH NMe Q1t a bond H a bond NH O a bond Q3c OH
    1105 CH NMe Q1u a bond Me a bond NH S NH Q3a OH
    1106 CH NMe Q1u a bond Me a bond NH S NH Q3b OH
    1107 CH NMe Q1u a bond Me a bond NH S NH Q3c OH
    1108 CH NMe Q1u a bond Me a bond NH S a bond Q3a OH
    1109 CH NMe Q1u a bond Me a bond NH S a bond Q3b OH
    1110 CH NMe Q1u a bond Me a bond NH S a bond Q3c OH
    1111 CH NMe Q1u a bond Me a bond NH O NH Q3a OH
    1112 CH NMe Q1u a bond Me a bond NH O NH Q3b OH
    1113 CH NMe Q1u a bond Me a bond NH O NH Q3c OH
    1114 CH NMe Q1u a bond Me a bond NH O a bond Q3a OH
    1115 CH NMe Q1u a bond Me a bond NH O a bond Q3b OH
    1116 CH NMe Q1u a bond Me a bond NH O a bond Q3c OH
    1117 CH NMe Q1u a bond H a bond NH S NH Q3a OH
    1118 CH NMe Q1u a bond H a bond NH S NH Q3b OH
    1119 CH NMe Q1u a bond H a bond NH S NH Q3c OH
    1120 CH NMe Q1u a bond H a bond NH S a bond Q3a OH
    1121 CH NMe Q1u a bond H a bond NH S a bond Q3b OH
    1122 CH NMe Q1u a bond H a bond NH S a bond Q3c OH
    1123 CH NMe Q1u a bond H a bond NH O NH Q3a OH
    1124 CH NMe Q1u a bond H a bond NH O NH Q3b OH
    1125 CH NMe Q1u a bond H a bond NH O NH Q3c OH
    1126 CH NMe Q1u a bond H a bond NH O a bond Q3a OH
    1127 CH NMe Q1u a bond H a bond NH O a bond Q3b OH
    1128 CH NMe Q1u a bond H a bond NH O a bond Q3c OH
    1129 CH NMe Q1v a bond Me a bond NH S NH Q3a OH
    1130 CH NMe Q1v a bond Me a bond NH S NH Q3b OH
    1131 CH NMe Q1v a bond Me a bond NH S NH Q3c OH
    1132 CH NMe Q1v a bond Me a bond NH S a bond Q3a OH
    1133 CH NMe Q1v a bond Me a bond NH S a bond Q3b OH
    1134 CH NMe Q1v a bond Me a bond NH S a bond Q3c OH
    1135 CH NMe Q1v a bond Me a bond NH O NH Q3a OH
    1136 CH NMe Q1v a bond Me a bond NH O NH Q3b OH
    1137 CH NMe Q1v a bond Me a bond NH O NH Q3c OH
    1138 CH NMe Q1v a bond Me a bond NH O a bond Q3a OH
    1139 CH NMe Q1v a bond Me a bond NH O a bond Q3b OH
    1140 CH NMe Q1v a bond Me a bond NH O a bond Q3c OH
    1141 CH NMe Q1v a bond H a bond NH S NH Q3a OH
    1142 CH NMe Q1v a bond H a bond NH S NH Q3b OH
    1143 CH NMe Q1v a bond H a bond NH S NH Q3c OH
    1144 CH NMe Q1v a bond H a bond NH S a bond Q3a OH
    1145 CH NMe Q1v a bond H a bond NH S a bond Q3b OH
    1146 CH NMe Q1v a bond H a bond NH S a bond Q3c OH
    1147 CH NMe Q1v a bond H a bond NH O NH Q3a OH
    1148 CH NMe Q1v a bond H a bond NH O NH Q3b OH
    1149 CH NMe Q1v a bond H a bond NH O NH Q3c OH
    1150 CH NMe Q1v a bond H a bond NH O a bond Q3a OH
    1151 CH NMe Q1v a bond H a bond NH O a bond Q3b OH
    1152 CH NMe Q1v a bond H a bond NH O a bond Q3c OH
    1153 CH NMe Q1w a bond Me a bond NH S NH Q3a OH
    1154 CH NMe Q1w a bond Me a bond NH S NH Q3b OH
    1155 CH NMe Q1w a bond Me a bond NH S NH Q3c OH
    1156 CH NMe Q1w a bond Me a bond NH S a bond Q3a OH
    1157 CH NMe Q1w a bond Me a bond NH S a bond Q3b OH
    1158 CH NMe Q1w a bond Me a bond NH S a bond Q3c OH
    1159 CH NMe Q1w a bond Me a bond NH O NH Q3a OH
    1160 CH NMe Q1w a bond Me a bond NH O NH Q3b OH
    1161 CH NMe Q1w a bond Me a bond NH O NH Q3c OH
    1162 CH NMe Q1w a bond Me a bond NH O a bond Q3a OH
    1163 CH NMe Q1w a bond Me a bond NH O a bond Q3b OH
    1164 CH NMe Q1w a bond Me a bond NH O a bond Q3c OH
    1165 CH NMe Q1w a bond H a bond NH S NH Q3a OH
    1166 CH NMe Q1w a bond H a bond NH S NH Q3b OH
    1167 CH NMe Q1w a bond H a bond NH S NH Q3c OH
    1168 CH NMe Q1w a bond H a bond NH S a bond Q3a OH
    1169 CH NMe Q1w a bond H a bond NH S a bond Q3b OH
    1170 CH NMe Q1w a bond H a bond NH S a bond Q3c OH
    1171 CH NMe Q1w a bond H a bond NH O NH Q3a OH
    1172 CH NMe Q1w a bond H a bond NH O NH Q3b OH
    1173 CH NMe Q1w a bond H a bond NH O NH Q3c OH
    1174 CH NMe Q1w a bond H a bond NH O a bond Q3a OH
    1175 CH NMe Q1w a bond H a bond NH O a bond Q3b OH
    1176 CH NMe Q1w a bond H a bond NH O a bond Q3c OH
    1177 CH NMe Q1x a bond Me a bond NH S NH Q3a OH
    1178 CH NMe Q1x a bond Me a bond NH S NH Q3b OH
    1179 CH NMe Q1x a bond Me a bond NH S NH Q3c OH
    1180 CH NMe Q1x a bond Me a bond NH S a bond Q3a OH
    1181 CH NMe Q1x a bond Me a bond NH S a bond Q3b OH
    1182 CH NMe Q1x a bond Me a bond NH S a bond Q3c OH
    1183 CH NMe Q1x a bond Me a bond NH O NH Q3a OH
    1184 CH NMe Q1x a bond Me a bond NH O NH Q3b OH
    1185 CH NMe Q1x a bond Me a bond NH O NH Q3c OH
    1186 CH NMe Q1x a bond Me a bond NH O a bond Q3a OH
    1187 CH NMe Q1x a bond Me a bond NH O a bond Q3b OH
    1188 CH NMe Q1x a bond Me a bond NH O a bond Q3c OH
    1189 CH NMe Q1x a bond H a bond NH S NH Q3a OH
    1190 CH NMe Q1x a bond H a bond NH S NH Q3b OH
    1191 CH NMe Q1x a bond H a bond NH S NH Q3c OH
    1192 CH NMe Q1x a bond H a bond NH S a bond Q3a OH
    1193 CH NMe Q1x a bond H a bond NH S a bond Q3b OH
    1194 CH NMe Q1x a bond H a bond NH S a bond Q3c OH
    1195 CH NMe Q1x a bond H a bond NH O NH Q3a OH
    1196 CH NMe Q1x a bond H a bond NH O NH Q3b OH
    1197 CH NMe Q1x a bond H a bond NH O NH Q3c OH
    1198 CH NMe Q1x a bond H a bond NH O a bond Q3a OH
    1199 CH NMe Q1x a bond H a bond NH O a bond Q3b OH
    1200 CH NMe Q1x a bond H a bond NH O a bond Q3c OH
    1201 CH NEt Q1o a bond Me a bond NH S NH Q3a OH
    1202 CH NEt Q1o a bond Me a bond NH S NH Q3b OH
    1203 CH NEt Q1o a bond Me a bond NH S NH Q3c OH
    1204 CH NEt Q1o a bond Me a bond NH S a bond Q3a OH
    1205 CH NEt Q1o a bond Me a bond NH S a bond Q3b OH
    1206 CH NEt Q1o a bond Me a bond NH S a bond Q3c OH
    1207 CH NEt Q1o a bond Me a bond NH O NH Q3a OH
    1208 CH NEt Q1o a bond Me a bond NH O NH Q3b OH
    1209 CH NEt Q1o a bond Me a bond NH O NH Q3c OH
    1210 CH NEt Q1o a bond Me a bond NH O a bond Q3a OH
    1211 CH NEt Q1o a bond Me a bond NH O a bond Q3b OH
    1212 CH NEt Q1o a bond Me a bond NH O a bond Q3c OH
    1213 CH NEt Q1o a bond H a bond NH S NH Q3a OH
    1214 CH NEt Q1o a bond H a bond NH S NH Q3b OH
    1215 CH NEt Q1o a bond H a bond NH S NH Q3c OH
    1216 CH NEt Q1o a bond H a bond NH S a bond Q3a OH
    1217 CH NEt Q1o a bond H a bond NH S a bond Q3b OH
    1218 CH NEt Q1o a bond H a bond NH S a bond Q3c OH
    1219 CH NEt Q1o a bond H a bond NH O NH Q3a OH
    1220 CH NEt Q1o a bond H a bond NH O NH Q3b OH
    1221 CH NEt Q1o a bond H a bond NH O NH Q3c OH
    1222 CH NEt Q1o a bond H a bond NH O a bond Q3a OH
    1223 CH NEt Q1o a bond H a bond NH O a bond Q3b OH
    1224 CH NEt Q1o a bond H a bond NH O a bond Q3c OH
    1225 CH NEt Q1p a bond Me a bond NH S NH Q3a OH
    1226 CH NEt Q1p a bond Me a bond NH S NH Q3b OH
    1227 CH NEt Q1p a bond Me a bond NH S NH Q3c OH
    1228 CH NEt Q1p a bond Me a bond NH S a bond Q3a OH
    1229 CH NEt Q1p a bond Me a bond NH S a bond Q3b OH
    1230 CH NEt Q1p a bond Me a bond NH S a bond Q3c OH
    1231 CH NEt Q1p a bond Me a bond NH O NH Q3a OH
    1232 CH NEt Q1p a bond Me a bond NH O NH Q3b OH
    1233 CH NEt Q1p a bond Me a bond NH O NH Q3c OH
    1234 CH NEt Q1p a bond Me a bond NH O a bond Q3a OH
    1235 CH NEt Q1p a bond Me a bond NH O a bond Q3b OH
    1236 CH NEt Q1p a bond Me a bond NH O a bond Q3c OH
    1237 CH NEt Q1p a bond H a bond NH S NH Q3a OH
    1238 CH NEt Q1p a bond H a bond NH S NH Q3b OH
    1239 CH NEt Q1p a bond H a bond NH S NH Q3c OH
    1240 CH NEt Q1p a bond H a bond NH S a bond Q3a OH
    1241 CH NEt Q1p a bond H a bond NH S a bond Q3b OH
    1242 CH NEt Q1p a bond H a bond NH S a bond Q3c OH
    1243 CH NEt Q1p a bond H a bond NH O NH Q3a OH
    1244 CH NEt Q1p a bond H a bond NH O NH Q3b OH
    1245 CH NEt Q1p a bond H a bond NH O NH Q3c OH
    1246 CH NEt Q1p a bond H a bond NH O a bond Q3a OH
    1247 CH NEt Q1p a bond H a bond NH O a bond Q3b OH
    1248 CH NEt Q1p a bond H a bond NH O a bond Q3c OH
    1249 CH NEt Q1q a bond Me a bond NH S NH Q3a OH
    1250 CH NEt Q1q a bond Me a bond NH S NH Q3b OH
    1251 CH NEt Q1q a bond Me a bond NH S NH Q3c OH
    1252 CH NEt Q1q a bond Me a bond NH S a bond Q3a OH
    1253 CH NEt Q1q a bond Me a bond NH S a bond Q3b OH
    1254 CH NEt Q1q a bond Me a bond NH S a bond Q3c OH
    1255 CH NEt Q1q a bond Me a bond NH O NH Q3a OH
    1256 CH NEt Q1q a bond Me a bond NH O NH Q3b OH
    1257 CH NEt Q1q a bond Me a bond NH O NH Q3c OH
    1258 CH NEt Q1q a bond Me a bond NH O a bond Q3a OH
    1259 CH NEt Q1q a bond Me a bond NH O a bond Q3b OH
    1260 CH NEt Q1q a bond Me a bond NH O a bond Q3c OH
    1261 CH NEt Q1q a bond H a bond NH S NH Q3a OH
    1262 CH NEt Q1q a bond H a bond NH S NH Q3b OH
    1263 CH NEt Q1q a bond H a bond NH S NH Q3c OH
    1264 CH NEt Q1q a bond H a bond NH S a bond Q3a OH
    1265 CH NEt Q1q a bond H a bond NH S a bond Q3b OH
    1266 CH NEt Q1q a bond H a bond NH S a bond Q3c OH
    1267 CH NEt Q1q a bond H a bond NH O NH Q3a OH
    1268 CH NEt Q1q a bond H a bond NH O NH Q3b OH
    1269 CH NEt Q1q a bond H a bond NH O NH Q3c OH
    1270 CH NEt Q1q a bond H a bond NH O a bond Q3a OH
    1271 CH NEt Q1q a bond H a bond NH O a bond Q3b OH
    1272 CH NEt Q1q a bond H a bond NH O a bond Q3c OH
    1273 CH NEt Q1r a bond Me a bond NH S NH Q3a OH
    1274 CH NEt Q1r a bond Me a bond NH S NH Q3b OH
    1275 CH NEt Q1r a bond Me a bond NH S NH Q3c OH
    1276 CH NEt Q1r a bond Me a bond NH S a bond Q3a OH
    1277 CH NEt Q1r a bond Me a bond NH S a bond Q3b OH
    1278 CH NEt Q1r a bond Me a bond NH S a bond Q3c OH
    1279 CH NEt Q1r a bond Me a bond NH O NH Q3a OH
    1280 CH NEt Q1r a bond Me a bond NH O NH Q3b OH
    1281 CH NEt Q1r a bond Me a bond NH O NH Q3c OH
    1282 CH NEt Q1r a bond Me a bond NH O a bond Q3a OH
    1283 CH NEt Q1r a bond Me a bond NH O a bond Q3b OH
    1284 CH NEt Q1r a bond Me a bond NH O a bond Q3c OH
    1285 CH NEt Q1r a bond H a bond NH S NH Q3a OH
    1286 CH NEt Q1r a bond H a bond NH S NH Q3b OH
    1287 CH NEt Q1r a bond H a bond NH S NH Q3c OH
    1288 CH NEt Q1r a bond H a bond NH S a bond Q3a OH
    1289 CH NEt Q1r a bond H a bond NH S a bond Q3b OH
    1290 CH NEt Q1r a bond H a bond NH S a bond Q3c OH
    1291 CH NEt Q1r a bond H a bond NH O NH Q3a OH
    1292 CH NEt Q1r a bond H a bond NH O NH Q3b OH
    1293 CH NEt Q1r a bond H a bond NH O NH Q3c OH
    1294 CH NEt Q1r a bond H a bond NH O a bond Q3a OH
    1295 CH NEt Q1r a bond H a bond NH O a bond Q3b OH
    1296 CH NEt Q1r a bond H a bond NH O a bond Q3c OH
    1297 CH NEt Q1s a bond Me a bond NH S NH Q3a OH
    1298 CH NEt Q1s a bond Me a bond NH S NH Q3b OH
    1299 CH NEt Q1s a bond Me a bond NH S NH Q3c OH
    1300 CH NEt Q1s a bond Me a bond NH S a bond Q3a OH
    1301 CH NEt Q1s a bond Me a bond NH S a bond Q3b OH
    1302 CH NEt Q1s a bond Me a bond NH S a bond Q3c OH
    1303 CH NEt Q1s a bond Me a bond NH O NH Q3a OH
    1304 CH NEt Q1s a bond Me a bond NH O NH Q3b OH
    1305 CH NEt Q1s a bond Me a bond NH O NH Q3c OH
    1306 CH NEt Q1s a bond Me a bond NH O a bond Q3a OH
    1307 CH NEt Q1s a bond Me a bond NH O a bond Q3b OH
    1308 CH NEt Q1s a bond Me a bond NH O a bond Q3c OH
    1309 CH NEt Q1s a bond H a bond NH S NH Q3a OH
    1310 CH NEt Q1s a bond H a bond NH S NH Q3b OH
    1311 CH NEt Q1s a bond H a bond NH S NH Q3c OH
    1312 CH NEt Q1s a bond H a bond NH S a bond Q3a OH
    1313 CH NEt Q1s a bond H a bond NH S a bond Q3b OH
    1314 CH NEt Q1s a bond H a bond NH S a bond Q3c OH
    1315 CH NEt Q1s a bond H a bond NH O NH Q3a OH
    1316 CH NEt Q1s a bond H a bond NH O NH Q3b OH
    1317 CH NEt Q1s a bond H a bond NH O NH Q3c OH
    1318 CH NEt Q1s a bond H a bond NH O a bond Q3a OH
    1319 CH NEt Q1s a bond H a bond NH O a bond Q3b OH
    1320 CH NEt Q1s a bond H a bond NH O a bond Q3c OH
    1321 CH NEt Q1t a bond Me a bond NH S NH Q3a OH
    1322 CH NEt Q1t a bond Me a bond NH S NH Q3b OH
    1323 CH NEt Q1t a bond Me a bond NH S NH Q3c OH
    1324 CH NEt Q1t a bond Me a bond NH S a bond Q3a OH
    1325 CH NEt Q1t a bond Me a bond NH S a bond Q3b OH
    1326 CH NEt Q1t a bond Me a bond NH S a bond Q3c OH
    1327 CH NEt Q1t a bond Me a bond NH O NH Q3a OH
    1328 CH NEt Q1t a bond Me a bond NH O NH Q3b OH
    1329 CH NEt Q1t a bond Me a bond NH O NH Q3c OH
    1330 CH NEt Q1t a bond Me a bond NH O a bond Q3a OH
    1331 CH NEt Q1t a bond Me a bond NH O a bond Q3b OH
    1332 CH NEt Q1t a bond Me a bond NH O a bond Q3c OH
    1333 CH NEt Q1t a bond H a bond NH S NH Q3a OH
    1334 CH NEt Q1t a bond H a bond NH S NH Q3b OH
    1335 CH NEt Q1t a bond H a bond NH S NH Q3c OH
    1336 CH NEt Q1t a bond H a bond NH S a bond Q3a OH
    1337 CH NEt Q1t a bond H a bond NH S a bond Q3b OH
    1338 CH NEt Q1t a bond H a bond NH S a bond Q3c OH
    1339 CH NEt Q1t a bond H a bond NH O NH Q3a OH
    1340 CH NEt Q1t a bond H a bond NH O NH Q3b OH
    1341 CH NEt Q1t a bond H a bond NH O NH Q3c OH
    1342 CH NEt Q1t a bond H a bond NH O a bond Q3a OH
    1343 CH NEt Q1t a bond H a bond NH O a bond Q3b OH
    1344 CH NEt Q1t a bond H a bond NH O a bond Q3c OH
    1345 CH NEt Q1u a bond Me a bond NH S NH Q3a OH
    1346 CH NEt Q1u a bond Me a bond NH S NH Q3b OH
    1347 CH NEt Q1u a bond Me a bond NH S NH Q3c OH
    1348 CH NEt Q1u a bond Me a bond NH S a bond Q3a OH
    1349 CH NEt Q1u a bond Me a bond NH S a bond Q3b OH
    1350 CH NEt Q1u a bond Me a bond NH S a bond Q3c OH
    1351 CH NEt Q1u a bond Me a bond NH O NH Q3a OH
    1352 CH NEt Q1u a bond Me a bond NH O NH Q3b OH
    1353 CH NEt Q1u a bond Me a bond NH O NH Q3c OH
    1354 CH NEt Q1u a bond Me a bond NH O a bond Q3a OH
    1355 CH NEt Q1u a bond Me a bond NH O a bond Q3b OH
    1356 CH NEt Q1u a bond Me a bond NH O a bond Q3c OH
    1357 CH NEt Q1u a bond H a bond NH S NH Q3a OH
    1358 CH NEt Q1u a bond H a bond NH S NH Q3b OH
    1359 CH NEt Q1u a bond H a bond NH S NH Q3c OH
    1360 CH NEt Q1u a bond H a bond NH S a bond Q3a OH
    1361 CH NEt Q1u a bond H a bond NH S a bond Q3b OH
    1362 CH NEt Q1u a bond H a bond NH S a bond Q3c OH
    1363 CH NEt Q1u a bond H a bond NH O NH Q3a OH
    1364 CH NEt Q1u a bond H a bond NH O NH Q3b OH
    1365 CH NEt Q1u a bond H a bond NH O NH Q3c OH
    1366 CH NEt Q1u a bond H a bond NH O a bond Q3a OH
    1367 CH NEt Q1u a bond H a bond NH O a bond Q3b OH
    1368 CH NEt Q1u a bond H a bond NH O a bond Q3c OH
    1369 CH NEt Q1v a bond Me a bond NH S NH Q3a OH
    1370 CH NEt Q1v a bond Me a bond NH S NH Q3b OH
    1371 CH NEt Q1v a bond Me a bond NH S NH Q3c OH
    1372 CH NEt Q1v a bond Me a bond NH S a bond Q3a OH
    1373 CH NEt Q1v a bond Me a bond NH S a bond Q3b OH
    1374 CH NEt Q1v a bond Me a bond NH S a bond Q3c OH
    1375 CH NEt Q1v a bond Me a bond NH O NH Q3a OH
    1376 CH NEt Q1v a bond Me a bond NH O NH Q3b OH
    1377 CH NEt Q1v a bond Me a bond NH O NH Q3c OH
    1378 CH NEt Q1v a bond Me a bond NH O a bond Q3a OH
    1379 CH NEt Q1v a bond Me a bond NH O a bond Q3b OH
    1380 CH NEt Q1v a bond Me a bond NH O a bond Q3c OH
    1381 CH NEt Q1v a bond H a bond NH S NH Q3a OH
    1382 CH NEt Q1v a bond H a bond NH S NH Q3b OH
    1383 CH NEt Q1v a bond H a bond NH S NH Q3c OH
    1384 CH NEt Q1v a bond H a bond NH S a bond Q3a OH
    1385 CH NEt Q1v a bond H a bond NH S a bond Q3b OH
    1386 CH NEt Q1v a bond H a bond NH S a bond Q3c OH
    1387 CH NEt Q1v a bond H a bond NH O NH Q3a OH
    1388 CH NEt Q1v a bond H a bond NH O NH Q3b OH
    1389 CH NEt Q1v a bond H a bond NH O NH Q3c OH
    1390 CH NEt Q1v a bond H a bond NH O a bond Q3a OH
    1391 CH NEt Q1v a bond H a bond NH O a bond Q3b OH
    1392 CH NEt Q1v a bond H a bond NH O a bond Q3c OH
    1393 CH NEt Q1w a bond Me a bond NH S NH Q3a OH
    1394 CH NEt Q1w a bond Me a bond NH S NH Q3b OH
    1395 CH NEt Q1w a bond Me a bond NH S NH Q3c OH
    1396 CH NEt Q1w a bond Me a bond NH S a bond Q3a OH
    1397 CH NEt Q1w a bond Me a bond NH S a bond Q3b OH
    1398 CH NEt Q1w a bond Me a bond NH S a bond Q3c OH
    1399 CH NEt Q1w a bond Me a bond NH O NH Q3a OH
    1400 CH NEt Q1w a bond Me a bond NH O NH Q3b OH
    1401 CH NEt Q1w a bond Me a bond NH O NH Q3c OH
    1402 CH NEt Q1w a bond Me a bond NH O a bond Q3a OH
    1403 CH NEt Q1w a bond Me a bond NH O a bond Q3b OH
    1404 CH NEt Q1w a bond Me a bond NH O a bond Q3c OH
    1405 CH NEt Q1w a bond H a bond NH S NH Q3a OH
    1406 CH NEt Q1w a bond H a bond NH S NH Q3b OH
    1407 CH NEt Q1w a bond H a bond NH S NH Q3c OH
    1408 CH NEt Q1w a bond H a bond NH S a bond Q3a OH
    1409 CH NEt Q1w a bond H a bond NH S a bond Q3b OH
    1410 CH NEt Q1w a bond H a bond NH S a bond Q3c OH
    1411 CH NEt Q1w a bond H a bond NH O NH Q3a OH
    1412 CH NEt Q1w a bond H a bond NH O NH Q3b OH
    1413 CH NEt Q1w a bond H a bond NH O NH Q3c OH
    1414 CH NEt Q1w a bond H a bond NH O a bond Q3a OH
    1415 CH NEt Q1w a bond H a bond NH O a bond Q3b OH
    1416 CH NEt Q1w a bond H a bond NH O a bond Q3c OH
    1417 CH NEt Q1x a bond Me a bond NH S NH Q3a OH
    1418 CH NEt Q1x a bond Me a bond NH S NH Q3b OH
    1419 CH NEt Q1x a bond Me a bond NH S NH Q3c OH
    1420 CH NEt Q1x a bond Me a bond NH S a bond Q3a OH
    1421 CH NEt Q1x a bond Me a bond NH S a bond Q3b OH
    1422 CH NEt Q1x a bond Me a bond NH S a bond Q3c OH
    1423 CH NEt Q1x a bond Me a bond NH O NH Q3a OH
    1424 CH NEt Q1x a bond Me a bond NH O NH Q3b OH
    1425 CH NEt Q1x a bond Me a bond NH O NH Q3c OH
    1426 CH NEt Q1x a bond Me a bond NH O a bond Q3a OH
    1427 CH NEt Q1x a bond Me a bond NH O a bond Q3b OH
    1428 CH NEt Q1x a bond Me a bond NH O a bond Q3c OH
    1429 CH NEt Q1x a bond H a bond NH S NH Q3a OH
    1430 CH NEt Q1x a bond H a bond NH S NH Q3b OH
    1431 CH NEt Q1x a bond H a bond NH S NH Q3c OH
    1432 CH NEt Q1x a bond H a bond NH S a bond Q3a OH
    1433 CH NEt Q1x a bond H a bond NH S a bond Q3b OH
    1434 CH NEt Q1x a bond H a bond NH S a bond Q3c OH
    1435 CH NEt Q1x a bond H a bond NH O NH Q3a OH
    1436 CH NEt Q1x a bond H a bond NH O NH Q3b OH
    1437 CH NEt Q1x a bond H a bond NH O NH Q3c OH
    1438 CH NEt Q1x a bond H a bond NH O a bond Q3a OH
    1439 CH NEt Q1x a bond H a bond NH O a bond Q3b OH
    1440 CH NEt Q1x a bond H a bond NH O a bond Q3c OH
    1441 CH S Q1o a bond Me a bond NH S NH Q3a OH
    1442 CH S Q1o a bond Me a bond NH S NH Q3b OH
    1443 CH S Q1o a bond Me a bond NH S NH Q3c OH
    1444 CH S Q1o a bond Me a bond NH S a bond Q3a OH
    1445 CH S Q1o a bond Me a bond NH S a bond Q3b OH
    1446 CH S Q1o a bond Me a bond NH S a bond Q3c OH
    1447 CH S Q1o a bond Me a bond NH O NH Q3a OH
    1448 CH S Q1o a bond Me a bond NH O NH Q3b OH
    1449 CH S Q1o a bond Me a bond NH O NH Q3c OH
    1450 CH S Q1o a bond Me a bond NH O a bond Q3a OH
    1451 CH S Q1o a bond Me a bond NH O a bond Q3b OH
    1452 CH S Q1o a bond Me a bond NH O a bond Q3c OH
    1453 CH S Q1o a bond H a bond NH S NH Q3a OH
    1454 CH S Q1o a bond H a bond NH S NH Q3b OH
    1455 CH S Q1o a bond H a bond NH S NH Q3c OH
    1456 CH S Q1o a bond H a bond NH S a bond Q3a OH
    1457 CH S Q1o a bond H a bond NH S a bond Q3b OH
    1458 CH S Q1o a bond H a bond NH S a bond Q3c OH
    1459 CH S Q1o a bond H a bond NH O NH Q3a OH
    1460 CH S Q1o a bond H a bond NH O NH Q3b OH
    1461 CH S Q1o a bond H a bond NH O NH Q3c OH
    1462 CH S Q1o a bond H a bond NH O a bond Q3a OH
    1463 CH S Q1o a bond H a bond NH O a bond Q3b OH
    1464 CH S Q1o a bond H a bond NH O a bond Q3c OH
    1465 CH S Q1p a bond Me a bond NH S NH Q3a OH
    1466 CH S Q1p a bond Me a bond NH S NH Q3b OH
    1467 CH S Q1p a bond Me a bond NH S NH Q3c OH
    1468 CH S Q1p a bond Me a bond NH S a bond Q3a OH
    1469 CH S Q1p a bond Me a bond NH S a bond Q3b OH
    1470 CH S Q1p a bond Me a bond NH S a bond Q3c OH
    1471 CH S Q1p a bond Me a bond NH O NH Q3a OH
    1472 CH S Q1p a bond Me a bond NH O NH Q3b OH
    1473 CH S Q1p a bond Me a bond NH O NH Q3c OH
    1474 CH S Q1p a bond Me a bond NH O a bond Q3a OH
    1475 CH S Q1p a bond Me a bond NH O a bond Q3b OH
    1476 CH S Q1p a bond Me a bond NH O a bond Q3c OH
    1477 CH S Q1p a bond H a bond NH S NH Q3a OH
    1478 CH S Q1p a bond H a bond NH S NH Q3b OH
    1479 CH S Q1p a bond H a bond NH S NH Q3c OH
    1480 CH S Q1p a bond H a bond NH S a bond Q3a OH
    1481 CH S Q1p a bond H a bond NH S a bond Q3b OH
    1482 CH S Q1p a bond H a bond NH S a bond Q3c OH
    1483 CH S Q1p a bond H a bond NH O NH Q3a OH
    1484 CH S Q1p a bond H a bond NH O NH Q3b OH
    1485 CH S Q1p a bond H a bond NH O NH Q3c OH
    1486 CH S Q1p a bond H a bond NH O a bond Q3a OH
    1487 CH S Q1p a bond H a bond NH O a bond Q3b OH
    1488 CH S Q1p a bond H a bond NH O a bond Q3c OH
    1489 CH S Q1q a bond Me a bond NH S NH Q3a OH
    1490 CH S Q1q a bond Me a bond NH S NH Q3b OH
    1491 CH S Q1q a bond Me a bond NH S NH Q3c OH
    1492 CH S Q1q a bond Me a bond NH S a bond Q3a OH
    1493 CH S Q1q a bond Me a bond NH S a bond Q3b OH
    1494 CH S Q1q a bond Me a bond NH S a bond Q3c OH
    1495 CH S Q1q a bond Me a bond NH O NH Q3a OH
    1496 CH S Q1q a bond Me a bond NH O NH Q3b OH
    1497 CH S Q1q a bond Me a bond NH O NH Q3c OH
    1498 CH S Q1q a bond Me a bond NH O a bond Q3a OH
    1499 CH S Q1q a bond Me a bond NH O a bond Q3b OH
    1500 CH S Q1q a bond Me a bond NH O a bond Q3c OH
    1501 CH S Q1q a bond H a bond NH S NH Q3a OH
    1502 CH S Q1q a bond H a bond NH S NH Q3b OH
    1503 CH S Q1q a bond H a bond NH S NH Q3c OH
    1504 CH S Q1q a bond H a bond NH S a bond Q3a OH
    1505 CH S Q1q a bond H a bond NH S a bond Q3b OH
    1506 CH S Q1q a bond H a bond NH S a bond Q3c OH
    1507 CH S Q1q a bond H a bond NH O NH Q3a OH
    1508 CH S Q1q a bond H a bond NH O NH Q3b OH
    1509 CH S Q1q a bond H a bond NH O NH Q3c OH
    1510 CH S Q1q a bond H a bond NH O a bond Q3a OH
    1511 CH S Q1q a bond H a bond NH O a bond Q3b OH
    1512 CH S Q1q a bond H a bond NH O a bond Q3c OH
    1513 CH S Q1r a bond Me a bond NH S NH Q3a OH
    1514 CH S Q1r a bond Me a bond NH S NH Q3b OH
    1515 CH S Q1r a bond Me a bond NH S NH Q3c OH
    1516 CH S Q1r a bond Me a bond NH S a bond Q3a OH
    1517 CH S Q1r a bond Me a bond NH S a bond Q3b OH
    1518 CH S Q1r a bond Me a bond NH S a bond Q3c OH
    1519 CH S Q1r a bond Me a bond NH O NH Q3a OH
    1520 CH S Q1r a bond Me a bond NH O NH Q3b OH
    1521 CH S Q1r a bond Me a bond NH O NH Q3c OH
    1522 CH S Q1r a bond Me a bond NH O a bond Q3a OH
    1523 CH S Q1r a bond Me a bond NH O a bond Q3b OH
    1524 CH S Q1r a bond Me a bond NH O a bond Q3c OH
    1525 CH S Q1r a bond H a bond NH S NH Q3a OH
    1526 CH S Q1r a bond H a bond NH S NH Q3b OH
    1527 CH S Q1r a bond H a bond NH S NH Q3c OH
    1528 CH S Q1r a bond H a bond NH S a bond Q3a OH
    1529 CH S Q1r a bond H a bond NH S a bond Q3b OH
    1530 CH S Q1r a bond H a bond NH S a bond Q3c OH
    1531 CH S Q1r a bond H a bond NH O NH Q3a OH
    1532 CH S Q1r a bond H a bond NH O NH Q3b OH
    1533 CH S Q1r a bond H a bond NH O NH Q3c OH
    1534 CH S Q1r a bond H a bond NH O a bond Q3a OH
    1535 CH S Q1r a bond H a bond NH O a bond Q3b OH
    1536 CH S Q1r a bond H a bond NH O a bond Q3c OH
    1537 CH S Q1s a bond Me a bond NH S NH Q3a OH
    1538 CH S Q1s a bond Me a bond NH S NH Q3b OH
    1539 CH S Q1s a bond Me a bond NH S NH Q3c OH
    1540 CH S Q1s a bond Me a bond NH S a bond Q3a OH
    1541 CH S Q1s a bond Me a bond NH S a bond Q3b OH
    1542 CH S Q1s a bond Me a bond NH S a bond Q3c OH
    1543 CH S Q1s a bond Me a bond NH O NH Q3a OH
    1544 CH S Q1s a bond Me a bond NH O NH Q3b OH
    1545 CH S Q1s a bond Me a bond NH O NH Q3c OH
    1546 CH S Q1s a bond Me a bond NH O a bond Q3a OH
    1547 CH S Q1s a bond Me a bond NH O a bond Q3b OH
    1548 CH S Q1s a bond Me a bond NH O a bond Q3c OH
    1549 CH S Q1s a bond H a bond NH S NH Q3a OH
    1550 CH S Q1s a bond H a bond NH S NH Q3b OH
    1551 CH S Q1s a bond H a bond NH S NH Q3c OH
    1552 CH S Q1s a bond H a bond NH S a bond Q3a OH
    1553 CH S Q1s a bond H a bond NH S a bond Q3b OH
    1554 CH S Q1s a bond H a bond NH S a bond Q3c OH
    1555 CH S Q1s a bond H a bond NH O NH Q3a OH
    1556 CH S Q1s a bond H a bond NH O NH Q3b OH
    1557 CH S Q1s a bond H a bond NH O NH Q3c OH
    1558 CH S Q1s a bond H a bond NH O a bond Q3a OH
    1559 CH S Q1s a bond H a bond NH O a bond Q3b OH
    1560 CH S Q1s a bond H a bond NH O a bond Q3c OH
    1561 CH S Q1t a bond Me a bond NH S NH Q3a OH
    1562 CH S Q1t a bond Me a bond NH S NH Q3b OH
    1563 CH S Q1t a bond Me a bond NH S NH Q3c OH
    1564 CH S Q1t a bond Me a bond NH S a bond Q3a OH
    1565 CH S Q1t a bond Me a bond NH S a bond Q3b OH
    1566 CH S Q1t a bond Me a bond NH S a bond Q3c OH
    1567 CH S Q1t a bond Me a bond NH O NH Q3a OH
    1568 CH S Q1t a bond Me a bond NH O NH Q3b OH
    1569 CH S Q1t a bond Me a bond NH O NH Q3c OH
    1570 CH S Q1t a bond Me a bond NH O a bond Q3a OH
    1571 CH S Q1t a bond Me a bond NH O a bond Q3b OH
    1572 CH S Q1t a bond Me a bond NH O a bond Q3c OH
    1573 CH S Q1t a bond H a bond NH S NH Q3a OH
    1574 CH S Q1t a bond H a bond NH S NH Q3b OH
    1575 CH S Q1t a bond H a bond NH S NH Q3c OH
    1576 CH S Q1t a bond H a bond NH S a bond Q3a OH
    1577 CH S Q1t a bond H a bond NH S a bond Q3b OH
    1578 CH S Q1t a bond H a bond NH S a bond Q3c OH
    1579 CH S Q1t a bond H a bond NH O NH Q3a OH
    1580 CH S Q1t a bond H a bond NH O NH Q3b OH
    1581 CH S Q1t a bond H a bond NH O NH Q3c OH
    1582 CH S Q1t a bond H a bond NH O a bond Q3a OH
    1583 CH S Q1t a bond H a bond NH O a bond Q3b OH
    1584 CH S Q1t a bond H a bond NH O a bond Q3c OH
    1585 CH S Q1u a bond Me a bond NH S NH Q3a OH
    1586 CH S Q1u a bond Me a bond NH S NH Q3b OH
    1587 CH S Q1u a bond Me a bond NH S NH Q3c OH
    1588 CH S Q1u a bond Me a bond NH S a bond Q3a OH
    1589 CH S Q1u a bond Me a bond NH S a bond Q3b OH
    1590 CH S Q1u a bond Me a bond NH S a bond Q3c OH
    1591 CH S Q1u a bond Me a bond NH O NH Q3a OH
    1592 CH S Q1u a bond Me a bond NH O NH Q3b OH
    1593 CH S Q1u a bond Me a bond NH O NH Q3c OH
    1594 CH S Q1u a bond Me a bond NH O a bond Q3a OH
    1595 CH S Q1u a bond Me a bond NH O a bond Q3b OH
    1596 CH S Q1u a bond Me a bond NH O a bond Q3c OH
    1597 CH S Q1u a bond H a bond NH S NH Q3a OH
    1598 CH S Q1u a bond H a bond NH S NH Q3b OH
    1599 CH S Q1u a bond H a bond NH S NH Q3c OH
    1600 CH S Q1u a bond H a bond NH S a bond Q3a OH
    1601 CH S Q1u a bond H a bond NH S a bond Q3b OH
    1602 CH S Q1u a bond H a bond NH S a bond Q3c OH
    1603 CH S Q1u a bond H a bond NH O NH Q3a OH
    1604 CH S Q1u a bond H a bond NH O NH Q3b OH
    1605 CH S Q1u a bond H a bond NH O NH Q3c OH
    1606 CH S Q1u a bond H a bond NH O a bond Q3a OH
    1607 CH S Q1u a bond H a bond NH O a bond Q3b OH
    1608 CH S Q1u a bond H a bond NH O a bond Q3c OH
    1609 CH S Q1v a bond Me a bond NH S NH Q3a OH
    1610 CH S Q1v a bond Me a bond NH S NH Q3b OH
    1611 CH S Q1v a bond Me a bond NH S NH Q3c OH
    1612 CH S Q1v a bond Me a bond NH S a bond Q3a OH
    1613 CH S Q1v a bond Me a bond NH S a bond Q3b OH
    1614 CH S Q1v a bond Me a bond NH S a bond Q3c OH
    1615 CH S Q1v a bond Me a bond NH O NH Q3a OH
    1616 CH S Q1v a bond Me a bond NH O NH Q3b OH
    1617 CH S Q1v a bond Me a bond NH O NH Q3c OH
    1618 CH S Q1v a bond Me a bond NH O a bond Q3a OH
    1619 CH S Q1v a bond Me a bond NH O a bond Q3b OH
    1620 CH S Q1v a bond Me a bond NH O a bond Q3c OH
    1621 CH S Q1v a bond H a bond NH S NH Q3a OH
    1622 CH S Q1v a bond H a bond NH S NH Q3b OH
    1623 CH S Q1v a bond H a bond NH S NH Q3c OH
    1624 CH S Q1v a bond H a bond NH S a bond Q3a OH
    1625 CH S Q1v a bond H a bond NH S a bond Q3b OH
    1626 CH S Q1v a bond H a bond NH S a bond Q3c OH
    1627 CH S Q1v a bond H a bond NH O NH Q3a OH
    1628 CH S Q1v a bond H a bond NH O NH Q3b OH
    1629 CH S Q1v a bond H a bond NH O NH Q3c OH
    1630 CH S Q1v a bond H a bond NH O a bond Q3a OH
    1631 CH S Q1v a bond H a bond NH O a bond Q3b OH
    1632 CH S Q1v a bond H a bond NH O a bond Q3c OH
    1633 CH S Q1w a bond Me a bond NH S NH Q3a OH
    1634 CH S Q1w a bond Me a bond NH S NH Q3b OH
    1635 CH S Q1w a bond Me a bond NH S NH Q3c OH
    1636 CH S Q1w a bond Me a bond NH S a bond Q3a OH
    1637 CH S Q1w a bond Me a bond NH S a bond Q3b OH
    1638 CH S Q1w a bond Me a bond NH S a bond Q3c OH
    1639 CH S Q1w a bond Me a bond NH O NH Q3a OH
    1640 CH S Q1w a bond Me a bond NH O NH Q3b OH
    1641 CH S Q1w a bond Me a bond NH O NH Q3c OH
    1642 CH S Q1w a bond Me a bond NH O a bond Q3a OH
    1643 CH S Q1w a bond Me a bond NH O a bond Q3b OH
    1644 CH S Q1w a bond Me a bond NH O a bond Q3c OH
    1645 CH S Q1w a bond H a bond NH S NH Q3a OH
    1646 CH S Q1w a bond H a bond NH S NH Q3b OH
    1647 CH S Q1w a bond H a bond NH S NH Q3c OH
    1648 CH S Q1w a bond H a bond NH S a bond Q3a OH
    1649 CH S Q1w a bond H a bond NH S a bond Q3b OH
    1650 CH S Q1w a bond H a bond NH S a bond Q3c OH
    1651 CH S Q1w a bond H a bond NH O NH Q3a OH
    1652 CH S Q1w a bond H a bond NH O NH Q3b OH
    1653 CH S Q1w a bond H a bond NH O NH Q3c OH
    1654 CH S Q1w a bond H a bond NH O a bond Q3a OH
    1655 CH S Q1w a bond H a bond NH O a bond Q3b OH
    1656 CH S Q1w a bond H a bond NH O a bond Q3c OH
    1657 CH S Q1x a bond Me a bond NH S NH Q3a OH
    1658 CH S Q1x a bond Me a bond NH S NH Q3b OH
    1659 CH S Q1x a bond Me a bond NH S NH Q3c OH
    1660 CH S Q1x a bond Me a bond NH S a bond Q3a OH
    1661 CH S Q1x a bond Me a bond NH S a bond Q3b OH
    1662 CH S Q1x a bond Me a bond NH S a bond Q3c OH
    1663 CH S Q1x a bond Me a bond NH O NH Q3a OH
    1664 CH S Q1x a bond Me a bond NH O NH Q3b OH
    1665 CH S Q1x a bond Me a bond NH O NH Q3c OH
    1666 CH S Q1x a bond Me a bond NH O a bond Q3a OH
    1667 CH S Q1x a bond Me a bond NH O a bond Q3b OH
    1668 CH S Q1x a bond Me a bond NH O a bond Q3c OH
    1669 CH S Q1x a bond H a bond NH S NH Q3a OH
    1670 CH S Q1x a bond H a bond NH S NH Q3b OH
    1671 CH S Q1x a bond H a bond NH S NH Q3c OH
    1672 CH S Q1x a bond H a bond NH S a bond Q3a OH
    1673 CH S Q1x a bond H a bond NH S a bond Q3b OH
    1674 CH S Q1x a bond H a bond NH S a bond Q3c OH
    1675 CH S Q1x a bond H a bond NH O NH Q3a OH
    1676 CH S Q1x a bond H a bond NH O NH Q3b OH
    1677 CH S Q1x a bond H a bond NH O NH Q3c OH
    1678 CH S Q1x a bond H a bond NH O a bond Q3a OH
    1679 CH S Q1x a bond H a bond NH O a bond Q3b OH
    1680 CH S Q1x a bond H a bond NH O a bond Q3c OH
    1681 CH O Q1o a bond Me a bond NH S NH Q3a OH
    1682 CH O Q1o a bond Me a bond NH S NH Q3b OH
    1683 CH O Q1o a bond Me a bond NH S NH Q3c OH
    1684 CH O Q1o a bond Me a bond NH S a bond Q3a OH
    1685 CH O Q1o a bond Me a bond NH S a bond Q3b OH
    1686 CH O Q1o a bond Me a bond NH S a bond Q3c OH
    1687 CH O Q1o a bond Me a bond NH O NH Q3a OH
    1688 CH O Q1o a bond Me a bond NH O NH Q3b OH
    1689 CH O Q1o a bond Me a bond NH O NH Q3c OH
    1690 CH O Q1o a bond Me a bond NH O a bond Q3a OH
    1691 CH O Q1o a bond Me a bond NH O a bond Q3b OH
    1692 CH O Q1o a bond Me a bond NH O a bond Q3c OH
    1693 CH O Q1o a bond H a bond NH S NH Q3a OH
    1694 CH O Q1o a bond H a bond NH S NH Q3b OH
    1695 CH O Q1o a bond H a bond NH S NH Q3c OH
    1696 CH O Q1o a bond H a bond NH S a bond Q3a OH
    1697 CH O Q1o a bond H a bond NH S a bond Q3b OH
    1698 CH O Q1o a bond H a bond NH S a bond Q3c OH
    1699 CH O Q1o a bond H a bond NH O NH Q3a OH
    1700 CH O Q1o a bond H a bond NH O NH Q3b OH
    1701 CH O Q1o a bond H a bond NH O NH Q3c OH
    1702 CH O Q1o a bond H a bond NH O a bond Q3a OH
    1703 CH O Q1o a bond H a bond NH O a bond Q3b OH
    1704 CH O Q1o a bond H a bond NH O a bond Q3c OH
    1705 CH O Q1p a bond Me a bond NH S NH Q3a OH
    1706 CH O Q1p a bond Me a bond NH S NH Q3b OH
    1707 CH O Q1p a bond Me a bond NH S NH Q3c OH
    1708 CH O Q1p a bond Me a bond NH S a bond Q3a OH
    1709 CH O Q1p a bond Me a bond NH S a bond Q3b OH
    1710 CH O Q1p a bond Me a bond NH S a bond Q3c OH
    1711 CH O Q1p a bond Me a bond NH O NH Q3a OH
    1712 CH O Q1p a bond Me a bond NH O NH Q3b OH
    1713 CH O Q1p a bond Me a bond NH O NH Q3c OH
    1714 CH O Q1p a bond Me a bond NH O a bond Q3a OH
    1715 CH O Q1p a bond Me a bond NH O a bond Q3b OH
    1716 CH O Q1p a bond Me a bond NH O a bond Q3c OH
    1717 CH O Q1p a bond H a bond NH S NH Q3a OH
    1718 CH O Q1p a bond H a bond NH S NH Q3b OH
    1719 CH O Q1p a bond H a bond NH S NH Q3c OH
    1720 CH O Q1p a bond H a bond NH S a bond Q3a OH
    1721 CH O Q1p a bond H a bond NH S a bond Q3b OH
    1722 CH O Q1p a bond H a bond NH S a bond Q3c OH
    1723 CH O Q1p a bond H a bond NH O NH Q3a OH
    1724 CH O Q1p a bond H a bond NH O NH Q3b OH
    1725 CH O Q1p a bond H a bond NH O NH Q3c OH
    1726 CH O Q1p a bond H a bond NH O a bond Q3a OH
    1727 CH O Q1p a bond H a bond NH O a bond Q3b OH
    1728 CH O Q1p a bond H a bond NH O a bond Q3c OH
    1729 CH O Q1q a bond Me a bond NH S NH Q3a OH
    1730 CH O Q1q a bond Me a bond NH S NH Q3b OH
    1731 CH O Q1q a bond Me a bond NH S NH Q3c OH
    1732 CH O Q1q a bond Me a bond NH S a bond Q3a OH
    1733 CH O Q1q a bond Me a bond NH S a bond Q3b OH
    1734 CH O Q1q a bond Me a bond NH S a bond Q3c OH
    1735 CH O Q1q a bond Me a bond NH O NH Q3a OH
    1736 CH O Q1q a bond Me a bond NH O NH Q3b OH
    1737 CH O Q1q a bond Me a bond NH O NH Q3c OH
    1738 CH O Q1q a bond Me a bond NH O a bond Q3a OH
    1739 CH O Q1q a bond Me a bond NH O a bond Q3b OH
    1740 CH O Q1q a bond Me a bond NH O a bond Q3c OH
    1741 CH O Q1q a bond H a bond NH S NH Q3a OH
    1742 CH O Q1q a bond H a bond NH S NH Q3b OH
    1743 CH O Q1q a bond H a bond NH S NH Q3c OH
    1744 CH O Q1q a bond H a bond NH S a bond Q3a OH
    1745 CH O Q1q a bond H a bond NH S a bond Q3b OH
    1746 CH O Q1q a bond H a bond NH S a bond Q3c OH
    1747 CH O Q1q a bond H a bond NH O NH Q3a OH
    1748 CH O Q1q a bond H a bond NH O NH Q3b OH
    1749 CH O Q1q a bond H a bond NH O NH Q3c OH
    1750 CH O Q1q a bond H a bond NH O a bond Q3a OH
    1751 CH O Q1q a bond H a bond NH O a bond Q3b OH
    1752 CH O Q1q a bond H a bond NH O a bond Q3c OH
    1753 CH O Q1r a bond Me a bond NH S NH Q3a OH
    1754 CH O Q1r a bond Me a bond NH S NH Q3b OH
    1755 CH O Q1r a bond Me a bond NH S NH Q3c OH
    1756 CH O Q1r a bond Me a bond NH S a bond Q3a OH
    1757 CH O Q1r a bond Me a bond NH S a bond Q3b OH
    1758 CH O Q1r a bond Me a bond NH S a bond Q3c OH
    1759 CH O Q1r a bond Me a bond NH O NH Q3a OH
    1760 CH O Q1r a bond Me a bond NH O NH Q3b OH
    1761 CH O Q1r a bond Me a bond NH O NH Q3c OH
    1762 CH O Q1r a bond Me a bond NH O a bond Q3a OH
    1763 CH O Q1r a bond Me a bond NH O a bond Q3b OH
    1764 CH O Q1r a bond Me a bond NH O a bond Q3c OH
    1765 CH O Q1r a bond H a bond NH S NH Q3a OH
    1766 CH O Q1r a bond H a bond NH S NH Q3b OH
    1767 CH O Q1r a bond H a bond NH S NH Q3c OH
    1768 CH O Q1r a bond H a bond NH S a bond Q3a OH
    1769 CH O Q1r a bond H a bond NH S a bond Q3b OH
    1770 CH O Q1r a bond H a bond NH S a bond Q3c OH
    1771 CH O Q1r a bond H a bond NH O NH Q3a OH
    1772 CH O Q1r a bond H a bond NH O NH Q3b OH
    1773 CH O Q1r a bond H a bond NH O NH Q3c OH
    1774 CH O Q1r a bond H a bond NH O a bond Q3a OH
    1775 CH O Q1r a bond H a bond NH O a bond Q3b OH
    1776 CH O Q1r a bond H a bond NH O a bond Q3c OH
    1777 CH O Q1s a bond Me a bond NH S NH Q3a OH
    1778 CH O Q1s a bond Me a bond NH S NH Q3b OH
    1779 CH O Q1s a bond Me a bond NH S NH Q3c OH
    1780 CH O Q1s a bond Me a bond NH S a bond Q3a OH
    1781 CH O Q1s a bond Me a bond NH S a bond Q3b OH
    1782 CH O Q1s a bond Me a bond NH S a bond Q3c OH
    1783 CH O Q1s a bond Me a bond NH O NH Q3a OH
    1784 CH O Q1s a bond Me a bond NH O NH Q3b OH
    1785 CH O Q1s a bond Me a bond NH O NH Q3c OH
    1786 CH O Q1s a bond Me a bond NH O a bond Q3a OH
    1787 CH O Q1s a bond Me a bond NH O a bond Q3b OH
    1788 CH O Q1s a bond Me a bond NH O a bond Q3c OH
    1789 CH O Q1s a bond H a bond NH S NH Q3a OH
    1790 CH O Q1s a bond H a bond NH S NH Q3b OH
    1791 CH O Q1s a bond H a bond NH S NH Q3c OH
    1792 CH O Q1s a bond H a bond NH S a bond Q3a OH
    1793 CH O Q1s a bond H a bond NH S a bond Q3b OH
    1794 CH O Q1s a bond H a bond NH S a bond Q3c OH
    1795 CH O Q1s a bond H a bond NH O NH Q3a OH
    1796 CH O Q1s a bond H a bond NH O NH Q3b OH
    1797 CH O Q1s a bond H a bond NH O NH Q3c OH
    1798 CH O Q1s a bond H a bond NH O a bond Q3a OH
    1799 CH O Q1s a bond H a bond NH O a bond Q3b OH
    1800 CH O Q1s a bond H a bond NH O a bond Q3c OH
    1801 CH O Q1t a bond Me a bond NH S NH Q3a OH
    1802 CH O Q1t a bond Me a bond NH S NH Q3b OH
    1803 CH O Q1t a bond Me a bond NH S NH Q3c OH
    1804 CH O Q1t a bond Me a bond NH S a bond Q3a OH
    1805 CH O Q1t a bond Me a bond NH S a bond Q3b OH
    1806 CH O Q1t a bond Me a bond NH S a bond Q3c OH
    1807 CH O Q1t a bond Me a bond NH O NH Q3a OH
    1808 CH O Q1t a bond Me a bond NH O NH Q3b OH
    1809 CH O Q1t a bond Me a bond NH O NH Q3c OH
    1810 CH O Q1t a bond Me a bond NH O a bond Q3a OH
    1811 CH O Q1t a bond Me a bond NH O a bond Q3b OH
    1812 CH O Q1t a bond Me a bond NH O a bond Q3c OH
    1813 CH O Q1t a bond H a bond NH S NH Q3a OH
    1814 CH O Q1t a bond H a bond NH S NH Q3b OH
    1815 CH O Q1t a bond H a bond NH S NH Q3c OH
    1816 CH O Q1t a bond H a bond NH S a bond Q3a OH
    1817 CH O Q1t a bond H a bond NH S a bond Q3b OH
    1818 CH O Q1t a bond H a bond NH S a bond Q3c OH
    1819 CH O Q1t a bond H a bond NH O NH Q3a OH
    1820 CH O Q1t a bond H a bond NH O NH Q3b OH
    1821 CH O Q1t a bond H a bond NH O NH Q3c OH
    1822 CH O Q1t a bond H a bond NH O a bond Q3a OH
    1823 CH O Q1t a bond H a bond NH O a bond Q3b OH
    1824 CH O Q1t a bond H a bond NH O a bond Q3c OH
    1825 CH O Q1u a bond Me a bond NH S NH Q3a OH
    1826 CH O Q1u a bond Me a bond NH S NH Q3b OH
    1827 CH O Q1u a bond Me a bond NH S NH Q3c OH
    1828 CH O Q1u a bond Me a bond NH S a bond Q3a OH
    1829 CH O Q1u a bond Me a bond NH S a bond Q3b OH
    1830 CH O Q1u a bond Me a bond NH S a bond Q3c OH
    1831 CH O Q1u a bond Me a bond NH O NH Q3a OH
    1832 CH O Q1u a bond Me a bond NH O NH Q3b OH
    1833 CH O Q1u a bond Me a bond NH O NH Q3c OH
    1834 CH O Q1u a bond Me a bond NH O a bond Q3a OH
    1835 CH O Q1u a bond Me a bond NH O a bond Q3b OH
    1836 CH O Q1u a bond Me a bond NH O a bond Q3c OH
    1837 CH O Q1u a bond H a bond NH S NH Q3a OH
    1838 CH O Q1u a bond H a bond NH S NH Q3b OH
    1839 CH O Q1u a bond H a bond NH S NH Q3c OH
    1840 CH O Q1u a bond H a bond NH S a bond Q3a OH
    1841 CH O Q1u a bond H a bond NH S a bond Q3b OH
    1842 CH O Q1u a bond H a bond NH S a bond Q3c OH
    1843 CH O Q1u a bond H a bond NH O NH Q3a OH
    1844 CH O Q1u a bond H a bond NH O NH Q3b OH
    1845 CH O Q1u a bond H a bond NH O NH Q3c OH
    1846 CH O Q1u a bond H a bond NH O a bond Q3a OH
    1847 CH O Q1u a bond H a bond NH O a bond Q3b OH
    1848 CH O Q1u a bond H a bond NH O a bond Q3c OH
    1849 CH O Q1v a bond Me a bond NH S NH Q3a OH
    1850 CH O Q1v a bond Me a bond NH S NH Q3b OH
    1851 CH O Q1v a bond Me a bond NH S NH Q3c OH
    1852 CH O Q1v a bond Me a bond NH S a bond Q3a OH
    1853 CH O Q1v a bond Me a bond NH S a bond Q3b OH
    1854 CH O Q1v a bond Me a bond NH S a bond Q3c OH
    1855 CH O Q1v a bond Me a bond NH O NH Q3a OH
    1856 CH O Q1v a bond Me a bond NH O NH Q3b OH
    1857 CH O Q1v a bond Me a bond NH O NH Q3c OH
    1858 CH O Q1v a bond Me a bond NH O a bond Q3a OH
    1859 CH O Q1v a bond Me a bond NH O a bond Q3b OH
    1860 CH O Q1v a bond Me a bond NH O a bond Q3c OH
    1861 CH O Q1v a bond H a bond NH S NH Q3a OH
    1862 CH O Q1v a bond H a bond NH S NH Q3b OH
    1863 CH O Q1v a bond H a bond NH S NH Q3c OH
    1864 CH O Q1v a bond H a bond NH S a bond Q3a OH
    1865 CH O Q1v a bond H a bond NH S a bond Q3b OH
    1866 CH O Q1v a bond H a bond NH S a bond Q3c OH
    1867 CH O Q1v a bond H a bond NH O NH Q3a OH
    1868 CH O Q1v a bond H a bond NH O NH Q3b OH
    1869 CH O Q1v a bond H a bond NH O NH Q3c OH
    1870 CH O Q1v a bond H a bond NH O a bond Q3a OH
    1871 CH O Q1v a bond H a bond NH O a bond Q3b OH
    1872 CH O Q1v a bond H a bond NH O a bond Q3c OH
    1873 CH O Q1w a bond Me a bond NH S NH Q3a OH
    1874 CH O Q1w a bond Me a bond NH S NH Q3b OH
    1875 CH O Q1w a bond Me a bond NH S NH Q3c OH
    1876 CH O Q1w a bond Me a bond NH S a bond Q3a OH
    1877 CH O Q1w a bond Me a bond NH S a bond Q3b OH
    1878 CH O Q1w a bond Me a bond NH S a bond Q3c OH
    1879 CH O Q1w a bond Me a bond NH O NH Q3a OH
    1880 CH O Q1w a bond Me a bond NH O NH Q3b OH
    1881 CH O Q1w a bond Me a bond NH O NH Q3c OH
    1882 CH O Q1w a bond Me a bond NH O a bond Q3a OH
    1883 CH O Q1w a bond Me a bond NH O a bond Q3b OH
    1884 CH O Q1w a bond Me a bond NH O a bond Q3c OH
    1885 CH O Q1w a bond H a bond NH S NH Q3a OH
    1886 CH O Q1w a bond H a bond NH S NH Q3b OH
    1887 CH O Q1w a bond H a bond NH S NH Q3c OH
    1888 CH O Q1w a bond H a bond NH S a bond Q3a OH
    1889 CH O Q1w a bond H a bond NH S a bond Q3b OH
    1890 CH O Q1w a bond H a bond NH S a bond Q3c OH
    1891 CH O Q1w a bond H a bond NH O NH Q3a OH
    1892 CH O Q1w a bond H a bond NH O NH Q3b OH
    1893 CH O Q1w a bond H a bond NH O NH Q3c OH
    1894 CH O Q1w a bond H a bond NH O a bond Q3a OH
    1895 CH O Q1w a bond H a bond NH O a bond Q3b OH
    1896 CH O Q1w a bond H a bond NH O a bond Q3c OH
    1897 CH O Q1x a bond Me a bond NH S NH Q3a OH
    1898 CH O Q1x a bond Me a bond NH S NH Q3b OH
    1899 CH O Q1x a bond Me a bond NH S NH Q3c OH
    1900 CH O Q1x a bond Me a bond NH S a bond Q3a OH
    1901 CH O Q1x a bond Me a bond NH S a bond Q3b OH
    1902 CH O Q1x a bond Me a bond NH S a bond Q3c OH
    1903 CH O Q1x a bond Me a bond NH O NH Q3a OH
    1904 CH O Q1x a bond Me a bond NH O NH Q3b OH
    1905 CH O Q1x a bond Me a bond NH O NH Q3c OH
    1906 CH O Q1x a bond Me a bond NH O a bond Q3a OH
    1907 CH O Q1x a bond Me a bond NH O a bond Q3b OH
    1908 CH O Q1x a bond Me a bond NH O a bond Q3c OH
    1909 CH O Q1x a bond H a bond NH S NH Q3a OH
    1910 CH O Q1x a bond H a bond NH S NH Q3b OH
    1911 CH O Q1x a bond H a bond NH S NH Q3c OH
    1912 CH O Q1x a bond H a bond NH S a bond Q3a OH
    1913 CH O Q1x a bond H a bond NH S a bond Q3b OH
    1914 CH O Q1x a bond H a bond NH S a bond Q3c OH
    1915 CH O Q1x a bond H a bond NH O NH Q3a OH
    1916 CH O Q1x a bond H a bond NH O NH Q3b OH
    1917 CH O Q1x a bond H a bond NH O NH Q3c OH
    1918 CH O Q1x a bond H a bond NH O a bond Q3a OH
    1919 CH O Q1x a bond H a bond NH O a bond Q3b OH
    1920 CH O Q1x a bond H a bond NH O a bond Q3c OH
    1921 CMe NMe Q1o a bond Me a bond NH S NH Q3a OH
    1922 CMe NMe Q1o a bond Me a bond NH S NH Q3b OH
    1923 CMe NMe Q1o a bond Me a bond NH S NH Q3c OH
    1924 CMe NMe Q1o a bond Me a bond NH S a bond Q3a OH
    1925 CMe NMe Q1o a bond Me a bond NH S a bond Q3b OH
    1926 CMe NMe Q1o a bond Me a bond NH S a bond Q3c OH
    1927 CMe NMe Q1o a bond Me a bond NH O NH Q3a OH
    1928 CMe NMe Q1o a bond Me a bond NH O NH Q3b OH
    1929 CMe NMe Q1o a bond Me a bond NH O NH Q3c OH
    1930 CMe NMe Q1o a bond Me a bond NH O a bond Q3a OH
    1931 CMe NMe Q1o a bond Me a bond NH O a bond Q3b OH
    1932 CMe NMe Q1o a bond Me a bond NH O a bond Q3c OH
    1933 CMe NMe Q1o a bond H a bond NH S NH Q3a OH
    1934 CMe NMe Q1o a bond H a bond NH S NH Q3b OH
    1935 CMe NMe Q1o a bond H a bond NH S NH Q3c OH
    1936 CMe NMe Q1o a bond H a bond NH S a bond Q3a OH
    1937 CMe NMe Q1o a bond H a bond NH S a bond Q3b OH
    1938 CMe NMe Q1o a bond H a bond NH S a bond Q3c OH
    1939 CMe NMe Q1o a bond H a bond NH O NH Q3a OH
    1940 CMe NMe Q1o a bond H a bond NH O NH Q3b OH
    1941 CMe NMe Q1o a bond H a bond NH O NH Q3c OH
    1942 CMe NMe Q1o a bond H a bond NH O a bond Q3a OH
    1943 CMe NMe Q1o a bond H a bond NH O a bond Q3b OH
    1944 CMe NMe Q1o a bond H a bond NH O a bond Q3c OH
    1945 CMe NMe Q1p a bond Me a bond NH S NH Q3a OH
    1946 CMe NMe Q1p a bond Me a bond NH S NH Q3b OH
    1947 CMe NMe Q1p a bond Me a bond NH S NH Q3c OH
    1948 CMe NMe Q1p a bond Me a bond NH S a bond Q3a OH
    1949 CMe NMe Q1p a bond Me a bond NH S a bond Q3b OH
    1950 CMe NMe Q1p a bond Me a bond NH S a bond Q3c OH
    1951 CMe NMe Q1p a bond Me a bond NH O NH Q3a OH
    1952 CMe NMe Q1p a bond Me a bond NH O NH Q3b OH
    1953 CMe NMe Q1p a bond Me a bond NH O NH Q3c OH
    1954 CMe NMe Q1p a bond Me a bond NH O a bond Q3a OH
    1955 CMe NMe Q1p a bond Me a bond NH O a bond Q3b OH
    1956 CMe NMe Q1p a bond Me a bond NH O a bond Q3c OH
    1957 CMe NMe Q1p a bond H a bond NH S NH Q3a OH
    1958 CMe NMe Q1p a bond H a bond NH S NH Q3b OH
    1959 CMe NMe Q1p a bond H a bond NH S NH Q3c OH
    1960 CMe NMe Q1p a bond H a bond NH S a bond Q3a OH
    1961 CMe NMe Q1p a bond H a bond NH S a bond Q3b OH
    1962 CMe NMe Q1p a bond H a bond NH S a bond Q3c OH
    1963 CMe NMe Q1p a bond H a bond NH O NH Q3a OH
    1964 CMe NMe Q1p a bond H a bond NH O NH Q3b OH
    1965 CMe NMe Q1p a bond H a bond NH O NH Q3c OH
    1966 CMe NMe Q1p a bond H a bond NH O a bond Q3a OH
    1967 CMe NMe Q1p a bond H a bond NH O a bond Q3b OH
    1968 CMe NMe Q1p a bond H a bond NH O a bond Q3c OH
    1969 CMe NMe Q1q a bond Me a bond NH S NH Q3a OH
    1970 CMe NMe Q1q a bond Me a bond NH S NH Q3b OH
    1971 CMe NMe Q1q a bond Me a bond NH S NH Q3c OH
    1972 CMe NMe Q1q a bond Me a bond NH S a bond Q3a OH
    1973 CMe NMe Q1q a bond Me a bond NH S a bond Q3b OH
    1974 CMe NMe Q1q a bond Me a bond NH S a bond Q3c OH
    1975 CMe NMe Q1q a bond Me a bond NH O NH Q3a OH
    1976 CMe NMe Q1q a bond Me a bond NH O NH Q3b OH
    1977 CMe NMe Q1q a bond Me a bond NH O NH Q3c OH
    1978 CMe NMe Q1q a bond Me a bond NH O a bond Q3a OH
    1979 CMe NMe Q1q a bond Me a bond NH O a bond Q3b OH
    1980 CMe NMe Q1q a bond Me a bond NH O a bond Q3c OH
    1981 CMe NMe Q1q a bond H a bond NH S NH Q3a OH
    1982 CMe NMe Q1q a bond H a bond NH S NH Q3b OH
    1983 CMe NMe Q1q a bond H a bond NH S NH Q3c OH
    1984 CMe NMe Q1q a bond H a bond NH S a bond Q3a OH
    1985 CMe NMe Q1q a bond H a bond NH S a bond Q3b OH
    1986 CMe NMe Q1q a bond H a bond NH S a bond Q3c OH
    1987 CMe NMe Q1q a bond H a bond NH O NH Q3a OH
    1988 CMe NMe Q1q a bond H a bond NH O NH Q3b OH
    1989 CMe NMe Q1q a bond H a bond NH O NH Q3c OH
    1990 CMe NMe Q1q a bond H a bond NH O a bond Q3a OH
    1991 CMe NMe Q1q a bond H a bond NH O a bond Q3b OH
    1992 CMe NMe Q1q a bond H a bond NH O a bond Q3c OH
    1993 CMe NMe Q1r a bond Me a bond NH S NH Q3a OH
    1994 CMe NMe Q1r a bond Me a bond NH S NH Q3b OH
    1995 CMe NMe Q1r a bond Me a bond NH S NH Q3c OH
    1996 CMe NMe Q1r a bond Me a bond NH S a bond Q3a OH
    1997 CMe NMe Q1r a bond Me a bond NH S a bond Q3b OH
    1998 CMe NMe Q1r a bond Me a bond NH S a bond Q3c OH
    1999 CMe NMe Q1r a bond Me a bond NH O NH Q3a OH
    2000 CMe NMe Q1r a bond Me a bond NH O NH Q3b OH
    2001 CMe NMe Q1r a bond Me a bond NH O NH Q3c OH
    2002 CMe NMe Q1r a bond Me a bond NH O a bond Q3a OH
    2003 CMe NMe Q1r a bond Me a bond NH O a bond Q3b OH
    2004 CMe NMe Q1r a bond Me a bond NH O a bond Q3c OH
    2005 CMe NMe Q1r a bond H a bond NH S NH Q3a OH
    2006 CMe NMe Q1r a bond H a bond NH S NH Q3b OH
    2007 CMe NMe Q1r a bond H a bond NH S NH Q3c OH
    2008 CMe NMe Q1r a bond H a bond NH S a bond Q3a OH
    2009 CMe NMe Q1r a bond H a bond NH S a bond Q3b OH
    2010 CMe NMe Q1r a bond H a bond NH S a bond Q3c OH
    2011 CMe NMe Q1r a bond H a bond NH O NH Q3a OH
    2012 CMe NMe Q1r a bond H a bond NH O NH Q3b OH
    2013 CMe NMe Q1r a bond H a bond NH O NH Q3c OH
    2014 CMe NMe Q1r a bond H a bond NH O a bond Q3a OH
    2015 CMe NMe Q1r a bond H a bond NH O a bond Q3b OH
    2016 CMe NMe Q1r a bond H a bond NH O a bond Q3c OH
    2017 CMe NMe Q1s a bond Me a bond NH S NH Q3a OH
    2018 CMe NMe Q1s a bond Me a bond NH S NH Q3b OH
    2019 CMe NMe Q1s a bond Me a bond NH S NH Q3c OH
    2020 CMe NMe Q1s a bond Me a bond NH S a bond Q3a OH
    2021 CMe NMe Q1s a bond Me a bond NH S a bond Q3b OH
    2022 CMe NMe Q1s a bond Me a bond NH S a bond Q3c OH
    2023 CMe NMe Q1s a bond Me a bond NH O NH Q3a OH
    2024 CMe NMe Q1s a bond Me a bond NH O NH Q3b OH
    2025 CMe NMe Q1s a bond Me a bond NH O NH Q3c OH
    2026 CMe NMe Q1s a bond Me a bond NH O a bond Q3a OH
    2027 CMe NMe Q1s a bond Me a bond NH O a bond Q3b OH
    2028 CMe NMe Q1s a bond Me a bond NH O a bond Q3c OH
    2029 CMe NMe Q1s a bond H a bond NH S NH Q3a OH
    2030 CMe NMe Q1s a bond H a bond NH S NH Q3b OH
    2031 CMe NMe Q1s a bond H a bond NH S NH Q3c OH
    2032 CMe NMe Q1s a bond H a bond NH S a bond Q3a OH
    2033 CMe NMe Q1s a bond H a bond NH S a bond Q3b OH
    2034 CMe NMe Q1s a bond H a bond NH S a bond Q3c OH
    2035 CMe NMe Q1s a bond H a bond NH O NH Q3a OH
    2036 CMe NMe Q1s a bond H a bond NH O NH Q3b OH
    2037 CMe NMe Q1s a bond H a bond NH O NH Q3c OH
    2038 CMe NMe Q1s a bond H a bond NH O a bond Q3a OH
    2039 CMe NMe Q1s a bond H a bond NH O a bond Q3b OH
    2040 CMe NMe Q1s a bond H a bond NH O a bond Q3c OH
    2041 CMe NMe Q1t a bond Me a bond NH S NH Q3a OH
    2042 CMe NMe Q1t a bond Me a bond NH S NH Q3b OH
    2043 CMe NMe Q1t a bond Me a bond NH S NH Q3c OH
    2044 CMe NMe Q1t a bond Me a bond NH S a bond Q3a OH
    2045 CMe NMe Q1t a bond Me a bond NH S a bond Q3b OH
    2046 CMe NMe Q1t a bond Me a bond NH S a bond Q3c OH
    2047 CMe NMe Q1t a bond Me a bond NH O NH Q3a OH
    2048 CMe NMe Q1t a bond Me a bond NH O NH Q3b OH
    2049 CMe NMe Q1t a bond Me a bond NH O NH Q3c OH
    2050 CMe NMe Q1t a bond Me a bond NH O a bond Q3a OH
    2051 CMe NMe Q1t a bond Me a bond NH O a bond Q3b OH
    2052 CMe NMe Q1t a bond Me a bond NH O a bond Q3c OH
    2053 CMe NMe Q1t a bond H a bond NH S NH Q3a OH
    2054 CMe NMe Q1t a bond H a bond NH S NH Q3b OH
    2055 CMe NMe Q1t a bond H a bond NH S NH Q3c OH
    2056 CMe NMe Q1t a bond H a bond NH S a bond Q3a OH
    2057 CMe NMe Q1t a bond H a bond NH S a bond Q3b OH
    2058 CMe NMe Q1t a bond H a bond NH S a bond Q3c OH
    2059 CMe NMe Q1t a bond H a bond NH O NH Q3a OH
    2060 CMe NMe Q1t a bond H a bond NH O NH Q3b OH
    2061 CMe NMe Q1t a bond H a bond NH O NH Q3c OH
    2062 CMe NMe Q1t a bond H a bond NH O a bond Q3a OH
    2063 CMe NMe Q1t a bond H a bond NH O a bond Q3b OH
    2064 CMe NMe Q1t a bond H a bond NH O a bond Q3c OH
    2065 CMe NMe Q1u a bond Me a bond NH S NH Q3a OH
    2066 CMe NMe Q1u a bond Me a bond NH S NH Q3b OH
    2067 CMe NMe Q1u a bond Me a bond NH S NH Q3c OH
    2068 CMe NMe Q1u a bond Me a bond NH S a bond Q3a OH
    2069 CMe NMe Q1u a bond Me a bond NH S a bond Q3b OH
    2070 CMe NMe Q1u a bond Me a bond NH S a bond Q3c OH
    2071 CMe NMe Q1u a bond Me a bond NH O NH Q3a OH
    2072 CMe NMe Q1u a bond Me a bond NH O NH Q3b OH
    2073 CMe NMe Q1u a bond Me a bond NH O NH Q3c OH
    2074 CMe NMe Q1u a bond Me a bond NH O a bond Q3a OH
    2075 CMe NMe Q1u a bond Me a bond NH O a bond Q3b OH
    2076 CMe NMe Q1u a bond Me a bond NH O a bond Q3c OH
    2077 CMe NMe Q1u a bond H a bond NH S NH Q3a OH
    2078 CMe NMe Q1u a bond H a bond NH S NH Q3b OH
    2079 CMe NMe Q1u a bond H a bond NH S NH Q3c OH
    2080 CMe NMe Q1u a bond H a bond NH S a bond Q3a OH
    2081 CMe NMe Q1u a bond H a bond NH S a bond Q3b OH
    2082 CMe NMe Q1u a bond H a bond NH S a bond Q3c OH
    2083 CMe NMe Q1u a bond H a bond NH O NH Q3a OH
    2084 CMe NMe Q1u a bond H a bond NH O NH Q3b OH
    2085 CMe NMe Q1u a bond H a bond NH O NH Q3c OH
    2086 CMe NMe Q1u a bond H a bond NH O a bond Q3a OH
    2087 CMe NMe Q1u a bond H a bond NH O a bond Q3b OH
    2088 CMe NMe Q1u a bond H a bond NH O a bond Q3c OH
    2089 CMe NMe Q1v a bond Me a bond NH S NH Q3a OH
    2090 CMe NMe Q1v a bond Me a bond NH S NH Q3b OH
    2091 CMe NMe Q1v a bond Me a bond NH S NH Q3c OH
    2092 CMe NMe Q1v a bond Me a bond NH S a bond Q3a OH
    2093 CMe NMe Q1v a bond Me a bond NH S a bond Q3b OH
    2094 CMe NMe Q1v a bond Me a bond NH S a bond Q3c OH
    2095 CMe NMe Q1v a bond Me a bond NH O NH Q3a OH
    2096 CMe NMe Q1v a bond Me a bond NH O NH Q3b OH
    2097 CMe NMe Q1v a bond Me a bond NH O NH Q3c OH
    2098 CMe NMe Q1v a bond Me a bond NH O a bond Q3a OH
    2099 CMe NMe Q1v a bond Me a bond NH O a bond Q3b OH
    2100 CMe NMe Q1v a bond Me a bond NH O a bond Q3c OH
    2101 CMe NMe Q1v a bond H a bond NH S NH Q3a OH
    2102 CMe NMe Q1v a bond H a bond NH S NH Q3b OH
    2103 CMe NMe Q1v a bond H a bond NH S NH Q3c OH
    2104 CMe NMe Q1v a bond H a bond NH S a bond Q3a OH
    2105 CMe NMe Q1v a bond H a bond NH S a bond Q3b OH
    2106 CMe NMe Q1v a bond H a bond NH S a bond Q3c OH
    2107 CMe NMe Q1v a bond H a bond NH O NH Q3a OH
    2108 CMe NMe Q1v a bond H a bond NH O NH Q3b OH
    2109 CMe NMe Q1v a bond H a bond NH O NH Q3c OH
    2110 CMe NMe Q1v a bond H a bond NH O a bond Q3a OH
    2111 CMe NMe Q1v a bond H a bond NH O a bond Q3b OH
    2112 CMe NMe Q1v a bond H a bond NH O a bond Q3c OH
    2113 CMe NMe Q1w a bond Me a bond NH S NH Q3a OH
    2114 CMe NMe Q1w a bond Me a bond NH S NH Q3b OH
    2115 CMe NMe Q1w a bond Me a bond NH S NH Q3c OH
    2116 CMe NMe Q1w a bond Me a bond NH S a bond Q3a OH
    2117 CMe NMe Q1w a bond Me a bond NH S a bond Q3b OH
    2118 CMe NMe Q1w a bond Me a bond NH S a bond Q3c OH
    2119 CMe NMe Q1w a bond Me a bond NH O NH Q3a OH
    2120 CMe NMe Q1w a bond Me a bond NH O NH Q3b OH
    2121 CMe NMe Q1w a bond Me a bond NH O NH Q3c OH
    2122 CMe NMe Q1w a bond Me a bond NH O a bond Q3a OH
    2123 CMe NMe Q1w a bond Me a bond NH O a bond Q3b OH
    2124 CMe NMe Q1w a bond Me a bond NH O a bond Q3c OH
    2125 CMe NMe Q1w a bond H a bond NH S NH Q3a OH
    2126 CMe NMe Q1w a bond H a bond NH S NH Q3b OH
    2127 CMe NMe Q1w a bond H a bond NH S NH Q3c OH
    2128 CMe NMe Q1w a bond H a bond NH S a bond Q3a OH
    2129 CMe NMe Q1w a bond H a bond NH S a bond Q3b OH
    2130 CMe NMe Q1w a bond H a bond NH S a bond Q3c OH
    2131 CMe NMe Q1w a bond H a bond NH O NH Q3a OH
    2132 CMe NMe Q1w a bond H a bond NH O NH Q3b OH
    2133 CMe NMe Q1w a bond H a bond NH O NH Q3c OH
    2134 CMe NMe Q1w a bond H a bond NH O a bond Q3a OH
    2135 CMe NMe Q1w a bond H a bond NH O a bond Q3b OH
    2136 CMe NMe Q1w a bond H a bond NH O a bond Q3c OH
    2137 CMe NMe Q1x a bond Me a bond NH S NH Q3a OH
    2138 CMe NMe Q1x a bond Me a bond NH S NH Q3b OH
    2139 CMe NMe Q1x a bond Me a bond NH S NH Q3c OH
    2140 CMe NMe Q1x a bond Me a bond NH S a bond Q3a OH
    2141 CMe NMe Q1x a bond Me a bond NH S a bond Q3b OH
    2142 CMe NMe Q1x a bond Me a bond NH S a bond Q3c OH
    2143 CMe NMe Q1x a bond Me a bond NH O NH Q3a OH
    2144 CMe NMe Q1x a bond Me a bond NH O NH Q3b OH
    2145 CMe NMe Q1x a bond Me a bond NH O NH Q3c OH
    2146 CMe NMe Q1x a bond Me a bond NH O a bond Q3a OH
    2147 CMe NMe Q1x a bond Me a bond NH O a bond Q3b OH
    2148 CMe NMe Q1x a bond Me a bond NH O a bond Q3c OH
    2149 CMe NMe Q1x a bond H a bond NH S NH Q3a OH
    2150 CMe NMe Q1x a bond H a bond NH S NH Q3b OH
    2151 CMe NMe Q1x a bond H a bond NH S NH Q3c OH
    2152 CMe NMe Q1x a bond H a bond NH S a bond Q3a OH
    2153 CMe NMe Q1x a bond H a bond NH S a bond Q3b OH
    2154 CMe NMe Q1x a bond H a bond NH S a bond Q3c OH
    2155 CMe NMe Q1x a bond H a bond NH O NH Q3a OH
    2156 CMe NMe Q1x a bond H a bond NH O NH Q3b OH
    2157 CMe NMe Q1x a bond H a bond NH O NH Q3c OH
    2158 CMe NMe Q1x a bond H a bond NH O a bond Q3a OH
    2159 CMe NMe Q1x a bond H a bond NH O a bond Q3b OH
    2160 CMe NMe Q1x a bond H a bond NH O a bond Q3c OH
    2161 CMe NEt Q1o a bond Me a bond NH S NH Q3a OH
    2162 CMe NEt Q1o a bond Me a bond NH S NH Q3b OH
    2163 CMe NEt Q1o a bond Me a bond NH S NH Q3c OH
    2164 CMe NEt Q1o a bond Me a bond NH S a bond Q3a OH
    2165 CMe NEt Q1o a bond Me a bond NH S a bond Q3b OH
    2166 CMe NEt Q1o a bond Me a bond NH S a bond Q3c OH
    2167 CMe NEt Q1o a bond Me a bond NH O NH Q3a OH
    2168 CMe NEt Q1o a bond Me a bond NH O NH Q3b OH
    2169 CMe NEt Q1o a bond Me a bond NH O NH Q3c OH
    2170 CMe NEt Q1o a bond Me a bond NH O a bond Q3a OH
    2171 CMe NEt Q1o a bond Me a bond NH O a bond Q3b OH
    2172 CMe NEt Q1o a bond Me a bond NH O a bond Q3c OH
    2173 CMe NEt Q1o a bond H a bond NH S NH Q3a OH
    2174 CMe NEt Q1o a bond H a bond NH S NH Q3b OH
    2175 CMe NEt Q1o a bond H a bond NH S NH Q3c OH
    2176 CMe NEt Q1o a bond H a bond NH S a bond Q3a OH
    2177 CMe NEt Q1o a bond H a bond NH S a bond Q3b OH
    2178 CMe NEt Q1o a bond H a bond NH S a bond Q3c OH
    2179 CMe NEt Q1o a bond H a bond NH O NH Q3a OH
    2180 CMe NEt Q1o a bond H a bond NH O NH Q3b OH
    2181 CMe NEt Q1o a bond H a bond NH O NH Q3c OH
    2182 CMe NEt Q1o a bond H a bond NH O a bond Q3a OH
    2183 CMe NEt Q1o a bond H a bond NH O a bond Q3b OH
    2184 CMe NEt Q1o a bond H a bond NH O a bond Q3c OH
    2185 CMe NEt Q1p a bond Me a bond NH S NH Q3a OH
    2186 CMe NEt Q1p a bond Me a bond NH S NH Q3b OH
    2187 CMe NEt Q1p a bond Me a bond NH S NH Q3c OH
    2188 CMe NEt Q1p a bond Me a bond NH S a bond Q3a OH
    2189 CMe NEt Q1p a bond Me a bond NH S a bond Q3b OH
    2190 CMe NEt Q1p a bond Me a bond NH S a bond Q3c OH
    2191 CMe NEt Q1p a bond Me a bond NH O NH Q3a OH
    2192 CMe NEt Q1p a bond Me a bond NH O NH Q3b OH
    2193 CMe NEt Q1p a bond Me a bond NH O NH Q3c OH
    2194 CMe NEt Q1p a bond Me a bond NH O a bond Q3a OH
    2195 CMe NEt Q1p a bond Me a bond NH O a bond Q3b OH
    2196 CMe NEt Q1p a bond Me a bond NH O a bond Q3c OH
    2197 CMe NEt Q1p a bond H a bond NH S NH Q3a OH
    2198 CMe NEt Q1p a bond H a bond NH S NH Q3b OH
    2199 CMe NEt Q1p a bond H a bond NH S NH Q3c OH
    2200 CMe NEt Q1p a bond H a bond NH S a bond Q3a OH
    2201 CMe NEt Q1p a bond H a bond NH S a bond Q3b OH
    2202 CMe NEt Q1p a bond H a bond NH S a bond Q3c OH
    2203 CMe NEt Q1p a bond H a bond NH O NH Q3a OH
    2204 CMe NEt Q1p a bond H a bond NH O NH Q3b OH
    2205 CMe NEt Q1p a bond H a bond NH O NH Q3c OH
    2206 CMe NEt Q1p a bond H a bond NH O a bond Q3a OH
    2207 CMe NEt Q1p a bond H a bond NH O a bond Q3b OH
    2208 CMe NEt Q1p a bond H a bond NH O a bond Q3c OH
    2209 CMe NEt Q1q a bond Me a bond NH S NH Q3a OH
    2210 CMe NEt Q1q a bond Me a bond NH S NH Q3b OH
    2211 CMe NEt Q1q a bond Me a bond NH S NH Q3c OH
    2212 CMe NEt Q1q a bond Me a bond NH S a bond Q3a OH
    2213 CMe NEt Q1q a bond Me a bond NH S a bond Q3b OH
    2214 CMe NEt Q1q a bond Me a bond NH S a bond Q3c OH
    2215 CMe NEt Q1q a bond Me a bond NH O NH Q3a OH
    2216 CMe NEt Q1q a bond Me a bond NH O NH Q3b OH
    2217 CMe NEt Q1q a bond Me a bond NH O NH Q3c OH
    2218 CMe NEt Q1q a bond Me a bond NH O a bond Q3a OH
    2219 CMe NEt Q1q a bond Me a bond NH O a bond Q3b OH
    2220 CMe NEt Q1q a bond Me a bond NH O a bond Q3c OH
    2221 CMe NEt Q1q a bond H a bond NH S NH Q3a OH
    2222 CMe NEt Q1q a bond H a bond NH S NH Q3b OH
    2223 CMe NEt Q1q a bond H a bond NH S NH Q3c OH
    2224 CMe NEt Q1q a bond H a bond NH S a bond Q3a OH
    2225 CMe NEt Q1q a bond H a bond NH S a bond Q3b OH
    2226 CMe NEt Q1q a bond H a bond NH S a bond Q3c OH
    2227 CMe NEt Q1q a bond H a bond NH O NH Q3a OH
    2228 CMe NEt Q1q a bond H a bond NH O NH Q3b OH
    2229 CMe NEt Q1q a bond H a bond NH O NH Q3c OH
    2230 CMe NEt Q1q a bond H a bond NH O a bond Q3a OH
    2231 CMe NEt Q1q a bond H a bond NH O a bond Q3b OH
    2232 CMe NEt Q1q a bond H a bond NH O a bond Q3c OH
    2233 CMe NEt Q1r a bond Me a bond NH S NH Q3a OH
    2234 CMe NEt Q1r a bond Me a bond NH S NH Q3b OH
    2235 CMe NEt Q1r a bond Me a bond NH S NH Q3c OH
    2236 CMe NEt Q1r a bond Me a bond NH S a bond Q3a OH
    2237 CMe NEt Q1r a bond Me a bond NH S a bond Q3b OH
    2238 CMe NEt Q1r a bond Me a bond NH S a bond Q3c OH
    2239 CMe NEt Q1r a bond Me a bond NH O NH Q3a OH
    2240 CMe NEt Q1r a bond Me a bond NH O NH Q3b OH
    2241 CMe NEt Q1r a bond Me a bond NH O NH Q3c OH
    2242 CMe NEt Q1r a bond Me a bond NH O a bond Q3a OH
    2243 CMe NEt Q1r a bond Me a bond NH O a bond Q3b OH
    2244 CMe NEt Q1r a bond Me a bond NH O a bond Q3c OH
    2245 CMe NEt Q1r a bond H a bond NH S NH Q3a OH
    2246 CMe NEt Q1r a bond H a bond NH S NH Q3b OH
    2247 CMe NEt Q1r a bond H a bond NH S NH Q3c OH
    2248 CMe NEt Q1r a bond H a bond NH S a bond Q3a OH
    2249 CMe NEt Q1r a bond H a bond NH S a bond Q3b OH
    2250 CMe NEt Q1r a bond H a bond NH S a bond Q3c OH
    2251 CMe NEt Q1r a bond H a bond NH O NH Q3a OH
    2252 CMe NEt Q1r a bond H a bond NH O NH Q3b OH
    2253 CMe NEt Q1r a bond H a bond NH O NH Q3c OH
    2254 CMe NEt Q1r a bond H a bond NH O a bond Q3a OH
    2255 CMe NEt Q1r a bond H a bond NH O a bond Q3b OH
    2256 CMe NEt Q1r a bond H a bond NH O a bond Q3c OH
    2257 CMe NEt Q1s a bond Me a bond NH S NH Q3a OH
    2258 CMe NEt Q1s a bond Me a bond NH S NH Q3b OH
    2259 CMe NEt Q1s a bond Me a bond NH S NH Q3c OH
    2260 CMe NEt Q1s a bond Me a bond NH S a bond Q3a OH
    2261 CMe NEt Q1s a bond Me a bond NH S a bond Q3b OH
    2262 CMe NEt Q1s a bond Me a bond NH S a bond Q3c OH
    2263 CMe NEt Q1s a bond Me a bond NH O NH Q3a OH
    2264 CMe NEt Q1s a bond Me a bond NH O NH Q3b OH
    2265 CMe NEt Q1s a bond Me a bond NH O NH Q3c OH
    2266 CMe NEt Q1s a bond Me a bond NH O a bond Q3a OH
    2267 CMe NEt Q1s a bond Me a bond NH O a bond Q3b OH
    2268 CMe NEt Q1s a bond Me a bond NH O a bond Q3c OH
    2269 CMe NEt Q1s a bond H a bond NH S NH Q3a OH
    2270 CMe NEt Q1s a bond H a bond NH S NH Q3b OH
    2271 CMe NEt Q1s a bond H a bond NH S NH Q3c OH
    2272 CMe NEt Q1s a bond H a bond NH S a bond Q3a OH
    2273 CMe NEt Q1s a bond H a bond NH S a bond Q3b OH
    2274 CMe NEt Q1s a bond H a bond NH S a bond Q3c OH
    2275 CMe NEt Q1s a bond H a bond NH O NH Q3a OH
    2276 CMe NEt Q1s a bond H a bond NH O NH Q3b OH
    2277 CMe NEt Q1s a bond H a bond NH O NH Q3c OH
    2278 CMe NEt Q1s a bond H a bond NH O a bond Q3a OH
    2279 CMe NEt Q1s a bond H a bond NH O a bond Q3b OH
    2280 CMe NEt Q1s a bond H a bond NH O a bond Q3c OH
    2281 CMe NEt Q1t a bond Me a bond NH S NH Q3a OH
    2282 CMe NEt Q1t a bond Me a bond NH S NH Q3b OH
    2283 CMe NEt Q1t a bond Me a bond NH S NH Q3c OH
    2284 CMe NEt Q1t a bond Me a bond NH S a bond Q3a OH
    2285 CMe NEt Q1t a bond Me a bond NH S a bond Q3b OH
    2286 CMe NEt Q1t a bond Me a bond NH S a bond Q3c OH
    2287 CMe NEt Q1t a bond Me a bond NH O NH Q3a OH
    2288 CMe NEt Q1t a bond Me a bond NH O NH Q3b OH
    2289 CMe NEt Q1t a bond Me a bond NH O NH Q3c OH
    2290 CMe NEt Q1t a bond Me a bond NH O a bond Q3a OH
    2291 CMe NEt Q1t a bond Me a bond NH O a bond Q3b OH
    2292 CMe NEt Q1t a bond Me a bond NH O a bond Q3c OH
    2293 CMe NEt Q1t a bond H a bond NH S NH Q3a OH
    2294 CMe NEt Q1t a bond H a bond NH S NH Q3b OH
    2295 CMe NEt Q1t a bond H a bond NH S NH Q3c OH
    2296 CMe NEt Q1t a bond H a bond NH S a bond Q3a OH
    2297 CMe NEt Q1t a bond H a bond NH S a bond Q3b OH
    2298 CMe NEt Q1t a bond H a bond NH S a bond Q3c OH
    2299 CMe NEt Q1t a bond H a bond NH O NH Q3a OH
    2300 CMe NEt Q1t a bond H a bond NH O NH Q3b OH
    2301 CMe NEt Q1t a bond H a bond NH O NH Q3c OH
    2302 CMe NEt Q1t a bond H a bond NH O a bond Q3a OH
    2303 CMe NEt Q1t a bond H a bond NH O a bond Q3b OH
    2304 CMe NEt Q1t a bond H a bond NH O a bond Q3c OH
    2305 CMe NEt Q1u a bond Me a bond NH S NH Q3a OH
    2306 CMe NEt Q1u a bond Me a bond NH S NH Q3b OH
    2307 CMe NEt Q1u a bond Me a bond NH S NH Q3c OH
    2308 CMe NEt Q1u a bond Me a bond NH S a bond Q3a OH
    2309 CMe NEt Q1u a bond Me a bond NH S a bond Q3b OH
    2310 CMe NEt Q1u a bond Me a bond NH S a bond Q3c OH
    2311 CMe NEt Q1u a bond Me a bond NH O NH Q3a OH
    2312 CMe NEt Q1u a bond Me a bond NH O NH Q3b OH
    2313 CMe NEt Q1u a bond Me a bond NH O NH Q3c OH
    2314 CMe NEt Q1u a bond Me a bond NH O a bond Q3a OH
    2315 CMe NEt Q1u a bond Me a bond NH O a bond Q3b OH
    2316 CMe NEt Q1u a bond Me a bond NH O a bond Q3c OH
    2317 CMe NEt Q1u a bond H a bond NH S NH Q3a OH
    2318 CMe NEt Q1u a bond H a bond NH S NH Q3b OH
    2319 CMe NEt Q1u a bond H a bond NH S NH Q3c OH
    2320 CMe NEt Q1u a bond H a bond NH S a bond Q3a OH
    2321 CMe NEt Q1u a bond H a bond NH S a bond Q3b OH
    2322 CMe NEt Q1u a bond H a bond NH S a bond Q3c OH
    2323 CMe NEt Q1u a bond H a bond NH O NH Q3a OH
    2324 CMe NEt Q1u a bond H a bond NH O NH Q3b OH
    2325 CMe NEt Q1u a bond H a bond NH O NH Q3c OH
    2326 CMe NEt Q1u a bond H a bond NH O a bond Q3a OH
    2327 CMe NEt Q1u a bond H a bond NH O a bond Q3b OH
    2328 CMe NEt Q1u a bond H a bond NH O a bond Q3c OH
    2329 CMe NEt Q1v a bond Me a bond NH S NH Q3a OH
    2330 CMe NEt Q1v a bond Me a bond NH S NH Q3b OH
    2331 CMe NEt Q1v a bond Me a bond NH S NH Q3c OH
    2332 CMe NEt Q1v a bond Me a bond NH S a bond Q3a OH
    2333 CMe NEt Q1v a bond Me a bond NH S a bond Q3b OH
    2334 CMe NEt Q1v a bond Me a bond NH S a bond Q3c OH
    2335 CMe NEt Q1v a bond Me a bond NH O NH Q3a OH
    2336 CMe NEt Q1v a bond Me a bond NH O NH Q3b OH
    2337 CMe NEt Q1v a bond Me a bond NH O NH Q3c OH
    2338 CMe NEt Q1v a bond Me a bond NH O a bond Q3a OH
    2339 CMe NEt Q1v a bond Me a bond NH O a bond Q3b OH
    2340 CMe NEt Q1v a bond Me a bond NH O a bond Q3c OH
    2341 CMe NEt Q1v a bond H a bond NH S NH Q3a OH
    2342 CMe NEt Q1v a bond H a bond NH S NH Q3b OH
    2343 CMe NEt Q1v a bond H a bond NH S NH Q3c OH
    2344 CMe NEt Q1v a bond H a bond NH S a bond Q3a OH
    2345 CMe NEt Q1v a bond H a bond NH S a bond Q3b OH
    2346 CMe NEt Q1v a bond H a bond NH S a bond Q3c OH
    2347 CMe NEt Q1v a bond H a bond NH O NH Q3a OH
    2348 CMe NEt Q1v a bond H a bond NH O NH Q3b OH
    2349 CMe NEt Q1v a bond H a bond NH O NH Q3c OH
    2350 CMe NEt Q1v a bond H a bond NH O a bond Q3a OH
    2351 CMe NEt Q1v a bond H a bond NH O a bond Q3b OH
    2352 CMe NEt Q1v a bond H a bond NH O a bond Q3c OH
    2353 CMe NEt Q1w a bond Me a bond NH S NH Q3a OH
    2354 CMe NEt Q1w a bond Me a bond NH S NH Q3b OH
    2355 CMe NEt Q1w a bond Me a bond NH S NH Q3c OH
    2356 CMe NEt Q1w a bond Me a bond NH S a bond Q3a OH
    2357 CMe NEt Q1w a bond Me a bond NH S a bond Q3b OH
    2358 CMe NEt Q1w a bond Me a bond NH S a bond Q3c OH
    2359 CMe NEt Q1w a bond Me a bond NH O NH Q3a OH
    2360 CMe NEt Q1w a bond Me a bond NH O NH Q3b OH
    2361 CMe NEt Q1w a bond Me a bond NH O NH Q3c OH
    2362 CMe NEt Q1w a bond Me a bond NH O a bond Q3a OH
    2363 CMe NEt Q1w a bond Me a bond NH O a bond Q3b OH
    2364 CMe NEt Q1w a bond Me a bond NH O a bond Q3c OH
    2365 CMe NEt Q1w a bond H a bond NH S NH Q3a OH
    2366 CMe NEt Q1w a bond H a bond NH S NH Q3b OH
    2367 CMe NEt Q1w a bond H a bond NH S NH Q3c OH
    2368 CMe NEt Q1w a bond H a bond NH S a bond Q3a OH
    2369 CMe NEt Q1w a bond H a bond NH S a bond Q3b OH
    2370 CMe NEt Q1w a bond H a bond NH S a bond Q3c OH
    2371 CMe NEt Q1w a bond H a bond NH O NH Q3a OH
    2372 CMe NEt Q1w a bond H a bond NH O NH Q3b OH
    2373 CMe NEt Q1w a bond H a bond NH O NH Q3c OH
    2374 CMe NEt Q1w a bond H a bond NH O a bond Q3a OH
    2375 CMe NEt Q1w a bond H a bond NH O a bond Q3b OH
    2376 CMe NEt Q1w a bond H a bond NH O a bond Q3c OH
    2377 CMe NEt Q1x a bond Me a bond NH S NH Q3a OH
    2378 CMe NEt Q1x a bond Me a bond NH S NH Q3b OH
    2379 CMe NEt Q1x a bond Me a bond NH S NH Q3c OH
    2380 CMe NEt Q1x a bond Me a bond NH S a bond Q3a OH
    2381 CMe NEt Q1x a bond Me a bond NH S a bond Q3b OH
    2382 CMe NEt Q1x a bond Me a bond NH S a bond Q3c OH
    2383 CMe NEt Q1x a bond Me a bond NH O NH Q3a OH
    2384 CMe NEt Q1x a bond Me a bond NH O NH Q3b OH
    2385 CMe NEt Q1x a bond Me a bond NH O NH Q3c OH
    2386 CMe NEt Q1x a bond Me a bond NH O a bond Q3a OH
    2387 CMe NEt Q1x a bond Me a bond NH O a bond Q3b OH
    2388 CMe NEt Q1x a bond Me a bond NH O a bond Q3c OH
    2389 CMe NEt Q1x a bond H a bond NH S NH Q3a OH
    2390 CMe NEt Q1x a bond H a bond NH S NH Q3b OH
    2391 CMe NEt Q1x a bond H a bond NH S NH Q3c OH
    2392 CMe NEt Q1x a bond H a bond NH S a bond Q3a OH
    2393 CMe NEt Q1x a bond H a bond NH S a bond Q3b OH
    2394 CMe NEt Q1x a bond H a bond NH S a bond Q3c OH
    2395 CMe NEt Q1x a bond H a bond NH O NH Q3a OH
    2396 CMe NEt Q1x a bond H a bond NH O NH Q3b OH
    2397 CMe NEt Q1x a bond H a bond NH O NH Q3c OH
    2398 CMe NEt Q1x a bond H a bond NH O a bond Q3a OH
    2399 CMe NEt Q1x a bond H a bond NH O a bond Q3b OH
    2400 CMe NEt Q1x a bond H a bond NH O a bond Q3c OH
    2401 CMe S Q1o a bond Me a bond NH S NH Q3a OH
    2402 CMe S Q1o a bond Me a bond NH S NH Q3b OH
    2403 CMe S Q1o a bond Me a bond NH S NH Q3c OH
    2404 CMe S Q1o a bond Me a bond NH S a bond Q3a OH
    2405 CMe S Q1o a bond Me a bond NH S a bond Q3b OH
    2406 CMe S Q1o a bond Me a bond NH S a bond Q3c OH
    2407 CMe S Q1o a bond Me a bond NH O NH Q3a OH
    2408 CMe S Q1o a bond Me a bond NH O NH Q3b OH
    2409 CMe S Q1o a bond Me a bond NH O NH Q3c OH
    2410 CMe S Q1o a bond Me a bond NH O a bond Q3a OH
    2411 CMe S Q1o a bond Me a bond NH O a bond Q3b OH
    2412 CMe S Q1o a bond Me a bond NH O a bond Q3c OH
    2413 CMe S Q1o a bond H a bond NH S NH Q3a OH
    2414 CMe S Q1o a bond H a bond NH S NH Q3b OH
    2415 CMe S Q1o a bond H a bond NH S NH Q3c OH
    2416 CMe S Q1o a bond H a bond NH S a bond Q3a OH
    2417 CMe S Q1o a bond H a bond NH S a bond Q3b OH
    2418 CMe S Q1o a bond H a bond NH S a bond Q3c OH
    2419 CMe S Q1o a bond H a bond NH O NH Q3a OH
    2420 CMe S Q1o a bond H a bond NH O NH Q3b OH
    2421 CMe S Q1o a bond H a bond NH O NH Q3c OH
    2422 CMe S Q1o a bond H a bond NH O a bond Q3a OH
    2423 CMe S Q1o a bond H a bond NH O a bond Q3b OH
    2424 CMe S Q1o a bond H a bond NH O a bond Q3c OH
    2425 CMe S Q1p a bond Me a bond NH S NH Q3a OH
    2426 CMe S Q1p a bond Me a bond NH S NH Q3b OH
    2427 CMe S Q1p a bond Me a bond NH S NH Q3c OH
    2428 CMe S Q1p a bond Me a bond NH S a bond Q3a OH
    2429 CMe S Q1p a bond Me a bond NH S a bond Q3b OH
    2430 CMe S Q1p a bond Me a bond NH S a bond Q3c OH
    2431 CMe S Q1p a bond Me a bond NH O NH Q3a OH
    2432 CMe S Q1p a bond Me a bond NH O NH Q3b OH
    2433 CMe S Q1p a bond Me a bond NH O NH Q3c OH
    2434 CMe S Q1p a bond Me a bond NH O a bond Q3a OH
    2435 CMe S Q1p a bond Me a bond NH O a bond Q3b OH
    2436 CMe S Q1p a bond Me a bond NH O a bond Q3c OH
    2437 CMe S Q1p a bond H a bond NH S NH Q3a OH
    2438 CMe S Q1p a bond H a bond NH S NH Q3b OH
    2439 CMe S Q1p a bond H a bond NH S NH Q3c OH
    2440 CMe S Q1p a bond H a bond NH S a bond Q3a OH
    2441 CMe S Q1p a bond H a bond NH S a bond Q3b OH
    2442 CMe S Q1p a bond H a bond NH S a bond Q3c OH
    2443 CMe S Q1p a bond H a bond NH O NH Q3a OH
    2444 CMe S Q1p a bond H a bond NH O NH Q3b OH
    2445 CMe S Q1p a bond H a bond NH O NH Q3c OH
    2446 CMe S Q1p a bond H a bond NH O a bond Q3a OH
    2447 CMe S Q1p a bond H a bond NH O a bond Q3b OH
    2448 CMe S Q1p a bond H a bond NH O a bond Q3c OH
    2449 CMe S Q1q a bond Me a bond NH S NH Q3a OH
    2450 CMe S Q1q a bond Me a bond NH S NH Q3b OH
    2451 CMe S Q1q a bond Me a bond NH S NH Q3c OH
    2452 CMe S Q1q a bond Me a bond NH S a bond Q3a OH
    2453 CMe S Q1q a bond Me a bond NH S a bond Q3b OH
    2454 CMe S Q1q a bond Me a bond NH S a bond Q3c OH
    2455 CMe S Q1q a bond Me a bond NH O NH Q3a OH
    2456 CMe S Q1q a bond Me a bond NH O NH Q3b OH
    2457 CMe S Q1q a bond Me a bond NH O NH Q3c OH
    2458 CMe S Q1q a bond Me a bond NH O a bond Q3a OH
    2459 CMe S Q1q a bond Me a bond NH O a bond Q3b OH
    2460 CMe S Q1q a bond Me a bond NH O a bond Q3c OH
    2461 CMe S Q1q a bond H a bond NH S NH Q3a OH
    2462 CMe S Q1q a bond H a bond NH S NH Q3b OH
    2463 CMe S Q1q a bond H a bond NH S NH Q3c OH
    2464 CMe S Q1q a bond H a bond NH S a bond Q3a OH
    2465 CMe S Q1q a bond H a bond NH S a bond Q3b OH
    2466 CMe S Q1q a bond H a bond NH S a bond Q3c OH
    2467 CMe S Q1q a bond H a bond NH O NH Q3a OH
    2468 CMe S Q1q a bond H a bond NH O NH Q3b OH
    2469 CMe S Q1q a bond H a bond NH O NH Q3c OH
    2470 CMe S Q1q a bond H a bond NH O a bond Q3a OH
    2471 CMe S Q1q a bond H a bond NH O a bond Q3b OH
    2472 CMe S Q1q a bond H a bond NH O a bond Q3c OH
    2473 CMe S Q1r a bond Me a bond NH S NH Q3a OH
    2474 CMe S Q1r a bond Me a bond NH S NH Q3b OH
    2475 CMe S Q1r a bond Me a bond NH S NH Q3c OH
    2476 CMe S Q1r a bond Me a bond NH S a bond Q3a OH
    2477 CMe S Q1r a bond Me a bond NH S a bond Q3b OH
    2478 CMe S Q1r a bond Me a bond NH S a bond Q3c OH
    2479 CMe S Q1r a bond Me a bond NH O NH Q3a OH
    2480 CMe S Q1r a bond Me a bond NH O NH Q3b OH
    2481 CMe S Q1r a bond Me a bond NH O NH Q3c OH
    2482 CMe S Q1r a bond Me a bond NH O a bond Q3a OH
    2483 CMe S Q1r a bond Me a bond NH O a bond Q3b OH
    2484 CMe S Q1r a bond Me a bond NH O a bond Q3c OH
    2485 CMe S Q1r a bond H a bond NH S NH Q3a OH
    2486 CMe S Q1r a bond H a bond NH S NH Q3b OH
    2487 CMe S Q1r a bond H a bond NH S NH Q3c OH
    2488 CMe S Q1r a bond H a bond NH S a bond Q3a OH
    2489 CMe S Q1r a bond H a bond NH S a bond Q3b OH
    2490 CMe S Q1r a bond H a bond NH S a bond Q3c OH
    2491 CMe S Q1r a bond H a bond NH O NH Q3a OH
    2492 CMe S Q1r a bond H a bond NH O NH Q3b OH
    2493 CMe S Q1r a bond H a bond NH O NH Q3c OH
    2494 CMe S Q1r a bond H a bond NH O a bond Q3a OH
    2495 CMe S Q1r a bond H a bond NH O a bond Q3b OH
    2496 CMe S Q1r a bond H a bond NH O a bond Q3c OH
    2497 CMe S Q1s a bond Me a bond NH S NH Q3a OH
    2498 CMe S Q1s a bond Me a bond NH S NH Q3b OH
    2499 CMe S Q1s a bond Me a bond NH S NH Q3c OH
    2500 CMe S Q1s a bond Me a bond NH S a bond Q3a OH
    2501 CMe S Q1s a bond Me a bond NH S a bond Q3b OH
    2502 CMe S Q1s a bond Me a bond NH S a bond Q3c OH
    2503 CMe S Q1s a bond Me a bond NH O NH Q3a OH
    2504 CMe S Q1s a bond Me a bond NH O NH Q3b OH
    2505 CMe S Q1s a bond Me a bond NH O NH Q3c OH
    2506 CMe S Q1s a bond Me a bond NH O a bond Q3a OH
    2507 CMe S Q1s a bond Me a bond NH O a bond Q3b OH
    2508 CMe S Q1s a bond Me a bond NH O a bond Q3c OH
    2509 CMe S Q1s a bond H a bond NH S NH Q3a OH
    2510 CMe S Q1s a bond H a bond NH S NH Q3b OH
    2511 CMe S Q1s a bond H a bond NH S NH Q3c OH
    2512 CMe S Q1s a bond H a bond NH S a bond Q3a OH
    2513 CMe S Q1s a bond H a bond NH S a bond Q3b OH
    2514 CMe S Q1s a bond H a bond NH S a bond Q3c OH
    2515 CMe S Q1s a bond H a bond NH O NH Q3a OH
    2516 CMe S Q1s a bond H a bond NH O NH Q3b OH
    2517 CMe S Q1s a bond H a bond NH O NH Q3c OH
    2518 CMe S Q1s a bond H a bond NH O a bond Q3a OH
    2519 CMe S Q1s a bond H a bond NH O a bond Q3b OH
    2520 CMe S Q1s a bond H a bond NH O a bond Q3c OH
    2521 CMe S Q1t a bond Me a bond NH S NH Q3a OH
    2522 CMe S Q1t a bond Me a bond NH S NH Q3b OH
    2523 CMe S Q1t a bond Me a bond NH S NH Q3c OH
    2524 CMe S Q1t a bond Me a bond NH S a bond Q3a OH
    2525 CMe S Q1t a bond Me a bond NH S a bond Q3b OH
    2526 CMe S Q1t a bond Me a bond NH S a bond Q3c OH
    2527 CMe S Q1t a bond Me a bond NH O NH Q3a OH
    2528 CMe S Q1t a bond Me a bond NH O NH Q3b OH
    2529 CMe S Q1t a bond Me a bond NH O NH Q3c OH
    2530 CMe S Q1t a bond Me a bond NH O a bond Q3a OH
    2531 CMe S Q1t a bond Me a bond NH O a bond Q3b OH
    2532 CMe S Q1t a bond Me a bond NH O a bond Q3c OH
    2533 CMe S Q1t a bond H a bond NH S NH Q3a OH
    2534 CMe S Q1t a bond H a bond NH S NH Q3b OH
    2535 CMe S Q1t a bond H a bond NH S NH Q3c OH
    2536 CMe S Q1t a bond H a bond NH S a bond Q3a OH
    2537 CMe S Q1t a bond H a bond NH S a bond Q3b OH
    2538 CMe S Q1t a bond H a bond NH S a bond Q3c OH
    2539 CMe S Q1t a bond H a bond NH O NH Q3a OH
    2540 CMe S Q1t a bond H a bond NH O NH Q3b OH
    2541 CMe S Q1t a bond H a bond NH O NH Q3c OH
    2542 CMe S Q1t a bond H a bond NH O a bond Q3a OH
    2543 CMe S Q1t a bond H a bond NH O a bond Q3b OH
    2544 CMe S Q1t a bond H a bond NH O a bond Q3c OH
    2545 CMe S Q1u a bond Me a bond NH S NH Q3a OH
    2546 CMe S Q1u a bond Me a bond NH S NH Q3b OH
    2547 CMe S Q1u a bond Me a bond NH S NH Q3c OH
    2548 CMe S Q1u a bond Me a bond NH S a bond Q3a OH
    2549 CMe S Q1u a bond Me a bond NH S a bond Q3b OH
    2550 CMe S Q1u a bond Me a bond NH S a bond Q3c OH
    2551 CMe S Q1u a bond Me a bond NH O NH Q3a OH
    2552 CMe S Q1u a bond Me a bond NH O NH Q3b OH
    2553 CMe S Q1u a bond Me a bond NH O NH Q3c OH
    2554 CMe S Q1u a bond Me a bond NH O a bond Q3a OH
    2555 CMe S Q1u a bond Me a bond NH O a bond Q3b OH
    2556 CMe S Q1u a bond Me a bond NH O a bond Q3c OH
    2557 CMe S Q1u a bond H a bond NH S NH Q3a OH
    2558 CMe S Q1u a bond H a bond NH S NH Q3b OH
    2559 CMe S Q1u a bond H a bond NH S NH Q3c OH
    2560 CMe S Q1u a bond H a bond NH S a bond Q3a OH
    2561 CMe S Q1u a bond H a bond NH S a bond Q3b OH
    2562 CMe S Q1u a bond H a bond NH S a bond Q3c OH
    2563 CMe S Q1u a bond H a bond NH O NH Q3a OH
    2564 CMe S Q1u a bond H a bond NH O NH Q3b OH
    2565 CMe S Q1u a bond H a bond NH O NH Q3c OH
    2566 CMe S Q1u a bond H a bond NH O a bond Q3a OH
    2567 CMe S Q1u a bond H a bond NH O a bond Q3b OH
    2568 CMe S Q1u a bond H a bond NH O a bond Q3c OH
    2569 CMe S Q1v a bond Me a bond NH S NH Q3a OH
    2570 CMe S Q1v a bond Me a bond NH S NH Q3b OH
    2571 CMe S Q1v a bond Me a bond NH S NH Q3c OH
    2572 CMe S Q1v a bond Me a bond NH S a bond Q3a OH
    2573 CMe S Q1v a bond Me a bond NH S a bond Q3b OH
    2574 CMe S Q1v a bond Me a bond NH S a bond Q3c OH
    2575 CMe S Q1v a bond Me a bond NH O NH Q3a OH
    2576 CMe S Q1v a bond Me a bond NH O NH Q3b OH
    2577 CMe S Q1v a bond Me a bond NH O NH Q3c OH
    2578 CMe S Q1v a bond Me a bond NH O a bond Q3a OH
    2579 CMe S Q1v a bond Me a bond NH O a bond Q3b OH
    2580 CMe S Q1v a bond Me a bond NH O a bond Q3c OH
    2581 CMe S Q1v a bond H a bond NH S NH Q3a OH
    2582 CMe S Q1v a bond H a bond NH S NH Q3b OH
    2583 CMe S Q1v a bond H a bond NH S NH Q3c OH
    2584 CMe S Q1v a bond H a bond NH S a bond Q3a OH
    2585 CMe S Q1v a bond H a bond NH S a bond Q3b OH
    2586 CMe S Q1v a bond H a bond NH S a bond Q3c OH
    2587 CMe S Q1v a bond H a bond NH O NH Q3a OH
    2588 CMe S Q1v a bond H a bond NH O NH Q3b OH
    2589 CMe S Q1v a bond H a bond NH O NH Q3c OH
    2590 CMe S Q1v a bond H a bond NH O a bond Q3a OH
    2591 CMe S Q1v a bond H a bond NH O a bond Q3b OH
    2592 CMe S Q1v a bond H a bond NH O a bond Q3c OH
    2593 CMe S Q1w a bond Me a bond NH S NH Q3a OH
    2594 CMe S Q1w a bond Me a bond NH S NH Q3b OH
    2595 CMe S Q1w a bond Me a bond NH S NH Q3c OH
    2596 CMe S Q1w a bond Me a bond NH S a bond Q3a OH
    2597 CMe S Q1w a bond Me a bond NH S a bond Q3b OH
    2598 CMe S Q1w a bond Me a bond NH S a bond Q3c OH
    2599 CMe S Q1w a bond Me a bond NH O NH Q3a OH
    2600 CMe S Q1w a bond Me a bond NH O NH Q3b OH
    2601 CMe S Q1w a bond Me a bond NH O NH Q3c OH
    2602 CMe S Q1w a bond Me a bond NH O a bond Q3a OH
    2603 CMe S Q1w a bond Me a bond NH O a bond Q3b OH
    2604 CMe S Q1w a bond Me a bond NH O a bond Q3c OH
    2605 CMe S Q1w a bond H a bond NH S NH Q3a OH
    2606 CMe S Q1w a bond H a bond NH S NH Q3b OH
    2607 CMe S Q1w a bond H a bond NH S NH Q3c OH
    2608 CMe S Q1w a bond H a bond NH S a bond Q3a OH
    2609 CMe S Q1w a bond H a bond NH S a bond Q3b OH
    2610 CMe S Q1w a bond H a bond NH S a bond Q3c OH
    2611 CMe S Q1w a bond H a bond NH O NH Q3a OH
    2612 CMe S Q1w a bond H a bond NH O NH Q3b OH
    2613 CMe S Q1w a bond H a bond NH O NH Q3c OH
    2614 CMe S Q1w a bond H a bond NH O a bond Q3a OH
    2615 CMe S Q1w a bond H a bond NH O a bond Q3b OH
    2616 CMe S Q1w a bond H a bond NH O a bond Q3c OH
    2617 CMe S Q1x a bond Me a bond NH S NH Q3a OH
    2618 CMe S Q1x a bond Me a bond NH S NH Q3b OH
    2619 CMe S Q1x a bond Me a bond NH S NH Q3c OH
    2620 CMe S Q1x a bond Me a bond NH S a bond Q3a OH
    2621 CMe S Q1x a bond Me a bond NH S a bond Q3b OH
    2622 CMe S Q1x a bond Me a bond NH S a bond Q3c OH
    2623 CMe S Q1x a bond Me a bond NH O NH Q3a OH
    2624 CMe S Q1x a bond Me a bond NH O NH Q3b OH
    2625 CMe S Q1x a bond Me a bond NH O NH Q3c OH
    2626 CMe S Q1x a bond Me a bond NH O a bond Q3a OH
    2627 CMe S Q1x a bond Me a bond NH O a bond Q3b OH
    2628 CMe S Q1x a bond Me a bond NH O a bond Q3c OH
    2629 CMe S Q1x a bond H a bond NH S NH Q3a OH
    2630 CMe S Q1x a bond H a bond NH S NH Q3b OH
    2631 CMe S Q1x a bond H a bond NH S NH Q3c OH
    2632 CMe S Q1x a bond H a bond NH S a bond Q3a OH
    2633 CMe S Q1x a bond H a bond NH S a bond Q3b OH
    2634 CMe S Q1x a bond H a bond NH S a bond Q3c OH
    2635 CMe S Q1x a bond H a bond NH O NH Q3a OH
    2636 CMe S Q1x a bond H a bond NH O NH Q3b OH
    2637 CMe S Q1x a bond H a bond NH O NH Q3c OH
    2638 CMe S Q1x a bond H a bond NH O a bond Q3a OH
    2639 CMe S Q1x a bond H a bond NH O a bond Q3b OH
    2640 CMe S Q1x a bond H a bond NH O a bond Q3c OH
    2641 CMe O Q1o a bond Me a bond NH S NH Q3a OH
    2642 CMe O Q1o a bond Me a bond NH S NH Q3b OH
    2643 CMe O Q1o a bond Me a bond NH S NH Q3c OH
    2644 CMe O Q1o a bond Me a bond NH S a bond Q3a OH
    2645 CMe O Q1o a bond Me a bond NH S a bond Q3b OH
    2646 CMe O Q1o a bond Me a bond NH S a bond Q3c OH
    2647 CMe O Q1o a bond Me a bond NH O NH Q3a OH
    2648 CMe O Q1o a bond Me a bond NH O NH Q3b OH
    2649 CMe O Q1o a bond Me a bond NH O NH Q3c OH
    2650 CMe O Q1o a bond Me a bond NH O a bond Q3a OH
    2651 CMe O Q1o a bond Me a bond NH O a bond Q3b OH
    2652 CMe O Q1o a bond Me a bond NH O a bond Q3c OH
    2653 CMe O Q1o a bond H a bond NH S NH Q3a OH
    2654 CMe O Q1o a bond H a bond NH S NH Q3b OH
    2655 CMe O Q1o a bond H a bond NH S NH Q3c OH
    2656 CMe O Q1o a bond H a bond NH S a bond Q3a OH
    2657 CMe O Q1o a bond H a bond NH S a bond Q3b OH
    2658 CMe O Q1o a bond H a bond NH S a bond Q3c OH
    2659 CMe O Q1o a bond H a bond NH O NH Q3a OH
    2660 CMe O Q1o a bond H a bond NH O NH Q3b OH
    2661 CMe O Q1o a bond H a bond NH O NH Q3c OH
    2662 CMe O Q1o a bond H a bond NH O a bond Q3a OH
    2663 CMe O Q1o a bond H a bond NH O a bond Q3b OH
    2664 CMe O Q1o a bond H a bond NH O a bond Q3c OH
    2665 CMe O Q1p a bond Me a bond NH S NH Q3a OH
    2666 CMe O Q1p a bond Me a bond NH S NH Q3b OH
    2667 CMe O Q1p a bond Me a bond NH S NH Q3c OH
    2668 CMe O Q1p a bond Me a bond NH S a bond Q3a OH
    2669 CMe O Q1p a bond Me a bond NH S a bond Q3b OH
    2670 CMe O Q1p a bond Me a bond NH S a bond Q3c OH
    2671 CMe O Q1p a bond Me a bond NH O NH Q3a OH
    2672 CMe O Q1p a bond Me a bond NH O NH Q3b OH
    2673 CMe O Q1p a bond Me a bond NH O NH Q3c OH
    2674 CMe O Q1p a bond Me a bond NH O a bond Q3a OH
    2675 CMe O Q1p a bond Me a bond NH O a bond Q3b OH
    2676 CMe O Q1p a bond Me a bond NH O a bond Q3c OH
    2677 CMe O Q1p a bond H a bond NH S NH Q3a OH
    2678 CMe O Q1p a bond H a bond NH S NH Q3b OH
    2679 CMe O Q1p a bond H a bond NH S NH Q3c OH
    2680 CMe O Q1p a bond H a bond NH S a bond Q3a OH
    2681 CMe O Q1p a bond H a bond NH S a bond Q3b OH
    2682 CMe O Q1p a bond H a bond NH S a bond Q3c OH
    2683 CMe O Q1p a bond H a bond NH O NH Q3a OH
    2684 CMe O Q1p a bond H a bond NH O NH Q3b OH
    2685 CMe O Q1p a bond H a bond NH O NH Q3c OH
    2686 CMe O Q1p a bond H a bond NH O a bond Q3a OH
    2687 CMe O Q1p a bond H a bond NH O a bond Q3b OH
    2688 CMe O Q1p a bond H a bond NH O a bond Q3c OH
    2689 CMe O Q1q a bond Me a bond NH S NH Q3a OH
    2690 CMe O Q1q a bond Me a bond NH S NH Q3b OH
    2691 CMe O Q1q a bond Me a bond NH S NH Q3c OH
    2692 CMe O Q1q a bond Me a bond NH S a bond Q3a OH
    2693 CMe O Q1q a bond Me a bond NH S a bond Q3b OH
    2694 CMe O Q1q a bond Me a bond NH S a bond Q3c OH
    2695 CMe O Q1q a bond Me a bond NH O NH Q3a OH
    2696 CMe O Q1q a bond Me a bond NH O NH Q3b OH
    2697 CMe O Q1q a bond Me a bond NH O NH Q3c OH
    2698 CMe O Q1q a bond Me a bond NH O a bond Q3a OH
    2699 CMe O Q1q a bond Me a bond NH O a bond Q3b OH
    2700 CMe O Q1q a bond Me a bond NH O a bond Q3c OH
    2701 CMe O Q1q a bond H a bond NH S NH Q3a OH
    2702 CMe O Q1q a bond H a bond NH S NH Q3b OH
    2703 CMe O Q1q a bond H a bond NH S NH Q3c OH
    2704 CMe O Q1q a bond H a bond NH S a bond Q3a OH
    2705 CMe O Q1q a bond H a bond NH S a bond Q3b OH
    2706 CMe O Q1q a bond H a bond NH S a bond Q3c OH
    2707 CMe O Q1q a bond H a bond NH O NH Q3a OH
    2708 CMe O Q1q a bond H a bond NH O NH Q3b OH
    2709 CMe O Q1q a bond H a bond NH O NH Q3c OH
    2710 CMe O Q1q a bond H a bond NH O a bond Q3a OH
    2711 CMe O Q1q a bond H a bond NH O a bond Q3b OH
    2712 CMe O Q1q a bond H a bond NH O a bond Q3c OH
    2713 CMe O Q1r a bond Me a bond NH S NH Q3a OH
    2714 CMe O Q1r a bond Me a bond NH S NH Q3b OH
    2715 CMe O Q1r a bond Me a bond NH S NH Q3c OH
    2716 CMe O Q1r a bond Me a bond NH S a bond Q3a OH
    2717 CMe O Q1r a bond Me a bond NH S a bond Q3b OH
    2718 CMe O Q1r a bond Me a bond NH S a bond Q3c OH
    2719 CMe O Q1r a bond Me a bond NH O NH Q3a OH
    2720 CMe O Q1r a bond Me a bond NH O NH Q3b OH
    2721 CMe O Q1r a bond Me a bond NH O NH Q3c OH
    2722 CMe O Q1r a bond Me a bond NH O a bond Q3a OH
    2723 CMe O Q1r a bond Me a bond NH O a bond Q3b OH
    2724 CMe O Q1r a bond Me a bond NH O a bond Q3c OH
    2725 CMe O Q1r a bond H a bond NH S NH Q3a OH
    2726 CMe O Q1r a bond H a bond NH S NH Q3b OH
    2727 CMe O Q1r a bond H a bond NH S NH Q3c OH
    2728 CMe O Q1r a bond H a bond NH S a bond Q3a OH
    2729 CMe O Q1r a bond H a bond NH S a bond Q3b OH
    2730 CMe O Q1r a bond H a bond NH S a bond Q3c OH
    2731 CMe O Q1r a bond H a bond NH O NH Q3a OH
    2732 CMe O Q1r a bond H a bond NH O NH Q3b OH
    2733 CMe O Q1r a bond H a bond NH O NH Q3c OH
    2734 CMe O Q1r a bond H a bond NH O a bond Q3a OH
    2735 CMe O Q1r a bond H a bond NH O a bond Q3b OH
    2736 CMe O Q1r a bond H a bond NH O a bond Q3c OH
    2737 CMe O Q1s a bond Me a bond NH S NH Q3a OH
    2738 CMe O Q1s a bond Me a bond NH S NH Q3b OH
    2739 CMe O Q1s a bond Me a bond NH S NH Q3c OH
    2740 CMe O Q1s a bond Me a bond NH S a bond Q3a OH
    2741 CMe O Q1s a bond Me a bond NH S a bond Q3b OH
    2742 CMe O Q1s a bond Me a bond NH S a bond Q3c OH
    2743 CMe O Q1s a bond Me a bond NH O NH Q3a OH
    2744 CMe O Q1s a bond Me a bond NH O NH Q3b OH
    2745 CMe O Q1s a bond Me a bond NH O NH Q3c OH
    2746 CMe O Q1s a bond Me a bond NH O a bond Q3a OH
    2747 CMe O Q1s a bond Me a bond NH O a bond Q3b OH
    2748 CMe O Q1s a bond Me a bond NH O a bond Q3c OH
    2749 CMe O Q1s a bond H a bond NH S NH Q3a OH
    2750 CMe O Q1s a bond H a bond NH S NH Q3b OH
    2751 CMe O Q1s a bond H a bond NH S NH Q3c OH
    2752 CMe O Q1s a bond H a bond NH S a bond Q3a OH
    2753 CMe O Q1s a bond H a bond NH S a bond Q3b OH
    2754 CMe O Q1s a bond H a bond NH S a bond Q3c OH
    2755 CMe O Q1s a bond H a bond NH O NH Q3a OH
    2756 CMe O Q1s a bond H a bond NH O NH Q3b OH
    2757 CMe O Q1s a bond H a bond NH O NH Q3c OH
    2758 CMe O Q1s a bond H a bond NH O a bond Q3a OH
    2759 CMe O Q1s a bond H a bond NH O a bond Q3b OH
    2760 CMe O Q1s a bond H a bond NH O a bond Q3c OH
    2761 CMe O Q1t a bond Me a bond NH S NH Q3a OH
    2762 CMe O Q1t a bond Me a bond NH S NH Q3b OH
    2763 CMe O Q1t a bond Me a bond NH S NH Q3c OH
    2764 CMe O Q1t a bond Me a bond NH S a bond Q3a OH
    2765 CMe O Q1t a bond Me a bond NH S a bond Q3b OH
    2766 CMe O Q1t a bond Me a bond NH S a bond Q3c OH
    2767 CMe O Q1t a bond Me a bond NH O NH Q3a OH
    2768 CMe O Q1t a bond Me a bond NH O NH Q3b OH
    2769 CMe O Q1t a bond Me a bond NH O NH Q3c OH
    2770 CMe O Q1t a bond Me a bond NH O a bond Q3a OH
    2771 CMe O Q1t a bond Me a bond NH O a bond Q3b OH
    2772 CMe O Q1t a bond Me a bond NH O a bond Q3c OH
    2773 CMe O Q1t a bond H a bond NH S NH Q3a OH
    2774 CMe O Q1t a bond H a bond NH S NH Q3b OH
    2775 CMe O Q1t a bond H a bond NH S NH Q3c OH
    2776 CMe O Q1t a bond H a bond NH S a bond Q3a OH
    2777 CMe O Q1t a bond H a bond NH S a bond Q3b OH
    2778 CMe O Q1t a bond H a bond NH S a bond Q3c OH
    2779 CMe O Q1t a bond H a bond NH O NH Q3a OH
    2780 CMe O Q1t a bond H a bond NH O NH Q3b OH
    2781 CMe O Q1t a bond H a bond NH O NH Q3c OH
    2782 CMe O Q1t a bond H a bond NH O a bond Q3a OH
    2783 CMe O Q1t a bond H a bond NH O a bond Q3b OH
    2784 CMe O Q1t a bond H a bond NH O a bond Q3c OH
    2785 CMe O Q1u a bond Me a bond NH S NH Q3a OH
    2786 CMe O Q1u a bond Me a bond NH S NH Q3b OH
    2787 CMe O Q1u a bond Me a bond NH S NH Q3c OH
    2788 CMe O Q1u a bond Me a bond NH S a bond Q3a OH
    2789 CMe O Q1u a bond Me a bond NH S a bond Q3b OH
    2790 CMe O Q1u a bond Me a bond NH S a bond Q3c OH
    2791 CMe O Q1u a bond Me a bond NH O NH Q3a OH
    2792 CMe O Q1u a bond Me a bond NH O NH Q3b OH
    2793 CMe O Q1u a bond Me a bond NH O NH Q3c OH
    2794 CMe O Q1u a bond Me a bond NH O a bond Q3a OH
    2795 CMe O Q1u a bond Me a bond NH O a bond Q3b OH
    2796 CMe O Q1u a bond Me a bond NH O a bond Q3c OH
    2797 CMe O Q1u a bond H a bond NH S NH Q3a OH
    2798 CMe O Q1u a bond H a bond NH S NH Q3b OH
    2799 CMe O Q1u a bond H a bond NH S NH Q3c OH
    2800 CMe O Q1u a bond H a bond NH S a bond Q3a OH
    2801 CMe O Q1u a bond H a bond NH S a bond Q3b OH
    2802 CMe O Q1u a bond H a bond NH S a bond Q3c OH
    2803 CMe O Q1u a bond H a bond NH O NH Q3a OH
    2804 CMe O Q1u a bond H a bond NH O NH Q3b OH
    2805 CMe O Q1u a bond H a bond NH O NH Q3c OH
    2806 CMe O Q1u a bond H a bond NH O a bond Q3a OH
    2807 CMe O Q1u a bond H a bond NH O a bond Q3b OH
    2808 CMe O Q1u a bond H a bond NH O a bond Q3c OH
    2809 CMe O Q1v a bond Me a bond NH S NH Q3a OH
    2810 CMe O Q1v a bond Me a bond NH S NH Q3b OH
    2811 CMe O Q1v a bond Me a bond NH S NH Q3c OH
    2812 CMe O Q1v a bond Me a bond NH S a bond Q3a OH
    2813 CMe O Q1v a bond Me a bond NH S a bond Q3b OH
    2814 CMe O Q1v a bond Me a bond NH S a bond Q3c OH
    2815 CMe O Q1v a bond Me a bond NH O NH Q3a OH
    2816 CMe O Q1v a bond Me a bond NH O NH Q3b OH
    2817 CMe O Q1v a bond Me a bond NH O NH Q3c OH
    2818 CMe O Q1v a bond Me a bond NH O a bond Q3a OH
    2819 CMe O Q1v a bond Me a bond NH O a bond Q3b OH
    2820 CMe O Q1v a bond Me a bond NH O a bond Q3c OH
    2821 CMe O Q1v a bond H a bond NH S NH Q3a OH
    2822 CMe O Q1v a bond H a bond NH S NH Q3b OH
    2823 CMe O Q1v a bond H a bond NH S NH Q3c OH
    2824 CMe O Q1v a bond H a bond NH S a bond Q3a OH
    2825 CMe O Q1v a bond H a bond NH S a bond Q3b OH
    2826 CMe O Q1v a bond H a bond NH S a bond Q3c OH
    2827 CMe O Q1v a bond H a bond NH O NH Q3a OH
    2828 CMe O Q1v a bond H a bond NH O NH Q3b OH
    2829 CMe O Q1v a bond H a bond NH O NH Q3c OH
    2830 CMe O Q1v a bond H a bond NH O a bond Q3a OH
    2831 CMe O Q1v a bond H a bond NH O a bond Q3b OH
    2832 CMe O Q1v a bond H a bond NH O a bond Q3c OH
    2833 CMe O Q1w a bond Me a bond NH S NH Q3a OH
    2834 CMe O Q1w a bond Me a bond NH S NH Q3b OH
    2835 CMe O Q1w a bond Me a bond NH S NH Q3c OH
    2836 CMe O Q1w a bond Me a bond NH S a bond Q3a OH
    2837 CMe O Q1w a bond Me a bond NH S a bond Q3b OH
    2838 CMe O Q1w a bond Me a bond NH S a bond Q3c OH
    2839 CMe O Q1w a bond Me a bond NH O NH Q3a OH
    2840 CMe O Q1w a bond Me a bond NH O NH Q3b OH
    2841 CMe O Q1w a bond Me a bond NH O NH Q3c OH
    2842 CMe O Q1w a bond Me a bond NH O a bond Q3a OH
    2843 CMe O Q1w a bond Me a bond NH O a bond Q3b OH
    2844 CMe O Q1w a bond Me a bond NH O a bond Q3c OH
    2845 CMe O Q1w a bond H a bond NH S NH Q3a OH
    2846 CMe O Q1w a bond H a bond NH S NH Q3b OH
    2847 CMe O Q1w a bond H a bond NH S NH Q3c OH
    2848 CMe O Q1w a bond H a bond NH S a bond Q3a OH
    2849 CMe O Q1w a bond H a bond NH S a bond Q3b OH
    2850 CMe O Q1w a bond H a bond NH S a bond Q3c OH
    2851 CMe O Q1w a bond H a bond NH O NH Q3a OH
    2852 CMe O Q1w a bond H a bond NH O NH Q3b OH
    2853 CMe O Q1w a bond H a bond NH O NH Q3c OH
    2854 CMe O Q1w a bond H a bond NH O a bond Q3a OH
    2855 CMe O Q1w a bond H a bond NH O a bond Q3b OH
    2856 CMe O Q1w a bond H a bond NH O a bond Q3c OH
    2857 CMe O Q1x a bond Me a bond NH S NH Q3a OH
    2858 CMe O Q1x a bond Me a bond NH S NH Q3b OH
    2859 CMe O Q1x a bond Me a bond NH S NH Q3c OH
    2860 CMe O Q1x a bond Me a bond NH S a bond Q3a OH
    2861 CMe O Q1x a bond Me a bond NH S a bond Q3b OH
    2862 CMe O Q1x a bond Me a bond NH S a bond Q3c OH
    2863 CMe O Q1x a bond Me a bond NH O NH Q3a OH
    2864 CMe O Q1x a bond Me a bond NH O NH Q3b OH
    2865 CMe O Q1x a bond Me a bond NH O NH Q3c OH
    2866 CMe O Q1x a bond Me a bond NH O a bond Q3a OH
    2867 CMe O Q1x a bond Me a bond NH O a bond Q3b OH
    2868 CMe O Q1x a bond Me a bond NH O a bond Q3c OH
    2869 CMe O Q1x a bond H a bond NH S NH Q3a OH
    2870 CMe O Q1x a bond H a bond NH S NH Q3b OH
    2871 CMe O Q1x a bond H a bond NH S NH Q3c OH
    2872 CMe O Q1x a bond H a bond NH S a bond Q3a OH
    2873 CMe O Q1x a bond H a bond NH S a bond Q3b OH
    2874 CMe O Q1x a bond H a bond NH S a bond Q3c OH
    2875 CMe O Q1x a bond H a bond NH O NH Q3a OH
    2876 CMe O Q1x a bond H a bond NH O NH Q3b OH
    2877 CMe O Q1x a bond H a bond NH O NH Q3c OH
    2878 CMe O Q1x a bond H a bond NH O a bond Q3a OH
    2879 CMe O Q1x a bond H a bond NH O a bond Q3b OH
    2880 CMe O Q1x a bond H a bond NH O a bond Q3c OH
    2881 CH NH Q1o a bond Me a bond NH S NH Q3a OH
    2882 CH NH Q1o a bond Me a bond NH S NH Q3b OH
    2883 CH NH Q1o a bond Me a bond NH S NH Q3c OH
    2884 CH NH Q1o a bond Me a bond NH S a bond Q3a OH
    2885 CH NH Q1o a bond Me a bond NH S a bond Q3b OH
    2886 CH NH Q1o a bond Me a bond NH S a bond Q3c OH
    2887 CH NH Q1o a bond Me a bond NH O NH Q3a OH
    2888 CH NH Q1o a bond Me a bond NH O NH Q3b OH
    2889 CH NH Q1o a bond Me a bond NH O NH Q3c OH
    2890 CH NH Q1o a bond Me a bond NH O a bond Q3a OH
    2891 CH NH Q1o a bond Me a bond NH O a bond Q3b OH
    2892 CH NH Q1o a bond Me a bond NH O a bond Q3c OH
    2893 CH NH Q1o a bond H a bond NH S NH Q3a OH
    2894 CH NH Q1o a bond H a bond NH S NH Q3b OH
    2895 CH NH Q1o a bond H a bond NH S NH Q3c OH
    2896 CH NH Q1o a bond H a bond NH S a bond Q3a OH
    2897 CH NH Q1o a bond H a bond NH S a bond Q3b OH
    2898 CH NH Q1o a bond H a bond NH S a bond Q3c OH
    2899 CH NH Q1o a bond H a bond NH O NH Q3a OH
    2900 CH NH Q1o a bond H a bond NH O NH Q3b OH
    2901 CH NH Q1o a bond H a bond NH O NH Q3c OH
    2902 CH NH Q1o a bond H a bond NH O a bond Q3a OH
    2903 CH NH Q1o a bond H a bond NH O a bond Q3b OH
    2904 CH NH Q1o a bond H a bond NH O a bond Q3c OH
    2905 CH NH Q1p a bond Me a bond NH S NH Q3a OH
    2906 CH NH Q1p a bond Me a bond NH S NH Q3b OH
    2907 CH NH Q1p a bond Me a bond NH S NH Q3c OH
    2908 CH NH Q1p a bond Me a bond NH S a bond Q3a OH
    2909 CH NH Q1p a bond Me a bond NH S a bond Q3b OH
    2910 CH NH Q1p a bond Me a bond NH S a bond Q3c OH
    2911 CH NH Q1p a bond Me a bond NH O NH Q3a OH
    2912 CH NH Q1p a bond Me a bond NH O NH Q3b OH
    2913 CH NH Q1p a bond Me a bond NH O NH Q3c OH
    2914 CH NH Q1p a bond Me a bond NH O a bond Q3a OH
    2915 CH NH Q1p a bond Me a bond NH O a bond Q3b OH
    2916 CH NH Q1p a bond Me a bond NH O a bond Q3c OH
    2917 CH NH Q1p a bond H a bond NH S NH Q3a OH
    2918 CH NH Q1p a bond H a bond NH S NH Q3b OH
    2919 CH NH Q1p a bond H a bond NH S NH Q3c OH
    2920 CH NH Q1p a bond H a bond NH S a bond Q3a OH
    2921 CH NH Q1p a bond H a bond NH S a bond Q3b OH
    2922 CH NH Q1p a bond H a bond NH S a bond Q3c OH
    2923 CH NH Q1p a bond H a bond NH O NH Q3a OH
    2924 CH NH Q1p a bond H a bond NH O NH Q3b OH
    2925 CH NH Q1p a bond H a bond NH O NH Q3c OH
    2926 CH NH Q1p a bond H a bond NH O a bond Q3a OH
    2927 CH NH Q1p a bond H a bond NH O a bond Q3b OH
    2928 CH NH Q1p a bond H a bond NH O a bond Q3c OH
    2929 CH NH Q1q a bond Me a bond NH S NH Q3a OH
    2930 CH NH Q1q a bond Me a bond NH S NH Q3b OH
    2931 CH NH Q1q a bond Me a bond NH S NH Q3c OH
    2932 CH NH Q1q a bond Me a bond NH S a bond Q3a OH
    2933 CH NH Q1q a bond Me a bond NH S a bond Q3b OH
    2934 CH NH Q1q a bond Me a bond NH S a bond Q3c OH
    2935 CH NH Q1q a bond Me a bond NH O NH Q3a OH
    2936 CH NH Q1q a bond Me a bond NH O NH Q3b OH
    2937 CH NH Q1q a bond Me a bond NH O NH Q3c OH
    2938 CH NH Q1q a bond Me a bond NH O a bond Q3a OH
    2939 CH NH Q1q a bond Me a bond NH O a bond Q3b OH
    2940 CH NH Q1q a bond Me a bond NH O a bond Q3c OH
    2941 CH NH Q1q a bond H a bond NH S NH Q3a OH
    2942 CH NH Q1q a bond H a bond NH S NH Q3b OH
    2943 CH NH Q1q a bond H a bond NH S NH Q3c OH
    2944 CH NH Q1q a bond H a bond NH S a bond Q3a OH
    2945 CH NH Q1q a bond H a bond NH S a bond Q3b OH
    2946 CH NH Q1q a bond H a bond NH S a bond Q3c OH
    2947 CH NH Q1q a bond H a bond NH O NH Q3a OH
    2948 CH NH Q1q a bond H a bond NH O NH Q3b OH
    2949 CH NH Q1q a bond H a bond NH O NH Q3c OH
    2950 CH NH Q1q a bond H a bond NH O a bond Q3a OH
    2951 CH NH Q1q a bond H a bond NH O a bond Q3b OH
    2952 CH NH Q1q a bond H a bond NH O a bond Q3c OH
    2953 CH NH Q1r a bond Me a bond NH S NH Q3a OH
    2954 CH NH Q1r a bond Me a bond NH S NH Q3b OH
    2955 CH NH Q1r a bond Me a bond NH S NH Q3c OH
    2956 CH NH Q1r a bond Me a bond NH S a bond Q3a OH
    2957 CH NH Q1r a bond Me a bond NH S a bond Q3b OH
    2958 CH NH Q1r a bond Me a bond NH S a bond Q3c OH
    2959 CH NH Q1r a bond Me a bond NH O NH Q3a OH
    2960 CH NH Q1r a bond Me a bond NH O NH Q3b OH
    2961 CH NH Q1r a bond Me a bond NH O NH Q3c OH
    2962 CH NH Q1r a bond Me a bond NH O a bond Q3a OH
    2963 CH NH Q1r a bond Me a bond NH O a bond Q3b OH
    2964 CH NH Q1r a bond Me a bond NH O a bond Q3c OH
    2965 CH NH Q1r a bond H a bond NH S NH Q3a OH
    2966 CH NH Q1r a bond H a bond NH S NH Q3b OH
    2967 CH NH Q1r a bond H a bond NH S NH Q3c OH
    2968 CH NH Q1r a bond H a bond NH S a bond Q3a OH
    2969 CH NH Q1r a bond H a bond NH S a bond Q3b OH
    2970 CH NH Q1r a bond H a bond NH S a bond Q3c OH
    2971 CH NH Q1r a bond H a bond NH O NH Q3a OH
    2972 CH NH Q1r a bond H a bond NH O NH Q3b OH
    2973 CH NH Q1r a bond H a bond NH O NH Q3c OH
    2974 CH NH Q1r a bond H a bond NH O a bond Q3a OH
    2975 CH NH Q1r a bond H a bond NH O a bond Q3b OH
    2976 CH NH Q1r a bond H a bond NH O a bond Q3c OH
    2977 CH NH Q1s a bond Me a bond NH S NH Q3a OH
    2978 CH NH Q1s a bond Me a bond NH S NH Q3b OH
    2979 CH NH Q1s a bond Me a bond NH S NH Q3c OH
    2980 CH NH Q1s a bond Me a bond NH S a bond Q3a OH
    2981 CH NH Q1s a bond Me a bond NH S a bond Q3b OH
    2982 CH NH Q1s a bond Me a bond NH S a bond Q3c OH
    2983 CH NH Q1s a bond Me a bond NH O NH Q3a OH
    2984 CH NH Q1s a bond Me a bond NH O NH Q3b OH
    2985 CH NH Q1s a bond Me a bond NH O NH Q3c OH
    2986 CH NH Q1s a bond Me a bond NH O a bond Q3a OH
    2987 CH NH Q1s a bond Me a bond NH O a bond Q3b OH
    2988 CH NH Q1s a bond Me a bond NH O a bond Q3c OH
    2989 CH NH Q1s a bond H a bond NH S NH Q3a OH
    2990 CH NH Q1s a bond H a bond NH S NH Q3b OH
    2991 CH NH Q1s a bond H a bond NH S NH Q3c OH
    2992 CH NH Q1s a bond H a bond NH S a bond Q3a OH
    2993 CH NH Q1s a bond H a bond NH S a bond Q3b OH
    2994 CH NH Q1s a bond H a bond NH S a bond Q3c OH
    2995 CH NH Q1s a bond H a bond NH O NH Q3a OH
    2996 CH NH Q1s a bond H a bond NH O NH Q3b OH
    2997 CH NH Q1s a bond H a bond NH O NH Q3c OH
    2998 CH NH Q1s a bond H a bond NH O a bond Q3a OH
    2999 CH NH Q1s a bond H a bond NH O a bond Q3b OH
    3000 CH NH Q1s a bond H a bond NH O a bond Q3c OH
    3001 CH NH Q1t a bond Me a bond NH S NH Q3a OH
    3002 CH NH Q1t a bond Me a bond NH S NH Q3b OH
    3003 CH NH Q1t a bond Me a bond NH S NH Q3c OH
    3004 CH NH Q1t a bond Me a bond NH S a bond Q3a OH
    3005 CH NH Q1t a bond Me a bond NH S a bond Q3b OH
    3006 CH NH Q1t a bond Me a bond NH S a bond Q3c OH
    3007 CH NH Q1t a bond Me a bond NH O NH Q3a OH
    3008 CH NH Q1t a bond Me a bond NH O NH Q3b OH
    3009 CH NH Q1t a bond Me a bond NH O NH Q3c OH
    3010 CH NH Q1t a bond Me a bond NH O a bond Q3a OH
    3011 CH NH Q1t a bond Me a bond NH O a bond Q3b OH
    3012 CH NH Q1t a bond Me a bond NH O a bond Q3c OH
    3013 CH NH Q1t a bond H a bond NH S NH Q3a OH
    3014 CH NH Q1t a bond H a bond NH S NH Q3b OH
    3015 CH NH Q1t a bond H a bond NH S NH Q3c OH
    3016 CH NH Q1t a bond H a bond NH S a bond Q3a OH
    3017 CH NH Q1t a bond H a bond NH S a bond Q3b OH
    3018 CH NH Q1t a bond H a bond NH S a bond Q3c OH
    3019 CH NH Q1t a bond H a bond NH O NH Q3a OH
    3020 CH NH Q1t a bond H a bond NH O NH Q3b OH
    3021 CH NH Q1t a bond H a bond NH O NH Q3c OH
    3022 CH NH Q1t a bond H a bond NH O a bond Q3a OH
    3023 CH NH Q1t a bond H a bond NH O a bond Q3b OH
    3024 CH NH Q1t a bond H a bond NH O a bond Q3c OH
    3025 CH NH Q1u a bond Me a bond NH S NH Q3a OH
    3026 CH NH Q1u a bond Me a bond NH S NH Q3b OH
    3027 CH NH Q1u a bond Me a bond NH S NH Q3c OH
    3028 CH NH Q1u a bond Me a bond NH S a bond Q3a OH
    3029 CH NH Q1u a bond Me a bond NH S a bond Q3b OH
    3030 CH NH Q1u a bond Me a bond NH S a bond Q3c OH
    3031 CH NH Q1u a bond Me a bond NH O NH Q3a OH
    3032 CH NH Q1u a bond Me a bond NH O NH Q3b OH
    3033 CH NH Q1u a bond Me a bond NH O NH Q3c OH
    3034 CH NH Q1u a bond Me a bond NH O a bond Q3a OH
    3035 CH NH Q1u a bond Me a bond NH O a bond Q3b OH
    3036 CH NH Q1u a bond Me a bond NH O a bond Q3c OH
    3037 CH NH Q1u a bond H a bond NH S NH Q3a OH
    3038 CH NH Q1u a bond H a bond NH S NH Q3b OH
    3039 CH NH Q1u a bond H a bond NH S NH Q3c OH
    3040 CH NH Q1u a bond H a bond NH S a bond Q3a OH
    3041 CH NH Q1u a bond H a bond NH S a bond Q3b OH
    3042 CH NH Q1u a bond H a bond NH S a bond Q3c OH
    3043 CH NH Q1u a bond H a bond NH O NH Q3a OH
    3044 CH NH Q1u a bond H a bond NH O NH Q3b OH
    3045 CH NH Q1u a bond H a bond NH O NH Q3c OH
    3046 CH NH Q1u a bond H a bond NH O a bond Q3a OH
    3047 CH NH Q1u a bond H a bond NH O a bond Q3b OH
    3048 CH NH Q1u a bond H a bond NH O a bond Q3c OH
    3049 CH NH Q1v a bond Me a bond NH S NH Q3a OH
    3050 CH NH Q1v a bond Me a bond NH S NH Q3b OH
    3051 CH NH Q1v a bond Me a bond NH S NH Q3c OH
    3052 CH NH Q1v a bond Me a bond NH S a bond Q3a OH
    3053 CH NH Q1v a bond Me a bond NH S a bond Q3b OH
    3054 CH NH Q1v a bond Me a bond NH S a bond Q3c OH
    3055 CH NH Q1v a bond Me a bond NH O NH Q3a OH
    3056 CH NH Q1v a bond Me a bond NH O NH Q3b OH
    3057 CH NH Q1v a bond Me a bond NH O NH Q3c OH
    3058 CH NH Q1v a bond Me a bond NH O a bond Q3a OH
    3059 CH NH Q1v a bond Me a bond NH O a bond Q3b OH
    3060 CH NH Q1v a bond Me a bond NH O a bond Q3c OH
    3061 CH NH Q1v a bond H a bond NH S NH Q3a OH
    3062 CH NH Q1v a bond H a bond NH S NH Q3b OH
    3063 CH NH Q1v a bond H a bond NH S NH Q3c OH
    3064 CH NH Q1v a bond H a bond NH S a bond Q3a OH
    3065 CH NH Q1v a bond H a bond NH S a bond Q3b OH
    3066 CH NH Q1v a bond H a bond NH S a bond Q3c OH
    3067 CH NH Q1v a bond H a bond NH O NH Q3a OH
    3068 CH NH Q1v a bond H a bond NH O NH Q3b OH
    3069 CH NH Q1v a bond H a bond NH O NH Q3c OH
    3070 CH NH Q1v a bond H a bond NH O a bond Q3a OH
    3071 CH NH Q1v a bond H a bond NH O a bond Q3b OH
    3072 CH NH Q1v a bond H a bond NH O a bond Q3c OH
    3073 CH NH Q1w a bond Me a bond NH S NH Q3a OH
    3074 CH NH Q1w a bond Me a bond NH S NH Q3b OH
    3075 CH NH Q1w a bond Me a bond NH S NH Q3c OH
    3076 N NMe Q1y a bond Me a bond NH O a bond Q3a OH
    3077 N NMe Q1z a bond Me a bond NH O a bond Q3a OH
    3078 CH NH Q1w a bond Me a bond NH S a bond Q3a OH
    3079 CH NH Q1w a bond Me a bond NH S a bond Q3b OH
    3080 CH NH Q1w a bond Me a bond NH S a bond Q3c OH
    3081 CH NH Q1w a bond Me a bond NH O NH Q3a OH
    3082 CH NH Q1w a bond Me a bond NH O NH Q3b OH
    3083 CH NH Q1w a bond Me a bond NH O NH Q3c OH
    3084 CH NH Q1w a bond Me a bond NH O a bond Q3a OH
    3085 CH NH Q1w a bond Me a bond NH O a bond Q3b OH
    3086 CH NH Q1w a bond Me a bond NH O a bond Q3c OH
    3087 CH NH Q1w a bond H a bond NH S NH Q3a OH
    3088 CH NH Q1w a bond H a bond NH S NH Q3b OH
    3089 CH NH Q1w a bond H a bond NH S NH Q3c OH
    3090 CH NH Q1w a bond H a bond NH S a bond Q3a OH
    3091 CH NH Q1w a bond H a bond NH S a bond Q3b OH
    3092 CH NH Q1w a bond H a bond NH S a bond Q3c OH
    3093 CH NH Q1w a bond H a bond NH O NH Q3a OH
    3094 CH NH Q1w a bond H a bond NH O NH Q3b OH
    3095 CH NH Q1w a bond H a bond NH O NH Q3c OH
    3096 CH NH Q1w a bond H a bond NH O a bond Q3a OH
    3097 CH NH Q1w a bond H a bond NH O a bond Q3b OH
    3098 CH NH Q1w a bond H a bond NH O a bond Q3c OH
    3099 CH NH Q1x a bond Me a bond NH S NH Q3a OH
    3100 CH NH Q1x a bond Me a bond NH S NH Q3b OH
    3101 CH NH Q1x a bond Me a bond NH S NH Q3c OH
    3102 CH NH Q1x a bond Me a bond NH S a bond Q3a OH
    3103 CH NH Q1x a bond Me a bond NH S a bond Q3b OH
    3104 CH NH Q1x a bond Me a bond NH S a bond Q3c OH
    3105 CH NH Q1x a bond Me a bond NH O NH Q3a OH
    3106 CH NH Q1x a bond Me a bond NH O NH Q3b OH
    3107 CH NH Q1x a bond Me a bond NH O NH Q3c OH
    3108 CH NH Q1x a bond Me a bond NH O a bond Q3a OH
    3109 CH NH Q1x a bond Me a bond NH O a bond Q3b OH
    3110 CH NH Q1x a bond Me a bond NH O a bond Q3c OH
    3111 CH NH Q1x a bond H a bond NH S NH Q3a OH
    3112 CH NH Q1x a bond H a bond NH S NH Q3b OH
    3113 CH NH Q1x a bond H a bond NH S NH Q3c OH
    3114 CH NH Q1x a bond H a bond NH S a bond Q3a OH
    3115 CH NH Q1x a bond H a bond NH S a bond Q3b OH
    3116 CH NH Q1x a bond H a bond NH S a bond Q3c OH
    3117 CH NH Q1x a bond H a bond NH O NH Q3a OH
    3118 CH NH Q1x a bond H a bond NH O NH Q3b OH
    3119 CH NH Q1x a bond H a bond NH O NH Q3c OH
    3120 CH NH Q1x a bond H a bond NH O a bond Q3a OH
    3121 CH NH Q1x a bond H a bond NH O a bond Q3b OH
    3122 CH NH Q1x a bond H a bond NH O a bond Q3c OH
    3123 CMe NH Q1o a bond Me a bond NH S NH Q3a OH
    3124 CMe NH Q1o a bond Me a bond NH S NH Q3b OH
    3125 CMe NH Q1o a bond Me a bond NH S NH Q3c OH
    3126 CMe NH Q1o a bond Me a bond NH S a bond Q3a OH
    3127 CMe NH Q1o a bond Me a bond NH S a bond Q3b OH
    3128 CMe NH Q1o a bond Me a bond NH S a bond Q3c OH
    3129 CMe NH Q1o a bond Me a bond NH O NH Q3a OH
    3130 CMe NH Q1o a bond Me a bond NH O NH Q3b OH
    3131 CMe NH Q1o a bond Me a bond NH O NH Q3c OH
    3132 CMe NH Q1o a bond Me a bond NH O a bond Q3a OH
    3133 CMe NH Q1o a bond Me a bond NH O a bond Q3b OH
    3134 CMe NH Q1o a bond Me a bond NH O a bond Q3c OH
    3135 CMe NH Q1o a bond H a bond NH S NH Q3a OH
    3136 CMe NH Q1o a bond H a bond NH S NH Q3b OH
    3137 CMe NH Q1o a bond H a bond NH S NH Q3c OH
    3138 CMe NH Q1o a bond H a bond NH S a bond Q3a OH
    3139 CMe NH Q1o a bond H a bond NH S a bond Q3b OH
    3140 CMe NH Q1o a bond H a bond NH S a bond Q3c OH
    3141 CMe NH Q1o a bond H a bond NH O NH Q3a OH
    3142 CMe NH Q1o a bond H a bond NH O NH Q3b OH
    3143 CMe NH Q1o a bond H a bond NH O NH Q3c OH
    3144 CMe NH Q1o a bond H a bond NH O a bond Q3a OH
    3145 CMe NH Q1o a bond H a bond NH O a bond Q3b OH
    3146 CMe NH Q1o a bond H a bond NH O a bond Q3c OH
    3147 CMe NH Q1p a bond Me a bond NH S NH Q3a OH
    3148 CMe NH Q1p a bond Me a bond NH S NH Q3b OH
    3149 CMe NH Q1p a bond Me a bond NH S NH Q3c OH
    3150 CMe NH Q1p a bond Me a bond NH S a bond Q3a OH
    3151 CMe NH Q1p a bond Me a bond NH S a bond Q3b OH
    3152 CMe NH Q1p a bond Me a bond NH S a bond Q3c OH
    3153 CMe NH Q1p a bond Me a bond NH O NH Q3a OH
    3154 CMe NH Q1p a bond Me a bond NH O NH Q3b OH
    3155 CMe NH Q1p a bond Me a bond NH O NH Q3c OH
    3156 CMe NH Q1p a bond Me a bond NH O a bond Q3a OH
    3157 CMe NH Q1p a bond Me a bond NH O a bond Q3b OH
    3158 CMe NH Q1p a bond Me a bond NH O a bond Q3c OH
    3159 CMe NH Q1p a bond H a bond NH S NH Q3a OH
    3160 CMe NH Q1p a bond H a bond NH S NH Q3b OH
    3161 CMe NH Q1p a bond H a bond NH S NH Q3c OH
    3162 CMe NH Q1p a bond H a bond NH S a bond Q3a OH
    3163 CMe NH Q1p a bond H a bond NH S a bond Q3b OH
    3164 CMe NH Q1p a bond H a bond NH S a bond Q3c OH
    3165 CMe NH Q1p a bond H a bond NH O NH Q3a OH
    3166 CMe NH Q1p a bond H a bond NH O NH Q3b OH
    3167 CMe NH Q1p a bond H a bond NH O NH Q3c OH
    3168 CMe NH Q1p a bond H a bond NH O a bond Q3a OH
    3169 CMe NH Q1p a bond H a bond NH O a bond Q3b OH
    3170 CMe NH Q1p a bond H a bond NH O a bond Q3c OH
    3171 CMe NH Q1q a bond Me a bond NH S NH Q3a OH
    3172 CMe NH Q1q a bond Me a bond NH S NH Q3b OH
    3173 CMe NH Q1q a bond Me a bond NH S NH Q3c OH
    3174 CMe NH Q1q a bond Me a bond NH S a bond Q3a OH
    3175 CMe NH Q1q a bond Me a bond NH S a bond Q3b OH
    3176 CMe NH Q1q a bond Me a bond NH S a bond Q3c OH
    3177 CMe NH Q1q a bond Me a bond NH O NH Q3a OH
    3178 CMe NH Q1q a bond Me a bond NH O NH Q3b OH
    3179 CMe NH Q1q a bond Me a bond NH O NH Q3c OH
    3180 CMe NH Q1q a bond Me a bond NH O a bond Q3a OH
    3181 CMe NH Q1q a bond Me a bond NH O a bond Q3b OH
    3182 CMe NH Q1q a bond Me a bond NH O a bond Q3c OH
    3183 CMe NH Q1q a bond H a bond NH S NH Q3a OH
    3184 CMe NH Q1q a bond H a bond NH S NH Q3b OH
    3185 CMe NH Q1q a bond H a bond NH S NH Q3c OH
    3186 CMe NH Q1q a bond H a bond NH S a bond Q3a OH
    3187 CMe NH Q1q a bond H a bond NH S a bond Q3b OH
    3188 CMe NH Q1q a bond H a bond NH S a bond Q3c OH
    3189 CMe NH Q1q a bond H a bond NH O NH Q3a OH
    3190 CMe NH Q1q a bond H a bond NH O NH Q3b OH
    3191 CMe NH Q1q a bond H a bond NH O NH Q3c OH
    3192 CMe NH Q1q a bond H a bond NH O a bond Q3a OH
    3193 CMe NH Q1q a bond H a bond NH O a bond Q3b OH
    3194 CMe NH Q1q a bond H a bond NH O a bond Q3c OH
    3195 CMe NH Q1r a bond Me a bond NH S NH Q3a OH
    3196 CMe NH Q1r a bond Me a bond NH S NH Q3b OH
    3197 CMe NH Q1r a bond Me a bond NH S NH Q3c OH
    3198 CMe NH Q1r a bond Me a bond NH S a bond Q3a OH
    3199 CMe NH Q1r a bond Me a bond NH S a bond Q3b OH
    3200 CMe NH Q1r a bond Me a bond NH S a bond Q3c OH
    3201 CMe NH Q1r a bond Me a bond NH O NH Q3a OH
    3202 CMe NH Q1r a bond Me a bond NH O NH Q3b OH
    3203 CMe NH Q1r a bond Me a bond NH O NH Q3c OH
    3204 CMe NH Q1r a bond Me a bond NH O a bond Q3a OH
    3205 CMe NH Q1r a bond Me a bond NH O a bond Q3b OH
    3206 CMe NH Q1r a bond Me a bond NH O a bond Q3c OH
    3207 CMe NH Q1r a bond H a bond NH S NH Q3a OH
    3208 CMe NH Q1r a bond H a bond NH S NH Q3b OH
    3209 CMe NH Q1r a bond H a bond NH S NH Q3c OH
    3210 CMe NH Q1r a bond H a bond NH S a bond Q3a OH
    3211 CMe NH Q1r a bond H a bond NH S a bond Q3b OH
    3212 CMe NH Q1r a bond H a bond NH S a bond Q3c OH
    3213 CMe NH Q1r a bond H a bond NH O NH Q3a OH
    3214 CMe NH Q1r a bond H a bond NH O NH Q3b OH
    3215 CMe NH Q1r a bond H a bond NH O NH Q3c OH
    3216 CMe NH Q1r a bond H a bond NH O a bond Q3a OH
    3217 CMe NH Q1r a bond H a bond NH O a bond Q3b OH
    3218 CMe NH Q1r a bond H a bond NH O a bond Q3c OH
    3219 CMe NH Q1s a bond Me a bond NH S NH Q3a OH
    3220 CMe NH Q1s a bond Me a bond NH S NH Q3b OH
    3221 CMe NH Q1s a bond Me a bond NH S NH Q3c OH
    3222 CMe NH Q1s a bond Me a bond NH S a bond Q3a OH
    3223 CMe NH Q1s a bond Me a bond NH S a bond Q3b OH
    3224 CMe NH Q1s a bond Me a bond NH S a bond Q3c OH
    3225 CMe NH Q1s a bond Me a bond NH O NH Q3a OH
    3226 CMe NH Q1s a bond Me a bond NH O NH Q3b OH
    3227 CMe NH Q1s a bond Me a bond NH O NH Q3c OH
    3228 CMe NH Q1s a bond Me a bond NH O a bond Q3a OH
    3229 CMe NH Q1s a bond Me a bond NH O a bond Q3b OH
    3230 CMe NH Q1s a bond Me a bond NH O a bond Q3c OH
    3231 CMe NH Q1s a bond H a bond NH S NH Q3a OH
    3232 CMe NH Q1s a bond H a bond NH S NH Q3b OH
    3233 CMe NH Q1s a bond H a bond NH S NH Q3c OH
    3234 CMe NH Q1s a bond H a bond NH S a bond Q3a OH
    3235 CMe NH Q1s a bond H a bond NH S a bond Q3b OH
    3236 CMe NH Q1s a bond H a bond NH S a bond Q3c OH
    3237 CMe NH Q1s a bond H a bond NH O NH Q3a OH
    3238 CMe NH Q1s a bond H a bond NH O NH Q3b OH
    3239 CMe NH Q1s a bond H a bond NH O NH Q3c OH
    3240 CMe NH Q1s a bond H a bond NH O a bond Q3a OH
    3241 CMe NH Q1s a bond H a bond NH O a bond Q3b OH
    3242 CMe NH Q1s a bond H a bond NH O a bond Q3c OH
    3243 CMe NH Q1t a bond Me a bond NH S NH Q3a OH
    3244 CMe NH Q1t a bond Me a bond NH S NH Q3b OH
    3245 CMe NH Q1t a bond Me a bond NH S NH Q3c OH
    3246 CMe NH Q1t a bond Me a bond NH S a bond Q3a OH
    3247 CMe NH Q1t a bond Me a bond NH S a bond Q3b OH
    3248 CMe NH Q1t a bond Me a bond NH S a bond Q3c OH
    3249 CMe NH Q1t a bond Me a bond NH O NH Q3a OH
    3250 CMe NH Q1t a bond Me a bond NH O NH Q3b OH
    3251 CMe NH Q1t a bond Me a bond NH O NH Q3c OH
    3252 CMe NH Q1t a bond Me a bond NH O a bond Q3a OH
    3253 CMe NH Q1t a bond Me a bond NH O a bond Q3b OH
    3254 CMe NH Q1t a bond Me a bond NH O a bond Q3c OH
    3255 CMe NH Q1t a bond H a bond NH S NH Q3a OH
    3256 CMe NH Q1t a bond H a bond NH S NH Q3b OH
    3257 CMe NH Q1t a bond H a bond NH S NH Q3c OH
    3258 CMe NH Q1t a bond H a bond NH S a bond Q3a OH
    3259 CMe NH Q1t a bond H a bond NH S a bond Q3b OH
    3260 CMe NH Q1t a bond H a bond NH S a bond Q3c OH
    3261 CMe NH Q1t a bond H a bond NH O NH Q3a OH
    3262 CMe NH Q1t a bond H a bond NH O NH Q3b OH
    3263 CMe NH Q1t a bond H a bond NH O NH Q3c OH
    3264 CMe NH Q1t a bond H a bond NH O a bond Q3a OH
    3265 CMe NH Q1t a bond H a bond NH O a bond Q3b OH
    3266 CMe NH Q1t a bond H a bond NH O a bond Q3c OH
    3267 CMe NH Q1u a bond Me a bond NH S NH Q3a OH
    3268 CMe NH Q1u a bond Me a bond NH S NH Q3b OH
    3269 CMe NH Q1u a bond Me a bond NH S NH Q3c OH
    3270 CMe NH Q1u a bond Me a bond NH S a bond Q3a OH
    3271 CMe NH Q1u a bond Me a bond NH S a bond Q3b OH
    3272 CMe NH Q1u a bond Me a bond NH S a bond Q3c OH
    3273 CMe NH Q1u a bond Me a bond NH O NH Q3a OH
    3274 CMe NH Q1u a bond Me a bond NH O NH Q3b OH
    3275 CMe NH Q1u a bond Me a bond NH O NH Q3c OH
    3276 CMe NH Q1u a bond Me a bond NH O a bond Q3a OH
    3277 CMe NH Q1u a bond Me a bond NH O a bond Q3b OH
    3278 CMe NH Q1u a bond Me a bond NH O a bond Q3c OH
    3279 CMe NH Q1u a bond H a bond NH S NH Q3a OH
    3280 CMe NH Q1u a bond H a bond NH S NH Q3b OH
    3281 CMe NH Q1u a bond H a bond NH S NH Q3c OH
    3282 CMe NH Q1u a bond H a bond NH S a bond Q3a OH
    3283 CMe NH Q1u a bond H a bond NH S a bond Q3b OH
    3284 CMe NH Q1u a bond H a bond NH S a bond Q3c OH
    3285 CMe NH Q1u a bond H a bond NH O NH Q3a OH
    3286 CMe NH Q1u a bond H a bond NH O NH Q3b OH
    3287 CMe NH Q1u a bond H a bond NH O NH Q3c OH
    3288 CMe NH Q1u a bond H a bond NH O a bond Q3a OH
    3289 CMe NH Q1u a bond H a bond NH O a bond Q3b OH
    3290 CMe NH Q1u a bond H a bond NH O a bond Q3c OH
    3291 CMe NH Q1v a bond Me a bond NH S NH Q3a OH
    3292 CMe NH Q1v a bond Me a bond NH S NH Q3b OH
    3293 CMe NH Q1v a bond Me a bond NH S NH Q3c OH
    3294 CMe NH Q1v a bond Me a bond NH S a bond Q3a OH
    3295 CMe NH Q1v a bond Me a bond NH S a bond Q3b OH
    3296 CMe NH Q1v a bond Me a bond NH S a bond Q3c OH
    3297 CMe NH Q1v a bond Me a bond NH O NH Q3a OH
    3298 CMe NH Q1v a bond Me a bond NH O NH Q3b OH
    3299 CMe NH Q1v a bond Me a bond NH O NH Q3c OH
    3300 CMe NH Q1v a bond Me a bond NH O a bond Q3a OH
    3301 CMe NH Q1v a bond Me a bond NH O a bond Q3b OH
    3302 CMe NH Q1v a bond Me a bond NH O a bond Q3c OH
    3303 CMe NH Q1v a bond H a bond NH S NH Q3a OH
    3304 CMe NH Q1v a bond H a bond NH S NH Q3b OH
    3305 CMe NH Q1v a bond H a bond NH S NH Q3c OH
    3306 CMe NH Q1v a bond H a bond NH S a bond Q3a OH
    3307 CMe NH Q1v a bond H a bond NH S a bond Q3b OH
    3308 CMe NH Q1v a bond H a bond NH S a bond Q3c OH
    3309 CMe NH Q1v a bond H a bond NH O NH Q3a OH
    3310 CMe NH Q1v a bond H a bond NH O NH Q3b OH
    3311 CMe NH Q1v a bond H a bond NH O NH Q3c OH
    3312 CMe NH Q1v a bond H a bond NH O a bond Q3a OH
    3313 CMe NH Q1v a bond H a bond NH O a bond Q3b OH
    3314 CMe NH Q1v a bond H a bond NH O a bond Q3c OH
    3315 CMe NH Q1w a bond Me a bond NH S NH Q3a OH
    3316 CMe NH Q1w a bond Me a bond NH S NH Q3b OH
    3317 CMe NH Q1w a bond Me a bond NH S NH Q3c OH
    3318 CMe NH Q1w a bond Me a bond NH S a bond Q3a OH
    3319 CMe NH Q1w a bond Me a bond NH S a bond Q3b OH
    3320 CMe NH Q1w a bond Me a bond NH S a bond Q3c OH
    3321 CMe NH Q1w a bond Me a bond NH O NH Q3a OH
    3322 CMe NH Q1w a bond Me a bond NH O NH Q3b OH
    3323 CMe NH Q1w a bond Me a bond NH O NH Q3c OH
    3324 CMe NH Q1w a bond Me a bond NH O a bond Q3a OH
    3325 CMe NH Q1w a bond Me a bond NH O a bond Q3b OH
    3326 CMe NH Q1w a bond Me a bond NH O a bond Q3c OH
    3327 CMe NH Q1w a bond H a bond NH S NH Q3a OH
    3328 CMe NH Q1w a bond H a bond NH S NH Q3b OH
    3329 CMe NH Q1w a bond H a bond NH S NH Q3c OH
    3330 CMe NH Q1w a bond H a bond NH S a bond Q3a OH
    3331 CMe NH Q1w a bond H a bond NH S a bond Q3b OH
    3332 CMe NH Q1w a bond H a bond NH S a bond Q3c OH
    3333 CMe NH Q1w a bond H a bond NH O NH Q3a OH
    3334 CMe NH Q1w a bond H a bond NH O NH Q3b OH
    3335 CMe NH Q1w a bond H a bond NH O NH Q3c OH
    3336 CMe NH Q1w a bond H a bond NH O a bond Q3a OH
    3337 CMe NH Q1w a bond H a bond NH O a bond Q3b OH
    3338 CMe NH Q1w a bond H a bond NH O a bond Q3c OH
    3339 CMe NH Q1x a bond Me a bond NH S NH Q3a OH
    3340 CMe NH Q1x a bond Me a bond NH S NH Q3b OH
    3341 CMe NH Q1x a bond Me a bond NH S NH Q3c OH
    3342 CMe NH Q1x a bond Me a bond NH S a bond Q3a OH
    3343 CMe NH Q1x a bond Me a bond NH S a bond Q3b OH
    3344 CMe NH Q1x a bond Me a bond NH S a bond Q3c OH
    3345 CMe NH Q1x a bond Me a bond NH O NH Q3a OH
    3346 CMe NH Q1x a bond Me a bond NH O NH Q3b OH
    3347 CMe NH Q1x a bond Me a bond NH O NH Q3c OH
    3348 CMe NH Q1x a bond Me a bond NH O a bond Q3a OH
    3349 CMe NH Q1x a bond Me a bond NH O a bond Q3b OH
    3350 CMe NH Q1x a bond Me a bond NH O a bond Q3c OH
    3351 CMe NH Q1x a bond H a bond NH S NH Q3a OH
    3352 CMe NH Q1x a bond H a bond NH S NH Q3b OH
    3353 CMe NH Q1x a bond H a bond NH S NH Q3c OH
    3354 CMe NH Q1x a bond H a bond NH S a bond Q3a OH
    3355 CMe NH Q1x a bond H a bond NH S a bond Q3b OH
    3356 CMe NH Q1x a bond H a bond NH S a bond Q3c OH
    3357 CMe NH Q1x a bond H a bond NH O NH Q3a OH
    3358 CMe NH Q1x a bond H a bond NH O NH Q3b OH
    3359 CMe NH Q1x a bond H a bond NH O NH Q3c OH
    3360 CMe NH Q1x a bond H a bond NH O a bond Q3a OH
    3361 CMe NH Q1x a bond H a bond NH O a bond Q3b OH
    3362 CMe NH Q1x a bond H a bond NH O a bond Q3c OH
  • 70) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 3, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 3 denote the flowing substituents.
  • Figure US20140051857A1-20140220-C00007
  • TABLE 3
    No A B R1 L1 R2 L2 L3 Y L4 R3 X
    1 N NMe Q1a NH Me a bond NH S NH Q3a OH
    2 N NMe Q1a NH Me a bond NH S a bond Q3a OH
    3 N NMe Q1a NH Me a bond NH O NH Q3a OH
    4 N NMe Q1a NH Me a bond NH O a bond Q3a OH
    5 N NMe Q1a NH H a bond NH S NH Q3a OH
    6 N NMe Q1a NH H a bond NH S a bond Q3a OH
    7 N NMe Q1a NH H a bond NH O NH Q3a OH
    8 N NMe Q1a NH H a bond NH O a bond Q3a OH
    9 N NMe Q1b NH Me a bond NH S NH Q3a OH
    10 N NMe Q1b NH Me a bond NH S a bond Q3a OH
    11 N NMe Q1b NH Me a bond NH O NH Q3a OH
    12 N NMe Q1b NH Me a bond NH O a bond Q3a OH
    13 N NMe Q1b NH H a bond NH S NH Q3a OH
    14 N NMe Q1b NH H a bond NH S a bond Q3a OH
    15 N NMe Q1b NH H a bond NH O NH Q3a OH
    16 N NMe Q1b NH H a bond NH O a bond Q3a OH
    17 N S Q1a NH Me a bond NH S NH Q3a OH
    18 N S Q1a NH Me a bond NH S a bond Q3a OH
    19 N S Q1a NH Me a bond NH O NH Q3a OH
    20 N S Q1a NH Me a bond NH O a bond Q3a OH
    21 N S Q1a NH H a bond NH S NH Q3a OH
    22 N S Q1a NH H a bond NH S a bond Q3a OH
    23 N S Q1a NH H a bond NH O NH Q3a OH
    24 N S Q1a NH H a bond NH O a bond Q3a OH
    25 N S Q1b NH Me a bond NH S NH Q3a OH
    26 N S Q1b NH Me a bond NH S a bond Q3a OH
    27 N S Q1b NH Me a bond NH O NH Q3a OH
    28 N S Q1b NH Me a bond NH O a bond Q3a OH
    29 N S Q1b NH H a bond NH S NH Q3a OH
    30 N S Q1b NH H a bond NH S a bond Q3a OH
    31 N S Q1b NH H a bond NH O NH Q3a OH
    32 N S Q1b NH H a bond NH O a bond Q3a OH
    33 N O Q1a NH Me a bond NH S NH Q3a OH
    34 N O Q1a NH Me a bond NH S a bond Q3a OH
    35 N O Q1a NH Me a bond NH O NH Q3a OH
    36 N O Q1a NH Me a bond NH O a bond Q3a OH
    37 N O Q1a NH H a bond NH S NH Q3a OH
    38 N O Q1a NH H a bond NH S a bond Q3a OH
    39 N O Q1a NH H a bond NH O NH Q3a OH
    40 N O Q1a NH H a bond NH O a bond Q3a OH
    41 N O Q1b NH Me a bond NH S NH Q3a OH
    42 N O Q1b NH Me a bond NH S a bond Q3a OH
    43 N O Q1b NH Me a bond NH O NH Q3a OH
    44 N O Q1b NH Me a bond NH O a bond Q3a OH
    45 N O Q1b NH H a bond NH S NH Q3a OH
    46 N O Q1b NH H a bond NH S a bond Q3a OH
    47 N O Q1b NH H a bond NH O NH Q3a OH
    48 N O Q1b NH H a bond NH O a bond Q3a OH
    49 CH NMe Q1a NH Me a bond NH S NH Q3a OH
    50 CH NMe Q1a NH Me a bond NH S a bond Q3a OH
    51 CH NMe Q1a NH Me a bond NH O NH Q3a OH
    52 CH NMe Q1a NH Me a bond NH O a bond Q3a OH
    53 CH NMe Q1a NH H a bond NH S NH Q3a OH
    54 CH NMe Q1a NH H a bond NH S a bond Q3a OH
    55 CH NMe Q1a NH H a bond NH O NH Q3a OH
    56 CH NMe Q1a NH H a bond NH O a bond Q3a OH
    57 CH NMe Q1b NH Me a bond NH S NH Q3a OH
    58 CH NMe Q1b NH Me a bond NH S a bond Q3a OH
    59 CH NMe Q1b NH Me a bond NH O NH Q3a OH
    60 CH NMe Q1b NH Me a bond NH O a bond Q3a OH
    61 CH NMe Q1b NH H a bond NH S NH Q3a OH
    62 CH NMe Q1b NH H a bond NH S a bond Q3a OH
    63 CH NMe Q1b NH H a bond NH O NH Q3a OH
    64 CH NMe Q1b NH H a bond NH O a bond Q3a OH
    65 CH S Q1a NH Me a bond NH S NH Q3a OH
    66 CH S Q1a NH Me a bond NH S a bond Q3a OH
    67 CH S Q1a NH Me a bond NH O NH Q3a OH
    68 CH S Q1a NH Me a bond NH O a bond Q3a OH
    69 CH S Q1a NH H a bond NH S NH Q3a OH
    70 CH S Q1a NH H a bond NH S a bond Q3a OH
    71 CH S Q1a NH H a bond NH O NH Q3a OH
    72 CH S Q1a NH H a bond NH O a bond Q3a OH
    73 CH S Q1b NH Me a bond NH S NH Q3a OH
    74 CH S Q1b NH Me a bond NH S a bond Q3a OH
    75 CH S Q1b NH Me a bond NH O NH Q3a OH
    76 CH S Q1b NH Me a bond NH O a bond Q3a OH
    77 CH S Q1b NH H a bond NH S NH Q3a OH
    78 CH S Q1b NH H a bond NH S a bond Q3a OH
    79 CH S Q1b NH H a bond NH O NH Q3a OH
    80 CH S Q1b NH H a bond NH O a bond Q3a OH
    81 CH O Q1a NH Me a bond NH S NH Q3a OH
    82 CH O Q1a NH Me a bond NH S a bond Q3a OH
    83 CH O Q1a NH Me a bond NH O NH Q3a OH
    84 CH O Q1a NH Me a bond NH O a bond Q3a OH
    85 CH O Q1a NH H a bond NH S NH Q3a OH
    86 CH O Q1a NH H a bond NH S a bond Q3a OH
    87 CH O Q1a NH H a bond NH O NH Q3a OH
    88 CH O Q1a NH H a bond NH O a bond Q3a OH
    89 CH O Q1b NH Me a bond NH S NH Q3a OH
    90 CH O Q1b NH Me a bond NH S a bond Q3a OH
    91 CH O Q1b NH Me a bond NH O NH Q3a OH
    92 CH O Q1b NH Me a bond NH O a bond Q3a OH
    93 CH O Q1b NH H a bond NH S NH Q3a OH
    94 CH O Q1b NH H a bond NH S a bond Q3a OH
    95 CH O Q1b NH H a bond NH O NH Q3a OH
    96 CH O Q1b NH H a bond NH O a bond Q3a OH
    97 CMe NMe Q1a NH Me a bond NH S NH Q3a OH
    98 CMe NMe Q1a NH Me a bond NH S a bond Q3a OH
    99 CMe NMe Q1a NH Me a bond NH O NH Q3a OH
    100 CMe NMe Q1a NH Me a bond NH O a bond Q3a OH
    101 CMe NMe Q1a NH H a bond NH S NH Q3a OH
    102 CMe NMe Q1a NH H a bond NH S a bond Q3a OH
    103 CMe NMe Q1a NH H a bond NH O NH Q3a OH
    104 CMe NMe Q1a NH H a bond NH O a bond Q3a OH
    105 CMe NMe Q1b NH Me a bond NH S NH Q3a OH
    106 CMe NMe Q1b NH Me a bond NH S a bond Q3a OH
    107 CMe NMe Q1b NH Me a bond NH O NH Q3a OH
    108 CMe NMe Q1b NH Me a bond NH O a bond Q3a OH
    109 CMe NMe Q1b NH H a bond NH S NH Q3a OH
    110 CMe NMe Q1b NH H a bond NH S a bond Q3a OH
    111 CMe NMe Q1b NH H a bond NH O NH Q3a OH
    112 CMe NMe Q1b NH H a bond NH O a bond Q3a OH
    113 CMe S Q1a NH Me a bond NH S NH Q3a OH
    114 CMe S Q1a NH Me a bond NH S a bond Q3a OH
    115 CMe S Q1a NH Me a bond NH O NH Q3a OH
    116 CMe S Q1a NH Me a bond NH O a bond Q3a OH
    117 CMe S Q1a NH H a bond NH S NH Q3a OH
    118 CMe S Q1a NH H a bond NH S a bond Q3a OH
    119 CMe S Q1a NH H a bond NH O NH Q3a OH
    120 CMe S Q1a NH H a bond NH O a bond Q3a OH
    121 CMe S Q1b NH Me a bond NH S NH Q3a OH
    122 CMe S Q1b NH Me a bond NH S a bond Q3a OH
    123 CMe S Q1b NH Me a bond NH O NH Q3a OH
    124 CMe S Q1b NH Me a bond NH O a bond Q3a OH
    125 CMe S Q1b NH H a bond NH S NH Q3a OH
    126 CMe S Q1b NH H a bond NH S a bond Q3a OH
    127 CMe S Q1b NH H a bond NH O NH Q3a OH
    128 CMe S Q1b NH H a bond NH O a bond Q3a OH
    129 CMe O Q1a NH Me a bond NH S NH Q3a OH
    130 CMe O Q1a NH Me a bond NH S a bond Q3a OH
    131 CMe O Q1a NH Me a bond NH O NH Q3a OH
    132 CMe O Q1a NH Me a bond NH O a bond Q3a OH
    133 CMe O Q1a NH H a bond NH S NH Q3a OH
    134 CMe O Q1a NH H a bond NH S a bond Q3a OH
    135 CMe O Q1a NH H a bond NH O NH Q3a OH
    136 CMe O Q1a NH H a bond NH O a bond Q3a OH
    137 CMe O Q1b NH Me a bond NH S NH Q3a OH
    138 CMe O Q1b NH Me a bond NH S a bond Q3a OH
    139 CMe O Q1b NH Me a bond NH O NH Q3a OH
    140 CMe O Q1b NH Me a bond NH O a bond Q3a OH
    141 CMe O Q1b NH H a bond NH S NH Q3a OH
    142 CMe O Q1b NH H a bond NH S a bond Q3a OH
    143 CMe O Q1b NH H a bond NH O NH Q3a OH
    144 CMe O Q1b NH H a bond NH O a bond Q3a OH
    145 N NMe Q1a O Me a bond NH S NH Q3a OH
    146 N NMe Q1a O Me a bond NH S a bond Q3a OH
    147 N NMe Q1a O Me a bond NH O NH Q3a OH
    148 N NMe Q1a O Me a bond NH O a bond Q3a OH
    149 N NMe Q1a O H a bond NH S NH Q3a OH
    150 N NMe Q1a O H a bond NH S a bond Q3a OH
    151 N NMe Q1a O H a bond NH O NH Q3a OH
    152 N NMe Q1a O H a bond NH O a bond Q3a OH
    153 N NMe Q1b O Me a bond NH S NH Q3a OH
    154 N NMe Q1b O Me a bond NH S a bond Q3a OH
    155 N NMe Q1b O Me a bond NH O NH Q3a OH
    156 N NMe Q1b O Me a bond NH O a bond Q3a OH
    157 N NMe Q1b O H a bond NH S NH Q3a OH
    158 N NMe Q1b O H a bond NH S a bond Q3a OH
    159 N NMe Q1b O H a bond NH O NH Q3a OH
    160 N NMe Q1b O H a bond NH O a bond Q3a OH
    161 N S Q1a O Me a bond NH S NH Q3a OH
    162 N S Q1a O Me a bond NH S a bond Q3a OH
    163 N S Q1a O Me a bond NH O NH Q3a OH
    164 N S Q1a O Me a bond NH O a bond Q3a OH
    165 N S Q1a O H a bond NH S NH Q3a OH
    166 N S Q1a O H a bond NH S a bond Q3a OH
    167 N S Q1a O H a bond NH O NH Q3a OH
    168 N S Q1a O H a bond NH O a bond Q3a OH
    169 N S Q1b O Me a bond NH S NH Q3a OH
    170 N S Q1b O Me a bond NH S a bond Q3a OH
    171 N S Q1b O Me a bond NH O NH Q3a OH
    172 N S Q1b O Me a bond NH O a bond Q3a OH
    173 N S Q1b O H a bond NH S NH Q3a OH
    174 N S Q1b O H a bond NH S a bond Q3a OH
    175 N S Q1b O H a bond NH O NH Q3a OH
    176 N S Q1b O H a bond NH O a bond Q3a OH
    177 N O Q1a O Me a bond NH S NH Q3a OH
    178 N O Q1a O Me a bond NH S a bond Q3a OH
    179 N O Q1a O Me a bond NH O NH Q3a OH
    180 N O Q1a O Me a bond NH O a bond Q3a OH
    181 N O Q1a O H a bond NH S NH Q3a OH
    182 N O Q1a O H a bond NH S a bond Q3a OH
    183 N O Q1a O H a bond NH O NH Q3a OH
    184 N O Q1a O H a bond NH O a bond Q3a OH
    185 N O Q1b O Me a bond NH S NH Q3a OH
    186 N O Q1b O Me a bond NH S a bond Q3a OH
    187 N O Q1b O Me a bond NH O NH Q3a OH
    188 N O Q1b O Me a bond NH O a bond Q3a OH
    189 N O Q1b O H a bond NH S NH Q3a OH
    190 N O Q1b O H a bond NH S a bond Q3a OH
    191 N O Q1b O H a bond NH O NH Q3a OH
    192 N O Q1b O H a bond NH O a bond Q3a OH
    193 CH NMe Q1a O Me a bond NH S NH Q3a OH
    194 CH NMe Q1a O Me a bond NH S a bond Q3a OH
    195 CH NMe Q1a O Me a bond NH O NH Q3a OH
    196 CH NMe Q1a O Me a bond NH O a bond Q3a OH
    197 CH NMe Q1a O H a bond NH S NH Q3a OH
    198 CH NMe Q1a O H a bond NH S a bond Q3a OH
    199 CH NMe Q1a O H a bond NH O NH Q3a OH
    200 CH NMe Q1a O H a bond NH O a bond Q3a OH
    201 CH NMe Q1b O Me a bond NH S NH Q3a OH
    202 CH NMe Q1b O Me a bond NH S a bond Q3a OH
    203 CH NMe Q1b O Me a bond NH O NH Q3a OH
    204 CH NMe Q1b O Me a bond NH O a bond Q3a OH
    205 CH NMe Q1b O H a bond NH S NH Q3a OH
    206 CH NMe Q1b O H a bond NH S a bond Q3a OH
    207 CH NMe Q1b O H a bond NH O NH Q3a OH
    208 CH NMe Q1b O H a bond NH O a bond Q3a OH
    209 CH S Q1a O Me a bond NH S NH Q3a OH
    210 CH S Q1a O Me a bond NH S a bond Q3a OH
    211 CH S Q1a O Me a bond NH O NH Q3a OH
    212 CH S Q1a O Me a bond NH O a bond Q3a OH
    213 CH S Q1a O H a bond NH S NH Q3a OH
    214 CH S Q1a O H a bond NH S a bond Q3a OH
    215 CH S Q1a O H a bond NH O NH Q3a OH
    216 CH S Q1a O H a bond NH O a bond Q3a OH
    217 CH S Q1b O Me a bond NH S NH Q3a OH
    218 CH S Q1b O Me a bond NH S a bond Q3a OH
    219 CH S Q1b O Me a bond NH O NH Q3a OH
    220 CH S Q1b O Me a bond NH O a bond Q3a OH
    221 CH S Q1b O H a bond NH S NH Q3a OH
    222 CH S Q1b O H a bond NH S a bond Q3a OH
    223 CH S Q1b O H a bond NH O NH Q3a OH
    224 CH S Q1b O H a bond NH O a bond Q3a OH
    225 CH O Q1a O Me a bond NH S NH Q3a OH
    226 CH O Q1a O Me a bond NH S a bond Q3a OH
    227 CH O Q1a O Me a bond NH O NH Q3a OH
    228 CH O Q1a O Me a bond NH O a bond Q3a OH
    229 CH O Q1a O H a bond NH S NH Q3a OH
    230 CH O Q1a O H a bond NH S a bond Q3a OH
    231 CH O Q1a O H a bond NH O NH Q3a OH
    232 CH O Q1a O H a bond NH O a bond Q3a OH
    233 CH O Q1b O Me a bond NH S NH Q3a OH
    234 CH O Q1b O Me a bond NH S a bond Q3a OH
    235 CH O Q1b O Me a bond NH O NH Q3a OH
    236 CH O Q1b O Me a bond NH O a bond Q3a OH
    237 CH O Q1b O H a bond NH S NH Q3a OH
    238 CH O Q1b O H a bond NH S a bond Q3a OH
    239 CH O Q1b O H a bond NH O NH Q3a OH
    240 CH O Q1b O H a bond NH O a bond Q3a OH
    241 CMe NMe Q1a O Me a bond NH S NH Q3a OH
    242 CMe NMe Q1a O Me a bond NH S a bond Q3a OH
    243 CMe NMe Q1a O Me a bond NH O NH Q3a OH
    244 CMe NMe Q1a O Me a bond NH O a bond Q3a OH
    245 CMe NMe Q1a O H a bond NH S NH Q3a OH
    246 CMe NMe Q1a O H a bond NH S a bond Q3a OH
    247 CMe NMe Q1a O H a bond NH O NH Q3a OH
    248 CMe NMe Q1a O H a bond NH O a bond Q3a OH
    249 CMe NMe Q1b O Me a bond NH S NH Q3a OH
    250 CMe NMe Q1b O Me a bond NH S a bond Q3a OH
    251 CMe NMe Q1b O Me a bond NH O NH Q3a OH
    252 CMe NMe Q1b O Me a bond NH O a bond Q3a OH
    253 CMe NMe Q1b O H a bond NH S NH Q3a OH
    254 CMe NMe Q1b O H a bond NH S a bond Q3a OH
    255 CMe NMe Q1b O H a bond NH O NH Q3a OH
    256 CMe NMe Q1b O H a bond NH O a bond Q3a OH
    257 CMe S Q1a O Me a bond NH S NH Q3a OH
    258 CMe S Q1a O Me a bond NH S a bond Q3a OH
    259 CMe S Q1a O Me a bond NH O NH Q3a OH
    260 CMe S Q1a O Me a bond NH O a bond Q3a OH
    261 CMe S Q1a O H a bond NH S NH Q3a OH
    262 CMe S Q1a O H a bond NH S a bond Q3a OH
    263 CMe S Q1a O H a bond NH O NH Q3a OH
    264 CMe S Q1a O H a bond NH O a bond Q3a OH
    265 CMe S Q1b O Me a bond NH S NH Q3a OH
    266 CMe S Q1b O Me a bond NH S a bond Q3a OH
    267 CMe S Q1b O Me a bond NH O NH Q3a OH
    268 CMe S Q1b O Me a bond NH O a bond Q3a OH
    269 CMe S Q1b O H a bond NH S NH Q3a OH
    270 CMe S Q1b O H a bond NH S a bond Q3a OH
    271 CMe S Q1b O H a bond NH O NH Q3a OH
    272 CMe S Q1b O H a bond NH O a bond Q3a OH
    273 CMe O Q1a O Me a bond NH S NH Q3a OH
    274 CMe O Q1a O Me a bond NH S a bond Q3a OH
    275 CMe O Q1a O Me a bond NH O NH Q3a OH
    276 CMe O Q1a O Me a bond NH O a bond Q3a OH
    277 CMe O Q1a O H a bond NH S NH Q3a OH
    278 CMe O Q1a O H a bond NH S a bond Q3a OH
    279 CMe O Q1a O H a bond NH O NH Q3a OH
    280 CMe O Q1a O H a bond NH O a bond Q3a OH
    281 CMe O Q1b O Me a bond NH S NH Q3a OH
    282 CMe O Q1b O Me a bond NH S a bond Q3a OH
    283 CMe O Q1b O Me a bond NH O NH Q3a OH
    284 CMe O Q1b O Me a bond NH O a bond Q3a OH
    285 CMe O Q1b O H a bond NH S NH Q3a OH
    286 CMe O Q1b O H a bond NH S a bond Q3a OH
    287 CMe O Q1b O H a bond NH O NH Q3a OH
    288 CMe O Q1b O H a bond NH O a bond Q3a OH
    289 N NMe Q1a CH2 Me a bond NH S NH Q3a OH
    290 N NMe Q1a CH2 Me a bond NH S a bond Q3a OH
    291 N NMe Q1a CH2 Me a bond NH O NH Q3a OH
    292 N NMe Q1a CH2 Me a bond NH O a bond Q3a OH
    293 N NMe Q1a CH2 H a bond NH S NH Q3a OH
    294 N NMe Q1a CH2 H a bond NH S a bond Q3a OH
    295 N NMe Q1a CH2 H a bond NH O NH Q3a OH
    296 N NMe Q1a CH2 H a bond NH O a bond Q3a OH
    297 N NMe Q1b CH2 Me a bond NH S NH Q3a OH
    298 N NMe Q1b CH2 Me a bond NH S a bond Q3a OH
    299 N NMe Q1b CH2 Me a bond NH O NH Q3a OH
    300 N NMe Q1b CH2 Me a bond NH O a bond Q3a OH
    301 N NMe Q1b CH2 H a bond NH S NH Q3a OH
    302 N NMe Q1b CH2 H a bond NH S a bond Q3a OH
    303 N NMe Q1b CH2 H a bond NH O NH Q3a OH
    304 N NMe Q1b CH2 H a bond NH O a bond Q3a OH
    305 N S Q1a CH2 Me a bond NH S NH Q3a OH
    306 N S Q1a CH2 Me a bond NH S a bond Q3a OH
    307 N S Q1a CH2 Me a bond NH O NH Q3a OH
    308 N S Q1a CH2 Me a bond NH O a bond Q3a OH
    309 N S Q1a CH2 H a bond NH S NH Q3a OH
    310 N S Q1a CH2 H a bond NH S a bond Q3a OH
    311 N S Q1a CH2 H a bond NH O NH Q3a OH
    312 N S Q1a CH2 H a bond NH O a bond Q3a OH
    313 N S Q1b CH2 Me a bond NH S NH Q3a OH
    314 N S Q1b CH2 Me a bond NH S a bond Q3a OH
    315 N S Q1b CH2 Me a bond NH O NH Q3a OH
    316 N S Q1b CH2 Me a bond NH O a bond Q3a OH
    317 N S Q1b CH2 H a bond NH S NH Q3a OH
    318 N S Q1b CH2 H a bond NH S a bond Q3a OH
    319 N S Q1b CH2 H a bond NH O NH Q3a OH
    320 N S Q1b CH2 H a bond NH O a bond Q3a OH
    321 N O Q1a CH2 Me a bond NH S NH Q3a OH
    322 N O Q1a CH2 Me a bond NH S a bond Q3a OH
    323 N O Q1a CH2 Me a bond NH O NH Q3a OH
    324 N O Q1a CH2 Me a bond NH O a bond Q3a OH
    325 N O Q1a CH2 H a bond NH S NH Q3a OH
    326 N O Q1a CH2 H a bond NH S a bond Q3a OH
    327 N O Q1a CH2 H a bond NH O NH Q3a OH
    328 N O Q1a CH2 H a bond NH O a bond Q3a OH
    329 N O Q1b CH2 Me a bond NH S NH Q3a OH
    330 N O Q1b CH2 Me a bond NH S a bond Q3a OH
    331 N O Q1b CH2 Me a bond NH O NH Q3a OH
    332 N O Q1b CH2 Me a bond NH O a bond Q3a OH
    333 N O Q1b CH2 H a bond NH S NH Q3a OH
    334 N O Q1b CH2 H a bond NH S a bond Q3a OH
    335 N O Q1b CH2 H a bond NH O NH Q3a OH
    336 N O Q1b CH2 H a bond NH O a bond Q3a OH
    337 CH NMe Q1a CH2 Me a bond NH S NH Q3a OH
    338 CH NMe Q1a CH2 Me a bond NH S a bond Q3a OH
    339 CH NMe Q1a CH2 Me a bond NH O NH Q3 OH
    340 CH NMe Q1a CH2 Me a bond NH O a bond Q3a OH
    341 CH NMe Q1a CH2 H a bond NH S NH Q3a OH
    342 CH NMe Q1a CH2 H a bond NH S a bond Q3a OH
    343 CH NMe Q1a CH2 H a bond NH O NH Q3a OH
    344 CH NMe Q1a CH2 H a bond NH O a bond 3a OH
    345 CH NMe Q1b CH2 Me a bond NH S NH Q3a OH
    346 CH NMe Q1b CH2 Me a bond NH S a bond Q3a OH
    347 CH NMe Q1b CH2 Me a bond NH O NH Q3a OH
    348 CH NMe Q1b CH2 Me a bond NH O a bond Q3a OH
    349 CH NMe Q1b CH2 H a bond NH S NH Q3a OH
    350 CH NMe Q1b CH2 H a bond NH S a bond Q3a OH
    351 CH NMe Q1b CH2 H a bond NH O NH Q3a OH
    352 CH NMe Q1b CH2 H a bond NH O a bond Q3a OH
    353 CH S Q1a CH2 Me a bond NH S NH Q3a OH
    354 CH S Q1a CH2 Me a bond NH S a bond Q3a OH
    355 CH S Q1a CH2 Me a bond NH O NH Q3a OH
    356 CH S Q1a CH2 Me a bond NH O a bond Q3a OH
    357 CH S Q1a CH2 H a bond NH S NH Q3a OH
    358 CH S Q1a CH2 H a bond NH S a bond Q3a OH
    359 CH S Q1a CH2 H a bond NH O NH Q3a OH
    360 CH S Q1a CH2 H a bond NH O a bond Q3a OH
    361 CH S Q1b CH2 Me a bond NH S NH Q3a OH
    362 CH S Q1b CH2 Me a bond NH S a bond Q3a OH
    363 CH S Q1b CH2 Me a bond NH O NH Q3a OH
    364 CH S Q1b CH2 Me a bond NH O a bond Q3a OH
    365 CH S Q1b CH2 H a bond NH S NH Q3a OH
    366 CH S Q1b CH2 H a bond NH S a bond Q3a OH
    367 CH S Q1b CH2 H a bond NH O NH Q3a OH
    368 CH S Q1b CH2 H a bond NH O a bond Q3a OH
    369 CH O Q1a CH2 Me a bond NH S NH Q3a OH
    370 CH O Q1a CH2 Me a bond NH S a bond Q3a OH
    371 CH O Q1a CH2 Me a bond NH O NH Q3a OH
    372 CH O Q1a CH2 Me a bond NH O a bond Q3a OH
    373 CH O Q1a CH2 H a bond NH S NH Q3a OH
    374 CH O Q1a CH2 H a bond NH S a bond Q3a OH
    375 CH O Q1a CH2 H a bond NH O NH Q3a OH
    376 CH O Q1a CH2 H a bond NH O a bond Q3a OH
    377 CH O Q1b CH2 Me a bond NH S NH Q3a OH
    378 CH O Q1b CH2 Me a bond NH S a bond Q3a OH
    379 CH O Q1b CH2 Me a bond NH O NH Q3a OH
    380 CH O Q1b CH2 Me a bond NH O a bond Q3a OH
    381 CH O Q1b CH2 H a bond NH S NH Q3a OH
    382 CH O Q1b CH2 H a bond NH S a bond Q3a OH
    383 CH O Q1b CH2 H a bond NH O NH Q3a OH
    384 CH O Q1b CH2 H a bond NH O a bond Q3a OH
    385 CMe NMe Q1a CH2 Me a bond NH S NH Q3a OH
    386 CMe NMe Q1a CH2 Me a bond NH S a bond Q3a OH
    387 CMe NMe Q1a CH2 Me a bond NH O NH Q3a OH
    388 CMe NMe Q1a CH2 Me a bond NH O a bond Q3a OH
    389 CMe NMe Q1a CH2 H a bond NH S NH Q3a OH
    390 CMe NMe Q1a CH2 H a bond NH S a bond Q3a OH
    391 CMe NMe Q1a CH2 H a bond NH O NH Q3a OH
    392 CMe NMe Q1a CH2 H a bond NH O a bond Q3a OH
    393 CMe NMe Q1b CH2 Me a bond NH S NH Q3a OH
    394 CMe NMe Q1b CH2 Me a bond NH S a bond Q3a OH
    395 CMe NMe Q1b CH2 Me a bond NH O NH Q3a OH
    396 CMe NMe Q1b CH2 Me a bond NH O a bond Q3a OH
    397 CMe NMe Q1b CH2 H a bond NH S NH Q3a OH
    398 CMe NMe Q1b CH2 H a bond NH S a bond Q3a OH
    399 CMe NMe Q1b CH2 H a bond NH O NH Q3a OH
    400 CMe NMe Q1b CH2 H a bond NH O a bond Q3a OH
    401 CMe S Q1a CH2 Me a bond NH S NH Q3a OH
    402 CMe S Q1a CH2 Me a bond NH S a bond Q3a OH
    403 CMe S Q1a CH2 Me a bond NH O NH Q3a OH
    404 CMe S Q1a CH2 Me a bond NH O a bond Q3a OH
    405 CMe S Q1a CH2 H a bond NH S NH Q3a OH
    406 CMe S Q1a CH2 H a bond NH S a bond Q3a OH
    407 CMe S Q1a CH2 H a bond NH O NH Q3a OH
    408 CMe S Q1a CH2 H a bond NH O a bond Q3a OH
    409 CMe S Q1b CH2 Me a bond NH S NH Q3a OH
    410 CMe S Q1b CH2 Me a bond NH S a bond Q3a OH
    411 CMe S Q1b CH2 Me a bond NH O NH Q3a OH
    412 CMe S Q1b CH2 Me a bond NH O a bond Q3a OH
    413 CMe S Q1b CH2 H a bond NH S NH Q3a OH
    414 CMe S Q1b CH2 H a bond NH S a bond Q3a OH
    415 CMe S Q1b CH2 H a bond NH O NH Q3a OH
    416 CMe S Q1b CH2 H a bond NH O a bond Q3a OH
    417 CMe O Q1a CH2 Me a bond NH S NH Q3a OH
    418 CMe O Q1a CH2 Me a bond NH S a bond Q3a OH
    419 CMe O Q1a CH2 Me a bond NH O NH Q3a OH
    420 CMe O Q1a CH2 Me a bond NH O a bond Q3a OH
    421 CMe O Q1a CH2 H a bond NH S NH Q3a OH
    422 CMe O Q1a CH2 H a bond NH S a bond Q3a OH
    423 CMe O Q1a CH2 H a bond NH O NH Q3a OH
    424 CMe O Q1a CH2 H a bond NH O a bond Q3a OH
    425 CMe O Q1b CH2 Me a bond NH S NH Q3a OH
    426 CMe O Q1b CH2 Me a bond NH S a bond Q3a OH
    427 CMe O Q1b CH2 Me a bond NH O NH Q3a OH
    428 CMe O Q1b CH2 Me a bond NH O a bond Q3a OH
    429 CMe O Q1b CH2 H a bond NH S NH Q3a OH
    430 CMe O Q1b CH2 H a bond NH S a bond Q3a OH
    431 CMe O Q1b CH2 H a bond NH O NH Q3a OH
    432 CMe O Q1b CH2 H a bond NH O a bond Q3a OH
    433 N NMe Q1a a bond Me a bond NH S CH2 Q3a OH
    434 N NMe Q1a a bond Me a bond NH O CH2 Q3a OH
    435 N NMe Q1a a bond H a bond NH S CH2 Q3a OH
    436 N NMe Q1a a bond H a bond NH O CH2 Q3a OH
    437 N NMe Q1b a bond Me a bond NH S CH2 Q3a OH
    438 N NMe Q1b a bond Me a bond NH O CH2 Q3a OH
    439 N NMe Q1b a bond H a bond NH S CH2 Q3a OH
    440 N NMe Q1b a bond H a bond NH O CH2 Q3a OH
    441 N S Q1a a bond Me a bond NH S CH2 Q3a OH
    442 N S Q1a a bond Me a bond NH O CH2 Q3a OH
    443 N S Q1a a bond H a bond NH S CH2 Q3a OH
    444 N S Q1a a bond H a bond NH O CH2 Q3a OH
    445 N S Q1b a bond Me a bond NH S CH2 Q3a OH
    446 N S Q1b a bond Me a bond NH O CH2 Q3a OH
    447 N S Q1b a bond H a bond NH S CH2 Q3a OH
    448 N S Q1b a bond H a bond NH O CH2 Q3a OH
    449 N O Q1a a bond Me a bond NH S CH2 Q3a OH
    450 N O Q1a a bond Me a bond NH O CH2 Q3a OH
    451 N O Q1a a bond H a bond NH S CH2 Q3a OH
    452 N O Q1a a bond H a bond NH O CH2 Q3a OH
    453 N O Q1b a bond Me a bond NH S CH2 Q3a OH
    454 N O Q1b a bond Me a bond NH O CH2 Q3a OH
    455 N O Q1b a bond H a bond NH S CH2 Q3a OH
    456 N O Q1b a bond H a bond NH O CH2 Q3a OH
    457 CH NMe Q1a a bond Me a bond NH S CH2 Q3a OH
    458 CH NMe Q1a a bond Me a bond NH O CH2 Q3a OH
    459 CH NMe Q1a a bond H a bond NH S CH2 Q3a OH
    460 CH NMe Q1a a bond H a bond NH O CH2 Q3a OH
    461 CH NMe Q1b a bond Me a bond NH S CH2 Q3a OH
    462 CH NMe Q1b a bond Me a bond NH O CH2 Q3a OH
    463 CH NMe Q1b a bond H a bond NH S CH2 Q3a OH
    464 CH NMe Q1b a bond H a bond NH O CH2 Q3a OH
    465 CH S Q1a a bond Me a bond NH S CH2 Q3a OH
    466 CH S Q1a a bond Me a bond NH O CH2 Q3a OH
    467 CH S Q1a a bond H a bond NH S CH2 Q3a OH
    468 CH S Q1a a bond H a bond NH O CH2 Q3a OH
    469 CH S Q1b a bond Me a bond NH S CH2 Q3a OH
    470 CH S Q1b a bond Me a bond NH O CH2 Q3a OH
    471 CH S Q1b a bond H a bond NH S CH2 Q3a OH
    472 CH S Q1b a bond H a bond NH O CH2 Q3a OH
    473 CH O Q1a a bond Me a bond NH S CH2 Q3a OH
    474 CH O Q1a a bond Me a bond NH O CH2 Q3a OH
    475 CH O Q1a a bond H a bond NH S CH2 Q3a OH
    476 CH O Q1a a bond H a bond NH O CH2 Q3a OH
    477 CH O Q1b a bond Me a bond NH S CH2 Q3a OH
    478 CH O Q1b a bond Me a bond NH O CH2 Q3a OH
    479 CH O Q1b a bond H a bond NH S CH2 Q3a OH
    480 CH O Q1b a bond H a bond NH O CH2 Q3a OH
    481 CMe NMe Q1a a bond Me a bond NH S CH2 Q3a OH
    482 CMe NMe Q1a a bond Me a bond NH O CH2 Q3a OH
    483 CMe NMe Q1a a bond H a bond NH S CH2 Q3a OH
    484 CMe NMe Q1a a bond H a bond NH O CH2 Q3a OH
    485 CMe NMe Q1b a bond Me a bond NH S CH2 Q3a OH
    486 CMe NMe Q1b a bond Me a bond NH O CH2 Q3a OH
    487 CMe NMe Q1b a bond H a bond NH S CH2 Q3a OH
    488 CMe NMe Q1b a bond H a bond NH O CH2 Q3a OH
    489 CMe S Q1a a bond Me a bond NH S CH2 Q3a OH
    490 CMe S Q1a a bond Me a bond NH O CH2 Q3a OH
    491 CMe S Q1a a bond H a bond NH S CH2 Q3a OH
    492 CMe S Q1a a bond H a bond NH O CH2 Q3a OH
    493 CMe S Q1b a bond Me a bond NH S CH2 Q3a OH
    494 CMe S Q1b a bond Me a bond NH O CH2 Q3a OH
    495 CMe S Q1b a bond H a bond NH S CH2 Q3a OH
    496 CMe S Q1b a bond H a bond NH O CH2 Q3a OH
    497 CMe O Q1a a bond Me a bond NH S CH2 Q3a OH
    498 CMe O Q1a a bond Me a bond NH O CH2 Q3a OH
    499 CMe O Q1a a bond H a bond NH S CH2 Q3a OH
    500 CMe O Q1a a bond H a bond NH O CH2 Q3a OH
    501 CMe O Q1b a bond Me a bond NH S CH2 Q3a OH
    502 CMe O Q1b a bond Me a bond NH O CH2 Q3a OH
    503 CMe O Q1b a bond H a bond NH S CH2 Q3a OH
    504 CMe O Q1b a bond H a bond NH O CH2 Q3a OH
    505 N NMe Q1a a bond Me a bond CH2 S a bond Q3a OH
    506 N NMe Q1a a bond Me a bond CH2 S NH Q3a OH
    507 N NMe Q1a a bond Me a bond CH2 O a bond Q3a OH
    508 N NMe Q1a a bond Me a bond CH2 O NH Q3a OH
    509 N NMe Q1a a bond H a bond CH2 S a bond Q3a OH
    510 N NMe Q1a a bond H a bond CH2 S NH Q3a OH
    511 N NMe Q1a a bond H a bond CH2 O a bond Q3a OH
    512 N NMe Q1a a bond H a bond CH2 O NH Q3a OH
    513 N NMe Q1b a bond Me a bond CH2 S a bond Q3a OH
    514 N NMe Q1b a bond Me a bond CH2 S NH Q3a OH
    515 N NMe Q1b a bond Me a bond CH2 O a bond Q3a OH
    516 N NMe Q1b a bond Me a bond CH2 O NH Q3a OH
    517 N NMe Q1b a bond H a bond CH2 S a bond Q3a OH
    518 N NMe Q1b a bond H a bond CH2 S NH Q3a OH
    519 N NMe Q1b a bond H a bond CH2 O a bond Q3a OH
    520 N NMe Q1b a bond H a bond CH2 O NH Q3a OH
    521 N S Q1a a bond Me a bond CH2 S a bond Q3a OH
    522 N S Q1a a bond Me a bond CH2 S NH Q3a OH
    523 N S Q1a a bond Me a bond CH2 O a bond Q3a OH
    524 N S Q1a a bond Me a bond CH2 O NH Q3a OH
    525 N S Q1a a bond H a bond CH2 S a bond Q3a OH
    526 N S Q1a a bond H a bond CH2 S NH Q3a OH
    527 N S Q1a a bond H a bond CH2 O a bond Q3a OH
    528 N S Q1a a bond H a bond CH2 O NH Q3a OH
    529 N S Q1b a bond Me a bond CH2 S a bond Q3a OH
    530 N S Q1b a bond Me a bond CH2 S NH Q3a OH
    531 N S Q1b a bond Me a bond CH2 O a bond Q3a OH
    532 N S Q1b a bond Me a bond CH2 O NH Q3a OH
    533 N S Q1b a bond H a bond CH2 S a bond Q3a OH
    534 N S Q1b a bond H a bond CH2 S NH Q3a OH
    535 N S Q1b a bond H a bond CH2 O a bond Q3a OH
    536 N S Q1b a bond H a bond CH2 O NH Q3a OH
    537 N O Q1a a bond Me a bond CH2 S a bond Q3a OH
    538 N O Q1a a bond Me a bond CH2 S NH Q3a OH
    539 N O Q1a a bond Me a bond CH2 O a bond Q3a OH
    540 N O Q1a a bond Me a bond CH2 O NH Q3a OH
    541 N O Q1a a bond H a bond CH2 S a bond Q3a OH
    542 N O Q1a a bond H a bond CH2 S NH Q3a OH
    543 N O Q1a a bond H a bond CH2 O a bond Q3a OH
    544 N O Q1a a bond H a bond CH2 O NH Q3a OH
    545 N O Q1b a bond Me a bond CH2 S a bond Q3a OH
    546 N O Q1b a bond Me a bond CH2 S NH Q3a OH
    547 N O Q1b a bond Me a bond CH2 O a bond Q3a OH
    548 N O Q1b a bond Me a bond CH2 O NH Q3a OH
    549 N O Q1b a bond H a bond CH2 S a bond Q3a OH
    550 N O Q1b a bond H a bond CH2 S NH Q3a OH
    551 N O Q1b a bond H a bond CH2 O a bond Q3a OH
    552 N O Q1b a bond H a bond CH2 O NH Q3a OH
    553 CH NMe Q1a a bond Me a bond CH2 S a bond Q3a OH
    554 CH NMe Q1a a bond Me a bond CH2 S NH Q3a OH
    555 CH NMe Q1a a bond Me a bond CH2 O a bond Q3a OH
    556 CH NMe Q1a a bond Me a bond CH2 O NH Q3a OH
    557 CH NMe Q1a a bond H a bond CH2 S a bond Q3a OH
    558 CH NMe Q1a a bond H a bond CH2 S NH Q3a OH
    559 CH NMe Q1a a bond H a bond CH2 O a bond Q3a OH
    560 CH NMe Q1a a bond H a bond CH2 O NH Q3a OH
    561 CH NMe Q1b a bond Me a bond CH2 S a bond Q3a OH
    562 CH NMe Q1b a bond Me a bond CH2 S NH Q3a OH
    563 CH NMe Q1b a bond Me a bond CH2 O a bond Q3a OH
    564 CH NMe Q1b a bond Me a bond CH2 O NH Q3a OH
    565 CH NMe Q1b a bond H a bond CH2 S a bond Q3a OH
    566 CH NMe Q1b a bond H a bond CH2 S NH Q3a OH
    567 CH NMe Q1b a bond H a bond CH2 O a bond Q3a OH
    568 CH NMe Q1b a bond H a bond CH2 O NH Q3a OH
    569 CH S Q1a a bond Me a bond CH2 S a bond Q3a OH
    570 CH S Q1a a bond Me a bond CH2 S NH Q3a OH
    571 CH S Q1a a bond Me a bond CH2 O a bond Q3a OH
    572 CH S Q1a a bond Me a bond CH2 O NH Q3a OH
    573 CH S Q1a a bond H a bond CH2 S a bond Q3a OH
    574 CH S Q1a a bond H a bond CH2 S NH Q3a OH
    575 CH S Q1a a bond H a bond CH2 O a bond Q3a OH
    576 CH S Q1a a bond H a bond CH2 O NH Q3a OH
    577 CH S Q1b a bond Me a bond CH2 S a bond Q3a OH
    578 CH S Q1b a bond Me a bond CH2 S NH Q3a OH
    579 CH S Q1b a bond Me a bond CH2 O a bond Q3a OH
    580 CH S Q1b a bond Me a bond CH2 O NH Q3a OH
    581 CH S Q1b a bond H a bond CH2 S a bond Q3a OH
    582 CH S Q1b a bond H a bond CH2 S NH Q3a OH
    583 CH S Q1b a bond H a bond CH2 O a bond Q3a OH
    584 CH S Q1b a bond H a bond CH2 O NH Q3a OH
    585 CH O Q1a a bond Me a bond CH2 S a bond Q3a OH
    586 CH O Q1a a bond Me a bond CH2 S NH Q3a OH
    587 CH O Q1a a bond Me a bond CH2 O a bond Q3a OH
    588 CH O Q1a a bond Me a bond CH2 O NH Q3a OH
    589 CH O Q1a a bond H a bond CH2 S a bond Q3a OH
    590 CH O Q1a a bond H a bond CH2 S NH Q3a OH
    591 CH O Q1a a bond H a bond CH2 O a bond Q3a OH
    592 CH O Q1a a bond H a bond CH2 O NH Q3a OH
    593 CH O Q1b a bond Me a bond CH2 S a bond Q3a OH
    594 CH O Q1b a bond Me a bond CH2 S NH Q3a OH
    595 CH O Q1b a bond Me a bond CH2 O a bond Q3a OH
    596 CH O Q1b a bond Me a bond CH2 O NH Q3a OH
    597 CH O Q1b a bond H a bond CH2 S a bond Q3a OH
    598 CH O Q1b a bond H a bond CH2 S NH Q3a OH
    599 CH O Q1b a bond H a bond CH2 O a bond Q3a OH
    600 CH O Q1b a bond H a bond CH2 O NH Q3a OH
    601 CMe NMe Q1a a bond Me a bond CH2 S a bond Q3a OH
    602 CMe NMe Q1a a bond Me a bond CH2 S NH Q3a OH
    603 CMe NMe Q1a a bond Me a bond CH2 O a bond Q3a OH
    604 CMe NMe Q1a a bond Me a bond CH2 O NH Q3a OH
    605 CMe NMe Q1a a bond H a bond CH2 S a bond Q3a OH
    606 CMe NMe Q1a a bond H a bond CH2 S NH Q3a OH
    607 CMe NMe Q1a a bond H a bond CH2 O a bond Q3a OH
    608 CMe NMe Q1a a bond H a bond CH2 O NH Q3a OH
    609 CMe NMe Q1b a bond Me a bond CH2 S a bond Q3a OH
    610 CMe NMe Q1b a bond Me a bond CH2 S NH Q3a OH
    611 CMe NMe Q1b a bond Me a bond CH2 O a bond Q3a OH
    612 CMe NMe Q1b a bond Me a bond CH2 O NH Q3a OH
    613 CMe NMe Q1b a bond H a bond CH2 S a bond Q3a OH
    614 CMe NMe Q1b a bond H a bond CH2 S NH Q3a OH
    615 CMe NMe Q1b a bond H a bond CH2 O a bond Q3a OH
    616 CMe NMe Q1b a bond H a bond CH2 O NH Q3a OH
    617 CMe S Q1a a bond Me a bond CH2 S a bond Q3a OH
    618 CMe S Q1a a bond Me a bond CH2 S NH Q3a OH
    619 CMe S Q1a a bond Me a bond CH2 O a bond Q3a OH
    620 CMe S Q1a a bond Me a bond CH2 O NH Q3a OH
    621 CMe S Q1a a bond H a bond CH2 S a bond Q3a OH
    622 CMe S Q1a a bond H a bond CH2 S NH Q3a OH
    623 CMe S Q1a a bond H a bond CH2 O a bond Q3a OH
    624 CMe S Q1a a bond H a bond CH2 O NH Q3a OH
    625 CMe S Q1b a bond Me a bond CH2 S a bond Q3a OH
    626 CMe S Q1b a bond Me a bond CH2 S NH Q3a OH
    627 CMe S Q1b a bond Me a bond CH2 O a bond Q3a OH
    628 CMe S Q1b a bond Me a bond CH2 O NH Q3a OH
    629 CMe S Q1b a bond H a bond CH2 S a bond Q3a OH
    630 CMe S Q1b a bond H a bond CH2 S NH Q3a OH
    631 CMe S Q1b a bond H a bond CH2 O a bond Q3a OH
    632 CMe S Q1b a bond H a bond CH2 O NH Q3a OH
    633 CMe O Q1a a bond Me a bond CH2 S a bond Q3a OH
    634 CMe O Q1a a bond Me a bond CH2 S NH Q3a OH
    635 CMe O Q1a a bond Me a bond CH2 O a bond Q3a OH
    636 CMe O Q1a a bond Me a bond CH2 O NH Q3a OH
    637 CMe O Q1a a bond H a bond CH2 S a bond Q3a OH
    638 CMe O Q1a a bond H a bond CH2 S NH Q3a OH
    639 CMe O Q1a a bond H a bond CH2 O a bond Q3a OH
    640 CMe O Q1a a bond H a bond CH2 O NH Q3a OH
    641 CMe O Q1b a bond Me a bond CH2 S a bond Q3a OH
    642 CMe O Q1b a bond Me a bond CH2 S NH Q3a OH
    643 CMe O Q1b a bond Me a bond CH2 O a bond Q3a OH
    644 CMe O Q1b a bond Me a bond CH2 O NH Q3a OH
    645 CMe O Q1b a bond H a bond CH2 S a bond Q3a OH
    646 CMe O Q1b a bond H a bond CH2 S NH Q3a OH
    647 CMe O Q1b a bond H a bond CH2 O a bond Q3a OH
    648 CMe O Q1b a bond H a bond CH2 O NH Q3a OH
    649 CMe NH Q1a NH Me a bond NH S NH Q3a OH
    650 CMe NH Q1a NH Me a bond NH S a bond Q3a OH
    651 CMe NH Q1a NH Me a bond NH O NH Q3a OH
    652 CMe NH Q1a NH Me a bond NH O a bond Q3a OH
    653 CMe NH Q1a NH H a bond NH S NH Q3a OH
    654 CMe NH Q1a NH H a bond NH S a bond Q3a OH
    655 CMe NH Q1a NH H a bond NH O NH Q3a OH
    656 CMe NH Q1a NH H a bond NH O a bond Q3a OH
    657 CMe NH Q1b NH Me a bond NH S NH Q3a OH
    658 CMe NH Q1b NH Me a bond NH S a bond Q3a OH
    659 CMe NH Q1b NH Me a bond NH O NH Q3a OH
    660 CMe NH Q1b NH Me a bond NH O a bond Q3a OH
    661 CMe NH Q1b NH H a bond NH S NH Q3a OH
    662 CMe NH Q1b NH H a bond NH S a bond Q3a OH
    663 CMe NH Q1b NH H a bond NH O NH Q3a OH
    664 CMe NH Q1b NH H a bond NH O a bond Q3a OH
    665 CMe NH Q1a O Me a bond NH S NH Q3a OH
    666 CMe NH Q1a O Me a bond NH S a bond Q3a OH
    667 CMe NH Q1a O Me a bond NH O NH Q3a OH
    668 CMe NH Q1a O Me a bond NH O a bond Q3a OH
    669 CMe NH Q1a O H a bond NH S NH Q3a OH
    670 CMe NH Q1a O H a bond NH S a bond Q3a OH
    671 CMe NH Q1a O H a bond NH O NH Q3a OH
    672 CMe NH Q1a O H a bond NH O a bond Q3a OH
    673 CMe NH Q1b O Me a bond NH S NH Q3a OH
    674 CMe NH Q1b O Me a bond NH S a bond Q3a OH
    675 CMe NH Q1b O Me a bond NH O NH Q3a OH
    676 CMe NH Q1b O Me a bond NH O a bond Q3a OH
    677 CMe NH Q1b O H a bond NH S NH Q3a OH
    678 CMe NH Q1b O H a bond NH S a bond Q3a OH
    679 CMe NH Q1b O H a bond NH O NH Q3a OH
    680 CMe NH Q1b O H a bond NH O a bond Q3a OH
    681 CMe NH Q1a CH2 Me a bond NH S NH Q3a OH
    682 CMe NH Q1a CH2 Me a bond NH S a bond Q3a OH
    683 CMe NH Q1a CH2 Me a bond NH O NH Q3a OH
    684 CMe NH Q1a CH2 Me a bond NH O a bond Q3a OH
    685 CMe NH Q1a CH2 H a bond NH S NH Q3a OH
    686 CMe NH Q1a CH2 H a bond NH S a bond Q3a OH
    687 CMe NH Q1a CH2 H a bond NH O NH Q3a OH
    688 CMe NH Q1a CH2 H a bond NH O a bond Q3a OH
    689 CMe NH Q1b CH2 Me a bond NH S NH Q3a OH
    690 CMe NH Q1b CH2 Me a bond NH S a bond Q3a OH
    691 CMe NH Q1b CH2 Me a bond NH O NH Q3a OH
    692 CMe NH Q1b CH2 Me a bond NH O a bond Q3a OH
    693 CMe NH Q1b CH2 H a bond NH S NH Q3a OH
    694 CMe NH Q1b CH2 H a bond NH S a bond Q3a OH
    695 CMe NH Q1b CH2 H a bond NH O NH Q3a OH
    696 CMe NH Q1b CH2 H a bond NH O a bond Q3a OH
    697 CMe NH Q1a a bond Me a bond NH S CH2 Q3a OH
    698 CMe NH Q1a a bond Me a bond NH O CH2 Q3a OH
    699 CMe NH Q1a a bond H a bond NH S CH2 Q3a OH
    700 CMe NH Q1a a bond H a bond NH O CH2 Q3a OH
    701 CMe NH Q1b a bond Me a bond NH S CH2 Q3a OH
    702 CMe NH Q1b a bond Me a bond NH O CH2 Q3a OH
    703 CMe NH Q1b a bond H a bond NH S CH2 Q3a OH
    704 CMe NH Q1b a bond H a bond NH O CH2 Q3a OH
    705 CMe NH Q1a a bond Me a bond CH2 S a bond Q3a OH
    706 CMe NH Q1a a bond Me a bond CH2 S NH Q3a OH
    707 CMe NH Q1a a bond Me a bond CH2 O a bond Q3a OH
    708 CMe NH Q1a a bond Me a bond CH2 O NH Q3a OH
    709 CMe NH Q1a a bond H a bond CH2 S a bond Q3a OH
    710 CMe NH Q1a a bond H a bond CH2 S NH Q3a OH
    711 CMe NH Q1a a bond H a bond CH2 O a bond Q3a OH
    712 CMe NH Q1a a bond H a bond CH2 O NH Q3a OH
    713 CMe NH Q1b a bond Me a bond CH2 S a bond Q3a OH
    714 CMe NH Q1b a bond Me a bond CH2 S NH Q3a OH
    715 CMe NH Q1b a bond Me a bond CH2 O a bond Q3a OH
    716 CMe NH Q1b a bond Me a bond CH2 O NH Q3a OH
    717 CMe NH Q1b a bond H a bond CH2 S a bond Q3a OH
    718 CMe NH Q1b a bond H a bond CH2 S NH Q3a OH
    719 CMe NH Q1b a bond H a bond CH2 O a bond Q3a OH
    720 CMe NH Q1b a bond H a bond CH2 O NH Q3a OH
  • 71) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 4, tautomers; prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 4 denote the flowing substituents.
  • Figure US20140051857A1-20140220-C00008
  • TABLE 4
    No A B R1 L1 R2 L2 L3 Y L4 R3 X
    1 N NMe Q1a a bond Me a bond NH S NH Q3i OH
    2 N NMe Q1a a bond Me a bond NH S NH Q3j OH
    3 N NMe Q1b a bond Me a bond NH S NH Q3i OH
    4 N NMe Q1b a bond Me a bond NH S NH Q3j OH
    5 N NMe Q1c a bond Me a bond NH S NH Q3i OH
    6 N NMe Q1c a bond Me a bond NH S NH Q3j OH
    7 N NEt Q1a a bond Me a bond NH S NH Q3i OH
    8 N NEt Q1a a bond Me a bond NH S NH Q3j OH
    9 N NEt Q1b a bond Me a bond NH S NH Q3i OH
    10 N NEt Q1b a bond Me a bond NH S NH Q3j OH
    11 N NEt Q1c a bond Me a bond NH S NH Q3i OH
    12 N NEt Q1c a bond Me a bond NH S NH Q3j OH
    13 N S Q1a a bond Me a bond NH S NH Q3i OH
    14 N S Q1a a bond Me a bond NH S NH Q3j OH
    15 N S Q1b a bond Me a bond NH S NH Q3i OH
    16 N S Q1b a bond Me a bond NH S NH Q3j OH
    17 N S Q1c a bond Me a bond NH S NH Q3i OH
    18 N S Q1c a bond Me a bond NH S NH Q3j OH
    19 N O Q1a a bond Me a bond NH S NH Q3i OH
    20 N O Q1a a bond Me a bond NH S NH Q3j OH
    21 N O Q1b a bond Me a bond NH S NH Q3i OH
    22 N O Q1b a bond Me a bond NH S NH Q3j OH
    23 N O Q1c a bond Me a bond NH S NH Q3i OH
    24 N O Q1c a bond Me a bond NH S NH Q3j OH
    25 CH NMe Q1a a bond Me a bond NH S NH Q3i OH
    26 CH NMe Q1a a bond Me a bond NH S NH Q3j OH
    27 CH NMe Q1b a bond Me a bond NH S NH Q3i OH
    28 CH NMe Q1b a bond Me a bond NH S NH Q3j OH
    29 CH NMe Q1c a bond Me a bond NH S NH Q3i OH
    30 CH NMe Q1c a bond Me a bond NH S NH Q3j OH
    31 CH NEt Q1a a bond Me a bond NH S NH Q3i OH
    32 CH NEt Q1a a bond Me a bond NH S NH Q3j OH
    33 CH NEt Q1b a bond Me a bond NH S NH Q3i OH
    34 CH NEt Q1b a bond Me a bond NH S NH Q3j OH
    35 CH NEt Q1c a bond Me a bond NH S NH Q3i OH
    36 CH NEt Q1c a bond Me a bond NH S NH Q3j OH
    37 CH S Q1a a bond Me a bond NH S NH Q3i OH
    38 CH S Q1a a bond Me a bond NH S NH Q3j OH
    39 CH S Q1b a bond Me a bond NH S NH Q3i OH
    40 CH S Q1b a bond Me a bond NH S NH Q3j OH
    41 CH S Q1c a bond Me a bond NH S NH Q3i OH
    42 CH S Q1c a bond Me a bond NH S NH Q3j OH
    43 CH O Q1a a bond Me a bond NH S NH Q3i OH
    44 CH O Q1a a bond Me a bond NH S NH Q3j OH
    45 CH O Q1b a bond Me a bond NH S NH Q3i OH
    46 CH O Q1b a bond Me a bond NH S NH Q3j OH
    47 CH O Q1c a bond Me a bond NH S NH Q3i OH
    48 CH O Q1c a bond Me a bond NH S NH Q3j OH
    49 CMe NMe Q1a a bond Me a bond NH S NH Q3i OH
    50 CMe NMe Q1a a bond Me a bond NH S NH Q3j OH
    51 CMe NMe Q1b a bond Me a bond NH S NH Q3i OH
    52 CMe NMe Q1b a bond Me a bond NH S NH Q3j OH
    53 CMe NMe Q1c a bond Me a bond NH S NH Q3i OH
    54 CMe NMe Q1c a bond Me a bond NH S NH Q3j OH
    55 CMe NEt Q1a a bond Me a bond NH S NH Q3i OH
    56 CMe NEt Q1a a bond Me a bond NH S NH Q3j OH
    57 CMe NEt Q1b a bond Me a bond NH S NH Q3i OH
    58 CMe NEt Q1b a bond Me a bond NH S NH Q3j OH
    59 CMe NEt Q1c a bond Me a bond NH S NH Q3i OH
    60 CMe NEt Q1c a bond Me a bond NH S NH Q3j OH
    61 CMe S Q1a a bond Me a bond NH S NH Q3i OH
    62 CMe S Q1a a bond Me a bond NH S NH Q3j OH
    63 CMe S Q1b a bond Me a bond NH S NH Q3i OH
    64 CMe S Q1b a bond Me a bond NH S NH Q3j OH
    65 CMe S Q1c a bond Me a bond NH S NH Q3i OH
    66 CMe S Q1c a bond Me a bond NH S NH Q3j OH
    67 CMe O Q1a a bond Me a bond NH S NH Q3i OH
    68 CMe O Q1a a bond Me a bond NH S NH Q3j OH
    69 CMe O Q1b a bond Me a bond NH S NH Q3i OH
    70 CMe O Q1b a bond Me a bond NH S NH Q3j OH
    71 CMe O Q1c a bond Me a bond NH S NH Q3i OH
    72 CMe O Q1c a bond Me a bond NH S NH Q3j OH
    73 N NMe Q1a a bond Me a bond NH O a bond Q3i OH
    74 N NMe Q1a a bond Me a bond NH O a bond Q3j OH
    75 N NMe Q1b a bond Me a bond NH O a bond Q3i OH
    76 N NMe Q1b a bond Me a bond NH O a bond Q3j OH
    77 N NMe Q1c a bond Me a bond NH O a bond Q3i OH
    78 N NMe Q1c a bond Me a bond NH O a bond Q3j OH
    79 N NEt Q1a a bond Me a bond NH O a bond Q3i OH
    80 N NEt Q1a a bond Me a bond NH O a bond Q3j OH
    81 N NEt Q1b a bond Me a bond NH O a bond Q3i OH
    82 N NEt Q1b a bond Me a bond NH O a bond Q3j OH
    83 N NEt Q1c a bond Me a bond NH O a bond Q3i OH
    84 N NEt Q1c a bond Me a bond NH O a bond Q3j OH
    85 N S Q1a a bond Me a bond NH O a bond Q3i OH
    86 N S Q1a a bond Me a bond NH O a bond Q3j OH
    87 N S Q1b a bond Me a bond NH O a bond Q3i OH
    88 N S Q1b a bond Me a bond NH O a bond Q3j OH
    89 N S Q1c a bond Me a bond NH O a bond Q3i OH
    90 N S Q1c a bond Me a bond NH O a bond Q3j OH
    91 N O Q1a a bond Me a bond NH O a bond Q3i OH
    92 N O Q1a a bond Me a bond NH O a bond Q3j OH
    93 N O Q1b a bond Me a bond NH O a bond Q3i OH
    94 N O Q1b a bond Me a bond NH O a bond Q3j OH
    95 N O Q1c a bond Me a bond NH O a bond Q3i OH
    96 N O Q1c a bond Me a bond NH O a bond Q3j OH
    97 CH NMe Q1a a bond Me a bond NH O a bond Q3i OH
    98 CH NMe Q1a a bond Me a bond NH O a bond Q3j OH
    99 CH NMe Q1b a bond Me a bond NH O a bond Q3i OH
    100 CH NMe Q1b a bond Me a bond NH O a bond Q3j OH
    101 CH NMe Q1c a bond Me a bond NH O a bond Q3i OH
    102 CH NMe Q1c a bond Me a bond NH O a bond Q3j OH
    103 CH NEt Q1a a bond Me a bond NH O a bond Q3i OH
    104 CH NEt Q1a a bond Me a bond NH O a bond Q3j OH
    105 CH NEt Q1b a bond Me a bond NH O a bond Q3i OH
    106 CH NEt Q1b a bond Me a bond NH O a bond Q3j OH
    107 CH NEt Q1c a bond Me a bond NH O a bond Q3i OH
    108 CH NEt Q1c a bond Me a bond NH O a bond Q3j OH
    109 CH S Q1a a bond Me a bond NH O a bond Q3i OH
    110 CH S Q1a a bond Me a bond NH O a bond Q3j OH
    111 CH S Q1b a bond Me a bond NH O a bond Q3i OH
    112 CH S Q1b a bond Me a bond NH O a bond Q3j OH
    113 CH S Q1c a bond Me a bond NH O a bond Q3i OH
    114 CH S Q1c a bond Me a bond NH O a bond Q3j OH
    115 CH O Q1a a bond Me a bond NH O a bond Q3i OH
    116 CH O Q1a a bond Me a bond NH O a bond Q3j OH
    117 CH O Q1b a bond Me a bond NH O a bond Q3i OH
    118 CH O Q1b a bond Me a bond NH O a bond Q3j OH
    119 CH O Q1c a bond Me a bond NH O a bond Q3i OH
    120 CH O Q1c a bond Me a bond NH O a bond Q3j OH
    121 CMe NMe Q1a a bond Me a bond NH O a bond Q3i OH
    122 CMe NMe Q1a a bond Me a bond NH O a bond Q3j OH
    123 CMe NMe Q1b a bond Me a bond NH O a bond Q3i OH
    124 CMe NMe Q1b a bond Me a bond NH O a bond Q3j OH
    125 CMe NMe Q1c a bond Me a bond NH O a bond Q3i OH
    126 CMe NMe Q1c a bond Me a bond NH O a bond Q3j OH
    127 CMe NEt Q1a a bond Me a bond NH O a bond Q3i OH
    128 CMe NEt Q1a a bond Me a bond NH O a bond Q3j OH
    129 CMe NEt Q1b a bond Me a bond NH O a bond Q3i OH
    130 CMe NEt Q1b a bond Me a bond NH O a bond Q3j OH
    131 CMe NEt Q1c a bond Me a bond NH O a bond Q3i OH
    132 CMe NEt Q1c a bond Me a bond NH O a bond Q3j OH
    133 CMe S Q1a a bond Me a bond NH O a bond Q3i OH
    134 CMe S Q1a a bond Me a bond NH O a bond Q3j OH
    135 CMe S Q1b a bond Me a bond NH O a bond Q3i OH
    136 CMe S Q1b a bond Me a bond NH O a bond Q3j OH
    137 CMe S Q1c a bond Me a bond NH O a bond Q3i OH
    138 CMe S Q1c a bond Me a bond NH O a bond Q3j OH
    139 CMe O Q1a a bond Me a bond NH O a bond Q3i OH
    140 CMe O Q1a a bond Me a bond NH O a bond Q3j OH
    141 CMe O Q1b a bond Me a bond NH O a bond Q3i OH
    142 CMe O Q1b a bond Me a bond NH O a bond Q3j OH
    143 CMe O Q1c a bond Me a bond NH O a bond Q3i OH
    144 CMe O Q1c a bond Me a bond NH O a bond Q3j OH
    145 CMe NH Q1a a bond Me a bond NH S NH Q3i OH
    146 CMe NH Q1a a bond Me a bond NH S NH Q3j OH
    147 CMe NH Q1b a bond Me a bond NH S NH Q3i OH
    148 CMe NH Q1b a bond Me a bond NH S NH Q3j OH
    149 CMe NH Q1c a bond Me a bond NH S NH Q3i OH
    150 CMe NH Q1c a bond Me a bond NH S NH Q3j OH
    151 CH NH Q1a a bond Me a bond NH O a bond Q3i OH
    152 CH NH Q1a a bond Me a bond NH O a bond Q3j OH
    153 CH NH Q1b a bond Me a bond NH O a bond Q3i OH
    154 CH NH Q1b a bond Me a bond NH O a bond Q3j OH
    155 CH NH Q1c a bond Me a bond NH O a bond Q3i OH
    156 CH NH Q1c a bond Me a bond NH O a bond Q3j OH
  • 72) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 5, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 5 denote the flowing substituents.
  • Figure US20140051857A1-20140220-C00009
    Figure US20140051857A1-20140220-C00010
  • TABLE 5
    No A B R1 L1 R2 L2 L3 Y L4 R3 X
    1 CMe NH Q1k a bond Me a bond NH O a bond Q3a OH
    2 CMe NH Q1k a bond Me a bond NH O a bond Q3d OH
    3 CMe NH Q1k a bond Me a bond NH O a bond Q3e OH
    4 CMe NH Q1k a bond Me a bond NH O a bond Q3f OH
    5 CMe NH Q1k a bond Me a bond NH O NH Q3a OH
    6 CMe NH Q1k a bond Me a bond NH O NH Q3d OH
    7 CMe NH Q1k a bond Me a bond NH O NH Q3e OH
    8 CMe NH Q1k a bond Me a bond NH O NH Q3f OH
    9 CMe NH Q1k a bond Me a bond NH S a bond Q3a OH
    10 CMe NH Q1k a bond Me a bond NH S a bond Q3d OH
    11 CMe NH Q1k a bond Me a bond NH S a bond Q3e OH
    12 CMe NH Q1k a bond Me a bond NH S a bond Q3f OH
    13 CMe NH Q1k a bond Me a bond NH S NH Q3a OH
    14 CMe NH Q1k a bond Me a bond NH S NH Q3d OH
    15 CMe NH Q1k a bond Me a bond NH S NH Q3e OH
    16 CMe NH Q1k a bond Me a bond NH S NH Q3f OH
    17 CMe NH Q1l a bond Me a bond NH O a bond Q3a OH
    18 CMe NH Q1l a bond Me a bond NH O a bond Q3d OH
    19 CMe NH Q1l a bond Me a bond NH O a bond Q3e OH
    20 CMe NH Q1l a bond Me a bond NH O a bond Q3f OH
    21 CMe NH Q1l a bond Me a bond NH O NH Q3a OH
    22 CMe NH Q1l a bond Me a bond NH O NH Q3d OH
    23 CMe NH Q1l a bond Me a bond NH O NH Q3e OH
    24 CMe NH Q1l a bond Me a bond NH O NH Q3f OH
    25 CMe NH Q1l a bond Me a bond NH S a bond Q3a OH
    26 CMe NH Q1l a bond Me a bond NH S a bond Q3d OH
    27 CMe NH Q1l a bond Me a bond NH S a bond Q3e OH
    28 CMe NH Q1l a bond Me a bond NH S a bond Q3f OH
    29 CMe NH Q1l a bond Me a bond NH S NH Q3a OH
    30 CMe NH Q1l a bond Me a bond NH S NH Q3d OH
    31 CMe NH Q1l a bond Me a bond NH S NH Q3e OH
    32 CMe NH Q1l a bond Me a bond NH S NH Q3f OH
    33 CMe NH Q1m a bond Me a bond NH O a bond Q3a OH
    34 CMe NH Q1m a bond Me a bond NH O a bond Q3d OH
    35 CMe NH Q1m a bond Me a bond NH O a bond Q3e OH
    36 CMe NH Q1m a bond Me a bond NH O a bond Q3f OH
    37 CMe NH Q1m a bond Me a bond NH O NH Q3a OH
    38 CMe NH Q1m a bond Me a bond NH O NH Q3d OH
    39 CMe NH Q1m a bond Me a bond NH O NH Q3e OH
    40 CMe NH Q1m a bond Me a bond NH O NH Q3f OH
    41 CMe NH Q1m a bond Me a bond NH S a bond Q3a OH
    42 CMe NH Q1m a bond Me a bond NH S a bond Q3d OH
    43 CMe NH Q1m a bond Me a bond NH S a bond Q3e OH
    44 CMe NH Q1m a bond Me a bond NH S a bond Q3f OH
    45 CMe NH Q1m a bond Me a bond NH S NH Q3a OH
    46 CMe NH Q1m a bond Me a bond NH S NH Q3d OH
    47 CMe NH Q1m a bond Me a bond NH S NH Q3e OH
    48 CMe NH Q1m a bond Me a bond NH S NH Q3f OH
    49 CMe NH Q1n a bond Me a bond NH O a bond Q3a OH
    50 CMe NH Q1n a bond Me a bond NH O a bond Q3d OH
    51 CMe NH Q1n a bond Me a bond NH O a bond Q3e OH
    52 CMe NH Q1n a bond Me a bond NH O a bond Q3f OH
    53 CMe NH Q1n a bond Me a bond NH O NH Q3a OH
    54 CMe NH Q1n a bond Me a bond NH O NH Q3d OH
    55 CMe NH Q1n a bond Me a bond NH O NH Q3e OH
    56 CMe NH Q1n a bond Me a bond NH O NH Q3f OH
    57 CMe NH Q1n a bond Me a bond NH S a bond Q3a OH
    58 CMe NH Q1n a bond Me a bond NH S a bond Q3d OH
    59 CMe NH Q1n a bond Me a bond NH S a bond Q3e OH
    60 CMe NH Q1n a bond Me a bond NH S a bond Q3f OH
    61 CMe NH Q1n a bond Me a bond NH S NH Q3a OH
    62 CMe NH Q1n a bond Me a bond NH S NH Q3d OH
    63 CMe NH Q1n a bond Me a bond NH S NH Q3e OH
    64 CMe NH Q1n a bond Me a bond NH S NH Q3f OH
    65 CMe NH Q1k′ a bond Me a bond NH O a bond Q3a OH
    66 CMe NH Q1k′ a bond Me a bond NH O a bond Q3d OH
    67 CMe NH Q1k′ a bond Me a bond NH O a bond Q3e OH
    68 CMe NH Q1k′ a bond Me a bond NH O a bond Q3f OH
    69 CMe NH Q1k′ a bond Me a bond NH O NH Q3a OH
    70 CMe NH Q1k′ a bond Me a bond NH O NH Q3d OH
    71 CMe NH Q1k′ a bond Me a bond NH O NH Q3e OH
    72 CMe NH Q1k′ a bond Me a bond NH O NH Q3f OH
    73 CMe NH Q1k′ a bond Me a bond NH S a bond Q3a OH
    74 CMe NH Q1k′ a bond Me a bond NH S a bond Q3d OH
    75 CMe NH Q1k′ a bond Me a bond NH S a bond Q3e OH
    76 CMe NH Q1k′ a bond Me a bond NH S a bond Q3f OH
    77 CMe NH Q1k′ a bond Me a bond NH S NH Q3a OH
    78 CMe NH Q1k′ a bond Me a bond NH S NH Q3d OH
    79 CMe NH Q1k′ a bond Me a bond NH S NH Q3e OH
    80 CMe NH Q1k′ a bond Me a bond NH S NH Q3f OH
    81 CMe NH Q1l′ a bond Me a bond NH O a bond Q3a OH
    82 CMe NH Q1l′ a bond Me a bond NH O a bond Q3d OH
    83 CMe NH Q1l′ a bond Me a bond NH O a bond Q3e OH
    84 CMe NH Q1l′ a bond Me a bond NH O a bond Q3f OH
    85 CMe NH Q1l′ a bond Me a bond NH O NH Q3a OH
    86 CMe NH Q1l′ a bond Me a bond NH O NH Q3d OH
    87 CMe NH Q1l′ a bond Me a bond NH O NH Q3e OH
    88 CMe NH Q1l′ a bond Me a bond NH O NH Q3f OH
    89 CMe NH Q1l′ a bond Me a bond NH S a bond Q3a OH
    90 CMe NH Q1l′ a bond Me a bond NH S a bond Q3d OH
    91 CMe NH Q1l′ a bond Me a bond NH S a bond Q3e OH
    92 CMe NH Q1l′ a bond Me a bond NH S a bond Q3f OH
    93 CMe NH Q1l′ a bond Me a bond NH S NH Q3a OH
    94 CMe NH Q1l′ a bond Me a bond NH S NH Q3d OH
    95 CMe NH Q1l′ a bond Me a bond NH S NH Q3e OH
    96 CMe NH Q1l′ a bond Me a bond NH S NH Q3f OH
    97 CMe NH Q1m′ a bond Me a bond NH O a bond Q3a OH
    98 CMe NH Q1m′ a bond Me a bond NH O a bond Q3d OH
    99 CMe NH Q1m′ a bond Me a bond NH O a bond Q3e OH
    100 CMe NH Q1m′ a bond Me a bond NH O a bond Q3f OH
    101 CMe NH Q1m′ a bond Me a bond NH O NH Q3a OH
    102 CMe NH Q1m′ a bond Me a bond NH O NH Q3d OH
    103 CMe NH Q1m′ a bond Me a bond NH O NH Q3e OH
    104 CMe NH Q1m′ a bond Me a bond NH O NH Q3f OH
    105 CMe NH Q1m′ a bond Me a bond NH S a bond Q3a OH
    106 CMe NH Q1m′ a bond Me a bond NH S a bond Q3d OH
    107 CMe NH Q1m′ a bond Me a bond NH S a bond Q3e OH
    108 CMe NH Q1m′ a bond Me a bond NH S a bond Q3f OH
    109 CMe NH Q1m′ a bond Me a bond NH S NH Q3a OH
    110 CMe NH Q1m′ a bond Me a bond NH S NH Q3d OH
    111 CMe NH Q1m′ a bond Me a bond NH S NH Q3e OH
    112 CMe NH Q1m′ a bond Me a bond NH S NH Q3f OH
    113 CMe NH Q1n′ a bond Me a bond NH O a bond Q3a OH
    114 CMe NH Q1n′ a bond Me a bond NH O a bond Q3d OH
    115 CMe NH Q1n′ a bond Me a bond NH O a bond Q3e OH
    116 CMe NH Q1n′ a bond Me a bond NH O a bond Q3f OH
    117 CMe NH Q1n′ a bond Me a bond NH O NH Q3a OH
    118 CMe NH Q1n′ a bond Me a bond NH O NH Q3d OH
    119 CMe NH Q1n′ a bond Me a bond NH O NH Q3e OH
    120 CMe NH Q1n′ a bond Me a bond NH O NH Q3f OH
    121 CMe NH Q1n′ a bond Me a bond NH S a bond Q3a OH
    122 CMe NH Q1n′ a bond Me a bond NH S a bond Q3d OH
    123 CMe NH Q1n′ a bond Me a bond NH S a bond Q3e OH
    124 CMe NH Q1n′ a bond Me a bond NH S a bond Q3f OH
    125 CMe NH Q1n′ a bond Me a bond NH S NH Q3a OH
    126 CMe NH Q1n′ a bond Me a bond NH S NH Q3d OH
    127 CMe NH Q1n′ a bond Me a bond NH S NH Q3e OH
    128 CMe NH Q1n′ a bond Me a bond NH S NH Q3f OH
    129 CMe NH Q1a a bond Me a bond NH O a bond Q3d OH
    130 CMe NH Q1a a bond Me a bond NH O a bond Q3e OH
    131 CMe NH Q1a a bond Me a bond NH O a bond Q3f OH
    132 CMe NH Q1a a bond Me a bond NH O NH Q3d OH
    133 CMe NH Q1a a bond Me a bond NH O NH Q3e OH
    134 CMe NH Q1a a bond Me a bond NH O NH Q3f OH
    135 CMe NH Q1a a bond Me a bond NH S a bond Q3d OH
    136 CMe NH Q1a a bond Me a bond NH S a bond Q3e OH
    137 CMe NH Q1a a bond Me a bond NH S a bond Q3f OH
    138 CMe NH Q1a a bond Me a bond NH S NH Q3d OH
    139 CMe NH Q1a a bond Me a bond NH S NH Q3e OH
    140 CMe NH Q1a a bond Me a bond NH S NH Q3f OH
    141 CMe NH Q1b a bond Me a bond NH O a bond Q3d OH
    142 CMe NH Q1b a bond Me a bond NH O a bond Q3e OH
    143 CMe NH Q1b a bond Me a bond NH O a bond Q3f OH
    144 CMe NH Q1b a bond Me a bond NH O NH Q3d OH
    145 CMe NH Q1b a bond Me a bond NH O NH Q3e OH
    146 CMe NH Q1b a bond Me a bond NH O NH Q3f OH
    147 CMe NH Q1b a bond Me a bond NH S a bond Q3d OH
    148 CMe NH Q1b a bond Me a bond NH S a bond Q3e OH
    149 CMe NH Q1b a bond Me a bond NH S a bond Q3f OH
    150 CMe NH Q1b a bond Me a bond NH S NH Q3d OH
    151 CMe NH Q1b a bond Me a bond NH S NH Q3e OH
    152 CMe NH Q1b a bond Me a bond NH S NH Q3f OH
    153 CMe NH Q1c a bond Me a bond NH O a bond Q3d OH
    154 CMe NH Q1c a bond Me a bond NH O a bond Q3e OH
    155 CMe NH Q1c a bond Me a bond NH O a bond Q3f OH
    156 CMe NH Q1c a bond Me a bond NH O NH Q3d OH
    157 CMe NH Q1c a bond Me a bond NH O NH Q3e OH
    158 CMe NH Q1c a bond Me a bond NH O NH Q3f OH
    159 CMe NH Q1c a bond Me a bond NH S a bond Q3d OH
    160 CMe NH Q1c a bond Me a bond NH S a bond Q3e OH
    161 CMe NH Q1c a bond Me a bond NH S a bond Q3f OH
    162 CMe NH Q1c a bond Me a bond NH S NH Q3d OH
    163 CMe NH Q1c a bond Me a bond NH S NH Q3e OH
    164 CMe NH Q1a a bond Me a bond NH S NH Q3g OH
    165 CMe NH Q1a a bond Me a bond NH S NH Q3h OH
    166 CMe NH Q1b a bond Me a bond NH S NH Q3g OH
    167 CMe NH Q1b a bond Me a bond NH S NH Q3h OH
    168 CMe NH Q1c a bond Me a bond NH S NH Q3g OH
    169 CMe NH Q1c a bond Me a bond NH S NH Q3h OH
    170 CMe NH Q1a a bond Me a bond NH O a bond Q3g OH
    171 CMe NH Q1a a bond Me a bond NH O a bond Q3h OH
    172 CMe NH Q1b a bond Me a bond NH O a bond Q3g OH
    173 CMe NH Q1b a bond Me a bond NH O a bond Q3h OH
    174 CMe NH Q1c a bond Me a bond NH S a bond Q3g OH
    175 CMe NH Q1c a bond Me a bond NH S a bond Q3h OH
    176 CMe NH Q1c a bond Me a bond NH S NH Q3f OH
  • 73) The compounds wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof. The symbols in Table 6 denote the following substituents.
  • Figure US20140051857A1-20140220-C00011
    Figure US20140051857A1-20140220-C00012
  • TABLE 6
    No A B R1 L1 R2 L2 L3 Y L4 R3 X
    1 N NMe Q1a a bond Me a bond NH S NH T3a OH
    2 N NMe Q1a a bond Me a bond NH S NH T3b OH
    3 N NMe Q1a a bond Me a bond NH S NH T3c OH
    4 N NMe Q1a a bond Me a bond NH S NH T3d OH
    5 N NMe Q1a a bond Me a bond NH S NH T3e OH
    6 N NMe Q1a a bond Me a bond NH S NH T3f OH
    7 N NMe Q1a a bond Me a bond NH S NH T3g OH
    8 N NMe Q1a a bond Me a bond NH S NH T3h OH
    9 N NMe Q1a a bond Me a bond NH S NH T3i OH
    10 N NMe Q1a a bond Me a bond NH S NH T3j OH
    11 N NMe Q1a a bond Me a bond NH S a bond T3a OH
    12 N NMe Q1a a bond Me a bond NH S a bond T3b OH
    13 N NMe Q1a a bond Me a bond NH S a bond T3c OH
    14 N NMe Q1a a bond Me a bond NH S a bond T3d OH
    15 N NMe Q1a a bond Me a bond NH S a bond T3e OH
    16 N NMe Q1a a bond Me a bond NH S a bond T3f OH
    17 N NMe Q1a a bond Me a bond NH S a bond T3g OH
    18 N NMe Q1a a bond Me a bond NH S a bond T3h OH
    19 N NMe Q1a a bond Me a bond NH S a bond T3i OH
    20 N NMe Q1a a bond Me a bond NH S a bond T3j OH
    21 N NMe Q1a a bond Me a bond NH O NH T3a OH
    22 N NMe Q1a a bond Me a bond NH O NH T3b OH
    23 N NMe Q1a a bond Me a bond NH O NH T3c OH
    24 N NMe Q1a a bond Me a bond NH O NH T3d OH
    25 N NMe Q1a a bond Me a bond NH O NH T3e OH
    26 N NMe Q1a a bond Me a bond NH O NH T3f OH
    27 N NMe Q1a a bond Me a bond NH O NH T3g OH
    28 N NMe Q1a a bond Me a bond NH O NH T3h OH
    29 N NMe Q1a a bond Me a bond NH O NH T3i OH
    30 N NMe Q1a a bond Me a bond NH O NH T3j OH
    31 N NMe Q1a a bond Me a bond NH O a bond T3a OH
    32 N NMe Q1a a bond Me a bond NH O a bond T3b OH
    33 N NMe Q1a a bond Me a bond NH O a bond T3c OH
    34 N NMe Q1a a bond Me a bond NH O a bond T3d OH
    35 N NMe Q1a a bond Me a bond NH O a bond T3e OH
    36 N NMe Q1a a bond Me a bond NH O a bond T3f OH
    37 N NMe Q1a a bond Me a bond NH O a bond T3g OH
    38 N NMe Q1a a bond Me a bond NH O a bond T3h OH
    39 N NMe Q1a a bond Me a bond NH O a bond T3i OH
    40 N NMe Q1a a bond Me a bond NH O a bond T3j OH
    41 N NMe Q1a a bond H a bond NH S NH T3a OH
    42 N NMe Q1a a bond H a bond NH S NH T3b OH
    43 N NMe Q1a a bond H a bond NH S NH T3c OH
    44 N NMe Q1a a bond H a bond NH S NH T3d OH
    45 N NMe Q1a a bond H a bond NH S NH T3e OH
    46 N NMe Q1a a bond H a bond NH S NH T3f OH
    47 N NMe Q1a a bond H a bond NH S NH T3g OH
    48 N NMe Q1a a bond H a bond NH S NH T3h OH
    49 N NMe Q1a a bond H a bond NH S NH T3i OH
    50 N NMe Q1a a bond H a bond NH S NH T3j OH
    51 N NMe Q1a a bond H a bond NH S a bond T3a OH
    52 N NMe Q1a a bond H a bond NH S a bond T3b OH
    53 N NMe Q1a a bond H a bond NH S a bond T3c OH
    54 N NMe Q1a a bond H a bond NH S a bond T3d OH
    55 N NMe Q1a a bond H a bond NH S a bond T3e OH
    56 N NMe Q1a a bond H a bond NH S a bond T3f OH
    57 N NMe Q1a a bond H a bond NH S a bond T3g OH
    58 N NMe Q1a a bond H a bond NH S a bond T3h OH
    59 N NMe Q1a a bond H a bond NH S a bond T3i OH
    60 N NMe Q1a a bond H a bond NH S a bond T3j OH
    61 N NMe Q1a a bond H a bond NH O NH T3a OH
    62 N NMe Q1a a bond H a bond NH O NH T3b OH
    63 N NMe Q1a a bond H a bond NH O NH T3c OH
    64 N NMe Q1a a bond H a bond NH O NH T3d OH
    65 N NMe Q1a a bond H a bond NH O NH T3e OH
    66 N NMe Q1a a bond H a bond NH O NH T3f OH
    67 N NMe Q1a a bond H a bond NH O NH T3g OH
    68 N NMe Q1a a bond H a bond NH O NH T3h OH
    69 N NMe Q1a a bond H a bond NH O NH T3i OH
    70 N NMe Q1a a bond H a bond NH O NH T3j OH
    71 N NMe Q1a a bond H a bond NH O a bond T3a OH
    72 N NMe Q1a a bond H a bond NH O a bond T3b OH
    73 N NMe Q1a a bond H a bond NH O a bond T3c OH
    74 N NMe Q1a a bond H a bond NH O a bond T3d OH
    75 N NMe Q1a a bond H a bond NH O a bond T3e OH
    76 N NMe Q1a a bond H a bond NH O a bond T3f OH
    77 N NMe Q1a a bond H a bond NH O a bond T3g OH
    78 N NMe Q1a a bond H a bond NH O a bond T3h OH
    79 N NMe Q1a a bond H a bond NH O a bond T3i OH
    80 N NMe Q1a a bond H a bond NH O a bond T3j OH
    81 N NMe Q1b a bond Me a bond NH S NH T3a OH
    82 N NMe Q1b a bond Me a bond NH S NH T3b OH
    83 N NMe Q1b a bond Me a bond NH S NH T3c OH
    84 N NMe Q1b a bond Me a bond NH S NH T3d OH
    85 N NMe Q1b a bond Me a bond NH S NH T3e OH
    86 N NMe Q1b a bond Me a bond NH S NH T3f OH
    87 N NMe Q1b a bond Me a bond NH S NH T3g OH
    88 N NMe Q1b a bond Me a bond NH S NH T3h OH
    89 N NMe Q1b a bond Me a bond NH S NH T3i OH
    90 N NMe Q1b a bond Me a bond NH S NH T3j OH
    91 N NMe Q1b a bond Me a bond NH S a bond T3a OH
    92 N NMe Q1b a bond Me a bond NH S a bond T3b OH
    93 N NMe Q1b a bond Me a bond NH S a bond T3c OH
    94 N NMe Q1b a bond Me a bond NH S a bond T3d OH
    95 N NMe Q1b a bond Me a bond NH S a bond T3e OH
    96 N NMe Q1b a bond Me a bond NH S a bond T3f OH
    97 N NMe Q1b a bond Me a bond NH S a bond T3g OH
    98 N NMe Q1b a bond Me a bond NH S a bond T3h OH
    99 N NMe Q1b a bond Me a bond NH S a bond T3i OH
    100 N NMe Q1b a bond Me a bond NH S a bond T3j OH
    101 N NMe Q1b a bond Me a bond NH O NH T3a OH
    102 N NMe Q1b a bond Me a bond NH O NH T3b OH
    103 N NMe Q1b a bond Me a bond NH O NH T3c OH
    104 N NMe Q1b a bond Me a bond NH O NH T3d OH
    105 N NMe Q1b a bond Me a bond NH O NH T3e OH
    106 N NMe Q1b a bond Me a bond NH O NH T3f OH
    107 N NMe Q1b a bond Me a bond NH O NH T3g OH
    108 N NMe Q1b a bond Me a bond NH O NH T3h OH
    109 N NMe Q1b a bond Me a bond NH O NH T3i OH
    110 N NMe Q1b a bond Me a bond NH O NH T3j OH
    111 N NMe Q1b a bond Me a bond NH O a bond T3a OH
    112 N NMe Q1b a bond Me a bond NH O a bond T3b OH
    113 N NMe Q1b a bond Me a bond NH O a bond T3c OH
    114 N NMe Q1b a bond Me a bond NH O a bond T3d OH
    115 N NMe Q1b a bond Me a bond NH O a bond T3e OH
    116 N NMe Q1b a bond Me a bond NH O a bond T3f OH
    117 N NMe Q1b a bond Me a bond NH O a bond T3g OH
    118 N NMe Q1b a bond Me a bond NH O a bond T3h OH
    119 N NMe Q1b a bond Me a bond NH O a bond T3i OH
    120 N NMe Q1b a bond Me a bond NH O a bond T3j OH
    121 N NMe Q1b a bond H a bond NH S NH T3a OH
    122 N NMe Q1b a bond H a bond NH S NH T3b OH
    123 N NMe Q1b a bond H a bond NH S NH T3c OH
    124 N NMe Q1b a bond H a bond NH S NH T3d OH
    125 N NMe Q1b a bond H a bond NH S NH T3e OH
    126 N NMe Q1b a bond H a bond NH S NH T3f OH
    127 N NMe Q1b a bond H a bond NH S NH T3g OH
    128 N NMe Q1b a bond H a bond NH S NH T3h OH
    129 N NMe Q1b a bond H a bond NH S NH T3i OH
    130 N NMe Q1b a bond H a bond NH S NH T3j OH
    131 N NMe Q1b a bond H a bond NH S a bond T3a OH
    132 N NMe Q1b a bond H a bond NH S a bond T3b OH
    133 N NMe Q1b a bond H a bond NH S a bond T3c OH
    134 N NMe Q1b a bond H a bond NH S a bond T3d OH
    135 N NMe Q1b a bond H a bond NH S a bond T3e OH
    136 N NMe Q1b a bond H a bond NH S a bond T3f OH
    137 N NMe Q1b a bond H a bond NH S a bond T3g OH
    138 N NMe Q1b a bond H a bond NH S a bond T3h OH
    139 N NMe Q1b a bond H a bond NH S a bond T3i OH
    140 N NMe Q1b a bond H a bond NH S a bond T3j OH
    141 N NMe Q1b a bond H a bond NH O NH T3a OH
    142 N NMe Q1b a bond H a bond NH O NH T3b OH
    143 N NMe Q1b a bond H a bond NH O NH T3c OH
    144 N NMe Q1b a bond H a bond NH O NH T3d OH
    145 N NMe Q1b a bond H a bond NH O NH T3e OH
    146 N NMe Q1b a bond H a bond NH O NH T3f OH
    147 N NMe Q1b a bond H a bond NH O NH T3g OH
    148 N NMe Q1b a bond H a bond NH O NH T3h OH
    149 N NMe Q1b a bond H a bond NH O NH T3i OH
    150 N NMe Q1b a bond H a bond NH O NH T3j OH
    151 N NMe Q1b a bond H a bond NH O a bond T3a OH
    152 N NMe Q1b a bond H a bond NH O a bond T3b OH
    153 N NMe Q1b a bond H a bond NH O a bond T3c OH
    154 N NMe Q1b a bond H a bond NH O a bond T3d OH
    155 N NMe Q1b a bond H a bond NH O a bond T3e OH
    156 N NMe Q1b a bond H a bond NH O a bond T3f OH
    157 N NMe Q1b a bond H a bond NH O a bond T3g OH
    158 N NMe Q1b a bond H a bond NH O a bond T3h OH
    159 N NMe Q1b a bond H a bond NH O a bond T3i OH
    160 N NMe Q1b a bond H a bond NH O a bond T3j OH
    161 N NMe Q1c a bond Me a bond NH S NH T3a OH
    162 N NMe Q1c a bond Me a bond NH S NH T3b OH
    163 N NMe Q1c a bond Me a bond NH S NH T3c OH
    164 N NMe Q1c a bond Me a bond NH S NH T3d OH
    165 N NMe Q1c a bond Me a bond NH S NH T3e OH
    166 N NMe Q1c a bond Me a bond NH S NH T3f OH
    167 N NMe Q1c a bond Me a bond NH S NH T3g OH
    168 N NMe Q1c a bond Me a bond NH S NH T3h OH
    169 N NMe Q1c a bond Me a bond NH S NH T3i OH
    170 N NMe Q1c a bond Me a bond NH S NH T3j OH
    171 N NMe Q1c a bond Me a bond NH S a bond T3a OH
    172 N NMe Q1c a bond Me a bond NH S a bond T3b OH
    173 N NMe Q1c a bond Me a bond NH S a bond T3c OH
    174 N NMe Q1c a bond Me a bond NH S a bond T3d OH
    175 N NMe Q1c a bond Me a bond NH S a bond T3e OH
    176 N NMe Q1c a bond Me a bond NH S a bond T3f OH
    177 N NMe Q1c a bond Me a bond NH S a bond T3g OH
    178 N NMe Q1c a bond Me a bond NH S a bond T3h OH
    179 N NMe Q1c a bond Me a bond NH S a bond T3i OH
    180 N NMe Q1c a bond Me a bond NH S a bond T3j OH
    181 N NMe Q1c a bond Me a bond NH O NH T3a OH
    182 N NMe Q1c a bond Me a bond NH O NH T3b OH
    183 N NMe Q1c a bond Me a bond NH O NH T3c OH
    184 N NMe Q1c a bond Me a bond NH O NH T3d OH
    185 N NMe Q1c a bond Me a bond NH O NH T3e OH
    186 N NMe Q1c a bond Me a bond NH O NH T3f OH
    187 N NMe Q1c a bond Me a bond NH O NH T3g OH
    188 N NMe Q1c a bond Me a bond NH O NH T3h OH
    189 N NMe Q1c a bond Me a bond NH O NH T3i OH
    190 N NMe Q1c a bond Me a bond NH O NH T3j OH
    191 N NMe Q1c a bond Me a bond NH O a bond T3a OH
    192 N NMe Q1c a bond Me a bond NH O a bond T3b OH
    193 N NMe Q1c a bond Me a bond NH O a bond T3c OH
    194 N NMe Q1c a bond Me a bond NH O a bond T3d OH
    195 N NMe Q1c a bond Me a bond NH O a bond T3e OH
    196 N NMe Q1c a bond Me a bond NH O a bond T3f OH
    197 N NMe Q1c a bond Me a bond NH O a bond T3g OH
    198 N NMe Q1c a bond Me a bond NH O a bond T3h OH
    199 N NMe Q1c a bond Me a bond NH O a bond T3i OH
    200 N NMe Q1c a bond Me a bond NH O a bond T3j OH
    201 N NMe Q1c a bond H a bond NH S NH T3a OH
    202 N NMe Q1c a bond H a bond NH S NH T3b OH
    203 N NMe Q1c a bond H a bond NH S NH T3c OH
    204 N NMe Q1c a bond H a bond NH S NH T3d OH
    205 N NMe Q1c a bond H a bond NH S NH T3e OH
    206 N NMe Q1c a bond H a bond NH S NH T3f OH
    207 N NMe Q1c a bond H a bond NH S NH T3g OH
    208 N NMe Q1c a bond H a bond NH S NH T3h OH
    209 N NMe Q1c a bond H a bond NH S NH T3i OH
    210 N NMe Q1c a bond H a bond NH S NH T3j OH
    211 N NMe Q1c a bond H a bond NH S a bond T3a OH
    212 N NMe Q1c a bond H a bond NH S a bond T3b OH
    213 N NMe Q1c a bond H a bond NH S a bond T3c OH
    214 N NMe Q1c a bond H a bond NH S a bond T3d OH
    215 N NMe Q1c a bond H a bond NH S a bond T3e OH
    216 N NMe Q1c a bond H a bond NH S a bond T3f OH
    217 N NMe Q1c a bond H a bond NH S a bond T3g OH
    218 N NMe Q1c a bond H a bond NH S a bond T3h OH
    219 N NMe Q1c a bond H a bond NH S a bond T3i OH
    220 N NMe Q1c a bond H a bond NH S a bond T3j OH
    221 N NMe Q1c a bond H a bond NH O NH T3a OH
    222 N NMe Q1c a bond H a bond NH O NH T3b OH
    223 N NMe Q1c a bond H a bond NH O NH T3c OH
    224 N NMe Q1c a bond H a bond NH O NH T3d OH
    225 N NMe Q1c a bond H a bond NH O NH T3e OH
    226 N NMe Q1c a bond H a bond NH O NH T3f OH
    227 N NMe Q1c a bond H a bond NH O NH T3g OH
    228 N NMe Q1c a bond H a bond NH O NH T3h OH
    229 N NMe Q1c a bond H a bond NH O NH T3i OH
    230 N NMe Q1c a bond H a bond NH O NH T3j OH
    231 N NMe Q1c a bond H a bond NH O a bond T3a OH
    232 N NMe Q1c a bond H a bond NH O a bond T3b OH
    233 N NMe Q1c a bond H a bond NH O a bond T3c OH
    234 N NMe Q1c a bond H a bond NH O a bond T3d OH
    235 N NMe Q1c a bond H a bond NH O a bond T3e OH
    236 N NMe Q1c a bond H a bond NH O a bond T3f OH
    237 N NMe Q1c a bond H a bond NH O a bond T3g OH
    238 N NMe Q1c a bond H a bond NH O a bond T3h OH
    239 N NMe Q1c a bond H a bond NH O a bond T3i OH
    240 N NMe Q1c a bond H a bond NH O a bond T3j OH
    241 N NMe Q1i a bond Me a bond NH S NH T3a OH
    242 N NMe Q1i a bond Me a bond NH S NH T3b OH
    243 N NMe Q1i a bond Me a bond NH S NH T3c OH
    244 N NMe Q1i a bond Me a bond NH S NH T3d OH
    245 N NMe Q1i a bond Me a bond NH S NH T3e OH
    246 N NMe Q1i a bond Me a bond NH S NH T3f OH
    247 N NMe Q1i a bond Me a bond NH S NH T3g OH
    248 N NMe Q1i a bond Me a bond NH S NH T3h OH
    249 N NMe Q1i a bond Me a bond NH S NH T3i OH
    250 N NMe Q1i a bond Me a bond NH S NH T3j OH
    251 N NMe Q1i a bond Me a bond NH S a bond T3a OH
    252 N NMe Q1i a bond Me a bond NH S a bond T3b OH
    253 N NMe Q1i a bond Me a bond NH S a bond T3c OH
    254 N NMe Q1i a bond Me a bond NH S a bond T3d OH
    255 N NMe Q1i a bond Me a bond NH S a bond T3e OH
    256 N NMe Q1i a bond Me a bond NH S a bond T3f OH
    257 N NMe Q1i a bond Me a bond NH S a bond T3g OH
    258 N NMe Q1i a bond Me a bond NH S a bond T3h OH
    259 N NMe Q1i a bond Me a bond NH S a bond T3i OH
    260 N NMe Q1i a bond Me a bond NH S a bond T3j OH
    261 N NMe Q1i a bond Me a bond NH O NH T3a OH
    262 N NMe Q1i a bond Me a bond NH O NH T3b OH
    263 N NMe Q1i a bond Me a bond NH O NH T3c OH
    264 N NMe Q1i a bond Me a bond NH O NH T3d OH
    265 N NMe Q1i a bond Me a bond NH O NH T3e OH
    266 N NMe Q1i a bond Me a bond NH O NH T3f OH
    267 N NMe Q1i a bond Me a bond NH O NH T3g OH
    268 N NMe Q1i a bond Me a bond NH O NH T3h OH
    269 N NMe Q1i a bond Me a bond NH O NH T3i OH
    270 N NMe Q1i a bond Me a bond NH O NH T3j OH
    271 N NMe Q1i a bond Me a bond NH O a bond T3a OH
    272 N NMe Q1i a bond Me a bond NH O a bond T3b OH
    273 N NMe Q1i a bond Me a bond NH O a bond T3c OH
    274 N NMe Q1i a bond Me a bond NH O a bond T3d OH
    275 N NMe Q1i a bond Me a bond NH O a bond T3e OH
    276 N NMe Q1i a bond Me a bond NH O a bond T3f OH
    277 N NMe Q1i a bond Me a bond NH O a bond T3g OH
    278 N NMe Q1i a bond Me a bond NH O a bond T3h OH
    279 N NMe Q1i a bond Me a bond NH O a bond T3i OH
    280 N NMe Q1i a bond Me a bond NH O a bond T3j OH
    281 N NMe Q1i a bond H a bond NH S NH T3a OH
    282 N NMe Q1i a bond H a bond NH S NH T3b OH
    283 N NMe Q1i a bond H a bond NH S NH T3c OH
    284 N NMe Q1i a bond H a bond NH S NH T3d OH
    285 N NMe Q1i a bond H a bond NH S NH T3e OH
    286 N NMe Q1i a bond H a bond NH S NH T3f OH
    287 N NMe Q1i a bond H a bond NH S NH T3g OH
    288 N NMe Q1i a bond H a bond NH S NH T3h OH
    289 N NMe Q1i a bond H a bond NH S NH T3i OH
    290 N NMe Q1i a bond H a bond NH S NH T3j OH
    291 N NMe Q1i a bond H a bond NH S a bond T3a OH
    292 N NMe Q1i a bond H a bond NH S a bond T3b OH
    293 N NMe Q1i a bond H a bond NH S a bond T3c OH
    294 N NMe Q1i a bond H a bond NH S a bond T3d OH
    295 N NMe Q1i a bond H a bond NH S a bond T3e OH
    296 N NMe Q1i a bond H a bond NH S a bond T3f OH
    297 N NMe Q1i a bond H a bond NH S a bond T3g OH
    298 N NMe Q1i a bond H a bond NH S a bond T3h OH
    299 N NMe Q1i a bond H a bond NH S a bond T3i OH
    300 N NMe Q1i a bond H a bond NH S a bond T3j OH
    301 N NMe Q1i a bond H a bond NH O NH T3a OH
    302 N NMe Q1i a bond H a bond NH O NH T3b OH
    303 N NMe Q1i a bond H a bond NH O NH T3c OH
    304 N NMe Q1i a bond H a bond NH O NH T3d OH
    305 N NMe Q1i a bond H a bond NH O NH T3e OH
    306 N NMe Q1i a bond H a bond NH O NH T3f OH
    307 N NMe Q1i a bond H a bond NH O NH T3g OH
    308 N NMe Q1i a bond H a bond NH O NH T3h OH
    309 N NMe Q1i a bond H a bond NH O NH T3i OH
    310 N NMe Q1i a bond H a bond NH O NH T3j OH
    311 N NMe Q1i a bond H a bond NH O a bond T3a OH
    312 N NMe Q1i a bond H a bond NH O a bond T3b OH
    313 N NMe Q1i a bond H a bond NH O a bond T3c OH
    314 N NMe Q1i a bond H a bond NH O a bond T3d OH
    315 N NMe Q1i a bond H a bond NH O a bond T3e OH
    316 N NMe Q1i a bond H a bond NH O a bond T3f OH
    317 N NMe Q1i a bond H a bond NH O a bond T3g OH
    318 N NMe Q1i a bond H a bond NH O a bond T3h OH
    319 N NMe Q1i a bond H a bond NH O a bond T3i OH
    320 N NMe Q1i a bond H a bond NH O a bond T3j OH
    321 N NMe Q1j a bond Me a bond NH S NH T3a OH
    322 N NMe Q1j a bond Me a bond NH S NH T3b OH
    323 N NMe Q1j a bond Me a bond NH S NH T3c OH
    324 N NMe Q1j a bond Me a bond NH S NH T3d OH
    325 N NMe Q1j a bond Me a bond NH S NH T3e OH
    326 N NMe Q1j a bond Me a bond NH S NH T3f OH
    327 N NMe Q1j a bond Me a bond NH S NH T3g OH
    328 N NMe Q1j a bond Me a bond NH S NH T3h OH
    329 N NMe Q1j a bond Me a bond NH S NH T3i OH
    330 N NMe Q1j a bond Me a bond NH S NH T3j OH
    331 N NMe Q1j a bond Me a bond NH S a bond T3a OH
    332 N NMe Q1j a bond Me a bond NH S a bond T3b OH
    333 N NMe Q1j a bond Me a bond NH S a bond T3c OH
    334 N NMe Q1j a bond Me a bond NH S a bond T3d OH
    335 N NMe Q1j a bond Me a bond NH S a bond T3e OH
    336 N NMe Q1j a bond Me a bond NH S a bond T3f OH
    337 N NMe Q1j a bond Me a bond NH S a bond T3g OH
    338 N NMe Q1j a bond Me a bond NH S a bond T3h OH
    339 N NMe Q1j a bond Me a bond NH S a bond T3i OH
    340 N NMe Q1j a bond Me a bond NH S a bond T3j OH
    341 N NMe Q1j a bond Me a bond NH O NH T3a OH
    342 N NMe Q1j a bond Me a bond NH O NH T3b OH
    343 N NMe Q1j a bond Me a bond NH O NH T3c OH
    344 N NMe Q1j a bond Me a bond NH O NH T3d OH
    345 N NMe Q1j a bond Me a bond NH O NH T3e OH
    346 N NMe Q1j a bond Me a bond NH O NH T3f OH
    347 N NMe Q1j a bond Me a bond NH O NH T3g OH
    348 N NMe Q1j a bond Me a bond NH O NH T3h OH
    349 N NMe Q1j a bond Me a bond NH O NH T3i OH
    350 N NMe Q1j a bond Me a bond NH O NH T3j OH
    351 N NMe Q1j a bond Me a bond NH O a bond T3a OH
    352 N NMe Q1j a bond Me a bond NH O a bond T3b OH
    353 N NMe Q1j a bond Me a bond NH O a bond T3c OH
    354 N NMe Q1j a bond Me a bond NH O a bond T3d OH
    355 N NMe Q1j a bond Me a bond NH O a bond T3e OH
    356 N NMe Q1j a bond Me a bond NH O a bond T3f OH
    357 N NMe Q1j a bond Me a bond NH O a bond T3g OH
    358 N NMe Q1j a bond Me a bond NH O a bond T3h OH
    359 N NMe Q1j a bond Me a bond NH O a bond T3i OH
    360 N NMe Q1j a bond Me a bond NH O a bond T3j OH
    361 N NMe Q1j a bond H a bond NH S NH T3a OH
    362 N NMe Q1j a bond H a bond NH S NH T3b OH
    363 N NMe Q1j a bond H a bond NH S NH T3c OH
    364 N NMe Q1j a bond H a bond NH S NH T3d OH
    365 N NMe Q1j a bond H a bond NH S NH T3e OH
    366 N NMe Q1j a bond H a bond NH S NH T3f OH
    367 N NMe Q1j a bond H a bond NH S NH T3g OH
    368 N NMe Q1j a bond H a bond NH S NH T3h OH
    369 N NMe Q1j a bond H a bond NH S NH T3i OH
    370 N NMe Q1j a bond H a bond NH S NH T3j OH
    371 N NMe Q1j a bond H a bond NH S a bond T3a OH
    372 N NMe Q1j a bond H a bond NH S a bond T3b OH
    373 N NMe Q1j a bond H a bond NH S a bond T3c OH
    374 N NMe Q1j a bond H a bond NH S a bond T3d OH
    375 N NMe Q1j a bond H a bond NH S a bond T3e OH
    376 N NMe Q1j a bond H a bond NH S a bond T3f OH
    377 N NMe Q1j a bond H a bond NH S a bond T3g OH
    378 N NMe Q1j a bond H a bond NH S a bond T3h OH
    379 N NMe Q1j a bond H a bond NH S a bond T3i OH
    380 N NMe Q1j a bond H a bond NH S a bond T3j OH
    381 N NMe Q1j a bond H a bond NH O NH T3a OH
    382 N NMe Q1j a bond H a bond NH O NH T3b OH
    383 N NMe Q1j a bond H a bond NH O NH T3c OH
    384 N NMe Q1j a bond H a bond NH O NH T3d OH
    385 N NMe Q1j a bond H a bond NH O NH T3e OH
    386 N NMe Q1j a bond H a bond NH O NH T3f OH
    387 N NMe Q1j a bond H a bond NH O NH T3g OH
    388 N NMe Q1j a bond H a bond NH O NH T3h OH
    389 N NMe Q1j a bond H a bond NH O NH T3i OH
    390 N NMe Q1j a bond H a bond NH O NH T3j OH
    391 N NMe Q1j a bond H a bond NH O a bond T3a OH
    392 N NMe Q1j a bond H a bond NH O a bond T3b OH
    393 N NMe Q1j a bond H a bond NH O a bond T3c OH
    394 N NMe Q1j a bond H a bond NH O a bond T3d OH
    395 N NMe Q1j a bond H a bond NH O a bond T3e OH
    396 N NMe Q1j a bond H a bond NH O a bond T3f OH
    397 N NMe Q1j a bond H a bond NH O a bond T3g OH
    398 N NMe Q1j a bond H a bond NH O a bond T3h OH
    399 N NMe Q1j a bond H a bond NH O a bond T3i OH
    400 N NMe Q1j a bond H a bond NH O a bond T3j OH
    401 N S Q1a a bond Me a bond NH S NH T3a OH
    402 N S Q1a a bond Me a bond NH S NH T3b OH
    403 N S Q1a a bond Me a bond NH S NH T3c OH
    404 N S Q1a a bond Me a bond NH S NH T3d OH
    405 N S Q1a a bond Me a bond NH S NH T3e OH
    406 N S Q1a a bond Me a bond NH S NH T3f OH
    407 N S Q1a a bond Me a bond NH S NH T3g OH
    408 N S Q1a a bond Me a bond NH S NH T3h OH
    409 N S Q1a a bond Me a bond NH S NH T3i OH
    410 N S Q1a a bond Me a bond NH S NH T3j OH
    411 N S Q1a a bond Me a bond NH S a bond T3a OH
    412 N S Q1a a bond Me a bond NH S a bond T3b OH
    413 N S Q1a a bond Me a bond NH S a bond T3c OH
    414 N S Q1a a bond Me a bond NH S a bond T3d OH
    415 N S Q1a a bond Me a bond NH S a bond T3e OH
    416 N S Q1a a bond Me a bond NH S a bond T3f OH
    417 N S Q1a a bond Me a bond NH S a bond T3g OH
    418 N S Q1a a bond Me a bond NH S a bond T3h OH
    419 N S Q1a a bond Me a bond NH S a bond T3i OH
    420 N S Q1a a bond Me a bond NH S a bond T3j OH
    421 N S Q1a a bond Me a bond NH O NH T3a OH
    422 N S Q1a a bond Me a bond NH O NH T3b OH
    423 N S Q1a a bond Me a bond NH O NH T3c OH
    424 N S Q1a a bond Me a bond NH O NH T3d OH
    425 N S Q1a a bond Me a bond NH O NH T3e OH
    426 N S Q1a a bond Me a bond NH O NH T3f OH
    427 N S Q1a a bond Me a bond NH O NH T3g OH
    428 N S Q1a a bond Me a bond NH O NH T3h OH
    429 N S Q1a a bond Me a bond NH O NH T3i OH
    430 N S Q1a a bond Me a bond NH O NH T3j OH
    431 N S Q1a a bond Me a bond NH O a bond T3a OH
    432 N S Q1a a bond Me a bond NH O a bond T3b OH
    433 N S Q1a a bond Me a bond NH O a bond T3c OH
    434 N S Q1a a bond Me a bond NH O a bond T3d OH
    435 N S Q1a a bond Me a bond NH O a bond T3e OH
    436 N S Q1a a bond Me a bond NH O a bond T3f OH
    437 N S Q1a a bond Me a bond NH O a bond T3g OH
    438 N S Q1a a bond Me a bond NH O a bond T3h OH
    439 N S Q1a a bond Me a bond NH O a bond T3i OH
    440 N S Q1a a bond Me a bond NH O a bond T3j OH
    441 N S Q1a a bond H a bond NH S NH T3a OH
    442 N S Q1a a bond H a bond NH S NH T3b OH
    443 N S Q1a a bond H a bond NH S NH T3c OH
    444 N S Q1a a bond H a bond NH S NH T3d OH
    445 N S Q1a a bond H a bond NH S NH T3e OH
    446 N S Q1a a bond H a bond NH S NH T3f OH
    447 N S Q1a a bond H a bond NH S NH T3g OH
    448 N S Q1a a bond H a bond NH S NH T3h OH
    449 N S Q1a a bond H a bond NH S NH T3i OH
    450 N S Q1a a bond H a bond NH S NH T3j OH
    451 N S Q1a a bond H a bond NH S a bond T3a OH
    452 N S Q1a a bond H a bond NH S a bond T3b OH
    453 N S Q1a a bond H a bond NH S a bond T3c OH
    454 N S Q1a a bond H a bond NH S a bond T3d OH
    455 N S Q1a a bond H a bond NH S a bond T3e OH
    456 N S Q1a a bond H a bond NH S a bond T3f OH
    457 N S Q1a a bond H a bond NH S a bond T3g OH
    458 N S Q1a a bond H a bond NH S a bond T3h OH
    459 N S Q1a a bond H a bond NH S a bond T3i OH
    460 N S Q1a a bond H a bond NH S a bond T3j OH
    461 N S Q1a a bond H a bond NH O NH T3a OH
    462 N S Q1a a bond H a bond NH O NH T3b OH
    463 N S Q1a a bond H a bond NH O NH T3c OH
    464 N S Q1a a bond H a bond NH O NH T3d OH
    465 N S Q1a a bond H a bond NH O NH T3e OH
    466 N S Q1a a bond H a bond NH O NH T3f OH
    467 N S Q1a a bond H a bond NH O NH T3g OH
    468 N S Q1a a bond H a bond NH O NH T3h OH
    469 N S Q1a a bond H a bond NH O NH T3i OH
    470 N S Q1a a bond H a bond NH O NH T3j OH
    471 N S Q1a a bond H a bond NH O a bond T3a OH
    472 N S Q1a a bond H a bond NH O a bond T3b OH
    473 N S Q1a a bond H a bond NH O a bond T3c OH
    474 N S Q1a a bond H a bond NH O a bond T3d OH
    475 N S Q1a a bond H a bond NH O a bond T3e OH
    476 N S Q1a a bond H a bond NH O a bond T3f OH
    477 N S Q1a a bond H a bond NH O a bond T3g OH
    478 N S Q1a a bond H a bond NH O a bond T3h OH
    479 N S Q1a a bond H a bond NH O a bond T3i OH
    480 N S Q1a a bond H a bond NH O a bond T3j OH
    481 N S Q1b a bond Me a bond NH S NH T3a OH
    482 N S Q1b a bond Me a bond NH S NH T3b OH
    483 N S Q1b a bond Me a bond NH S NH T3c OH
    484 N S Q1b a bond Me a bond NH S NH T3d OH
    485 N S Q1b a bond Me a bond NH S NH T3e OH
    486 N S Q1b a bond Me a bond NH S NH T3f OH
    487 N S Q1b a bond Me a bond NH S NH T3g OH
    488 N S Q1b a bond Me a bond NH S NH T3h OH
    489 N S Q1b a bond Me a bond NH S NH T3i OH
    490 N S Q1b a bond Me a bond NH S NH T3j OH
    491 N S Q1b a bond Me a bond NH S a bond T3a OH
    492 N S Q1b a bond Me a bond NH S a bond T3b OH
    493 N S Q1b a bond Me a bond NH S a bond T3c OH
    494 N S Q1b a bond Me a bond NH S a bond T3d OH
    495 N S Q1b a bond Me a bond NH S a bond T3e OH
    496 N S Q1b a bond Me a bond NH S a bond T3f OH
    497 N S Q1b a bond Me a bond NH S a bond T3g OH
    498 N S Q1b a bond Me a bond NH S a bond T3h OH
    499 N S Q1b a bond Me a bond NH S a bond T3i OH
    500 N S Q1b a bond Me a bond NH S a bond T3j OH
    501 N S Q1b a bond Me a bond NH O NH T3a OH
    502 N S Q1b a bond Me a bond NH O NH T3b OH
    503 N S Q1b a bond Me a bond NH O NH T3c OH
    504 N S Q1b a bond Me a bond NH O NH T3d OH
    505 N S Q1b a bond Me a bond NH O NH T3e OH
    506 N S Q1b a bond Me a bond NH O NH T3f OH
    507 N S Q1b a bond Me a bond NH O NH T3g OH
    508 N S Q1b a bond Me a bond NH O NH T3h OH
    509 N S Q1b a bond Me a bond NH O NH T3i OH
    510 N S Q1b a bond Me a bond NH O NH T3j OH
    511 N S Q1b a bond Me a bond NH O a bond T3a OH
    512 N S Q1b a bond Me a bond NH O a bond T3b OH
    513 N S Q1b a bond Me a bond NH O a bond T3c OH
    514 N S Q1b a bond Me a bond NH O a bond T3d OH
    515 N S Q1b a bond Me a bond NH O a bond T3e OH
    516 N S Q1b a bond Me a bond NH O a bond T3f OH
    517 N S Q1b a bond Me a bond NH O a bond T3g OH
    518 N S Q1b a bond Me a bond NH O a bond T3h OH
    519 N S Q1b a bond Me a bond NH O a bond T3i OH
    520 N S Q1b a bond Me a bond NH O a bond T3j OH
    521 N S Q1b a bond H a bond NH S NH T3a OH
    522 N S Q1b a bond H a bond NH S NH T3b OH
    523 N S Q1b a bond H a bond NH S NH T3c OH
    524 N S Q1b a bond H a bond NH S NH T3d OH
    525 N S Q1b a bond H a bond NH S NH T3e OH
    526 N S Q1b a bond H a bond NH S NH T3f OH
    527 N S Q1b a bond H a bond NH S NH T3g OH
    528 N S Q1b a bond H a bond NH S NH T3h OH
    529 N S Q1b a bond H a bond NH S NH T3i OH
    530 N S Q1b a bond H a bond NH S NH T3j OH
    531 N S Q1b a bond H a bond NH S a bond T3a OH
    532 N S Q1b a bond H a bond NH S a bond T3b OH
    533 N S Q1b a bond H a bond NH S a bond T3c OH
    534 N S Q1b a bond H a bond NH S a bond T3d OH
    535 N S Q1b a bond H a bond NH S a bond T3e OH
    536 N S Q1b a bond H a bond NH S a bond T3f OH
    537 N S Q1b a bond H a bond NH S a bond T3g OH
    538 N S Q1b a bond H a bond NH S a bond T3h OH
    539 N S Q1b a bond H a bond NH S a bond T3i OH
    540 N S Q1b a bond H a bond NH S a bond T3j OH
    541 N S Q1b a bond H a bond NH O NH T3a OH
    542 N S Q1b a bond H a bond NH O NH T3b OH
    543 N S Q1b a bond H a bond NH O NH T3c OH
    544 N S Q1b a bond H a bond NH O NH T3d OH
    545 N S Q1b a bond H a bond NH O NH T3e OH
    546 N S Q1b a bond H a bond NH O NH T3f OH
    547 N S Q1b a bond H a bond NH O NH T3g OH
    548 N S Q1b a bond H a bond NH O NH T3h OH
    549 N S Q1b a bond H a bond NH O NH T3i OH
    550 N S Q1b a bond H a bond NH O NH T3j OH
    551 N S Q1b a bond H a bond NH O a bond T3a OH
    552 N S Q1b a bond H a bond NH O a bond T3b OH
    553 N S Q1b a bond H a bond NH O a bond T3c OH
    554 N S Q1b a bond H a bond NH O a bond T3d OH
    555 N S Q1b a bond H a bond NH O a bond T3e OH
    556 N S Q1b a bond H a bond NH O a bond T3f OH
    557 N S Q1b a bond H a bond NH O a bond T3g OH
    558 N S Q1b a bond H a bond NH O a bond T3h OH
    559 N S Q1b a bond H a bond NH O a bond T3i OH
    560 N S Q1b a bond H a bond NH O a bond T3j OH
    561 N S Q1c a bond Me a bond NH S NH T3a OH
    562 N S Q1c a bond Me a bond NH S NH T3b OH
    563 N S Q1c a bond Me a bond NH S NH T3c OH
    564 N S Q1c a bond Me a bond NH S NH T3d OH
    565 N S Q1c a bond Me a bond NH S NH T3e OH
    566 N S Q1c a bond Me a bond NH S NH T3f OH
    567 N S Q1c a bond Me a bond NH S NH T3g OH
    568 N S Q1c a bond Me a bond NH S NH T3h OH
    569 N S Q1c a bond Me a bond NH S NH T3i OH
    570 N S Q1c a bond Me a bond NH S NH T3j OH
    571 N S Q1c a bond Me a bond NH S a bond T3a OH
    572 N S Q1c a bond Me a bond NH S a bond T3b OH
    573 N S Q1c a bond Me a bond NH S a bond T3c OH
    574 N S Q1c a bond Me a bond NH S a bond T3d OH
    575 N S Q1c a bond Me a bond NH S a bond T3e OH
    576 N S Q1c a bond Me a bond NH S a bond T3f OH
    577 N S Q1c a bond Me a bond NH S a bond T3g OH
    578 N S Q1c a bond Me a bond NH S a bond T3h OH
    579 N S Q1c a bond Me a bond NH S a bond T3i OH
    580 N S Q1c a bond Me a bond NH S a bond T3j OH
    581 N S Q1c a bond Me a bond NH O NH T3a OH
    582 N S Q1c a bond Me a bond NH O NH T3b OH
    583 N S Q1c a bond Me a bond NH O NH T3c OH
    584 N S Q1c a bond Me a bond NH O NH T3d OH
    585 N S Q1c a bond Me a bond NH O NH T3e OH
    586 N S Q1c a bond Me a bond NH O NH T3f OH
    587 N S Q1c a bond Me a bond NH O NH T3g OH
    588 N S Q1c a bond Me a bond NH O NH T3h OH
    589 N S Q1c a bond Me a bond NH O NH T3i OH
    590 N S Q1c a bond Me a bond NH O NH T3j OH
    591 N S Q1c a bond Me a bond NH O a bond T3a OH
    592 N S Q1c a bond Me a bond NH O a bond T3b OH
    593 N S Q1c a bond Me a bond NH O a bond T3c OH
    594 N S Q1c a bond Me a bond NH O a bond T3d OH
    595 N S Q1c a bond Me a bond NH O a bond T3e OH
    596 N S Q1c a bond Me a bond NH O a bond T3f OH
    597 N S Q1c a bond Me a bond NH O a bond T3g OH
    598 N S Q1c a bond Me a bond NH O a bond T3h OH
    599 N S Q1c a bond Me a bond NH O a bond T3i OH
    600 N S Q1c a bond Me a bond NH O a bond T3j OH
    601 N S Q1c a bond H a bond NH S NH T3a OH
    602 N S Q1c a bond H a bond NH S NH T3b OH
    603 N S Q1c a bond H a bond NH S NH T3c OH
    604 N S Q1c a bond H a bond NH S NH T3d OH
    605 N S Q1c a bond H a bond NH S NH T3e OH
    606 N S Q1c a bond H a bond NH S NH T3f OH
    607 N S Q1c a bond H a bond NH S NH T3g OH
    608 N S Q1c a bond H a bond NH S NH T3h OH
    609 N S Q1c a bond H a bond NH S NH T3i OH
    610 N S Q1c a bond H a bond NH S NH T3j OH
    611 N S Q1c a bond H a bond NH S a bond T3a OH
    612 N S Q1c a bond H a bond NH S a bond T3b OH
    613 N S Q1c a bond H a bond NH S a bond T3c OH
    614 N S Q1c a bond H a bond NH S a bond T3d OH
    615 N S Q1c a bond H a bond NH S a bond T3e OH
    616 N S Q1c a bond H a bond NH S a bond T3f OH
    617 N S Q1c a bond H a bond NH S a bond T3g OH
    618 N S Q1c a bond H a bond NH S a bond T3h OH
    619 N S Q1c a bond H a bond NH S a bond T3i OH
    620 N S Q1c a bond H a bond NH S a bond T3j OH
    621 N S Q1c a bond H a bond NH O NH T3a OH
    622 N S Q1c a bond H a bond NH O NH T3b OH
    623 N S Q1c a bond H a bond NH O NH T3c OH
    624 N S Q1c a bond H a bond NH O NH T3d OH
    625 N S Q1c a bond H a bond NH O NH T3e OH
    626 N S Q1c a bond H a bond NH O NH T3f OH
    627 N S Q1c a bond H a bond NH O NH T3g OH
    628 N S Q1c a bond H a bond NH O NH T3h OH
    629 N S Q1c a bond H a bond NH O NH T3i OH
    630 N S Q1c a bond H a bond NH O NH T3j OH
    631 N S Q1c a bond H a bond NH O a bond T3a OH
    632 N S Q1c a bond H a bond NH O a bond T3b OH
    633 N S Q1c a bond H a bond NH O a bond T3c OH
    634 N S Q1c a bond H a bond NH O a bond T3d OH
    635 N S Q1c a bond H a bond NH O a bond T3e OH
    636 N S Q1c a bond H a bond NH O a bond T3f OH
    637 N S Q1c a bond H a bond NH O a bond T3g OH
    638 N S Q1c a bond H a bond NH O a bond T3h OH
    639 N S Q1c a bond H a bond NH O a bond T3i OH
    640 N S Q1c a bond H a bond NH O a bond T3j OH
    641 N S Q1i a bond Me a bond NH S NH T3a OH
    642 N S Q1i a bond Me a bond NH S NH T3b OH
    643 N S Q1i a bond Me a bond NH S NH T3c OH
    644 N S Q1i a bond Me a bond NH S NH T3d OH
    645 N S Q1i a bond Me a bond NH S NH T3e OH
    646 N S Q1i a bond Me a bond NH S NH T3f OH
    647 N S Q1i a bond Me a bond NH S NH T3g OH
    648 N S Q1i a bond Me a bond NH S NH T3h OH
    649 N S Q1i a bond Me a bond NH S NH T3i OH
    650 N S Q1i a bond Me a bond NH S NH T3j OH
    651 N S Q1i a bond Me a bond NH S a bond T3a OH
    652 N S Q1i a bond Me a bond NH S a bond T3b OH
    653 N S Q1i a bond Me a bond NH S a bond T3c OH
    654 N S Q1i a bond Me a bond NH S a bond T3d OH
    655 N S Q1i a bond Me a bond NH S a bond T3e OH
    656 N S Q1i a bond Me a bond NH S a bond T3f OH
    657 N S Q1i a bond Me a bond NH S a bond T3g OH
    658 N S Q1i a bond Me a bond NH S a bond T3h OH
    659 N S Q1i a bond Me a bond NH S a bond T3i OH
    660 N S Q1i a bond Me a bond NH S a bond T3j OH
    661 N S Q1i a bond Me a bond NH O NH T3a OH
    662 N S Q1i a bond Me a bond NH O NH T3b OH
    663 N S Q1i a bond Me a bond NH O NH T3c OH
    664 N S Q1i a bond Me a bond NH O NH T3d OH
    665 N S Q1i a bond Me a bond NH O NH T3e OH
    666 N S Q1i a bond Me a bond NH O NH T3f OH
    667 N S Q1i a bond Me a bond NH O NH T3g OH
    668 N S Q1i a bond Me a bond NH O NH T3h OH
    669 N S Q1i a bond Me a bond NH O NH T3i OH
    670 N S Q1i a bond Me a bond NH O NH T3j OH
    671 N S Q1i a bond Me a bond NH O a bond T3a OH
    672 N S Q1i a bond Me a bond NH O a bond T3b OH
    673 N S Q1i a bond Me a bond NH O a bond T3c OH
    674 N S Q1i a bond Me a bond NH O a bond T3d OH
    675 N S Q1i a bond Me a bond NH O a bond T3e OH
    676 N S Q1i a bond Me a bond NH O a bond T3f OH
    677 N S Q1i a bond Me a bond NH O a bond T3g OH
    678 N S Q1i a bond Me a bond NH O a bond T3h OH
    679 N S Q1i a bond Me a bond NH O a bond T3i OH
    680 N S Q1i a bond Me a bond NH O a bond T3j OH
    681 N S Q1i a bond H a bond NH S NH T3a OH
    682 N S Q1i a bond H a bond NH S NH T3b OH
    683 N S Q1i a bond H a bond NH S NH T3c OH
    684 N S Q1i a bond H a bond NH S NH T3d OH
    685 N S Q1i a bond H a bond NH S NH T3e OH
    686 N S Q1i a bond H a bond NH S NH T3f OH
    687 N S Q1i a bond H a bond NH S NH T3g OH
    688 N S Q1i a bond H a bond NH S NH T3h OH
    689 N S Q1i a bond H a bond NH S NH T3i OH
    690 N S Q1i a bond H a bond NH S NH T3j OH
    691 N S Q1i a bond H a bond NH S a bond T3a OH
    692 N S Q1i a bond H a bond NH S a bond T3b OH
    693 N S Q1i a bond H a bond NH S a bond T3c OH
    694 N S Q1i a bond H a bond NH S a bond T3d OH
    695 N S Q1i a bond H a bond NH S a bond T3e OH
    696 N S Q1i a bond H a bond NH S a bond T3f OH
    697 N S Q1i a bond H a bond NH S a bond T3g OH
    698 N S Q1i a bond H a bond NH S a bond T3h OH
    699 N S Q1i a bond H a bond NH S a bond T3i OH
    700 N S Q1i a bond H a bond NH S a bond T3j OH
    701 N S Q1i a bond H a bond NH O NH T3a OH
    702 N S Q1i a bond H a bond NH O NH T3b OH
    703 N S Q1i a bond H a bond NH O NH T3c OH
    704 N S Q1i a bond H a bond NH O NH T3d OH
    705 N S Q1i a bond H a bond NH O NH T3e OH
    706 N S Q1i a bond H a bond NH O NH T3f OH
    707 N S Q1i a bond H a bond NH O NH T3g OH
    708 N S Q1i a bond H a bond NH O NH T3h OH
    709 N S Q1i a bond H a bond NH O NH T3i OH
    710 N S Q1i a bond H a bond NH O NH T3j OH
    711 N S Q1i a bond H a bond NH O a bond T3a OH
    712 N S Q1i a bond H a bond NH O a bond T3b OH
    713 N S Q1i a bond H a bond NH O a bond T3c OH
    714 N S Q1i a bond H a bond NH O a bond T3d OH
    715 N S Q1i a bond H a bond NH O a bond T3e OH
    716 N S Q1i a bond H a bond NH O a bond T3f OH
    717 N S Q1i a bond H a bond NH O a bond T3g OH
    718 N S Q1i a bond H a bond NH O a bond T3h OH
    719 N S Q1i a bond H a bond NH O a bond T3i OH
    720 N S Q1i a bond H a bond NH O a bond T3j OH
    721 N S Q1j a bond Me a bond NH S NH T3a OH
    722 N S Q1j a bond Me a bond NH S NH T3b OH
    723 N S Q1j a bond Me a bond NH S NH T3c OH
    724 N S Q1j a bond Me a bond NH S NH T3d OH
    725 N S Q1j a bond Me a bond NH S NH T3e OH
    726 N S Q1j a bond Me a bond NH S NH T3f OH
    727 N S Q1j a bond Me a bond NH S NH T3g OH
    728 N S Q1j a bond Me a bond NH S NH T3h OH
    729 N S Q1j a bond Me a bond NH S NH T3i OH
    730 N S Q1j a bond Me a bond NH S NH T3j OH
    731 N S Q1j a bond Me a bond NH S a bond T3a OH
    732 N S Q1j a bond Me a bond NH S a bond T3b OH
    733 N S Q1j a bond Me a bond NH S a bond T3c OH
    734 N S Q1j a bond Me a bond NH S a bond T3d OH
    735 N S Q1j a bond Me a bond NH S a bond T3e OH
    736 N S Q1j a bond Me a bond NH S a bond T3f OH
    737 N S Q1j a bond Me a bond NH S a bond T3g OH
    738 N S Q1j a bond Me a bond NH S a bond T3h OH
    739 N S Q1j a bond Me a bond NH S a bond T3i OH
    740 N S Q1j a bond Me a bond NH S a bond T3j OH
    741 N S Q1j a bond Me a bond NH O NH T3a OH
    742 N S Q1j a bond Me a bond NH O NH T3b OH
    743 N S Q1j a bond Me a bond NH O NH T3c OH
    744 N S Q1j a bond Me a bond NH O NH T3d OH
    745 N S Q1j a bond Me a bond NH O NH T3e OH
    746 N S Q1j a bond Me a bond NH O NH T3f OH
    747 N S Q1j a bond Me a bond NH O NH T3g OH
    748 N S Q1j a bond Me a bond NH O NH T3h OH
    749 N S Q1j a bond Me a bond NH O NH T3i OH
    750 N S Q1j a bond Me a bond NH O NH T3j OH
    751 N S Q1j a bond Me a bond NH O a bond T3a OH
    752 N S Q1j a bond Me a bond NH O a bond T3b OH
    753 N S Q1j a bond Me a bond NH O a bond T3c OH
    754 N S Q1j a bond Me a bond NH O a bond T3d OH
    755 N S Q1j a bond Me a bond NH O a bond T3e OH
    756 N S Q1j a bond Me a bond NH O a bond T3f OH
    757 N S Q1j a bond Me a bond NH O a bond T3g OH
    758 N S Q1j a bond Me a bond NH O a bond T3h OH
    759 N S Q1j a bond Me a bond NH O a bond T3i OH
    760 N S Q1j a bond Me a bond NH O a bond T3j OH
    761 N S Q1j a bond H a bond NH S NH T3a OH
    762 N S Q1j a bond H a bond NH S NH T3b OH
    763 N S Q1j a bond H a bond NH S NH T3c OH
    764 N S Q1j a bond H a bond NH S NH T3d OH
    765 N S Q1j a bond H a bond NH S NH T3e OH
    766 N S Q1j a bond H a bond NH S NH T3f OH
    767 N S Q1j a bond H a bond NH S NH T3g OH
    768 N S Q1j a bond H a bond NH S NH T3h OH
    769 N S Q1j a bond H a bond NH S NH T3i OH
    770 N S Q1j a bond H a bond NH S NH T3j OH
    771 N S Q1j a bond H a bond NH S a bond T3a OH
    772 N S Q1j a bond H a bond NH S a bond T3b OH
    773 N S Q1j a bond H a bond NH S a bond T3c OH
    774 N S Q1j a bond H a bond NH S a bond T3d OH
    775 N S Q1j a bond H a bond NH S a bond T3e OH
    776 N S Q1j a bond H a bond NH S a bond T3f OH
    777 N S Q1j a bond H a bond NH S a bond T3g OH
    778 N S Q1j a bond H a bond NH S a bond T3h OH
    779 N S Q1j a bond H a bond NH S a bond T3i OH
    780 N S Q1j a bond H a bond NH S a bond T3j OH
    781 N S Q1j a bond H a bond NH O NH T3a OH
    782 N S Q1j a bond H a bond NH O NH T3b OH
    783 N S Q1j a bond H a bond NH O NH T3c OH
    784 N S Q1j a bond H a bond NH O NH T3d OH
    785 N S Q1j a bond H a bond NH O NH T3e OH
    786 N S Q1j a bond H a bond NH O NH T3f OH
    787 N S Q1j a bond H a bond NH O NH T3g OH
    788 N S Q1j a bond H a bond NH O NH T3h OH
    789 N S Q1j a bond H a bond NH O NH T3i OH
    790 N S Q1j a bond H a bond NH O NH T3j OH
    791 N S Q1j a bond H a bond NH O a bond T3a OH
    792 N S Q1j a bond H a bond NH O a bond T3b OH
    793 N S Q1j a bond H a bond NH O a bond T3c OH
    794 N S Q1j a bond H a bond NH O a bond T3d OH
    795 N S Q1j a bond H a bond NH O a bond T3e OH
    796 N S Q1j a bond H a bond NH O a bond T3f OH
    797 N S Q1j a bond H a bond NH O a bond T3g OH
    798 N S Q1j a bond H a bond NH O a bond T3h OH
    799 N S Q1j a bond H a bond NH O a bond T3i OH
    800 N S Q1j a bond H a bond NH O a bond T3j OH
    801 N O Q1a a bond Me a bond NH S NH T3a OH
    802 N O Q1a a bond Me a bond NH S NH T3b OH
    803 N O Q1a a bond Me a bond NH S NH T3c OH
    804 N O Q1a a bond Me a bond NH S NH T3d OH
    805 N O Q1a a bond Me a bond NH S NH T3e OH
    806 N O Q1a a bond Me a bond NH S NH T3f OH
    807 N O Q1a a bond Me a bond NH S NH T3g OH
    808 N O Q1a a bond Me a bond NH S NH T3h OH
    809 N O Q1a a bond Me a bond NH S NH T3i OH
    810 N O Q1a a bond Me a bond NH S NH T3j OH
    811 N O Q1a a bond Me a bond NH S a bond T3a OH
    812 N O Q1a a bond Me a bond NH S a bond T3b OH
    813 N O Q1a a bond Me a bond NH S a bond T3c OH
    814 N O Q1a a bond Me a bond NH S a bond T3d OH
    815 N O Q1a a bond Me a bond NH S a bond T3e OH
    816 N O Q1a a bond Me a bond NH S a bond T3f OH
    817 N O Q1a a bond Me a bond NH S a bond T3g OH
    818 N O Q1a a bond Me a bond NH S a bond T3h OH
    819 N O Q1a a bond Me a bond NH S a bond T3i OH
    820 N O Q1a a bond Me a bond NH S a bond T3j OH
    821 N O Q1a a bond Me a bond NH O NH T3a OH
    822 N O Q1a a bond Me a bond NH O NH T3b OH
    823 N O Q1a a bond Me a bond NH O NH T3c OH
    824 N O Q1a a bond Me a bond NH O NH T3d OH
    825 N O Q1a a bond Me a bond NH O NH T3e OH
    826 N O Q1a a bond Me a bond NH O NH T3f OH
    827 N O Q1a a bond Me a bond NH O NH T3g OH
    828 N O Q1a a bond Me a bond NH O NH T3h OH
    829 N O Q1a a bond Me a bond NH O NH T3i OH
    830 N O Q1a a bond Me a bond NH O NH T3j OH
    831 N O Q1a a bond Me a bond NH O a bond T3a OH
    832 N O Q1a a bond Me a bond NH O a bond T3b OH
    833 N O Q1a a bond Me a bond NH O a bond T3c OH
    834 N O Q1a a bond Me a bond NH O a bond T3d OH
    835 N O Q1a a bond Me a bond NH O a bond T3e OH
    836 N O Q1a a bond Me a bond NH O a bond T3f OH
    837 N O Q1a a bond Me a bond NH O a bond T3g OH
    838 N O Q1a a bond Me a bond NH O a bond T3h OH
    839 N O Q1a a bond Me a bond NH O a bond T3i OH
    840 N O Q1a a bond Me a bond NH O a bond T3j OH
    841 N O Q1a a bond H a bond NH S NH T3a OH
    842 N O Q1a a bond H a bond NH S NH T3b OH
    843 N O Q1a a bond H a bond NH S NH T3c OH
    844 N O Q1a a bond H a bond NH S NH T3d OH
    845 N O Q1a a bond H a bond NH S NH T3e OH
    846 N O Q1a a bond H a bond NH S NH T3f OH
    847 N O Q1a a bond H a bond NH S NH T3g OH
    848 N O Q1a a bond H a bond NH S NH T3h OH
    849 N O Q1a a bond H a bond NH S NH T3i OH
    850 N O Q1a a bond H a bond NH S NH T3j OH
    851 N O Q1a a bond H a bond NH S a bond T3a OH
    852 N O Q1a a bond H a bond NH S a bond T3b OH
    853 N O Q1a a bond H a bond NH S a bond T3c OH
    854 N O Q1a a bond H a bond NH S a bond T3d OH
    855 N O Q1a a bond H a bond NH S a bond T3e OH
    856 N O Q1a a bond H a bond NH S a bond T3f OH
    857 N O Q1a a bond H a bond NH S a bond T3g OH
    858 N O Q1a a bond H a bond NH S a bond T3h OH
    859 N O Q1a a bond H a bond NH S a bond T3i OH
    860 N O Q1a a bond H a bond NH S a bond T3j OH
    861 N O Q1a a bond H a bond NH O NH T3a OH
    862 N O Q1a a bond H a bond NH O NH T3b OH
    863 N O Q1a a bond H a bond NH O NH T3c OH
    864 N O Q1a a bond H a bond NH O NH T3d OH
    865 N O Q1a a bond H a bond NH O NH T3e OH
    866 N O Q1a a bond H a bond NH O NH T3f OH
    867 N O Q1a a bond H a bond NH O NH T3g OH
    868 N O Q1a a bond H a bond NH O NH T3h OH
    869 N O Q1a a bond H a bond NH O NH T3i OH
    870 N O Q1a a bond H a bond NH O NH T3j OH
    871 N O Q1a a bond H a bond NH O a bond T3a OH
    872 N O Q1a a bond H a bond NH O a bond T3b OH
    873 N O Q1a a bond H a bond NH O a bond T3c OH
    874 N O Q1a a bond H a bond NH O a bond T3d OH
    875 N O Q1a a bond H a bond NH O a bond T3e OH
    876 N O Q1a a bond H a bond NH O a bond T3f OH
    877 N O Q1a a bond H a bond NH O a bond T3g OH
    878 N O Q1a a bond H a bond NH O a bond T3h OH
    879 N O Q1a a bond H a bond NH O a bond T3i OH
    880 N O Q1a a bond H a bond NH O a bond T3j OH
    881 N O Q1b a bond Me a bond NH S NH T3a OH
    882 N O Q1b a bond Me a bond NH S NH T3b OH
    883 N O Q1b a bond Me a bond NH S NH T3c OH
    884 N O Q1b a bond Me a bond NH S NH T3d OH
    885 N O Q1b a bond Me a bond NH S NH T3e OH
    886 N O Q1b a bond Me a bond NH S NH T3f OH
    887 N O Q1b a bond Me a bond NH S NH T3g OH
    888 N O Q1b a bond Me a bond NH S NH T3h OH
    889 N O Q1b a bond Me a bond NH S NH T3i OH
    890 N O Q1b a bond Me a bond NH S NH T3j OH
    891 N O Q1b a bond Me a bond NH S a bond T3a OH
    892 N O Q1b a bond Me a bond NH S a bond T3b OH
    893 N O Q1b a bond Me a bond NH S a bond T3c OH
    894 N O Q1b a bond Me a bond NH S a bond T3d OH
    895 N O Q1b a bond Me a bond NH S a bond T3e OH
    896 N O Q1b a bond Me a bond NH S a bond T3f OH
    897 N O Q1b a bond Me a bond NH S a bond T3g OH
    898 N O Q1b a bond Me a bond NH S a bond T3h OH
    899 N O Q1b a bond Me a bond NH S a bond T3i OH
    900 N O Q1b a bond Me a bond NH S a bond T3j OH
    901 N O Q1b a bond Me a bond NH O NH T3a OH
    902 N O Q1b a bond Me a bond NH O NH T3b OH
    903 N O Q1b a bond Me a bond NH O NH T3c OH
    904 N O Q1b a bond Me a bond NH O NH T3d OH
    905 N O Q1b a bond Me a bond NH O NH T3e OH
    906 N O Q1b a bond Me a bond NH O NH T3f OH
    907 N O Q1b a bond Me a bond NH O NH T3g OH
    908 N O Q1b a bond Me a bond NH O NH T3h OH
    909 N O Q1b a bond Me a bond NH O NH T3i OH
    910 N O Q1b a bond Me a bond NH O NH T3j OH
    911 N O Q1b a bond Me a bond NH O a bond T3a OH
    912 N O Q1b a bond Me a bond NH O a bond T3b OH
    913 N O Q1b a bond Me a bond NH O a bond T3c OH
    914 N O Q1b a bond Me a bond NH O a bond T3d OH
    915 N O Q1b a bond Me a bond NH O a bond T3e OH
    916 N O Q1b a bond Me a bond NH O a bond T3f OH
    917 N O Q1b a bond Me a bond NH O a bond T3g OH
    918 N O Q1b a bond Me a bond NH O a bond T3h OH
    919 N O Q1b a bond Me a bond NH O a bond T3i OH
    920 N O Q1b a bond Me a bond NH O a bond T3j OH
    921 N O Q1b a bond H a bond NH S NH T3a OH
    922 N O Q1b a bond H a bond NH S NH T3b OH
    923 N O Q1b a bond H a bond NH S NH T3c OH
    924 N O Q1b a bond H a bond NH S NH T3d OH
    925 N O Q1b a bond H a bond NH S NH T3e OH
    926 N O Q1b a bond H a bond NH S NH T3f OH
    927 N O Q1b a bond H a bond NH S NH T3g OH
    928 N O Q1b a bond H a bond NH S NH T3h OH
    929 N O Q1b a bond H a bond NH S NH T3i OH
    930 N O Q1b a bond H a bond NH S NH T3j OH
    931 N O Q1b a bond H a bond NH S a bond T3a OH
    932 N O Q1b a bond H a bond NH S a bond T3b OH
    933 N O Q1b a bond H a bond NH S a bond T3c OH
    934 N O Q1b a bond H a bond NH S a bond T3d OH
    935 N O Q1b a bond H a bond NH S a bond T3e OH
    936 N O Q1b a bond H a bond NH S a bond T3f OH
    937 N O Q1b a bond H a bond NH S a bond T3g OH
    938 N O Q1b a bond H a bond NH S a bond T3h OH
    939 N O Q1b a bond H a bond NH S a bond T3i OH
    940 N O Q1b a bond H a bond NH S a bond T3j OH
    941 N O Q1b a bond H a bond NH O NH T3a OH
    942 N O Q1b a bond H a bond NH O NH T3b OH
    943 N O Q1b a bond H a bond NH O NH T3c OH
    944 N O Q1b a bond H a bond NH O NH T3d OH
    945 N O Q1b a bond H a bond NH O NH T3e OH
    946 N O Q1b a bond H a bond NH O NH T3f OH
    947 N O Q1b a bond H a bond NH O NH T3g OH
    948 N O Q1b a bond H a bond NH O NH T3h OH
    949 N O Q1b a bond H a bond NH O NH T3i OH
    950 N O Q1b a bond H a bond NH O NH T3j OH
    951 N O Q1b a bond H a bond NH O a bond T3a OH
    952 N O Q1b a bond H a bond NH O a bond T3b OH
    953 N O Q1b a bond H a bond NH O a bond T3c OH
    954 N O Q1b a bond H a bond NH O a bond T3d OH
    955 N O Q1b a bond H a bond NH O a bond T3e OH
    956 N O Q1b a bond H a bond NH O a bond T3f OH
    957 N O Q1b a bond H a bond NH O a bond T3g OH
    958 N O Q1b a bond H a bond NH O a bond T3h OH
    959 N O Q1b a bond H a bond NH O a bond T3i OH
    960 N O Q1b a bond H a bond NH O a bond T3j OH
    961 N O Q1c a bond Me a bond NH S NH T3a OH
    962 N O Q1c a bond Me a bond NH S NH T3b OH
    963 N O Q1c a bond Me a bond NH S NH T3c OH
    964 N O Q1c a bond Me a bond NH S NH T3d OH
    965 N O Q1c a bond Me a bond NH S NH T3e OH
    966 N O Q1c a bond Me a bond NH S NH T3f OH
    967 N O Q1c a bond Me a bond NH S NH T3g OH
    968 N O Q1c a bond Me a bond NH S NH T3h OH
    969 N O Q1c a bond Me a bond NH S NH T3i OH
    970 N O Q1c a bond Me a bond NH S NH T3j OH
    971 N O Q1c a bond Me a bond NH S a bond T3a OH
    972 N O Q1c a bond Me a bond NH S a bond T3b OH
    973 N O Q1c a bond Me a bond NH S a bond T3c OH
    974 N O Q1c a bond Me a bond NH S a bond T3d OH
    975 N O Q1c a bond Me a bond NH S a bond T3e OH
    976 N O Q1c a bond Me a bond NH S a bond T3f OH
    977 N O Q1c a bond Me a bond NH S a bond T3g OH
    978 N O Q1c a bond Me a bond NH S a bond T3h OH
    979 N O Q1c a bond Me a bond NH S a bond T3i OH
    980 N O Q1c a bond Me a bond NH S a bond T3j OH
    981 N O Q1c a bond Me a bond NH O NH T3a OH
    982 N O Q1c a bond Me a bond NH O NH T3b OH
    983 N O Q1c a bond Me a bond NH O NH T3c OH
    984 N O Q1c a bond Me a bond NH O NH T3d OH
    985 N O Q1c a bond Me a bond NH O NH T3e OH
    986 N O Q1c a bond Me a bond NH O NH T3f OH
    987 N O Q1c a bond Me a bond NH O NH T3g OH
    988 N O Q1c a bond Me a bond NH O NH T3h OH
    989 N O Q1c a bond Me a bond NH O NH T3i OH
    990 N O Q1c a bond Me a bond NH O NH T3j OH
    991 N O Q1c a bond Me a bond NH O a bond T3a OH
    992 N O Q1c a bond Me a bond NH O a bond T3b OH
    993 N O Q1c a bond Me a bond NH O a bond T3c OH
    994 N O Q1c a bond Me a bond NH O a bond T3d OH
    995 N O Q1c a bond Me a bond NH O a bond T3e OH
    996 N O Q1c a bond Me a bond NH O a bond T3f OH
    997 N O Q1c a bond Me a bond NH O a bond T3g OH
    998 N O Q1c a bond Me a bond NH O a bond T3h OH
    999 N O Q1c a bond Me a bond NH O a bond T3i OH
    1000 N O Q1c a bond Me a bond NH O a bond T3j OH
    1001 N O Q1c a bond H a bond NH S NH T3a OH
    1002 N O Q1c a bond H a bond NH S NH T3b OH
    1003 N O Q1c a bond H a bond NH S NH T3c OH
    1004 N O Q1c a bond H a bond NH S NH T3d OH
    1005 N O Q1c a bond H a bond NH S NH T3e OH
    1006 N O Q1c a bond H a bond NH S NH T3f OH
    1007 N O Q1c a bond H a bond NH S NH T3g OH
    1008 N O Q1c a bond H a bond NH S NH T3h OH
    1009 N O Q1c a bond H a bond NH S NH T3i OH
    1010 N O Q1c a bond H a bond NH S NH T3j OH
    1011 N O Q1c a bond H a bond NH S a bond T3a OH
    1012 N O Q1c a bond H a bond NH S a bond T3b OH
    1013 N O Q1c a bond H a bond NH S a bond T3c OH
    1014 N O Q1c a bond H a bond NH S a bond T3d OH
    1015 N O Q1c a bond H a bond NH S a bond T3e OH
    1016 N O Q1c a bond H a bond NH S a bond T3f OH
    1017 N O Q1c a bond H a bond NH S a bond T3g OH
    1018 N O Q1c a bond H a bond NH S a bond T3h OH
    1019 N O Q1c a bond H a bond NH S a bond T3i OH
    1020 N O Q1c a bond H a bond NH S a bond T3j OH
    1021 N O Q1c a bond H a bond NH O NH T3a OH
    1022 N O Q1c a bond H a bond NH O NH T3b OH
    1023 N O Q1c a bond H a bond NH O NH T3c OH
    1024 N O Q1c a bond H a bond NH O NH T3d OH
    1025 N O Q1c a bond H a bond NH O NH T3e OH
    1026 N O Q1c a bond H a bond NH O NH T3f OH
    1027 N O Q1c a bond H a bond NH O NH T3g OH
    1028 N O Q1c a bond H a bond NH O NH T3h OH
    1029 N O Q1c a bond H a bond NH O NH T3i OH
    1030 N O Q1c a bond H a bond NH O NH T3j OH
    1031 N O Q1c a bond H a bond NH O a bond T3a OH
    1032 N O Q1c a bond H a bond NH O a bond T3b OH
    1033 N O Q1c a bond H a bond NH O a bond T3c OH
    1034 N O Q1c a bond H a bond NH O a bond T3d OH
    1035 N O Q1c a bond H a bond NH O a bond T3e OH
    1036 N O Q1c a bond H a bond NH O a bond T3f OH
    1037 N O Q1c a bond H a bond NH O a bond T3g OH
    1038 N O Q1c a bond H a bond NH O a bond T3h OH
    1039 N O Q1c a bond H a bond NH O a bond T3i OH
    1040 N O Q1c a bond H a bond NH O a bond T3j OH
    1041 N O Q1i a bond Me a bond NH S NH T3a OH
    1042 N O Q1i a bond Me a bond NH S NH T3b OH
    1043 N O Q1i a bond Me a bond NH S NH T3c OH
    1044 N O Q1i a bond Me a bond NH S NH T3d OH
    1045 N O Q1i a bond Me a bond NH S NH T3e OH
    1046 N O Q1i a bond Me a bond NH S NH T3f OH
    1047 N O Q1i a bond Me a bond NH S NH T3g OH
    1048 N O Q1i a bond Me a bond NH S NH T3h OH
    1049 N O Q1i a bond Me a bond NH S NH T3i OH
    1050 N O Q1i a bond Me a bond NH S NH T3j OH
    1051 N O Q1i a bond Me a bond NH S a bond T3a OH
    1052 N O Q1i a bond Me a bond NH S a bond T3b OH
    1053 N O Q1i a bond Me a bond NH S a bond T3c OH
    1054 N O Q1i a bond Me a bond NH S a bond T3d OH
    1055 N O Q1i a bond Me a bond NH S a bond T3e OH
    1056 N O Q1i a bond Me a bond NH S a bond T3f OH
    1057 N O Q1i a bond Me a bond NH S a bond T3g OH
    1058 N O Q1i a bond Me a bond NH S a bond T3h OH
    1059 N O Q1i a bond Me a bond NH S a bond T3i OH
    1060 N O Q1i a bond Me a bond NH S a bond T3j OH
    1061 N O Q1i a bond Me a bond NH O NH T3a OH
    1062 N O Q1i a bond Me a bond NH O NH T3b OH
    1063 N O Q1i a bond Me a bond NH O NH T3c OH
    1064 N O Q1i a bond Me a bond NH O NH T3d OH
    1065 N O Q1i a bond Me a bond NH O NH T3e OH
    1066 N O Q1i a bond Me a bond NH O NH T3f OH
    1067 N O Q1i a bond Me a bond NH O NH T3g OH
    1068 N O Q1i a bond Me a bond NH O NH T3h OH
    1069 N O Q1i a bond Me a bond NH O NH T3i OH
    1070 N O Q1i a bond Me a bond NH O NH T3j OH
    1071 N O Q1i a bond Me a bond NH O a bond T3a OH
    1072 N O Q1i a bond Me a bond NH O a bond T3b OH
    1073 N O Q1i a bond Me a bond NH O a bond T3c OH
    1074 N O Q1i a bond Me a bond NH O a bond T3d OH
    1075 N O Q1i a bond Me a bond NH O a bond T3e OH
    1076 N O Q1i a bond Me a bond NH O a bond T3f OH
    1077 N O Q1i a bond Me a bond NH O a bond T3g OH
    1078 N O Q1i a bond Me a bond NH O a bond T3h OH
    1079 N O Q1i a bond Me a bond NH O a bond T3i OH
    1080 N O Q1i a bond Me a bond NH O a bond T3j OH
    1081 N O Q1i a bond H a bond NH S NH T3a OH
    1082 N O Q1i a bond H a bond NH S NH T3b OH
    1083 N O Q1i a bond H a bond NH S NH T3c OH
    1084 N O Q1i a bond H a bond NH S NH T3d OH
    1085 N O Q1i a bond H a bond NH S NH T3e OH
    1086 N O Q1i a bond H a bond NH S NH T3f OH
    1087 N O Q1i a bond H a bond NH S NH T3g OH
    1088 N O Q1i a bond H a bond NH S NH T3h OH
    1089 N O Q1i a bond H a bond NH S NH T3i OH
    1090 N O Q1i a bond H a bond NH S NH T3j OH
    1091 N O Q1i a bond H a bond NH S a bond T3a OH
    1092 N O Q1i a bond H a bond NH S a bond T3b OH
    1093 N O Q1i a bond H a bond NH S a bond T3c OH
    1094 N O Q1i a bond H a bond NH S a bond T3d OH
    1095 N O Q1i a bond H a bond NH S a bond T3e OH
    1096 N O Q1i a bond H a bond NH S a bond T3f OH
    1097 N O Q1i a bond H a bond NH S a bond T3g OH
    1098 N O Q1i a bond H a bond NH S a bond T3h OH
    1099 N O Q1i a bond H a bond NH S a bond T3i OH
    1100 N O Q1i a bond H a bond NH S a bond T3j OH
    1101 N O Q1i a bond H a bond NH O NH T3a OH
    1102 N O Q1i a bond H a bond NH O NH T3b OH
    1103 N O Q1i a bond H a bond NH O NH T3c OH
    1104 N O Q1i a bond H a bond NH O NH T3d OH
    1105 N O Q1i a bond H a bond NH O NH T3e OH
    1106 N O Q1i a bond H a bond NH O NH T3f OH
    1107 N O Q1i a bond H a bond NH O NH T3g OH
    1108 N O Q1i a bond H a bond NH O NH T3h OH
    1109 N O Q1i a bond H a bond NH O NH T3i OH
    1110 N O Q1i a bond H a bond NH O NH T3j OH
    1111 N O Q1i a bond H a bond NH O a bond T3a OH
    1112 N O Q1i a bond H a bond NH O a bond T3b OH
    1113 N O Q1i a bond H a bond NH O a bond T3c OH
    1114 N O Q1i a bond H a bond NH O a bond T3d OH
    1115 N O Q1i a bond H a bond NH O a bond T3e OH
    1116 N O Q1i a bond H a bond NH O a bond T3f OH
    1117 N O Q1i a bond H a bond NH O a bond T3g OH
    1118 N O Q1i a bond H a bond NH O a bond T3h OH
    1119 N O Q1i a bond H a bond NH O a bond T3i OH
    1120 N O Q1i a bond H a bond NH O a bond T3j OH
    1121 N O Q1j a bond Me a bond NH S NH T3a OH
    1122 N O Q1j a bond Me a bond NH S NH T3b OH
    1123 N O Q1j a bond Me a bond NH S NH T3c OH
    1124 N O Q1j a bond Me a bond NH S NH T3d OH
    1125 N O Q1j a bond Me a bond NH S NH T3e OH
    1126 N O Q1j a bond Me a bond NH S NH T3f OH
    1127 N O Q1j a bond Me a bond NH S NH T3g OH
    1128 N O Q1j a bond Me a bond NH S NH T3h OH
    1129 N O Q1j a bond Me a bond NH S NH T3i OH
    1130 N O Q1j a bond Me a bond NH S NH T3j OH
    1131 N O Q1j a bond Me a bond NH S a bond T3a OH
    1132 N O Q1j a bond Me a bond NH S a bond T3b OH
    1133 N O Q1j a bond Me a bond NH S a bond T3c OH
    1134 N O Q1j a bond Me a bond NH S a bond T3d OH
    1135 N O Q1j a bond Me a bond NH S a bond T3e OH
    1136 N O Q1j a bond Me a bond NH S a bond T3f OH
    1137 N O Q1j a bond Me a bond NH S a bond T3g OH
    1138 N O Q1j a bond Me a bond NH S a bond T3h OH
    1139 N O Q1j a bond Me a bond NH S a bond T3i OH
    1140 N O Q1j a bond Me a bond NH S a bond T3j OH
    1141 N O Q1j a bond Me a bond NH O NH T3a OH
    1142 N O Q1j a bond Me a bond NH O NH T3b OH
    1143 N O Q1j a bond Me a bond NH O NH T3c OH
    1144 N O Q1j a bond Me a bond NH O NH T3d OH
    1145 N O Q1j a bond Me a bond NH O NH T3e OH
    1146 N O Q1j a bond Me a bond NH O NH T3f OH
    1147 N O Q1j a bond Me a bond NH O NH T3g OH
    1148 N O Q1j a bond Me a bond NH O NH T3h OH
    1149 N O Q1j a bond Me a bond NH O NH T3i OH
    1150 N O Q1j a bond Me a bond NH O NH T3j OH
    1151 N O Q1j a bond Me a bond NH O a bond T3a OH
    1152 N O Q1j a bond Me a bond NH O a bond T3b OH
    1153 N O Q1j a bond Me a bond NH O a bond T3c OH
    1154 N O Q1j a bond Me a bond NH O a bond T3d OH
    1155 N O Q1j a bond Me a bond NH O a bond T3e OH
    1156 N O Q1j a bond Me a bond NH O a bond T3f OH
    1157 N O Q1j a bond Me a bond NH O a bond T3g OH
    1158 N O Q1j a bond Me a bond NH O a bond T3h OH
    1159 N O Q1j a bond Me a bond NH O a bond T3i OH
    1160 N O Q1j a bond Me a bond NH O a bond T3j OH
    1161 N O Q1j a bond H a bond NH S NH T3a OH
    1162 N O Q1j a bond H a bond NH S NH T3b OH
    1163 N O Q1j a bond H a bond NH S NH T3c OH
    1164 N O Q1j a bond H a bond NH S NH T3d OH
    1165 N O Q1j a bond H a bond NH S NH T3e OH
    1166 N O Q1j a bond H a bond NH S NH T3f OH
    1167 N O Q1j a bond H a bond NH S NH T3g OH
    1168 N O Q1j a bond H a bond NH S NH T3h OH
    1169 N O Q1j a bond H a bond NH S NH T3i OH
    1170 N O Q1j a bond H a bond NH S NH T3j OH
    1171 N O Q1j a bond H a bond NH S a bond T3a OH
    1172 N O Q1j a bond H a bond NH S a bond T3b OH
    1173 N O Q1j a bond H a bond NH S a bond T3c OH
    1174 N O Q1j a bond H a bond NH S a bond T3d OH
    1175 N O Q1j a bond H a bond NH S a bond T3e OH
    1176 N O Q1j a bond H a bond NH S a bond T3f OH
    1177 N O Q1j a bond H a bond NH S a bond T3g OH
    1178 N O Q1j a bond H a bond NH S a bond T3h OH
    1179 N O Q1j a bond H a bond NH S a bond T3i OH
    1180 N O Q1j a bond H a bond NH S a bond T3j OH
    1181 N O Q1j a bond H a bond NH O NH T3a OH
    1182 N O Q1j a bond H a bond NH O NH T3b OH
    1183 N O Q1j a bond H a bond NH O NH T3c OH
    1184 N O Q1j a bond H a bond NH O NH T3d OH
    1185 N O Q1j a bond H a bond NH O NH T3e OH
    1186 N O Q1j a bond H a bond NH O NH T3f OH
    1187 N O Q1j a bond H a bond NH O NH T3g OH
    1188 N O Q1j a bond H a bond NH O NH T3h OH
    1189 N O Q1j a bond H a bond NH O NH T3i OH
    1190 N O Q1j a bond H a bond NH O NH T3j OH
    1191 N O Q1j a bond H a bond NH O a bond T3a OH
    1192 N O Q1j a bond H a bond NH O a bond T3b OH
    1193 N O Q1j a bond H a bond NH O a bond T3c OH
    1194 N O Q1j a bond H a bond NH O a bond T3d OH
    1195 N O Q1j a bond H a bond NH O a bond T3e OH
    1196 N O Q1j a bond H a bond NH O a bond T3f OH
    1197 N O Q1j a bond H a bond NH O a bond T3g OH
    1198 N O Q1j a bond H a bond NH O a bond T3h OH
    1199 N O Q1j a bond H a bond NH O a bond T3i OH
    1200 N O Q1j a bond H a bond NH O a bond T3j OH
    1201 CH NMe Q1a a bond Me a bond NH S NH T3a OH
    1202 CH NMe Q1a a bond Me a bond NH S NH T3b OH
    1203 CH NMe Q1a a bond Me a bond NH S NH T3c OH
    1204 CH NMe Q1a a bond Me a bond NH S NH T3d OH
    1205 CH NMe Q1a a bond Me a bond NH S NH T3e OH
    1206 CH NMe Q1a a bond Me a bond NH S NH T3f OH
    1207 CH NMe Q1a a bond Me a bond NH S NH T3g OH
    1208 CH NMe Q1a a bond Me a bond NH S NH T3h OH
    1209 CH NMe Q1a a bond Me a bond NH S NH T3i OH
    1210 CH NMe Q1a a bond Me a bond NH S NH T3j OH
    1211 CH NMe Q1a a bond Me a bond NH S a bond T3a OH
    1212 CH NMe Q1a a bond Me a bond NH S a bond T3b OH
    1213 CH NMe Q1a a bond Me a bond NH S a bond T3c OH
    1214 CH NMe Q1a a bond Me a bond NH S a bond T3d OH
    1215 CH NMe Q1a a bond Me a bond NH S a bond T3e OH
    1216 CH NMe Q1a a bond Me a bond NH S a bond T3f OH
    1217 CH NMe Q1a a bond Me a bond NH S a bond T3g OH
    1218 CH NMe Q1a a bond Me a bond NH S a bond T3h OH
    1219 CH NMe Q1a a bond Me a bond NH S a bond T3i OH
    1220 CH NMe Q1a a bond Me a bond NH S a bond T3j OH
    1221 CH NMe Q1a a bond Me a bond NH O NH T3a OH
    1222 CH NMe Q1a a bond Me a bond NH O NH T3b OH
    1223 CH NMe Q1a a bond Me a bond NH O NH T3c OH
    1224 CH NMe Q1a a bond Me a bond NH O NH T3d OH
    1225 CH NMe Q1a a bond Me a bond NH O NH T3e OH
    1226 CH NMe Q1a a bond Me a bond NH O NH T3f OH
    1227 CH NMe Q1a a bond Me a bond NH O NH T3g OH
    1228 CH NMe Q1a a bond Me a bond NH O NH T3h OH
    1229 CH NMe Q1a a bond Me a bond NH O NH T3i OH
    1230 CH NMe Q1a a bond Me a bond NH O NH T3j OH
    1231 CH NMe Q1a a bond Me a bond NH O a bond T3a OH
    1232 CH NMe Q1a a bond Me a bond NH O a bond T3b OH
    1233 CH NMe Q1a a bond Me a bond NH O a bond T3c OH
    1234 CH NMe Q1a a bond Me a bond NH O a bond T3d OH
    1235 CH NMe Q1a a bond Me a bond NH O a bond T3e OH
    1236 CH NMe Q1a a bond Me a bond NH O a bond T3f OH
    1237 CH NMe Q1a a bond Me a bond NH O a bond T3g OH
    1238 CH NMe Q1a a bond Me a bond NH O a bond T3h OH
    1239 CH NMe Q1a a bond Me a bond NH O a bond T3i OH
    1240 CH NMe Q1a a bond Me a bond NH O a bond T3j OH
    1241 CH NMe Q1a a bond H a bond NH S NH T3a OH
    1242 CH NMe Q1a a bond H a bond NH S NH T3b OH
    1243 CH NMe Q1a a bond H a bond NH S NH T3c OH
    1244 CH NMe Q1a a bond H a bond NH S NH T3d OH
    1245 CH NMe Q1a a bond H a bond NH S NH T3e OH
    1246 CH NMe Q1a a bond H a bond NH S NH T3f OH
    1247 CH NMe Q1a a bond H a bond NH S NH T3g OH
    1248 CH NMe Q1a a bond H a bond NH S NH T3h OH
    1249 CH NMe Q1a a bond H a bond NH S NH T3i OH
    1250 CH NMe Q1a a bond H a bond NH S NH T3j OH
    1251 CH NMe Q1a a bond H a bond NH S a bond T3a OH
    1252 CH NMe Q1a a bond H a bond NH S a bond T3b OH
    1253 CH NMe Q1a a bond H a bond NH S a bond T3c OH
    1254 CH NMe Q1a a bond H a bond NH S a bond T3d OH
    1255 CH NMe Q1a a bond H a bond NH S a bond T3e OH
    1256 CH NMe Q1a a bond H a bond NH S a bond T3f OH
    1257 CH NMe Q1a a bond H a bond NH S a bond T3g OH
    1258 CH NMe Q1a a bond H a bond NH S a bond T3h OH
    1259 CH NMe Q1a a bond H a bond NH S a bond T3i OH
    1260 CH NMe Q1a a bond H a bond NH S a bond T3j OH
    1261 CH NMe Q1a a bond H a bond NH O NH T3a OH
    1262 CH NMe Q1a a bond H a bond NH O NH T3b OH
    1263 CH NMe Q1a a bond H a bond NH O NH T3c OH
    1264 CH NMe Q1a a bond H a bond NH O NH T3d OH
    1265 CH NMe Q1a a bond H a bond NH O NH T3e OH
    1266 CH NMe Q1a a bond H a bond NH O NH T3f OH
    1267 CH NMe Q1a a bond H a bond NH O NH T3g OH
    1268 CH NMe Q1a a bond H a bond NH O NH T3h OH
    1269 CH NMe Q1a a bond H a bond NH O NH T3i OH
    1270 CH NMe Q1a a bond H a bond NH O NH T3j OH
    1271 CH NMe Q1a a bond H a bond NH O a bond T3a OH
    1272 CH NMe Q1a a bond H a bond NH O a bond T3b OH
    1273 CH NMe Q1a a bond H a bond NH O a bond T3c OH
    1274 CH NMe Q1a a bond H a bond NH O a bond T3d OH
    1275 CH NMe Q1a a bond H a bond NH O a bond T3e OH
    1276 CH NMe Q1a a bond H a bond NH O a bond T3f OH
    1277 CH NMe Q1a a bond H a bond NH O a bond T3g OH
    1278 CH NMe Q1a a bond H a bond NH O a bond T3h OH
    1279 CH NMe Q1a a bond H a bond NH O a bond T3i OH
    1280 CH NMe Q1a a bond H a bond NH O a bond T3j OH
    1281 CH NMe Q1b a bond Me a bond NH S NH T3a OH
    1282 CH NMe Q1b a bond Me a bond NH S NH T3b OH
    1283 CH NMe Q1b a bond Me a bond NH S NH T3c OH
    1284 CH NMe Q1b a bond Me a bond NH S NH T3d OH
    1285 CH NMe Q1b a bond Me a bond NH S NH T3e OH
    1286 CH NMe Q1b a bond Me a bond NH S NH T3f OH
    1287 CH NMe Q1b a bond Me a bond NH S NH T3g OH
    1288 CH NMe Q1b a bond Me a bond NH S NH T3h OH
    1289 CH NMe Q1b a bond Me a bond NH S NH T3i OH
    1290 CH NMe Q1b a bond Me a bond NH S NH T3j OH
    1291 CH NMe Q1b a bond Me a bond NH S a bond T3a OH
    1292 CH NMe Q1b a bond Me a bond NH S a bond T3b OH
    1293 CH NMe Q1b a bond Me a bond NH S a bond T3c OH
    1294 CH NMe Q1b a bond Me a bond NH S a bond T3d OH
    1295 CH NMe Q1b a bond Me a bond NH S a bond T3e OH
    1296 CH NMe Q1b a bond Me a bond NH S a bond T3f OH
    1297 CH NMe Q1b a bond Me a bond NH S a bond T3g OH
    1298 CH NMe Q1b a bond Me a bond NH S a bond T3h OH
    1299 CH NMe Q1b a bond Me a bond NH S a bond T3i OH
    1300 CH NMe Q1b a bond Me a bond NH S a bond T3j OH
    1301 CH NMe Q1b a bond Me a bond NH O NH T3a OH
    1302 CH NMe Q1b a bond Me a bond NH O NH T3b OH
    1303 CH NMe Q1b a bond Me a bond NH O NH T3c OH
    1304 CH NMe Q1b a bond Me a bond NH O NH T3d OH
    1305 CH NMe Q1b a bond Me a bond NH O NH T3e OH
    1306 CH NMe Q1b a bond Me a bond NH O NH T3f OH
    1307 CH NMe Q1b a bond Me a bond NH O NH T3g OH
    1308 CH NMe Q1b a bond Me a bond NH O NH T3h OH
    1309 CH NMe Q1b a bond Me a bond NH O NH T3i OH
    1310 CH NMe Q1b a bond Me a bond NH O NH T3j OH
    1311 CH NMe Q1b a bond Me a bond NH O a bond T3a OH
    1312 CH NMe Q1b a bond Me a bond NH O a bond T3b OH
    1313 CH NMe Q1b a bond Me a bond NH O a bond T3c OH
    1314 CH NMe Q1b a bond Me a bond NH O a bond T3d OH
    1315 CH NMe Q1b a bond Me a bond NH O a bond T3e OH
    1316 CH NMe Q1b a bond Me a bond NH O a bond T3f OH
    1317 CH NMe Q1b a bond Me a bond NH O a bond T3g OH
    1318 CH NMe Q1b a bond Me a bond NH O a bond T3h OH
    1319 CH NMe Q1b a bond Me a bond NH O a bond T3i OH
    1320 CH NMe Q1b a bond Me a bond NH O a bond T3j OH
    1321 CH NMe Q1b a bond H a bond NH S NH T3a OH
    1322 CH NMe Q1b a bond H a bond NH S NH T3b OH
    1323 CH NMe Q1b a bond H a bond NH S NH T3c OH
    1324 CH NMe Q1b a bond H a bond NH S NH T3d OH
    1325 CH NMe Q1b a bond H a bond NH S NH T3e OH
    1326 CH NMe Q1b a bond H a bond NH S NH T3f OH
    1327 CH NMe Q1b a bond H a bond NH S NH T3g OH
    1328 CH NMe Q1b a bond H a bond NH S NH T3h OH
    1329 CH NMe Q1b a bond H a bond NH S NH T3i OH
    1330 CH NMe Q1b a bond H a bond NH S NH T3j OH
    1331 CH NMe Q1b a bond H a bond NH S a bond T3a OH
    1332 CH NMe Q1b a bond H a bond NH S a bond T3b OH
    1333 CH NMe Q1b a bond H a bond NH S a bond T3c OH
    1334 CH NMe Q1b a bond H a bond NH S a bond T3d OH
    1335 CH NMe Q1b a bond H a bond NH S a bond T3e OH
    1336 CH NMe Q1b a bond H a bond NH S a bond T3f OH
    1337 CH NMe Q1b a bond H a bond NH S a bond T3g OH
    1338 CH NMe Q1b a bond H a bond NH S a bond T3h OH
    1339 CH NMe Q1b a bond H a bond NH S a bond T3i OH
    1340 CH NMe Q1b a bond H a bond NH S a bond T3j OH
    1341 CH NMe Q1b a bond H a bond NH O NH T3a OH
    1342 CH NMe Q1b a bond H a bond NH O NH T3b OH
    1343 CH NMe Q1b a bond H a bond NH O NH T3c OH
    1344 CH NMe Q1b a bond H a bond NH O NH T3d OH
    1345 CH NMe Q1b a bond H a bond NH O NH T3e OH
    1346 CH NMe Q1b a bond H a bond NH O NH T3f OH
    1347 CH NMe Q1b a bond H a bond NH O NH T3g OH
    1348 CH NMe Q1b a bond H a bond NH O NH T3h OH
    1349 CH NMe Q1b a bond H a bond NH O NH T3i OH
    1350 CH NMe Q1b a bond H a bond NH O NH T3j OH
    1351 CH NMe Q1b a bond H a bond NH O a bond T3a OH
    1352 CH NMe Q1b a bond H a bond NH O a bond T3b OH
    1353 CH NMe Q1b a bond H a bond NH O a bond T3c OH
    1354 CH NMe Q1b a bond H a bond NH O a bond T3d OH
    1355 CH NMe Q1b a bond H a bond NH O a bond T3e OH
    1356 CH NMe Q1b a bond H a bond NH O a bond T3f OH
    1357 CH NMe Q1b a bond H a bond NH O a bond T3g OH
    1358 CH NMe Q1b a bond H a bond NH O a bond T3h OH
    1359 CH NMe Q1b a bond H a bond NH O a bond T3i OH
    1360 CH NMe Q1b a bond H a bond NH O a bond T3j OH
    1361 CH NMe Q1c a bond Me a bond NH S NH T3a OH
    1362 CH NMe Q1c a bond Me a bond NH S NH T3b OH
    1363 CH NMe Q1c a bond Me a bond NH S NH T3c OH
    1364 CH NMe Q1c a bond Me a bond NH S NH T3d OH
    1365 CH NMe Q1c a bond Me a bond NH S NH T3e OH
    1366 CH NMe Q1c a bond Me a bond NH S NH T3f OH
    1367 CH NMe Q1c a bond Me a bond NH S NH T3g OH
    1368 CH NMe Q1c a bond Me a bond NH S NH T3h OH
    1369 CH NMe Q1c a bond Me a bond NH S NH T3i OH
    1370 CH NMe Q1c a bond Me a bond NH S NH T3j OH
    1371 CH NMe Q1c a bond Me a bond NH S a bond T3a OH
    1372 CH NMe Q1c a bond Me a bond NH S a bond T3b OH
    1373 CH NMe Q1c a bond Me a bond NH S a bond T3c OH
    1374 CH NMe Q1c a bond Me a bond NH S a bond T3d OH
    1375 CH NMe Q1c a bond Me a bond NH S a bond T3e OH
    1376 CH NMe Q1c a bond Me a bond NH S a bond T3f OH
    1377 CH NMe Q1c a bond Me a bond NH S a bond T3g OH
    1378 CH NMe Q1c a bond Me a bond NH S a bond T3h OH
    1379 CH NMe Q1c a bond Me a bond NH S a bond T3i OH
    1380 CH NMe Q1c a bond Me a bond NH S a bond T3j OH
    1381 CH NMe Q1c a bond Me a bond NH O NH T3a OH
    1382 CH NMe Q1c a bond Me a bond NH O NH T3b OH
    1383 CH NMe Q1c a bond Me a bond NH O NH T3c OH
    1384 CH NMe Q1c a bond Me a bond NH O NH T3d OH
    1385 CH NMe Q1c a bond Me a bond NH O NH T3e OH
    1386 CH NMe Q1c a bond Me a bond NH O NH T3f OH
    1387 CH NMe Q1c a bond Me a bond NH O NH T3g OH
    1388 CH NMe Q1c a bond Me a bond NH O NH T3h OH
    1389 CH NMe Q1c a bond Me a bond NH O NH T3i OH
    1390 CH NMe Q1c a bond Me a bond NH O NH T3j OH
    1391 CH NMe Q1c a bond Me a bond NH O a bond T3a OH
    1392 CH NMe Q1c a bond Me a bond NH O a bond T3b OH
    1393 CH NMe Q1c a bond Me a bond NH O a bond T3c OH
    1394 CH NMe Q1c a bond Me a bond NH O a bond T3d OH
    1395 CH NMe Q1c a bond Me a bond NH O a bond T3e OH
    1396 CH NMe Q1c a bond Me a bond NH O a bond T3f OH
    1397 CH NMe Q1c a bond Me a bond NH O a bond T3g OH
    1398 CH NMe Q1c a bond Me a bond NH O a bond T3h OH
    1399 CH NMe Q1c a bond Me a bond NH O a bond T3i OH
    1400 CH NMe Q1c a bond Me a bond NH O a bond T3j OH
    1401 CH NMe Q1c a bond H a bond NH S NH T3a OH
    1402 CH NMe Q1c a bond H a bond NH S NH T3b OH
    1403 CH NMe Q1c a bond H a bond NH S NH T3c OH
    1404 CH NMe Q1c a bond H a bond NH S NH T3d OH
    1405 CH NMe Q1c a bond H a bond NH S NH T3e OH
    1406 CH NMe Q1c a bond H a bond NH S NH T3f OH
    1407 CH NMe Q1c a bond H a bond NH S NH T3g OH
    1408 CH NMe Q1c a bond H a bond NH S NH T3h OH
    1409 CH NMe Q1c a bond H a bond NH S NH T3i OH
    1410 CH NMe Q1c a bond H a bond NH S NH T3j OH
    1411 CH NMe Q1c a bond H a bond NH S a bond T3a OH
    1412 CH NMe Q1c a bond H a bond NH S a bond T3b OH
    1413 CH NMe Q1c a bond H a bond NH S a bond T3c OH
    1414 CH NMe Q1c a bond H a bond NH S a bond T3d OH
    1415 CH NMe Q1c a bond H a bond NH S a bond T3e OH
    1416 CH NMe Q1c a bond H a bond NH S a bond T3f OH
    1417 CH NMe Q1c a bond H a bond NH S a bond T3g OH
    1418 CH NMe Q1c a bond H a bond NH S a bond T3h OH
    1419 CH NMe Q1c a bond H a bond NH S a bond T3i OH
    1420 CH NMe Q1c a bond H a bond NH S a bond T3j OH
    1421 CH NMe Q1c a bond H a bond NH O NH T3a OH
    1422 CH NMe Q1c a bond H a bond NH O NH T3b OH
    1423 CH NMe Q1c a bond H a bond NH O NH T3c OH
    1424 CH NMe Q1c a bond H a bond NH O NH T3d OH
    1425 CH NMe Q1c a bond H a bond NH O NH T3e OH
    1426 CH NMe Q1c a bond H a bond NH O NH T3f OH
    1427 CH NMe Q1c a bond H a bond NH O NH T3g OH
    1428 CH NMe Q1c a bond H a bond NH O NH T3h OH
    1429 CH NMe Q1c a bond H a bond NH O NH T3i OH
    1430 CH NMe Q1c a bond H a bond NH O NH T3j OH
    1431 CH NMe Q1c a bond H a bond NH O a bond T3a OH
    1432 CH NMe Q1c a bond H a bond NH O a bond T3b OH
    1433 CH NMe Q1c a bond H a bond NH O a bond T3c OH
    1434 CH NMe Q1c a bond H a bond NH O a bond T3d OH
    1435 CH NMe Q1c a bond H a bond NH O a bond T3e OH
    1436 CH NMe Q1c a bond H a bond NH O a bond T3f OH
    1437 CH NMe Q1c a bond H a bond NH O a bond T3g OH
    1438 CH NMe Q1c a bond H a bond NH O a bond T3h OH
    1439 CH NMe Q1c a bond H a bond NH O a bond T3i OH
    1440 CH NMe Q1c a bond H a bond NH O a bond T3j OH
    1441 CH NMe Q1i a bond Me a bond NH S NH T3a OH
    1442 CH NMe Q1i a bond Me a bond NH S NH T3b OH
    1443 CH NMe Q1i a bond Me a bond NH S NH T3c OH
    1444 CH NMe Q1i a bond Me a bond NH S NH T3d OH
    1445 CH NMe Q1i a bond Me a bond NH S NH T3e OH
    1446 CH NMe Q1i a bond Me a bond NH S NH T3f OH
    1447 CH NMe Q1i a bond Me a bond NH S NH T3g OH
    1448 CH NMe Q1i a bond Me a bond NH S NH T3h OH
    1449 CH NMe Q1i a bond Me a bond NH S NH T3i OH
    1450 CH NMe Q1i a bond Me a bond NH S NH T3j OH
    1451 CH NMe Q1i a bond Me a bond NH S a bond T3a OH
    1452 CH NMe Q1i a bond Me a bond NH S a bond T3b OH
    1453 CH NMe Q1i a bond Me a bond NH S a bond T3c OH
    1454 CH NMe Q1i a bond Me a bond NH S a bond T3d OH
    1455 CH NMe Q1i a bond Me a bond NH S a bond T3e OH
    1456 CH NMe Q1i a bond Me a bond NH S a bond T3f OH
    1457 CH NMe Q1i a bond Me a bond NH S a bond T3g OH
    1458 CH NMe Q1i a bond Me a bond NH S a bond T3h OH
    1459 CH NMe Q1i a bond Me a bond NH S a bond T3i OH
    1460 CH NMe Q1i a bond Me a bond NH S a bond T3j OH
    1461 CH NMe Q1i a bond Me a bond NH O NH T3a OH
    1462 CH NMe Q1i a bond Me a bond NH O NH T3b OH
    1463 CH NMe Q1i a bond Me a bond NH O NH T3c OH
    1464 CH NMe Q1i a bond Me a bond NH O NH T3d OH
    1465 CH NMe Q1i a bond Me a bond NH O NH T3e OH
    1466 CH NMe Q1i a bond Me a bond NH O NH T3f OH
    1467 CH NMe Q1i a bond Me a bond NH O NH T3g OH
    1468 CH NMe Q1i a bond Me a bond NH O NH T3h OH
    1469 CH NMe Q1i a bond Me a bond NH O NH T3i OH
    1470 CH NMe Q1i a bond Me a bond NH O NH T3j OH
    1471 CH NMe Q1i a bond Me a bond NH O a bond T3a OH
    1472 CH NMe Q1i a bond Me a bond NH O a bond T3b OH
    1473 CH NMe Q1i a bond Me a bond NH O a bond T3c OH
    1474 CH NMe Q1i a bond Me a bond NH O a bond T3d OH
    1475 CH NMe Q1i a bond Me a bond NH O a bond T3e OH
    1476 CH NMe Q1i a bond Me a bond NH O a bond T3f OH
    1477 CH NMe Q1i a bond Me a bond NH O a bond T3g OH
    1478 CH NMe Q1i a bond Me a bond NH O a bond T3h OH
    1479 CH NMe Q1i a bond Me a bond NH O a bond T3i OH
    1480 CH NMe Q1i a bond Me a bond NH O a bond T3j OH
    1481 CH NMe Q1i a bond H a bond NH S NH T3a OH
    1482 CH NMe Q1i a bond H a bond NH S NH T3b OH
    1483 CH NMe Q1i a bond H a bond NH S NH T3c OH
    1484 CH NMe Q1i a bond H a bond NH S NH T3d OH
    1485 CH NMe Q1i a bond H a bond NH S NH T3e OH
    1486 CH NMe Q1i a bond H a bond NH S NH T3f OH
    1487 CH NMe Q1i a bond H a bond NH S NH T3g OH
    1488 CH NMe Q1i a bond H a bond NH S NH T3h OH
    1489 CH NMe Q1i a bond H a bond NH S NH T3i OH
    1490 CH NMe Q1i a bond H a bond NH S NH T3j OH
    1491 CH NMe Q1i a bond H a bond NH S a bond T3a OH
    1492 CH NMe Q1i a bond H a bond NH S a bond T3b OH
    1493 CH NMe Q1i a bond H a bond NH S a bond T3c OH
    1494 CH NMe Q1i a bond H a bond NH S a bond T3d OH
    1495 CH NMe Q1i a bond H a bond NH S a bond T3e OH
    1496 CH NMe Q1i a bond H a bond NH S a bond T3f OH
    1497 CH NMe Q1i a bond H a bond NH S a bond T3g OH
    1498 CH NMe Q1i a bond H a bond NH S a bond T3h OH
    1499 CH NMe Q1i a bond H a bond NH S a bond T3i OH
    1500 CH NMe Q1i a bond H a bond NH S a bond T3j OH
    1501 CH NMe Q1i a bond H a bond NH O NH T3a OH
    1502 CH NMe Q1i a bond H a bond NH O NH T3b OH
    1503 CH NMe Q1i a bond H a bond NH O NH T3c OH
    1504 CH NMe Q1i a bond H a bond NH O NH T3d OH
    1505 CH NMe Q1i a bond H a bond NH O NH T3e OH
    1506 CH NMe Q1i a bond H a bond NH O NH T3f OH
    1507 CH NMe Q1i a bond H a bond NH O NH T3g OH
    1508 CH NMe Q1i a bond H a bond NH O NH T3h OH
    1509 CH NMe Q1i a bond H a bond NH O NH T3i OH
    1510 CH NMe Q1i a bond H a bond NH O NH T3j OH
    1511 CH NMe Q1i a bond H a bond NH O a bond T3a OH
    1512 CH NMe Q1i a bond H a bond NH O a bond T3b OH
    1513 CH NMe Q1i a bond H a bond NH O a bond T3c OH
    1514 CH NMe Q1i a bond H a bond NH O a bond T3d OH
    1515 CH NMe Q1i a bond H a bond NH O a bond T3e OH
    1516 CH NMe Q1i a bond H a bond NH O a bond T3f OH
    1517 CH NMe Q1i a bond H a bond NH O a bond T3g OH
    1518 CH NMe Q1i a bond H a bond NH O a bond T3h OH
    1519 CH NMe Q1i a bond H a bond NH O a bond T3i OH
    1520 CH NMe Q1i a bond H a bond NH O a bond T3j OH
    1521 CH NMe Q1j a bond Me a bond NH S NH T3a OH
    1522 CH NMe Q1j a bond Me a bond NH S NH T3b OH
    1523 CH NMe Q1j a bond Me a bond NH S NH T3c OH
    1524 CH NMe Q1j a bond Me a bond NH S NH T3d OH
    1525 CH NMe Q1j a bond Me a bond NH S NH T3e OH
    1526 CH NMe Q1j a bond Me a bond NH S NH T3f OH
    1527 CH NMe Q1j a bond Me a bond NH S NH T3g OH
    1528 CH NMe Q1j a bond Me a bond NH S NH T3h OH
    1529 CH NMe Q1j a bond Me a bond NH S NH T3i OH
    1530 CH NMe Q1j a bond Me a bond NH S NH T3j OH
    1531 CH NMe Q1j a bond Me a bond NH S a bond T3a OH
    1532 CH NMe Q1j a bond Me a bond NH S a bond T3b OH
    1533 CH NMe Q1j a bond Me a bond NH S a bond T3c OH
    1534 CH NMe Q1j a bond Me a bond NH S a bond T3d OH
    1535 CH NMe Q1j a bond Me a bond NH S a bond T3e OH
    1536 CH NMe Q1j a bond Me a bond NH S a bond T3f OH
    1537 CH NMe Q1j a bond Me a bond NH S a bond T3g OH
    1538 CH NMe Q1j a bond Me a bond NH S a bond T3h OH
    1539 CH NMe Q1j a bond Me a bond NH S a bond T3i OH
    1540 CH NMe Q1j a bond Me a bond NH S a bond T3j OH
    1541 CH NMe Q1j a bond Me a bond NH O NH T3a OH
    1542 CH NMe Q1j a bond Me a bond NH O NH T3b OH
    1543 CH NMe Q1j a bond Me a bond NH O NH T3c OH
    1544 CH NMe Q1j a bond Me a bond NH O NH T3d OH
    1545 CH NMe Q1j a bond Me a bond NH O NH T3e OH
    1546 CH NMe Q1j a bond Me a bond NH O NH T3f OH
    1547 CH NMe Q1j a bond Me a bond NH O NH T3g OH
    1548 CH NMe Q1j a bond Me a bond NH O NH T3h OH
    1549 CH NMe Q1j a bond Me a bond NH O NH T3i OH
    1550 CH NMe Q1j a bond Me a bond NH O NH T3j OH
    1551 CH NMe Q1j a bond Me a bond NH O a bond T3a OH
    1552 CH NMe Q1j a bond Me a bond NH O a bond T3b OH
    1553 CH NMe Q1j a bond Me a bond NH O a bond T3c OH
    1554 CH NMe Q1j a bond Me a bond NH O a bond T3d OH
    1555 CH NMe Q1j a bond Me a bond NH O a bond T3e OH
    1556 CH NMe Q1j a bond Me a bond NH O a bond T3f OH
    1557 CH NMe Q1j a bond Me a bond NH O a bond T3g OH
    1558 CH NMe Q1j a bond Me a bond NH O a bond T3h OH
    1559 CH NMe Q1j a bond Me a bond NH O a bond T3i OH
    1560 CH NMe Q1j a bond Me a bond NH O a bond T3j OH
    1561 CH NMe Q1j a bond H a bond NH S NH T3a OH
    1562 CH NMe Q1j a bond H a bond NH S NH T3b OH
    1563 CH NMe Q1j a bond H a bond NH S NH T3c OH
    1564 CH NMe Q1j a bond H a bond NH S NH T3d OH
    1565 CH NMe Q1j a bond H a bond NH S NH T3e OH
    1566 CH NMe Q1j a bond H a bond NH S NH T3f OH
    1567 CH NMe Q1j a bond H a bond NH S NH T3g OH
    1568 CH NMe Q1j a bond H a bond NH S NH T3h OH
    1569 CH NMe Q1j a bond H a bond NH S NH T3i OH
    1570 CH NMe Q1j a bond H a bond NH S NH T3j OH
    1571 CH NMe Q1j a bond H a bond NH S a bond T3a OH
    1572 CH NMe Q1j a bond H a bond NH S a bond T3b OH
    1573 CH NMe Q1j a bond H a bond NH S a bond T3c OH
    1574 CH NMe Q1j a bond H a bond NH S a bond T3d OH
    1575 CH NMe Q1j a bond H a bond NH S a bond T3e OH
    1576 CH NMe Q1j a bond H a bond NH S a bond T3f OH
    1577 CH NMe Q1j a bond H a bond NH S a bond T3g OH
    1578 CH NMe Q1j a bond H a bond NH S a bond T3h OH
    1579 CH NMe Q1j a bond H a bond NH S a bond T3i OH
    1580 CH NMe Q1j a bond H a bond NH S a bond T3j OH
    1581 CH NMe Q1j a bond H a bond NH O NH T3a OH
    1582 CH NMe Q1j a bond H a bond NH O NH T3b OH
    1583 CH NMe Q1j a bond H a bond NH O NH T3c OH
    1584 CH NMe Q1j a bond H a bond NH O NH T3d OH
    1585 CH NMe Q1j a bond H a bond NH O NH T3e OH
    1586 CH NMe Q1j a bond H a bond NH O NH T3f OH
    1587 CH NMe Q1j a bond H a bond NH O NH T3g OH
    1588 CH NMe Q1j a bond H a bond NH O NH T3h OH
    1589 CH NMe Q1j a bond H a bond NH O NH T3i OH
    1590 CH NMe Q1j a bond H a bond NH O NH T3j OH
    1591 CH NMe Q1j a bond H a bond NH O a bond T3a OH
    1592 CH NMe Q1j a bond H a bond NH O a bond T3b OH
    1593 CH NMe Q1j a bond H a bond NH O a bond T3c OH
    1594 CH NMe Q1j a bond H a bond NH O a bond T3d OH
    1595 CH NMe Q1j a bond H a bond NH O a bond T3e OH
    1596 CH NMe Q1j a bond H a bond NH O a bond T3f OH
    1597 CH NMe Q1j a bond H a bond NH O a bond T3g OH
    1598 CH NMe Q1j a bond H a bond NH O a bond T3h OH
    1599 CH NMe Q1j a bond H a bond NH O a bond T3i OH
    1600 CH NMe Q1j a bond H a bond NH O a bond T3j OH
    1601 CH S Q1a a bond Me a bond NH S NH T3a OH
    1602 CH S Q1a a bond Me a bond NH S NH T3b OH
    1603 CH S Q1a a bond Me a bond NH S NH T3c OH
    1604 CH S Q1a a bond Me a bond NH S NH T3d OH
    1605 CH S Q1a a bond Me a bond NH S NH T3e OH
    1606 CH S Q1a a bond Me a bond NH S NH T3f OH
    1607 CH S Q1a a bond Me a bond NH S NH T3g OH
    1608 CH S Q1a a bond Me a bond NH S NH T3h OH
    1609 CH S Q1a a bond Me a bond NH S NH T3i OH
    1610 CH S Q1a a bond Me a bond NH S NH T3j OH
    1611 CH S Q1a a bond Me a bond NH S a bond T3a OH
    1612 CH S Q1a a bond Me a bond NH S a bond T3b OH
    1613 CH S Q1a a bond Me a bond NH S a bond T3c OH
    1614 CH S Q1a a bond Me a bond NH S a bond T3d OH
    1615 CH S Q1a a bond Me a bond NH S a bond T3e OH
    1616 CH S Q1a a bond Me a bond NH S a bond T3f OH
    1617 CH S Q1a a bond Me a bond NH S a bond T3g OH
    1618 CH S Q1a a bond Me a bond NH S a bond T3h OH
    1619 CH S Q1a a bond Me a bond NH S a bond T3i OH
    1620 CH S Q1a a bond Me a bond NH S a bond T3j OH
    1621 CH S Q1a a bond Me a bond NH O NH T3a OH
    1622 CH S Q1a a bond Me a bond NH O NH T3b OH
    1623 CH S Q1a a bond Me a bond NH O NH T3c OH
    1624 CH S Q1a a bond Me a bond NH O NH T3d OH
    1625 CH S Q1a a bond Me a bond NH O NH T3e OH
    1626 CH S Q1a a bond Me a bond NH O NH T3f OH
    1627 CH S Q1a a bond Me a bond NH O NH T3g OH
    1628 CH S Q1a a bond Me a bond NH O NH T3h OH
    1629 CH S Q1a a bond Me a bond NH O NH T3i OH
    1630 CH S Q1a a bond Me a bond NH O NH T3j OH
    1631 CH S Q1a a bond Me a bond NH O a bond T3a OH
    1632 CH S Q1a a bond Me a bond NH O a bond T3b OH
    1633 CH S Q1a a bond Me a bond NH O a bond T3c OH
    1634 CH S Q1a a bond Me a bond NH O a bond T3d OH
    1635 CH S Q1a a bond Me a bond NH O a bond T3e OH
    1636 CH S Q1a a bond Me a bond NH O a bond T3f OH
    1637 CH S Q1a a bond Me a bond NH O a bond T3g OH
    1638 CH S Q1a a bond Me a bond NH O a bond T3h OH
    1639 CH S Q1a a bond Me a bond NH O a bond T3i OH
    1640 CH S Q1a a bond Me a bond NH O a bond T3j OH
    1641 CH S Q1a a bond H a bond NH S NH T3a OH
    1642 CH S Q1a a bond H a bond NH S NH T3b OH
    1643 CH S Q1a a bond H a bond NH S NH T3c OH
    1644 CH S Q1a a bond H a bond NH S NH T3d OH
    1645 CH S Q1a a bond H a bond NH S NH T3e OH
    1646 CH S Q1a a bond H a bond NH S NH T3f OH
    1647 CH S Q1a a bond H a bond NH S NH T3g OH
    1648 CH S Q1a a bond H a bond NH S NH T3h OH
    1649 CH S Q1a a bond H a bond NH S NH T3i OH
    1650 CH S Q1a a bond H a bond NH S NH T3j OH
    1651 CH S Q1a a bond H a bond NH S a bond T3a OH
    1652 CH S Q1a a bond H a bond NH S a bond T3b OH
    1653 CH S Q1a a bond H a bond NH S a bond T3c OH
    1654 CH S Q1a a bond H a bond NH S a bond T3d OH
    1655 CH S Q1a a bond H a bond NH S a bond T3e OH
    1656 CH S Q1a a bond H a bond NH S a bond T3f OH
    1657 CH S Q1a a bond H a bond NH S a bond T3g OH
    1658 CH S Q1a a bond H a bond NH S a bond T3h OH
    1659 CH S Q1a a bond H a bond NH S a bond T3i OH
    1660 CH S Q1a a bond H a bond NH S a bond T3j OH
    1661 CH S Q1a a bond H a bond NH O NH T3a OH
    1662 CH S Q1a a bond H a bond NH O NH T3b OH
    1663 CH S Q1a a bond H a bond NH O NH T3c OH
    1664 CH S Q1a a bond H a bond NH O NH T3d OH
    1665 CH S Q1a a bond H a bond NH O NH T3e OH
    1666 CH S Q1a a bond H a bond NH O NH T3f OH
    1667 CH S Q1a a bond H a bond NH O NH T3g OH
    1668 CH S Q1a a bond H a bond NH O NH T3h OH
    1669 CH S Q1a a bond H a bond NH O NH T3i OH
    1670 CH S Q1a a bond H a bond NH O NH T3j OH
    1671 CH S Q1a a bond H a bond NH O a bond T3a OH
    1672 CH S Q1a a bond H a bond NH O a bond T3b OH
    1673 CH S Q1a a bond H a bond NH O a bond T3c OH
    1674 CH S Q1a a bond H a bond NH O a bond T3d OH
    1675 CH S Q1a a bond H a bond NH O a bond T3e OH
    1676 CH S Q1a a bond H a bond NH O a bond T3f OH
    1677 CH S Q1a a bond H a bond NH O a bond T3g OH
    1678 CH S Q1a a bond H a bond NH O a bond T3h OH
    1679 CH S Q1a a bond H a bond NH O a bond T3i OH
    1680 CH S Q1a a bond H a bond NH O a bond T3j OH
    1681 CH S Q1b a bond Me a bond NH S NH T3a OH
    1682 CH S Q1b a bond Me a bond NH S NH T3b OH
    1683 CH S Q1b a bond Me a bond NH S NH T3c OH
    1684 CH S Q1b a bond Me a bond NH S NH T3d OH
    1685 CH S Q1b a bond Me a bond NH S NH T3e OH
    1686 CH S Q1b a bond Me a bond NH S NH T3f OH
    1687 CH S Q1b a bond Me a bond NH S NH T3g OH
    1688 CH S Q1b a bond Me a bond NH S NH T3h OH
    1689 CH S Q1b a bond Me a bond NH S NH T3i OH
    1690 CH S Q1b a bond Me a bond NH S NH T3j OH
    1691 CH S Q1b a bond Me a bond NH S a bond T3a OH
    1692 CH S Q1b a bond Me a bond NH S a bond T3b OH
    1693 CH S Q1b a bond Me a bond NH S a bond T3c OH
    1694 CH S Q1b a bond Me a bond NH S a bond T3d OH
    1695 CH S Q1b a bond Me a bond NH S a bond T3e OH
    1696 CH S Q1b a bond Me a bond NH S a bond T3f OH
    1697 CH S Q1b a bond Me a bond NH S a bond T3g OH
    1698 CH S Q1b a bond Me a bond NH S a bond T3h OH
    1699 CH S Q1b a bond Me a bond NH S a bond T3i OH
    1700 CH S Q1b a bond Me a bond NH S a bond T3j OH
    1701 CH S Q1b a bond Me a bond NH O NH T3a OH
    1702 CH S Q1b a bond Me a bond NH O NH T3b OH
    1703 CH S Q1b a bond Me a bond NH O NH T3c OH
    1704 CH S Q1b a bond Me a bond NH O NH T3d OH
    1705 CH S Q1b a bond Me a bond NH O NH T3e OH
    1706 CH S Q1b a bond Me a bond NH O NH T3f OH
    1707 CH S Q1b a bond Me a bond NH O NH T3g OH
    1708 CH S Q1b a bond Me a bond NH O NH T3h OH
    1709 CH S Q1b a bond Me a bond NH O NH T3i OH
    1710 CH S Q1b a bond Me a bond NH O NH T3j OH
    1711 CH S Q1b a bond Me a bond NH O a bond T3a OH
    1712 CH S Q1b a bond Me a bond NH O a bond T3b OH
    1713 CH S Q1b a bond Me a bond NH O a bond T3c OH
    1714 CH S Q1b a bond Me a bond NH O a bond T3d OH
    1715 CH S Q1b a bond Me a bond NH O a bond T3e OH
    1716 CH S Q1b a bond Me a bond NH O a bond T3f OH
    1717 CH S Q1b a bond Me a bond NH O a bond T3g OH
    1718 CH S Q1b a bond Me a bond NH O a bond T3h OH
    1719 CH S Q1b a bond Me a bond NH O a bond T3i OH
    1720 CH S Q1b a bond Me a bond NH O a bond T3j OH
    1721 CH S Q1b a bond H a bond NH S NH T3a OH
    1722 CH S Q1b a bond H a bond NH S NH T3b OH
    1723 CH S Q1b a bond H a bond NH S NH T3c OH
    1724 CH S Q1b a bond H a bond NH S NH T3d OH
    1725 CH S Q1b a bond H a bond NH S NH T3e OH
    1726 CH S Q1b a bond H a bond NH S NH T3f OH
    1727 CH S Q1b a bond H a bond NH S NH T3g OH
    1728 CH S Q1b a bond H a bond NH S NH T3h OH
    1729 CH S Q1b a bond H a bond NH S NH T3i OH
    1730 CH S Q1b a bond H a bond NH S NH T3j OH
    1731 CH S Q1b a bond H a bond NH S a bond T3a OH
    1732 CH S Q1b a bond H a bond NH S a bond T3b OH
    1733 CH S Q1b a bond H a bond NH S a bond T3c OH
    1734 CH S Q1b a bond H a bond NH S a bond T3d OH
    1735 CH S Q1b a bond H a bond NH S a bond T3e OH
    1736 CH S Q1b a bond H a bond NH S a bond T3f OH
    1737 CH S Q1b a bond H a bond NH S a bond T3g OH
    1738 CH S Q1b a bond H a bond NH S a bond T3h OH
    1739 CH S Q1b a bond H a bond NH S a bond T3i OH
    1740 CH S Q1b a bond H a bond NH S a bond T3j OH
    1741 CH S Q1b a bond H a bond NH O NH T3a OH
    1742 CH S Q1b a bond H a bond NH O NH T3b OH
    1743 CH S Q1b a bond H a bond NH O NH T3c OH
    1744 CH S Q1b a bond H a bond NH O NH T3d OH
    1745 CH S Q1b a bond H a bond NH O NH T3e OH
    1746 CH S Q1b a bond H a bond NH O NH T3f OH
    1747 CH S Q1b a bond H a bond NH O NH T3g OH
    1748 CH S Q1b a bond H a bond NH O NH T3h OH
    1749 CH S Q1b a bond H a bond NH O NH T3i OH
    1750 CH S Q1b a bond H a bond NH O NH T3j OH
    1751 CH S Q1b a bond H a bond NH O a bond T3a OH
    1752 CH S Q1b a bond H a bond NH O a bond T3b OH
    1753 CH S Q1b a bond H a bond NH O a bond T3c OH
    1754 CH S Q1b a bond H a bond NH O a bond T3d OH
    1755 CH S Q1b a bond H a bond NH O a bond T3e OH
    1756 CH S Q1b a bond H a bond NH O a bond T3f OH
    1757 CH S Q1b a bond H a bond NH O a bond T3g OH
    1758 CH S Q1b a bond H a bond NH O a bond T3h OH
    1759 CH S Q1b a bond H a bond NH O a bond T3i OH
    1760 CH S Q1b a bond H a bond NH O a bond T3j OH
    1761 CH S Q1c a bond Me a bond NH S NH T3a OH
    1762 CH S Q1c a bond Me a bond NH S NH T3b OH
    1763 CH S Q1c a bond Me a bond NH S NH T3c OH
    1764 CH S Q1c a bond Me a bond NH S NH T3d OH
    1765 CH S Q1c a bond Me a bond NH S NH T3e OH
    1766 CH S Q1c a bond Me a bond NH S NH T3f OH
    1767 CH S Q1c a bond Me a bond NH S NH T3g OH
    1768 CH S Q1c a bond Me a bond NH S NH T3h OH
    1769 CH S Q1c a bond Me a bond NH S NH T3i OH
    1770 CH S Q1c a bond Me a bond NH S NH T3j OH
    1771 CH S Q1c a bond Me a bond NH S a bond T3a OH
    1772 CH S Q1c a bond Me a bond NH S a bond T3b OH
    1773 CH S Q1c a bond Me a bond NH S a bond T3c OH
    1774 CH S Q1c a bond Me a bond NH S a bond T3d OH
    1775 CH S Q1c a bond Me a bond NH S a bond T3e OH
    1776 CH S Q1c a bond Me a bond NH S a bond T3f OH
    1777 CH S Q1c a bond Me a bond NH S a bond T3g OH
    1778 CH S Q1c a bond Me a bond NH S a bond T3h OH
    1779 CH S Q1c a bond Me a bond NH S a bond T3i OH
    1780 CH S Q1c a bond Me a bond NH S a bond T3j OH
    1781 CH S Q1c a bond Me a bond NH O NH T3a OH
    1782 CH S Q1c a bond Me a bond NH O NH T3b OH
    1783 CH S Q1c a bond Me a bond NH O NH T3c OH
    1784 CH S Q1c a bond Me a bond NH O NH T3d OH
    1785 CH S Q1c a bond Me a bond NH O NH T3e OH
    1786 CH S Q1c a bond Me a bond NH O NH T3f OH
    1787 CH S Q1c a bond Me a bond NH O NH T3g OH
    1788 CH S Q1c a bond Me a bond NH O NH T3h OH
    1789 CH S Q1c a bond Me a bond NH O NH T3i OH
    1790 CH S Q1c a bond Me a bond NH O NH T3j OH
    1791 CH S Q1c a bond Me a bond NH O a bond T3a OH
    1792 CH S Q1c a bond Me a bond NH O a bond T3b OH
    1793 CH S Q1c a bond Me a bond NH O a bond T3c OH
    1794 CH S Q1c a bond Me a bond NH O a bond T3d OH
    1795 CH S Q1c a bond Me a bond NH O a bond T3e OH
    1796 CH S Q1c a bond Me a bond NH O a bond T3f OH
    1797 CH S Q1c a bond Me a bond NH O a bond T3g OH
    1798 CH S Q1c a bond Me a bond NH O a bond T3h OH
    1799 CH S Q1c a bond Me a bond NH O a bond T3i OH
    1800 CH S Q1c a bond Me a bond NH O a bond T3j OH
    1801 CH S Q1c a bond H a bond NH S NH T3a OH
    1802 CH S Q1c a bond H a bond NH S NH T3b OH
    1803 CH S Q1c a bond H a bond NH S NH T3c OH
    1804 CH S Q1c a bond H a bond NH S NH T3d OH
    1805 CH S Q1c a bond H a bond NH S NH T3e OH
    1806 CH S Q1c a bond H a bond NH S NH T3f OH
    1807 CH S Q1c a bond H a bond NH S NH T3g OH
    1808 CH S Q1c a bond H a bond NH S NH T3h OH
    1809 CH S Q1c a bond H a bond NH S NH T3i OH
    1810 CH S Q1c a bond H a bond NH S NH T3j OH
    1811 CH S Q1c a bond H a bond NH S a bond T3a OH
    1812 CH S Q1c a bond H a bond NH S a bond T3b OH
    1813 CH S Q1c a bond H a bond NH S a bond T3c OH
    1814 CH S Q1c a bond H a bond NH S a bond T3d OH
    1815 CH S Q1c a bond H a bond NH S a bond T3e OH
    1816 CH S Q1c a bond H a bond NH S a bond T3f OH
    1817 CH S Q1c a bond H a bond NH S a bond T3g OH
    1818 CH S Q1c a bond H a bond NH S a bond T3h OH
    1819 CH S Q1c a bond H a bond NH S a bond T3i OH
    1820 CH S Q1c a bond H a bond NH S a bond T3j OH
    1821 CH S Q1c a bond H a bond NH O NH T3a OH
    1822 CH S Q1c a bond H a bond NH O NH T3b OH
    1823 CH S Q1c a bond H a bond NH O NH T3c OH
    1824 CH S Q1c a bond H a bond NH O NH T3d OH
    1825 CH S Q1c a bond H a bond NH O NH T3e OH
    1826 CH S Q1c a bond H a bond NH O NH T3f OH
    1827 CH S Q1c a bond H a bond NH O NH T3g OH
    1828 CH S Q1c a bond H a bond NH O NH T3h OH
    1829 CH S Q1c a bond H a bond NH O NH T3i OH
    1830 CH S Q1c a bond H a bond NH O NH T3j OH
    1831 CH S Q1c a bond H a bond NH O a bond T3a OH
    1832 CH S Q1c a bond H a bond NH O a bond T3b OH
    1833 CH S Q1c a bond H a bond NH O a bond T3c OH
    1834 CH S Q1c a bond H a bond NH O a bond T3d OH
    1835 CH S Q1c a bond H a bond NH O a bond T3e OH
    1836 CH S Q1c a bond H a bond NH O a bond T3f OH
    1837 CH S Q1c a bond H a bond NH O a bond T3g OH
    1838 CH S Q1c a bond H a bond NH O a bond T3h OH
    1839 CH S Q1c a bond H a bond NH O a bond T3i OH
    1840 CH S Q1c a bond H a bond NH O a bond T3j OH
    1841 CH S Q1i a bond Me a bond NH S NH T3a OH
    1842 CH S Q1i a bond Me a bond NH S NH T3b OH
    1843 CH S Q1i a bond Me a bond NH S NH T3c OH
    1844 CH S Q1i a bond Me a bond NH S NH T3d OH
    1845 CH S Q1i a bond Me a bond NH S NH T3e OH
    1846 CH S Q1i a bond Me a bond NH S NH T3f OH
    1847 CH S Q1i a bond Me a bond NH S NH T3g OH
    1848 CH S Q1i a bond Me a bond NH S NH T3h OH
    1849 CH S Q1i a bond Me a bond NH S NH T3i OH
    1850 CH S Q1i a bond Me a bond NH S NH T3j OH
    1851 CH S Q1i a bond Me a bond NH S a bond T3a OH
    1852 CH S Q1i a bond Me a bond NH S a bond T3b OH
    1853 CH S Q1i a bond Me a bond NH S a bond T3c OH
    1854 CH S Q1i a bond Me a bond NH S a bond T3d OH
    1855 CH S Q1i a bond Me a bond NH S a bond T3e OH
    1856 CH S Q1i a bond Me a bond NH S a bond T3f OH
    1857 CH S Q1i a bond Me a bond NH S a bond T3g OH
    1858 CH S Q1i a bond Me a bond NH S a bond T3h OH
    1859 CH S Q1i a bond Me a bond NH S a bond T3i OH
    1860 CH S Q1i a bond Me a bond NH S a bond T3j OH
    1861 CH S Q1i a bond Me a bond NH O NH T3a OH
    1862 CH S Q1i a bond Me a bond NH O NH T3b OH
    1863 CH S Q1i a bond Me a bond NH O NH T3c OH
    1864 CH S Q1i a bond Me a bond NH O NH T3d OH
    1865 CH S Q1i a bond Me a bond NH O NH T3e OH
    1866 CH S Q1i a bond Me a bond NH O NH T3f OH
    1867 CH S Q1i a bond Me a bond NH O NH T3g OH
    1868 CH S Q1i a bond Me a bond NH O NH T3h OH
    1869 CH S Q1i a bond Me a bond NH O NH T3i OH
    1870 CH S Q1i a bond Me a bond NH O NH T3j OH
    1871 CH S Q1i a bond Me a bond NH O a bond T3a OH
    1872 CH S Q1i a bond Me a bond NH O a bond T3b OH
    1873 CH S Q1i a bond Me a bond NH O a bond T3c OH
    1874 CH S Q1i a bond Me a bond NH O a bond T3d OH
    1875 CH S Q1i a bond Me a bond NH O a bond T3e OH
    1876 CH S Q1i a bond Me a bond NH O a bond T3f OH
    1877 CH S Q1i a bond Me a bond NH O a bond T3g OH
    1878 CH S Q1i a bond Me a bond NH O a bond T3h OH
    1879 CH S Q1i a bond Me a bond NH O a bond T3i OH
    1880 CH S Q1i a bond Me a bond NH O a bond T3j OH
    1881 CH S Q1i a bond H a bond NH S NH T3a OH
    1882 CH S Q1i a bond H a bond NH S NH T3b OH
    1883 CH S Q1i a bond H a bond NH S NH T3c OH
    1884 CH S Q1i a bond H a bond NH S NH T3d OH
    1885 CH S Q1i a bond H a bond NH S NH T3e OH
    1886 CH S Q1i a bond H a bond NH S NH T3f OH
    1887 CH S Q1i a bond H a bond NH S NH T3g OH
    1888 CH S Q1i a bond H a bond NH S NH T3h OH
    1889 CH S Q1i a bond H a bond NH S NH T3i OH
    1890 CH S Q1i a bond H a bond NH S NH T3j OH
    1891 CH S Q1i a bond H a bond NH S a bond T3a OH
    1892 CH S Q1i a bond H a bond NH S a bond T3b OH
    1893 CH S Q1i a bond H a bond NH S a bond T3c OH
    1894 CH S Q1i a bond H a bond NH S a bond T3d OH
    1895 CH S Q1i a bond H a bond NH S a bond T3e OH
    1896 CH S Q1i a bond H a bond NH S a bond T3f OH
    1897 CH S Q1i a bond H a bond NH S a bond T3g OH
    1898 CH S Q1i a bond H a bond NH S a bond T3h OH
    1899 CH S Q1i a bond H a bond NH S a bond T3i OH
    1900 CH S Q1i a bond H a bond NH S a bond T3j OH
    1901 CH S Q1i a bond H a bond NH O NH T3a OH
    1902 CH S Q1i a bond H a bond NH O NH T3b OH
    1903 CH S Q1i a bond H a bond NH O NH T3c OH
    1904 CH S Q1i a bond H a bond NH O NH T3d OH
    1905 CH S Q1i a bond H a bond NH O NH T3e OH
    1906 CH S Q1i a bond H a bond NH O NH T3f OH
    1907 CH S Q1i a bond H a bond NH O NH T3g OH
    1908 CH S Q1i a bond H a bond NH O NH T3h OH
    1909 CH S Q1i a bond H a bond NH O NH T3i OH
    1910 CH S Q1i a bond H a bond NH O NH T3j OH
    1911 CH S Q1i a bond H a bond NH O a bond T3a OH
    1912 CH S Q1i a bond H a bond NH O a bond T3b OH
    1913 CH S Q1i a bond H a bond NH O a bond T3c OH
    1914 CH S Q1i a bond H a bond NH O a bond T3d OH
    1915 CH S Q1i a bond H a bond NH O a bond T3e OH
    1916 CH S Q1i a bond H a bond NH O a bond T3f OH
    1917 CH S Q1i a bond H a bond NH O a bond T3g OH
    1918 CH S Q1i a bond H a bond NH O a bond T3h OH
    1919 CH S Q1i a bond H a bond NH O a bond T3i OH
    1920 CH S Q1i a bond H a bond NH O a bond T3j OH
    1921 CH S Q1j a bond Me a bond NH S NH T3a OH
    1922 CH S Q1j a bond Me a bond NH S NH T3b OH
    1923 CH S Q1j a bond Me a bond NH S NH T3c OH
    1924 CH S Q1j a bond Me a bond NH S NH T3d OH
    1925 CH S Q1j a bond Me a bond NH S NH T3e OH
    1926 CH S Q1j a bond Me a bond NH S NH T3f OH
    1927 CH S Q1j a bond Me a bond NH S NH T3g OH
    1928 CH S Q1j a bond Me a bond NH S NH T3h OH
    1929 CH S Q1j a bond Me a bond NH S NH T3i OH
    1930 CH S Q1j a bond Me a bond NH S NH T3j OH
    1931 CH S Q1j a bond Me a bond NH S a bond T3a OH
    1932 CH S Q1j a bond Me a bond NH S a bond T3b OH
    1933 CH S Q1j a bond Me a bond NH S a bond T3c OH
    1934 CH S Q1j a bond Me a bond NH S a bond T3d OH
    1935 CH S Q1j a bond Me a bond NH S a bond T3e OH
    1936 CH S Q1j a bond Me a bond NH S a bond T3f OH
    1937 CH S Q1j a bond Me a bond NH S a bond T3g OH
    1938 CH S Q1j a bond Me a bond NH S a bond T3h OH
    1939 CH S Q1j a bond Me a bond NH S a bond T3i OH
    1940 CH S Q1j a bond Me a bond NH S a bond T3j OH
    1941 CH S Q1j a bond Me a bond NH O NH T3a OH
    1942 CH S Q1j a bond Me a bond NH O NH T3b OH
    1943 CH S Q1j a bond Me a bond NH O NH T3c OH
    1944 CH S Q1j a bond Me a bond NH O NH T3d OH
    1945 CH S Q1j a bond Me a bond NH O NH T3e OH
    1946 CH S Q1j a bond Me a bond NH O NH T3f OH
    1947 CH S Q1j a bond Me a bond NH O NH T3g OH
    1948 CH S Q1j a bond Me a bond NH O NH T3h OH
    1949 CH S Q1j a bond Me a bond NH O NH T3i OH
    1950 CH S Q1j a bond Me a bond NH O NH T3j OH
    1951 CH S Q1j a bond Me a bond NH O a bond T3a OH
    1952 CH S Q1j a bond Me a bond NH O a bond T3b OH
    1953 CH S Q1j a bond Me a bond NH O a bond T3c OH
    1954 CH S Q1j a bond Me a bond NH O a bond T3d OH
    1955 CH S Q1j a bond Me a bond NH O a bond T3e OH
    1956 CH S Q1j a bond Me a bond NH O a bond T3f OH
    1957 CH S Q1j a bond Me a bond NH O a bond T3g OH
    1958 CH S Q1j a bond Me a bond NH O a bond T3h OH
    1959 CH S Q1j a bond Me a bond NH O a bond T3i OH
    1960 CH S Q1j a bond Me a bond NH O a bond T3j OH
    1961 CH S Q1j a bond H a bond NH S NH T3a OH
    1962 CH S Q1j a bond H a bond NH S NH T3b OH
    1963 CH S Q1j a bond H a bond NH S NH T3c OH
    1964 CH S Q1j a bond H a bond NH S NH T3d OH
    1965 CH S Q1j a bond H a bond NH S NH T3e OH
    1966 CH S Q1j a bond H a bond NH S NH T3f OH
    1967 CH S Q1j a bond H a bond NH S NH T3g OH
    1968 CH S Q1j a bond H a bond NH S NH T3h OH
    1969 CH S Q1j a bond H a bond NH S NH T3i OH
    1970 CH S Q1j a bond H a bond NH S NH T3j OH
    1971 CH S Q1j a bond H a bond NH S a bond T3a OH
    1972 CH S Q1j a bond H a bond NH S a bond T3b OH
    1973 CH S Q1j a bond H a bond NH S a bond T3c OH
    1974 CH S Q1j a bond H a bond NH S a bond T3d OH
    1975 CH S Q1j a bond H a bond NH S a bond T3e OH
    1976 CH S Q1j a bond H a bond NH S a bond T3f OH
    1977 CH S Q1j a bond H a bond NH S a bond T3g OH
    1978 CH S Q1j a bond H a bond NH S a bond T3h OH
    1979 CH S Q1j a bond H a bond NH S a bond T3i OH
    1980 CH S Q1j a bond H a bond NH S a bond T3j OH
    1981 CH S Q1j a bond H a bond NH O NH T3a OH
    1982 CH S Q1j a bond H a bond NH O NH T3b OH
    1983 CH S Q1j a bond H a bond NH O NH T3c OH
    1984 CH S Q1j a bond H a bond NH O NH T3d OH
    1985 CH S Q1j a bond H a bond NH O NH T3e OH
    1986 CH S Q1j a bond H a bond NH O NH T3f OH
    1987 CH S Q1j a bond H a bond NH O NH T3g OH
    1988 CH S Q1j a bond H a bond NH O NH T3h OH
    1989 CH S Q1j a bond H a bond NH O NH T3i OH
    1990 CH S Q1j a bond H a bond NH O NH T3j OH
    1991 CH S Q1j a bond H a bond NH O a bond T3a OH
    1992 CH S Q1j a bond H a bond NH O a bond T3b OH
    1993 CH S Q1j a bond H a bond NH O a bond T3c OH
    1994 CH S Q1j a bond H a bond NH O a bond T3d OH
    1995 CH S Q1j a bond H a bond NH O a bond T3e OH
    1996 CH S Q1j a bond H a bond NH O a bond T3f OH
    1997 CH S Q1j a bond H a bond NH O a bond T3g OH
    1998 CH S Q1j a bond H a bond NH O a bond T3h OH
    1999 CH S Q1j a bond H a bond NH O a bond T3i OH
    2000 CH S Q1j a bond H a bond NH O a bond T3j OH
    2001 CH O Q1a a bond Me a bond NH S NH T3a OH
    2002 CH O Q1a a bond Me a bond NH S NH T3b OH
    2003 CH O Q1a a bond Me a bond NH S NH T3c OH
    2004 CH O Q1a a bond Me a bond NH S NH T3d OH
    2005 CH O Q1a a bond Me a bond NH S NH T3e OH
    2006 CH O Q1a a bond Me a bond NH S NH T3f OH
    2007 CH O Q1a a bond Me a bond NH S NH T3g OH
    2008 CH O Q1a a bond Me a bond NH S NH T3h OH
    2009 CH O Q1a a bond Me a bond NH S NH T3i OH
    2010 CH O Q1a a bond Me a bond NH S NH T3j OH
    2011 CH O Q1a a bond Me a bond NH S a bond T3a OH
    2012 CH O Q1a a bond Me a bond NH S a bond T3b OH
    2013 CH O Q1a a bond Me a bond NH S a bond T3c OH
    2014 CH O Q1a a bond Me a bond NH S a bond T3d OH
    2015 CH O Q1a a bond Me a bond NH S a bond T3e OH
    2016 CH O Q1a a bond Me a bond NH S a bond T3f OH
    2017 CH O Q1a a bond Me a bond NH S a bond T3g OH
    2018 CH O Q1a a bond Me a bond NH S a bond T3h OH
    2019 CH O Q1a a bond Me a bond NH S a bond T3i OH
    2020 CH O Q1a a bond Me a bond NH S a bond T3j OH
    2021 CH O Q1a a bond Me a bond NH O NH T3a OH
    2022 CH O Q1a a bond Me a bond NH O NH T3b OH
    2023 CH O Q1a a bond Me a bond NH O NH T3c OH
    2024 CH O Q1a a bond Me a bond NH O NH T3d OH
    2025 CH O Q1a a bond Me a bond NH O NH T3e OH
    2026 CH O Q1a a bond Me a bond NH O NH T3f OH
    2027 CH O Q1a a bond Me a bond NH O NH T3g OH
    2028 CH O Q1a a bond Me a bond NH O NH T3h OH
    2029 CH O Q1a a bond Me a bond NH O NH T3i OH
    2030 CH O Q1a a bond Me a bond NH O NH T3j OH
    2031 CH O Q1a a bond Me a bond NH O a bond T3a OH
    2032 CH O Q1a a bond Me a bond NH O a bond T3b OH
    2033 CH O Q1a a bond Me a bond NH O a bond T3c OH
    2034 CH O Q1a a bond Me a bond NH O a bond T3d OH
    2035 CH O Q1a a bond Me a bond NH O a bond T3e OH
    2036 CH O Q1a a bond Me a bond NH O a bond T3f OH
    2037 CH O Q1a a bond Me a bond NH O a bond T3g OH
    2038 CH O Q1a a bond Me a bond NH O a bond T3h OH
    2039 CH O Q1a a bond Me a bond NH O a bond T3i OH
    2040 CH O Q1a a bond Me a bond NH O a bond T3j OH
    2041 CH O Q1a a bond H a bond NH S NH T3a OH
    2042 CH O Q1a a bond H a bond NH S NH T3b OH
    2043 CH O Q1a a bond H a bond NH S NH T3c OH
    2044 CH O Q1a a bond H a bond NH S NH T3d OH
    2045 CH O Q1a a bond H a bond NH S NH T3e OH
    2046 CH O Q1a a bond H a bond NH S NH T3f OH
    2047 CH O Q1a a bond H a bond NH S NH T3g OH
    2048 CH O Q1a a bond H a bond NH S NH T3h OH
    2049 CH O Q1a a bond H a bond NH S NH T3i OH
    2050 CH O Q1a a bond H a bond NH S NH T3j OH
    2051 CH O Q1a a bond H a bond NH S a bond T3a OH
    2052 CH O Q1a a bond H a bond NH S a bond T3b OH
    2053 CH O Q1a a bond H a bond NH S a bond T3c OH
    2054 CH O Q1a a bond H a bond NH S a bond T3d OH
    2055 CH O Q1a a bond H a bond NH S a bond T3e OH
    2056 CH O Q1a a bond H a bond NH S a bond T3f OH
    2057 CH O Q1a a bond H a bond NH S a bond T3g OH
    2058 CH O Q1a a bond H a bond NH S a bond T3h OH
    2059 CH O Q1a a bond H a bond NH S a bond T3i OH
    2060 CH O Q1a a bond H a bond NH S a bond T3j OH
    2061 CH O Q1a a bond H a bond NH O NH T3a OH
    2062 CH O Q1a a bond H a bond NH O NH T3b OH
    2063 CH O Q1a a bond H a bond NH O NH T3c OH
    2064 CH O Q1a a bond H a bond NH O NH T3d OH
    2065 CH O Q1a a bond H a bond NH O NH T3e OH
    2066 CH O Q1a a bond H a bond NH O NH T3f OH
    2067 CH O Q1a a bond H a bond NH O NH T3g OH
    2068 CH O Q1a a bond H a bond NH O NH T3h OH
    2069 CH O Q1a a bond H a bond NH O NH T3i OH
    2070 CH O Q1a a bond H a bond NH O NH T3j OH
    2071 CH O Q1a a bond H a bond NH O a bond T3a OH
    2072 CH O Q1a a bond H a bond NH O a bond T3b OH
    2073 CH O Q1a a bond H a bond NH O a bond T3c OH
    2074 CH O Q1a a bond H a bond NH O a bond T3d OH
    2075 CH O Q1a a bond H a bond NH O a bond T3e OH
    2076 CH O Q1a a bond H a bond NH O a bond T3f OH
    2077 CH O Q1a a bond H a bond NH O a bond T3g OH
    2078 CH O Q1a a bond H a bond NH O a bond T3h OH
    2079 CH O Q1a a bond H a bond NH O a bond T3i OH
    2080 CH O Q1a a bond H a bond NH O a bond T3j OH
    2081 CH O Q1b a bond Me a bond NH S NH T3a OH
    2082 CH O Q1b a bond Me a bond NH S NH T3b OH
    2083 CH O Q1b a bond Me a bond NH S NH T3c OH
    2084 CH O Q1b a bond Me a bond NH S NH T3d OH
    2085 CH O Q1b a bond Me a bond NH S NH T3e OH
    2086 CH O Q1b a bond Me a bond NH S NH T3f OH
    2087 CH O Q1b a bond Me a bond NH S NH T3g OH
    2088 CH O Q1b a bond Me a bond NH S NH T3h OH
    2089 CH O Q1b a bond Me a bond NH S NH T3i OH
    2090 CH O Q1b a bond Me a bond NH S NH T3j OH
    2091 CH O Q1b a bond Me a bond NH S a bond T3a OH
    2092 CH O Q1b a bond Me a bond NH S a bond T3b OH
    2093 CH O Q1b a bond Me a bond NH S a bond T3c OH
    2094 CH O Q1b a bond Me a bond NH S a bond T3d OH
    2095 CH O Q1b a bond Me a bond NH S a bond T3e OH
    2096 CH O Q1b a bond Me a bond NH S a bond T3f OH
    2097 CH O Q1b a bond Me a bond NH S a bond T3g OH
    2098 CH O Q1b a bond Me a bond NH S a bond T3h OH
    2099 CH O Q1b a bond Me a bond NH S a bond T3i OH
    2100 CH O Q1b a bond Me a bond NH S a bond T3j OH
    2101 CH O Q1b a bond Me a bond NH O NH T3a OH
    2102 CH O Q1b a bond Me a bond NH O NH T3b OH
    2103 CH O Q1b a bond Me a bond NH O NH T3c OH
    2104 CH O Q1b a bond Me a bond NH O NH T3d OH
    2105 CH O Q1b a bond Me a bond NH O NH T3e OH
    2106 CH O Q1b a bond Me a bond NH O NH T3f OH
    2107 CH O Q1b a bond Me a bond NH O NH T3g OH
    2108 CH O Q1b a bond Me a bond NH O NH T3h OH
    2109 CH O Q1b a bond Me a bond NH O NH T3i OH
    2110 CH O Q1b a bond Me a bond NH O NH T3j OH
    2111 CH O Q1b a bond Me a bond NH O a bond T3a OH
    2112 CH O Q1b a bond Me a bond NH O a bond T3b OH
    2113 CH O Q1b a bond Me a bond NH O a bond T3c OH
    2114 CH O Q1b a bond Me a bond NH O a bond T3d OH
    2115 CH O Q1b a bond Me a bond NH O a bond T3e OH
    2116 CH O Q1b a bond Me a bond NH O a bond T3f OH
    2117 CH O Q1b a bond Me a bond NH O a bond T3g OH
    2118 CH O Q1b a bond Me a bond NH O a bond T3h OH
    2119 CH O Q1b a bond Me a bond NH O a bond T3i OH
    2120 CH O Q1b a bond Me a bond NH O a bond T3j OH
    2121 CH O Q1b a bond H a bond NH S NH T3a OH
    2122 CH O Q1b a bond H a bond NH S NH T3b OH
    2123 CH O Q1b a bond H a bond NH S NH T3c OH
    2124 CH O Q1b a bond H a bond NH S NH T3d OH
    2125 CH O Q1b a bond H a bond NH S NH T3e OH
    2126 CH O Q1b a bond H a bond NH S NH T3f OH
    2127 CH O Q1b a bond H a bond NH S NH T3g OH
    2128 CH O Q1b a bond H a bond NH S NH T3h OH
    2129 CH O Q1b a bond H a bond NH S NH T3i OH
    2130 CH O Q1b a bond H a bond NH S NH T3j OH
    2131 CH O Q1b a bond H a bond NH S a bond T3a OH
    2132 CH O Q1b a bond H a bond NH S a bond T3b OH
    2133 CH O Q1b a bond H a bond NH S a bond T3c OH
    2134 CH O Q1b a bond H a bond NH S a bond T3d OH
    2135 CH O Q1b a bond H a bond NH S a bond T3e OH
    2136 CH O Q1b a bond H a bond NH S a bond T3f OH
    2137 CH O Q1b a bond H a bond NH S a bond T3g OH
    2138 CH O Q1b a bond H a bond NH S a bond T3h OH
    2139 CH O Q1b a bond H a bond NH S a bond T3i OH
    2140 CH O Q1b a bond H a bond NH S a bond T3j OH
    2141 CH O Q1b a bond H a bond NH O NH T3a OH
    2142 CH O Q1b a bond H a bond NH O NH T3b OH
    2143 CH O Q1b a bond H a bond NH O NH T3c OH
    2144 CH O Q1b a bond H a bond NH O NH T3d OH
    2145 CH O Q1b a bond H a bond NH O NH T3e OH
    2146 CH O Q1b a bond H a bond NH O NH T3f OH
    2147 CH O Q1b a bond H a bond NH O NH T3g OH
    2148 CH O Q1b a bond H a bond NH O NH T3h OH
    2149 CH O Q1b a bond H a bond NH O NH T3i OH
    2150 CH O Q1b a bond H a bond NH O NH T3j OH
    2151 CH O Q1b a bond H a bond NH O a bond T3a OH
    2152 CH O Q1b a bond H a bond NH O a bond T3b OH
    2153 CH O Q1b a bond H a bond NH O a bond T3c OH
    2154 CH O Q1b a bond H a bond NH O a bond T3d OH
    2155 CH O Q1b a bond H a bond NH O a bond T3e OH
    2156 CH O Q1b a bond H a bond NH O a bond T3f OH
    2157 CH O Q1b a bond H a bond NH O a bond T3g OH
    2158 CH O Q1b a bond H a bond NH O a bond T3h OH
    2159 CH O Q1b a bond H a bond NH O a bond T3i OH
    2160 CH O Q1b a bond H a bond NH O a bond T3j OH
    2161 CH O Q1c a bond Me a bond NH S NH T3a OH
    2162 CH O Q1c a bond Me a bond NH S NH T3b OH
    2163 CH O Q1c a bond Me a bond NH S NH T3c OH
    2164 CH O Q1c a bond Me a bond NH S NH T3d OH
    2165 CH O Q1c a bond Me a bond NH S NH T3e OH
    2166 CH O Q1c a bond Me a bond NH S NH T3f OH
    2167 CH O Q1c a bond Me a bond NH S NH T3g OH
    2168 CH O Q1c a bond Me a bond NH S NH T3h OH
    2169 CH O Q1c a bond Me a bond NH S NH T3i OH
    2170 CH O Q1c a bond Me a bond NH S NH T3j OH
    2171 CH O Q1c a bond Me a bond NH S a bond T3a OH
    2172 CH O Q1c a bond Me a bond NH S a bond T3b OH
    2173 CH O Q1c a bond Me a bond NH S a bond T3c OH
    2174 CH O Q1c a bond Me a bond NH S a bond T3d OH
    2175 CH O Q1c a bond Me a bond NH S a bond T3e OH
    2176 CH O Q1c a bond Me a bond NH S a bond T3f OH
    2177 CH O Q1c a bond Me a bond NH S a bond T3g OH
    2178 CH O Q1c a bond Me a bond NH S a bond T3h OH
    2179 CH O Q1c a bond Me a bond NH S a bond T3i OH
    2180 CH O Q1c a bond Me a bond NH S a bond T3j OH
    2181 CH O Q1c a bond Me a bond NH O NH T3a OH
    2182 CH O Q1c a bond Me a bond NH O NH T3b OH
    2183 CH O Q1c a bond Me a bond NH O NH T3c OH
    2184 CH O Q1c a bond Me a bond NH O NH T3d OH
    2185 CH O Q1c a bond Me a bond NH O NH T3e OH
    2186 CH O Q1c a bond Me a bond NH O NH T3f OH
    2187 CH O Q1c a bond Me a bond NH O NH T3g OH
    2188 CH O Q1c a bond Me a bond NH O NH T3h OH
    2189 CH O Q1c a bond Me a bond NH O NH T3i OH
    2190 CH O Q1c a bond Me a bond NH O NH T3j OH
    2191 CH O Q1c a bond Me a bond NH O a bond T3a OH
    2192 CH O Q1c a bond Me a bond NH O a bond T3b OH
    2193 CH O Q1c a bond Me a bond NH O a bond T3c OH
    2194 CH O Q1c a bond Me a bond NH O a bond T3d OH
    2195 CH O Q1c a bond Me a bond NH O a bond T3e OH
    2196 CH O Q1c a bond Me a bond NH O a bond T3f OH
    2197 CH O Q1c a bond Me a bond NH O a bond T3g OH
    2198 CH O Q1c a bond Me a bond NH O a bond T3h OH
    2199 CH O Q1c a bond Me a bond NH O a bond T3i OH
    2200 CH O Q1c a bond Me a bond NH O a bond T3j OH
    2201 CH O Q1c a bond H a bond NH S NH T3a OH
    2202 CH O Q1c a bond H a bond NH S NH T3b OH
    2203 CH O Q1c a bond H a bond NH S NH T3c OH
    2204 CH O Q1c a bond H a bond NH S NH T3d OH
    2205 CH O Q1c a bond H a bond NH S NH T3e OH
    2206 CH O Q1c a bond H a bond NH S NH T3f OH
    2207 CH O Q1c a bond H a bond NH S NH T3g OH
    2208 CH O Q1c a bond H a bond NH S NH T3h OH
    2209 CH O Q1c a bond H a bond NH S NH T3i OH
    2210 CH O Q1c a bond H a bond NH S NH T3j OH
    2211 CH O Q1c a bond H a bond NH S a bond T3a OH
    2212 CH O Q1c a bond H a bond NH S a bond T3b OH
    2213 CH O Q1c a bond H a bond NH S a bond T3c OH
    2214 CH O Q1c a bond H a bond NH S a bond T3d OH
    2215 CH O Q1c a bond H a bond NH S a bond T3e OH
    2216 CH O Q1c a bond H a bond NH S a bond T3f OH
    2217 CH O Q1c a bond H a bond NH S a bond T3g OH
    2218 CH O Q1c a bond H a bond NH S a bond T3h OH
    2219 CH O Q1c a bond H a bond NH S a bond T3i OH
    2220 CH O Q1c a bond H a bond NH S a bond T3j OH
    2221 CH O Q1c a bond H a bond NH O NH T3a OH
    2222 CH O Q1c a bond H a bond NH O NH T3b OH
    2223 CH O Q1c a bond H a bond NH O NH T3c OH
    2224 CH O Q1c a bond H a bond NH O NH T3d OH
    2225 CH O Q1c a bond H a bond NH O NH T3e OH
    2226 CH O Q1c a bond H a bond NH O NH T3f OH
    2227 CH O Q1c a bond H a bond NH O NH T3g OH
    2228 CH O Q1c a bond H a bond NH O NH T3h OH
    2229 CH O Q1c a bond H a bond NH O NH T3i OH
    2230 CH O Q1c a bond H a bond NH O NH T3j OH
    2231 CH O Q1c a bond H a bond NH O a bond T3a OH
    2232 CH O Q1c a bond H a bond NH O a bond T3b OH
    2233 CH O Q1c a bond H a bond NH O a bond T3c OH
    2234 CH O Q1c a bond H a bond NH O a bond T3d OH
    2235 CH O Q1c a bond H a bond NH O a bond T3e OH
    2236 CH O Q1c a bond H a bond NH O a bond T3f OH
    2237 CH O Q1c a bond H a bond NH O a bond T3g OH
    2238 CH O Q1c a bond H a bond NH O a bond T3h OH
    2239 CH O Q1c a bond H a bond NH O a bond T3i OH
    2240 CH O Q1c a bond H a bond NH O a bond T3j OH
    2241 CH O Q1i a bond Me a bond NH S NH T3a OH
    2242 CH O Q1i a bond Me a bond NH S NH T3b OH
    2243 CH O Q1i a bond Me a bond NH S NH T3c OH
    2244 CH O Q1i a bond Me a bond NH S NH T3d OH
    2245 CH O Q1i a bond Me a bond NH S NH T3e OH
    2246 CH O Q1i a bond Me a bond NH S NH T3f OH
    2247 CH O Q1i a bond Me a bond NH S NH T3g OH
    2248 CH O Q1i a bond Me a bond NH S NH T3h OH
    2249 CH O Q1i a bond Me a bond NH S NH T3i OH
    2250 CH O Q1i a bond Me a bond NH S NH T3j OH
    2251 CH O Q1i a bond Me a bond NH S a bond T3a OH
    2252 CH O Q1i a bond Me a bond NH S a bond T3b OH
    2253 CH O Q1i a bond Me a bond NH S a bond T3c OH
    2254 CH O Q1i a bond Me a bond NH S a bond T3d OH
    2255 CH O Q1i a bond Me a bond NH S a bond T3e OH
    2256 CH O Q1i a bond Me a bond NH S a bond T3f OH
    2257 CH O Q1i a bond Me a bond NH S a bond T3g OH
    2258 CH O Q1i a bond Me a bond NH S a bond T3h OH
    2259 CH O Q1i a bond Me a bond NH S a bond T3i OH
    2260 CH O Q1i a bond Me a bond NH S a bond T3j OH
    2261 CH O Q1i a bond Me a bond NH O NH T3a OH
    2262 CH O Q1i a bond Me a bond NH O NH T3b OH
    2263 CH O Q1i a bond Me a bond NH O NH T3c OH
    2264 CH O Q1i a bond Me a bond NH O NH T3d OH
    2265 CH O Q1i a bond Me a bond NH O NH T3e OH
    2266 CH O Q1i a bond Me a bond NH O NH T3f OH
    2267 CH O Q1i a bond Me a bond NH O NH T3g OH
    2268 CH O Q1i a bond Me a bond NH O NH T3h OH
    2269 CH O Q1i a bond Me a bond NH O NH T3i OH
    2270 CH O Q1i a bond Me a bond NH O NH T3j OH
    2271 CH O Q1i a bond Me a bond NH O a bond T3a OH
    2272 CH O Q1i a bond Me a bond NH O a bond T3b OH
    2273 CH O Q1i a bond Me a bond NH O a bond T3c OH
    2274 CH O Q1i a bond Me a bond NH O a bond T3d OH
    2275 CH O Q1i a bond Me a bond NH O a bond T3e OH
    2276 CH O Q1i a bond Me a bond NH O a bond T3f OH
    2277 CH O Q1i a bond Me a bond NH O a bond T3g OH
    2278 CH O Q1i a bond Me a bond NH O a bond T3h OH
    2279 CH O Q1i a bond Me a bond NH O a bond T3i OH
    2280 CH O Q1i a bond Me a bond NH O a bond T3j OH
    2281 CH O Q1i a bond H a bond NH S NH T3a OH
    2282 CH O Q1i a bond H a bond NH S NH T3b OH
    2283 CH O Q1i a bond H a bond NH S NH T3c OH
    2284 CH O Q1i a bond H a bond NH S NH T3d OH
    2285 CH O Q1i a bond H a bond NH S NH T3e OH
    2286 CH O Q1i a bond H a bond NH S NH T3f OH
    2287 CH O Q1i a bond H a bond NH S NH T3g OH
    2288 CH O Q1i a bond H a bond NH S NH T3h OH
    2289 CH O Q1i a bond H a bond NH S NH T3i OH
    2290 CH O Q1i a bond H a bond NH S NH T3j OH
    2291 CH O Q1i a bond H a bond NH S a bond T3a OH
    2292 CH O Q1i a bond H a bond NH S a bond T3b OH
    2293 CH O Q1i a bond H a bond NH S a bond T3c OH
    2294 CH O Q1i a bond H a bond NH S a bond T3d OH
    2295 CH O Q1i a bond H a bond NH S a bond T3e OH
    2296 CH O Q1i a bond H a bond NH S a bond T3f OH
    2297 CH O Q1i a bond H a bond NH S a bond T3g OH
    2298 CH O Q1i a bond H a bond NH S a bond T3h OH
    2299 CH O Q1i a bond H a bond NH S a bond T3i OH
    2300 CH O Q1i a bond H a bond NH S a bond T3j OH
    2301 CH O Q1i a bond H a bond NH O NH T3a OH
    2302 CH O Q1i a bond H a bond NH O NH T3b OH
    2303 CH O Q1i a bond H a bond NH O NH T3c OH
    2304 CH O Q1i a bond H a bond NH O NH T3d OH
    2305 CH O Q1i a bond H a bond NH O NH T3e OH
    2306 CH O Q1i a bond H a bond NH O NH T3f OH
    2307 CH O Q1i a bond H a bond NH O NH T3g OH
    2308 CH O Q1i a bond H a bond NH O NH T3h OH
    2309 CH O Q1i a bond H a bond NH O NH T3i OH
    2310 CH O Q1i a bond H a bond NH O NH T3j OH
    2311 CH O Q1i a bond H a bond NH O a bond T3a OH
    2312 CH O Q1i a bond H a bond NH O a bond T3b OH
    2313 CH O Q1i a bond H a bond NH O a bond T3c OH
    2314 CH O Q1i a bond H a bond NH O a bond T3d OH
    2315 CH O Q1i a bond H a bond NH O a bond T3e OH
    2316 CH O Q1i a bond H a bond NH O a bond T3f OH
    2317 CH O Q1i a bond H a bond NH O a bond T3g OH
    2318 CH O Q1i a bond H a bond NH O a bond T3h OH
    2319 CH O Q1i a bond H a bond NH O a bond T3i OH
    2320 CH O Q1i a bond H a bond NH O a bond T3j OH
    2321 CH O Q1j a bond Me a bond NH S NH T3a OH
    2322 CH O Q1j a bond Me a bond NH S NH T3b OH
    2323 CH O Q1j a bond Me a bond NH S NH T3c OH
    2324 CH O Q1j a bond Me a bond NH S NH T3d OH
    2325 CH O Q1j a bond Me a bond NH S NH T3e OH
    2326 CH O Q1j a bond Me a bond NH S NH T3f OH
    2327 CH O Q1j a bond Me a bond NH S NH T3g OH
    2328 CH O Q1j a bond Me a bond NH S NH T3h OH
    2329 CH O Q1j a bond Me a bond NH S NH T3i OH
    2330 CH O Q1j a bond Me a bond NH S NH T3j OH
    2331 CH O Q1j a bond Me a bond NH S a bond T3a OH
    2332 CH O Q1j a bond Me a bond NH S a bond T3b OH
    2333 CH O Q1j a bond Me a bond NH S a bond T3c OH
    2334 CH O Q1j a bond Me a bond NH S a bond T3d OH
    2335 CH O Q1j a bond Me a bond NH S a bond T3e OH
    2336 CH O Q1j a bond Me a bond NH S a bond T3f OH
    2337 CH O Q1j a bond Me a bond NH S a bond T3g OH
    2338 CH O Q1j a bond Me a bond NH S a bond T3h OH
    2339 CH O Q1j a bond Me a bond NH S a bond T3i OH
    2340 CH O Q1j a bond Me a bond NH S a bond T3j OH
    2341 CH O Q1j a bond Me a bond NH O NH T3a OH
    2342 CH O Q1j a bond Me a bond NH O NH T3b OH
    2343 CH O Q1j a bond Me a bond NH O NH T3c OH
    2344 CH O Q1j a bond Me a bond NH O NH T3d OH
    2345 CH O Q1j a bond Me a bond NH O NH T3e OH
    2346 CH O Q1j a bond Me a bond NH O NH T3f OH
    2347 CH O Q1j a bond Me a bond NH O NH T3g OH
    2348 CH O Q1j a bond Me a bond NH O NH T3h OH
    2349 CH O Q1j a bond Me a bond NH O NH T3i OH
    2350 CH O Q1j a bond Me a bond NH O NH T3j OH
    2351 CH O Q1j a bond Me a bond NH O a bond T3a OH
    2352 CH O Q1j a bond Me a bond NH O a bond T3b OH
    2353 CH O Q1j a bond Me a bond NH O a bond T3c OH
    2354 CH O Q1j a bond Me a bond NH O a bond T3d OH
    2355 CH O Q1j a bond Me a bond NH O a bond T3e OH
    2356 CH O Q1j a bond Me a bond NH O a bond T3f OH
    2357 CH O Q1j a bond Me a bond NH O a bond T3g OH
    2358 CH O Q1j a bond Me a bond NH O a bond T3h OH
    2359 CH O Q1j a bond Me a bond NH O a bond T3i OH
    2360 CH O Q1j a bond Me a bond NH O a bond T3j OH
    2361 CH O Q1j a bond H a bond NH S NH T3a OH
    2362 CH O Q1j a bond H a bond NH S NH T3b OH
    2363 CH O Q1j a bond H a bond NH S NH T3c OH
    2364 CH O Q1j a bond H a bond NH S NH T3d OH
    2365 CH O Q1j a bond H a bond NH S NH T3e OH
    2366 CH O Q1j a bond H a bond NH S NH T3f OH
    2367 CH O Q1j a bond H a bond NH S NH T3g OH
    2368 CH O Q1j a bond H a bond NH S NH T3h OH
    2369 CH O Q1j a bond H a bond NH S NH T3i OH
    2370 CH O Q1j a bond H a bond NH S NH T3j OH
    2371 CH O Q1j a bond H a bond NH S a bond T3a OH
    2372 CH O Q1j a bond H a bond NH S a bond T3b OH
    2373 CH O Q1j a bond H a bond NH S a bond T3c OH
    2374 CH O Q1j a bond H a bond NH S a bond T3d OH
    2375 CH O Q1j a bond H a bond NH S a bond T3e OH
    2376 CH O Q1j a bond H a bond NH S a bond T3f OH
    2377 CH O Q1j a bond H a bond NH S a bond T3g OH
    2378 CH O Q1j a bond H a bond NH S a bond T3h OH
    2379 CH O Q1j a bond H a bond NH S a bond T3i OH
    2380 CH O Q1j a bond H a bond NH S a bond T3j OH
    2381 CH O Q1j a bond H a bond NH O NH T3a OH
    2382 CH O Q1j a bond H a bond NH O NH T3b OH
    2383 CH O Q1j a bond H a bond NH O NH T3c OH
    2384 CH O Q1j a bond H a bond NH O NH T3d OH
    2385 CH O Q1j a bond H a bond NH O NH T3e OH
    2386 CH O Q1j a bond H a bond NH O NH T3f OH
    2387 CH O Q1j a bond H a bond NH O NH T3g OH
    2388 CH O Q1j a bond H a bond NH O NH T3h OH
    2389 CH O Q1j a bond H a bond NH O NH T3i OH
    2390 CH O Q1j a bond H a bond NH O NH T3j OH
    2391 CH O Q1j a bond H a bond NH O a bond T3a OH
    2392 CH O Q1j a bond H a bond NH O a bond T3b OH
    2393 CH O Q1j a bond H a bond NH O a bond T3c OH
    2394 CH O Q1j a bond H a bond NH O a bond T3d OH
    2395 CH O Q1j a bond H a bond NH O a bond T3e OH
    2396 CH O Q1j a bond H a bond NH O a bond T3f OH
    2397 CH O Q1j a bond H a bond NH O a bond T3g OH
    2398 CH O Q1j a bond H a bond NH O a bond T3h OH
    2399 CH O Q1j a bond H a bond NH O a bond T3i OH
    2400 CH O Q1j a bond H a bond NH O a bond T3j OH
    2401 CMe NMe Q1a a bond Me a bond NH S NH T3a OH
    2402 CMe NMe Q1a a bond Me a bond NH S NH T3b OH
    2403 CMe NMe Q1a a bond Me a bond NH S NH T3c OH
    2404 CMe NMe Q1a a bond Me a bond NH S NH T3d OH
    2405 CMe NMe Q1a a bond Me a bond NH S NH T3e OH
    2406 CMe NMe Q1a a bond Me a bond NH S NH T3f OH
    2407 CMe NMe Q1a a bond Me a bond NH S NH T3g OH
    2408 CMe NMe Q1a a bond Me a bond NH S NH T3h OH
    2409 CMe NMe Q1a a bond Me a bond NH S NH T3i OH
    2410 CMe NMe Q1a a bond Me a bond NH S NH T3j OH
    2411 CMe NMe Q1a a bond Me a bond NH S a bond T3a OH
    2412 CMe NMe Q1a a bond Me a bond NH S a bond T3b OH
    2413 CMe NMe Q1a a bond Me a bond NH S a bond T3c OH
    2414 CMe NMe Q1a a bond Me a bond NH S a bond T3d OH
    2415 CMe NMe Q1a a bond Me a bond NH S a bond T3e OH
    2416 CMe NMe Q1a a bond Me a bond NH S a bond T3f OH
    2417 CMe NMe Q1a a bond Me a bond NH S a bond T3g OH
    2418 CMe NMe Q1a a bond Me a bond NH S a bond T3h OH
    2419 CMe NMe Q1a a bond Me a bond NH S a bond T3i OH
    2420 CMe NMe Q1a a bond Me a bond NH S a bond T3j OH
    2421 CMe NMe Q1a a bond Me a bond NH O NH T3a OH
    2422 CMe NMe Q1a a bond Me a bond NH O NH T3b OH
    2423 CMe NMe Q1a a bond Me a bond NH O NH T3c OH
    2424 CMe NMe Q1a a bond Me a bond NH O NH T3d OH
    2425 CMe NMe Q1a a bond Me a bond NH O NH T3e OH
    2426 CMe NMe Q1a a bond Me a bond NH O NH T3f OH
    2427 CMe NMe Q1a a bond Me a bond NH O NH T3g OH
    2428 CMe NMe Q1a a bond Me a bond NH O NH T3h OH
    2429 CMe NMe Q1a a bond Me a bond NH O NH T3i OH
    2430 CMe NMe Q1a a bond Me a bond NH O NH T3j OH
    2431 CMe NMe Q1a a bond Me a bond NH O a bond T3a OH
    2432 CMe NMe Q1a a bond Me a bond NH O a bond T3b OH
    2433 CMe NMe Q1a a bond Me a bond NH O a bond T3c OH
    2434 CMe NMe Q1a a bond Me a bond NH O a bond T3d OH
    2435 CMe NMe Q1a a bond Me a bond NH O a bond T3e OH
    2436 CMe NMe Q1a a bond Me a bond NH O a bond T3f OH
    2437 CMe NMe Q1a a bond Me a bond NH O a bond T3g OH
    2438 CMe NMe Q1a a bond Me a bond NH O a bond T3h OH
    2439 CMe NMe Q1a a bond Me a bond NH O a bond T3i OH
    2440 CMe NMe Q1a a bond Me a bond NH O a bond T3j OH
    2441 CMe NMe Q1a a bond H a bond NH S NH T3a OH
    2442 CMe NMe Q1a a bond H a bond NH S NH T3b OH
    2443 CMe NMe Q1a a bond H a bond NH S NH T3c OH
    2444 CMe NMe Q1a a bond H a bond NH S NH T3d OH
    2445 CMe NMe Q1a a bond H a bond NH S NH T3e OH
    2446 CMe NMe Q1a a bond H a bond NH S NH T3f OH
    2447 CMe NMe Q1a a bond H a bond NH S NH T3g OH
    2448 CMe NMe Q1a a bond H a bond NH S NH T3h OH
    2449 CMe NMe Q1a a bond H a bond NH S NH T3i OH
    2450 CMe NMe Q1a a bond H a bond NH S NH T3j OH
    2451 CMe NMe Q1a a bond H a bond NH S a bond T3a OH
    2452 CMe NMe Q1a a bond H a bond NH S a bond T3b OH
    2453 CMe NMe Q1a a bond H a bond NH S a bond T3c OH
    2454 CMe NMe Q1a a bond H a bond NH S a bond T3d OH
    2455 CMe NMe Q1a a bond H a bond NH S a bond T3e OH
    2456 CMe NMe Q1a a bond H a bond NH S a bond T3f OH
    2457 CMe NMe Q1a a bond H a bond NH S a bond T3g OH
    2458 CMe NMe Q1a a bond H a bond NH S a bond T3h OH
    2459 CMe NMe Q1a a bond H a bond NH S a bond T3i OH
    2460 CMe NMe Q1a a bond H a bond NH S a bond T3j OH
    2461 CMe NMe Q1a a bond H a bond NH O NH T3a OH
    2462 CMe NMe Q1a a bond H a bond NH O NH T3b OH
    2463 CMe NMe Q1a a bond H a bond NH O NH T3c OH
    2464 CMe NMe Q1a a bond H a bond NH O NH T3d OH
    2465 CMe NMe Q1a a bond H a bond NH O NH T3e OH
    2466 CMe NMe Q1a a bond H a bond NH O NH T3f OH
    2467 CMe NMe Q1a a bond H a bond NH O NH T3g OH
    2468 CMe NMe Q1a a bond H a bond NH O NH T3h OH
    2469 CMe NMe Q1a a bond H a bond NH O NH T3i OH
    2470 CMe NMe Q1a a bond H a bond NH O NH T3j OH
    2471 CMe NMe Q1a a bond H a bond NH O a bond T3a OH
    2472 CMe NMe Q1a a bond H a bond NH O a bond T3b OH
    2473 CMe NMe Q1a a bond H a bond NH O a bond T3c OH
    2474 CMe NMe Q1a a bond H a bond NH O a bond T3d OH
    2475 CMe NMe Q1a a bond H a bond NH O a bond T3e OH
    2476 CMe NMe Q1a a bond H a bond NH O a bond T3f OH
    2477 CMe NMe Q1a a bond H a bond NH O a bond T3g OH
    2478 CMe NMe Q1a a bond H a bond NH O a bond T3h OH
    2479 CMe NMe Q1a a bond H a bond NH O a bond T3i OH
    2480 CMe NMe Q1a a bond H a bond NH O a bond T3j OH
    2481 CMe NMe Q1b a bond Me a bond NH S NH T3a OH
    2482 CMe NMe Q1b a bond Me a bond NH S NH T3b OH
    2483 CMe NMe Q1b a bond Me a bond NH S NH T3c OH
    2484 CMe NMe Q1b a bond Me a bond NH S NH T3d OH
    2485 CMe NMe Q1b a bond Me a bond NH S NH T3e OH
    2486 CMe NMe Q1b a bond Me a bond NH S NH T3f OH
    2487 CMe NMe Q1b a bond Me a bond NH S NH T3g OH
    2488 CMe NMe Q1b a bond Me a bond NH S NH T3h OH
    2489 CMe NMe Q1b a bond Me a bond NH S NH T3i OH
    2490 CMe NMe Q1b a bond Me a bond NH S NH T3j OH
    2491 CMe NMe Q1b a bond Me a bond NH S a bond T3a OH
    2492 CMe NMe Q1b a bond Me a bond NH S a bond T3b OH
    2493 CMe NMe Q1b a bond Me a bond NH S a bond T3c OH
    2494 CMe NMe Q1b a bond Me a bond NH S a bond T3d OH
    2495 CMe NMe Q1b a bond Me a bond NH S a bond T3e OH
    2496 CMe NMe Q1b a bond Me a bond NH S a bond T3f OH
    2497 CMe NMe Q1b a bond Me a bond NH S a bond T3g OH
    2498 CMe NMe Q1b a bond Me a bond NH S a bond T3h OH
    2499 CMe NMe Q1b a bond Me a bond NH S a bond T3i OH
    2500 CMe NMe Q1b a bond Me a bond NH S a bond T3j OH
    2501 CMe NMe Q1b a bond Me a bond NH O NH T3a OH
    2502 CMe NMe Q1b a bond Me a bond NH O NH T3b OH
    2503 CMe NMe Q1b a bond Me a bond NH O NH T3c OH
    2504 CMe NMe Q1b a bond Me a bond NH O NH T3d OH
    2505 CMe NMe Q1b a bond Me a bond NH O NH T3e OH
    2506 CMe NMe Q1b a bond Me a bond NH O NH T3f OH
    2507 CMe NMe Q1b a bond Me a bond NH O NH T3g OH
    2508 CMe NMe Q1b a bond Me a bond NH O NH T3h OH
    2509 CMe NMe Q1b a bond Me a bond NH O NH T3i OH
    2510 CMe NMe Q1b a bond Me a bond NH O NH T3j OH
    2511 CMe NMe Q1b a bond Me a bond NH O a bond T3a OH
    2512 CMe NMe Q1b a bond Me a bond NH O a bond T3b OH
    2513 CMe NMe Q1b a bond Me a bond NH O a bond T3c OH
    2514 CMe NMe Q1b a bond Me a bond NH O a bond T3d OH
    2515 CMe NMe Q1b a bond Me a bond NH O a bond T3e OH
    2516 CMe NMe Q1b a bond Me a bond NH O a bond T3f OH
    2517 CMe NMe Q1b a bond Me a bond NH O a bond T3g OH
    2518 CMe NMe Q1b a bond Me a bond NH O a bond T3h OH
    2519 CMe NMe Q1b a bond Me a bond NH O a bond T3i OH
    2520 CMe NMe Q1b a bond Me a bond NH O a bond T3j OH
    2521 CMe NMe Q1b a bond H a bond NH S NH T3a OH
    2522 CMe NMe Q1b a bond H a bond NH S NH T3b OH
    2523 CMe NMe Q1b a bond H a bond NH S NH T3c OH
    2524 CMe NMe Q1b a bond H a bond NH S NH T3d OH
    2525 CMe NMe Q1b a bond H a bond NH S NH T3e OH
    2526 CMe NMe Q1b a bond H a bond NH S NH T3f OH
    2527 CMe NMe Q1b a bond H a bond NH S NH T3g OH
    2528 CMe NMe Q1b a bond H a bond NH S NH T3h OH
    2529 CMe NMe Q1b a bond H a bond NH S NH T3i OH
    2530 CMe NMe Q1b a bond H a bond NH S NH T3j OH
    2531 CMe NMe Q1b a bond H a bond NH S a bond T3a OH
    2532 CMe NMe Q1b a bond H a bond NH S a bond T3b OH
    2533 CMe NMe Q1b a bond H a bond NH S a bond T3c OH
    2534 CMe NMe Q1b a bond H a bond NH S a bond T3d OH
    2535 CMe NMe Q1b a bond H a bond NH S a bond T3e OH
    2536 CMe NMe Q1b a bond H a bond NH S a bond T3f OH
    2537 CMe NMe Q1b a bond H a bond NH S a bond T3g OH
    2538 CMe NMe Q1b a bond H a bond NH S a bond T3h OH
    2539 CMe NMe Q1b a bond H a bond NH S a bond T3i OH
    2540 CMe NMe Q1b a bond H a bond NH S a bond T3j OH
    2541 CMe NMe Q1b a bond H a bond NH O NH T3a OH
    2542 CMe NMe Q1b a bond H a bond NH O NH T3b OH
    2543 CMe NMe Q1b a bond H a bond NH O NH T3c OH
    2544 CMe NMe Q1b a bond H a bond NH O NH T3d OH
    2545 CMe NMe Q1b a bond H a bond NH O NH T3e OH
    2546 CMe NMe Q1b a bond H a bond NH O NH T3f OH
    2547 CMe NMe Q1b a bond H a bond NH O NH T3g OH
    2548 CMe NMe Q1b a bond H a bond NH O NH T3h OH
    2549 CMe NMe Q1b a bond H a bond NH O NH T3i OH
    2550 CMe NMe Q1b a bond H a bond NH O NH T3j OH
    2551 CMe NMe Q1b a bond H a bond NH O a bond T3a OH
    2552 CMe NMe Q1b a bond H a bond NH O a bond T3b OH
    2553 CMe NMe Q1b a bond H a bond NH O a bond T3c OH
    2554 CMe NMe Q1b a bond H a bond NH O a bond T3d OH
    2555 CMe NMe Q1b a bond H a bond NH O a bond T3e OH
    2556 CMe NMe Q1b a bond H a bond NH O a bond T3f OH
    2557 CMe NMe Q1b a bond H a bond NH O a bond T3g OH
    2558 CMe NMe Q1b a bond H a bond NH O a bond T3h OH
    2559 CMe NMe Q1b a bond H a bond NH O a bond T3i OH
    2560 CMe NMe Q1b a bond H a bond NH O a bond T3j OH
    2561 CMe NMe Q1c a bond Me a bond NH S NH T3a OH
    2562 CMe NMe Q1c a bond Me a bond NH S NH T3b OH
    2563 CMe NMe Q1c a bond Me a bond NH S NH T3c OH
    2564 CMe NMe Q1c a bond Me a bond NH S NH T3d OH
    2565 CMe NMe Q1c a bond Me a bond NH S NH T3e OH
    2566 CMe NMe Q1c a bond Me a bond NH S NH T3f OH
    2567 CMe NMe Q1c a bond Me a bond NH S NH T3g OH
    2568 CMe NMe Q1c a bond Me a bond NH S NH T3h OH
    2569 CMe NMe Q1c a bond Me a bond NH S NH T3i OH
    2570 CMe NMe Q1c a bond Me a bond NH S NH T3j OH
    2571 CMe NMe Q1c a bond Me a bond NH S a bond T3a OH
    2572 CMe NMe Q1c a bond Me a bond NH S a bond T3b OH
    2573 CMe NMe Q1c a bond Me a bond NH S a bond T3c OH
    2574 CMe NMe Q1c a bond Me a bond NH S a bond T3d OH
    2575 CMe NMe Q1c a bond Me a bond NH S a bond T3e OH
    2576 CMe NMe Q1c a bond Me a bond NH S a bond T3f OH
    2577 CMe NMe Q1c a bond Me a bond NH S a bond T3g OH
    2578 CMe NMe Q1c a bond Me a bond NH S a bond T3h OH
    2579 CMe NMe Q1c a bond Me a bond NH S a bond T3i OH
    2580 CMe NMe Q1c a bond Me a bond NH S a bond T3j OH
    2581 CMe NMe Q1c a bond Me a bond NH O NH T3a OH
    2582 CMe NMe Q1c a bond Me a bond NH O NH T3b OH
    2583 CMe NMe Q1c a bond Me a bond NH O NH T3c OH
    2584 CMe NMe Q1c a bond Me a bond NH O NH T3d OH
    2585 CMe NMe Q1c a bond Me a bond NH O NH T3e OH
    2586 CMe NMe Q1c a bond Me a bond NH O NH T3f OH
    2587 CMe NMe Q1c a bond Me a bond NH O NH T3g OH
    2588 CMe NMe Q1c a bond Me a bond NH O NH T3h OH
    2589 CMe NMe Q1c a bond Me a bond NH O NH T3i OH
    2590 CMe NMe Q1c a bond Me a bond NH O NH T3j OH
    2591 CMe NMe Q1c a bond Me a bond NH O a bond T3a OH
    2592 CMe NMe Q1c a bond Me a bond NH O a bond T3b OH
    2593 CMe NMe Q1c a bond Me a bond NH O a bond T3c OH
    2594 CMe NMe Q1c a bond Me a bond NH O a bond T3d OH
    2595 CMe NMe Q1c a bond Me a bond NH O a bond T3e OH
    2596 CMe NMe Q1c a bond Me a bond NH O a bond T3f OH
    2597 CMe NMe Q1c a bond Me a bond NH O a bond T3g OH
    2598 CMe NMe Q1c a bond Me a bond NH O a bond T3h OH
    2599 CMe NMe Q1c a bond Me a bond NH O a bond T3i OH
    2600 CMe NMe Q1c a bond Me a bond NH O a bond T3j OH
    2601 CMe NMe Q1c a bond H a bond NH S NH T3a OH
    2602 CMe NMe Q1c a bond H a bond NH S NH T3b OH
    2603 CMe NMe Q1c a bond H a bond NH S NH T3c OH
    2604 CMe NMe Q1c a bond H a bond NH S NH T3d OH
    2605 CMe NMe Q1c a bond H a bond NH S NH T3e OH
    2606 CMe NMe Q1c a bond H a bond NH S NH T3f OH
    2607 CMe NMe Q1c a bond H a bond NH S NH T3g OH
    2608 CMe NMe Q1c a bond H a bond NH S NH T3h OH
    2609 CMe NMe Q1c a bond H a bond NH S NH T3i OH
    2610 CMe NMe Q1c a bond H a bond NH S NH T3j OH
    2611 CMe NMe Q1c a bond H a bond NH S a bond T3a OH
    2612 CMe NMe Q1c a bond H a bond NH S a bond T3b OH
    2613 CMe NMe Q1c a bond H a bond NH S a bond T3c OH
    2614 CMe NMe Q1c a bond H a bond NH S a bond T3d OH
    2615 CMe NMe Q1c a bond H a bond NH S a bond T3e OH
    2616 CMe NMe Q1c a bond H a bond NH S a bond T3f OH
    2617 CMe NMe Q1c a bond H a bond NH S a bond T3g OH
    2618 CMe NMe Q1c a bond H a bond NH S a bond T3h OH
    2619 CMe NMe Q1c a bond H a bond NH S a bond T3i OH
    2620 CMe NMe Q1c a bond H a bond NH S a bond T3j OH
    2621 CMe NMe Q1c a bond H a bond NH O NH T3a OH
    2622 CMe NMe Q1c a bond H a bond NH O NH T3b OH
    2623 CMe NMe Q1c a bond H a bond NH O NH T3c OH
    2624 CMe NMe Q1c a bond H a bond NH O NH T3d OH
    2625 CMe NMe Q1c a bond H a bond NH O NH T3e OH
    2626 CMe NMe Q1c a bond H a bond NH O NH T3f OH
    2627 CMe NMe Q1c a bond H a bond NH O NH T3g OH
    2628 CMe NMe Q1c a bond H a bond NH O NH T3h OH
    2629 CMe NMe Q1c a bond H a bond NH O NH T3i OH
    2630 CMe NMe Q1c a bond H a bond NH O NH T3j OH
    2631 CMe NMe Q1c a bond H a bond NH O a bond T3a OH
    2632 CMe NMe Q1c a bond H a bond NH O a bond T3b OH
    2633 CMe NMe Q1c a bond H a bond NH O a bond T3c OH
    2634 CMe NMe Q1c a bond H a bond NH O a bond T3d OH
    2635 CMe NMe Q1c a bond H a bond NH O a bond T3e OH
    2636 CMe NMe Q1c a bond H a bond NH O a bond T3f OH
    2637 CMe NMe Q1c a bond H a bond NH O a bond T3g OH
    2638 CMe NMe Q1c a bond H a bond NH O a bond T3h OH
    2639 CMe NMe Q1c a bond H a bond NH O a bond T3i OH
    2640 CMe NMe Q1c a bond H a bond NH O a bond T3j OH
    2641 CMe NMe Q1i a bond Me a bond NH S NH T3a OH
    2642 CMe NMe Q1i a bond Me a bond NH S NH T3b OH
    2643 CMe NMe Q1i a bond Me a bond NH S NH T3c OH
    2644 CMe NMe Q1i a bond Me a bond NH S NH T3d OH
    2645 CMe NMe Q1i a bond Me a bond NH S NH T3e OH
    2646 CMe NMe Q1i a bond Me a bond NH S NH T3f OH
    2647 CMe NMe Q1i a bond Me a bond NH S NH T3g OH
    2648 CMe NMe Q1i a bond Me a bond NH S NH T3h OH
    2649 CMe NMe Q1i a bond Me a bond NH S NH T3i OH
    2650 CMe NMe Q1i a bond Me a bond NH S NH T3j OH
    2651 CMe NMe Q1i a bond Me a bond NH S a bond T3a OH
    2652 CMe NMe Q1i a bond Me a bond NH S a bond T3b OH
    2653 CMe NMe Q1i a bond Me a bond NH S a bond T3c OH
    2654 CMe NMe Q1i a bond Me a bond NH S a bond T3d OH
    2655 CMe NMe Q1i a bond Me a bond NH S a bond T3e OH
    2656 CMe NMe Q1i a bond Me a bond NH S a bond T3f OH
    2657 CMe NMe Q1i a bond Me a bond NH S a bond T3g OH
    2658 CMe NMe Q1i a bond Me a bond NH S a bond T3h OH
    2659 CMe NMe Q1i a bond Me a bond NH S a bond T3i OH
    2660 CMe NMe Q1i a bond Me a bond NH S a bond T3j OH
    2661 CMe NMe Q1i a bond Me a bond NH O NH T3a OH
    2662 CMe NMe Q1i a bond Me a bond NH O NH T3b OH
    2663 CMe NMe Q1i a bond Me a bond NH O NH T3c OH
    2664 CMe NMe Q1i a bond Me a bond NH O NH T3d OH
    2665 CMe NMe Q1i a bond Me a bond NH O NH T3e OH
    2666 CMe NMe Q1i a bond Me a bond NH O NH T3f OH
    2667 CMe NMe Q1i a bond Me a bond NH O NH T3g OH
    2668 CMe NMe Q1i a bond Me a bond NH O NH T3h OH
    2669 CMe NMe Q1i a bond Me a bond NH O NH T3i OH
    2670 CMe NMe Q1i a bond Me a bond NH O NH T3j OH
    2671 CMe NMe Q1i a bond Me a bond NH O a bond T3a OH
    2672 CMe NMe Q1i a bond Me a bond NH O a bond T3b OH
    2673 CMe NMe Q1i a bond Me a bond NH O a bond T3c OH
    2674 CMe NMe Q1i a bond Me a bond NH O a bond T3d OH
    2675 CMe NMe Q1i a bond Me a bond NH O a bond T3e OH
    2676 CMe NMe Q1i a bond Me a bond NH O a bond T3f OH
    2677 CMe NMe Q1i a bond Me a bond NH O a bond T3g OH
    2678 CMe NMe Q1i a bond Me a bond NH O a bond T3h OH
    2679 CMe NMe Q1i a bond Me a bond NH O a bond T3i OH
    2680 CMe NMe Q1i a bond Me a bond NH O a bond T3j OH
    2681 CMe NMe Q1i a bond H a bond NH S NH T3a OH
    2682 CMe NMe Q1i a bond H a bond NH S NH T3b OH
    2683 CMe NMe Q1i a bond H a bond NH S NH T3c OH
    2684 CMe NMe Q1i a bond H a bond NH S NH T3d OH
    2685 CMe NMe Q1i a bond H a bond NH S NH T3e OH
    2686 CMe NMe Q1i a bond H a bond NH S NH T3f OH
    2687 CMe NMe Q1i a bond H a bond NH S NH T3g OH
    2688 CMe NMe Q1i a bond H a bond NH S NH T3h OH
    2689 CMe NMe Q1i a bond H a bond NH S NH T3i OH
    2690 CMe NMe Q1i a bond H a bond NH S NH T3j OH
    2691 CMe NMe Q1i a bond H a bond NH S a bond T3a OH
    2692 CMe NMe Q1i a bond H a bond NH S a bond T3b OH
    2693 CMe NMe Q1i a bond H a bond NH S a bond T3c OH
    2694 CMe NMe Q1i a bond H a bond NH S a bond T3d OH
    2695 CMe NMe Q1i a bond H a bond NH S a bond T3e OH
    2696 CMe NMe Q1i a bond H a bond NH S a bond T3f OH
    2697 CMe NMe Q1i a bond H a bond NH S a bond T3g OH
    2698 CMe NMe Q1i a bond H a bond NH S a bond T3h OH
    2699 CMe NMe Q1i a bond H a bond NH S a bond T3i OH
    2700 CMe NMe Q1i a bond H a bond NH S a bond T3j OH
    2701 CMe NMe Q1i a bond H a bond NH O NH T3a OH
    2702 CMe NMe Q1i a bond H a bond NH O NH T3b OH
    2703 CMe NMe Q1i a bond H a bond NH O NH T3c OH
    2704 CMe NMe Q1i a bond H a bond NH O NH T3d OH
    2705 CMe NMe Q1i a bond H a bond NH O NH T3e OH
    2706 CMe NMe Q1i a bond H a bond NH O NH T3f OH
    2707 CMe NMe Q1i a bond H a bond NH O NH T3g OH
    2708 CMe NMe Q1i a bond H a bond NH O NH T3h OH
    2709 CMe NMe Q1i a bond H a bond NH O NH T3i OH
    2710 CMe NMe Q1i a bond H a bond NH O NH T3j OH
    2711 CMe NMe Q1i a bond H a bond NH O a bond T3a OH
    2712 CMe NMe Q1i a bond H a bond NH O a bond T3b OH
    2713 CMe NMe Q1i a bond H a bond NH O a bond T3c OH
    2714 CMe NMe Q1i a bond H a bond NH O a bond T3d OH
    2715 CMe NMe Q1i a bond H a bond NH O a bond T3e OH
    2716 CMe NMe Q1i a bond H a bond NH O a bond T3f OH
    2717 CMe NMe Q1i a bond H a bond NH O a bond T3g OH
    2718 CMe NMe Q1i a bond H a bond NH O a bond T3h OH
    2719 CMe NMe Q1i a bond H a bond NH O a bond T3i OH
    2720 CMe NMe Q1i a bond H a bond NH O a bond T3j OH
    2721 CMe NMe Q1j a bond Me a bond NH S NH T3a OH
    2722 CMe NMe Q1j a bond Me a bond NH S NH T3b OH
    2723 CMe NMe Q1j a bond Me a bond NH S NH T3c OH
    2724 CMe NMe Q1j a bond Me a bond NH S NH T3d OH
    2725 CMe NMe Q1j a bond Me a bond NH S NH T3e OH
    2726 CMe NMe Q1j a bond Me a bond NH S NH T3f OH
    2727 CMe NMe Q1j a bond Me a bond NH S NH T3g OH
    2728 CMe NMe Q1j a bond Me a bond NH S NH T3h OH
    2729 CMe NMe Q1j a bond Me a bond NH S NH T3i OH
    2730 CMe NMe Q1j a bond Me a bond NH S NH T3j OH
    2731 CMe NMe Q1j a bond Me a bond NH S a bond T3a OH
    2732 CMe NMe Q1j a bond Me a bond NH S a bond T3b OH
    2733 CMe NMe Q1j a bond Me a bond NH S a bond T3c OH
    2734 CMe NMe Q1j a bond Me a bond NH S a bond T3d OH
    2735 CMe NMe Q1j a bond Me a bond NH S a bond T3e OH
    2736 CMe NMe Q1j a bond Me a bond NH S a bond T3f OH
    2737 CMe NMe Q1j a bond Me a bond NH S a bond T3g OH
    2738 CMe NMe Q1j a bond Me a bond NH S a bond T3h OH
    2739 CMe NMe Q1j a bond Me a bond NH S a bond T3i OH
    2740 CMe NMe Q1j a bond Me a bond NH S a bond T3j OH
    2741 CMe NMe Q1j a bond Me a bond NH O NH T3a OH
    2742 CMe NMe Q1j a bond Me a bond NH O NH T3b OH
    2743 CMe NMe Q1j a bond Me a bond NH O NH T3c OH
    2744 CMe NMe Q1j a bond Me a bond NH O NH T3d OH
    2745 CMe NMe Q1j a bond Me a bond NH O NH T3e OH
    2746 CMe NMe Q1j a bond Me a bond NH O NH T3f OH
    2747 CMe NMe Q1j a bond Me a bond NH O NH T3g OH
    2748 CMe NMe Q1j a bond Me a bond NH O NH T3h OH
    2749 CMe NMe Q1j a bond Me a bond NH O NH T3i OH
    2750 CMe NMe Q1j a bond Me a bond NH O NH T3j OH
    2751 CMe NMe Q1j a bond Me a bond NH O a bond T3a OH
    2752 CMe NMe Q1j a bond Me a bond NH O a bond T3b OH
    2753 CMe NMe Q1j a bond Me a bond NH O a bond T3c OH
    2754 CMe NMe Q1j a bond Me a bond NH O a bond T3d OH
    2755 CMe NMe Q1j a bond Me a bond NH O a bond T3e OH
    2756 CMe NMe Q1j a bond Me a bond NH O a bond T3f OH
    2757 CMe NMe Q1j a bond Me a bond NH O a bond T3g OH
    2758 CMe NMe Q1j a bond Me a bond NH O a bond T3h OH
    2759 CMe NMe Q1j a bond Me a bond NH O a bond T3i OH
    2760 CMe NMe Q1j a bond Me a bond NH O a bond T3j OH
    2761 CMe NMe Q1j a bond H a bond NH S NH T3a OH
    2762 CMe NMe Q1j a bond H a bond NH S NH T3b OH
    2763 CMe NMe Q1j a bond H a bond NH S NH T3c OH
    2764 CMe NMe Q1j a bond H a bond NH S NH T3d OH
    2765 CMe NMe Q1j a bond H a bond NH S NH T3e OH
    2766 CMe NMe Q1j a bond H a bond NH S NH T3f OH
    2767 CMe NMe Q1j a bond H a bond NH S NH T3g OH
    2768 CMe NMe Q1j a bond H a bond NH S NH T3h OH
    2769 CMe NMe Q1j a bond H a bond NH S NH T3i OH
    2770 CMe NMe Q1j a bond H a bond NH S NH T3j OH
    2771 CMe NMe Q1j a bond H a bond NH S a bond T3a OH
    2772 CMe NMe Q1j a bond H a bond NH S a bond T3b OH
    2773 CMe NMe Q1j a bond H a bond NH S a bond T3c OH
    2774 CMe NMe Q1j a bond H a bond NH S a bond T3d OH
    2775 CMe NMe Q1j a bond H a bond NH S a bond T3e OH
    2776 CMe NMe Q1j a bond H a bond NH S a bond T3f OH
    2777 CMe NMe Q1j a bond H a bond NH S a bond T3g OH
    2778 CMe NMe Q1j a bond H a bond NH S a bond T3h OH
    2779 CMe NMe Q1j a bond H a bond NH S a bond T3i OH
    2780 CMe NMe Q1j a bond H a bond NH S a bond T3j OH
    2781 CMe NMe Q1j a bond H a bond NH O NH T3a OH
    2782 CMe NMe Q1j a bond H a bond NH O NH T3b OH
    2783 CMe NMe Q1j a bond H a bond NH O NH T3c OH
    2784 CMe NMe Q1j a bond H a bond NH O NH T3d OH
    2785 CMe NMe Q1j a bond H a bond NH O NH T3e OH
    2786 CMe NMe Q1j a bond H a bond NH O NH T3f OH
    2787 CMe NMe Q1j a bond H a bond NH O NH T3g OH
    2788 CMe NMe Q1j a bond H a bond NH O NH T3h OH
    2789 CMe NMe Q1j a bond H a bond NH O NH T3i OH
    2790 CMe NMe Q1j a bond H a bond NH O NH T3j OH
    2791 CMe NMe Q1j a bond H a bond NH O a bond T3a OH
    2792 CMe NMe Q1j a bond H a bond NH O a bond T3b OH
    2793 CMe NMe Q1j a bond H a bond NH O a bond T3c OH
    2794 CMe NMe Q1j a bond H a bond NH O a bond T3d OH
    2795 CMe NMe Q1j a bond H a bond NH O a bond T3e OH
    2796 CMe NMe Q1j a bond H a bond NH O a bond T3f OH
    2797 CMe NMe Q1j a bond H a bond NH O a bond T3g OH
    2798 CMe NMe Q1j a bond H a bond NH O a bond T3h OH
    2799 CMe NMe Q1j a bond H a bond NH O a bond T3i OH
    2800 CMe NMe Q1j a bond H a bond NH O a bond T3j OH
    2801 CMe S Q1a a bond Me a bond NH S NH T3a OH
    2802 CMe S Q1a a bond Me a bond NH S NH T3b OH
    2803 CMe S Q1a a bond Me a bond NH S NH T3c OH
    2804 CMe S Q1a a bond Me a bond NH S NH T3d OH
    2805 CMe S Q1a a bond Me a bond NH S NH T3e OH
    2806 CMe S Q1a a bond Me a bond NH S NH T3f OH
    2807 CMe S Q1a a bond Me a bond NH S NH T3g OH
    2808 CMe S Q1a a bond Me a bond NH S NH T3h OH
    2809 CMe S Q1a a bond Me a bond NH S NH T3i OH
    2810 CMe S Q1a a bond Me a bond NH S NH T3j OH
    2811 CMe S Q1a a bond Me a bond NH S a bond T3a OH
    2812 CMe S Q1a a bond Me a bond NH S a bond T3b OH
    2813 CMe S Q1a a bond Me a bond NH S a bond T3c OH
    2814 CMe S Q1a a bond Me a bond NH S a bond T3d OH
    2815 CMe S Q1a a bond Me a bond NH S a bond T3e OH
    2816 CMe S Q1a a bond Me a bond NH S a bond T3f OH
    2817 CMe S Q1a a bond Me a bond NH S a bond T3g OH
    2818 CMe S Q1a a bond Me a bond NH S a bond T3h OH
    2819 CMe S Q1a a bond Me a bond NH S a bond T3i OH
    2820 CMe S Q1a a bond Me a bond NH S a bond T3j OH
    2821 CMe S Q1a a bond Me a bond NH O NH T3a OH
    2822 CMe S Q1a a bond Me a bond NH O NH T3b OH
    2823 CMe S Q1a a bond Me a bond NH O NH T3c OH
    2824 CMe S Q1a a bond Me a bond NH O NH T3d OH
    2825 CMe S Q1a a bond Me a bond NH O NH T3e OH
    2826 CMe S Q1a a bond Me a bond NH O NH T3f OH
    2827 CMe S Q1a a bond Me a bond NH O NH T3g OH
    2828 CMe S Q1a a bond Me a bond NH O NH T3h OH
    2829 CMe S Q1a a bond Me a bond NH O NH T3i OH
    2830 CMe S Q1a a bond Me a bond NH O NH T3j OH
    2831 CMe S Q1a a bond Me a bond NH O a bond T3a OH
    2832 CMe S Q1a a bond Me a bond NH O a bond T3b OH
    2833 CMe S Q1a a bond Me a bond NH O a bond T3c OH
    2834 CMe S Q1a a bond Me a bond NH O a bond T3d OH
    2835 CMe S Q1a a bond Me a bond NH O a bond T3e OH
    2836 CMe S Q1a a bond Me a bond NH O a bond T3f OH
    2837 CMe S Q1a a bond Me a bond NH O a bond T3g OH
    2838 CMe S Q1a a bond Me a bond NH O a bond T3h OH
    2839 CMe S Q1a a bond Me a bond NH O a bond T3i OH
    2840 CMe S Q1a a bond Me a bond NH O a bond T3j OH
    2841 CMe S Q1a a bond H a bond NH S NH T3a OH
    2842 CMe S Q1a a bond H a bond NH S NH T3b OH
    2843 CMe S Q1a a bond H a bond NH S NH T3c OH
    2844 CMe S Q1a a bond H a bond NH S NH T3d OH
    2845 CMe S Q1a a bond H a bond NH S NH T3e OH
    2846 CMe S Q1a a bond H a bond NH S NH T3f OH
    2847 CMe S Q1a a bond H a bond NH S NH T3g OH
    2848 CMe S Q1a a bond H a bond NH S NH T3h OH
    2849 CMe S Q1a a bond H a bond NH S NH T3i OH
    2850 CMe S Q1a a bond H a bond NH S NH T3j OH
    2851 CMe S Q1a a bond H a bond NH S a bond T3a OH
    2852 CMe S Q1a a bond H a bond NH S a bond T3b OH
    2853 CMe S Q1a a bond H a bond NH S a bond T3c OH
    2854 CMe S Q1a a bond H a bond NH S a bond T3d OH
    2855 CMe S Q1a a bond H a bond NH S a bond T3e OH
    2856 CMe S Q1a a bond H a bond NH S a bond T3f OH
    2857 CMe S Q1a a bond H a bond NH S a bond T3g OH
    2858 CMe S Q1a a bond H a bond NH S a bond T3h OH
    2859 CMe S Q1a a bond H a bond NH S a bond T3i OH
    2860 CMe S Q1a a bond H a bond NH S a bond T3j OH
    2861 CMe S Q1a a bond H a bond NH O NH T3a OH
    2862 CMe S Q1a a bond H a bond NH O NH T3b OH
    2863 CMe S Q1a a bond H a bond NH O NH T3c OH
    2864 CMe S Q1a a bond H a bond NH O NH T3d OH
    2865 CMe S Q1a a bond H a bond NH O NH T3e OH
    2866 CMe S Q1a a bond H a bond NH O NH T3f OH
    2867 CMe S Q1a a bond H a bond NH O NH T3g OH
    2868 CMe S Q1a a bond H a bond NH O NH T3h OH
    2869 CMe S Q1a a bond H a bond NH O NH T3i OH
    2870 CMe S Q1a a bond H a bond NH O NH T3j OH
    2871 CMe S Q1a a bond H a bond NH O a bond T3a OH
    2872 CMe S Q1a a bond H a bond NH O a bond T3b OH
    2873 CMe S Q1a a bond H a bond NH O a bond T3c OH
    2874 CMe S Q1a a bond H a bond NH O a bond T3d OH
    2875 CMe S Q1a a bond H a bond NH O a bond T3e OH
    2876 CMe S Q1a a bond H a bond NH O a bond T3f OH
    2877 CMe S Q1a a bond H a bond NH O a bond T3g OH
    2878 CMe S Q1a a bond H a bond NH O a bond T3h OH
    2879 CMe S Q1a a bond H a bond NH O a bond T3i OH
    2880 CMe S Q1a a bond H a bond NH O a bond T3j OH
    2881 CMe S Q1b a bond Me a bond NH S NH T3a OH
    2882 CMe S Q1b a bond Me a bond NH S NH T3b OH
    2883 CMe S Q1b a bond Me a bond NH S NH T3c OH
    2884 CMe S Q1b a bond Me a bond NH S NH T3d OH
    2885 CMe S Q1b a bond Me a bond NH S NH T3e OH
    2886 CMe S Q1b a bond Me a bond NH S NH T3f OH
    2887 CMe S Q1b a bond Me a bond NH S NH T3g OH
    2888 CMe S Q1b a bond Me a bond NH S NH T3h OH
    2889 CMe S Q1b a bond Me a bond NH S NH T3i OH
    2890 CMe S Q1b a bond Me a bond NH S NH T3j OH
    2891 CMe S Q1b a bond Me a bond NH S a bond T3a OH
    2892 CMe S Q1b a bond Me a bond NH S a bond T3b OH
    2893 CMe S Q1b a bond Me a bond NH S a bond T3c OH
    2894 CMe S Q1b a bond Me a bond NH S a bond T3d OH
    2895 CMe S Q1b a bond Me a bond NH S a bond T3e OH
    2896 CMe S Q1b a bond Me a bond NH S a bond T3f OH
    2897 CMe S Q1b a bond Me a bond NH S a bond T3g OH
    2898 CMe S Q1b a bond Me a bond NH S a bond T3h OH
    2899 CMe S Q1b a bond Me a bond NH S a bond T3i OH
    2900 CMe S Q1b a bond Me a bond NH S a bond T3j OH
    2901 CMe S Q1b a bond Me a bond NH O NH T3a OH
    2902 CMe S Q1b a bond Me a bond NH O NH T3b OH
    2903 CMe S Q1b a bond Me a bond NH O NH T3c OH
    2904 CMe S Q1b a bond Me a bond NH O NH T3d OH
    2905 CMe S Q1b a bond Me a bond NH O NH T3e OH
    2906 CMe S Q1b a bond Me a bond NH O NH T3f OH
    2907 CMe S Q1b a bond Me a bond NH O NH T3g OH
    2908 CMe S Q1b a bond Me a bond NH O NH T3h OH
    2909 CMe S Q1b a bond Me a bond NH O NH T3i OH
    2910 CMe S Q1b a bond Me a bond NH O NH T3j OH
    2911 CMe S Q1b a bond Me a bond NH O a bond T3a OH
    2912 CMe S Q1b a bond Me a bond NH O a bond T3b OH
    2913 CMe S Q1b a bond Me a bond NH O a bond T3c OH
    2914 CMe S Q1b a bond Me a bond NH O a bond T3d OH
    2915 CMe S Q1b a bond Me a bond NH O a bond T3e OH
    2916 CMe S Q1b a bond Me a bond NH O a bond T3f OH
    2917 CMe S Q1b a bond Me a bond NH O a bond T3g OH
    2918 CMe S Q1b a bond Me a bond NH O a bond T3h OH
    2919 CMe S Q1b a bond Me a bond NH O a bond T3i OH
    2920 CMe S Q1b a bond Me a bond NH O a bond T3j OH
    2921 CMe S Q1b a bond H a bond NH S NH T3a OH
    2922 CMe S Q1b a bond H a bond NH S NH T3b OH
    2923 CMe S Q1b a bond H a bond NH S NH T3c OH
    2924 CMe S Q1b a bond H a bond NH S NH T3d OH
    2925 CMe S Q1b a bond H a bond NH S NH T3e OH
    2926 CMe S Q1b a bond H a bond NH S NH T3f OH
    2927 CMe S Q1b a bond H a bond NH S NH T3g OH
    2928 CMe S Q1b a bond H a bond NH S NH T3h OH
    2929 CMe S Q1b a bond H a bond NH S NH T3i OH
    2930 CMe S Q1b a bond H a bond NH S NH T3j OH
    2931 CMe S Q1b a bond H a bond NH S a bond T3a OH
    2932 CMe S Q1b a bond H a bond NH S a bond T3b OH
    2933 CMe S Q1b a bond H a bond NH S a bond T3c OH
    2934 CMe S Q1b a bond H a bond NH S a bond T3d OH
    2935 CMe S Q1b a bond H a bond NH S a bond T3e OH
    2936 CMe S Q1b a bond H a bond NH S a bond T3f OH
    2937 CMe S Q1b a bond H a bond NH S a bond T3g OH
    2938 CMe S Q1b a bond H a bond NH S a bond T3h OH
    2939 CMe S Q1b a bond H a bond NH S a bond T3i OH
    2940 CMe S Q1b a bond H a bond NH S a bond T3j OH
    2941 CMe S Q1b a bond H a bond NH O NH T3a OH
    2942 CMe S Q1b a bond H a bond NH O NH T3b OH
    2943 CMe S Q1b a bond H a bond NH O NH T3c OH
    2944 CMe S Q1b a bond H a bond NH O NH T3d OH
    2945 CMe S Q1b a bond H a bond NH O NH T3e OH
    2946 CMe S Q1b a bond H a bond NH O NH T3f OH
    2947 CMe S Q1b a bond H a bond NH O NH T3g OH
    2948 CMe S Q1b a bond H a bond NH O NH T3h OH
    2949 CMe S Q1b a bond H a bond NH O NH T3i OH
    2950 CMe S Q1b a bond H a bond NH O NH T3j OH
    2951 CMe S Q1b a bond H a bond NH O a bond T3a OH
    2952 CMe S Q1b a bond H a bond NH O a bond T3b OH
    2953 CMe S Q1b a bond H a bond NH O a bond T3c OH
    2954 CMe S Q1b a bond H a bond NH O a bond T3d OH
    2955 CMe S Q1b a bond H a bond NH O a bond T3e OH
    2956 CMe S Q1b a bond H a bond NH O a bond T3f OH
    2957 CMe S Q1b a bond H a bond NH O a bond T3g OH
    2958 CMe S Q1b a bond H a bond NH O a bond T3h OH
    2959 CMe S Q1b a bond H a bond NH O a bond T3i OH
    2960 CMe S Q1b a bond H a bond NH O a bond T3j OH
    2961 CMe S Q1c a bond Me a bond NH S NH T3a OH
    2962 CMe S Q1c a bond Me a bond NH S NH T3b OH
    2963 CMe S Q1c a bond Me a bond NH S NH T3c OH
    2964 CMe S Q1c a bond Me a bond NH S NH T3d OH
    2965 CMe S Q1c a bond Me a bond NH S NH T3e OH
    2966 CMe S Q1c a bond Me a bond NH S NH T3f OH
    2967 CMe S Q1c a bond Me a bond NH S NH T3g OH
    2968 CMe S Q1c a bond Me a bond NH S NH T3h OH
    2969 CMe S Q1c a bond Me a bond NH S NH T3i OH
    2970 CMe S Q1c a bond Me a bond NH S NH T3j OH
    2971 CMe S Q1c a bond Me a bond NH S a bond T3a OH
    2972 CMe S Q1c a bond Me a bond NH S a bond T3b OH
    2973 CMe S Q1c a bond Me a bond NH S a bond T3c OH
    2974 CMe S Q1c a bond Me a bond NH S a bond T3d OH
    2975 CMe S Q1c a bond Me a bond NH S a bond T3e OH
    2976 CMe S Q1c a bond Me a bond NH S a bond T3f OH
    2977 CMe S Q1c a bond Me a bond NH S a bond T3g OH
    2978 CMe S Q1c a bond Me a bond NH S a bond T3h OH
    2979 CMe S Q1c a bond Me a bond NH S a bond T3i OH
    2980 CMe S Q1c a bond Me a bond NH S a bond T3j OH
    2981 CMe S Q1c a bond Me a bond NH O NH T3a OH
    2982 CMe S Q1c a bond Me a bond NH O NH T3b OH
    2983 CMe S Q1c a bond Me a bond NH O NH T3c OH
    2984 CMe S Q1c a bond Me a bond NH O NH T3d OH
    2985 CMe S Q1c a bond Me a bond NH O NH T3e OH
    2986 CMe S Q1c a bond Me a bond NH O NH T3f OH
    2987 CMe S Q1c a bond Me a bond NH O NH T3g OH
    2988 CMe S Q1c a bond Me a bond NH O NH T3h OH
    2989 CMe S Q1c a bond Me a bond NH O NH T3i OH
    2990 CMe S Q1c a bond Me a bond NH O NH T3j OH
    2991 CMe S Q1c a bond Me a bond NH O a bond T3a OH
    2992 CMe S Q1c a bond Me a bond NH O a bond T3b OH
    2993 CMe S Q1c a bond Me a bond NH O a bond T3c OH
    2994 CMe S Q1c a bond Me a bond NH O a bond T3d OH
    2995 CMe S Q1c a bond Me a bond NH O a bond T3e OH
    2996 CMe S Q1c a bond Me a bond NH O a bond T3f OH
    2997 CMe S Q1c a bond Me a bond NH O a bond T3g OH
    2998 CMe S Q1c a bond Me a bond NH O a bond T3h OH
    2999 CMe S Q1c a bond Me a bond NH O a bond T3i OH
    3000 CMe S Q1c a bond Me a bond NH O a bond T3j OH
    3001 CMe S Q1c a bond H a bond NH S NH T3a OH
    3002 CMe S Q1c a bond H a bond NH S NH T3b OH
    3003 CMe S Q1c a bond H a bond NH S NH T3c OH
    3004 CMe S Q1c a bond H a bond NH S NH T3d OH
    3005 CMe S Q1c a bond H a bond NH S NH T3e OH
    3006 CMe S Q1c a bond H a bond NH S NH T3f OH
    3007 CMe S Q1c a bond H a bond NH S NH T3g OH
    3008 CMe S Q1c a bond H a bond NH S NH T3h OH
    3009 CMe S Q1c a bond H a bond NH S NH T3i OH
    3010 CMe S Q1c a bond H a bond NH S NH T3i OH
    3011 CMe S Q1c a bond H a bond NH S a bond T3a OH
    3012 CMe S Q1c a bond H a bond NH S a bond T3b OH
    3013 CMe S Q1c a bond H a bond NH S a bond T3c OH
    3014 CMe S Q1c a bond H a bond NH S a bond T3d OH
    3015 CMe S Q1c a bond H a bond NH S a bond T3e OH
    3016 CMe S Q1c a bond H a bond NH S a bond T3f OH
    3017 CMe S Q1c a bond H a bond NH S a bond T3g OH
    3018 CMe S Q1c a bond H a bond NH S a bond T3h OH
    3019 CMe S Q1c a bond H a bond NH S a bond T3i OH
    3020 CMe S Q1c a bond H a bond NH S a bond T3j OH
    3021 CMe S Q1c a bond H a bond NH O NH T3a OH
    3022 CMe S Q1c a bond H a bond NH O NH T3b OH
    3023 CMe S Q1c a bond H a bond NH O NH T3c OH
    3024 CMe S Q1c a bond H a bond NH O NH T3d OH
    3025 CMe S Q1c a bond H a bond NH O NH T3e OH
    3026 CMe S Q1c a bond H a bond NH O NH T3f OH
    3027 CMe S Q1c a bond H a bond NH O NH T3g OH
    3028 CMe S Q1c a bond H a bond NH O NH T3h OH
    3029 CMe S Q1c a bond H a bond NH O NH T3i OH
    3030 CMe S Q1c a bond H a bond NH O NH T3j OH
    3031 CMe S Q1c a bond H a bond NH O a bond T3a OH
    3032 CMe S Q1c a bond H a bond NH O a bond T3b OH
    3033 CMe S Q1c a bond H a bond NH O a bond T3c OH
    3034 CMe S Q1c a bond H a bond NH O a bond T3d OH
    3035 CMe S Q1c a bond H a bond NH O a bond T3e OH
    3036 CMe S Q1c a bond H a bond NH O a bond T3f OH
    3037 CMe S Q1c a bond H a bond NH O a bond T3g OH
    3038 CMe S Q1c a bond H a bond NH O a bond T3h OH
    3039 CMe S Q1c a bond H a bond NH O a bond T3i OH
    3040 CMe S Q1c a bond H a bond NH O a bond T3j OH
    3041 CMe S Q1i a bond Me a bond NH S NH T3a OH
    3042 CMe S Q1i a bond Me a bond NH S NH T3b OH
    3043 CMe S Q1i a bond Me a bond NH S NH T3c OH
    3044 CMe S Q1i a bond Me a bond NH S NH T3d OH
    3045 CMe S Q1i a bond Me a bond NH S NH T3e OH
    3046 CMe S Q1i a bond Me a bond NH S NH T3f OH
    3047 CMe S Q1i a bond Me a bond NH S NH T3g OH
    3048 CMe S Q1i a bond Me a bond NH S NH T3h OH
    3049 CMe S Q1i a bond Me a bond NH S NH T3i OH
    3050 CMe S Q1i a bond Me a bond NH S NH T3j OH
    3051 CMe S Q1i a bond Me a bond NH S a bond T3a OH
    3052 CMe S Q1i a bond Me a bond NH S a bond T3b OH
    3053 CMe S Q1i a bond Me a bond NH S a bond T3c OH
    3054 CMe S Q1i a bond Me a bond NH S a bond T3d OH
    3055 CMe S Q1i a bond Me a bond NH S a bond T3e OH
    3056 CMe S Q1i a bond Me a bond NH S a bond T3f OH
    3057 CMe S Q1i a bond Me a bond NH S a bond T3g OH
    3058 CMe S Q1i a bond Me a bond NH S a bond T3h OH
    3059 CMe S Q1i a bond Me a bond NH S a bond T3i OH
    3060 CMe S Q1i a bond Me a bond NH S a bond T3j OH
    3061 CMe S Q1i a bond Me a bond NH O NH T3a OH
    3062 CMe S Q1i a bond Me a bond NH O NH T3b OH
    3063 CMe S Q1i a bond Me a bond NH O NH T3c OH
    3064 CMe S Q1i a bond Me a bond NH O NH T3d OH
    3065 CMe S Q1i a bond Me a bond NH O NH T3e OH
    3066 CMe S Q1i a bond Me a bond NH O NH T3f OH
    3067 CMe S Q1i a bond Me a bond NH O NH T3g OH
    3068 CMe S Q1i a bond Me a bond NH O NH T3h OH
    3069 CMe S Q1i a bond Me a bond NH O NH T3i OH
    3070 CMe S Q1i a bond Me a bond NH O NH T3j OH
    3071 CMe S Q1i a bond Me a bond NH O a bond T3a OH
    3072 CMe S Q1i a bond Me a bond NH O a bond T3b OH
    3073 CMe S Q1i a bond Me a bond NH O a bond T3c OH
    3074 CMe S Q1i a bond Me a bond NH O a bond T3d OH
    3075 CMe S Q1i a bond Me a bond NH O a bond T3e OH
    3076 CMe S Q1i a bond Me a bond NH O a bond T3f OH
    3077 CMe S Q1i a bond Me a bond NH O a bond T3g OH
    3078 CMe S Q1i a bond Me a bond NH O a bond T3h OH
    3079 CMe S Q1i a bond Me a bond NH O a bond T3i OH
    3080 CMe S Q1i a bond Me a bond NH O a bond T3j OH
    3081 CMe S Q1i a bond H a bond NH S NH T3a OH
    3082 CMe S Q1i a bond H a bond NH S NH T3b OH
    3083 CMe S Q1i a bond H a bond NH S NH T3c OH
    3084 CMe S Q1i a bond H a bond NH S NH T3d OH
    3085 CMe S Q1i a bond H a bond NH S NH T3e OH
    3086 CMe S Q1i a bond H a bond NH S NH T3f OH
    3087 CMe S Q1i a bond H a bond NH S NH T3g OH
    3088 CMe S Q1i a bond H a bond NH S NH T3h OH
    3089 CMe S Q1i a bond H a bond NH S NH T3i OH
    3090 CMe S Q1i a bond H a bond NH S NH T3j OH
    3091 CMe S Q1i a bond H a bond NH S a bond T3a OH
    3092 CMe S Q1i a bond H a bond NH S a bond T3b OH
    3093 CMe S Q1i a bond H a bond NH S a bond T3c OH
    3094 CMe S Q1i a bond H a bond NH S a bond T3d OH
    3095 CMe S Q1i a bond H a bond NH S a bond T3e OH
    3096 CMe S Q1i a bond H a bond NH S a bond T3f OH
    3097 CMe S Q1i a bond H a bond NH S a bond T3g OH
    3098 CMe S Q1i a bond H a bond NH S a bond T3h OH
    3099 CMe S Q1i a bond H a bond NH S a bond T3i OH
    3100 CMe S Q1i a bond H a bond NH S a bond T3j OH
    3101 CMe S Q1i a bond H a bond NH O NH T3a OH
    3102 CMe S Q1i a bond H a bond NH O NH T3b OH
    3103 CMe S Q1i a bond H a bond NH O NH T3c OH
    3104 CMe S Q1i a bond H a bond NH O NH T3d OH
    3105 CMe S Q1i a bond H a bond NH O NH T3e OH
    3106 CMe S Q1i a bond H a bond NH O NH T3f OH
    3107 CMe S Q1i a bond H a bond NH O NH T3g OH
    3108 CMe S Q1i a bond H a bond NH O NH T3h OH
    3109 CMe S Q1i a bond H a bond NH O NH T3i OH
    3110 CMe S Q1i a bond H a bond NH O NH T3j OH
    3111 CMe S Q1i a bond H a bond NH O a bond T3a OH
    3112 CMe S Q1i a bond H a bond NH O a bond T3b OH
    3113 CMe S Q1i a bond H a bond NH O a bond T3c OH
    3114 CMe S Q1i a bond H a bond NH O a bond T3d OH
    3115 CMe S Q1i a bond H a bond NH O a bond T3e OH
    3116 CMe S Q1i a bond H a bond NH O a bond T3f OH
    3117 CMe S Q1i a bond H a bond NH O a bond T3g OH
    3118 CMe S Q1i a bond H a bond NH O a bond T3h OH
    3119 CMe S Q1i a bond H a bond NH O a bond T3i OH
    3120 CMe S Q1i a bond H a bond NH O a bond T3j OH
    3121 CMe S Q1j a bond Me a bond NH S NH T3a OH
    3122 CMe S Q1j a bond Me a bond NH S NH T3b OH
    3123 CMe S Q1j a bond Me a bond NH S NH T3c OH
    3124 CMe S Q1j a bond Me a bond NH S NH T3d OH
    3125 CMe S Q1j a bond Me a bond NH S NH T3e OH
    3126 CMe S Q1j a bond Me a bond NH S NH T3f OH
    3127 CMe S Q1j a bond Me a bond NH S NH T3g OH
    3128 CMe S Q1j a bond Me a bond NH S NH T3h OH
    3129 CMe S Q1j a bond Me a bond NH S NH T3i OH
    3130 CMe S Q1j a bond Me a bond NH S NH T3j OH
    3131 CMe S Q1j a bond Me a bond NH S a bond T3a OH
    3132 CMe S Q1j a bond Me a bond NH S a bond T3b OH
    3133 CMe S Q1j a bond Me a bond NH S a bond T3c OH
    3134 CMe S Q1j a bond Me a bond NH S a bond T3d OH
    3135 CMe S Q1j a bond Me a bond NH S a bond T3e OH
    3136 CMe S Q1j a bond Me a bond NH S a bond T3f OH
    3137 CMe S Q1j a bond Me a bond NH S a bond T3g OH
    3138 CMe S Q1j a bond Me a bond NH S a bond T3h OH
    3139 CMe S Q1j a bond Me a bond NH S a bond T3i OH
    3140 CMe S Q1j a bond Me a bond NH S a bond T3j OH
    3141 CMe S Q1j a bond Me a bond NH O NH T3a OH
    3142 CMe S Q1j a bond Me a bond NH O NH T3b OH
    3143 CMe S Q1j a bond Me a bond NH O NH T3c OH
    3144 CMe S Q1j a bond Me a bond NH O NH T3d OH
    3145 CMe S Q1j a bond Me a bond NH O NH T3e OH
    3146 CMe S Q1j a bond Me a bond NH O NH T3f OH
    3147 CMe S Q1j a bond Me a bond NH O NH T3g OH
    3148 CMe S Q1j a bond Me a bond NH O NH T3h OH
    3149 CMe S Q1j a bond Me a bond NH O NH T3i OH
    3150 CMe S Q1j a bond Me a bond NH O NH T3j OH
    3151 CMe S Q1j a bond Me a bond NH O a bond T3a OH
    3152 CMe S Q1j a bond Me a bond NH O a bond T3b OH
    3153 CMe S Q1j a bond Me a bond NH O a bond T3c OH
    3154 CMe S Q1j a bond Me a bond NH O a bond T3d OH
    3155 CMe S Q1j a bond Me a bond NH O a bond T3e OH
    3156 CMe S Q1j a bond Me a bond NH O a bond T3f OH
    3157 CMe S Q1j a bond Me a bond NH O a bond T3g OH
    3158 CMe S Q1j a bond Me a bond NH O a bond T3h OH
    3159 CMe S Q1j a bond Me a bond NH O a bond T3i OH
    3160 CMe S Q1j a bond Me a bond NH O a bond T3j OH
    3161 CMe S Q1j a bond H a bond NH S NH T3a OH
    3162 CMe S Q1j a bond H a bond NH S NH T3b OH
    3163 CMe S Q1j a bond H a bond NH S NH T3c OH
    3164 CMe S Q1j a bond H a bond NH S NH T3d OH
    3165 CMe S Q1j a bond H a bond NH S NH T3e OH
    3166 CMe S Q1j a bond H a bond NH S NH T3f OH
    3167 CMe S Q1j a bond H a bond NH S NH T3g OH
    3168 CMe S Q1j a bond H a bond NH S NH T3h OH
    3169 CMe S Q1j a bond H a bond NH S NH T3i OH
    3170 CMe S Q1j a bond H a bond NH S NH T3j OH
    3171 CMe S Q1j a bond H a bond NH S a bond T3a OH
    3172 CMe S Q1j a bond H a bond NH S a bond T3b OH
    3173 CMe S Q1j a bond H a bond NH S a bond T3c OH
    3174 CMe S Q1j a bond H a bond NH S a bond T3d OH
    3175 CMe S Q1j a bond H a bond NH S a bond T3e OH
    3176 CMe S Q1j a bond H a bond NH S a bond T3f OH
    3177 CMe S Q1j a bond H a bond NH S a bond T3g OH
    3178 CMe S Q1j a bond H a bond NH S a bond T3h OH
    3179 CMe S Q1j a bond H a bond NH S a bond T3i OH
    3180 CMe S Q1j a bond H a bond NH S a bond T3j OH
    3181 CMe S Q1j a bond H a bond NH O NH T3a OH
    3182 CMe S Q1j a bond H a bond NH O NH T3b OH
    3183 CMe S Q1j a bond H a bond NH O NH T3c OH
    3184 CMe S Q1j a bond H a bond NH O NH T3d OH
    3185 CMe S Q1j a bond H a bond NH O NH T3e OH
    3186 CMe S Q1j a bond H a bond NH O NH T3f OH
    3187 CMe S Q1j a bond H a bond NH O NH T3g OH
    3188 CMe S Q1j a bond H a bond NH O NH T3h OH
    3189 CMe S Q1j a bond H a bond NH O NH T3i OH
    3190 CMe S Q1j a bond H a bond NH O NH T3j OH
    3191 CMe S Q1j a bond H a bond NH O a bond T3a OH
    3192 CMe S Q1j a bond H a bond NH O a bond T3b OH
    3193 CMe S Q1j a bond H a bond NH O a bond T3c OH
    3194 CMe S Q1j a bond H a bond NH O a bond T3d OH
    3195 CMe S Q1j a bond H a bond NH O a bond T3e OH
    3196 CMe S Q1j a bond H a bond NH O a bond T3f OH
    3197 CMe S Q1j a bond H a bond NH O a bond T3g OH
    3198 CMe S Q1j a bond H a bond NH O a bond T3h OH
    3199 CMe S Q1j a bond H a bond NH O a bond T3i OH
    3200 CMe S Q1j a bond H a bond NH O a bond T3j OH
    3201 CMe O Q1a a bond Me a bond NH S NH T3a OH
    3202 CMe O Q1a a bond Me a bond NH S NH T3b OH
    3203 CMe O Q1a a bond Me a bond NH S NH T3c OH
    3204 CMe O Q1a a bond Me a bond NH S NH T3d OH
    3205 CMe O Q1a a bond Me a bond NH S NH T3e OH
    3206 CMe O Q1a a bond Me a bond NH S NH T3f OH
    3207 CMe O Q1a a bond Me a bond NH S NH T3g OH
    3208 CMe O Q1a a bond Me a bond NH S NH T3h OH
    3209 CMe O Q1a a bond Me a bond NH S NH T3i OH
    3210 CMe O Q1a a bond Me a bond NH S NH T3j OH
    3211 CMe O Q1a a bond Me a bond NH S a bond T3a OH
    3212 CMe O Q1a a bond Me a bond NH S a bond T3b OH
    3213 CMe O Q1a a bond Me a bond NH S a bond T3c OH
    3214 CMe O Q1a a bond Me a bond NH S a bond T3d OH
    3215 CMe O Q1a a bond Me a bond NH S a bond T3e OH
    3216 CMe O Q1a a bond Me a bond NH S a bond T3f OH
    3217 CMe O Q1a a bond Me a bond NH S a bond T3g OH
    3218 CMe O Q1a a bond Me a bond NH S a bond T3h OH
    3219 CMe O Q1a a bond Me a bond NH S a bond T3i OH
    3220 CMe O Q1a a bond Me a bond NH S a bond T3j OH
    3221 CMe O Q1a a bond Me a bond NH O NH T3a OH
    3222 CMe O Q1a a bond Me a bond NH O NH T3b OH
    3223 CMe O Q1a a bond Me a bond NH O NH T3c OH
    3224 CMe O Q1a a bond Me a bond NH O NH T3d OH
    3225 CMe O Q1a a bond Me a bond NH O NH T3e OH
    3226 CMe O Q1a a bond Me a bond NH O NH T3f OH
    3227 CMe O Q1a a bond Me a bond NH O NH T3g OH
    3228 CMe O Q1a a bond Me a bond NH O NH T3h OH
    3229 CMe O Q1a a bond Me a bond NH O NH T3i OH
    3230 CMe O Q1a a bond Me a bond NH O NH T3j OH
    3231 CMe O Q1a a bond Me a bond NH O a bond T3a OH
    3232 CMe O Q1a a bond Me a bond NH O a bond T3b OH
    3233 CMe O Q1a a bond Me a bond NH O a bond T3c OH
    3234 CMe O Q1a a bond Me a bond NH O a bond T3d OH
    3235 CMe O Q1a a bond Me a bond NH O a bond T3e OH
    3236 CMe O Q1a a bond Me a bond NH O a bond T3f OH
    3237 CMe O Q1a a bond Me a bond NH O a bond T3g OH
    3238 CMe O Q1a a bond Me a bond NH O a bond T3h OH
    3239 CMe O Q1a a bond Me a bond NH O a bond T3i OH
    3240 CMe O Q1a a bond Me a bond NH O a bond T3j OH
    3241 CMe O Q1a a bond H a bond NH S NH T3a OH
    3242 CMe O Q1a a bond H a bond NH S NH T3b OH
    3243 CMe O Q1a a bond H a bond NH S NH T3c OH
    3244 CMe O Q1a a bond H a bond NH S NH T3d OH
    3245 CMe O Q1a a bond H a bond NH S NH T3e OH
    3246 CMe O Q1a a bond H a bond NH S NH T3f OH
    3247 CMe O Q1a a bond H a bond NH S NH T3g OH
    3248 CMe O Q1a a bond H a bond NH S NH T3h OH
    3249 CMe O Q1a a bond H a bond NH S NH T3i OH
    3250 CMe O Q1a a bond H a bond NH S NH T3j OH
    3251 CMe O Q1a a bond H a bond NH S a bond T3a OH
    3252 CMe O Q1a a bond H a bond NH S a bond T3b OH
    3253 CMe O Q1a a bond H a bond NH S a bond T3c OH
    3254 CMe O Q1a a bond H a bond NH S a bond T3d OH
    3255 CMe O Q1a a bond H a bond NH S a bond T3e OH
    3256 CMe O Q1a a bond H a bond NH S a bond T3f OH
    3257 CMe O Q1a a bond H a bond NH S a bond T3g OH
    3258 CMe O Q1a a bond H a bond NH S a bond T3h OH
    3259 CMe O Q1a a bond H a bond NH S a bond T3i OH
    3260 CMe O Q1a a bond H a bond NH S a bond T3j OH
    3261 CMe O Q1a a bond H a bond NH O NH T3a OH
    3262 CMe O Q1a a bond H a bond NH O NH T3b OH
    3263 CMe O Q1a a bond H a bond NH O NH T3c OH
    3264 CMe O Q1a a bond H a bond NH O NH T3d OH
    3265 CMe O Q1a a bond H a bond NH O NH T3e OH
    3266 CMe O Q1a a bond H a bond NH O NH T3f OH
    3267 CMe O Q1a a bond H a bond NH O NH T3g OH
    3268 CMe O Q1a a bond H a bond NH O NH T3h OH
    3269 CMe O Q1a a bond H a bond NH O NH T3i OH
    3270 CMe O Q1a a bond H a bond NH O NH T3j OH
    3271 CMe O Q1a a bond H a bond NH O a bond T3a OH
    3272 CMe O Q1a a bond H a bond NH O a bond T3b OH
    3273 CMe O Q1a a bond H a bond NH O a bond T3c OH
    3274 CMe O Q1a a bond H a bond NH O a bond T3d OH
    3275 CMe O Q1a a bond H a bond NH O a bond T3e OH
    3276 CMe O Q1a a bond H a bond NH O a bond T3f OH
    3277 CMe O Q1a a bond H a bond NH O a bond T3g OH
    3278 CMe O Q1a a bond H a bond NH O a bond T3h OH
    3279 CMe O Q1a a bond H a bond NH O a bond T3i OH
    3280 CMe O Q1a a bond H a bond NH O a bond T3j OH
    3281 CMe O Q1b a bond Me a bond NH S NH T3a OH
    3282 CMe O Q1b a bond Me a bond NH S NH T3b OH
    3283 CMe O Q1b a bond Me a bond NH S NH T3c OH
    3284 CMe O Q1b a bond Me a bond NH S NH T3d OH
    3285 CMe O Q1b a bond Me a bond NH S NH T3e OH
    3286 CMe O Q1b a bond Me a bond NH S NH T3f OH
    3287 CMe O Q1b a bond Me a bond NH S NH T3g OH
    3288 CMe O Q1b a bond Me a bond NH S NH T3h OH
    3289 CMe O Q1b a bond Me a bond NH S NH T3i OH
    3290 CMe O Q1b a bond Me a bond NH S NH T3j OH
    3291 CMe O Q1b a bond Me a bond NH S a bond T3a OH
    3292 CMe O Q1b a bond Me a bond NH S a bond T3b OH
    3293 CMe O Q1b a bond Me a bond NH S a bond T3c OH
    3294 CMe O Q1b a bond Me a bond NH S a bond T3d OH
    3295 CMe O Q1b a bond Me a bond NH S a bond T3e OH
    3296 CMe O Q1b a bond Me a bond NH S a bond T3f OH
    3297 CMe O Q1b a bond Me a bond NH S a bond T3g OH
    3298 CMe O Q1b a bond Me a bond NH S a bond T3h OH
    3299 CMe O Q1b a bond Me a bond NH S a bond T3i OH
    3300 CMe O Q1b a bond Me a bond NH S a bond T3j OH
    3301 CMe O Q1b a bond Me a bond NH O NH T3a OH
    3302 CMe O Q1b a bond Me a bond NH O NH T3b OH
    3303 CMe O Q1b a bond Me a bond NH O NH T3c OH
    3304 CMe O Q1b a bond Me a bond NH O NH T3d OH
    3305 CMe O Q1b a bond Me a bond NH O NH T3e OH
    3306 CMe O Q1b a bond Me a bond NH O NH T3f OH
    3307 CMe O Q1b a bond Me a bond NH O NH T3g OH
    3308 CMe O Q1b a bond Me a bond NH O NH T3h OH
    3309 CMe O Q1b a bond Me a bond NH O NH T3i OH
    3310 CMe O Q1b a bond Me a bond NH O NH T3j OH
    3311 CMe O Q1b a bond Me a bond NH O a bond T3a OH
    3312 CMe O Q1b a bond Me a bond NH O a bond T3b OH
    3313 CMe O Q1b a bond Me a bond NH O a bond T3c OH
    3314 CMe O Q1b a bond Me a bond NH O a bond T3d OH
    3315 CMe O Q1b a bond Me a bond NH O a bond T3e OH
    3316 CMe O Q1b a bond Me a bond NH O a bond T3f OH
    3317 CMe O Q1b a bond Me a bond NH O a bond T3g OH
    3318 CMe O Q1b a bond Me a bond NH O a bond T3h OH
    3319 CMe O Q1b a bond Me a bond NH O a bond T3i OH
    3320 CMe O Q1b a bond Me a bond NH O a bond T3j OH
    3321 CMe O Q1b a bond H a bond NH S NH T3a OH
    3322 CMe O Q1b a bond H a bond NH S NH T3b OH
    3323 CMe O Q1b a bond H a bond NH S NH T3c OH
    3324 CMe O Q1b a bond H a bond NH S NH T3d OH
    3325 CMe O Q1b a bond H a bond NH S NH T3e OH
    3326 CMe O Q1b a bond H a bond NH S NH T3f OH
    3327 CMe O Q1b a bond H a bond NH S NH T3g OH
    3328 CMe O Q1b a bond H a bond NH S NH T3h OH
    3329 CMe O Q1b a bond H a bond NH S NH T3i OH
    3330 CMe O Q1b a bond H a bond NH S NH T3j OH
    3331 CMe O Q1b a bond H a bond NH S a bond T3a OH
    3332 CMe O Q1b a bond H a bond NH S a bond T3b OH
    3333 CMe O Q1b a bond H a bond NH S a bond T3c OH
    3334 CMe O Q1b a bond H a bond NH S a bond T3d OH
    3335 CMe O Q1b a bond H a bond NH S a bond T3e OH
    3336 CMe O Q1b a bond H a bond NH S a bond T3f OH
    3337 CMe O Q1b a bond H a bond NH S a bond T3g OH
    3338 CMe O Q1b a bond H a bond NH S a bond T3h OH
    3339 CMe O Q1b a bond H a bond NH S a bond T3i OH
    3340 CMe O Q1b a bond H a bond NH S a bond T3j OH
    3341 CMe O Q1b a bond H a bond NH O NH T3a OH
    3342 CMe O Q1b a bond H a bond NH O NH T3b OH
    3343 CMe O Q1b a bond H a bond NH O NH T3c OH
    3344 CMe O Q1b a bond H a bond NH O NH T3d OH
    3345 CMe O Q1b a bond H a bond NH O NH T3e OH
    3346 CMe O Q1b a bond H a bond NH O NH T3f OH
    3347 CMe O Q1b a bond H a bond NH O NH T3g OH
    3348 CMe O Q1b a bond H a bond NH O NH T3h OH
    3349 CMe O Q1b a bond H a bond NH O NH T3i OH
    3350 CMe O Q1b a bond H a bond NH O NH T3j OH
    3351 CMe O Q1b a bond H a bond NH O a bond T3a OH
    3352 CMe O Q1b a bond H a bond NH O a bond T3b OH
    3353 CMe O Q1b a bond H a bond NH O a bond T3c OH
    3354 CMe O Q1b a bond H a bond NH O a bond T3d OH
    3355 CMe O Q1b a bond H a bond NH O a bond T3e OH
    3356 CMe O Q1b a bond H a bond NH O a bond T3f OH
    3357 CMe O Q1b a bond H a bond NH O a bond T3g OH
    3358 CMe O Q1b a bond H a bond NH O a bond T3h OH
    3359 CMe O Q1b a bond H a bond NH O a bond T3i OH
    3360 CMe O Q1b a bond H a bond NH O a bond T3j OH
    3361 CMe O Q1c a bond Me a bond NH S NH T3a OH
    3362 CMe O Q1c a bond Me a bond NH S NH T3b OH
    3363 CMe O Q1c a bond Me a bond NH S NH T3c OH
    3364 CMe O Q1c a bond Me a bond NH S NH T3d OH
    3365 CMe O Q1c a bond Me a bond NH S NH T3e OH
    3366 CMe O Q1c a bond Me a bond NH S NH T3f OH
    3367 CMe O Q1c a bond Me a bond NH S NH T3g OH
    3368 CMe O Q1c a bond Me a bond NH S NH T3h OH
    3369 CMe O Q1c a bond Me a bond NH S NH T3i OH
    3370 CMe O Q1c a bond Me a bond NH S NH T3j OH
    3371 CMe O Q1c a bond Me a bond NH S a bond T3a OH
    3372 CMe O Q1c a bond Me a bond NH S a bond T3b OH
    3373 CMe O Q1c a bond Me a bond NH S a bond T3c OH
    3374 CMe O Q1c a bond Me a bond NH S a bond T3d OH
    3375 CMe O Q1c a bond Me a bond NH S a bond T3e OH
    3376 CMe O Q1c a bond Me a bond NH S a bond T3f OH
    3377 CMe O Q1c a bond Me a bond NH S a bond T3g OH
    3378 CMe O Q1c a bond Me a bond NH S a bond T3h OH
    3379 CMe O Q1c a bond Me a bond NH S a bond T3i OH
    3380 CMe O Q1c a bond Me a bond NH S a bond T3j OH
    3381 CMe O Q1c a bond Me a bond NH O NH T3a OH
    3382 CMe O Q1c a bond Me a bond NH O NH T3b OH
    3383 CMe O Q1c a bond Me a bond NH O NH T3c OH
    3384 CMe O Q1c a bond Me a bond NH O NH T3d OH
    3385 CMe O Q1c a bond Me a bond NH O NH T3e OH
    3386 CMe O Q1c a bond Me a bond NH O NH T3f OH
    3387 CMe O Q1c a bond Me a bond NH O NH T3g OH
    3388 CMe O Q1c a bond Me a bond NH O NH T3h OH
    3389 CMe O Q1c a bond Me a bond NH O NH T3i OH
    3390 CMe O Q1c a bond Me a bond NH O NH T3j OH
    3391 CMe O Q1c a bond Me a bond NH O a bond T3a OH
    3392 CMe O Q1c a bond Me a bond NH O a bond T3b OH
    3393 CMe O Q1c a bond Me a bond NH O a bond T3c OH
    3394 CMe O Q1c a bond Me a bond NH O a bond T3d OH
    3395 CMe O Q1c a bond Me a bond NH O a bond T3e OH
    3396 CMe O Q1c a bond Me a bond NH O a bond T3f OH
    3397 CMe O Q1c a bond Me a bond NH O a bond T3g OH
    3398 CMe O Q1c a bond Me a bond NH O a bond T3h OH
    3399 CMe O Q1c a bond Me a bond NH O a bond T3i OH
    3400 CMe O Q1c a bond Me a bond NH O a bond T3j OH
    3401 CMe O Q1c a bond H a bond NH S NH T3a OH
    3402 CMe O Q1c a bond H a bond NH S NH T3b OH
    3403 CMe O Q1c a bond H a bond NH S NH T3c OH
    3404 CMe O Q1c a bond H a bond NH S NH T3d OH
    3405 CMe O Q1c a bond H a bond NH S NH T3e OH
    3406 CMe O Q1c a bond H a bond NH S NH T3f OH
    3407 CMe O Q1c a bond H a bond NH S NH T3g OH
    3408 CMe O Q1c a bond H a bond NH S NH T3h OH
    3409 CMe O Q1c a bond H a bond NH S NH T3i OH
    3410 CMe O Q1c a bond H a bond NH S NH T3j OH
    3411 CMe O Q1c a bond H a bond NH S a bond T3a OH
    3412 CMe O Q1c a bond H a bond NH S a bond T3b OH
    3413 CMe O Q1c a bond H a bond NH S a bond T3c OH
    3414 CMe O Q1c a bond H a bond NH S a bond T3d OH
    3415 CMe O Q1c a bond H a bond NH S a bond T3e OH
    3416 CMe O Q1c a bond H a bond NH S a bond T3f OH
    3417 CMe O Q1c a bond H a bond NH S a bond T3g OH
    3418 CMe O Q1c a bond H a bond NH S a bond T3h OH
    3419 CMe O Q1c a bond H a bond NH S a bond T3i OH
    3420 CMe O Q1c a bond H a bond NH S a bond T3j OH
    3421 CMe O Q1c a bond H a bond NH O NH T3a OH
    3422 CMe O Q1c a bond H a bond NH O NH T3b OH
    3423 CMe O Q1c a bond H a bond NH O NH T3c OH
    3424 CMe O Q1c a bond H a bond NH O NH T3d OH
    3425 CMe O Q1c a bond H a bond NH O NH T3e OH
    3426 CMe O Q1c a bond H a bond NH O NH T3f OH
    3427 CMe O Q1c a bond H a bond NH O NH T3g OH
    3428 CMe O Q1c a bond H a bond NH O NH T3h OH
    3429 CMe O Q1c a bond H a bond NH O NH T3i OH
    3430 CMe O Q1c a bond H a bond NH O NH T3j OH
    3431 CMe O Q1c a bond H a bond NH O a bond T3a OH
    3432 CMe O Q1c a bond H a bond NH O a bond T3b OH
    3433 CMe O Q1c a bond H a bond NH O a bond T3c OH
    3434 CMe O Q1c a bond H a bond NH O a bond T3d OH
    3435 CMe O Q1c a bond H a bond NH O a bond T3e OH
    3436 CMe O Q1c a bond H a bond NH O a bond T3f OH
    3437 CMe O Q1c a bond H a bond NH O a bond T3g OH
    3438 CMe O Q1c a bond H a bond NH O a bond T3h OH
    3439 CMe O Q1c a bond H a bond NH O a bond T3i OH
    3440 CMe O Q1c a bond H a bond NH O a bond T3j OH
    3441 CMe O Q1i a bond Me a bond NH S NH T3a OH
    3442 CMe O Q1i a bond Me a bond NH S NH T3b OH
    3443 CMe O Q1i a bond Me a bond NH S NH T3c OH
    3444 CMe O Q1i a bond Me a bond NH S NH T3d OH
    3445 CMe O Q1i a bond Me a bond NH S NH T3e OH
    3446 CMe O Q1i a bond Me a bond NH S NH T3f OH
    3447 CMe O Q1i a bond Me a bond NH S NH T3g OH
    3448 CMe O Q1i a bond Me a bond NH S NH T3h OH
    3449 CMe O Q1i a bond Me a bond NH S NH T3i OH
    3450 CMe O Q1i a bond Me a bond NH S NH T3j OH
    3451 CMe O Q1i a bond Me a bond NH S a bond T3a OH
    3452 CMe O Q1i a bond Me a bond NH S a bond T3b OH
    3453 CMe O Q1i a bond Me a bond NH S a bond T3c OH
    3454 CMe O Q1i a bond Me a bond NH S a bond T3d OH
    3455 CMe O Q1i a bond Me a bond NH S a bond T3e OH
    3456 CMe O Q1i a bond Me a bond NH S a bond T3f OH
    3457 CMe O Q1i a bond Me a bond NH S a bond T3g OH
    3458 CMe O Q1i a bond Me a bond NH S a bond T3h OH
    3459 CMe O Q1i a bond Me a bond NH S a bond T3i OH
    3460 CMe O Q1i a bond Me a bond NH S a bond T3j OH
    3461 CMe O Q1i a bond Me a bond NH O NH T3a OH
    3462 CMe O Q1i a bond Me a bond NH O NH T3b OH
    3463 CMe O Q1i a bond Me a bond NH O NH T3c OH
    3464 CMe O Q1i a bond Me a bond NH O NH T3d OH
    3465 CMe O Q1i a bond Me a bond NH O NH T3e OH
    3466 CMe O Q1i a bond Me a bond NH O NH T3f OH
    3467 CMe O Q1i a bond Me a bond NH O NH T3g OH
    3468 CMe O Q1i a bond Me a bond NH O NH T3h OH
    3469 CMe O Q1i a bond Me a bond NH O NH T3i OH
    3470 CMe O Q1i a bond Me a bond NH O NH T3j OH
    3471 CMe O Q1i a bond Me a bond NH O a bond T3a OH
    3472 CMe O Q1i a bond Me a bond NH O a bond T3b OH
    3473 CMe O Q1i a bond Me a bond NH O a bond T3c OH
    3474 CMe O Q1i a bond Me a bond NH O a bond T3d OH
    3475 CMe O Q1i a bond Me a bond NH O a bond T3e OH
    3476 CMe O Q1i a bond Me a bond NH O a bond T3f OH
    3477 CMe O Q1i a bond Me a bond NH O a bond T3g OH
    3478 CMe O Q1i a bond Me a bond NH O a bond T3h OH
    3479 CMe O Q1i a bond Me a bond NH O a bond T3i OH
    3480 CMe O Q1i a bond Me a bond NH O a bond T3j OH
    3481 CMe O Q1i a bond H a bond NH S NH T3a OH
    3482 CMe O Q1i a bond H a bond NH S NH T3b OH
    3483 CMe O Q1i a bond H a bond NH S NH T3c OH
    3484 CMe O Q1i a bond H a bond NH S NH T3d OH
    3485 CMe O Q1i a bond H a bond NH S NH T3e OH
    3486 CMe O Q1i a bond H a bond NH S NH T3f OH
    3487 CMe O Q1i a bond H a bond NH S NH T3g OH
    3488 CMe O Q1i a bond H a bond NH S NH T3h OH
    3489 CMe O Q1i a bond H a bond NH S NH T3i OH
    3490 CMe O Q1i a bond H a bond NH S NH T3j OH
    3491 CMe O Q1i a bond H a bond NH S a bond T3a OH
    3492 CMe O Q1i a bond H a bond NH S a bond T3b OH
    3493 CMe O Q1i a bond H a bond NH S a bond T3c OH
    3494 CMe O Q1i a bond H a bond NH S a bond T3d OH
    3495 CMe O Q1i a bond H a bond NH S a bond T3e OH
    3496 CMe O Q1i a bond H a bond NH S a bond T3f OH
    3497 CMe O Q1i a bond H a bond NH S a bond T3g OH
    3498 CMe O Q1i a bond H a bond NH S a bond T3h OH
    3499 CMe O Q1i a bond H a bond NH S a bond T3i OH
    3500 CMe O Q1i a bond H a bond NH S a bond T3j OH
    3501 CMe O Q1i a bond H a bond NH O NH T3a OH
    3502 CMe O Q1i a bond H a bond NH O NH T3b OH
    3503 CMe O Q1i a bond H a bond NH O NH T3c OH
    3504 CMe O Q1i a bond H a bond NH O NH T3d OH
    3505 CMe O Q1i a bond H a bond NH O NH T3e OH
    3506 CMe O Q1i a bond H a bond NH O NH T3f OH
    3507 CMe O Q1i a bond H a bond NH O NH T3g OH
    3508 CMe O Q1i a bond H a bond NH O NH T3h OH
    3509 CMe O Q1i a bond H a bond NH O NH T3i OH
    3510 CMe O Q1i a bond H a bond NH O NH T3j OH
    3511 CMe O Q1i a bond H a bond NH O a bond T3a OH
    3512 CMe O Q1i a bond H a bond NH O a bond T3b OH
    3513 CMe O Q1i a bond H a bond NH O a bond T3c OH
    3514 CMe O Q1i a bond H a bond NH O a bond T3d OH
    3515 CMe O Q1i a bond H a bond NH O a bond T3e OH
    3516 CMe O Q1i a bond H a bond NH O a bond T3f OH
    3517 CMe O Q1i a bond H a bond NH O a bond T3g OH
    3518 CMe O Q1i a bond H a bond NH O a bond T3h OH
    3519 CMe O Q1i a bond H a bond NH O a bond T3i OH
    3520 CMe O Q1i a bond H a bond NH O a bond T3j OH
    3521 CMe O Q1j a bond Me a bond NH S NH T3a OH
    3522 CMe O Q1j a bond Me a bond NH S NH T3b OH
    3523 CMe O Q1j a bond Me a bond NH S NH T3c OH
    3524 CMe O Q1j a bond Me a bond NH S NH T3d OH
    3525 CMe O Q1j a bond Me a bond NH S NH T3e OH
    3526 CMe O Q1j a bond Me a bond NH S NH T3f OH
    3527 CMe O Q1j a bond Me a bond NH S NH T3g OH
    3528 CMe O Q1j a bond Me a bond NH S NH T3h OH
    3529 CMe O Q1j a bond Me a bond NH S NH T3i OH
    3530 CMe O Q1j a bond Me a bond NH S NH T3j OH
    3531 CMe O Q1j a bond Me a bond NH S a bond T3a OH
    3532 CMe O Q1j a bond Me a bond NH S a bond T3b OH
    3533 CMe O Q1j a bond Me a bond NH S a bond T3c OH
    3534 CMe O Q1j a bond Me a bond NH S a bond T3d OH
    3535 CMe O Q1j a bond Me a bond NH S a bond T3e OH
    3536 CMe O Q1j a bond Me a bond NH S a bond T3f OH
    3537 CMe O Q1j a bond Me a bond NH S a bond T3g OH
    3538 CMe O Q1j a bond Me a bond NH S a bond T3h OH
    3539 CMe O Q1j a bond Me a bond NH S a bond T3i OH
    3540 CMe O Q1j a bond Me a bond NH S a bond T3j OH
    3541 CMe O Q1j a bond Me a bond NH O NH T3a OH
    3542 CMe O Q1j a bond Me a bond NH O NH T3b OH
    3543 CMe O Q1j a bond Me a bond NH O NH T3c OH
    3544 CMe O Q1j a bond Me a bond NH O NH T3d OH
    3545 CMe O Q1j a bond Me a bond NH O NH T3e OH
    3546 CMe O Q1j a bond Me a bond NH O NH T3f OH
    3547 CMe O Q1j a bond Me a bond NH O NH T3g OH
    3548 CMe O Q1j a bond Me a bond NH O NH T3h OH
    3549 CMe O Q1j a bond Me a bond NH O NH T3i OH
    3550 CMe O Q1j a bond Me a bond NH O NH T3j OH
    3551 CMe O Q1j a bond Me a bond NH O a bond T3a OH
    3552 CMe O Q1j a bond Me a bond NH O a bond T3b OH
    3553 CMe O Q1j a bond Me a bond NH O a bond T3c OH
    3554 CMe O Q1j a bond Me a bond NH O a bond T3d OH
    3555 CMe O Q1j a bond Me a bond NH O a bond T3e OH
    3556 CMe O Q1j a bond Me a bond NH O a bond T3f OH
    3557 CMe O Q1j a bond Me a bond NH O a bond T3g OH
    3558 CMe O Q1j a bond Me a bond NH O a bond T3h OH
    3559 CMe O Q1j a bond Me a bond NH O a bond T3i OH
    3560 CMe O Q1j a bond Me a bond NH O a bond T3j OH
    3561 CMe O Q1j a bond H a bond NH S NH T3a OH
    3562 CMe O Q1j a bond H a bond NH S NH T3b OH
    3563 CMe O Q1j a bond H a bond NH S NH T3c OH
    3564 CMe O Q1j a bond H a bond NH S NH T3d OH
    3565 CMe O Q1j a bond H a bond NH S NH T3e OH
    3566 CMe O Q1j a bond H a bond NH S NH T3f OH
    3567 CMe O Q1j a bond H a bond NH S NH T3g OH
    3568 CMe O Q1j a bond H a bond NH S NH T3h OH
    3569 CMe O Q1j a bond H a bond NH S NH T3i OH
    3570 CMe O Q1j a bond H a bond NH S NH T3j OH
    3571 CMe O Q1j a bond H a bond NH S a bond T3a OH
    3572 CMe O Q1j a bond H a bond NH S a bond T3b OH
    3573 CMe O Q1j a bond H a bond NH S a bond T3c OH
    3574 CMe O Q1j a bond H a bond NH S a bond T3d OH
    3575 CMe O Q1j a bond H a bond NH S a bond T3e OH
    3576 CMe O Q1j a bond H a bond NH S a bond T3f OH
    3577 CMe O Q1j a bond H a bond NH S a bond T3g OH
    3578 CMe O Q1j a bond H a bond NH S a bond T3h OH
    3579 CMe O Q1j a bond H a bond NH S a bond T3i OH
    3580 CMe O Q1j a bond H a bond NH S a bond T3j OH
    3581 CMe O Q1j a bond H a bond NH O NH T3a OH
    3582 CMe O Q1j a bond H a bond NH O NH T3b OH
    3583 CMe O Q1j a bond H a bond NH O NH T3c OH
    3584 CMe O Q1j a bond H a bond NH O NH T3d OH
    3585 CMe O Q1j a bond H a bond NH O NH T3e OH
    3586 CMe O Q1j a bond H a bond NH O NH T3f OH
    3587 CMe O Q1j a bond H a bond NH O NH T3g OH
    3588 CMe O Q1j a bond H a bond NH O NH T3h OH
    3589 CMe O Q1j a bond H a bond NH O NH T3i OH
    3590 CMe O Q1j a bond H a bond NH O NH T3j OH
    3591 CMe O Q1j a bond H a bond NH O a bond T3a OH
    3592 CMe O Q1j a bond H a bond NH O a bond T3b OH
    3593 CMe O Q1j a bond H a bond NH O a bond T3c OH
    3594 CMe O Q1j a bond H a bond NH O a bond T3d OH
    3595 CMe O Q1j a bond H a bond NH O a bond T3e OH
    3596 CMe O Q1j a bond H a bond NH O a bond T3f OH
    3597 CMe O Q1j a bond H a bond NH O a bond T3g OH
    3598 CMe O Q1j a bond H a bond NH O a bond T3h OH
    3599 CMe O Q1j a bond H a bond NH O a bond T3i OH
    3600 CMe O Q1j a bond H a bond NH O a bond T3j OH
    3601 N NMe Q1i a bond Me a bond NH S NH Q3e OH
    3602 N NMe Q1i a bond Me a bond NH S a bond Q3e OH
    3603 N NMe Q1i a bond Me a bond NH O NH Q3e OH
    3604 N NMe Q1i a bond Me a bond NH O a bond Q3e OH
    3605 N NMe Q1i a bond H a bond NH S NH Q3e OH
    3606 N NMe Q1i a bond H a bond NH S a bond Q3e OH
    3607 N NMe Q1i a bond H a bond NH O NH Q3e OH
    3608 N NMe Q1i a bond H a bond NH O a bond Q3e OH
    3609 N NMe Q1j a bond Me a bond NH S NH Q3e OH
    3610 N NMe Q1j a bond Me a bond NH S a bond Q3e OH
    3611 N NMe Q1j a bond Me a bond NH O NH Q3e OH
    3612 N NMe Q1j a bond Me a bond NH O a bond Q3e OH
    3613 N NMe Q1j a bond H a bond NH S NH Q3e OH
    3614 N NMe Q1j a bond H a bond NH S a bond Q3e OH
    3615 N NMe Q1j a bond H a bond NH O NH Q3e OH
    3616 N NMe Q1j a bond H a bond NH O a bond Q3e OH
    3617 N S Q1i a bond Me a bond NH S NH Q3e OH
    3618 N S Q1i a bond Me a bond NH S a bond Q3e OH
    3619 N S Q1i a bond Me a bond NH O NH Q3e OH
    3620 N S Q1i a bond Me a bond NH O a bond Q3e OH
    3621 N S Q1i a bond H a bond NH S NH Q3e OH
    3622 N S Q1i a bond H a bond NH S a bond Q3e OH
    3623 N S Q1i a bond H a bond NH O NH Q3e OH
    3624 N S Q1i a bond H a bond NH O a bond Q3e OH
    3625 N S Q1j a bond Me a bond NH S NH Q3e OH
    3626 N S Q1j a bond Me a bond NH S a bond Q3e OH
    3627 N S Q1j a bond Me a bond NH O NH Q3e OH
    3628 N S Q1j a bond Me a bond NH O a bond Q3e OH
    3629 N S Q1j a bond H a bond NH S NH Q3e OH
    3630 N S Q1j a bond H a bond NH S a bond Q3e OH
    3631 N S Q1j a bond H a bond NH O NH Q3e OH
    3632 N S Q1j a bond H a bond NH O a bond Q3e OH
    3633 N O Q1i a bond Me a bond NH S NH Q3e OH
    3634 N O Q1i a bond Me a bond NH S a bond Q3e OH
    3635 N O Q1i a bond Me a bond NH O NH Q3e OH
    3636 N O Q1i a bond Me a bond NH O a bond Q3e OH
    3637 N O Q1i a bond H a bond NH S NH Q3e OH
    3638 N O Q1i a bond H a bond NH S a bond Q3e OH
    3639 N O Q1i a bond H a bond NH O NH Q3e OH
    3640 N O Q1i a bond H a bond NH O a bond Q3e OH
    3641 N O Q1j a bond Me a bond NH S NH Q3e OH
    3642 N O Q1j a bond Me a bond NH S a bond Q3e OH
    3643 N O Q1j a bond Me a bond NH O NH Q3e OH
    3644 N O Q1j a bond Me a bond NH O a bond Q3e OH
    3645 N O Q1j a bond H a bond NH S NH Q3e OH
    3646 N O Q1j a bond H a bond NH S a bond Q3e OH
    3647 N O Q1j a bond H a bond NH O NH Q3e OH
    3648 N O Q1j a bond H a bond NH O a bond Q3e OH
    3649 CH NMe Q1i a bond Me a bond NH S NH Q3e OH
    3650 CH NMe Q1i a bond Me a bond NH S a bond Q3e OH
    3651 CH NMe Q1i a bond Me a bond NH O NH Q3e OH
    3652 CH NMe Q1i a bond Me a bond NH O a bond Q3e OH
    3653 CH NMe Q1i a bond H a bond NH S NH Q3e OH
    3654 CH NMe Q1i a bond H a bond NH S a bond Q3e OH
    3655 CH NMe Q1i a bond H a bond NH O NH Q3e OH
    3656 CH NMe Q1i a bond H a bond NH O a bond Q3e OH
    3657 CH NMe Q1j a bond Me a bond NH S NH Q3e OH
    3658 CH NMe Q1j a bond Me a bond NH S a bond Q3e OH
    3659 CH NMe Q1j a bond Me a bond NH O NH Q3e OH
    3660 CH NMe Q1j a bond Me a bond NH O a bond Q3e OH
    3661 CH NMe Q1j a bond H a bond NH S NH Q3e OH
    3662 CH NMe Q1j a bond H a bond NH S a bond Q3e OH
    3663 CH NMe Q1j a bond H a bond NH O NH Q3e OH
    3664 CH NMe Q1j a bond H a bond NH O a bond Q3e OH
    3665 CH S Q1i a bond Me a bond NH S NH Q3e OH
    3666 CH S Q1i a bond Me a bond NH S a bond Q3e OH
    3667 CH S Q1i a bond Me a bond NH O NH Q3e OH
    3668 CH S Q1i a bond Me a bond NH O a bond Q3e OH
    3669 CH S Q1i a bond H a bond NH S NH Q3e OH
    3670 CH S Q1i a bond H a bond NH S a bond Q3e OH
    3671 CH S Q1i a bond H a bond NH O NH Q3e OH
    3672 CH S Q1i a bond H a bond NH O a bond Q3e OH
    3673 CH S Q1j a bond Me a bond NH S NH Q3e OH
    3674 CH S Q1j a bond Me a bond NH S a bond Q3e OH
    3675 CH S Q1j a bond Me a bond NH O NH Q3e OH
    3676 CH S Q1j a bond Me a bond NH O a bond Q3e OH
    3677 CH S Q1j a bond H a bond NH S NH Q3e OH
    3678 CH S Q1j a bond H a bond NH S a bond Q3e OH
    3679 CH S Q1j a bond H a bond NH O NH Q3e OH
    3680 CH S Q1j a bond H a bond NH O a bond Q3e OH
    3681 CH O Q1i a bond Me a bond NH S NH Q3e OH
    3682 CH O Q1i a bond Me a bond NH S a bond Q3e OH
    3683 CH O Q1i a bond Me a bond NH O NH Q3e OH
    3684 CH O Q1i a bond Me a bond NH O a bond Q3e OH
    3685 CH O Q1i a bond H a bond NH S NH Q3e OH
    3686 CH O Q1i a bond H a bond NH S a bond Q3e OH
    3687 CH O Q1i a bond H a bond NH O NH Q3e OH
    3688 CH O Q1i a bond H a bond NH O a bond Q3e OH
    3689 CH O Q1j a bond Me a bond NH S NH Q3e OH
    3690 CH O Q1j a bond Me a bond NH S a bond Q3e OH
    3691 CH O Q1j a bond Me a bond NH O NH Q3e OH
    3692 CH O Q1j a bond Me a bond NH O a bond Q3e OH
    3693 CH O Q1j a bond H a bond NH S NH Q3e OH
    3694 CH O Q1j a bond H a bond NH S a bond Q3e OH
    3695 CH O Q1j a bond H a bond NH O NH Q3e OH
    3696 CH O Q1j a bond H a bond NH O a bond Q3e OH
    3697 CMe NMe Q1i a bond Me a bond NH S NH Q3e OH
    3698 CMe NMe Q1i a bond Me a bond NH S a bond Q3e OH
    3699 CMe NMe Q1i a bond Me a bond NH O NH Q3e OH
    3700 CMe NMe Q1i a bond Me a bond NH O a bond Q3e OH
    3701 CMe NMe Q1i a bond H a bond NH S NH Q3e OH
    3702 CMe NMe Q1i a bond H a bond NH S a bond Q3e OH
    3703 CMe NMe Q1i a bond H a bond NH O NH Q3e OH
    3704 CMe NMe Q1i a bond H a bond NH O a bond Q3e OH
    3705 CMe NMe Q1j a bond Me a bond NH S NH Q3e OH
    3706 CMe NMe Q1j a bond Me a bond NH S a bond Q3e OH
    3707 CMe NMe Q1j a bond Me a bond NH O NH Q3e OH
    3708 CMe NMe Q1j a bond Me a bond NH O a bond Q3e OH
    3709 CMe NMe Q1j a bond H a bond NH S NH Q3e OH
    3710 CMe NMe Q1j a bond H a bond NH S a bond Q3e OH
    3711 CMe NMe Q1j a bond H a bond NH O NH Q3e OH
    3712 CMe NMe Q1j a bond H a bond NH O a bond Q3e OH
    3713 CMe S Q1i a bond Me a bond NH S NH Q3e OH
    3714 CMe S Q1i a bond Me a bond NH S a bond Q3e OH
    3715 CMe S Q1i a bond Me a bond NH O NH Q3e OH
    3716 CMe S Q1i a bond Me a bond NH O a bond Q3e OH
    3717 CMe S Q1i a bond H a bond NH S NH Q3e OH
    3718 CMe S Q1i a bond H a bond NH S a bond Q3e OH
    3719 CMe S Q1i a bond H a bond NH O NH Q3e OH
    3720 CMe S Q1i a bond H a bond NH O a bond Q3e OH
    3721 CMe S Q1j a bond Me a bond NH S NH Q3e OH
    3722 CMe S Q1j a bond Me a bond NH S a bond Q3e OH
    3723 CMe S Q1j a bond Me a bond NH O NH Q3e OH
    3724 CMe S Q1j a bond Me a bond NH O a bond Q3e OH
    3725 CMe S Q1j a bond H a bond NH S NH Q3e OH
    3726 CMe S Q1j a bond H a bond NH S a bond Q3e OH
    3727 CMe S Q1j a bond H a bond NH O NH Q3e OH
    3728 CMe S Q1j a bond H a bond NH O a bond Q3e OH
    3729 CMe O Q1i a bond Me a bond NH S NH Q3e OH
    3730 CMe O Q1i a bond Me a bond NH S a bond Q3e OH
    3731 CMe O Q1i a bond Me a bond NH O NH Q3e OH
    3732 CMe O Q1i a bond Me a bond NH O a bond Q3e OH
    3733 CMe O Q1i a bond H a bond NH S NH Q3e OH
    3734 CMe O Q1i a bond H a bond NH S a bond Q3e OH
    3735 CMe O Q1i a bond H a bond NH O NH Q3e OH
    3736 CMe O Q1i a bond H a bond NH O a bond Q3e OH
    3737 CMe O Q1j a bond Me a bond NH S NH Q3e OH
    3738 CMe O Q1j a bond Me a bond NH S a bond Q3e OH
    3739 CMe O Q1j a bond Me a bond NH O NH Q3e OH
    3740 CMe O Q1j a bond Me a bond NH O a bond Q3e OH
    3741 CMe O Q1j a bond H a bond NH S NH Q3e OH
    3742 CMe O Q1j a bond H a bond NH S a bond Q3e OH
    3743 CMe O Q1j a bond H a bond NH O NH Q3e OH
    3744 CMe O Q1j a bond H a bond NH O a bond Q3e OH
    3745 N NMe Q1o′ a bond Me a bond NH S NH Q3a OH
    3746 N NMe Q1o′ a bond Me a bond NH S NH Q3e OH
    3747 N NMe Q1o′ a bond Me a bond NH S NH T3a OH
    3748 N NMe Q1o′ a bond Me a bond NH S NH T3b OH
    3749 N NMe Q1o′ a bond Me a bond NH S NH T3c OH
    3750 N NMe Q1o′ a bond Me a bond NH S NH T3d OH
    3751 N NMe Q1o′ a bond Me a bond NH S NH T3e OH
    3752 N NMe Q1o′ a bond Me a bond NH S NH T3f OH
    3753 N NMe Q1o′ a bond Me a bond NH S NH T3g OH
    3754 N NMe Q1o′ a bond Me a bond NH S NH T3h OH
    3755 N NMe Q1o′ a bond Me a bond NH S NH T3i OH
    3756 N NMe Q1o′ a bond Me a bond NH S NH T3j OH
    3757 N NMe Q1o′ a bond Me a bond NH S a bond Q3a OH
    3758 N NMe Q1o′ a bond Me a bond NH S a bond Q3e OH
    3759 N NMe Q1o′ a bond Me a bond NH S a bond T3a OH
    3760 N NMe Q1o′ a bond Me a bond NH S a bond T3b OH
    3761 N NMe Q1o′ a bond Me a bond NH S a bond T3c OH
    3762 N NMe Q1o′ a bond Me a bond NH S a bond T3d OH
    3763 N NMe Q1o′ a bond Me a bond NH S a bond T3e OH
    3764 N NMe Q1o′ a bond Me a bond NH S a bond T3f OH
    3765 N NMe Q1o′ a bond Me a bond NH S a bond T3g OH
    3766 N NMe Q1o′ a bond Me a bond NH S a bond T3h OH
    3767 N NMe Q1o′ a bond Me a bond NH S a bond T3i OH
    3768 N NMe Q1o′ a bond Me a bond NH S a bond T3j OH
    3769 N NMe Q1o′ a bond Me a bond NH O NH Q3a OH
    3770 N NMe Q1o′ a bond Me a bond NH O NH Q3e OH
    3771 N NMe Q1o′ a bond Me a bond NH O NH T3a OH
    3772 N NMe Q1o′ a bond Me a bond NH O NH T3b OH
    3773 N NMe Q1o′ a bond Me a bond NH O NH T3c OH
    3774 N NMe Q1o′ a bond Me a bond NH O NH T3d OH
    3775 N NMe Q1o′ a bond Me a bond NH O NH T3e OH
    3776 N NMe Q1o′ a bond Me a bond NH O NH T3f OH
    3777 N NMe Q1o′ a bond Me a bond NH O NH T3g OH
    3778 N NMe Q1o′ a bond Me a bond NH O NH T3h OH
    3779 N NMe Q1o′ a bond Me a bond NH O NH T3i OH
    3780 N NMe Q1o′ a bond Me a bond NH O NH T3j OH
    3781 N NMe Q1o′ a bond Me a bond NH O a bond Q3a OH
    3782 N NMe Q1o′ a bond Me a bond NH O a bond Q3e OH
    3783 N NMe Q1o′ a bond Me a bond NH O a bond T3a OH
    3784 N NMe Q1o′ a bond Me a bond NH O a bond T3b OH
    3785 N NMe Q1o′ a bond Me a bond NH O a bond T3c OH
    3786 N NMe Q1o′ a bond Me a bond NH O a bond T3d OH
    3787 N NMe Q1o′ a bond Me a bond NH O a bond T3e OH
    3788 N NMe Q1o′ a bond Me a bond NH O a bond T3f OH
    3789 N NMe Q1o′ a bond Me a bond NH O a bond T3g OH
    3790 N NMe Q1o′ a bond Me a bond NH O a bond T3h OH
    3791 N NMe Q1o′ a bond Me a bond NH O a bond T3i OH
    3792 N NMe Q1o′ a bond Me a bond NH O a bond T3j OH
    3793 N NMe Q1o′ a bond H a bond NH S NH Q3a OH
    3794 N NMe Q1o′ a bond H a bond NH S NH Q3e OH
    3795 N NMe Q1o′ a bond H a bond NH S NH T3a OH
    3796 N NMe Q1o′ a bond H a bond NH S NH T3b OH
    3797 N NMe Q1o′ a bond H a bond NH S NH T3c OH
    3798 N NMe Q1o′ a bond H a bond NH S NH T3d OH
    3799 N NMe Q1o′ a bond H a bond NH S NH T3e OH
    3800 N NMe Q1o′ a bond H a bond NH S NH T3f OH
    3801 N NMe Q1o′ a bond H a bond NH S NH T3g OH
    3802 N NMe Q1o′ a bond H a bond NH S NH T3h OH
    3803 N NMe Q1o′ a bond H a bond NH S NH T3i OH
    3804 N NMe Q1o′ a bond H a bond NH S NH T3j OH
    3805 N NMe Q1o′ a bond H a bond NH S a bond Q3a OH
    3806 N NMe Q1o′ a bond H a bond NH S a bond Q3e OH
    3807 N NMe Q1o′ a bond H a bond NH S a bond T3a OH
    3808 N NMe Q1o′ a bond H a bond NH S a bond T3b OH
    3809 N NMe Q1o′ a bond H a bond NH S a bond T3c OH
    3810 N NMe Q1o′ a bond H a bond NH S a bond T3d OH
    3811 N NMe Q1o′ a bond H a bond NH S a bond T3e OH
    3812 N NMe Q1o′ a bond H a bond NH S a bond T3f OH
    3813 N NMe Q1o′ a bond H a bond NH S a bond T3g OH
    3814 N NMe Q1o′ a bond H a bond NH S a bond T3h OH
    3815 N NMe Q1o′ a bond H a bond NH S a bond T3i OH
    3816 N NMe Q1o′ a bond H a bond NH S a bond T3j OH
    3817 N NMe Q1o′ a bond H a bond NH O NH Q3a OH
    3818 N NMe Q1o′ a bond H a bond NH O NH Q3e OH
    3819 N NMe Q1o′ a bond H a bond NH O NH T3a OH
    3820 N NMe Q1o′ a bond H a bond NH O NH T3b OH
    3821 N NMe Q1o′ a bond H a bond NH O NH T3c OH
    3822 N NMe Q1o′ a bond H a bond NH O NH T3d OH
    3823 N NMe Q1o′ a bond H a bond NH O NH T3e OH
    3824 N NMe Q1o′ a bond H a bond NH O NH T3f OH
    3825 N NMe Q1o′ a bond H a bond NH O NH T3g OH
    3826 N NMe Q1o′ a bond H a bond NH O NH T3h OH
    3827 N NMe Q1o′ a bond H a bond NH O NH T3i OH
    3828 N NMe Q1o′ a bond H a bond NH O NH T3j OH
    3829 N NMe Q1o′ a bond H a bond NH O a bond Q3a OH
    3830 N NMe Q1o′ a bond H a bond NH O a bond Q3e OH
    3831 N NMe Q1o′ a bond H a bond NH O a bond T3a OH
    3832 N NMe Q1o′ a bond H a bond NH O a bond T3b OH
    3833 N NMe Q1o′ a bond H a bond NH O a bond T3c OH
    3834 N NMe Q1o′ a bond H a bond NH O a bond T3d OH
    3835 N NMe Q1o′ a bond H a bond NH O a bond T3e OH
    3836 N NMe Q1o′ a bond H a bond NH O a bond T3f OH
    3837 N NMe Q1o′ a bond H a bond NH O a bond T3g OH
    3838 N NMe Q1o′ a bond H a bond NH O a bond T3h OH
    3839 N NMe Q1o′ a bond H a bond NH O a bond T3i OH
    3840 N NMe Q1o′ a bond H a bond NH O a bond T3j OH
    3841 N S Q1o′ a bond Me a bond NH S NH Q3a OH
    3842 N S Q1o′ a bond Me a bond NH S NH Q3e OH
    3843 N S Q1o′ a bond Me a bond NH S NH T3a OH
    3844 N S Q1o′ a bond Me a bond NH S NH T3b OH
    3845 N S Q1o′ a bond Me a bond NH S NH T3c OH
    3846 N S Q1o′ a bond Me a bond NH S NH T3d OH
    3847 N S Q1o′ a bond Me a bond NH S NH T3e OH
    3848 N S Q1o′ a bond Me a bond NH S NH T3f OH
    3849 N S Q1o′ a bond Me a bond NH S NH T3g OH
    3850 N S Q1o′ a bond Me a bond NH S NH T3h OH
    3851 N S Q1o′ a bond Me a bond NH S NH T3i OH
    3852 N S Q1o′ a bond Me a bond NH S NH T3j OH
    3853 N S Q1o′ a bond Me a bond NH S a bond Q3a OH
    3854 N S Q1o′ a bond Me a bond NH S a bond Q3e OH
    3855 N S Q1o′ a bond Me a bond NH S a bond T3a OH
    3856 N S Q1o′ a bond Me a bond NH S a bond T3b OH
    3857 N S Q1o′ a bond Me a bond NH S a bond T3c OH
    3858 N S Q1o′ a bond Me a bond NH S a bond T3d OH
    3859 N S Q1o′ a bond Me a bond NH S a bond T3e OH
    3860 N S Q1o′ a bond Me a bond NH S a bond T3f OH
    3861 N S Q1o′ a bond Me a bond NH S a bond T3g OH
    3862 N S Q1o′ a bond Me a bond NH S a bond T3h OH
    3863 N S Q1o′ a bond Me a bond NH S a bond T3i OH
    3864 N S Q1o′ a bond Me a bond NH S a bond T3j OH
    3865 N S Q1o′ a bond Me a bond NH O NH Q3a OH
    3866 N S Q1o′ a bond Me a bond NH O NH Q3e OH
    3867 N S Q1o′ a bond Me a bond NH O NH T3a OH
    3868 N S Q1o′ a bond Me a bond NH O NH T3b OH
    3869 N S Q1o′ a bond Me a bond NH O NH T3c OH
    3870 N S Q1o′ a bond Me a bond NH O NH T3d OH
    3871 N S Q1o′ a bond Me a bond NH O NH T3e OH
    3872 N S Q1o′ a bond Me a bond NH O NH T3f OH
    3873 N S Q1o′ a bond Me a bond NH O NH T3g OH
    3874 N S Q1o′ a bond Me a bond NH O NH T3h OH
    3875 N S Q1o′ a bond Me a bond NH O NH T3i OH
    3876 N S Q1o′ a bond Me a bond NH O NH T3j OH
    3877 N S Q1o′ a bond Me a bond NH O a bond Q3a OH
    3878 N S Q1o′ a bond Me a bond NH O a bond Q3e OH
    3879 N S Q1o′ a bond Me a bond NH O a bond T3a OH
    3880 N S Q1o′ a bond Me a bond NH O a bond T3b OH
    3881 N S Q1o′ a bond Me a bond NH O a bond T3c OH
    3882 N S Q1o′ a bond Me a bond NH O a bond T3d OH
    3883 N S Q1o′ a bond Me a bond NH O a bond T3e OH
    3884 N S Q1o′ a bond Me a bond NH O a bond T3f OH
    3885 N S Q1o′ a bond Me a bond NH O a bond T3g OH
    3886 N S Q1o′ a bond Me a bond NH O a bond T3h OH
    3887 N S Q1o′ a bond Me a bond NH O a bond T3i OH
    3888 N S Q1o′ a bond Me a bond NH O a bond T3j OH
    3889 N S Q1o′ a bond H a bond NH S NH Q3a OH
    3890 N S Q1o′ a bond H a bond NH S NH Q3e OH
    3891 N S Q1o′ a bond H a bond NH S NH T3a OH
    3892 N S Q1o′ a bond H a bond NH S NH T3b OH
    3893 N S Q1o′ a bond H a bond NH S NH T3c OH
    3894 N S Q1o′ a bond H a bond NH S NH T3d OH
    3895 N S Q1o′ a bond H a bond NH S NH T3e OH
    3896 N S Q1o′ a bond H a bond NH S NH T3f OH
    3897 N S Q1o′ a bond H a bond NH S NH T3g OH
    3898 N S Q1o′ a bond H a bond NH S NH T3h OH
    3899 N S Q1o′ a bond H a bond NH S NH T3i OH
    3900 N S Q1o′ a bond H a bond NH S NH T3j OH
    3901 N S Q1o′ a bond H a bond NH S a bond Q3a OH
    3902 N S Q1o′ a bond H a bond NH S a bond Q3e OH
    3903 N S Q1o′ a bond H a bond NH S a bond T3a OH
    3904 N S Q1o′ a bond H a bond NH S a bond T3b OH
    3905 N S Q1o′ a bond H a bond NH S a bond T3c OH
    3906 N S Q1o′ a bond H a bond NH S a bond T3d OH
    3907 N S Q1o′ a bond H a bond NH S a bond T3e OH
    3908 N S Q1o′ a bond H a bond NH S a bond T3f OH
    3909 N S Q1o′ a bond H a bond NH S a bond T3g OH
    3910 N S Q1o′ a bond H a bond NH S a bond T3h OH
    3911 N S Q1o′ a bond H a bond NH S a bond T3i OH
    3912 N S Q1o′ a bond H a bond NH S a bond T3j OH
    3913 N S Q1o′ a bond H a bond NH O NH Q3a OH
    3914 N S Q1o′ a bond H a bond NH O NH Q3e OH
    3915 N S Q1o′ a bond H a bond NH O NH T3a OH
    3916 N S Q1o′ a bond H a bond NH O NH T3b OH
    3917 N S Q1o′ a bond H a bond NH O NH T3c OH
    3918 N S Q1o′ a bond H a bond NH O NH T3d OH
    3919 N S Q1o′ a bond H a bond NH O NH T3e OH
    3920 N S Q1o′ a bond H a bond NH O NH T3f OH
    3921 N S Q1o′ a bond H a bond NH O NH T3g OH
    3922 N S Q1o′ a bond H a bond NH O NH T3h OH
    3923 N S Q1o′ a bond H a bond NH O NH T3i OH
    3924 N S Q1o′ a bond H a bond NH O NH T3j OH
    3925 N S Q1o′ a bond H a bond NH O a bond Q3a OH
    3926 N S Q1o′ a bond H a bond NH O a bond Q3e OH
    3927 N S Q1o′ a bond H a bond NH O a bond T3a OH
    3928 N S Q1o′ a bond H a bond NH O a bond T3b OH
    3929 N S Q1o′ a bond H a bond NH O a bond T3c OH
    3930 N S Q1o′ a bond H a bond NH O a bond T3d OH
    3931 N S Q1o′ a bond H a bond NH O a bond T3e OH
    3932 N S Q1o′ a bond H a bond NH O a bond T3f OH
    3933 N S Q1o′ a bond H a bond NH O a bond T3g OH
    3934 N S Q1o′ a bond H a bond NH O a bond T3h OH
    3935 N S Q1o′ a bond H a bond NH O a bond T3i OH
    3936 N S Q1o′ a bond H a bond NH O a bond T3j OH
    3937 N O Q1o′ a bond Me a bond NH S NH Q3a OH
    3938 N O Q1o′ a bond Me a bond NH S NH Q3e OH
    3939 N O Q1o′ a bond Me a bond NH S NH T3a OH
    3940 N O Q1o′ a bond Me a bond NH S NH T3b OH
    3941 N O Q1o′ a bond Me a bond NH S NH T3c OH
    3942 N O Q1o′ a bond Me a bond NH S NH T3d OH
    3943 N O Q1o′ a bond Me a bond NH S NH T3e OH
    3944 N O Q1o′ a bond Me a bond NH S NH T3f OH
    3945 N O Q1o′ a bond Me a bond NH S NH T3g OH
    3946 N O Q1o′ a bond Me a bond NH S NH T3h OH
    3947 N O Q1o′ a bond Me a bond NH S NH T3i OH
    3948 N O Q1o′ a bond Me a bond NH S NH T3j OH
    3949 N O Q1o′ a bond Me a bond NH S a bond Q3a OH
    3950 N O Q1o′ a bond Me a bond NH S a bond Q3e OH
    3951 N O Q1o′ a bond Me a bond NH S a bond T3a OH
    3952 N O Q1o′ a bond Me a bond NH S a bond T3b OH
    3953 N O Q1o′ a bond Me a bond NH S a bond T3c OH
    3954 N O Q1o′ a bond Me a bond NH S a bond T3d OH
    3955 N O Q1o′ a bond Me a bond NH S a bond T3e OH
    3956 N O Q1o′ a bond Me a bond NH S a bond T3f OH
    3957 N O Q1o′ a bond Me a bond NH S a bond T3g OH
    3958 N O Q1o′ a bond Me a bond NH S a bond T3h OH
    3959 N O Q1o′ a bond Me a bond NH S a bond T3i OH
    3960 N O Q1o′ a bond Me a bond NH S a bond T3j OH
    3961 N O Q1o′ a bond Me a bond NH O NH Q3a OH
    3962 N O Q1o′ a bond Me a bond NH O NH Q3e OH
    3963 N O Q1o′ a bond Me a bond NH O NH T3a OH
    3964 N O Q1o′ a bond Me a bond NH O NH T3b OH
    3965 N O Q1o′ a bond Me a bond NH O NH T3c OH
    3966 N O Q1o′ a bond Me a bond NH O NH T3d OH
    3967 N O Q1o′ a bond Me a bond NH O NH T3e OH
    3968 N O Q1o′ a bond Me a bond NH O NH T3f OH
    3969 N O Q1o′ a bond Me a bond NH O NH T3g OH
    3970 N O Q1o′ a bond Me a bond NH O NH T3h OH
    3971 N O Q1o′ a bond Me a bond NH O NH T3i OH
    3972 N O Q1o′ a bond Me a bond NH O NH T3j OH
    3973 N O Q1o′ a bond Me a bond NH O a bond Q3a OH
    3974 N O Q1o′ a bond Me a bond NH O a bond Q3e OH
    3975 N O Q1o′ a bond Me a bond NH O a bond T3a OH
    3976 N O Q1o′ a bond Me a bond NH O a bond T3b OH
    3977 N O Q1o′ a bond Me a bond NH O a bond T3c OH
    3978 N O Q1o′ a bond Me a bond NH O a bond T3d OH
    3979 N O Q1o′ a bond Me a bond NH O a bond T3e OH
    3980 N O Q1o′ a bond Me a bond NH O a bond T3f OH
    3981 N O Q1o′ a bond Me a bond NH O a bond T3g OH
    3982 N O Q1o′ a bond Me a bond NH O a bond T3h OH
    3983 N O Q1o′ a bond Me a bond NH O a bond T3i OH
    3984 N O Q1o′ a bond Me a bond NH O a bond T3j OH
    3985 N O Q1o′ a bond H a bond NH S NH Q3a OH
    3986 N O Q1o′ a bond H a bond NH S NH Q3e OH
    3987 N O Q1o′ a bond H a bond NH S NH T3a OH
    3988 N O Q1o′ a bond H a bond NH S NH T3b OH
    3989 N O Q1o′ a bond H a bond NH S NH T3c OH
    3990 N O Q1o′ a bond H a bond NH S NH T3d OH
    3991 N O Q1o′ a bond H a bond NH S NH T3e OH
    3992 N O Q1o′ a bond H a bond NH S NH T3f OH
    3993 N O Q1o′ a bond H a bond NH S NH T3g OH
    3994 N O Q1o′ a bond H a bond NH S NH T3h OH
    3995 N O Q1o′ a bond H a bond NH S NH T3i OH
    3996 N O Q1o′ a bond H a bond NH S NH T3j OH
    3997 N O Q1o′ a bond H a bond NH S a bond Q3a OH
    3998 N O Q1o′ a bond H a bond NH S a bond Q3e OH
    3999 N O Q1o′ a bond H a bond NH S a bond T3a OH
    4000 N O Q1o′ a bond H a bond NH S a bond T3b OH
    4001 N O Q1o′ a bond H a bond NH S a bond T3c OH
    4002 N O Q1o′ a bond H a bond NH S a bond T3d OH
    4003 N O Q1o′ a bond H a bond NH S a bond T3e OH
    4004 N O Q1o′ a bond H a bond NH S a bond T3f OH
    4005 N O Q1o′ a bond H a bond NH S a bond T3g OH
    4006 N O Q1o′ a bond H a bond NH S a bond T3h OH
    4007 N O Q1o′ a bond H a bond NH S a bond T3i OH
    4008 N O Q1o′ a bond H a bond NH S a bond T3j OH
    4009 N O Q1o′ a bond H a bond NH O NH Q3a OH
    4010 N O Q1o′ a bond H a bond NH O NH Q3e OH
    4011 N O Q1o′ a bond H a bond NH O NH T3a OH
    4012 N O Q1o′ a bond H a bond NH O NH T3b OH
    4013 N O Q1o′ a bond H a bond NH O NH T3c OH
    4014 N O Q1o′ a bond H a bond NH O NH T3d OH
    4015 N O Q1o′ a bond H a bond NH O NH T3e OH
    4016 N O Q1o′ a bond H a bond NH O NH T3f OH
    4017 N O Q1o′ a bond H a bond NH O NH T3g OH
    4018 N O Q1o′ a bond H a bond NH O NH T3h OH
    4019 N O Q1o′ a bond H a bond NH O NH T3i OH
    4020 N O Q1o′ a bond H a bond NH O NH T3j OH
    4021 N O Q1o′ a bond H a bond NH O a bond Q3a OH
    4022 N O Q1o′ a bond H a bond NH O a bond Q3e OH
    4023 N O Q1o′ a bond H a bond NH O a bond T3a OH
    4024 N O Q1o′ a bond H a bond NH O a bond T3b OH
    4025 N O Q1o′ a bond H a bond NH O a bond T3c OH
    4026 N O Q1o′ a bond H a bond NH O a bond T3d OH
    4027 N O Q1o′ a bond H a bond NH O a bond T3e OH
    4028 N O Q1o′ a bond H a bond NH O a bond T3f OH
    4029 N O Q1o′ a bond H a bond NH O a bond T3g OH
    4030 N O Q1o′ a bond H a bond NH O a bond T3h OH
    4031 N O Q1o′ a bond H a bond NH O a bond T3i OH
    4032 N O Q1o′ a bond H a bond NH O a bond T3j OH
    4033 CH NMe Q1o′ a bond Me a bond NH S NH Q3a OH
    4034 CH NMe Q1o′ a bond Me a bond NH S NH Q3e OH
    4035 CH NMe Q1o′ a bond Me a bond NH S NH T3a OH
    4036 CH NMe Q1o′ a bond Me a bond NH S NH T3b OH
    4037 CH NMe Q1o′ a bond Me a bond NH S NH T3c OH
    4038 CH NMe Q1o′ a bond Me a bond NH S NH T3d OH
    4039 CH NMe Q1o′ a bond Me a bond NH S NH T3e OH
    4040 CH NMe Q1o′ a bond Me a bond NH S NH T3f OH
    4041 CH NMe Q1o′ a bond Me a bond NH S NH T3g OH
    4042 CH NMe Q1o′ a bond Me a bond NH S NH T3h OH
    4043 CH NMe Q1o′ a bond Me a bond NH S NH T3i OH
    4044 CH NMe Q1o′ a bond Me a bond NH S NH T3j OH
    4045 CH NMe Q1o′ a bond Me a bond NH S a bond Q3a OH
    4046 CH NMe Q1o′ a bond Me a bond NH S a bond Q3e OH
    4047 CH NMe Q1o′ a bond Me a bond NH S a bond T3a OH
    4048 CH NMe Q1o′ a bond Me a bond NH S a bond T3b OH
    4049 CH NMe Q1o′ a bond Me a bond NH S a bond T3c OH
    4050 CH NMe Q1o′ a bond Me a bond NH S a bond T3d OH
    4051 CH NMe Q1o′ a bond Me a bond NH S a bond T3e OH
    4052 CH NMe Q1o′ a bond Me a bond NH S a bond T3f OH
    4053 CH NMe Q1o′ a bond Me a bond NH S a bond T3g OH
    4054 CH NMe Q1o′ a bond Me a bond NH S a bond T3h OH
    4055 CH NMe Q1o′ a bond Me a bond NH S a bond T3i OH
    4056 CH NMe Q1o′ a bond Me a bond NH S a bond T3j OH
    4057 CH NMe Q1o′ a bond Me a bond NH O NH Q3a OH
    4058 CH NMe Q1o′ a bond Me a bond NH O NH Q3e OH
    4059 CH NMe Q1o′ a bond Me a bond NH O NH T3a OH
    4060 CH NMe Q1o′ a bond Me a bond NH O NH T3b OH
    4061 CH NMe Q1o′ a bond Me a bond NH O NH T3c OH
    4062 CH NMe Q1o′ a bond Me a bond NH O NH T3d OH
    4063 CH NMe Q1o′ a bond Me a bond NH O NH T3e OH
    4064 CH NMe Q1o′ a bond Me a bond NH O NH T3f OH
    4065 CH NMe Q1o′ a bond Me a bond NH O NH T3g OH
    4066 CH NMe Q1o′ a bond Me a bond NH O NH T3h OH
    4067 CH NMe Q1o′ a bond Me a bond NH O NH T3i OH
    4068 CH NMe Q1o′ a bond Me a bond NH O NH T3j OH
    4069 CH NMe Q1o′ a bond Me a bond NH O a bond Q3a OH
    4070 CH NMe Q1o′ a bond Me a bond NH O a bond Q3e OH
    4071 CH NMe Q1o′ a bond Me a bond NH O a bond T3a OH
    4072 CH NMe Q1o′ a bond Me a bond NH O a bond T3b OH
    4073 CH NMe Q1o′ a bond Me a bond NH O a bond T3c OH
    4074 CH NMe Q1o′ a bond Me a bond NH O a bond T3d OH
    4075 CH NMe Q1o′ a bond Me a bond NH O a bond T3e OH
    4076 CH NMe Q1o′ a bond Me a bond NH O a bond T3f OH
    4077 CH NMe Q1o′ a bond Me a bond NH O a bond T3g OH
    4078 CH NMe Q1o′ a bond Me a bond NH O a bond T3h OH
    4079 CH NMe Q1o′ a bond Me a bond NH O a bond T3i OH
    4080 CH NMe Q1o′ a bond Me a bond NH O a bond T3j OH
    4081 CH NMe Q1o′ a bond H a bond NH S NH Q3a OH
    4082 CH NMe Q1o′ a bond H a bond NH S NH Q3e OH
    4083 CH NMe Q1o′ a bond H a bond NH S NH T3a OH
    4084 CH NMe Q1o′ a bond H a bond NH S NH T3b OH
    4085 CH NMe Q1o′ a bond H a bond NH S NH T3c OH
    4086 CH NMe Q1o′ a bond H a bond NH S NH T3d OH
    4087 CH NMe Q1o′ a bond H a bond NH S NH T3e OH
    4088 CH NMe Q1o′ a bond H a bond NH S NH T3f OH
    4089 CH NMe Q1o′ a bond H a bond NH S NH T3g OH
    4090 CH NMe Q1o′ a bond H a bond NH S NH T3h OH
    4091 CH NMe Q1o′ a bond H a bond NH S NH T3i OH
    4092 CH NMe Q1o′ a bond H a bond NH S NH T3j OH
    4093 CH NMe Q1o′ a bond H a bond NH S a bond Q3a OH
    4094 CH NMe Q1o′ a bond H a bond NH S a bond Q3e OH
    4095 CH NMe Q1o′ a bond H a bond NH S a bond T3a OH
    4096 CH NMe Q1o′ a bond H a bond NH S a bond T3b OH
    4097 CH NMe Q1o′ a bond H a bond NH S a bond T3c OH
    4098 CH NMe Q1o′ a bond H a bond NH S a bond T3d OH
    4099 CH NMe Q1o′ a bond H a bond NH S a bond T3e OH
    4100 CH NMe Q1o′ a bond H a bond NH S a bond T3f OH
    4101 CH NMe Q1o′ a bond H a bond NH S a bond T3g OH
    4102 CH NMe Q1o′ a bond H a bond NH S a bond T3h OH
    4103 CH NMe Q1o′ a bond H a bond NH S a bond T3i OH
    4104 CH NMe Q1o′ a bond H a bond NH S a bond T3j OH
    4105 CH NMe Q1o′ a bond H a bond NH O NH Q3a OH
    4106 CH NMe Q1o′ a bond H a bond NH O NH Q3e OH
    4107 CH NMe Q1o′ a bond H a bond NH O NH T3a OH
    4108 CH NMe Q1o′ a bond H a bond NH O NH T3b OH
    4109 CH NMe Q1o′ a bond H a bond NH O NH T3c OH
    4110 CH NMe Q1o′ a bond H a bond NH O NH T3d OH
    4111 CH NMe Q1o′ a bond H a bond NH O NH T3e OH
    4112 CH NMe Q1o′ a bond H a bond NH O NH T3f OH
    4113 CH NMe Q1o′ a bond H a bond NH O NH T3g OH
    4114 CH NMe Q1o′ a bond H a bond NH O NH T3h OH
    4115 CH NMe Q1o′ a bond H a bond NH O NH T3i OH
    4116 CH NMe Q1o′ a bond H a bond NH O NH T3j OH
    4117 CH NMe Q1o′ a bond H a bond NH O a bond Q3a OH
    4118 CH NMe Q1o′ a bond H a bond NH O a bond Q3e OH
    4119 CH NMe Q1o′ a bond H a bond NH O a bond T3a OH
    4120 CH NMe Q1o′ a bond H a bond NH O a bond T3b OH
    4121 CH NMe Q1o′ a bond H a bond NH O a bond T3c OH
    4122 CH NMe Q1o′ a bond H a bond NH O a bond T3d OH
    4123 CH NMe Q1o′ a bond H a bond NH O a bond T3e OH
    4124 CH NMe Q1o′ a bond H a bond NH O a bond T3f OH
    4125 CH NMe Q1o′ a bond H a bond NH O a bond T3g OH
    4126 CH NMe Q1o′ a bond H a bond NH O a bond T3h OH
    4127 CH NMe Q1o′ a bond H a bond NH O a bond T3i OH
    4128 CH NMe Q1o′ a bond H a bond NH O a bond T3j OH
    4129 CH S Q1o′ a bond Me a bond NH S NH Q3a OH
    4130 CH S Q1o′ a bond Me a bond NH S NH Q3e OH
    4131 CH S Q1o′ a bond Me a bond NH S NH T3a OH
    4132 CH S Q1o′ a bond Me a bond NH S NH T3b OH
    4133 CH S Q1o′ a bond Me a bond NH S NH T3c OH
    4134 CH S Q1o′ a bond Me a bond NH S NH T3d OH
    4135 CH S Q1o′ a bond Me a bond NH S NH T3e OH
    4136 CH S Q1o′ a bond Me a bond NH S NH T3f OH
    4137 CH S Q1o′ a bond Me a bond NH S NH T3g OH
    4138 CH S Q1o′ a bond Me a bond NH S NH T3h OH
    4139 CH S Q1o′ a bond Me a bond NH S NH T3i OH
    4140 CH S Q1o′ a bond Me a bond NH S NH T3j OH
    4141 CH S Q1o′ a bond Me a bond NH S a bond Q3a OH
    4142 CH S Q1o′ a bond Me a bond NH S a bond Q3e OH
    4143 CH S Q1o′ a bond Me a bond NH S a bond T3a OH
    4144 CH S Q1o′ a bond Me a bond NH S a bond T3b OH
    4145 CH S Q1o′ a bond Me a bond NH S a bond T3c OH
    4146 CH S Q1o′ a bond Me a bond NH S a bond T3d OH
    4147 CH S Q1o′ a bond Me a bond NH S a bond T3e OH
    4148 CH S Q1o′ a bond Me a bond NH S a bond T3f OH
    4149 CH S Q1o′ a bond Me a bond NH S a bond T3g OH
    4150 CH S Q1o′ a bond Me a bond NH S a bond T3h OH
    4151 CH S Q1o′ a bond Me a bond NH S a bond T3i OH
    4152 CH S Q1o′ a bond Me a bond NH S a bond T3j OH
    4153 CH S Q1o′ a bond Me a bond NH O NH Q3a OH
    4154 CH S Q1o′ a bond Me a bond NH O NH Q3e OH
    4155 CH S Q1o′ a bond Me a bond NH O NH T3a OH
    4156 CH S Q1o′ a bond Me a bond NH O NH T3b OH
    4157 CH S Q1o′ a bond Me a bond NH O NH T3c OH
    4158 CH S Q1o′ a bond Me a bond NH O NH T3d OH
    4159 CH S Q1o′ a bond Me a bond NH O NH T3e OH
    4160 CH S Q1o′ a bond Me a bond NH O NH T3f OH
    4161 CH S Q1o′ a bond Me a bond NH O NH T3g OH
    4162 CH S Q1o′ a bond Me a bond NH O NH T3h OH
    4163 CH S Q1o′ a bond Me a bond NH O NH T3i OH
    4164 CH S Q1o′ a bond Me a bond NH O NH T3j OH
    4165 CH S Q1o′ a bond Me a bond NH O a bond Q3a OH
    4166 CH S Q1o′ a bond Me a bond NH O a bond Q3e OH
    4167 CH S Q1o′ a bond Me a bond NH O a bond T3a OH
    4168 CH S Q1o′ a bond Me a bond NH O a bond T3b OH
    4169 CH S Q1o′ a bond Me a bond NH O a bond T3c OH
    4170 CH S Q1o′ a bond Me a bond NH O a bond T3d OH
    4171 CH S Q1o′ a bond Me a bond NH O a bond T3e OH
    4172 CH S Q1o′ a bond Me a bond NH O a bond T3f OH
    4173 CH S Q1o′ a bond Me a bond NH O a bond T3g OH
    4174 CH S Q1o′ a bond Me a bond NH O a bond T3h OH
    4175 CH S Q1o′ a bond Me a bond NH O a bond T3i OH
    4176 CH S Q1o′ a bond Me a bond NH O a bond T3j OH
    4177 CH S Q1o′ a bond H a bond NH S NH Q3a OH
    4178 CH S Q1o′ a bond H a bond NH S NH Q3e OH
    4179 CH S Q1o′ a bond H a bond NH S NH T3a OH
    4180 CH S Q1o′ a bond H a bond NH S NH T3b OH
    4181 CH S Q1o′ a bond H a bond NH S NH T3c OH
    4182 CH S Q1o′ a bond H a bond NH S NH T3d OH
    4183 CH S Q1o′ a bond H a bond NH S NH T3e OH
    4184 CH S Q1o′ a bond H a bond NH S NH T3f OH
    4185 CH S Q1o′ a bond H a bond NH S NH T3g OH
    4186 CH S Q1o′ a bond H a bond NH S NH T3h OH
    4187 CH S Q1o′ a bond H a bond NH S NH T3i OH
    4188 CH S Q1o′ a bond H a bond NH S NH T3j OH
    4189 CH S Q1o′ a bond H a bond NH S a bond Q3a OH
    4190 CH S Q1o′ a bond H a bond NH S a bond Q3e OH
    4191 CH S Q1o′ a bond H a bond NH S a bond T3a OH
    4192 CH S Q1o′ a bond H a bond NH S a bond T3b OH
    4193 CH S Q1o′ a bond H a bond NH S a bond T3c OH
    4194 CH S Q1o′ a bond H a bond NH S a bond T3d OH
    4195 CH S Q1o′ a bond H a bond NH S a bond T3e OH
    4196 CH S Q1o′ a bond H a bond NH S a bond T3f OH
    4197 CH S Q1o′ a bond H a bond NH S a bond T3g OH
    4198 CH S Q1o′ a bond H a bond NH S a bond T3h OH
    4199 CH S Q1o′ a bond H a bond NH S a bond T3i OH
    4200 CH S Q1o′ a bond H a bond NH S a bond T3j OH
    4201 CH S Q1o′ a bond H a bond NH O NH Q3a OH
    4202 CH S Q1o′ a bond H a bond NH O NH Q3e OH
    4203 CH S Q1o′ a bond H a bond NH O NH T3a OH
    4204 CH S Q1o′ a bond H a bond NH O NH T3b OH
    4205 CH S Q1o′ a bond H a bond NH O NH T3c OH
    4206 CH S Q1o′ a bond H a bond NH O NH T3d OH
    4207 CH S Q1o′ a bond H a bond NH O NH T3e OH
    4208 CH S Q1o′ a bond H a bond NH O NH T3f OH
    4209 CH S Q1o′ a bond H a bond NH O NH T3g OH
    4210 CH S Q1o′ a bond H a bond NH O NH T3h OH
    4211 CH S Q1o′ a bond H a bond NH O NH T3i OH
    4212 CH S Q1o′ a bond H a bond NH O NH T3j OH
    4213 CH S Q1o′ a bond H a bond NH O a bond Q3a OH
    4214 CH S Q1o′ a bond H a bond NH O a bond Q3e OH
    4215 CH S Q1o′ a bond H a bond NH O a bond T3a OH
    4216 CH S Q1o′ a bond H a bond NH O a bond T3b OH
    4217 CH S Q1o′ a bond H a bond NH O a bond T3c OH
    4218 CH S Q1o′ a bond H a bond NH O a bond T3d OH
    4219 CH S Q1o′ a bond H a bond NH O a bond T3e OH
    4220 CH S Q1o′ a bond H a bond NH O a bond T3f OH
    4221 CH S Q1o′ a bond H a bond NH O a bond T3g OH
    4222 CH S Q1o′ a bond H a bond NH O a bond T3h OH
    4223 CH S Q1o′ a bond H a bond NH O a bond T3i OH
    4224 CH S Q1o′ a bond H a bond NH O a bond T3j OH
    4225 CH O Q1o′ a bond Me a bond NH S NH Q3a OH
    4226 CH O Q1o′ a bond Me a bond NH S NH Q3e OH
    4227 CH O Q1o′ a bond Me a bond NH S NH T3a OH
    4228 CH O Q1o′ a bond Me a bond NH S NH T3b OH
    4229 CH O Q1o′ a bond Me a bond NH S NH T3c OH
    4230 CH O Q1o′ a bond Me a bond NH S NH T3d OH
    4231 CH O Q1o′ a bond Me a bond NH S NH T3e OH
    4232 CH O Q1o′ a bond Me a bond NH S NH T3f OH
    4233 CH O Q1o′ a bond Me a bond NH S NH T3g OH
    4234 CH O Q1o′ a bond Me a bond NH S NH T3h OH
    4235 CH O Q1o′ a bond Me a bond NH S NH T3i OH
    4236 CH O Q1o′ a bond Me a bond NH S NH T3j OH
    4237 CH O Q1o′ a bond Me a bond NH S a bond Q3a OH
    4238 CH O Q1o′ a bond Me a bond NH S a bond Q3e OH
    4239 CH O Q1o′ a bond Me a bond NH S a bond T3a OH
    4240 CH O Q1o′ a bond Me a bond NH S a bond T3b OH
    4241 CH O Q1o′ a bond Me a bond NH S a bond T3c OH
    4242 CH O Q1o′ a bond Me a bond NH S a bond T3d OH
    4243 CH O Q1o′ a bond Me a bond NH S a bond T3e OH
    4244 CH O Q1o′ a bond Me a bond NH S a bond T3f OH
    4245 CH O Q1o′ a bond Me a bond NH S a bond T3g OH
    4246 CH O Q1o′ a bond Me a bond NH S a bond T3h OH
    4247 CH O Q1o′ a bond Me a bond NH S a bond T3i OH
    4248 CH O Q1o′ a bond Me a bond NH S a bond T3j OH
    4249 CH O Q1o′ a bond Me a bond NH O NH Q3a OH
    4250 CH O Q1o′ a bond Me a bond NH O NH Q3e OH
    4251 CH O Q1o′ a bond Me a bond NH O NH T3a OH
    4252 CH O Q1o′ a bond Me a bond NH O NH T3b OH
    4253 CH O Q1o′ a bond Me a bond NH O NH T3c OH
    4254 CH O Q1o′ a bond Me a bond NH O NH T3d OH
    4255 CH O Q1o′ a bond Me a bond NH O NH T3e OH
    4256 CH O Q1o′ a bond Me a bond NH O NH T3f OH
    4257 CH O Q1o′ a bond Me a bond NH O NH T3g OH
    4258 CH O Q1o′ a bond Me a bond NH O NH T3h OH
    4259 CH O Q1o′ a bond Me a bond NH O NH T3i OH
    4260 CH O Q1o′ a bond Me a bond NH O NH T3j OH
    4261 CH O Q1o′ a bond Me a bond NH O a bond Q3a OH
    4262 CH O Q1o′ a bond Me a bond NH O a bond Q3e OH
    4263 CH O Q1o′ a bond Me a bond NH O a bond T3a OH
    4264 CH O Q1o′ a bond Me a bond NH O a bond T3b OH
    4265 CH O Q1o′ a bond Me a bond NH O a bond T3c OH
    4266 CH O Q1o′ a bond Me a bond NH O a bond T3d OH
    4267 CH O Q1o′ a bond Me a bond NH O a bond T3e OH
    4268 CH O Q1o′ a bond Me a bond NH O a bond T3f OH
    4269 CH O Q1o′ a bond Me a bond NH O a bond T3g OH
    4270 CH O Q1o′ a bond Me a bond NH O a bond T3h OH
    4271 CH O Q1o′ a bond Me a bond NH O a bond T3i OH
    4272 CH O Q1o′ a bond Me a bond NH O a bond T3j OH
    4273 CH O Q1o′ a bond H a bond NH S NH Q3a OH
    4274 CH O Q1o′ a bond H a bond NH S NH Q3e OH
    4275 CH O Q1o′ a bond H a bond NH S NH T3a OH
    4276 CH O Q1o′ a bond H a bond NH S NH T3b OH
    4277 CH O Q1o′ a bond H a bond NH S NH T3c OH
    4278 CH O Q1o′ a bond H a bond NH S NH T3d OH
    4279 CH O Q1o′ a bond H a bond NH S NH T3e OH
    4280 CH O Q1o′ a bond H a bond NH S NH T3f OH
    4281 CH O Q1o′ a bond H a bond NH S NH T3g OH
    4282 CH O Q1o′ a bond H a bond NH S NH T3h OH
    4283 CH O Q1o′ a bond H a bond NH S NH T3i OH
    4284 CH O Q1o′ a bond H a bond NH S NH T3j OH
    4285 CH O Q1o′ a bond H a bond NH S a bond Q3a OH
    4286 CH O Q1o′ a bond H a bond NH S a bond Q3e OH
    4287 CH O Q1o′ a bond H a bond NH S a bond T3a OH
    4288 CH O Q1o′ a bond H a bond NH S a bond T3b OH
    4289 CH O Q1o′ a bond H a bond NH S a bond T3c OH
    4290 CH O Q1o′ a bond H a bond NH S a bond T3d OH
    4291 CH O Q1o′ a bond H a bond NH S a bond T3e OH
    4292 CH O Q1o′ a bond H a bond NH S a bond T3f OH
    4293 CH O Q1o′ a bond H a bond NH S a bond T3g OH
    4294 CH O Q1o′ a bond H a bond NH S a bond T3h OH
    4295 CH O Q1o′ a bond H a bond NH S a bond T3i OH
    4296 CH O Q1o′ a bond H a bond NH S a bond T3j OH
    4297 CH O Q1o′ a bond H a bond NH O NH Q3a OH
    4298 CH O Q1o′ a bond H a bond NH O NH Q3e OH
    4299 CH O Q1o′ a bond H a bond NH O NH T3a OH
    4300 CH O Q1o′ a bond H a bond NH O NH T3b OH
    4301 CH O Q1o′ a bond H a bond NH O NH T3c OH
    4302 CH O Q1o′ a bond H a bond NH O NH T3d OH
    4303 CH O Q1o′ a bond H a bond NH O NH T3e OH
    4304 CH O Q1o′ a bond H a bond NH O NH T3f OH
    4305 CH O Q1o′ a bond H a bond NH O NH T3g OH
    4306 CH O Q1o′ a bond H a bond NH O NH T3h OH
    4307 CH O Q1o′ a bond H a bond NH O NH T3i OH
    4308 CH O Q1o′ a bond H a bond NH O NH T3j OH
    4309 CH O Q1o′ a bond H a bond NH O a bond Q3a OH
    4310 CH O Q1o′ a bond H a bond NH O a bond Q3e OH
    4311 CH O Q1o′ a bond H a bond NH O a bond T3a OH
    4312 CH O Q1o′ a bond H a bond NH O a bond T3b OH
    4313 CH O Q1o′ a bond H a bond NH O a bond T3c OH
    4314 CH O Q1o′ a bond H a bond NH O a bond T3d OH
    4315 CH O Q1o′ a bond H a bond NH O a bond T3e OH
    4316 CH O Q1o′ a bond H a bond NH O a bond T3f OH
    4317 CH O Q1o′ a bond H a bond NH O a bond T3g OH
    4318 CH O Q1o′ a bond H a bond NH O a bond T3h OH
    4319 CH O Q1o′ a bond H a bond NH O a bond T3i OH
    4320 CH O Q1o′ a bond H a bond NH O a bond T3j OH
    4321 CMe NMe Q1o′ a bond Me a bond NH S NH Q3a OH
    4322 CMe NMe Q1o′ a bond Me a bond NH S NH Q3e OH
    4323 CMe NMe Q1o′ a bond Me a bond NH S NH T3a OH
    4324 CMe NMe Q1o′ a bond Me a bond NH S NH T3b OH
    4325 CMe NMe Q1o′ a bond Me a bond NH S NH T3c OH
    4326 CMe NMe Q1o′ a bond Me a bond NH S NH T3d OH
    4327 CMe NMe Q1o′ a bond Me a bond NH S NH T3e OH
    4328 CMe NMe Q1o′ a bond Me a bond NH S NH T3f OH
    4329 CMe NMe Q1o′ a bond Me a bond NH S NH T3g OH
    4330 CMe NMe Q1o′ a bond Me a bond NH S NH T3h OH
    4331 CMe NMe Q1o′ a bond Me a bond NH S NH T3i OH
    4332 CMe NMe Q1o′ a bond Me a bond NH S NH T3j OH
    4333 CMe NMe Q1o′ a bond Me a bond NH S a bond Q3a OH
    4334 CMe NMe Q1o′ a bond Me a bond NH S a bond Q3e OH
    4335 CMe NMe Q1o′ a bond Me a bond NH S a bond T3a OH
    4336 CMe NMe Q1o′ a bond Me a bond NH S a bond T3b OH
    4337 CMe NMe Q1o′ a bond Me a bond NH S a bond T3c OH
    4338 CMe NMe Q1o′ a bond Me a bond NH S a bond T3d OH
    4339 CMe NMe Q1o′ a bond Me a bond NH S a bond T3e OH
    4340 CMe NMe Q1o′ a bond Me a bond NH S a bond T3f OH
    4341 CMe NMe Q1o′ a bond Me a bond NH S a bond T3g OH
    4342 CMe NMe Q1o′ a bond Me a bond NH S a bond T3h OH
    4343 CMe NMe Q1o′ a bond Me a bond NH S a bond T3i OH
    4344 CMe NMe Q1o′ a bond Me a bond NH S a bond T3j OH
    4345 CMe NMe Q1o′ a bond Me a bond NH O NH Q3a OH
    4346 CMe NMe Q1o′ a bond Me a bond NH O NH Q3e OH
    4347 CMe NMe Q1o′ a bond Me a bond NH O NH T3a OH
    4348 CMe NMe Q1o′ a bond Me a bond NH O NH T3b OH
    4349 CMe NMe Q1o′ a bond Me a bond NH O NH T3c OH
    4350 CMe NMe Q1o′ a bond Me a bond NH O NH T3d OH
    4351 CMe NMe Q1o′ a bond Me a bond NH O NH T3e OH
    4352 CMe NMe Q1o′ a bond Me a bond NH O NH T3f OH
    4353 CMe NMe Q1o′ a bond Me a bond NH O NH T3g OH
    4354 CMe NMe Q1o′ a bond Me a bond NH O NH T3h OH
    4355 CMe NMe Q1o′ a bond Me a bond NH O NH T3i OH
    4356 CMe NMe Q1o′ a bond Me a bond NH O NH T3j OH
    4357 CMe NMe Q1o′ a bond Me a bond NH O a bond Q3a OH
    4358 CMe NMe Q1o′ a bond Me a bond NH O a bond Q3e OH
    4359 CMe NMe Q1o′ a bond Me a bond NH O a bond T3a OH
    4360 CMe NMe Q1o′ a bond Me a bond NH O a bond T3b OH
    4361 CMe NMe Q1o′ a bond Me a bond NH O a bond T3c OH
    4362 CMe NMe Q1o′ a bond Me a bond NH O a bond T3d OH
    4363 CMe NMe Q1o′ a bond Me a bond NH O a bond T3e OH
    4364 CMe NMe Q1o′ a bond Me a bond NH O a bond T3f OH
    4365 CMe NMe Q1o′ a bond Me a bond NH O a bond T3g OH
    4366 CMe NMe Q1o′ a bond Me a bond NH O a bond T3h OH
    4367 CMe NMe Q1o′ a bond Me a bond NH O a bond T3i OH
    4368 CMe NMe Q1o′ a bond Me a bond NH O a bond T3j OH
    4369 CMe NMe Q1o′ a bond H a bond NH S NH Q3a OH
    4370 CMe NMe Q1o′ a bond H a bond NH S NH Q3e OH
    4371 CMe NMe Q1o′ a bond H a bond NH S NH T3a OH
    4372 CMe NMe Q1o′ a bond H a bond NH S NH T3b OH
    4373 CMe NMe Q1o′ a bond H a bond NH S NH T3c OH
    4374 CMe NMe Q1o′ a bond H a bond NH S NH T3d OH
    4375 CMe NMe Q1o′ a bond H a bond NH S NH T3e OH
    4376 CMe NMe Q1o′ a bond H a bond NH S NH T3f OH
    4377 CMe NMe Q1o′ a bond H a bond NH S NH T3g OH
    4378 CMe NMe Q1o′ a bond H a bond NH S NH T3h OH
    4379 CMe NMe Q1o′ a bond H a bond NH S NH T3i OH
    4380 CMe NMe Q1o′ a bond H a bond NH S NH T3j OH
    4381 CMe NMe Q1o′ a bond H a bond NH S a bond Q3a OH
    4382 CMe NMe Q1o′ a bond H a bond NH S a bond Q3e OH
    4383 CMe NMe Q1o′ a bond H a bond NH S a bond T3a OH
    4384 CMe NMe Q1o′ a bond H a bond NH S a bond T3b OH
    4385 CMe NMe Q1o′ a bond H a bond NH S a bond T3c OH
    4386 CMe NMe Q1o′ a bond H a bond NH S a bond T3d OH
    4387 CMe NMe Q1o′ a bond H a bond NH S a bond T3e OH
    4388 CMe NMe Q1o′ a bond H a bond NH S a bond T3f OH
    4389 CMe NMe Q1o′ a bond H a bond NH S a bond T3g OH
    4390 CMe NMe Q1o′ a bond H a bond NH S a bond T3h OH
    4391 CMe NMe Q1o′ a bond H a bond NH S a bond T3i OH
    4392 CMe NMe Q1o′ a bond H a bond NH S a bond T3j OH
    4393 CMe NMe Q1o′ a bond H a bond NH O NH Q3a OH
    4394 CMe NMe Q1o′ a bond H a bond NH O NH Q3e OH
    4395 CMe NMe Q1o′ a bond H a bond NH O NH T3a OH
    4396 CMe NMe Q1o′ a bond H a bond NH O NH T3b OH
    4397 CMe NMe Q1o′ a bond H a bond NH O NH T3c OH
    4398 CMe NMe Q1o′ a bond H a bond NH O NH T3d OH
    4399 CMe NMe Q1o′ a bond H a bond NH O NH T3e OH
    4400 CMe NMe Q1o′ a bond H a bond NH O NH T3f OH
    4401 CMe NMe Q1o′ a bond H a bond NH O NH T3g OH
    4402 CMe NMe Q1o′ a bond H a bond NH O NH T3h OH
    4403 CMe NMe Q1o′ a bond H a bond NH O NH T3i OH
    4404 CMe NMe Q1o′ a bond H a bond NH O NH T3j OH
    4405 CMe NMe Q1o′ a bond H a bond NH O a bond Q3a OH
    4406 CMe NMe Q1o′ a bond H a bond NH O a bond Q3e OH
    4407 CMe NMe Q1o′ a bond H a bond NH O a bond T3a OH
    4408 CMe NMe Q1o′ a bond H a bond NH O a bond T3b OH
    4409 CMe NMe Q1o′ a bond H a bond NH O a bond T3c OH
    4410 CMe NMe Q1o′ a bond H a bond NH O a bond T3d OH
    4411 CMe NMe Q1o′ a bond H a bond NH O a bond T3e OH
    4412 CMe NMe Q1o′ a bond H a bond NH O a bond T3f OH
    4413 CMe NMe Q1o′ a bond H a bond NH O a bond T3g OH
    4414 CMe NMe Q1o′ a bond H a bond NH O a bond T3h OH
    4415 CMe NMe Q1o′ a bond H a bond NH O a bond T3i OH
    4416 CMe NMe Q1o′ a bond H a bond NH O a bond T3j OH
    4417 CMe S Q1o′ a bond Me a bond NH S NH Q3a OH
    4418 CMe S Q1o′ a bond Me a bond NH S NH Q3e OH
    4419 CMe S Q1o′ a bond Me a bond NH S NH T3a OH
    4420 CMe S Q1o′ a bond Me a bond NH S NH T3b OH
    4421 CMe S Q1o′ a bond Me a bond NH S NH T3c OH
    4422 CMe S Q1o′ a bond Me a bond NH S NH T3d OH
    4423 CMe S Q1o′ a bond Me a bond NH S NH T3e OH
    4424 CMe S Q1o′ a bond Me a bond NH S NH T3f OH
    4425 CMe S Q1o′ a bond Me a bond NH S NH T3g OH
    4426 CMe S Q1o′ a bond Me a bond NH S NH T3h OH
    4427 CMe S Q1o′ a bond Me a bond NH S NH T3i OH
    4428 CMe S Q1o′ a bond Me a bond NH S NH T3j OH
    4429 CMe S Q1o′ a bond Me a bond NH S a bond Q3a OH
    4430 CMe S Q1o′ a bond Me a bond NH S a bond Q3e OH
    4431 CMe S Q1o′ a bond Me a bond NH S a bond T3a OH
    4432 CMe S Q1o′ a bond Me a bond NH S a bond T3b OH
    4433 CMe S Q1o′ a bond Me a bond NH S a bond T3c OH
    4434 CMe S Q1o′ a bond Me a bond NH S a bond T3d OH
    4435 CMe S Q1o′ a bond Me a bond NH S a bond T3e OH
    4436 CMe S Q1o′ a bond Me a bond NH S a bond T3f OH
    4437 CMe S Q1o′ a bond Me a bond NH S a bond T3g OH
    4438 CMe S Q1o′ a bond Me a bond NH S a bond T3h OH
    4439 CMe S Q1o′ a bond Me a bond NH S a bond T3i OH
    4440 CMe S Q1o′ a bond Me a bond NH S a bond T3j OH
    4441 CMe S Q1o′ a bond Me a bond NH O NH Q3a OH
    4442 CMe S Q1o′ a bond Me a bond NH O NH Q3e OH
    4443 CMe S Q1o′ a bond Me a bond NH O NH T3a OH
    4444 CMe S Q1o′ a bond Me a bond NH O NH T3b OH
    4445 CMe S Q1o′ a bond Me a bond NH O NH T3c OH
    4446 CMe S Q1o′ a bond Me a bond NH O NH T3d OH
    4447 CMe S Q1o′ a bond Me a bond NH O NH T3e OH
    4448 CMe S Q1o′ a bond Me a bond NH O NH T3f OH
    4449 CMe S Q1o′ a bond Me a bond NH O NH T3g OH
    4450 CMe S Q1o′ a bond Me a bond NH O NH T3h OH
    4451 CMe S Q1o′ a bond Me a bond NH O NH T3i OH
    4452 CMe S Q1o′ a bond Me a bond NH O NH T3j OH
    4453 CMe S Q1o′ a bond Me a bond NH O a bond Q3a OH
    4454 CMe S Q1o′ a bond Me a bond NH O a bond Q3e OH
    4455 CMe S Q1o′ a bond Me a bond NH O a bond T3a OH
    4456 CMe S Q1o′ a bond Me a bond NH O a bond T3b OH
    4457 CMe S Q1o′ a bond Me a bond NH O a bond T3c OH
    4458 CMe S Q1o′ a bond Me a bond NH O a bond T3d OH
    4459 CMe S Q1o′ a bond Me a bond NH O a bond T3e OH
    4460 CMe S Q1o′ a bond Me a bond NH O a bond T3f OH
    4461 CMe S Q1o′ a bond Me a bond NH O a bond T3g OH
    4462 CMe S Q1o′ a bond Me a bond NH O a bond T3h OH
    4463 CMe S Q1o′ a bond Me a bond NH O a bond T3i OH
    4464 CMe S Q1o′ a bond Me a bond NH O a bond T3j OH
    4465 CMe S Q1o′ a bond H a bond NH S NH Q3a OH
    4466 CMe S Q1o′ a bond H a bond NH S NH Q3e OH
    4467 CMe S Q1o′ a bond H a bond NH S NH T3a OH
    4468 CMe S Q1o′ a bond H a bond NH S NH T3b OH
    4469 CMe S Q1o′ a bond H a bond NH S NH T3c OH
    4470 CMe S Q1o′ a bond H a bond NH S NH T3d OH
    4471 CMe S Q1o′ a bond H a bond NH S NH T3e OH
    4472 CMe S Q1o′ a bond H a bond NH S NH T3f OH
    4473 CMe S Q1o′ a bond H a bond NH S NH T3g OH
    4474 CMe S Q1o′ a bond H a bond NH S NH T3h OH
    4475 CMe S Q1o′ a bond H a bond NH S NH T3i OH
    4476 CMe S Q1o′ a bond H a bond NH S NH T3j OH
    4477 CMe S Q1o′ a bond H a bond NH S a bond Q3a OH
    4478 CMe S Q1o′ a bond H a bond NH S a bond Q3e OH
    4479 CMe S Q1o′ a bond H a bond NH S a bond T3a OH
    4480 CMe S Q1o′ a bond H a bond NH S a bond T3b OH
    4481 CMe S Q1o′ a bond H a bond NH S a bond T3c OH
    4482 CMe S Q1o′ a bond H a bond NH S a bond T3d OH
    4483 CMe S Q1o′ a bond H a bond NH S a bond T3e OH
    4484 CMe S Q1o′ a bond H a bond NH S a bond T3f OH
    4485 CMe S Q1o′ a bond H a bond NH S a bond T3g OH
    4486 CMe S Q1o′ a bond H a bond NH S a bond T3h OH
    4487 CMe S Q1o′ a bond H a bond NH S a bond T3i OH
    4488 CMe S Q1o′ a bond H a bond NH S a bond T3j OH
    4489 CMe S Q1o′ a bond H a bond NH O NH Q3a OH
    4490 CMe S Q1o′ a bond H a bond NH O NH Q3e OH
    4491 CMe S Q1o′ a bond H a bond NH O NH T3a OH
    4492 CMe S Q1o′ a bond H a bond NH O NH T3b OH
    4493 CMe S Q1o′ a bond H a bond NH O NH T3c OH
    4494 CMe S Q1o′ a bond H a bond NH O NH T3d OH
    4495 CMe S Q1o′ a bond H a bond NH O NH T3e OH
    4496 CMe S Q1o′ a bond H a bond NH O NH T3f OH
    4497 CMe S Q1o′ a bond H a bond NH O NH T3g OH
    4498 CMe S Q1o′ a bond H a bond NH O NH T3h OH
    4499 CMe S Q1o′ a bond H a bond NH O NH T3i OH
    4500 CMe S Q1o′ a bond H a bond NH O NH T3j OH
    4501 CMe S Q1o′ a bond H a bond NH O a bond Q3a OH
    4502 CMe S Q1o′ a bond H a bond NH O a bond Q3e OH
    4503 CMe S Q1o′ a bond H a bond NH O a bond T3a OH
    4504 CMe S Q1o′ a bond H a bond NH O a bond T3b OH
    4505 CMe S Q1o′ a bond H a bond NH O a bond T3c OH
    4506 CMe S Q1o′ a bond H a bond NH O a bond T3d OH
    4507 CMe S Q1o′ a bond H a bond NH O a bond T3e OH
    4508 CMe S Q1o′ a bond H a bond NH O a bond T3f OH
    4509 CMe S Q1o′ a bond H a bond NH O a bond T3g OH
    4510 CMe S Q1o′ a bond H a bond NH O a bond T3h OH
    4511 CMe S Q1o′ a bond H a bond NH O a bond T3i OH
    4512 CMe S Q1o′ a bond H a bond NH O a bond T3j OH
    4513 CMe O Q1o′ a bond Me a bond NH S NH Q3a OH
    4514 CMe O Q1o′ a bond Me a bond NH S NH Q3e OH
    4515 CMe O Q1o′ a bond Me a bond NH S NH T3a OH
    4516 CMe O Q1o′ a bond Me a bond NH S NH T3b OH
    4517 CMe O Q1o′ a bond Me a bond NH S NH T3c OH
    4518 CMe O Q1o′ a bond Me a bond NH S NH T3d OH
    4519 CMe O Q1o′ a bond Me a bond NH S NH T3e OH
    4520 CMe O Q1o′ a bond Me a bond NH S NH T3f OH
    4521 CMe O Q1o′ a bond Me a bond NH S NH T3g OH
    4522 CMe O Q1o′ a bond Me a bond NH S NH T3h OH
    4523 CMe O Q1o′ a bond Me a bond NH S NH T3i OH
    4524 CMe O Q1o′ a bond Me a bond NH S NH T3j OH
    4525 CMe O Q1o′ a bond Me a bond NH S a bond Q3a OH
    4526 CMe O Q1o′ a bond Me a bond NH S a bond Q3e OH
    4527 CMe O Q1o′ a bond Me a bond NH S a bond T3a OH
    4528 CMe O Q1o′ a bond Me a bond NH S a bond T3b OH
    4529 CMe O Q1o′ a bond Me a bond NH S a bond T3c OH
    4530 CMe O Q1o′ a bond Me a bond NH S a bond T3d OH
    4531 CMe O Q1o′ a bond Me a bond NH S a bond T3e OH
    4532 CMe O Q1o′ a bond Me a bond NH S a bond T3f OH
    4533 CMe O Q1o′ a bond Me a bond NH S a bond T3g OH
    4534 CMe O Q1o′ a bond Me a bond NH S a bond T3h OH
    4535 CMe O Q1o′ a bond Me a bond NH S a bond T3i OH
    4536 CMe O Q1o′ a bond Me a bond NH S a bond T3j OH
    4537 CMe O Q1o′ a bond Me a bond NH O NH Q3a OH
    4538 CMe O Q1o′ a bond Me a bond NH O NH Q3e OH
    4539 CMe O Q1o′ a bond Me a bond NH O NH T3a OH
    4540 CMe O Q1o′ a bond Me a bond NH O NH T3b OH
    4541 CMe O Q1o′ a bond Me a bond NH O NH T3c OH
    4542 CMe O Q1o′ a bond Me a bond NH O NH T3d OH
    4543 CMe O Q1o′ a bond Me a bond NH O NH T3e OH
    4544 CMe O Q1o′ a bond Me a bond NH O NH T3f OH
    4545 CMe O Q1o′ a bond Me a bond NH O NH T3g OH
    4546 CMe O Q1o′ a bond Me a bond NH O NH T3h OH
    4547 CMe O Q1o′ a bond Me a bond NH O NH T3i OH
    4548 CMe O Q1o′ a bond Me a bond NH O NH T3j OH
    4549 CMe O Q1o′ a bond Me a bond NH O a bond Q3a OH
    4550 CMe O Q1o′ a bond Me a bond NH O a bond Q3e OH
    4551 CMe O Q1o′ a bond Me a bond NH O a bond T3a OH
    4552 CMe O Q1o′ a bond Me a bond NH O a bond T3b OH
    4553 CMe O Q1o′ a bond Me a bond NH O a bond T3c OH
    4554 CMe O Q1o′ a bond Me a bond NH O a bond T3d OH
    4555 CMe O Q1o′ a bond Me a bond NH O a bond T3e OH
    4556 CMe O Q1o′ a bond Me a bond NH O a bond T3f OH
    4557 CMe O Q1o′ a bond Me a bond NH O a bond T3g OH
    4558 CMe O Q1o′ a bond Me a bond NH O a bond T3h OH
    4559 CMe O Q1o′ a bond Me a bond NH O a bond T3i OH
    4560 CMe O Q1o′ a bond Me a bond NH O a bond T3j OH
    4561 CMe O Q1o′ a bond H a bond NH S NH Q3a OH
    4562 CMe O Q1o′ a bond H a bond NH S NH Q3e OH
    4563 CMe O Q1o′ a bond H a bond NH S NH T3a OH
    4564 CMe O Q1o′ a bond H a bond NH S NH T3b OH
    4565 CMe O Q1o′ a bond H a bond NH S NH T3c OH
    4566 CMe O Q1o′ a bond H a bond NH S NH T3d OH
    4567 CMe O Q1o′ a bond H a bond NH S NH T3e OH
    4568 CMe O Q1o′ a bond H a bond NH S NH T3f OH
    4569 CMe O Q1o′ a bond H a bond NH S NH T3g OH
    4570 CMe O Q1o′ a bond H a bond NH S NH T3h OH
    4571 CMe O Q1o′ a bond H a bond NH S NH T3i OH
    4572 CMe O Q1o′ a bond H a bond NH S NH T3j OH
    4573 CMe O Q1o′ a bond H a bond NH S a bond Q3a OH
    4574 CMe O Q1o′ a bond H a bond NH S a bond Q3e OH
    4575 CMe O Q1o′ a bond H a bond NH S a bond T3a OH
    4576 CMe O Q1o′ a bond H a bond NH S a bond T3b OH
    4577 CMe O Q1o′ a bond H a bond NH S a bond T3c OH
    4578 CMe O Q1o′ a bond H a bond NH S a bond T3d OH
    4579 CMe O Q1o′ a bond H a bond NH S a bond T3e OH
    4580 CMe O Q1o′ a bond H a bond NH S a bond T3f OH
    4581 CMe O Q1o′ a bond H a bond NH S a bond T3g OH
    4582 CMe O Q1o′ a bond H a bond NH S a bond T3h OH
    4583 CMe O Q1o′ a bond H a bond NH S a bond T3i OH
    4584 CMe O Q1o′ a bond H a bond NH S a bond T3j OH
    4585 CMe O Q1o′ a bond H a bond NH O NH Q3a OH
    4586 CMe O Q1o′ a bond H a bond NH O NH Q3e OH
    4587 CMe O Q1o′ a bond H a bond NH O NH T3a OH
    4588 CMe O Q1o′ a bond H a bond NH O NH T3b OH
    4589 CMe O Q1o′ a bond H a bond NH O NH T3c OH
    4590 CMe O Q1o′ a bond H a bond NH O NH T3d OH
    4591 CMe O Q1o′ a bond H a bond NH O NH T3e OH
    4592 CMe O Q1o′ a bond H a bond NH O NH T3f OH
    4593 CMe O Q1o′ a bond H a bond NH O NH T3g OH
    4594 CMe O Q1o′ a bond H a bond NH O NH T3h OH
    4595 CMe O Q1o′ a bond H a bond NH O NH T3i OH
    4596 CMe O Q1o′ a bond H a bond NH O NH T3j OH
    4597 CMe O Q1o′ a bond H a bond NH O a bond Q3a OH
    4598 CMe O Q1o′ a bond H a bond NH O a bond Q3e OH
    4599 CMe O Q1o′ a bond H a bond NH O a bond T3a OH
    4600 CMe O Q1o′ a bond H a bond NH O a bond T3b OH
    4601 CMe O Q1o′ a bond H a bond NH O a bond T3c OH
    4602 CMe O Q1o′ a bond H a bond NH O a bond T3d OH
    4603 CMe O Q1o′ a bond H a bond NH O a bond T3e OH
    4604 CMe O Q1o′ a bond H a bond NH O a bond T3f OH
    4605 CMe O Q1o′ a bond H a bond NH O a bond T3g OH
    4606 CMe O Q1o′ a bond H a bond NH O a bond T3h OH
    4607 CMe O Q1o′ a bond H a bond NH O a bond T3i OH
    4608 CMe O Q1o′ a bond H a bond NH O a bond T3j OH
  • 74) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 74), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00013
    Figure US20140051857A1-20140220-C00014
  • 75) The compounds in Table 6 wherein A, B, R1, L1, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (providedthat in the case of 75), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b; T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00015
    Figure US20140051857A1-20140220-C00016
  • 76) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table Z, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 76), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00017
    Figure US20140051857A1-20140220-C00018
  • 77) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 77), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00019
    Figure US20140051857A1-20140220-C00020
  • 78) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any oof the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 78), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00021
    Figure US20140051857A1-20140220-C00022
  • 79) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 79), Q1a, Q1b, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00023
    Figure US20140051857A1-20140220-C00024
  • 80) The compounds in Table 6 wherein A, B, R1, L1, R2 L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 80), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00025
    Figure US20140051857A1-20140220-C00026
  • 81) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 81), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00027
    Figure US20140051857A1-20140220-C00028
  • 82) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 82), Q1a, Q1b, Q1c, Q1i, Q1j, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T1g, T3h, Q3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00029
    Figure US20140051857A1-20140220-C00030
  • 83) The compounds in Table 6 wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are any of the following combinations in Table 6, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof (provided that in the case of 83), Q1a, Q1b, Q1c, Q1o′, Q3a, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in Table 6 denote the following substituents).
  • Figure US20140051857A1-20140220-C00031
    Figure US20140051857A1-20140220-C00032
  • 84) The compound represented by any of 68) to 83) wherein X is converted to SH, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 85) The compound represented by any of 68) to 83) wherein X is converted to NH2, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 86) The compound represented by any of 68) to 83) wherein X is converted to OAc, tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof.
  • 87) The thrombopoietin receptor activators represented by any of 1) to 86).
  • 88) Preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective which contain the thrombopoietin receptor activators represented by 87) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.
  • 89) Platelet increasing agents containing the thrombopoietin receptor activators represented by 87) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof, as an active ingredient.
  • 90) Medicaments containing the compounds represented by any of 1) to 86) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of the compounds or solvates thereof, as an active ingredient.
  • In the present invention, the compounds of the present invention represented by the formula (1) may be present in the form of tautomers or geometrical isomers which undergo endocyclic or exocyclic isomerization, mixtures of tautomers or geometric isomers or mixtures of thereof. When the compounds of the present invention have an asymmetric center, whether or not resulting from an isomerization, the compounds of the present invention may be in the form of resolved optical isomers or in the form of mixtures containing them in certain ratios.
  • For example, furan compounds, thiophene compounds and pyrrole compounds of the present invention may be present in the form of tetronic acid (4-hydroxy-2(5H)-furanone) analogues, thiotetronic acid (4-hydroxy-2(5H)-thiophenone) analogues and tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogues as shown below by the formulae (2), (3) and (4), mixtures thereof or mixtures of isomers thereof.
  • Figure US20140051857A1-20140220-C00033
  • The compounds of the present invention represented by the formula (1) or pharmaceutically acceptable salts thereof may be in the form of arbitrary crystals or arbitrary hydrates, depending on the production conditions. The present invention covers these crystals, hydrates and mixtures. They may be in the form of solvates with organic solvents such as acetone, ethanol and tetrahydrofuran, and the present invention covers any of these forms.
  • The compounds of the present invention represented by the formula (1) may be converted to pharmaceutically acceptable salts or may be liberated from the resulting salts, if necessary. The pharmaceutically acceptable salts of the present invention may be, for example, salts with alkali metals (such as lithium, sodium and potassium), alkaline earth metals (such as magnesium and calcium), ammonium, organic bases and amino acids. They may be salts with inorganic acids (such as hydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid) and organic acids (such as acetic acid, citric acid, maleic acid, fumaric acid, benzenesulfonic acid and p-toluenesulfonic acid).
  • The compounds which serve as prodrugs are derivatives of the present invention having chemically or metabolically degradable groups which give pharmacologically active compounds of the present invention upon solvolysis or under physiological conditions in vivo. Methods for selecting or producing appropriate prodrugs are disclosed, for example, in Design of Prodrug (Elsevier, Amsterdam 1985). In the present invention, when the compound has a hydroxyl group, acyloxy derivatives obtained by reacting the compound with appropriate acyl halides or appropriate acid anhydrides may, for example, be mentioned as prodrugs. Acyloxys particularly preferred as prodrugs include —OCOC2H5, —OCO(t-Eu), —OCOC15H31, —OCO(m-CO2Na-Ph), —OCOCH2CH2CO2Na, —OCOCH(NH2)CH3, —OCOCH2N(CH3)2 and the like. When the compound of the present invention has an amino group, amide derivatives obtained by reacting the compound having an amino group with appropriate acid halides or appropriate mixed acid anhydrides may, for example, be mentioned as prodrugs. Amides particularly preferred as prodrugs include —NHCO(CH2)20OCH3, —NHCOCH(NH2)CH3 and the like. When the compound of the present invention has a carboxyl group, carboxylic acid esters with aliphatic alcohols or carboxylic acid esters obtained by the reaction with an alcoholic free hydroxyl group of 1,2- or 1,3-digylcerides may, for example, be mentioned as prodrugs. Particularly preferred prodrugs are methyl esters and ethyl esters.
  • The preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective or platelet increasing agents which contain the thrombopoietin receptor activators of the present invention, tautomers, prodrugs or pharmaceutically acceptable salts of the activators or solvates thereof as an active ingredient may usually be administered as oral medicines such as tablets, capsules, powder, granules, pills and syrup, as rectal medicines, percutaneous medicines or injections. The agents of the present invention may be administered as a single therapeutic agent or as a mixture with other therapeutic agents. Though they may be administered as they are, they are usually administered in the form of medical compositions. These pharmaceutical preparations can be obtained by adding pharmacologically and pharmaceutically acceptable additives by conventional methods. Namely, for oral medicines, ordinary excipients, lubricants, binders, disintegrants, humectants, plasticizers and coating agents may be used. Oral liquid preparations may be in the form of aqueous or oily suspensions, solutions, emulsions, syrups or elixirs or may be supplied as dry syrups to be mixed with water or other appropriate solvents before use. Such liquid preparations may contain ordinary additives such as suspending agents, perfumes, diluents and emulsifiers. In the case of rectal administration, they may be administered as suppositories. Suppositories may use an appropriate substance such as cacao butter, laurin tallow, Macrogol, glycerogelatin, Witepsol, sodium stearate and mixtures thereof as the base and may, if necessary, contain an emulsifier, a suspending agent, a preservative and the like. For injections, pharmaceutical ingredients such as distilled water for injection, physiological saline, 5% glucose solution, propylene glycol and other solvents or solubilizing agents, a pH regulator, an isotonizing agent and a stabilizer may be used to form aqueous dosage forms or dosage forms which need dissolution before use.
  • The dose of the agents of the present invention for administration to human is usually about from 0.1 to 1000 mg/human/day in the case of oral drugs or rectal administration and about from 0.05 mg to 500 mg/human/day in the case of injections, though it depends on the age and conditions of the patient. The above-mentioned ranges are mere examples, and the dose should be determined from the conditions of the patient.
  • The present invention is used when the use of compounds which have thrombopoietin receptor affinity and act as thrombopoietin receptor agonists are expected to improve pathological conditions. For example, hematological disorders accompanied by abnormal platelet count may be mentioned. Specifically, it is effective for therapy or prevention of human and mammalian diseases caused by abnormal megakaryopoiesis, especially those accompanied by thrombocytopenia. Examples of such diseases include thrombocytopenia accompanying chemotherapy or radiotherapy of cancer, thrombocytopenia accompanying antiviral therapy for diseases such as hepatitis C, thrombocytopenia caused by bone marrow transplantation, surgery and serious infections, or gastrointestinal bleeding, but such diseases are not restricted to those mentioned. Typical thrombocytopenias such as aplastic anemia, idiopathic thrombocytopenic purpura, myelodysplastic syndrome, hepatic disease, HIV infection and thrombopoietin deficiency are also targets of the agents of the present invention. The present invention may be used as a peripheral stem cell mobilizer, a megakaryoblastic or megakaryocytic leukemia cell differentiation inducer and a platelet increasing agent for platelet donors. In addition, potential applications include therapeutic angiogenesis based on differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, prevention and therapy of arteriosclerosis, myocardial infarction, unstable angina, peripheral artery occlusive disease, but there is no restriction.
  • The compounds represented by the formula (1) are prepared by the process represented by the formula (5) illustrated below.
  • Figure US20140051857A1-20140220-C00034
  • The reaction of the compound (I) with a —NH2 compound (II) in a solvent, if necessary in the presence of a catalyst, under heating with stirring gives a desired compound or its precursor. The precursor may be, if necessary, hydrolyzed, deprotected, reduced or oxidized to a desired compound. The compounds of the present invention usually can be purified by column chromatography, thin layer chromatography, high performance liquid chromatography (HPLC) or high performance liquid chromatography-mass spectrometry (LC-MS) and, if necessary, they may be obtained with high purity by recrystallization or washing with solvents.
  • For the syntheses of the intermediates (I), syntheses of the following heterocyclic compounds may be is referred to.
    • 1) Pyrazole (the formula (6))
    • J. Chem. Soc. Perkin. Transl, p. 81, (1985.)
    • 2) Isothiazole (the formula (7))
    • Liebigs. Annalen. der. Chemie., 10, 1534-1546 (1979)
    • 3) Isoxazole (the formula (8))
    • Synthesis, 10, 664-665 (1975)
    • 4) Thiophene (the formula (9))
    • JP-A-48-026755
    • 5) Furan (the formula (10))
    • J. Org. Chem., 21, 1492-1509 (1956)
    • 6) Pyrrole (the formula (11))
    • J. Heterocyclic Chem., 30, 1253 (1993) and Tetrahedron, 50(26), 7849-56 (1994)
    • 7.) Tetronic acid (4-hydroxy-2(5H)-furanone) analogue (the formula (12))
    • Synthesis, 7, 564-566 (1988) and Yakugaku Zasshi, 96(4), 536-543 (1976).
    • 8) Tetraminic acid (4-hydroxy-3-pyrrolin-2-one) analogue (the formula (13))
    • Synthesis, 2, 190-192 (1987) and Agric. Biol. Chem., 43(8), 1641-1646 (1979)
  • Figure US20140051857A1-20140220-C00035
    Figure US20140051857A1-20140220-C00036
    Figure US20140051857A1-20140220-C00037
    Figure US20140051857A1-20140220-C00038
  • For synthesis of the —NH2 compounds (II), for example, when L3=NH, the following may be referred to.
    • 1) L4=a bond, Y═O
    • Synthetic Commun., 28(7), 1223-1231 (1998), J. Chem. Soc., 1225 (1948) and J. Chem. Soc., 2831 (1952)
    • 2) L4=NH, Y═O
    • J. Am. Chem. Soc., 46, 2813 (1924) and J. Chem. Soc., 2654 (1952)
    • 3) L4=NH, Y═S
    • Can. J. Chem., 35, 834 (1957)
    • 4) L4=CH2, Y═O
    • J. Org. Chem., 30, 2487 (1965)
    • 5) L4=0, Y=0
    • Bull. Soc. Chim. Belg., 68, 409, (1959)
    EXAMPLES
  • Now, the present invention will be described in further detail with reference to Reference Synthetic Examples, Synthetic Examples, Assay Examples and Formulation Examples. However, it should be understood that the present invention is by no means restricted by these specific Examples.
  • The 1H-NMR analysis was carried out at 300 MHz.
  • In the REFERENCE SYNTHETIC EXAMPLE 59-75 and the SYNTHETIC EXAMPLE 124-240, LC/MS was measured on the following conditions.
  • LC/MS condition 1
    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 30/70)
    LC/MS condition 2
    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 60/40)
    LC/MS condition 3
    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 85/15)
    LC/MS condition 4
    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 30/70)
    LC/MS condition 5
    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 60/40)
    LC/MS condition 6
    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (10/90 to 85/15)
    LC/MS condition 7
    column: Waters Xterra MSC18(5 μm, 4.6×50 mm)
    elute: MeCN/0.1% aq.HCOOH (20/80 to 100/0)
    LC/MS condition 8
    column: Waters Xterra MSC18(3.5 μm, 2.1×20 mm)
    elute: MeCN/0.2% aq.HCOOH (20/80 to 90/10)
    LC/MS condition 9
    column: Waters SunFire C18(3.5 μm, 4.6×30 mm)
    elute: MeCN/0.1% aq.HCOOH (20/80 to 100/0)
    • Reference Synthetic Example 1 Synthesis of 2-oxopropanal methylhydrazone
  • A mixed solution of methylhydrazine (8.34 mL, 158.22 mmol) in acetic acid (15 mL) and water (60 mL) was added to 10% methylglyoxal aqueous solution (92.5 mL, 151.21 mmol), and the mixture was stirred at room temperature for about 24 hours. The reaction solution was extracted with chloroform three times, and the extract was dried, filtered and concentrated. Purification of the resulting black solution by vacuum distillation gave the desired product as a yellow solid (5.357 g, yield 35%).
  • 1H-NMR (ppm in CDCl3) δ 6.86 (s, 1H), 6.59 (br.s, 1H), 2.98 (d, J=4.2 Hz, 3H), 2.30 (s, 3H)
  • LC-MS (ESI) 100 (M+)
    • Reference Synthetic Example 2 Synthesis of 2-oxopropanal ethylhydrazone
  • Ethylhydrazine (8.46 mmol, 556 mg) was dissolved in methanol (4 mL), and the reactor was cooled to 0° C. Methylglyoxal (40% in H2O, 9.3 mmol, 1.42 mL) was added, and the mixture was stirred for 15 minutes at the same temperature and then for 2.5 hours at room temperature. After addition of water, it was extracted with chloroform three times. The resulting organic layer was dried over anhydrous magnesium sulfate and filtered, and the solvent was evaporated with an evaporator. The residue was dried by means of a vacuum pump to give the desired product as an orange liquid (0.955 g (crude), yield 99%).
  • 1H-NMR (ppm in CDCl3)
  • δ 9.29 (s, 1H), 6.32 (br.s, 1H), 3.58 (q, J=7.1 Hz, 1H), 3.57 (q, J=7.1 Hz, 1H), 1.79 (s, 3H), 1.29 (t, J=7.1 Hz, 3H)
    • Reference Synthetic Example 3 Synthesis of (3,4-dichlorophenyl)(oxo)acetaldehyde
  • 3,4-dichloroacetophenone (5.39 mmol, 1.02 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (1.83 mL) was gradually added at room temperature. The mixture was stirred overnight at 60° C., and then the reactor was cooled to room temperature. The reaction solution was poured into water (50 mL) at 0° C. and stirred for about 1 hour. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a pale yellow solid (0.780 g, yield 71%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 8.26 (d, J=2.0 Hz, 1H), 8.01 (dd, J=2.0, 8.6 Hz, 1H), 7.82 (d, J=8.6 Hz, 1H), 7.01 (d, J=6.6 Hz, 2H, H2O), 5.61 (br.s, 1H)
  • MS (EI) 173 (M+−CHO)
    • Reference Synthetic Example 4 Synthesis of (4-t-butylphenyl)(oxo)acetaldehyde
  • 4-t-Butylacetophenone (100 mmol, 18.74 mL) was dissolved in dimethyl sulfoxide (104 mL), then the reactor was cooled to 0° C., and 48% hydrobromic acid (34 mL) was gradually added. After 18 hours of stirring at 70° C., the reaction solution was poured into water (400 mL) and stirred for 24 hours. The precipitated yellow solid was recovered by filtration, washed with n-hexane several times and dried by means of a vacuum pump to give the desired product as a pale yellow solid (13.89 g, yield 73%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 8.01 (ABq, J=8.4 Hz, 2H), 7.51 (ABq, J=8.4 Hz, 2H), 6.01 (s, 1H), 1.30 (s, 9H)
  • LC-MS (ESI) 190 (M+)
    • Reference Synthetic Example 5 Synthesis of (3,4-dimethylphenyl)(oxo)acetaldehyde
  • 3,4-dimethylacetophenone (13.52 mmol, 2.0 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After 16 hours of stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water and stirred for about 16 hours. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a white solid (1.234g, yield 57%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.83-7.80 (multi, 2H), 7.33 (br.s, 2H, H2O), 7.26 (d, J=7.5 Hz, 1H), 5.96 (br.s, 1H), 2.28 (s, 3H), 2.22 (s, 3H)
    • Reference Synthetic Example 6 Synthesis of (4-n-pentylphenyl)(oxo)acetaldehyde
  • 4-n-Pentylacetophenone (10.66 mmol, 2.028 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After 9.5 hours of stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water and stirred for about 16 hours. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a pale yellow solid (2.1784 g (crude), 100%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.99 (ABq, J=8.3 Hz, 2H), 7.33 (ABq, J=8.3 Hz, 2H), 6.67 (br.s, 2H, H2O), 5.67 (br.s, 1H), 2.69-2.61 (multi, 2H), 1.66-1.50 (multi, 2H), 1.36-1.20 (multi, 4H), 0.88-0.83 (multi, 3H).
    • Reference Synthetic Example 7 Synthesis of (4-trifluoromethylphenyl)(oxo)acetaldehyde
  • 4-Trifluoromethylacetophenone (11.14 mmol, 2.096 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After 9.5 hours of stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water and stirred for about 16 hours. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (1.3116 g, yield 59%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 8.27 (ABq, J=8.3 Hz, 2H), 7.90 (ABq, J=8.3 Hz, 2H), 6.97 (br.s, 2H, H2O), 5.68 (br.s, 1H)
    • Reference Synthetic Example 8 Synthesis of oxo[3-(trifluoromethyl)phenyl]acetaldehyde
  • 3-Trifluoromethylacetophenone (11.80 mmol, 2.22 g) was dissolved in dimethyl, sulfoxide (13 mL), and 48% hydrobromic acid (5.4 mL) was gradually added at room temperature. After overnight stirring at 70° C., the reactor was cooled to room temperature. After addition of water, the reaction solution was extracted with chloroform, and the extract was dried and filtered, and the solvent was evaporated to give the desired product as a yellow liquid (3.04 g (crude), yield 128%).
    • Reference Synthetic Example 9 Synthesis of (3-bromo-4-fluorophenyl)(oxo)acetaldehyde
  • From 3-bromo-4-fluoroacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow liquid (crude, yield 114%).
    • Reference Synthetic Example 10 Synthesis of (3,5-dimethylphenyl)(oxo)acetaldehyde
  • From 3,5-dimethylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow solid (crude, yield 104%).
    • Reference Synthetic Example 11 Synthesis of (4-ethylphenyl)(oxo)acetaldehyde
  • 4-Ethylacetophenone (26.72 mmol, 4 mL) was dissolved in dimethyl sulfoxide (27 mL), and 48% hydrobromic acid (11 mL) was gradually added at room temperature. After overnight stirring at 70° C., the reactor was cooled to room temperature. The reaction solution was poured into water (50 mL) and stirred for about 1 hour. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a white solid (2.44 g, yield 56%).
    • Reference Synthetic Example 12 Synthesis of (4-isopropylphenyl)(oxo)acetaldehyde
  • From 4-isopropylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow solid (crude, yield 103%).
    • Reference Synthetic Example 13 Synthesis of oxo(4-n-propylphenyl)acetaldehyde
  • From 4-n-propylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 11 as a yellow liquid (crude, yield 92%).
    • Reference Synthetic Example 14 Synthesis of (4-n-hexylphenyl)(oxo)acetaldehyde
  • From 4-n-hexylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 11 as a yellow solid (crude, yield 131%).
    • Reference Synthetic Example 15 Synthesis of (4-isobutylphenyl)(oxo)acetaldehyde
  • From 4-isobutylacetophenone, the desired product was obtained in the same manner as in Reference Synthetic Example 8 as a yellow liquid (crude, yield 1080).
    • Reference Synthetic Example 16 Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
  • 60% Sodium hydride (28 mg, 0.69 mmol) was added to a solution of 2-(4-t-butylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene (0.20 g, 0.66 mmol) obtained in accordance with JP-A-48-26755 in dimethylformamide (1.0 mL) at room temperature, and the reaction solution was stirred at 60° C. for 15 minutes. After the reaction solution was cooled to room temperature, chloromethyl methyl ether (0.055 mL, 0.73 mmol) was added dropwise, and the reaction solution was stirred at room temperature for another 5 hours. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate. The organic layer was concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a colorless oil (212 mg, yield 91%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.34 (s, 9H), 1.38 (t, J=7.2 Hz, 3H), 3.23 (s, 3H), 4.34 (q, J=7.2. Hz, 2H), 5.00 (s, 2H), 7.41-7.44 (m, 2H), 7.60-7.63 (m, 2H), 7.97 (s, 1H).
  • LC/MS (ES+) 371 (Na+ adduct).
    • Reference Synthetic Example 17 Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
  • From 2-(3,4-dichlorophenyl)-3-hydroxy-4-ethoxycarbonylthiophene (7.7 g, 24 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 16 as a colorless oil (5.4 g, yield 62%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.38 (t, J=7.2 Hz, 3H), 3.27 (s, 3H), 4.34 (q, J=7.2 Hz, 2H), 5.06 (s, 2H), 7.46-7.54 (m, 2H), 7.86 (d, J=1.9 Hz, 1H), 8.04 (s, 1H).
    • Reference Synthetic Example 18 Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
  • From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene (1.6 g, 5.2 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 16 as a brown oil (1.8 g, yield 95%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.39 (t, J=7.2 Hz, 3H), 3.21 (s, 3H), 4.35 (q, J=7.2 Hz, 2H), 5.05 (s, 2H), 7.67 (d, J=8.3 Hz, 2H), 7.83 (d, J=8.3 Hz, 2H), 8.07 (s, 1H).
    • Reference Synthetic Example 19 Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
  • To lithium aluminium hydride (27 mg, 0.72 mmol) in THF (0.86 mL), 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (0.21 g, 0.60 mmol) in THF (0.86 mL) was added dropwise under cooling with ice, and the reaction solution was stirred under cooling with ice for 1 hour. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a colorless oil (87 mg, yield 47%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.25 (s, 9H), 3.05 (bs, 1H), 3.40 (s, 3H), 4.46 (d, J=5.8 Hz, 2H), 4.81 (s, 2H), 7.02 (s, 1H), 7.30-7.34 (m, 2H), 7.47-7.50 (m, 2H).
  • LC/MS (ES+) 329 (Na+ adduct).
    • Reference Synthetic Example 20 Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
  • From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (5.0 g, 14 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 19 as a colorless oil (4.3 g, 98%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.51 (s, 3H), 4.56 (d, J. 5.8 Hz, 2H), 4.91 (s, 2H), 7.21 (s, 1H), 7.43-7.51 (m, 2H), 7.89 (s, 1H).
  • LC/MS (ES+) 340, 342 (Na+ adduct).
  • LC/MS (ES−) 363, 364, 365 (HCO2 − adduct).
    • Reference Synthetic Example 21 Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
  • From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (1.8 g, 4.9 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 19 as a yellow oil (1.4 g, yield 92).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.50 (s, 3H), 4.57 (s, 2H), 4.91 (s, 2H), 7.24 (s, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.78 (d, J=8.4 Hz, 2H).
  • LC/MS (ES+) 341 (Na+ adduct).
    • Reference Synthetic Example 22 Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene
  • Dimethyl sulfoxide (0.050 mL, 0.70 mmol) in dichloromethane (0.28 mL) was added to oxalyl chloride (0.049 mL, 0.56 mmol) in dichloromethane (2.8 mL) at −78° C., and after 10 minutes of stirring at −78° C., 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (87 mg, 0.28 mmol) in dichloromethane (0.93 mL) was added dropwise. After the addition, the reaction solution was stirred at −78° C. for 20 minutes and at −40 to −50° C. for 1 hour. Triethylamine (0.28 mL, 2.0 mmol) was added dropwise, and the reaction solution was stirred for another 20 minutes under cooling with ice. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with chloroform, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated to give the desired product as a brown oil (58 mg, yield 68%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.25 (s, 9H), 3.24 (s, 3H), 4.91 (s, 2H), 7.34-7.38 (m, 2H), 7.50-7.54 (m, 2H), 7.91 (s, 1H), 9.82 (s, 1H).
  • LC/MS (ES+) 305.
    • Reference Synthetic Example 23 Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene
  • From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (4.3 g, 14 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 22 as a colorless oil (5.2 g, yield 122%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.50 (s, 3H), 5.04 (s, 2H), 7.48-7.54 (m, 2H), 7.84 (d, J=1.7 Hz, 1H), 8.04 (s, 1H), 9.88 (s, 1H).
    • Reference Synthetic Example 24 Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene
  • 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (1.4 g, 4.3 mmol) in chloroform (22 ml) was stirred with manganese dioxide (3.7 g, 43 mmol) at room temperature for 20 hours and at 50° C. for 3 hours. The reaction solution was filtered, and the filtrate was concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a colorless oil (0.79 g, yield 57%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.29 (s, 3H), 5.03 (s, 2H), 7.68 (d, J=8.5 Hz, 2H), 7.82 (d, J=8.5 Hz, 2H), 8.08 (s, 1H), 9.91 (s, 1H).
  • LC/MS (ES+) 339 (Na+ adduct).
    • Reference Synthetic Example 25 Synthesis of 2-(4-t-butylphenyl)-3-hydroxy-4-formylthiophene
  • To 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.20 g, 0.66 mmol) in 1,4-dioxane (1.3 mL), 1 M hydrochloric acid (0.66 mL, 0.66 mmol) was added dropwise, and the reaction solution was stirred at 65° C. for 1 hour and at 80° C. for 1 hour. After addition of water, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a reddish brown oil (0.12 g, yield 68%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.38 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.70 (d, J=8.4 Hz, 2H), 7.88 (s, 1H), 9.24 (s, 1H), 9.85 (s, 1H).
    • Reference Synthetic Example 26 Synthesis of 2-(3,4-dichlorophenyl)-3-hydroxy-4-formylthiophene
  • From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene (1.7 g, 5.4 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a brown oil (1.2 g, yield 83%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.68 (s, 2H), 7.80 (s, 1H), 8.48 (s, 1H), 9.89 (s, 1H), 10.07 (s, 1H).
  • LC/MS (ES−) 271, 273.
    • Reference Synthetic Example 27 Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl) thiophene
  • 3.0 M Ethyl ether solution (2.0 mL, 6.0 mmol) of methylmagnesium bromide was added dropwise to 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.77 g, 2.5 mmol) in THF (2.5 mL) under cooling with ice, and the reaction solution was stirred for 1 hour under cooling with ice. After addition of saturated aqueous ammonium chloride, the reaction solution was extracted with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=9/1) to give the desired product as a pale yellow oil (0.64 g, yield 80%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.34 (s, 9H), 1.58-1.60 (m, 3H), 3.24 (bs, 1H), 3.48 (s, 3H), 4.83-4.85 (m, 1H), 4.92-4.95 (m, 2H), 7.08 (s, 1H), 7.38-7.42 (m, 2H), 7.54-7.57 (m, 2H).
  • LC/MS (ES+) 343 (Na+ adduct).
    • Reference Synthetic Example 28 Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene
  • From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-formylthiophene (0.75 g, 2.4 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 27 as a pale yellow oil (0.76 g, yield 95%).
  • 1H-NMR (ppm in CDCl3) δ 1.57-1.62 (m, 3H), 3.05 (bs, 1H), 3.50 (s, 3H), 4.82-4.85 (m, 1H), 4.90-4.95 (m, 2H), 7.17 (d, J=2.5 Hz, 1H), 7.53-7.59 (m, 2H), 7.77 (s, 1H).
    • Reference Synthetic Example 29 Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene
  • From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.79 g, 2.5 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 27 as a yellow oil (0.76 g, yield 92%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.59 (d, J=6.3 Hz, 3H), 3.09 (bs, 1H), 3.48 (s, 3H), 4.83 (d, J=6.3 Hz, 1H), 4.92 (s, 2H), 7.20 (s, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.76 (d, J=8.4 Hz, 2H).
    • Reference Synthetic Example 30 Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-methyl carbonylthiophene
  • 2-(4-t-Butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.64 g, 2.0 mmol) in dichloromethane (13 mL) was stirred with celite (2.0 g) and pyridinium chlorochromate (0.86 g, 4.0 mmol) at room temperature for 1 hour. The reaction solution was filtered through celite, and the filtrate was concentrated and purified by silica gel column chromatography (n-hexane/ethyl acetate=1/1) to give the desired product as a brown solid (0.53 g, yield 83%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.34 (s, 9H), 2.57 (s, 3H), 3.23 (s, 3H), 4.93 (s, 2H), 7.41-7.44 (m, 2H), 7.57-7.61 (m, 2H), 7.88 (s, 1H).
    • Reference Synthetic Example 31 Synthesis of 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene
  • From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.76 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 30 as a colorless solid (0.62 g, yield 81%).
  • 1H-NMR (ppm in CDCl3)
  • δ 2.56 (s, 3H), 3.27 (s, 3H), 4.98 (s, 2H), 7.46-7.54 (m, 2H), 7.84 (d, J=1.9 Hz, 1H), 7.95 (s, 1H).
    • Reference Synthetic Example 32 Synthesis of 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene
  • From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.76 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 30 as a yellow oil (0.64 g, yield 84%).
  • 1H-NMR (ppm in CDCl3)
  • δ 2.57 (s, 3H), 3.20 (s, 3H), 4.96 (s, 2H), 7.67 (d, J=8.6 Hz, 2H), 7.82 (d, J=8.6 Hz, 2H), 7.98 (s, 1H).
    • Reference Synthetic Example 33 Synthesis of 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene
  • From 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.53 g, 1.7 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a yellow solid (0.38 g, yield 80%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.33 (s, 9H), 2.56 (s, 3H), 7.40-7.44 (m, 2H), 7.69-7.74 (m, 2H), 7.85 (s, 1H), 10.28 (s, 1H).
  • LC/MS (ES+) 275.
    • Reference Synthetic Example 34 Synthesis of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene
  • From 2-(3,4-dichlorophenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.62 g, 1.9 mmol), the desired product was obtained in the same manner as in Reference. Synthetic Example 25 as a yellow solid (0.31 g, yield 57%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 2.58 (s, 3H), 7.65-7.66 (m, 2H), 7.97 (d, J=1.0 Hz, 1H), 8.71 (s, 1H), 10.59 (s, 1H).
    • Reference Synthetic Example 35 Synthesis of 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene
  • From 2-(4-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.64 g, 1.9 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a yellow solid (0.47 g, yield 86%).
  • 1H-NMR (ppm in CDCl3)
  • δ 2.59 (s, 3H), 7.63 (d, J=8.3 Hz, 2H), 7.91 (d, J=8.3 Hz, 2H), 7.96 (s, 1H), 10.57 (s, 1H).
  • LC/MS (ES+) 287.
    • Reference Synthetic Example 36 Synthesis of oxo(phenyl)acetaldehyde methylhydrazone
  • A mixed solution of methylhydrazine (0.554 mL, 10.5 mmol)/acetic acid (1 mL)/water (7.6 mL) was added to phenylglyoxal (1.34 g, 10 mmol) in water (130 mL), and the mixture was stirred at room temperature for 20 hours. The reaction solution was extracted with chloroform, and the extract was dried, filtered, evaporated and dried by means of a vacuum pump to give oxo(phenyl)acetaldehyde methylhydrazone (1.44 g (crude), yield 89%) as a yellow solid.
    • Reference Synthetic Example 37 Synthesis of 4-hydrazinocarbonylmethyl benzoate
  • The known procedure disclosed in the literature (Synthetic Communications, 28(7), 1223-1231, (1998)) was followed using monomethyl terephthalate and tetramethylfluoroformamidinium hexafluorophosphate to give 1.36 g of the desired product as a colorless solid (yield 70%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.86 (s, 3H), 4.56 (s, 2H), 7.93 (d, J=8.3 Hz, 2H), 8.02 (d, J=8.3 Hz, 2H), 9.96 (bs, 1H).
    • Reference Synthetic Example 38 Synthesis of 5-methoxycarbonyl-2-thiophenecarboxylic acid
  • Thiophene-2,5-dicarboxylic acid (1.72 g, 10 mmol) and sodium carbonate (3.18 g, 30 mmol) suspended in dimethylformamide (25 mL) were stirred with methyl iodide (623 μL) at room temperature overnight. The sodium salt of the desired product was extracted with water, and 12 M hydrochloric acid was added to the combined aqueous layer. The desired product was extracted with ethyl acetate, and the combined organic layer was washed with saturated aqueous ammonium chloride, dried over anhydrous magnesium sulfate and purified by silica gel column chromatography to give 0.49 g of the desired product as a colorless solid (yield 28%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.93 (s, 3H), 7.77 (d, J=4.2 Hz, 1H), 7.83 (d, J=4.2 Hz, 1H).
  • LC/MS (ESI) 186(M+).
    • Reference Synthetic Example 39 Synthesis of methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate
  • The known procedure disclosed in the literature (J. Heterocyclic Chem., 28, 17, (1991).) was followed using 5-methoxycarbonyl-2-thiophenecarboxylic acid synthesized in Reference Synthetic Example 38, thionyl chloride and hydrazine monohydrate to give 144 mg of the desired product as a white solid (yield 72%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.84 (s, 3H), 4.57 (brs, 2H), 7.72 (d, J=4.2 Hz, 1H), 7.79 (d, J=4.2 Hz, 1H), 10.06 (brs, 1H).
  • LC/MS (ESI) 200(e).
    • Reference Synthetic Example 40 Synthesis of methyl 2-nitro-4-hydrazinocarbonylbenzoate
  • From 4-methoxycarbonyl-3-nitrobenzoic acid, thionyl chloride and hydrazine monohydrate, 758 mg of the desired product was obtained in the same manner as in Reference Synthetic Example 39 as a white solid (yield 79%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.88 (s, 3H), 4.67 (brs, 2H), 7.96 (d, J=7.8 Hz, 1H), 8.24 (dd, J=1.8, 7.8 Hz, 1H), 8.44 (d, J=1.8 Hz, 1H).
  • LC/MS (ESI) 239(M+).
    • Reference Synthetic Example 41 Synthesis of methyl 2-chloro-4-hydrazinocarbonylbenzoate 1) Synthesis of 3-chloro-4-methoxycarbonylbenzoic acid
  • To 3-amino-4-methoxycarbonylbenzoic acid (0.98 g, 5 mmol) suspended in 12 M hydrochloric acid (25 mL) and acetic acid (25 mL), an aqueous solution (10 mL) of sodium nitrite (0.35 g, 5 mmol) was added at −10° C., and the resulting solution was stirred for 30 minutes. The solution was added to copper chloride (I) (0.99 g, 10 mmol) in 12 M hydrochloric acid (25 mL) at −10° C., and the resulting reaction mixture was stirred at room temperature for 1 hour. After addition of ethyl acetate, the reaction mixture was washed with water, dried over magnesium sulfate, filtered through celite and purified by silica gel column chromatography to give 0.44 g of the desired product as a colorless solid (yield 39%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.98 (s, 3H), 7.89 (d, J=8.1 Hz, 1H), 8.02 (dd, J=1.5, 8.1 Hz, 1H), 8.17 (d, J=1.5 Hz, 1H).
  • LC/MS (ESI) 214 (M+ 35Cl), 216 (M+ 37Cl).
    • 2) Synthesis of methyl 2-chloro-4-hydrazinocarbonylbenzoate
  • From 3-chloro-4-methoxycarbonylbenzoic acid, thionyl chloride and hydrazine monohydrate, 423 mg of the desired product was obtained in the same manner as in Reference Synthesis Example 39 as a while solid (yield 93%
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.88 (s, 3H), 4.63 (brs, 2H), 7.87-7.96 (m, 3H), 10.05 (brs, 1H).
  • LC/MS (ESI) 228 (M+ 35Cl), 230 (M+ 37Cl).
    • Reference Synthetic Example 42 Synthesis of methyl 2-bromo-4-hydrazinocarbonylbenzoate 1) Synthesis of 3-bromo-4-methoxycarbonylbenzoic acid
  • To 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) suspended in 48% hydrobromic acid (50 mL) and acetic acid (50 mL), an aqueous solution (20 mL) of sodium nitrite (0.69 g, 10 mmol) was added at −10° C., and the resulting solution was stirred for 30 minutes. The solution was added to copper bromide (I) (1.44 g, 10 mmol) in 48% hydrobromic acid (50 mL) at −10° C., and the resulting reaction mixture was stirred at room temperature for 1 hour. After addition of ethyl acetate, the reaction mixture was washed with water, dried over magnesium sulfate, filtered through celite and purified by silica gel column chromatography to give 1.70 g of the desired product as a colorless solid (yield 59%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.97 (s, 3H), 7.84 (d, J=8.1 Hz, 1H), 8.07 (dd, J=1.5, 8.1 Hz, 1H), 8.37 (d, J=1.5 Hz, 1H).
  • LC/MS (ESI) 258 (m+ 79Br), 260 (M+ 81Br).
    • 2) Synthesis of methyl 2-bromo-4-hydrazinocarbonylbenzoate
  • From 3-bromo-4-methoxycarbonylbenzoic acid, thionyl chloride and hydrazine monohydrate, 489 mg of the desired product was obtained in the same manner as in Reference Synthesis Example 39 as a while solid (yield 900).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.88 (s, 3H), 4.60 (brs, 2H), 7.83 (d, J=8.1 Hz, 1H), 7.90 (dd, J=1.5, 8.1 Hz, 1H), 8.13 (d, J=1.5 Hz, 1H), 10.04 (brs, 1H).
  • LC/MS (ESI) 272 (M+ 79Br), 274 (M+ 81Br).
    • Reference Synthetic Example 43 Synthesis of methyl 4-hydrazinocarbonyl-2-hydroxybenzoate 1) Synthesis of 3-hydroxy-4-methoxycarbonylbenzoic acid
  • To 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) suspended in 3 M hydrochloric acid (12.5 mL) and acetic acid (20 mL), an aqueous solution (20 mL) of sodium nitrite (0.69 g, 10 mmol) was added at −10° C., and the resulting solution was stirred for 30 minutes. The solution was added to 10% aqueous sulfuric acid (30 mL) at 0° C., and the resulting reaction mixture was heated with reflux for 1 hour. The desired product was extracted with ethyl acetate, and the extract was dried over magnesium sulfate and purified by silica gel column chromatography to give 1.04 g of the desired product as a white solid (yield 53%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.86 (s, 3H), 7.43 (d, J=8.1 Hz, 1H), 7.49 (s, 1H), 7.75 (d, J=8.1 Hz, 1H), 10.55 (brs, 1H).
  • LC/MS (ESI) 196 (M+).
    • 2) Synthesis of methyl 4-hydrazinocarbonyl-2-hydroxybenzoate
  • From 3-hydroxy-4-methoxycarbonylbenzoic acid, thionyl chloride and hydrazine monohydrate, 241 mg of the desired product was obtained in the same manner as in Reference Synthesis Example 39 as a while solid (yield 57%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.90 (s, 3H), 4.55 (brs, 2H), 7.34 (dd, J=1.5, 8.1
  • Hz, 1H), 7.38 (d, J=1.5 Hz, 1H), 7.82 (d, J=8.1 Hz, 1H), 9.91 (brs, 1H), 10.52 (brs, 1H).
  • LC/MS (ESI) 210 (M+).
    • Reference Synthetic Example 44 Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene
  • From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-ethoxycarbonylthiophene (1.2 g, 3.9 mmol), the desired product was obtained in the same manner as in Reference Synthesis. Example 16 as a brown oil (1.2 g, yield 88%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.36-1.42 (m, 3H), 3.19 (s, 3H), 4.33-4.37 (m, 2H), 5.05 (s, 2H), 7.53-7.56 (m, 2H), 7.83-7.85 (m, 1H), 8.02-8.07 (m, 2H).
  • LC/MS (ES+) 383 (Na+ adduct).
    • Reference Synthetic Example 45 Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene
  • From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-ethoxycarbonylthiophene (1.2 g, 3.4 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 19 as a pale yellow oil (1.0 g, yield 95%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.50 (s, 3H), 4.57 (d, J=5.2 Hz, 2H), 4.91 (s, 2H), 7.23 (s, 1H), 7.48-7.56 (m, 2H), 7.80-7.82 (m, 1H), 7.96 (s, 1H).
  • LC/MS (ES+) 341 (Na+ adduct).
    • Reference Synthetic Example 46 Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene
  • From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-hydroxymethylthiophene (1.0 g, 3.2 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 24 as a brown oil (0.97 g, yield 96%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.29 (s, 3H), 5.03 (s, 2H), 7.53-7.62 (m, 2H), 7.83-8.06 (m, 3H), 9.91 (s, 1H).
  • LC/MS (ES+) 339 (Na+ adduct).
    • Reference Synthetic Example 47 Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene
  • From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-formylthiophene (0.97 g, 3.1 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 27 as a brown oil (0.97 g, yield 96%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.59-1.62 (m, 3H), 3.47 (s, 3H), 4.82-4.94 (m, 3H), 7.19 (s, 1H), 7.48-7.56 (m, 2H), 7.79-7.81 (m, 1H), 7.94 (s, 1H).
  • LC/MS (ES+) 355 (Na+ adduct).
    • Reference Synthetic Example 48 Synthesis of 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene
  • From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-(1-hydroxyethyl)thiophene (0.99 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 30 as a brown oil (0.76 g, is yield 77%).
  • 1H-NMR (ppm in CDCl3)
  • δ 2.57 (s, 3H), 3.19 (s, 3H), 4.97 (s, 2H), 7.54-7.58 (m, 2H), 7.83-8.01 (m, 3H).
  • LC/MS (ES+) 353 (Na+ adduct).
    • Reference Synthetic Example 49 Synthesis of 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene
  • From 2-(3-trifluoromethylphenyl)-3-methoxymethyloxy-4-methylcarbonylthiophene (0.76 g, 2.3 mmol), the desired product was obtained in the same manner as in Reference Synthesis Example 25 as a pale brown solid (0.59 g, yield 90%).
  • 1H-NMR (ppm in CDCl3)
  • δ 2.58 (s, 3H), 7.48-7.52 (m, 2H), 7.94-8.05 (m, 3H), 10.52 (s, 1H).
  • LC/MS (ES+) 287.
    • Reference Synthetic Example 50 Synthesis of methyl 2-acetamino-4-hydrazinocarbonylbenzoate 1) Synthesis of 3-acetamino-4-methoxycarbonylbenzoic acid
  • Acetic anhydride (1.89 mL, 20 mmol) was added to a suspension of 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) in acetic acid (10 mL), and the mixture was heated with reflux for 6 hours. After cooling, the precipitated solid was filtered to obtain 2.12 g of the desired product as a colorless solid (yield 89%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 2.13 (s, 3H), 3.87 (s, 3H), 7.71 (d, 1H, J=8.4 Hz), 7.96 (d, 1H, J=8.4 Hz), 8.68 (s, 1H), 10.51 (brs, 1H). LC/MS (ESI) 237 (M+).
    • 2) Synthesis of methyl 2-acetamino-4-hydrazinocarbonylbenzoate
  • 1-Hydroxybenzotriazole (HOBt) (270 mg, 2 mmol) and 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (WSC) (498 mg, 2.6 mmol) were added to a solution of 3-acetamino-4-methoxycarbonylbenzoic acid (474 mg, 2 mmol) in dimethylformamide (10 mL), and the mixture was stirred at room temperature for 3 hours. Hydrazine monohydrate (485 μL, 10 mmol) was further added at 0° C., and the mixture was stirred overnight at room temperature. The precipitated solid was filtered, and then washed with water to obtain 400 mg of the desired product as a white solid (yield 80%).
  • 1H-NMR (ppm in DMSO-d6)
  • 2.12 (s, 3H), 3.85 (s, 3H), 4.55 (brs, 2H), 7.55 (d, 1H, J=8.1 Hz), 7.90 (d, 1H, J=8.1 Hz), 8.49 (s, 1H), 9.92 (brs, 1H), 10.48 (brs, 1H).
    • LC/MS (ESI) 251 (M+) Reference Synthetic Example 51 Synthesis of methyl 2-fluoro-4-hydrazinocarbonylbenzoate 1) Synthesis of methyl 4-bromo-2-fluorobenzoate
  • Methyl iodide (1.49 mL, 24 mmol) was added to a suspension of 4-bromo-2-fluorobenzoic acid (4.38 g, 20 mmol) and sodium carbonate (6.36 g, 60 mmol) in dimethylformamide (50 mL), and the mixture was stirred overnight at room temperature. After completion of the reaction, ethyl acetate was added, and the mixture was washed with water and a saturated ammonium chloride aqueous solution. After drying over magnesium sulfate, concentration was carried out to obtain 4.50 g of the desired product as a colorless solid (yield 97%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.93 (s, 3H), 7.33-7.38 (m, 2H), 7.80-7.85 (m, 1H).
    • 2) Synthesis of methyl 4-benzyloxycarbonyl-2-fluorobenzoate
  • Palladium diacetate (4.5 mg, 0.02 mmol), 1,4-(bisdiphenylphosphino)butane (8.5 mg, 0.02 mmol), triethylamine (55.8 μL, 0.4 mmol) and benzyl alcohol (0.1 mL) were added to a solution of methyl 4-bromo-2-fluorobenzoate (46.6 mg, 0.2 mmol) in dimethylformamide (1 mL). In this solution, bubbling was carried out for a few minutes with carbon monoxide, and then this solution was heated at 120° C. for 0.12 hours under carbon monoxide atmosphere. After completion of the reaction, ethyl acetate was added, and the resultant product was washed with a saturated ammonium chloride aqueous solution, and purified with a silica gel column chromatography (hexane/ethyl acetate=19/1) to obtain 35.4 mg of the desired product as a yellow viscous liquid (yield 61%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.95 (s, 3H), 5.38 (s, 2H), 7.35-7.46 (m, 5H), 7.79-8.02 (m, 3H).
    • 3) Synthesis of 3-fluoro-4-methoxycarbonylbenzoic acid
  • Catalytic amount of 10 wt % palladium carbon was added to a solution of methyl 4-benzyloxycarbonyl-2-fluorobenzoate (35.4 mg, 0.123 mmol) in ethanol (2 mL), and the mixture was stirred overnight at room temperature under hydrogen atmosphere. After completion of the reaction, the mixture was filtered through celite and the filtrate was concentrated to obtain 26.0 mg of the desired product as a colorless solid (yield 100%).
  • 1H-NMR (ppm in CDCl3)
  • δ 3.97 (s, 3H), 7.83-8.06 (m, 3H).
  • LC/MS (ESI) 198 (M+).
    • 4) Synthesis of methyl 2-fluoro-4-hydrazinocarbonylbenzoate
  • From 3-fluoro-4-methoxycarbonylbenzoic acid (198 mg, 1 mmol), 1-hydroxybenzotriazole (HOBt) (135 mg, 0.1 mmol), 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (WSC) (249 mg, 1.3 mmol) and hydrazine monohydrate (73 μL, 1.5 mmol), 45.6 mg of the desired, product was obtained in the same manner as in Reference Synthesis Example 50 as a white solid (yield 22%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.87 (s, 3H), 4.60 (brs, 2H), 7.71-7.77 (m, 2H), 7.94-7.99 (m, 1H), 10.06 (brs, 1H).
  • LC/MS (ESI) 212 (M+).
    • Reference Synthetic Example 52 Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyisobutyl)thiophene
  • To a solution of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-formylthiophene (3.0 g, 10 mmol) in THF (2.5 mL), 2.0 Methyl ether solution (6.0 mL, 12 mmol) of isopropylmagnesium bromide was added dropwise under cooling with ice, followed by stirring for 2.5 hours under cooling with ice. A saturated ammonium chloride aqueous solution was added to the reaction solution, and then extraction was carried out with ethyl acetate, and the organic layer was washed with a saturated sodium chloride solution and then dried over anhydrous sodium sulfate. The obtained organic layer was concentrated, and then purification was carried out with a silica gel column chromatography (n-hexane/ethyl acetate=3/1) to obtain the desired product as a pale yellow oil (1.18 g, yield 340).
  • 1H-NMR (ppm in CDCl3) δ 0.91 (d, J=6.6 Hz, 3H), 1.10 (d, J=6.6 Hz, 3H), 1.34 (s, 9H), 2.15-2.25 (m, 1H), 3.46 (s, 3H), 4.35 (d, J=8.0 Hz, 1H), 4.86 (s, 2H), 7.04 (s, 1H), 7.39 (d, J=8.8 Hz, 2H), 7.56 (d, J=8.8 Hz, 2H).
  • LC/MS (ES−) 303.
    • Reference Synthetic Example 53 Synthesis of 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-isopropylcarbonylthiophene
  • Using 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(1-hydroxyisobutyl)thiophene (1.07 g, 3.07 mmol) as the starting material, the desired product was obtained in the same manner as in Reference Synthetic Example 30 as a brown oil (0.85 g, yield 80%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.20 (s, 3H), 1.23 (s, 3H), 1.34 (s, 9H), 3.21 (s, 3H), 3.39-3.45 (m, 1H), 4.92 (s, 2H), 7.42 (d, J=8.7 Hz, 2H), 7.61 (d, J=8.7 Hz, 2H), 7.83 (s, 1H).
  • LC/MS (ES+) 369 (Na+ adduct).
    • Reference Synthetic Example 54 Synthesis of 2-(4-t-butylphenyl)-3-hydroxy-4-isopropylcarbonylthiophene
  • Using 2-(4-t-butylphenyl)-3-methoxymethyloxy-4-(isopropylcarbonyl)thiophene (0.85 g, 2:5 mmol) as the starting material, the desired product was obtained in the same manner as in Reference Synthetic Example 25 as a pale brown solid (0.42 g, yield 56%).
  • 1H-NMR (ppm in CDCl3)
  • δ 1.26 (s, 3H), 1.28 (s, 3H), 1.34 (s, 9H), 3.36-3.41 (m, 1H), 7.42 (d, J=8.8 Hz, 2H), 7.72 (d, J=8.8 Hz, 2H), 7.89 (s, 1H), 10.50 (s, 1H).
  • LC/MS (ES+) 303.
    • Reference Synthetic Example 55 Synthesis of 2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-methyl carbonyl thiophene
  • 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (2.66 g, 9.7 mmol), N-bromosuccinimide (1.73 g, 9.7 mmol) and benzoyl peroxide (153 mg, 0.63 mmol) were heated with reflux for 2 hours in 65 ml of chloroform. Water was added, and the reaction solution was extracted three times with chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, and then dried over anhydrous sodium sulfate. The obtained organic layer was concentrated, and then purified with a silica gel column chromatography (n-hexane/chloroform=3/2) to obtain the desired product a a yellow solid (2.93 g, yield 86%).
  • 1H-NMR (ppm in CDCl3)
  • δ=1.33 (s, 9H), 2.79 (s, 3H), 7.39-7.43 (m, 2H), 7.62-7.66 (m, 2H), 10.91 (s, 1H).
  • LC/MS (ES−) 351, 353.
    • Reference Synthetic Example 56 Synthesis of methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate 1) Synthesis of methyl 4-amino-2-nitrobenzoate
  • To a suspension of 4-amino-2-nitrobenzoic acid (200 mg, 1.10 mmol) synthesized in accordance with the synthesis method described in WO96/35666 and sodium carbonate (349 mg, 3.29 mmol) in dimethylformamide (5.5 mL), methyl iodide (0.21 ml) was added, and the mixture was stirred overnight at room temperature. Water was added to the reaction solution, and extraction was carried out with ethyl acetate, and the combined organic layer was washed with a saturated ammonium chloride aqueous solution and a saturated sodium chloride aqueous solution, followed by drying over anhydrous sodium sulfate. By concentrating the obtained organic layer, 216 mg of the desired product was obtained as a yellow solid (yield 100%).
  • 1H-NMR (ppm in CDCl3)
  • δ 7.69 (d, J=8.5 Hz, 1H), 6.85 (d, J=2.4 Hz, 1H), 6.77 (dd, J=2.4, 8.5 Hz, 1H), 4.31 (bs, 2H), 3.84 (s, 3H).
  • LC/MS (ESI) 196.
    • 2) Synthesis of 4-methoxycarbonyl-3-nitrophenyl isothiocyanate
  • A solution of the above synthesized methyl 4-amino-2-nitrobenzoate (50 mg, 0.25 mmol) and 1,1′-thiocarbonyldi-2(1H)-pyridone (59 mg, 0.25 mmol) in dichloromethane (4.2 ml) was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was evaporated, followed by purification with a silica gel column chromatography to obtain 42 mg of the desired product as a colorless oil (yield 69%).
  • 1H-NMR (ppm in CDCl3)
  • δ 7.79 (d, J=8.3 Hz, 1H), 7.66 (d, J=2.1 Hz, 1H), 7.47 (dd, J=2.1, 8.3 Hz, 1H), 3.92 (s, 3H).
  • LC/MS (ES−) 224 (M+−CH2).
    • 3) Synthesis of methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate
  • A solution of the above synthesized 4-methoxycarbonyl-3-nitrophenyl isothiocyanate (149 mg, 0.62 mmol) in tetrahydrofuran (2.2 ml) was added dropwise to a solution of hydrazine monohydrate (94 mg, 1.87 mmol) in tetrahydrofuran (4.0 ml) at 0° C. over 20 minutes.
  • After stirring at 0° C. for further 40 minutes, water was added, and the precipitated solid was filtered to obtain 142 mg of the desired product as a colorless solid (yield 85%).
  • 1H-NMR (ppm in DMSO)
  • δ 9.67 (bs, 1H), 8.71 (bs, 1H), 8.18-8.21 (m, 1H), 7.76-7.83 (m, 2H), 3.82 (s, 3H).
  • LC/MS (ESI) 270.
    • Reference Synthetic Example 57 Synthesis of methyl 5-hydrazinocarbonothioylamino-2-thiophenecarboxylate 1) Synthesis of methyl 5-nitro-2-thiophenecarboxylate
  • From 5-nitrothiophene-2-carboxylic acid (3 g, 17.3 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a pale pink solid (2.97 g, yield 92%).
  • 1H-NMR (ppm in CDCl3)
  • δ 7.88 (d, J=4.3 Hz, 1H), 7.70 (d, J=4.3 Hz, 1H), 3.96 (s, 3H).
    • 2) Synthesis of 5-methoxycarbonyl-2-thiophene isothiocyanate
  • To a solution of the above synthesized methyl 5-nitro-2-thiophenecarboxylate (2.67 g, 14.3 mmol) and iron (2.63 g, 47.1 mmol) in ethanol (50 ml) and water (9.9 ml), concentrated hydrochloric acid (0.12 ml, 1.43 mmol) was added at 90° C. And the mixture was stirred at 90° C. for 30 minutes. After completion of the reaction, 1 M sodium hydroxide aqueous solution (1.43 ml, 1.43 mmol) was added thereto. The insolubles were filtered off, and the filtrate was concentrated and extracted with ethyl acetate, then dried over anhydrous sodium sulfate. The obtained organic layer was concentrated and dried by means of a vacuum pump. From the resulting crude solid, the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a pale yellow oil (904 mg, yield 32%).
  • 1H-NMR (ppm in CDCl3)
  • δ 7.56 (d, J=4.0 Hz, 1H), 6.83 (d, J=4.0 Hz, 1H), 3.88 (s, 3H).
  • LC/MS (ES+) 199.
    • 3) Synthesis of methyl 5-hydrazinocarbonothioylamino-2-thiophenecarboxylate
  • From the above synthesized methyl 5-methoxycarbonyl-2-thiophene isothiocyanate (484 mg, 2.43 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a colorless solid (435 mg, yield 77%).
  • 1H-NMR (ppm in DMSO)
  • δ 9.63 (bs, 1H), 7.55-7.57 (m, 1H), 7.12 (bs, 1H), 6.95 (bs, 1H), 3.76 (s, 3H).
  • LC/MS (ESI) 231.
    • Reference Synthetic Example 58 Synthesis of methyl 4-hydrazinocarbonothioylamino-2-chlorobenzoate 1) Synthesis of methyl 4-amino-2-chlorobenzoate
  • From 4-amino-2-chlorobenzoic acid (500 mg, 2.91 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a pale brown solid (535 mg, yield 99%).
  • 1H-1-NMR (ppm in CDCl3)
  • δ7.78 (d, J=8.5 Hz, 1H), 6.70 (d, J=2.2 Hz, 1H), 6.53 (dd, J=2.2 Hz, 8.5 Hz, 1H), 4.07 (bs, 2H), 3.86 (s, 3H). LC/MS (ES+) 185.
    • 2) Synthesis of 4-methoxycarbonyl-3-chlorophenyl isothiocyanate
  • From the above synthesized methyl 4-amino-2-chlorobenzoate (505 mg, 2.72 mmol), the desired product was obtained in the same manner as in Reference Synthetic Example 56 as a colorless solid (424 mg, yield 69%).
  • 1H-NMR (ppm in CDCl3)
  • δ 7.87 (d, J=8.3 Hz, 1H), 7.31 (d, J=2.0 Hz, 1H), 7.15 (dd, J=2.0 Hz, 8.3 Hz, 1H), 3.93 (s, 3H).
  • LC/MS (ES+) 227.
    • 3) Synthesis Of methyl 4-hydrazinocarbonothioylamino-2-chlorobenzoate
  • From the above synthesized 4-methoxycarbonyl-3-chlorophenyl isothiocyanate (420 mg, 1.85 mmol), the desired product was obtained in the same manner as in Reference. Synthetic Example 56 as a colorless solid (364 mg, yield 76%).
  • 1H-NMR (ppm in DMSO)
  • δ 9.54 (bs, 1H), 8.24 (bs, 1H), 7.77-7.84 (m, 3H), 3.83 (s, 3H).
  • LC/MS (ESI) 259.
    • Reference Synthetic Example 59-66
  • Table 15 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the reference synthetic example (R.S.E.) 33, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • TABLE 15
    yields O.P. R.T.
    R.S.E. (%) shapes L.C. ESI+ ESI− (min)
    59 48 pale brown solid 2 297/299 295/297 4.54
    60 73 yellow solid
    61 83 yellow solid 9 303 301 3.34
    62 93 brown solid 5 255 253 4.49
    63 50 yellow solid 9 237 235 2.99
    64 44 green solid 2 237 235 4.22
    65 53 yellow solid 2 247 245 4.52
    66 55 pale green solid 2 253/255 251/253 4.49
    • Reference Synthetic Example 67 Synthesis of 2-(3,4-dichlorophenyl)-4-(1-hydrorazonoethyl)thiophen-3-ol
  • To a suspension of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (300 mg, 1.05 mmol) in isopropanol (20 mL) was added hydrazine monohydrate (61 μL, 1.25 mmol). The reaction mixture was refluxed for 1.5 hours, stirred at room temperature for 0.5 hour and at 0° C. for 1 hour. The precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 100%)
  • 1H-NMR (DMSO-d6) δ(ppm): 2.10 (s, 3H), 6.63 (br s, 2H), 7.58 (s, 2H), 7.61 (s, 1H), 7.98 (s, 1H), 12.88 (s, 1H.)
  • LC/MS: condition 8, retention time 4.95 (min)
  • LC/MS (ESI+) m/z; 301, 303 [M+1]+
  • LC/MS (ESI−) m/z; 299, 301 [M−1]−
    • Reference Synthetic Example 68-75
  • Table 16 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the reference synthetic example (R.S.E.) 67, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • TABLE 16
    yields O.P. R.T.
    R.S.E. (%) shapes L.C. ESI+ ESI− (min)
    68 50 pale yellow solid 3 267/269 265/267 3.52
    69 89 pale yellow solid 2 299 297 3.49
    70 72 pale yellow solid
    71 100 pale yellow solid
    72 100 yellow solid 9 263 261 4.85
    73 100 pale yellow solid 3 311/313 309/311 3.57
    74 93 yellow solid 3 317 315 3.62
    75 79 pale yellow solid 3 261 259 3.50

    The structural formulae of the compounds obtained in the Reference Synthetic Example 59-75 are given below.
  • Figure US20140051857A1-20140220-C00039
    Figure US20140051857A1-20140220-C00040
    Figure US20140051857A1-20140220-C00041
    Figure US20140051857A1-20140220-C00042
    • Synthetic Example 1 Synthesis of 4-[(2-{(1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (1.525 mmol, 152.7 mg) synthesized in Reference Synthetic Example 1 and (3,4-dichlorophenyl)(oxo)acetaldehyde (1.525 mmol, 310 mg) synthesized in Reference Synthetic Example 3 were dissolved in acetic acid (10 mL) and stirred at 110° C. for 1.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump, resolved by silica gel thin layer chromatography (n-hexane/AcOEt=3/2) and purified by silica gel thin layer chromatography (n-hexane/AcOEt=2/1) to give the desired product as a yellow solid (57.8 mg, yield 13%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.25 (s, 1H), 7.58 (br.s, 1H), 7.55 (br.s, 1H), 7.33 (br.dd, 1H), 3.92 (s, 3H), 2.58 (s, 3H).
  • 13C-NMR (ppm in CDCl3)
  • δ 198.1, 143.8, 135.6, 133.2, 132.7, 130.9, 130.4, 127.8, 127.6, 125.8, 39.3, 25.6.
  • LC-MS (ESI) 284 (M+).
    • 2) Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate
  • 1-[5-(3,4-Dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.1336 mmol, 38 mg), 4-hydrazinocarbonylmethyl benzoate (0.1336 mmol, 26 mg) and p-tosylic acid monohydrate (30 mol %, 6.9 mg) were dissolved in isopropyl alcohol (2.5 mL) and stirred 100° C. for 3.5 hours. Then, the reactor was cooled to 0° C., and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a white solid (30.5 mg, yield 50%.
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.46 (s, 1H), 9.95 (s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04 (ABq, J=8.3 Hz, 2H), 7.86 (d, J=2.0 Hz, 1H), 7.80 (d, J=8.3 Hz, 1H), 7.61 (dd, J=2.0, 8.3 Hz, 1H), 3.90 (s, 3H), 3.90 (s, 3H), 2.45 (s, 3H).
  • LC-MS (ESI) 460 (M+).
  • 3) Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate (0.0518 mmol, 23.9 mg), methanol (3 mL) was added, and 1 M aqueous sodium hydroxide (0.259 mmol, 0.259 mL) was added, at room temperature. After 20 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (0.259 mmol, 0.259 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (8.7 mg, yield 370).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.43 (s, 1H), 9.96 (s, 1H), 8.13-7.98 (multi, 4H), 7.86-7.78 (multi, 2H), 7.62-7.51 (multi, 1H), 3.90-3.87 (multi, 3H), 2.46-2.45 (multi, 3H).
  • LC-MS (ESI) 446 (M+).
    • Synthetic Example 2 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(3,4-Dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.139 mmol, 39.7 mg) synthesized in Synthetic Example 1 and 4-hydrazinocarbonothioylaminobenzoic acid (0.139 mmol, 29.4 mg) were stirred with dimethylformamide (4 mL) and two drops of concentrated hydrochloric acid at room temperature for 22 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (39.5 mg, yield 59%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.36 (s, 1H), 10.33 (s, 1H), 9.15 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.85-7.83 (multi, 2H), 7.79 (ABq, J=8.6 Hz, 2H), 7.58 (d, J=8.4 Hz, 1H), 3.85 (s, 3H), 2.39 (s, 3H).
  • LC-MS (ESI) 477 (M+).
    • Synthetic Example 3 Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (46.375 mmol, 4.64 g) synthesized in Reference Synthetic Example 1 and (4-tert-butylphenyl)(oxo)acetaldehyde synthesized in Reference Synthetic Example 4 (46.375 mmol, 8.82 g) were dissolved in acetic acid (140 mL) and stirred at 100° C. for 2 hours. The reactor was cooled to room temperature, and after addition of water (100 mL) and saturated aqueous sodium chloride (50 mL), it was extracted with chloroform three times. The resulting organic layer was dried and filtered, and the solvent was evaporated. The residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=4/1) to give the desired product as a yellow solid (5.79 g′, yield 46%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.16 (s, 1H, exchangeable with D2O), 7.51 (ABq, J=8.4 Hz, 2H), 7.40 (ABq, J=8.4 Hz, 2H), 3.91 (s, 3H), 2.58 (s, 3H), 1.35 (s, 9H).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 8.5.0 (s, 1H), 7.53 (ABq, J=8.6 Hz, 2H), 7.44 (ABq, J=8.6 Hz, 2H), 3.83 (s, 3H), 2.46 (s, 3H), 1.32 (s, 9H).
  • 13C-NMR (ppm in CDCl3)
  • δ 198.2, 151.6, 143.4, 135.6, 128.5, 128.3, 125.8, 124.7, 39.1, 34.7, 31.2, 25.6.
  • LC-MS (ESI) 272 (M+).
    • 2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate
  • 1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.441 mmol, 120.0 mg), 4-hydrazinocarbonylmethyl benzoate (0.441 mmol, 85.6 mg) and p-tosylic acid monohydrate (30 mol %, 22.8 mg) were dissolved in isopropyl alcohol (10 mL) and stirred at 100° C. for about 3 hours and then at 50° C. overnight. The reactor was cooled to 0° C., and the reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (145.1 mg, yield 73%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.98 (s, 1H), 8.78 (br.s, 1H), 8.16-8.13 (multi, 2H), 7.92-7.80 (multi, 2H), 7.51-7.32 (multi, 4H), 3.95-3.88 (multi, 6H), 2.54 and 2.44 (sx2, 3H), 1.35 (s, 9H).
  • LC-MS (ESI) 448 (M+).
  • 3) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate (0.0816 mmol, 36.6 mg), methanol (2.5 mL) was added, and then 1 M aqueous sodium hydroxide (0.408 mmol. 0.408 mL) was added. After 22 hours of stirring at room temperature, 1 M hydrochloric acid (0.408 mmol, 0.408 mL) and water were added. The precipitated solid was recovered by filtration, washed with water, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=5/1) to give the desired product as a yellow solid (35.0 mg, yield 99%).
  • 1H-NMR (ppm in DMSO-d6) δ 8.13-7.98 (multi, 4H), 7.59-7.43 (multi, 4H), 3.88 and 3.84 (sx2, 3H), 2.46 and 2.45 (sx2, 3H), 1.34 and 1.32 (sx2, 9H).
  • LC-MS (ESI) 434 (M+).
    • Synthetic Example 4 Synthesis of 3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]methyl benzoate
  • 1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.192 mmol, 52.2 mg) synthesized in Synthetic Example 3,3-hydrazinocarbonylmethyl benzoate (0.192 mmol, 37.2 mg) and p-tosylic acid monohydrate (30 mol %, 9.9 mg) were dissolved in isopropyl alcohol (7 mL) and stirred at 100° C. for about 15 hours. Then, the reactor was cooled to room temperature, and the reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (65.3 mg, yield 76%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.42 (s, 1H), 9.70 (s, 1H), 8.47 (s, 1H), 8.19 (br.t, 2H), 7.71 (t, J=7.7 Hz, 1H), 7.55 (ABq, J=8.7 Hz, 2H), 7.51 (ABq, J=8.7 Hz, 2H), 3.92 (s, 3H), 3.85 (s, 3H), 2.46 (s, 3H), 1.34 (s, 9H).
  • LC-MS (ESI) 448 (M+).
    • Synthetic Example 5 Synthesis of 3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To 3-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]methyl benzoate (0.119 mmol, 53.4 mg), methanol (2.5 mL) was added, and then 1 M aqueous sodium hydroxide (0.595 mmol, 0.595 mL) was added. After 1 hour of stirring at room temperature and 1 hour of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (0.595 mmol, 0.595 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting mixture was resolved by silica gel thin layer chromatography (CHCl3/MeOH=10/1) to give the desired product as a pale yellow solid (34 mg, yield 66%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.41 (s, 1H), 9.72 (s, 1H), 8.55 and 8.46 (sx2, 1H), 8.16-8.14 (multi, 2H), 7.71-7.63 (multi, 1H), 7.58-7.50 (multi, 4H), 3.94 and 3.85 (sx2, 3H), 2.46 (s, 3H), 1.34 (s, 9H).
  • LC-MS (ESI). 434 (M+).
    • Synthetic Example 6 Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.163 mmol, 44.4 mg) synthesized in Synthetic Example 3 and 4-hydrazinocarbonothioylaminobenzoic acid (0.163 mmol, 34.4 mg) were stirred with dimethylformamide (3 mL) and two drops of concentrated hydrochloric acid at room temperature for 20 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (37 mg, yield 48%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.88 (s, 1H), 10.34 (s, 1H), 8.86 (s, 1H), 7.95-7.84 (multi, 4H), 7.59-7.47 (multi, 4H), 3.83 and 3.81 (sx2, 3H), 2.46 and 2.39 (sx2, 3H), 1.34 and 1.33 (sx2, 9H).
  • LC-MS (ESI) 465 (M+).
    • Synthetic Example 7 Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid 1) Synthesis of 1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal ethylhydrazone (4.736 mmol, 540.6 mg) synthesized in Reference Synthetic Example 2 and (4-tert-butylphenyl)(oxo)acetaldehyde (4.736 mmol, 901.0 mg) synthesized in Reference Synthetic Example 4 were dissolved in acetic acid (20 mL) and stirred at 100° C. for about 3.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel thin layer chromatography (n-hexane/AcOEt=1/2, 3/1 and 4/1) to give the desired product as an orange liquid (212 mg, yield 16%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.12 (s, 1H), 7.50 (ABq, J=8.6 Hz, 2H), 7.36 (ABq, J=8.6 Hz, 2H), 4.19 (q, J=7.2 Hz, 2H), 2.59 (s, 3H), 1.42 (t, J=7.2 Hz, 3H), 1.36 (s, 9H).
  • LC-MS (ESI) 286 (M+).
    • 2) Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
  • 1-[5-(4-tert-Butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.1718 mmol, 49.2 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.1718 mmol, 36.3 mg) were stirred with dimethylformamide (3 mL) and two drops of concentrated hydrochloric acid at room temperature for 21 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (59 mg, yield 72%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.89 (s, 1H), 10.33 (s, 1H), 8.77 (s, 1H), 7.94-7.84 (multi, 4H), 7.60-7.41 (multi, 4H), 4.08 (q, J=7.2 Hz, 2H), 2.47 and 2.41 (sx2, 3H), 1.34 and 1.33 (sx2, 9H), 1.27 (t, J=7.2 Hz, 3H).
  • LC-MS (ESI) 479 (M+).
    • Synthetic Example 8 Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid 1) Synthesis of 1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal benzylhydrazone (2.314 mmol, 408 mg) synthesized in the same manner as in Reference Synthetic Examples 1 and 2 and (4-tert-butylphenyl)(oxo)acetaldehyde (1.929 mmol, 366.9 mg) synthesized in Reference Synthetic Example 4 were dissolved in acetic acid (9 mL) and stirred at 100° C. for about 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/AcOEt=3/1, and 4/1) to give the desired product as a yellow solid (74.1 mg, yield 11%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.15 (s, 1H), 7.43-7.40 (multi, 2H), 7.30-7.25 (multi, 5H), 7.06-7.03 (multi, 2H), 5.34 (s, 2H), 2.60 (s, 3H), 1.32 (s, 9H).
  • LC-MS (ESI) 348 (M+).
    • 2) Synthesis of 4-{[(2-{1-[5-(4-tert-butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(4-tert-Butylphenyl)-1-benzyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.218 mmol, 76 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.218 mmol, 46 mg) were stirred with dimethylformamide (3.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 22 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (83 mg, yield 70%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.94 (br.s, 1H), 10.36-10.34 (br.s, 1H), 8.90 (s, 1H), 7.94-7.85 (multi, 4H), 7.56-7.47 (multi, 2H), 7.39-7.21 (multi, 5H), 7.09-6.95 (multi, 2H), 5.34 and 5.29 (sx2, 2H), 2.47 and 2.40 (sx2, 3H), 1.33 and 1.30 (sx2, 9H).
  • LC-MS (ESI) 541 (M+).
    • Synthetic Example 9 Synthesis of 4-{[(2-{1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1) Synthesis of 1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (8.18 mmol, 819 mg) synthesized in Reference Synthetic Example 1 and (3,4-dimethylphenyl)(oxo)acetaldehyde (7.57 mmol, 1.227 g) synthesized in Reference Synthetic Example 5 were dissolved in acetic acid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and subjected to silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1) to give the crude product. The crude product was stirred with CHCl3/n-hexane for a while, and then recovered by filtration. The filtered solid was combined with a solid obtained by silica gel thin layer chromatography purification (n-hexane/AcOEt=4/1) of the filtrate to give the desired product as an orange solid (237.5 mg, yield 13%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.13 (br.s, 1H), 7.23-7.15 (multi, 3H), 3.88 (s, 3H), 2.58 (s, 3H), 2.34-2.31 (multi, 6H).
  • LC-MS (ESI) 244 (M+).
  • 2) Synthesis of 4-{[(2-{1-[5-(3,4-dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(3,4-Dimethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.2423 mmol, HPLC purity 84.3%, 70.2 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.2423 mmol, 51.2 mg) were stirred with dimethylformamide (3 mL) and three drops of concentrated hydrochloric acid at room temperature for 8.5 hours. After addition of, water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (72.1 mg, yield 68%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.84 (br.s, 1H), 10.33 (s, 1H), 8.82 and 8.32 (sx2, 1H), 7.94-7.83 (multi, 4H), 7.32-7.23 (multi, 3H), 3.81 and 3.79 (sx2, 3H), 2.46 and 2.39 (sx2, 3H), 2.30-2.29 (multi, 6H).
  • LC-MS (ESI) 437 (Mt).
    • Synthetic Example 10 Synthesis of 4-{[(2-{1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid 1) Synthesis, of 1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (8.6 mmol, 861 mg) synthesized in Reference Synthetic Example 1 and (4-n-pentylphenyl) (oxo)acetaldehyde (8.6 mmol, 1.757 g) synthesized in Reference Synthetic Example 6 were dissolved in acetic acid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1) to give the desired product as an orange solid (252.5 mg, yield 10.3%, crude).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.16 (br.s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.29 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.70-2.62 (multi, 2H), 2.58 (s, 3H), 1.70-1.60 (multi, 2H), 1.39-1.32 (multi, 4H), 0.93-0.87 (multi, 3H).
  • LC-MS (ESI) 286 (M+).
    • 2) Synthesis of 4-{[(2-{1-[5-(4-n-pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(4-n-Pentylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.2381 mmol, HPLC purity 86.3%, 79.0 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.2381 mmol, 50.3 mg) were stirred with dimethylformamide (3 mL) and three drops of concentrated hydrochloric acid at room temperature for 8.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (86.4 mg, yield 76%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.90 (br.s, 1H), 10.34 (s, 1H), 8.85 (s, 1H), 7.94-7.84 (multi, 4H), 7.48-7.32 (multi, 4H), 3.82 and 3.80 (sx2, 3H), 2.65-2.60 (multi, 2H), 2.46 and 2.39 (sx2, 3H), 1.64-1.57 (multi, 2H), 1.34-1.30 (multi, 4H), 0.90-0.86 (multi, 3H).
  • LC-MS (ESI) 479 (M+).
    • Synthetic Example 11 Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid 1) Synthesis of 1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (8.540 mmol, 855 mg) synthesized in Reference Synthetic Example 1 and (4-trifluoromethylphenyl)(oxo)acetaldehyde (6.432 mmol, 1.3 g) synthesized in Reference Synthetic Example 7 were dissolved in acetic acid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1) to give the desired product as an orange solid (157.3 mg, yield 8.6%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.28 (s, 1H), 7.75 (ABq, J=8.3 Hz, 2H), 7.62 (ABq, J=8.3 Hz, 2H), 3.95 (s, 3H), 2.59 (s, 3H).
  • LC-MS (ESI) 284 (M+).
    • 2) Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(4-trifluoromethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.1694 mmol, HPLC purity 80%, 60.2 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.1694 mmol, 35.8 mg) were stirred with dimethylformamide (3 mL) and three drops of concentrated hydrochloric acid at room temperature for 8.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. Chloroform/n-hexane was added to the resulting solid, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (72.2 mg, yield 89%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.93 (br.s, 1H), 10.36 and 10.35 (br.sx2, 1H), 9.14 (s, 1H), 7.95-7.80 (multi, 8H), 3.88 (s, 3H), 2.47 and 2.41 (sx2, 3H).
  • LC-MS (ESI) 477 (M+).
    • Synthetic Example 12 Synthesis of 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoic acid 1) Synthesis of methyl 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(3,4-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.365 mmol, 105.8 mg), 4-hydrazinocarbonylmethyl benzoate (0.365 mmol, 70.9 mg) and p-tosylic acid monohydrate (30 mol %, 18.9 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 19 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol 10/1) to give the desired product as a white solid (21.7 mg, yield 14%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.39 (br.s, 1H), 9.66 (br.s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04 (ABq, J=8.3 Hz, 2H), 7.34 (br.s, 1H), 7.28 (br.s, 2H), 3.90 (s, 3H), 3.83 (s, 3H), 2.45 (s, 3H), 2.30 (s, 3H), 2.28 (s, 3H).
  • LC-MS (ESI) 420 (M+).
    • 2) Synthesis of 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[5-(3,4-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.051 mmol, 21.6 mg), methanol (2.0 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.257 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.257 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (17.5 mg, yield 84%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.35 (br.s, 1H), 9.69 (br.s, 1H), 8.07-7.96 (multi, 4H), 7.88-7.26 (multi, 3H), 3.82 (s, 3H), 2.45 (s, 3H), 2.30 (s, 3H), 2.28 (s, 3H).
  • LC-MS (ESI) 406 (M+).
    • Synthetic Example 13 Synthesis of 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[4-Hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethanone (0.309 mmol, 102.4 mg), 4-hydrazinocarbonylmethyl benzoate (0.309 mmol, 59.9 mg) and p-tosylic acid monohydrate (30 mol %, 15.9 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 20 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a white solid (87.9 mg, yield 62%).
  • 1H-NMR (ppm in DMSO-d6) δ 11.27 (br.s, 1H), 9.94 (br.s, 1H), 8.10-8.05 (multi, 4H), 7.48 (ABq, J=8.1 Hz, 2H), 7.34 (ABq, J=8.1 Hz, 2H), 3.90 (s, 3H), 3.84 (s, 3H), 2.63 (t, J=7.1 Hz, 2H), 2.44 (s, 3H), 1.62 (multi, 2H), 1.33-1.32 (multi, 4H), 0.88 (t, J=7.1 Hz, 3H).
  • LC-MS (ESI) 462 (M+).
    • 2) Synthesis of 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-pentylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.121 mmol, 66.5 mg), methanol (3.5 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.605 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.605 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (40.4 mg, yield 74%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.36 (br.s, 1H), 9.69 (br.s, 1H), 8.07 (ABq, J=8.3 Hz, 2H), 8.01 (ABq, J=8.3 Hz, 2H), 7.48 (ABq, J=8.0 Hz, 2H), 7.34 (ABq, J=8.0 Hz, 2H), 3.84 (s, 3H), 2.63 (t, J=7.7 Hz, 2H), 2.45 (s, 3H), 1.62 (multi, 2H), 1.33-1.32 (multi, 4H), 0.88 (t, J=6.8 Hz, 3H).
  • LC-MS (ESI) 448 (M+).
    • Synthetic Example 14 Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid 1) Synthesis of methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate
  • 1-[4-Hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.231 mmol, 82.1 mg), 4-hydrazinocarbonylmethyl benzoate (0.231 mmol, 44.9 mg) and p-tosylic acid monohydrate (30 mol %, 11.9 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 20 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (66.5 mg, yield 63%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.46 (br.s, 1H), 9.97 (br.s, 1H), 8.11 (ABq, J=8.6 Hz, 2H), 8.04 (ABq, J=8.6 Hz, 2H), 7.89 (ABq, J=8.6 Hz, 2H), 7.84 (ABq, J=8.6 Hz, 2H), 3.92 (, 3H), 3.90 (s, 3H), 2.47 (s, 3H).
  • LC-MS (ESI) 460 (M+).
    • 2) Synthesis of 4-{([2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid
  • To methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate (0.116 mmol, 53.4 mg), methanol (2 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.580 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1 hour of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.580 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (37.7 mg, yield 73%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.43 (br.s, 1H), 9.98 (br.s, 1H), 8.07 (ABq, J=8.4 Hz, 2H), 8.01 (ABq, J=8.4 Hz, 2H), 7.89 (ABq, J=8.3 Hz, 2H), 7.84 (ABq, J=8.3 Hz, 2H), 3.92 (s, 3H), 2.47 and 2.42 (sx2, 3H).
  • LC-MS (ESI) 44.6 (M+).
    • Synthetic Example 15 Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid 1) Synthesis of 1-[4-hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (7.49 mmol, 750 mg) and (oxo) [3-trifluoromethylphenyl]acetaldehyde (7.0 mmol, 1.42 g) synthesized in Reference Synthetic Example 8 were dissolved in acetic acid (20 mL) and stirred at 100° C. for 4 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=2/1) and then by silica gel thin layer chromatography (chloroform/methanol=30/1) to give the desired product as a reddish yellow liquid (221 mg, yield 11%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.26 (s, 1H), 7.70-7.60 (multi, 4H), 3.93 (s, 3H), 2.59 (s, 3H).
  • LC-MS (ESI) 284 (M+).
    • 2) Synthesis of methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate
  • 1-[4-Hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.502 mmol, 142.7 mg), 4-hydrazinocarbonylmethyl benzoate (0.502 mmol, 97.5 mg) and p-tosylic acid monohydrate (30 mol %, 26.0 mg) were dissolved in isopropyl alcohol (13 mL) and stirred at 100° C. for about 11 hours. The reactor was cooled to room temperature, and the precipitated solid was recovered by filtration, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) and then by silica gel thin layer chromatography (n-hexane/ethyl acetate=1/2) to give the desired product as a yellow solid (36.7 mg, yield 16%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.46 (br.s, 1H), 9.94 (br.s, 1H), 8.10 (ABq, J=8.1 Hz, 2H), 8.05 (ABq, J=8.1 Hz, 2H), 7.95-7.90 (multi, 2H), 7.81-7.77 (multi, 2H), 3.91 (br.s, 6H), 2.47 (s, 3H).
  • LC-MS (ESI) 460 (M′).
    • 3) Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoic acid
  • To methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}benzoate (0.072 mmol, 33.1 mg), methanol (2 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.360 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (5 eq., 0.360 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (17.6 mg, yield 55%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.40 (br.s, 1H), 9.99 (br.s, 1H), 8.06-7.69 (multi, 8H), 3.91 and 3.89 (br.sx2, 3H), 2.47 and 2.39 (br.sx2, 3H).
  • LC-MS (ESI) 446 (M+).
    • Synthetic Example 16 Synthesis of 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (7.29 mmol, 730 mg) and (3,5-dimethylphenyl)(oxo)acetaldehyde (7.29 mmol, 1.18 g) synthesized in Reference Synthetic Example 10 were dissolved in acetic acid (25 mL) and stirred at 100° C. for 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) and then by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as an orange liquid (93 mg, yield 5%).
  • 1H-NMR (ppm in CDCl3) δ 8.15 (s, 1H), 7.05 (br.s, 3H), 3.88 (s, 3H), 2.58 (s, 3H), 2.37 (s, 6H).
  • LC-MS (ESI) 244 (M+).
    • 2) Synthesis of methyl 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(3,5-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.120 mmol, 29.3 mg) and 4-hydrazinocarbonylmethyl benzoate (0.120 mmol, 23.3 mg) were dissolved in dimethylformamide (5 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (23.4 mg, yield 46%).
  • LC-MS (ESI) 420 (M+).
    • 3) Synthesis of, 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.015 mmol, 6.5 mg), methanol (1 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.077 mL) was added at room temperature. After 20 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.077 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was recovered by filtration and dried to give the desired product as a yellow solid (1.7 mg, yield 27%).
  • LC-MS (MSI) 406 (M+).
    • Synthetic Example 17 Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(4-isopropylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (10.44 mmol, 1.05 g) and (4-isopropylphenyl)(oxo)acetaldehyde (10.44 mmol, 1.84 g) synthesized in Reference Synthetic Example 12 were dissolved in acetic acid (37 mL) and stirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1) and then by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as an orange solid (113 mg, yield 4%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.15 (s, 1H), 7.39 (ABq, J=8.3 Hz, 2H), 7.34 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.96 (sept, J=6.9 Hz, 1H), 2.58 (s, 3H), 1.28 (d, J=6.9 Hz, 6H).
  • LC-MS (ESI) 258 (M+).
    • 2) Synthesis of methyl 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(4-Isopropylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.170 mmol, 44.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.170 mmol, 33.1 mg) were dissolved in dimethylformamide (5.5 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was, recovered by filtration to give the desired product as a yellow solid (39.1 mg, yield 53%).
  • LC-MS (ESI) 434 (M+).
  • 3) Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoate (0.037 mmol, 16.0 mg), methanol (3 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.184 mL) was added at room temperature. After 15 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.184 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (6.8 Mg, yield 44%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.33 (br.s, 1H), 9.70 (br.s, 1H), 8.09-7.93 (multi, 4H), 7.51-7.38 (multi, 4H), 3.86 and 3.84 (sx2, 3H), 2.99-2.94 (multi, 1H), 2.45 and 2.43 (sx2, 3H), 1.26 (d, J=6.9 Hz, 6H).
  • LC-MS (ESI) 420 (M+).
    • Synthetic Example 18 Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (11.60 mmol, 1.16 g) and (4-isobutylphenyl)(oxo)acetaldehyde (11.60 mmol, 2.2.1 g) synthesized in Reference Synthetic Example 15 were dissolved in acetic acid (38 mL) and stirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer, chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a brown solid (154 mg, yield 5%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.17 (s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.26 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.58 (s, 3H), 2.52 (d, J=6.9 Hz, 2H), 1.91 (sept, J=6.9 Hz, 1H), 0.94 (d, J=6.9 Hz, is 6H).
  • LC-MS (ESI) 272 (M+).
    • 2) Synthesis of methyl 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino) carbonyl]benzoate
  • 1-[4-Hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone (0.353 mmol, 96.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.353 mmol, 68.5 mg) were dissolved in dimethylformamide (7 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (93.2 mg, yield 59%).
  • LC-MS (ESI) 448 (M+).
    • 3) Synthesis of 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.129 mmol, 57.7 mg), methanol (2.5 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.643 mL) was added at room temperature. After 15 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.643 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (25.6 mg, yield 46%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.34 (s, 1H), 9.72 (s, 1H), 8.10-7.95 (multi, 4H), 7.50-7.46 (multi, 2H), 7.34-7.30 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.45 (s, 3H), 1.90 (sept, J=6.8 Hz, 1H), 0.91 (d, J=6.8 Hz, 6H).
  • LC-MS (ESI) 434 (M+).
    • Synthetic Example 19 Synthesis of 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-oxopropanal methylhydrazone (10.56 mmol, 1.06 g) and (3-bromo-4-fluorophenyl)(oxo)acetaldehyde (10.56 mmol, 2.44 g) synthesized in Reference Synthetic Example 9 were dissolved in acetic acid (37 mL) and stirred at 100° C. for 4.5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=3/1) to give the desired product as a brown solid (160 mg, yield 5%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.21 (s, 1H), 7.69-7.66 (multi, 1H), 7.41-7.37 (multi, 1H), 7.27-7.22 (multi, 1H), 3.89 (s, 3H), 2.58 (s, 3H).
  • LC-MS (ESI) 312, 314 (M+).
    • 2) Synthesis of methyl 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(3-Bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.269 mmol, 84.1 mg) and 4-hydrazinocarbonylmethyl benzoate (0.269 mmol, 52.2 mg) were dissolved in dimethylformamide (7 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (60.1 mg, yield 461).
  • LC-MS (ESI) 488 (M+).
    • 3) Synthesis of 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.051 mmol, 24.9 mg), methanol (2.5 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.255 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.255 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (9.0 mg, yield 37%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ11.40 (s, 1H), 9.87 (s, 1H), 8.12-7.91 (multi, 5H), 7.62-7.52 (multi, 2H), 3.86 (s, 3H), 2.45 and 2.43 (sx2, 3H).
  • LC-MS (ESI) 474 (M+).
    • Synthetic Example 20 Synthesis of 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (13.7 mmol, 1.37 g) and (4-ethylphenyl)(oxo)acetaldehyde (13.5 mmol, 2.19 g) synthesized in Reference Synthetic Example 11 were dissolved in acetic acid (30 mL) and stirred at 100° C. for 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=7/2) to give the desired product as a brown solid (255 mg, yield 8%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.15 (s, 1H), 7.38 (ABq, J=8.4 Hz, 2H), 7.32 (ABq, J=8.4 Hz, 2H), 3.90 (s, 3H), 2.70 (q, J=7.8 Hz, 2H), 2.58 (s, 3H), 1.28 (t, J=7.8 Hz, 3H).
  • LC-MS (ESI) 244 (M+).
    • 2) Synthesis of methyl 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(4-Ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.459 mmol, 112.1 mg) and 4-hydrazinocarbonylmethyl benzoate (0.459 mmol, 89.1 mg) were dissolved in dimethylformamide (9 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (130.5 mg, yield 68%).
  • LC-MS (ESI) 420 (M+).
    • 3) Synthesis of 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.172 mmol, 72.4 mg), methanol (4 mL) was added, and 1 M aqueous sodium hydroxide (5 eq., 0.861 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.861 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (29.1 mg, yield 42%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.36 (s, 1H), 9.68 (s, 1H), 8.13-7.96 (multi, 4H), 7.50-7.35 (multi, 4H), 3.87 and 3.84 (sx2, 3H), 2.72-2.64 (multi, 2H), 2.45 (s, 3H), 1.26-1.21 (multi, 3H).
  • LC-MS (ESI) 406 (M+).
    • Synthetic Example 21 Synthesis of 4-[((2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(4-n-propylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (19.36 mmol, 1.94 g) and oxo(4-n-propylphenyl)acetaldehyde (19.0 mmol, 3.35 g) synthesized in Reference Synthetic Example 13 were dissolved in acetic acid (42 mL) and stirred at 100° C. for 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=7/2) to give the desired product as a brown solid (304 mg, yield 6%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.15 (s, 1H), 7.37 (ABq, J=8.3 Hz, 2H), 7.29 (ABq, J=8.3 Hz, 2H), 3.90 (s, 3H), 2.64 (t, J=7.5 Hz, 2H), 2.58 (s, 3H), 1.68 (q, J=7.2 Hz, 2H), 0.97 (t, J=7.2 Hz, 3H).
  • LC-MS (ESI) 258 (M+).
    • 2) Synthesis of methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[4-Hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethanone (0.445 mmol, 115.0 mg) and 4-hydrazinocarbonylmethyl benzoate (0.445 mmol, 86.5 mg) were dissolved in dimethylformamide (9 mL) and stirred at is 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (143.3 mg, yield 74%).
  • LC-MS (ESI) 434 (M+).
    • 3) Synthesis of 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino) carbonyl]benzoate (0.166 mmol, 72.2 mg), methanol was added, and 1 M aqueous sodium hydroxide (5 eq., 0.831 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.831 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was recovered by filtration and dried to give the desired product as a yellow solid (47.1 mg, yield 67%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.36 (s, 1H), 9.69 (s, 1H), 8.12-7.96 (multi, 4H), 7.50-7.45 (multi, 2H), 7.39-7.33 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.66-2.59 (multi, 2H), 2.45 (s, 3H), 1.71-1.58 (multi, 2H), 0.96-0.91 (multi, 3H).
  • LC-MS (ESI) 420 (M+).
    • Synthetic Example 22 Synthesis of 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of 1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone
  • 2-Oxopropanal methylhydrazone (16.1 mmol, 1.62 g) and (4-n-hexylphenyl)(oxo)acetaldehyde (16 mmol, 4.57 g) synthesized in Reference Synthetic Example 14 were dissolved in acetic acid (35 mL) and stirred at 100° C. for 6 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/ethyl acetate=3/1), then by silica gel thin layer chromatography (chloroform) and by silica gel thin layer chromatography (n-hexane/ethyl acetate=7/2) to give the desired product as a brown solid (308 mg, yield 6%).
  • 1H-NMR (ppm in CDCl3)
  • δ 8.16 (s, 1H), 7.37 (ABq, J=8.1 Hz, 2H), 7.29 (ABq, J=8.1 Hz, 2H), 3.90 (s, 3H), 2.65 (t, J=7.8 Hz, 2H), 2.58 (s, 3H), 1.64-1.62 (multi, 2H), 1.41-1.28 (multi, 6H), 0.92-0.87 (multi, 3H).
  • LC-MS (ESI) 300 (M+).
    • 2) Synthesis of methyl 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.431 mmol, 129.6 mg) and 4-hydrazinocarbonylmethyl benzoate (0.431 mmol, 83.8 mg) were dissolved in dimethylformamide (8 mL) and stirred at 110° C. for 23 hours. Then, the reactor was cooled to room temperature, and the solvent was evaporated with a centrifugal evaporator. The residue was dried, and chloroform was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (125.1 mg, yield 61%).
  • LC-MS (ESI) 476 (M+).
    • 3) Synthesis of 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.158 mmol, 75.2 mg), methanol was added, and 1 M aqueous sodium hydroxide (5 eq., 0.789 mL) was added at room temperature. After 10 minutes of stirring at room temperature and 2 hours of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (5 eq., 0.789 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump, and the residue was further purified by silica gel thin layer chromatography (chloroform/methanol=10/1). After addition of chloroform/n-hexane, the precipitated solid was dried to give the desired product as a yellow solid (29.4 mg, yield 40%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.36 (s, 1H), 9.69 (s, 1H), 8.13-7.95 (multi, 4H), 7.49-7.45 (multi, 2H), 7.38-7.33 (multi, 2H), 3.87 and 3.84 (sx2, 3H), 2.67-2.61 (multi, 2H), 2.45 (s, 3H), 1.66-1.56 (multi, 2H), 1.36-1.24 (multi, 6H), 0.89-0.85 (multi, 3H).
  • LC-MS (ESI) 462 (M+).
    • Synthetic Example 23 Synthesis of 4-({[2-(1-{(4-hydroxy-1-methyl-5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonothioyl}amino)benzoic acid
  • 1-[4-Hydroxy-1-methyl-5-(3-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.229 mmol, 65.0 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.229 mmol, 48.3 mg) were stirred with dimethylformamide (2.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 24 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. Chloroform/n-hexane was added to the resulting solid, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (74.7 mg, yield 68%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.36 and 10.33 (br.sx2, 1H), 9.12 (s, 1H), 7.95-7.77 (multi, 8H), 3.86 (s, 3H), 2.41 (s, 3H).
  • LC-MS (ESI) 477 (M+).
    • Synthetic Example 24 Synthesis of 4-{[(2-{1-[5-(3,5-dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(3,5-Dimethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.122 mmol, 29.9 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.122 mmol, 25.9 mg) were stirred with dimethylformamide (2 mL) and two drops of concentrated hydrochloric acid at room temperature for 24 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (34.7 mg, yield 65%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.87 (br.s, 1H), 10.33 and 10.32 (br.sx2, 1H), 8.84 (s, 1H), 7.93 (ABq, J=8.1 Hz, 2H), 7.84 (ABq, J=8.1 Hz, 2H), 7.16-7.14 (multi, 2H), 7.06 (br.s, 1H), 3.81 and 3.79 (sx2, 3H), 2.46 and 2.39 (sx2, 3H), 2.35-2.31 (multi, 6H).
  • LC-MS (ESI) 437 (M+).
    • Synthetic Example 25 Synthesis of 4-{[(2-{1-[4-hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[4-Hydroxy-5-(4-isopropylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone (0.116 mmol, 29.9 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.116 mmol, 24.5 mg) were stirred with dimethylformamide (2 mL) and two drops of concentrated hydrochloric acid at room temperature for 24 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (37.7 mg, yield 72%)
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.90 (br.s, 1H), 10.35 and 10.33 (br.sx2, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.85 (ABq, J=8.6 Hz, 2H), 7.47 (ABq, J=8.1 Hz, 2H), 7.39 (ABq, J=8.1 Hz, 2H), 3.83 and 3.81 (sx2, 3H), 2.95 (sept, J=6.9 Hz, 1H), 2.46 and 2.39 (sx2, 3H), 1.27-1.24 (multi, 6H).
  • LC-MS (ESI) 451 (M+).
    • Synthetic Example 26 Synthesis of 4-{[(2-{1-[4-hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[4-Hydroxy-5-(4-isobutylphenyl)-1-methyl-1H-pyrazol-3-yl]ethanone (0.179 mmol, 48.8 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.179 mmol, 37.9 mg) were stirred with dimethylformamide (2.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 24.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (62.6 mg, yield 75%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.87 (br.s, 1H), 10.34 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.85 (ABq, J=8.6 Hz, 2H), 7.46 (ABq, J=8.3 Hz, 2H), 7.30 (ABq, J=8.3 Hz, 2H), 3.83 and 3.81 (sx2, 3H), 2.54-2.51 (multi, 2H), 2.46 and 2.39 (sx2, 3H), 1.89 (sept, J=6.8 Hz, 1H), 0.92-0.89 (multi, 6H).
  • LC-MS (ESI) 465 (M+).
    • Synthetic Example 27 Synthesis of 4-{[(2-{1-[5-(3-bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(3-Bromo-4-fluorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.139 mmol, 43.6 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.139 mmol, 29.4 mg) were stirred with dimethylformamide (2.5 mL) and three drops of concentrated hydrochloric acid at room temperature for 24.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a yellow solid (51.8 mg, yield 74%).
  • 1H-NMR (ppm in DMSO-d6) δ 10.35 and 10.32 (br.sx2, 1H), 9.08 (s, 1H), 7.98-7.79 (multi, 5H), 7.65-7.51 (multi, 2H), 3.83 (s, 3H), 2.46 and 2.39 (sx2, 3H).
  • LC-MS (ESI) 505, 507 (M+).
    • Synthetic Example 28 Synthesis of 4-{[(2-{1-[5-(4-ethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[5-(4-Ethylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.159 mmol, 38.8 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.159 mmol, 33.6 mg) were stirred with dimethylformamide (2.3 mL) and three drops of concentrated hydrochloric acid at room temperature for 23.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (50.6 mg, yield 73%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.87 (br.s, 1H), 10.33 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.7 Hz, 2H), 7.85 (ABq, J=8.7 Hz, 2H), 7.46 (ABq, J=8.1 Hz, 2H), 7.36 (ABq, J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.67 (q, J=7.5 Hz, 2H), 2.46 and 2.39 (sx2, 3H), 1.26-1.20 (multi, 3H).
  • LC-MS (ESI) 437 (M+).
    • Synthetic Example 29 Synthesis of 4-{[(2-{1-[4-hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 1-[4-Hydroxy-1-methyl-5-(4-n-propylphenyl)-1H-pyrazol-3-yl]ethanone (0.157 mmol, 40.5 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.157 mmol, 33.1 mg) were stirred with dimethylformamide (2.3 mL) and three drops of concentrated hydrochloric acid at room temperature for 23.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (56.2 mg, yield 79%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 10.32 (br.s, 1H), 8.85 (s, 1H), 7.93 (ABq, J=8.7 Hz, 2H), 7.85 (ABq, J=8.7 Hz, 2H), 7.46 (ABq, J=8.1 Hz, 2H), 7.34 (ABq, J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.62 (t, J=7.7 Hz, 2H), 2.46 and 2.39 (sx2, 3H), 1.70-1.57 (multi, 2H), 0.97-0.91 (multi, 3H).
  • LC-MS (ESI) 451 (M+).
    • Synthetic Example 30 Synthesis of 4-{[(2-{1-[5-(4-n-hexylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
  • 1-[5-(4-n-Hexylphenyl)-1-methyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.117 mmol, 35.1 mg) and 4-hydrazinocarbonothioylaminobenzoic acid (0.117 mmol, 24.7 mg) were stirred with dimethylformamide (2.3 mL) and three drops of concentrated hydrochloric acid at room temperature for 23.5 hours. After addition of water, the precipitated yellow solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting solid was stirred with chloroform/n-hexane for a while, then recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (46.3 mg, yield 80%).
  • 1H-NMR (ppm, in DMSO-d6)
  • δ 10.87 (br.s, 1H), 10.33 (br.s, 1H), 8.84 (s, 1H), 7.93 (ABq, J=8.6 Hz, 2H), 7.84 (AEg, J=8.6 Hz, 2H), 7.45 (ABq, J=8.1 Hz, 2H), 7.33 (ABq, J=8.1 Hz, 2H), 3.82 and 3.80 (sx2, 3H), 2.63 (t, J=7.7 Hz, 2H), 2.46 and 2.39 (sx2, 3H), 1.61 (multi, 2H), 1.30 (multi, 6H), 0.86 (multi, 3H).
  • LC-MS (ESI) 493 (M+).
    • Synthetic Example 31 Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonyl]benzoic acid 1) Synthesis of methyl 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(4-t-Butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.313 mmol, 89.5 mg), 4-hydrazinocarbonylmethyl benzoate (0.313 mmol, 60.7 mg) and p-tosylic acid monohydrate (30 mol %, 16.1 mg) were dissolved in isopropyl alcohol (16 mL) and stirred at 100° C. for 19 hours. The reactor was cooled to room temperature, and the solvent was evaporated. The resulting crude product was purified by silica gel column chromatography (chloroform/methanol=10/1) and then by silica gel column chromatography (n-hexane/ethyl acetate=1/2) to give the desired product as a yellow solid (16.8 mg, yield 12%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.39 (br.s, 1H), 9.60 (br.s, 1H), 8.10 (ABq, J=8.3 Hz, 2H), 8.04 (ABq, J=8.3 Hz, 2H), 7.55 (ABq, J=8.1 Hz, 2H), 7.44 (ABq, J=8.1 Hz, 2H), 4.12 (q, J=7.2 Hz, 2H), 3.90 (s, 3H), 2.46 (s, 3H), 1.34 (s, 9H), 1.29 (t, J=7.2 Hz, 3H).
  • LC-MS (ESI) 462 (M+).
    • 2) Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[5-(4-t-butylphenyl)-1-ethyl-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.032 mmol, 15.0 mg), methanol (1.5 mL) was added, and 1 M aqueous sodium hydroxide (0.162 mmol, 0.162 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.25 hours of stirring at 60° C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (0.162 mmol, 0.162 mL) and water were added. The precipitated solid was recovered by filtration, washed with water, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (6.4 mg, yield 44%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.33 (br.s, 1H), 9.64 (br.s, 1H), 8.06-7.94 (multi, 4H), 7.58-7.43 (multi, 4H), 4.12 (q, J=7.5 Hz, 2H), 2.46 and 2.44 (sx2, 3H), 1.34 (s, 9H), 1.27 (t, J=7.5 Hz, 3H).
  • LC-MS (ESI) 448 (M+).
    • Synthetic Example 32 Synthesis of 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of methyl 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[1-Benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethanone (0.610 mmol, 212.6 mg), 4-hydrazinocarbonylmethyl benzoate (0.610 mmol, 118.5 mg) and p-tosylic acid monohydrate (30 mol %, 31.5 mg) were dissolved in isopropyl alcohol (20 mL) and stirred at 100° C. for 18 hours. The reactor was cooled to room temperature, and the solvent was evaporated. The resulting crude product was purified by silica gel column chromatography (chloroform/methanol=10/1) and then by silica gel column chromatography (n-hexane/ethyl acetate=1/2) to give the desired product as a yellow solid (56.6 mg, yield 18%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.44 (br.s, 1H), 9.72 (br.s, 1H), 8.11 (ABq, J=8.1 Hz, 2H), 8.05 (ABq, J=8.1 Hz, 2H), 7.49 (ABq, J=8.3 Hz, 2H), 7.37 (ABq, J=8.3 Hz, 2H), 7.32-7.22 (multi, 3H), 6.99-6.97 (multi, 2H), 5.38 (s, 2H), 3.91 (s, 3H), 2.46 (s, 3H), 1.30 (s, 9H).
  • LC-MS (ESI) 524 (M+).
    • 2) Synthesis of 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 4-[(2-{1-[1-benzyl-5-(4-t-butylphenyl)-4-hydroxy-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.045 mmol, 23.5 mg), methanol was added, and 1 M aqueous sodium hydroxide (0.224 mmol, 0.224 mL) was added at room temperature. After 30 minutes of stirring at room temperature and 1.5 hours of stirring at 60° C., the reactor was cooled to 0° C., and 1 M hydrochloric acid (0.224 mmol, 0.224 mL) and water were added. The precipitated solid was recovered by filtration, washed with water, dried by means of a vacuum pump and purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (15.8 mg, yield 69%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.41 (br.s, 1H), 9.74 (br.s, 1H), 8.06-6.97 (multi, 13H), 5.38 (s, 2H), 2.46 (s, 3H), 1.30 (s, 9H).
  • LC-MS (ESI) 510 (M+).
    • Synthetic Example 33 Synthesis of methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
  • 1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (38.0 mg, 0.14 mmol) and methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (27.9 mg, 0.14 mmol) were dissolved in dimethylformamide (2.0 mL) and stirred at 110° C. for 12 hours. After cooling, the solvent was evaporated, and ethyl acetate was added to the resulting crude product. The precipitated solid was recovered by filtration to give 20.0 mg of the desired product as a pale yellow solid (yield 31%).
  • 1H-NMR (ppm in CDCl3)
  • δ 7.78 (d, J=3.6 Hz, 1H), 7.42-7.52 (multi, 5H), 3.92 (s, 3H), 3.88 (s, 3H), 2.45 (s, 3H), 1.36 (s, 9H).
  • LC-MS (ESI) 454 (M+).
    • Synthetic Example 34 Synthesis of 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
  • Methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (16.0 mg, 0.035 mmol) in methanol (1.5 mL) was stirred with 1 M aqueous sodium hydroxide (176 μL, 0.176 mmol) at room temperature for 17 hours. After the stirring, 1 M hydrochloric acid (176 μL, 0.176 mmol) was added, and the precipitated solid was recovered by filtration to give 6.2 mg of the desired product as yellow crystals (yield 40%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.36 (br.s, 1H), 9.50 (br.s, 1H), 8.02 (d, J=4.5 Hz, 1H), 7.79 (d, J=4.5 Hz, 1H), 7.48-7.56 (multi, 4H), 3.84 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H).
  • LC-MS (ESI) 440 (M+).
    • Synthetic Example 35 Synthesis of methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • 2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.36 mmol) synthesized in Reference Synthetic Example 33 and 4-hydrazinocarbonylmethyl benzoate (70 mg, 0.36 mmol) were stirred in dimethylformamide (3.6 mL) at 120° C. overnight. The reaction solution was partitioned between ethyl acetate-saturated aqueous ammonium chloride, and the organic layer was washed with saturated aqueous sodium chloride. The precipitated solid was recovered from the solution by filtration to give the desired product as a pale yellow solid (58 mg, yield 36%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.2 Hz, 2H), 7.71 (d, J=8.2 Hz, 2H), 7.99-8.13 (m, 5H), 11.48 (s, 1H), 12.23 (s, 1H).
  • 1H-NMR (ppm in MeOH-d4) δ 1.34 (s, 9H), 2.48 (s, 3H), 3.95 (s, 3H), 7.39-8.16 (m, 9H).
  • LC/MS (ES+) 451.
    • Synthetic Example 36 Synthesis of methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • 2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 34 and 4-hydrazinocarbonylmethyl benzoate (68 mg, 0.35 mmol) were stirred in dimethylformamide (3.6 mL) at 120° C. under heating overnight. The resulting reaction solution was concentrated, and ethyl acetate/n-hexane was added. The precipitated solid was recovered by filtration to give the desired product as a pale yellow solid (141 mg, yield 87%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.91 (s, 3H), 7.64-7.73 (m, 2H), 8.05-8.13 (m, 6H), 11.55 (bs, 1H).
  • LC/MS (ES−) 461, 462, 464.
    • Synthetic Example 37 Synthesis of methyl 4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 35, the desired product was obtained in the same manner as in Synthetic Example 36 as a pale yellow solid (132 mg, yield 82%).
  • 1H-NMR (ppm in MeOH— d4)
  • δ 2.49 (s, 3H), 3.95 (s, 3H), 7.64-7.67 (m, 2H), 7.88 (s, 1H), 8.03-8.04 (m, 4H), 8.15-8.18 (m, 2H).
  • LC/MS (ES+) 463.
    • Synthetic Example 38 Synthesis of methyl 2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}-hydrazino)carbonyl]benzoate
  • 2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (80 mg, 0.29 mmol) and methyl 2-nitro-4-hyrazinocarbonylbenzoate (69 mg, 0.29 mmol) were stirred in dimethylformamide (2.9 mL) at 120° C. under heating overnight. The resulting reaction solution was concentrated, and ethyl acetate/n-hexane was added. The precipitated solid was recovered by filtration to give the desired product as a brown solid (92 mg, yield 64%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 3.90 (s, 3H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H), 8.02-8.07 (m, 2H), 8.36 (d, J=7.4 Hz, 1H), 8.59 (s, 1H).
  • LC/MS (ES+) 496.
    • Synthetic Example 39 Synthesis of methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
  • 2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (80 mg, 0.29 mmol) and methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (58 mg, 0.29 mmol) were stirred in dimethylformamide (2.9 mL) at 120° C. under heating overnight. The resulting reaction solution was concentrated, and chloroform/n-hexane was added. The precipitated solid was recovered by filtration to give the desired product as a yellow solid (79 mg, yield 60%).
  • 1H-NMR (ppm in MeOH-d4)
  • δ 1.34 (s, 9H), 2.48 (s, 3H), 3.91 (s, 3H), 7.38-7.81 (m, 7H).
  • LC/MS (ES+) 457.
    • Synthetic Example 40 Synthesis of methyl 4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate
  • 2-(4-t-Butylphenyl)-3-hydroxy-4-formylthiophene (100 mg, 0.38 mmol) synthesized in Reference Synthetic Example 25 and 4-hydrazinocarbonylmethyl benzoate (74 mg, 0.38 mmol) were stirred in dimethylformamide (3.8 mL) at room temperature overnight. The reaction solution was partitioned between ethyl acetate-water, and the organic layer was washed with saturated aqueous sodium chloride. The resulting organic layer was concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a light brown solid (74 mg, yield 46%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 3.91 (s, 3H), 7.44 (d, J=8.4 Hz, 2H), 7.69 (d, J=8.4 Hz, 2H), 7.93-7.95 (m, 2H), 8.06-8.15 (m, 4H), 8.57 (s, 1H), 10.87 (s, 1H), 12.40 (s, 1H).
  • LC/MS (ES+) 437.
    • Synthetic Example 41 Synthesis of methyl 4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate
  • 2-(3,4-Dichlorophenyl)-3-hydroxy-4-formylthiophene (104 mg, 0.38 mmol) synthesized in Reference Synthetic Example 26 and 4-hydrazinocarbonylmethyl benzoate (74 mg, is 0.38 mmol) were stirred in dimethylformamide (3.8 mL) at room temperature overnight. Water was added to the reaction solution, and the precipitated solid was recovered by filtration to give the desired product as a pale yellow solid (175 mg, yield 100%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.91 (s, 3H), 7.65-7.72 (m, 2H), 7.96-8.14 (m, 7H), 8.62 (s, 1H), 11.37 (bs, 1H).
  • LC/MS (ES+) 451, 452, 453.
    • Synthetic Example 42
  • Synthesis, of 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • Methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (50 mg, 0.11 mmol) synthesized in Synthetic Example 35 was dissolved in methanol (1.1 mL) and stirred with 1 M aqueous sodium hydroxide (0.55 mL, 0.55 mmol) at 45° C. for 1.5 hours. After the stirring, 1 M hydrochloric acid (0.55 mL, 0.55 mmol) was added, and the precipitated pale yellow solid was recovered by filtration. The resulting solid was purified by silica gel chromatography (chloroform:methanol=9:1). The resulting solid was stirred with chloroform at room temperature and recovered by filtration to give the desired product as a pale yellow solid (11 mg, yield 23%).
  • 1H-NMR (ppm in MeOH-d4)
  • δ 1.34 (s, 9H), 2.48 (s, 3H), 7.39-8.08 (m, 9H).
  • LC/MS (ES+) 437.
    • Synthetic Example 43 Synthesis of 4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoic acid
  • From methyl 4-[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate (62 mg, 0.14 mmol) synthesized in Synthetic Example 40, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (34 mg, yield 57%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 7.44 (d, J=8.4 Hz, 2H), 7.69 (d, J=8.4 Hz, 2H), 7.93 (s, 1H), 8.03-8.09 (m, 4H), 8.58 (s, 1H), 10.88 (s, 1H), 12.38 (bs, 1H).
  • LC/MS (ES+) 423.
    • Synthetic Example 44 Synthesis of 4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoic acid
  • From methyl 4-[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonyl]benzoate (120 mg, 0.27 mmol) synthesized in Synthetic Example 41, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (44 mg, yield 37%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.66-7.72 (m, 2H), 8.03-8.21 (m, 6H), 8.58 (s, 1H), 11.37 (bs, 1H).
    • Synthetic Example 45 Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • From methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (100 mg, 0.22 mmol) synthesized in Synthetic Example 36, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (9 mg, yield 9%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.64-7.73 (m, 2H), 8.01-8.12 (m, 6H).
  • 1H-NMR (ppm in MeOH-d4)
  • δ 2.47 (s, 3H), 7.47-8.16 (m, 8H).
  • LC/MS (ES+) 449, 450, 451.
    • Synthetic Example 46 Synthesis of 4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • From methyl 4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (100 mg, 0.22 mmol) synthesized in Synthetic Example 37, the desired product was obtained in the same manner as in Synthetic Example 42 as a colorless solid (34 mg, yield 34%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.75-7.78 (m, 2H), 8.00-8.15 (m, 7H), 11.51 (bs, 1H).
  • LC/MS (ES−) 447.
    • Synthetic Example 47 Synthesis of 2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • From methyl 2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (60 mg, 0.12 mmol) synthesized in Synthetic Example 38, the desired product was obtained in the same manner as in Synthetic Example 42 as a yellow solid (10 mg, yield 17%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H), 7.95-8.03 (m, 2H), 8.30 (d, J=8.0 Hz, 1H), 8.51 (s, 1H).
  • 1H-NMR (ppm in MeOH-d4)
  • δ 1.34 (s, 9H), 2.49 (s, 3H), 7.39-8.46 (m, 8H).
  • LC/MS (ES+) 482.
    • Synthetic Example 48 Synthesis of 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
  • From methyl 5-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (72 mg, 0.16 mmol) synthesized in Synthetic Example 39, the desired product was obtained in the same manner as in Synthetic Example 42 as a yellow solid (12 mg, yield 17%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 7.43 (d, J=8.5 Hz, 2H), 7.70 (d, J=8.5 Hz, 2H), 7.81 (d, J=4.1 Hz, 1H), 8.00 (s, 1H), 8.04 (d, J=4.1 Hz, 1H).
  • LC/MS (ES−) 442.
    • Synthetic Example 49 Synthesis of 4-{[(2-{[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonothioyl]amino}benzoic acid
  • 2-(4-t-Butylphenyl)-3-hydroxy-4-formylthiophene (50 mg, 0.19 mmol) synthesized in Reference Synthetic Example 25 and 4-hydrazinocarbonothioylaminobenzoic acid (40 mg, 0.19 mmol) were stirred with dimethylformamide (1.9 mL) and concentrated hydrochloric acid (0.1 mL) at room temperature for 12 hours. The reaction solution was partitioned between ethyl acetate and water, and the organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The resulting organic layer was concentrated and purified by silica gel column chromatography (chloroform).
  • Methanol/chloroform was added to the resulting crude product, and the precipitated yellow solid was recovered by filtration to give the desired product as a pale yellow solid (20 mg, yield 23%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ1.30 (s, 9H), 7.43 (d, J=8.5 Hz, 2H), 7.67 (d, J=8.5 Hz, 2H), 7.79 (d, J=8.5 Hz, 2H), 7.93-7.99 (m, 3H), 8.24 (s, 1H), 10.32 (s, 1H), 11.93 (s, 1H).
  • LC/MS (ES+) 454.
    • Synthetic Example 50 Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}benzoic acid
  • 2-(4-t-Butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (31 mg, 0.11 mmol) synthesized in Reference Synthetic Example 33 and 4-hydrazinocarbonothioylaminobenzoic acid (23 mg, 0.11 mmol) were stirred with dimethylformamide (1.1 mL) and concentrated hydrochloric acid (0.05 mL) at room temperature for 30 hours. The reaction solution was partitioned between ethyl acetate and water, and the organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The resulting organic layer was concentrated and purified by silica gel column chromatography (chloroform) to give the desired product as a light brown solid (27 mg, yield 52%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 2.39 (s, 3H), 7.43 (d, J=8.5 Hz, 2H), 7.69 (d, J=8.5 Hz, 2H), 7.86-7.95 (m, 5H), 10.40 (s, 1H), 11.08 (s, 1H).
  • LC/MS (ES+) 468.
    • Synthetic Example 51 Synthesis of 4-{[(2-{[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]methylene}hydrazino)carbonothioyl]amino}benzoic acid
  • 2-(3,4-Dichlorophenyl)-3-hydroxy-4-formylthiophene (52 mg, 0.19 mmol) synthesized in Reference Synthetic Example 26 and 4-hydrazinocarbonothioylaminobenzoic acid (40 mg, 0.19 mmol) were stirred with dimethylformamide (1.9 mL) and concentrated hydrochloric acid (0.1 mL) at room temperature for 14 hours. Water was added to the reaction solution, and the precipitated solid was recovered by filtration and dried. The crude product was stirred with chloroform at room temperature and recovered by filtration to give the desired product as a pale yellow solid (58 mg, yield 65%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.67-8.10 (m, 8H), 8.25 (s, 1H), 10.34 (s, 1H), 11.95 (s, 1H).
  • LC/MS (ES+) 465, 467, 469.
    • Synthetic Example 52 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethyliden}hydrazino)carbonothioyl]amino}benzoic acid
  • From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) synthesized in Reference Synthetic Example 34, the desired product was obtained in the same manner as in Synthetic Example 51 as a pale yellow solid (23 mg, yield 28%).
  • LC/MS (ES+) 480, 481, 482, 484.
    • Synthetic Example 53 Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethyliden}hydrazino)carbonothioyl]-amino}benzoic acid
  • From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) synthesized in Reference Synthetic Example 35, the desired product was obtained in the same manner as in Synthetic Example 51 as a pale yellow solid (48 mg, 59%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 2.41 (s, 3H), 7.74-8.11 (m, 9H), 10.49 (s, 1H), 11.18 (s, 1H).
  • LC/MS (ES+) 480.
    • Synthetic Example 54 Synthesis of 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoic acid 1) Synthesis of [5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone
  • Oxo(phenyl)acetaldehyde methylhydrazone (5.46 mmol, 886 mg) synthesized in Reference Synthetic Example 36 and (4-t-butylphenyl)(oxo)acetaldehyde (5 mmol, 951 mg) were dissolved in acetic acid (26 mL) and stirred at 100° C. for about 2 hours. Then, the solvent was evaporated, and the residue was recrystallized from chloroform/n-hexane to give the desired product as a yellow solid (993 mg, yield 59%).
  • 1H-NMR (ppm in CDCl3)
  • δ 9.04 (s, 1H), 8.51-8.48 (multi, 2H), 7.61-7.59 (multi, 1H), 7.55-7.44 (multi, 6H), 3.98 (s, 3H), 1.37 (s, 9H).
  • LC-MS (ESI) 334 (M+).
    • 2) Synthesis of methyl 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoate
  • [5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone (0.299 mmol, 99.9 mg), 4-hydrazinocarbonylmethyl benzoate (0.299 mmol, 58.0 mg) and p-tosylic acid monohydrate (30 mold, 15.4 mg) were dissolved in isopropyl alcohol (12 mL) and stirred at 100° C. for about 24 hours. Then, the reactor was cooled to room temperature, and the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (119 mg, yield 78%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.29 (s, 1H), 9.85 (s, 1H), 8.03 (ABq, J=8.3 Hz, 2H), 7.84 (ABq, J=8.3 Hz, 2H), 7.62-7.55 (multi, 9H), 3.90 and 3.87 (sx2, 3H), 3.77 and 3.73 (sx2, 3H), 1.34 and 1.32 (sx2, 9H).
  • LC-MS (ESI) 510 (M+).
    • 3) Synthesis of 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoic acid
  • To methyl 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)benzoate (0.196 mmol, 100 mg), methanol (4 mL) was added, and 1 M aqueous sodium hydroxide (0.981 mmol, 0.981 mL) was added at room temperature. After 15 minutes of stirring at room temperature and 1 hour of stirring at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (0.981 mmol, 0.981 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a yellow solid (93 mg, yield 95%).
  • 1H-NMR (ppm in DMSO-d6) δ 11.25 (s, 1H), 9.86 (s, 1H), 8.00 (ABq, Hz, 2H), 7.81 (ABq, J=8.3 Hz, 2H), 7.62-7.55 (multi, 9H), 3.77 and 3.73 (sx2, 3H), 1.34 and 1.32 (sx2, 9H).
  • LC-MS (ESI) 496 (M+).
    • Synthetic Example 55 Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene]hydrazino}carbonyl)-N-methylbenzenesulfonamide
  • 1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.228 mmol, 62 mg), 4-(hydrazinocarbonyl)-N-methylbenzenesulfonamide (0.228 mmol, 52 mg) and p-tosylic acid monohydrate (30 mol&, 11.8 mg) were dissolved in isopropyl alcohol (6 mL) and stirred at 100° C. for 19 hours. Then, the solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (30.3 mg, is yield 28%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.40 (s, 1H), 9.65 (s, 1H), 8.32 (s, 1H), 8.10 (ABq, J=8.4 Hz, 2H), 7.91 (ABq, J=8.4 Hz, 2H), 7.57-7.49 (multi, 4H), 3.89 and 3.85 (sx2, 3H), 2.46 (s, 3H), 2.45 (s, 3H), 1.34 (s, 9H).
  • LC-MS (ESI) 483 (M+).
    • Synthetic Example 56 Synthesis of 4-({2-[[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methylene]hydrazino}carbonyl)-N-methylbenzenesulfonamide
  • [5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl](phenyl)methanone (0.254 mmol, 85 mg), 4-(hydrazinocarbonyl)-N-methylbenzenesulfonamide (0.254 mmol, 58 mg) and p-tosylic acid monohydrate (30 mol %, 13 mg) were dissolved in isopropyl alcohol (8.5 mL) and stirred at 100° C. for 19 hours. Then, the solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform/methanol=10/1) to give the desired product as a yellow solid (30.3 mg, yield 22%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.69 and 11.32 (sx2, 1H), 9.84 and 8.64 (sx2, 1H), 8.64 (s, 1H), 8.09-7.82 (multi, 4H), 7.69-7.44 (multi, 9H), 3.91-3.73 (multi, 3H), 2.47 and 2.38 (multi, 3H), 1.34-1.33 (sx2, 9H).
  • LC-MS (ESI) 545 (M+).
    • Synthetic Example 57 Synthesis of N′-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}-4-(1H-tetrazol-5-yl)benzhydrazide
  • 1-[5-(4-t-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.404 mmol, 110 mg) and 4-(1-H-tetrazol-5-yl)benzhydrazide (0.404 mmol, 83 mg) synthesized in accordance with WO03/037328 were dissolved in dimethylformamide (5 mL) and stirred at 100° C. for 26 hours. The insolubles were filtered off and washed with methanol, and the filtrate was concentrated and separated by silica gel thin layer chromatography (chloroform/MeOH=4/1) to give the desired product as a yellow solid (25 mg, yield 13%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.22 (s, 1H), 9.76 (s, 1H), 8.13 (ABq, J=8.3 Hz, 2H), 7.99 (ABq, J=8.3 Hz, 2H), 7.57-7.50 (multi, 4H), 3.91 and 3.85 (sx2, 3H), 2.46 and 2.42 (sx2, 3H), 1.34 (s, 9H).
  • LC-MS (ESI) 458 (M+).
    • Synthetic Example 58 Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid 1) Synthesis of methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate
  • 1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (1.149 mmol, 312.9 mg) synthesized in Synthetic Example 3, methyl 2-nitro-4-hydrazinocarbonylbenzoate (1.149 mmol, 274.8 mg) synthesized in Reference Synthetic Example 40 and p-tosylic acid monohydride (30 mol %, 59.4 mg) were dissolved in isopropyl alcohol (30 mL) and stirred under heating with reflux for 6 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a yellow solid (470 mg, yield 83%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.54 (s, 1H), 9.57 (s, 1H), 8.57 (s, 1H), 8.33 (d, J=8.0 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.90 (s, 3H), 3.85 (s, 3H), 2.46 (s, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 493 (M+)
    • 2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid
  • To methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate (0.945 mmol, 466.2 mg), methanol (33 mL) was added, and 1 M aqueous sodium hydroxide (4.7 mmol, 4.7 mL) was added. After about 26 hours of stirring at room temperature and 3 hours of stirring at 40° C., 1 M hydrochloric acid (4.7 mmol, 4.7 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump. The resulting yellow solid (359.5 mg) was dissolved in THF (50 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (260.7 mg, yield 58%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.50 (s, 1H), 9.58 (s, 1H), 8.47 (s, 1H), 8.27 (d, J=8.1 Hz, 1H), 7.99 (d, J=8.1 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.85 (s, 3H), 2.46 (s, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 479 (M+)
    • Synthetic Example 59 Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoic acid 1) Synthesis of methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoate
  • 1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.568 mmol, 154.8 mg) synthesized in Synthetic Example 3, methyl 2-chloro-4-hydrazinocarbonylbenzoate (0.568 mmol, 130.0 mg) synthesized in Reference Synthetic Example 41 and p-tosylic acid monohydride (30 mold, 29.4 mg) were dissolved in isopropyl alcohol (15 mL) and stirred under heating with reflux for 8 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (233.7 mg, yield 85%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.42 (s, 1H), 9.61 (s, 1H), 8.10 (s, 1H), 7.95 (s, 2H), 7.55 (ABq, J=8.6 Hz, 2H), 7.50 (ABq, J=8.6 Hz, 2H), 3.91 (s, 3H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 482 (M+)
    • 2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoic acid
  • To methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-chlorobenzoate (0.465 mmol, 224.8 mg), methanol (20 mL) was added, and 1 M aqueous sodium hydroxide (2.3 mmol, 2.3 mL) was added. After 5 hours of stirring at 50° C., 14 hours of stirring at room temperature and 4 hours of stirring at 50° C., 1 M hydrochloric acid (2.3 mmol, 2.3 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the crude desired product as a yellow solid (193.3 mg). Further, 169 mg of the crude desired product was dissolved in THF (35 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (142.3 mg, yield 75%).
  • 1H-NMR (ppm in DMSO-d6) δ 11.40 (s, 1H), 9.63 (s, 1H), 8.06 (s, 1H), 7.93 (d, J=8.1 Hz, 1H), 7.89 (d, J=8.1 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 468 (M+)
    • Synthetic Example 60 Synthesis of 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid 1) Synthesis of methyl 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate
  • 1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.554 mmol, 150.9 mg) synthesized in Synthetic Example 3, methyl 2-bromo-4-hydrazinocarbonylbenzoate (0.554 mmol, 150.8 mg) synthesized in Reference Synthetic Example 42 and p-tosylic acid monohydride (30 mol %, 28.6 mg) were dissolved in isopropyl alcohol (15 mL) and stirred under heating with reflux for 8 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (252.3 mg, yield 86%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.42 (s, 1H), 9.61 (s, 1H), 8.25 (d, J=2.7 Hz, 1H), 8.00 (dd, J=2.7, 8.2 Hz, 1H), 7.89 (d, J=8.2 Hz, 1H), 7.55 (ABq, J=8.4 Hz, 2H), 7.50 (ABq, J=8.4 Hz, 2H), 3.90 (s, 3H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 526 and 528 (M+)
    • 2) Synthesis of 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To methyl 2-bromo-4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoate (0.455 mmol, 239.8 mg), methanol (20 mL) was added, and 1 M aqueous sodium hydroxide (2.3 mmol, 2.3 mL) was added. After 0.5 hours of stirring at 50° C., 14 hours of stirring at room temperature and 4 hours of stirring at 50° C., 1 M hydrochloric acid (2.3 mmol, 2.3 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the crude desired product as a yellow solid (203.8 mg). Further, 178 mg of the crude desired product was dissolved in THF (35 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of vacuum pump to give the desired product as a pale yellow solid (150.9 mg, yield 74%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.39 (s, 1H), 9.63 (s, 1H), 8.21 (s, 1H), 7.96 (d, J=8.0 Hz, 1H), 7.83 (d, J=8.0 Hz, 1H), 7.55 (ABq, J=8.7 Hz, 2H), 7.50 (ABq, J=8.7 Hz, 2H), 3.85 (s, 3H), 2.45 (s, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 512 and 514 (M+)
    • Synthetic Example 61 Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoic acid 1) Synthesis of methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoate
  • 1-[5-(4-tert-Butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.578 mmol, 157.5 mg) synthesized in Synthetic Example 3, methyl 4-hydrazinocarbonyl-2-hydroxybenzoate (0.578 mmol, 121.6 mg) synthesized in Reference Synthetic Example 43 and p-tosylic acid monohydride (30 mol %, 30 mg) were dissolved in isopropyl alcohol (15 mL) and stirred under heating with reflux for 8 hours, and the reactor was cooled to 0° C. The reaction solution was filtered and dried by means of a vacuum pump to give the desired product as a white solid (216.6 mg, yield 81%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.33 (s, 1H), 10.61 (s, 1H), 9.65 (s, 1H), 7.89 (d, J=8.1 Hz, 1H), 7.56-7.43 (multi, 6H), 3.92 (s, 3H), 3.85 (s, 3H), 2.45 and 2.44 (sx2, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 464 (M+)
    • 2) Synthesis of 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoic acid
  • To methyl 4-[(2-{1-[5-(4-tert-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-hydroxybenzoate (0.438 mmol, 203.3 mg), methanol (20 mL) was added, and 1 M aqueous sodium hydroxide (2.2 mmol, 2.2 mL) was added. After 5 hours of stirring at 50° C., 14 hours of stirring at room temperature and 4 hours of stirring at 50° C., 1 M hydrochloric acid (2.2 mmol, 2.2 mL) and water were added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the crude desired product as a yellow solid (175.0 mg). It was further dissolved in THF (35 mL) and stirred at room temperature for 2 days. The insolubles were filtered off, and the filtrate was concentrated and dried by means of a vacuum pump. After addition of chloroform, the precipitated solid was recovered by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (151.6 mg, yield 77%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.30 (s, 1H), 10.61 (s, 1H), 9.66 (s, 1H), 7.90 (d, J=8.1 Hz, 1H), 7.56-7.38 (multi, 6H), 3.85 (s, 3H), 2.44 (s, 3H), 1.33 (s, 9H)
  • LC-MS (ESI) 450 (M+)
    • Synthetic Example 62 Synthesis of methyl 4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) synthesized in Reference Synthetic Example 49, the desired product was obtained in the same manner as in Synthetic Example 36 as a light brown solid (143 mg, yield 91%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.91 (s, 3H), 7.57-7.66 (m, 2H), 7.97-8.20 (m, 7H).
  • LC/MS (ES+) 463.
    • Synthetic Example 63 Synthesis of 4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • From methyl 4-[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (120 mg, 0.26 mmol) synthesized in Synthetic Example 62, the desired product was obtained in the same manner as in Synthetic Example 42 as a pale yellow solid (50 mg, yield 43%).
  • 1H-NMR (ppm in DMSO-d6).
  • δ 7.58-7.68 (m, 2H), 7.97-8.60 (m, 7H).
  • LC/MS (ES−) 447.
    • Synthetic Example 64 Synthesis of 4-{[(2-{1-[5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}benzoic acid
  • From 2-(3-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) synthesized in Reference Synthetic Example 49, the desired product was obtained in the same manner as in Synthetic Example 51 as a light brown solid (38 mg, 47%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 2.41 (s, 3H), 7.57-8.44 (m, 9H).
  • LC/MS (ES+) 480.
    • Synthetic Example 65 Synthesis of methyl 2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • To a suspension of 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (54.8 mg, 0.2 mmol) and methyl 2-acetamino-4-hydrazinocarbonylbenzoate (50.2 mg, 0.2 mmol) in isopropyl alcohol (2 mL), tosylic acid monohydrate (11.4 mg, 0.06 mmol) was added, and the mixture was heated with reflux for 12 hours. The precipitated solid was filtered to obtain 84 mg of the desired product as a pale yellow solid (yield 83%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.29 (s, 9H), 2.13 (s, 3H), 2.49 (s, 3H), 3.86 (s, 3H), 7.42 (d, 2H, J=8.4 Hz), 7.68-7.71 (m, 3H), 7.96-7:98 (m, 2H), 8.53 (s, 1H), 10.54 (brs, 1H), 11.48 (brs, 1H), 12.21 (brs, 1H).
  • LC/MS (ESI) 507 (M+).
    • Synthetic Example 66 Synthesis of 2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • To a suspension of methyl 2-acetamino-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}-hydrazino)carbonyl]benzoate (50.8 mg, 0.1 mmol) in isopropyl alcohol (1.0 mL), 0.2 M sodium hydroxide aqueous solution (1.1 mL, 0.22 mmol) was added, and the mixture was stirred at room temperature for 6 hours. After completion of the stirring, 1 M hydrochloric acid (220 μL) was added, and the precipitated solid was filtered and then washed with methanol to obtain 17.5 mg of the desired product as a pale yellow solid (yield 35%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.29 (s, 9H), 2.16 (s, 3H), 2.49 (s, 3H), 7.42 (d, 2H, J=8.4 Hz), 7.64 (d, 1H, J=8.1 Hz), 7.70 (d, 2H, J=8.4 Hz), 7.98 (s, 1H), 8.07 (d, 1H, J=8.1 Hz), 8.87 (s, 1H), 11.05 (brs, 1H), 11.47 (brs, 1H), 12.22 (brs, 1H).
  • LC/MS (ESI) 493 (M+).
    • Synthetic Example 67 Synthesis of methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
  • From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (57.4 mg, 0.2 mmol), methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (40.0 mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 81.2 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 87%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.88 (s, 3H), 7.64-7.71 (m, 2H), 7.91 (d, 1H, J=3.6 Hz), 8.05-8.13 (m, 3H), 11.57 (brs, 1H).
  • LC/MS (ESI) 468, 470 (M+).
    • Synthetic Example 68 Synthesis of 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
  • From methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (56.3 mg, 0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.89 mL, 0.38 mmol), 7.5 mg of the desired product was obtained in the same manner as in Synthetic Example 66 as a pale yellow solid (yield 14%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ=7.64-7.72 (m, 2H), 7.91 (d, 1H, J=3.6 Hz), 8.06-8.14 (m, 3H), 11.54 (brs, 1H).
  • LC/MS (ESI) 454, 456 (M+).
    • Synthetic Example 69 Synthesis of methyl 5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
  • From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (57.3 mg, 0.2 mmol), methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (40.0 mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 68.0 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 73%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.86 (s, 3H), 7.75 (d, 2H, J=8.4 Hz), 7.90 (d, 1H, J=4.2 Hz), 7.98 (d, 2H, J=8.4 Hz), 8.08 (d, 1H, J=4.2 Hz), 8.15 (s, 1H), 11.56 (brs, 1H).
  • LC/MS (ESI) 468 (M+).
    • Synthetic Example 70 Synthesis of 5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
  • To a suspension of methyl 5-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (56.2 mg, 0.12 mmol) in t-butanol (1.2 mL), 0.2 M sodium hydroxide aqueous solution (1.26 mL, 0.25 mmol) was added, and the mixture was stirred at room temperature for 4 hours. After completion of the stirring, 1 M hydrochloric acid (252 μL) was added, and the precipitated solid was filtered and washed with methanol to obtain 14.9 mg of the desired product as an orange solid (yield 27%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.76 (d, 2H, J=8.4 Hz), 7.81 (d, 1H, J=3.9 Hz), 8.00 (d, 2H, J=8.4 Hz), 8.06 (d, 1H, J=3.9 Hz), 8.16 (s, 1H), 11.53 (brs, 1H).
  • LC/MS (ESI) 454 (M+).
    • Synthetic Example 71 Synthesis of methyl 2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (57.3 mg, 0.2 mmol), methyl 4-hydrazinocarbonyl-2-nitrobenzoate (47.8 mg, 0.2 mmol) and tosylic acid monohydrate (11.4 mg, 0.06 mmol), 81.7 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 81%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ=3.89 (s, 3H), 7.75 (d, 2H, J=8.4 Hz), 8.00 (d, 2H, J=8.4 Hz), 8.04 (d, 1H, J=7.8 Hz), 8.17 (s, 1H), 8.35 (d, 1H, J=7.8 Hz), 8.58 (s, 1H), 11.69 (brs, 1H).
  • LC/MS (ESI) 507 (M+)
    • Synthetic Example 72 Synthesis of 2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • From methyl 2-nitro-4-[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino) carbonyl]benzoate (60.9 mg (0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.26 mL, 0.25 mmol), 38.2 mg of the desired product was obtained in the same manner as in Synthetic Example 70 as a pale yellow solid (yield 65%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 7.76 (d, 2H, J=8.1 Hz), 8.00-8.05 (m, 3H), 8.18 (s, 1H), 8.31 (d, 1H, J=8.1 Hz), 8.52 (s, 1H), 11.68 (brs, 1H).
  • LC/MS (ESI) 493 (M+).
    • Synthetic Example 73 Synthesis of methyl 2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • From 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (59.0 mg, 0.215 mmol), methyl 2-fluoro-4-hydrazinocarbonylbenzoate (45.6 mg, 0.215 mmol) and tosylic acid monohydrate (12.3 mg, 0.0645 mmol), 94.9 mg of the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (yield 94%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.29 (s, 9H), 3.91 (s, 3H), 7.43 (d, 2H, J=8.4 Hz), 7.71 (d, 2H, J=8.4 Hz), 7.85-7.94 (m, 2H), 8.01-8.08 (m, 2H), 11.50 (brs, 1H), 12.17 (brs, 1H).
  • LC/MS (ESI) 468 (M+).
    • Synthetic Example 74 Synthesis of 2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • From methyl 2-fluoro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (56.2 mg, 0.12 mmol) and 0.2 M sodium hydroxide aqueous solution (1.26 mL, 0.25 mmol), 46.3 mg of the desired product was obtained in the same manner as in Synthetic Example 70 as a pale yellow solid (yield 85%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.29 (s, 9H), 7.43 (d, 2H, J=8.4 Hz), 7.71 (d, 2H, J=8.4 Hz), 7.83-7.94 (m, 2H), 7.99-8.04 (m, 2H), 11.48 (brs, 1H), 12.18 (brs, 1H).
  • LC/MS (ESI) 452 (M+).
    • Synthetic Example 75 Synthesis of methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}hydrazino)-carbonyl]benzoate
  • A suspension of 2-(4-t-butylphenyl)-3-hydroxy-4-isopropylcarbonylthiophene (100 mg, 0.33 mmol), 4-hydrazinocarbonylmethylbenzoate (70 mg, 0.36 mmol) and p-tosylic acid monohydrate in isopropyl alcohol, was dehydrated with reflux for 2 days. After completion of the reaction, the reaction solution was cooled to room temperature and filtered to obtain the desired product as a yellow solid (92 mg, yield 58%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 1.38 (s, 3H), 1.41 (s, 3H), 3.91 (s, 3H), 7.43 (d, J=8.3 Hz, 2H), 7.71 (d, J=8.3 Hz, 2H), 8.02-8.13 (m, 5H).
  • LC/MS (ES+) 479.
    • Synthetic Example 76 Synthesis of 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}hydrazino)carbonyl]benzoic acid
  • Using methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl](isopropyl)methylene}-hydrazino)carbonyl]benzoate (80 mg, 0.17 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 70 as a pale yellow solid (19 mg, yield 24%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 1.39-1.41 (m, 6H), 7.42-7.44 (m, 2H), 7.70-7.73 (m, 2H), 8.00-8.10 (m, 6H).
  • LC/MS (ES+) 465.
    • Synthetic Example 77 Synthesis of methyl 2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • Using 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) and methyl 2-nitro-4-hydrazinocarbonylbenzoate (93 mg, 0.39 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a yellow solid (147 mg, yield 83%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 3.91 (s, 3H), 7.55-7.75 (m, 2H), 8.05-8.20 (m, 3H), 8.30-8.40 (m, 1H), 8.50-8.65 (m, 1H).
  • LC/MS (ES−) 507.
    • Synthetic Example 78 Synthesis of 2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • Using methyl 2-nitro-4-[(2-{1-[(5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (137 mg, 0.27 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 66 as a yellow solid (68 mg, yield 51%).
  • LC/MS (ES+) 494, 495.
    • Synthetic Example 79 Synthesis of methyl 2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • Using 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (55 mg, 0.20 mmol) and methyl 2-bromo-4-hydrazinocarbonylbenzoate (60 mg, 0.22 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a yellow solid (92 mg, yield 87%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.5 Hz, 2H), 7.71 (d, J=8.5 Hz, 2H), 7.91 (d, J=8.0 Hz, 1H), 8.01-8.0.3 (m, 2H), 8.27 (s., 1H).
  • LC/MS (ES−) 528.
    • Synthetic Example 80 Synthesis of 2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • Using methyl 2-bromo-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (82 mg, 0.15 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 66 as a yellow solid (67 mg, yield 87%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.31 (s, 9H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.4 Hz, 2H), 7.87-7.89 (m, 1H), 7.97-8.01 (m, 2H), 8.24 (s, 1H).
  • LC/MS (ES+) 517, 519.
    • Synthetic Example 81 Synthesis of methyl 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • Using 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (55 mg, 0.20 mmol) and methyl 2-chloro-4-hydrazinocarbonylbenzoate (50 mg, 0.22 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a pale yellow solid (86 mg, yield 89%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.30 (s, 9H), 3.91 (s, 3H), 7.43 (d, J=8.4 Hz, 2H), 7.71 (d, J=8.5 Hz, 2H), 7.97-8.01 (m, 3H), 8.12 (s, 1H).
  • LC/MS (ES−) 483, 485.
    • Synthetic Example 82 Synthesis of 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoic acid
  • Using methyl 2-chloro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonyl]benzoate (76 mg, 0.16 mmol) as the starting material, the desired product was obtained in the same manner as in Synthetic Example 66 as a pale yellow solid (60 mg, yield 80%).
  • LC/MS (ES+) 471, 473.
    • Synthetic Example 83 Synthesis of methyl 4-[(2-{1-[2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
  • To a suspension of 2-bromo-5-(4-t-butylphenyl)-4-hydroxy-3-methylcarbonylthiophene (1.00 g, 2.83 mmol) synthesized in Reference Synthetic Example 55 and 4-hydrazinocarbonylmethylbenzoate (550 mg, 2.83 mmol) in isopropyl alcohol (28.3 mL), tosylic acid monohydrate (146 mg, 0.85 mmol) was added, and the mixture was heated with reflux for about 1 hour. The reaction solution was concentrated, and then purified with a silica gel column chromatography (chloroform, and then chloroform/ethyl acetate=95/5) to obtain the desired product as a yellow solid (935 mg, yield 62%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 1.29 (s, 9H), 2.61 (s, 3H), 3.91 (s, 3H), 7.44 (d, J=8.4 Hz, 2H), 7.65 (d, J=8.4 Hz, 2H), 8.06-8.14 (m, 4H), 11.69 (s, 1H), 12.29 (s, 1H).
  • LC/MS (ES+) 529, 531.
    • Synthetic Example 84 Synthesis of methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate
  • From 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (0.70 mmol, 200 mg) synthesized in Synthetic Example 1, methyl 2-nitro-4-hydrazinocarbonylbenzoate (0.70 mmol, 167.8 mg) of Reference Synthetic Example 40 and tosylic acid monohydrate (36.2 mg, 0.21 mmol), 311.1 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 88%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.61 (s, 1H), 9.85 (s, 1H), 8.58 (d, J=1.4 Hz, 1H), 8.34 (dd, J=1.4, 8.0 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.86 (d, J=1.9 Hz, 2H), 7.80 (d, J=8.4 Hz, 1H), 7.61 (dd, J=1.9, 8.4 Hz, 1H), 3.90 (s, 6H), 2.46 (s, 3H).
  • LC-MS (ESI) 505 (M+)
    • Synthetic Example 85 Synthesis of 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid
  • From methyl 4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoate (0.40 mmol, 200 mg) and 1 M sodium hydroxide aqueous solution (1.98 mL, 1.98 mmol), 130.5 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 67%).
  • 1H-NMR (ppm in DMSO-d6) 11.58 (s, 1H), 9.86 (s, 1H), 8.50 (s, 1H), 8.27-8.32 (m, 1H), 8.01 (d, J=8.0 Hz, 1H), 7.85-7.86 (m, 1H), 7.80 (d, J=8.5 Hz, 1H), 7.60-7.62 (m, 1H), 3.90 (s, 3H), 2.46 (s, 3H).
  • LC-MS (ESI) 491 (M+)
    • Synthetic Example 86 Synthesis of methyl 4-{[2-(1-[4-hydroxy-1-methyl-5-[-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]ethylidene)hydrazino]carbonyl}-2-nitrobenzoate
  • From 1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (0.70 mmol, 200 mg) synthesized in Synthetic Example 11, methyl. 2-nitro-4-hydrazinocarbonylbenzoate (0.70 mmol, 168.3 mg) of Reference Synthetic Example 40 and tosylic acid monohydrate (36.4 mg, 0.21 mmol), 214.7 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 60%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.62 (s, 1H), 9.88 (s, 1H), 8.58 (d, J=1.5 Hz, 1H), 8.35 (dd, J=1.5, 8.0 Hz, 1H), 8.05 (d, J=8.0 Hz, 1H), 7.90 (ABq, J=8.7 Hz, 2H), 7.84 (ABq, J=8.7 Hz, 2H), 3.93 (s, 3H), 3.90 (s, 3H), 2.48 (s, 3H).
  • LC-MS (ESI) 505 (M+).
    • Synthetic Example 87 Synthesis of 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-nitrobenzoic acid
  • From methyl 4-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-nitrobenzoate (0.30 mmol, 150 mg) and 1 M sodium hydroxide aqueous solution (1.48 mL, 1.48 mmol), 106.0 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (yield 73%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.59 (s, 1H), 9.88 (s, 1H), 8.50 (s, 1H), 8.28-8.31 (m, 1H), 8.02 (d, J=8.0 Hz, 1H), 7.90 (ABq, J=8.7 Hz, 2H), 7.84 (ABq, J=8.7 Hz, 2H), 3.93 (s, 3H), 2.47 (s, 3H).
  • LC-MS (ESI) 491 (M+).
    • Synthetic Example 88 Synthesis of methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate
  • From 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (200 mg, 0.70 mmol) synthesized in Synthetic Example 1, methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (0.70 mmol, 140.4 mg) of Reference. Synthetic Example 39 and tosylic acid monohydrate (36.2 mg, 0.21 mmol), 314.1 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 96%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.47 (s, 1H), 9.76 (s, 1H), 8.04-8.07 (m, 1H), 7.79-7.91 (m, 3H), 7.56-7.61 (s, 1H), 3.87 (s, 6H), 2.46 (s, 3H).
  • LC-MS (ESI) 466 (M+).
    • Synthetic Example 89 Synthesis of 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
  • From methyl 5-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylate (200 mg, 0.43 mmol) and 1 M sodium hydroxide aqueous solution (2.13 mL, 2.13 mmol), 153.3 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a yellow solid (yield 84%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.43 (s, 1H), 9.78 (s, 1H), 8.03-8.32 (m, 1H), 7.79-7.85 (m, 3H), 7.58-7.61 (m, 1H), 3.89 (s, 3H), 2.46 (s, 3H).
  • LC-MS (ESI) 452 (M+).
    • Synthetic Example 90 Synthesis of methyl 5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylate
  • From 1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (200 mg, 0.70 mmol) synthesized in Synthetic Example 11, methyl 5-hydrazinocarbonyl-2-thiophenecarboxylate (0.70 mmol, 140.9 mg) of Reference Synthetic Example 39 and tosylic acid monohydrate (36.4 mg, 0.21 mmol), 188.2 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (yield 57%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.48 (s, 1H), 9.78 (s, 1H), 8.06-8.08 (m, 1H), 7.82-7.91 (m, 5H), 3.92 (s, 3H), 3.87 (s, 3H), 2.47 (s, 3H).
  • LC-MS (ESI) 466 (M+).
    • Synthetic Example 91 Synthesis of 5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylic acid
  • From methyl 5-{[2-(1-{4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}ethylidene)hydrazino]carbonyl}-2-thiophenecarboxylate (150 mg, 0.32 mmol) and 1 M sodium hydroxide aqueous solution (1.60 mL, 1.60 mmol), 89.0 mg of the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (yield 61%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.44 (s, 1H), 9.80 (s, 1H), 8.03-8.04 (m, 1H), 7.80-7.91 (m, 5H), 3.92 (s, 3H), 2.47 (s, 3H).
  • LC-MS (ESI) 452 (M+).
    • Synthetic Example 92 Synthesis of methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate
  • Dimethylformamide (1.3 mL) and conc. hydrochloric acid (1 drop) were added to 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (71 mg, 0.26 mmol) synthesized in Reference Synthetic Example 33 and methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate (70 mg, 0.26 mmol) synthesized in Reference Synthetic Example 56, and the mixture was stirred at room temperature for 2 days. The precipitated solid was filtered to obtain 110 mg of the desired product as a pale yellow solid (yield 81%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.29 (bs, 1H), 10.67 (bs, 1H), 8.57 (bs, 1H), 7.87-8.03 (m, 3H), 7.67 (d, J=8.4 Hz, 2H), 7.41 (d, J=8.4 Hz, 2H), 3.83 (s, 3H), 2.40 (s, 3H), 1.28 (s, 9H).
  • LC/MS (ESI) 526.
    • Synthetic Example 93 Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoic acid
  • Methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate (95 mg, 0.18 mmol) synthesized in Synthetic. Example 92 was dissolved in isopropyl alcohol (1.8 mL), and 0.2 M sodium hydroxide aqueous solution (2.0 mL, 0.40 mmol) was added thereto, followed by stirring overnight at room temperature. After completion of the stirring, 1 M hydrochloric acid (0.40 mL, 0.40 mmol) and water were added thereto, and the precipitated solid was filtered to obtain 57 mg of the desired product as a pale yellow solid (yield 61%).
  • 1H-NMR (ppm in DMSO-d6)
  • δ 11.29 (bs, 1H), 10.64 (bs, 1H), 8.50 (bs, 1H), 7.87-8.00 (m, 3H), 7.69 (d, J=8.4 Hz, 2H), 7:43 (d, J=8.4 Hz, 2H), 2.41 (s, 3H), 1.29 (s, 9H).
  • LC/MS (ESI) 512.
    • Synthetic Example 94 Synthesis of methyl 4-{([(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate
  • From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg, 0.21 mmol) synthesized in Reference Synthetic Example 34, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (88 mg, yield 78%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.35 (bs, 1H), 10.70 (bs, 1H), 8.57 (bs, 1H), 8.14 (s, 1H), 8.01-8.04 (m, 2H), 7.89-7.91 (m, 1H), 7.65-7.74 (m, 2H), 3.84 (s, 3H), 2.42 (s, 3H).
  • LC/MS (ESI) 538.
    • Synthetic Example 95 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoic acid
  • From methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (70 mg, 0.13 mmol) synthesized in Synthetic Example 94, the desired product was obtained in the same manner as in Synthetic Example 93 as a pale yellow solid (43 mg, yield 63%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.32 (bs, 1H), 10.66 (bs, 1H), 8.48 (bs, 1H), 8.13 (s, 1H), 7.87-8.02 (m, 3H), 7.64-7.74 (m, 2H), 2.41 (s, 3H).
  • LC/MS (ESI) 524.
    • Synthetic Example 96 Synthesis of methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate
  • From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg, 0.21 mmol) synthesized in Reference Synthetic Example 35, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (103 mg, yield 91%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.36 (bs, 1H), 10.72 (bs, 1H), 8.58 (bs, 1H), 8.17 (s, 1H), 7.89-8.04 (m, 4H), 7.76 (d, J=8.3 Hz, 2H), 3.84 (s, 3H), 2.43 (s, 3H).
  • LC/MS (ESI) 538.
    • Synthetic Example 97 Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]-amino}-2-nitrobenzoic acid
  • From methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (90 mg, 0.17 mmol) synthesized in Synthetic Example 96, the desired product was obtained in the same manner as in Synthetic. Example 93 as a pale yellow solid (69 mg, yield 79%).
  • 1H-NMR (ppm in DMSO),
  • δ 11.34 (bs, 1H), 10.65-10.67 (m, 1H), 8.49 (bs, 1H), 8.16 (s, 1H), 7.88-8.01 (m, 4H), 7.76 (d, J=8.5 Hz, 2H), 2.43 (s, 3H).
  • LC/MS (ESI) 524.
    • Synthetic Example 98 Synthesis of methyl 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylate
  • Dimethylformamide (1.3 ml) and conc. hydrochloric acid (1 drop) were added to 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (70 mg, 0.26 mmol) synthesized in Reference Synthetic Example 33 and methyl 5-hydrazinocarbonothioylamino-2-thiophenecarboxylate (59 mg, 0.26 mmol) synthesized in Reference Synthetic Example 57, and the mixture was stirred overnight at room temperature. Water was added, and the precipitated solid was filtered. The obtained solid was extracted with chloroform, dried over anhydrous sodium sulfate. The organic layer was concentrated, and purified with a silica gel column chromoatography (chloroform/methanol=95/5) to obtain the desired product as a pale yellow solid (1.12 mg, yield 90%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.63 (bs, 1H), 11.18 (bs, 1H), 8.01 (bs, 1H), 7.72 (d, J=8.5 Hz, 2H), 7.67 (d, J=4.4 Hz, 1H), 7.46 (d, J=8.5 Hz, 2H), 6.92 (d, J=4.4 Hz, 1H), 3.82 (s, 3H), 2.41 (s, 3H), 1.32 (s, 9H).
  • LC/MS (ESI) 487.
    • Synthetic Example 99 Synthesis of 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylic acid
  • Methyl 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylate (85 mg, 0.18 mmol) synthesized in Synthetic Example 98 was dissolved in isopropyl alcohol (1.8 ml), and 0.2 M sodium hydroxide aqueous solution (1.95 ml, 0.39 mmol) was added thereto, following by stirring overnight at room temperature. Then 0.2 M sodium hydroxide aqueous solution (0.96° ml, 0.19 mmol) was added thereto, following by stirring overnight at 45° C. After completion of the stirring, 1 M hydrochloric acid (0.58 ml, 0.58 mmol) was added. The precipitated solid was filtered to obtain 2.7 mg of the desired product as a pale yellow solid (yield 3%).
  • LC/MS (ESI) 473.
    • Synthetic Example 100 Synthesis of methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoate
  • From 2-(4-t-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (60 mg, 0.22 mmol) synthesized in Reference Synthetic Example 33, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (118 mg, yield 100%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.21 (bs, 1H), 10.50 (bs, 1H), 8.21 (bs, 1H), 7.97 (d, J=8.5 Hz, 1H), 7.89 (d, J=8.5 Hz, 1H), 7.68-7.71 (m, 3H), 7.43 (d, J=8.3 Hz, 2H), 3.85 (s, 3H), 2.40 (s, 3H), 1.29 (s, 9H).
  • LC/MS (ESI) 515.
    • Synthetic Example 101 Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoic acid
  • Methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (100 mg, 0.19 mmol) synthesized in Synthetic Example 100 was dissolved in isopropyl alcohol (1.9 ml), and 0.2 M sodium hydroxide aqueous solution (2.1 ml, 0.42 mmol) was added thereto, following by stirring overnight at room temperature, then at 45° C. for 1 day. Then 0.2 M sodium hydroxide aqueous solution (1.1 ml, 0.22 mmol) was added thereto, following by stirring at 45° C. for 5.5 hours. After completion of the stirring, 1 M hydrochloric acid (0.64 ml, 0.64 mmol) was added. The precipitated solid was filtered, and purified with a silica gel plate (chloroform/methanol=9/1) to obtain the desired product as a yellow solid (24 mg, yield 25%).
  • 1H-NMR (ppm in DMSO)
  • δ 10.48 (bs, 1H), 8.18 (bs, 1H), 7.84-7.94 (m, 2H), 7.65-7.68 (m, 3H), 7.40-7.43 (m, 2H), 2.41 (s, 3H), 1.29 (s, 9H).
  • LC/MS (ESI) 501.
    • Synthetic Example 102 Synthesis of methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate
  • From 1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (63 mg, 0.23 mmol) synthesized in Synthetic Example 3, the desired product was obtained in the same manner as in Synthetic Example 92 as a yellow solid (121 mg, yield 100%).
  • 1H-NMR (ppm in DMSO)
  • δ 10.53 (bs, 1H), 8.60-8.61 (m, 1H), 7.87-8.06 (m, 2H), 7.47-7.60 (m, 4H), 3.84 (s, 3H), 3.82 (s, 3H), 2.41 (s, 3H), 1.33 (s, 9H).
  • LC/MS (ESI) 524.
    • Synthetic Example 103 Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
  • Methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (100 mg, 0.19 mmol) synthesized in Synthetic Example 102 was dissolved in methanol (6.7 ml), and 1 M sodium hydroxide aqueous solution (0.96 ml, 0.96 mmol) was added thereto, following by stirring overnight at room temperature. After completion of the stirring, the reaction solution was washed with ethyl acetate, and to the aqueous layer, 1 M hydrochloric acid was added. The precipitated solid was filtered to obtain 27 mg of the desired product as a pale yellow solid (yield 28%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.10 (bs, 1H), 10.50 (bs, 1H), 8.49 (bs, 1H), 7.86-7.97 (m, 2H), 7.47-7.59 (m, 4H), 3.82-3.83 (m, 3H), 2.41 (s, 3H), 1.33-1.34 (m, 9H).
  • LC/MS (ESI) 510.
    • Synthetic Example 104 Synthesis of methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}-hydrazino)carbonothioyl]amino}-2-nitrobenzoate
  • Dimethylformamide (1 ml) and conc. hydrochloric acid (1 drop) were added to 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (60 mg, 0.21 mmol) synthesized in Synthetic Example 1 and methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate (57 mg, 0.21 mmol) synthesized in Reference Synthetic Example 56, and the mixture was stirred at room temperature for 21 hours. Water was added, and the precipitated solid was filtered, purified with a silica gel column chromoatography (n-hexane/ethyl acetate=1/1 then chloroform/methanol=95/5). The obtained solid was extracted with ethyl acetate, washed with a saturated ammonium chloride aqueous solution, saturated sodium chloride aqueous solution. The organic layer was concentrated to obtain the desired product as a pale yellow solid (104 mg, yield 92%).
  • 1H-NMR (ppm in DMSO)
  • δ 8.57 (bs, 1H), 8.03-8.05 (m, 1H), 7.78-7.90 (m, 3H), 7.56-7.59 (m, 1H), 3.86 (s, 3H), 3.84 (s, 3H), 2.41 (s, 3H).
  • LC/MS (ESI) 536.
    • Synthetic Example 105 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
  • Methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoate (100 mg, 0.19 mmol) synthesized in Synthetic Example 104 was dissolved in methanol (3 ml), and 1 M sodium hydroxide aqueous solution (0.74 ml, 0.74 mmol) was added thereto, following by stirring overnight at room temperature. After completion of the stirring, 1 M hydrochloric acid (0.74 ml, 0.74 mmol) and water were added thereto. The precipitated solid was recovered by filtration, washed with water, isopropyl alcohol, and chloroform. The obtained solid was stirred in chlorororm, and then filtered to obtain 37 mg of the desired product as a yellow solid (yield 48%).
  • 1H-NMR (ppm in DMSO)
  • δ 8.47 (bs, 1H), 7.77-7.93 (m, 4H), 7.56-7.59 (m, 1H), 3.86 (s, 3H), 2.42 (s, 3H).
  • LC/MS (ESI) 522.
    • Synthetic Example 106 Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
  • From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone, synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Examples 102 and 103 as a yellow solid (22.6 mg).
  • 1H-NMR (ppm in DMSO)
  • δ 8.4.8 (bs, 1H), 7.50-8.00 (m, 6H), 3.88 (s, 3H), 2.42 (s, 3H).
  • LC/MS (ESI) 488
    • Synthetic Example 107 Synthesis of 4-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-nitrobenzoic acid
  • From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Example 58 as a pale yellow solid (19.1 mg).
  • 1H-NMR (ppm in DMSO)
  • δ 11.5 (1H, s), 9.73 (1H, s), 8.49 (1H, s), 8.28 (1H, d, J=8 Hz), 8.01 (1H, d, J=8 Hz), 7.65-7.55 (4H, m), 3.87 (3H, s), 2.46 (3H, s).
  • LC/MS (ESI) 457
    • Synthetic Example 108 Synthesis of 5-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]-2-thiophenecarboxylic acid
  • From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Examples 33 and 34 as a yellow solid (20.2 mg).
  • 1H-NMR (ppm in DMSO)
  • δ 11.4 (1H, s), 9.64 (1H, s), 8.02 (1H, d, J=3 Hz), 7.80 (1H, d, J=3 Hz), 7.5-7.7 (4H, m), 3.86 (3H, s), 2.45 (3H, s).
  • LC/MS (ESI) 418
    • Synthetic Example 109 Synthesis of 4-[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonyl]benzoic acid
  • From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone synthesized in the same manner as in Synthetic Example 1, the desired product was obtained in the same manner as in Synthetic Example 3 as a yellow solid (47.4 mg).
  • 1H-NMR (ppm in DMSO)
  • δ 11.4 (1H, s), 9.83 (1H, s), 7.90-8.20 (4H, m), 7.50-7.70 (4H, m), 3.86 (3H, s), 2.45 (3H, s).
  • LC/MS (ESI) 412
    • Synthetic Example 110 Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-nitrobenzoic acid
  • From methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoate (70 mg, 0.13 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a yellow solid (42 mg, yield 62%).
  • 1H-NMR (ppm in DMSO) δ 8.48 (bs, 1H), 7.80-8.00 (m, 6H), 3.88 (s, 3H), 2.42 (s, 3H).
  • LC/MS (ESI) 522.
    • Synthetic Example 111 Synthesis of 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
  • From methyl 4-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (82 mg, 0.16 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a brown solid (40 mg, yield 50%).
  • 1H-NMR (ppm in DMSO)
  • δ 8.12-8.26 (m, 1H), 7.50-7.81 (m, 6H), 3.82 (s, 3H), 2.41 (s, 3H), 1.32 (s, 9H).
  • LC/MS (ESI) 499.
    • Synthetic Example 112 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
  • From methyl 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (105 mg, 0.20 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a pale yellow solid (54 mg, yield 52).
  • 1H-NMR (ppm in DMSO)
  • δ 8.09 (bs, 1H), 7.77-7.85 (m, 3H), 7.65-7.68 (m, 1H), 7.55-7.58 (m, 1H), 3.84 (s, 3H), 2.39 (s, 3H).
  • LC/MS (ESI) 511.
    • Synthetic Example 113 Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
  • From methyl 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoate (60 mg, 0.11 mmol), the desired product was obtained in the same manner as in Synthetic Examples 104 and 105 as a pale yellow solid (25 mg, yield 42%).
  • 1H-NMR (ppm in DMSO)
  • δ 8.11 (bs, 1H), 7.80-7.94 (m, 5H), 7.67-7.70 (m, 1H), 3.88 (s, 3H), 2.41 (s, 3H).
  • LC/MS (ESI) 511.
    • Synthetic Example 114 Synthesis of 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid 1) Synthesis of 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid
  • To methyl 5-hydrazinocabonothioylamino-2-thiophenecarboxylate (1.21 mmol, 280 mg) obtained in Reference Synthetic Example 57, methanol (2.4 ml) was added, and 0.2 M aqueous sodium hydroxide (3 eq, 18.2 ml) was added at room temperature. After stirring of 1.5 hours at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (3 eq, 3.63 ml) was added. The precipitated solid was recovered by filtration, washed with water and chloroform and dried by means of a vacuum pump. The desired product was obtained as a pale yellow solid (230 mg, yield 87.6% (LC purity 90%)).
  • 1H-NMR (ppm in DMSO)
  • δ 9.56 (bs, 1H), 7.47 (d, J=4.1 Hz, 1H), 7.07 (bs, 1H), 6.91 (bs, 1H).
  • LC/MS (ESI) 217.
    • 2) Synthesis of 5-{[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
  • From 1-[5-(4-t-butylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (40.0 mg, 0.15 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (35.5 mg, 0.15 mmol), the desired product was obtained in the same manner as in Synthetic Example 2 as a yellow solid (57.3 mg, yield 83%).
  • 1H-NMR (ppm in DMSO)
  • δ 7.47-7.56 (m, 5H), 6.90 (bs, 1H), 3.82 (s, 3H), 2.39 (s, 3H), 1.34 (s, 9H).
  • LC/MS (ESI) 471.
    • Synthetic Example 115 Synthesis of 5-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
  • From 1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (40.0 mg, 0.14 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33.9 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (62.2 mg, yield 92%).
  • 1H-NMR (ppm in DMSO)
  • δ 7.84 (d, J=1.7 Hz, 1H), 7.80 (d, J=8.3 Hz, 1H), 7.54-7.60 (m, 2H), 6.90 (bs, 1H), 3.86 (s, 3H), 2.39 (s, 3H).
  • LC/MS (ESI) 483.
    • Synthetic Example 116 Synthesis of 5-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
  • From 1-[5-(4-trifluoromethylphenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (40.0 mg, 0.14 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (34.0 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (55.8 mg, yield 82%).
  • 1H-NMR (ppm in DMSO)
  • δ 7.81-7.91 (m, 4H), 7.55 (d, J=4.1 Hz, 1H), 6.90 (bs, 1H), 3.89 (s, 3H), 2.40 (s, 3H).
  • LC/MS (ESI) 483.
    • Synthetic Example 117 Synthesis of 5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-thiophenecarboxylic acid
  • From 1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (37.5 mg, 0.15 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (33 mg, 0.14 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a pale yellow solid (62.0 mg, yield 83%).
  • 1H-NMR (ppm in DMSO)
  • δ 7.45-7.56 (m, 5H), 6.94 (bs, 1H), 3.87 (s, 3H), 2.43 (s, 3H).
  • LC/MS (ESI) 449.
    • Synthetic Example 118 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoic acid 1) Synthesis of 4-hydrazinocabonothioylamino-2-chlorobenzoic acid
  • To methyl 4-hydrazinocabonothioylamino-2-chlorobenzoate (1.16 mmol, 300 mg) obtained in Reference Synthetic Example 58, methanol (2.3 ml) was added, and 0.2 M aqueous sodium hydroxide (2.1 eq, 12.1 ml) was added at room temperature. After stirring of 1.5 hours at 60° C., the reactor was cooled to room temperature, and 1 M hydrochloric acid (2.1 eq, 2.43 ml) was added. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump. 4-Hydrazinocabonothioylamino-2-chlorobenzoic acid was obtained as a colorless solid (262.8 mg, yield 92.6%).
  • 1H-NMR (ppm in DMSO)
  • δ 9.48 (bs, 1H), 8.22 (bs, 1H), 7.75-7.77 (m, 3H).
  • LC/MS (ESI) 245.
    • 2) Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
  • From 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (50 mg, 0.17 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (42.8 mg, 0.17 mmol), the desired product was obtained in the same manner as in Synthetic Example 50 as a pale yellow solid (61.1 mg, yield 68%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.20 (bs, 1H), 10.46 (bs, 1H), 8.14 (bs, 1H), 8.11 (s, 1H), 8.02 (d, J=1.9 Hz, 1H), 7.87 (d, J=8.5 Hz, 1H), 7.64-7.74 (m, 3H), 2.40 (s, 3H).
  • LC/MS (ESI) 513.
    • Synthetic Example 119 Synthesis of 4-{[(2-{1-[5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
  • From 2-(4-trifluoromethylphenyl)-3-hydroxy-4-methylcarbonylthiophene (50.0 mg, 0.17 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (42.9 mg, 0.17 mmol), the desired product was obtained in the same manner as in Synthetic Example 118 as a pale yellow solid (58.3 mg, yield 65%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.22 (bs, 1H), 10.47 (bs, 1H), 8.13-8.15 (m, 2H), 8.00 (d, J=8.3 Hz, 2H), 7.87 (d, J=8.5 Hz, 1H), 7.76 (d, J=8.3 Hz, 2H), 7.65-7.68 (m, 1H), 2.41 (s, 3H).
  • LC/MS (ESI) 513.
    • Synthetic Example 120 Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethylidene}hydrazino)-carbonothioyl]amino}-2-chlorobenzoic acid
  • From 1-[5-(4-dichlorophenyl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (37.5 mg, 0.15 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (36.9 mg, 0.15 mmol), the desired product was obtained in the same manner as in Synthetic Example 114 as a yellow solid (59.5 mg, yield 92%).
  • 1H-NMR (ppm in DMSO)
  • δ 7.40-8.40 (m, 7H), 3.78-3.84 (m, 3H), 2.40 (s, 3H).
  • LC/MS (ESI) 477.
    • Synthetic Example 121 Synthesis of 5-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-thiophenecarboxylic acid
  • From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25.3 mg, 0.10 mmol) and 5-hydrazinocabonothioylamino-2-thiophenecarboxylic acid (21.8 mg, 0.10 mmol), the desired product was obtained in the same manner as in Synthetic Example 50 as a pale yellow solid (37.1 mg, yield 82%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.54 (bs, 1H), 11.13 (bs, 1H), 8.04 (s, 1H), 7.80-7.82 (m, 2H), 7.87 (d, J=4.1 Hz, 1H), 7.46-7.50 (m, 2H), 6.86-6.87 (m, 1H), 2.39 (s, 3H).
  • LC/MS (ESI) 451.
    • Synthetic Example 122 Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-chlorobenzoic acid
  • From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25.2 mg, 0.1 mmol) and 4-hydrazinocabonothioylamino-2-chlorobenzoic acid (24.5 mg, 0.1 mmol), the desired product was obtained in the same manner as in Synthetic Example 50 as a pale yellow solid (41.9 mg, yield 88%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.21 (bs, 1H), 10.47 (bs, 1H), 8.15 (s, 1H), 8.05 (s, 1H), 7.87 (d, J=8.3 Hz, 1H), 7.77-7.81 (m, 2H), 7.66 (d, J=8.3 Hz, 1H), 7.46-7.48 (m, 2H), 2.40 (s, 3H).
  • LC/MS (ESI) 479.
    • Synthetic Example 123 Synthesis of 4-{[(2-{1-[5-(4-chlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonothioyl]amino}-2-nitrobenzoic acid
  • From 2-(4-chlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (21 mg, 0.083 mmol), the desired product was obtained in the same manner as in Synthetic Examples 92 and 93 as a pale yellow solid (35.2 mg, yield 86%).
  • 1H-NMR (ppm in DMSO)
  • δ 11.32 (bs, 1H), 10.67 (bs, 1H), 8.49 (s, 1H), 8.07 (s, 1H), 7.95-7.98 (m, 1H), 7.89 (d, J=8.4 Hz, 1H), 7.80 (d, J=8.6 Hz, 2H), 7.47 (d, J=8.6 Hz, 2H), 2.41 (s, 3H)
  • LC/MS (ESI) 490.
    • Synthetic Example 124 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazine)carbonothioyl]-amino}-benzenesulfonic acid potassium salt
  • A solution of 2-(3,4-dichlorophenyl)-4-(1-hydrorazono-ethyl)thiophen-3-ol (20 mg, 0.066 mmol) and 4-sulfophenyl isothiocyanate sodium salt monohydrate (25 mg, 0.099 mmol) in dimethylformamide (0.2 mL) was stirred at room temperature for 1 hour. To the reaction mixture was added ethanol (2 mL), then the precipitated solid was collected by filtration and dried by means of a vacuum pump to give a pale red solid.
  • To a solution of the solid in methanol (0.8 mL) was added 0.1M potassium hydroxide methanol solution (0.4 mL), then the reaction mixture was stirred at 40° C. for 10 minutes, evaporated and dried by means of a vacuum pump to give the desired product as a pale red solid. (yield 59%).
  • LC/MS: condition 8, retention time 5.32 (min)
  • LC/MS (ESI−) m/z; 514, 516 [M−1]−
    • Synthetic Examples 125-146
  • Table 17 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 124, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • TABLE 17
    yields O.P. R.T.
    S.E. (%) shapes L.C. ESI+ ESI− (min)
    125 65 pale yellow solid 8 515/517 513/515 4.85
    126 74 pale yellow solid 3 481/483 479/481 3.38
    127 81 white solid 8 480/482 478/480 5.01
    128 87 white solid 2 478 476 3.84
    129 72 white solid
    130 100 pale yellow solid 2 446/448 444/446 4.30
    131 87 white solid 2 478/480 476/478 3.87
    132 50 pale yellow solid 3 442 440 3.17
    133 89 white solid 3 490/492 488/490 3.54
    134 94 white solid 3 490/492 488/490 3.54
    135 59 white solid 3 496 494 3.55
    136 62 white solid 3 440 438 3.47
    137 85 pale yellow solid 3 440 438 3.49
    138 90 yellow solid 3 475 473 3.40
    139 100 white solid 2 513 511 3.74
    140 95 white solid 2 513/515 511/513 3.82
    141 60 pale yellow solid 3 446/448 444/446 3.45
    142 74 pale yellow solid 3 481/483 479/481 3.37
    143 81 pale yellow solid 3 525/527 523/525 3.45
    144 83 white solid 3 515 513 3.45
    145 76 pale yellow solid 8 531 529 4.85
    146 83 pale yellow solid 6 503 501 3.60
    147 pale yellow solid
    • Synthetic example 148 Synthesis of 4-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazine)carbonothioyl]-amino}-phenol
  • To a solution of 4-aminophenol (11 mg, 0.099 mmol) in dimethylformamide (0.2 mL) was added N,N′-thiocarbonyl diimidazole (20 mg, 0.112 mmol), and the reaction mixture was stirred at room temperature for 0.5 hour. To the resultant mixture, 2-(3,4-dichlorophenyl)-4-(1-hydrorazonoethyl)thiophen-3-ol (20 mg, 0.066 mmol) was added portionwise. The reaction mixture was stirred at 35° C. for 1 hour and quenched with methanol (2 mL) and water (2 mL), and then the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a white solid (yield 50%).
  • LC/MS: condition 8, retention time 5.00 (min)
  • LC/MS (ESI+) m/z; 452, 454 [M+1]+
  • LC/MS (ESI−) m/z; 450, 452 [M−1]−
    • Synthetic examples 149-166
  • Table 18 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 148, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • TABLE 18
    yields O.P. R.T.
    S.E. (%) shapes L.C. ESI+ ESI− (min)
    149 67 white solid 8 466/468 464/466 4.90
    150 67 white solid 8 452/454 450/452 4.92
    151 85 pale yellow solid 8 479/481 477/479 4.75
    152 40 pale yellow solid 8 515/517 513/515 4.85
    153 73 white solid 8 528/530 526/528 4.95
    154 59 white solid 8 492/494 490/492 4.68
    155 34 pale yellow solid 2 474/476 472/474 3.83
    156 31 white solid 8 479/481 477/479 4.80
    157 26 white solid 3 491 489 3.12
    158 62 yellow solid 3 490 488 2.82
    159 100 yellow solid 3 527 525 3.19
    160 70 pale green solid 3 492 490 2.95
    161 38 pink solid 3 491 489 3.13
    162 42 yellow solid 2 490/492 488/490 3.45
    163 65 pale yellow solid 2 492/494 490/492 3.65
    164 92 yellow solid 7 523/525 521/523 2.94
    165 14 pale yellow solid
    166 40 pale yellow solid 2 598/600 596/598 4.77
    • Synthetic Example 167 Synthesis of 4-(5-chloro-2-{[(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]-ethylidene}-hydrazino)carbonothioyl]amino}-phenoxy)-butyric acid
  • To a suspension of ethyl 4-(5-chloro-2-{[(2-{1-[4-hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidene}hydrazino)carbonothioyl]amino}-phenoxy)butyrate (74 mg, 0.12 mmol) in ethanol (3.0 mL) was added 1 M aqueous sodium hydroxide (370 μL, 0.37 mmol). After the reaction mixture was stirred at room temperature for 19 hours, 1 M hydrochloric acid (370 μL, 0.37 mmol) was added then the precipitated solid was collected by filtration, washed with chloroform and dried by means of a vacuum pump to give the desired product as a yellow solid (yield 59%).
  • LC/MS: condition 3, retention time 3.60 (min)
  • LC/MS (ESI+) m/z; 570, 572 [M+1]+
  • LC/MS (ESI−) m/z; 568, 570 [M−1]−
    • Synthetic Example 168 Synthesis of 4-(5-chloro-2-{[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-1-methyl-1,1-pyrazol-3-yl]-ethylidene}hydrazino)carbonothioyl]amino}phenoxy)-butyric acid
  • This compound was obtained in the similar manner as described in the reference synthetic example 167.
  • Yield: 50%.
  • Shape: white solid.
  • LC/MS: condition 2, retention time 4.52 (min)
  • LC/MS (ESI+) m/z; 570, 572 [M+1]+
  • LC/MS (ESI−) m/z; 568, 570 [M−1]−
    • Synthetic Examples 169-183
  • Table 19 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 31, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • TABLE 19
    yields O.P. R.T.
    S.E. (%) shapes L.C. ESI+ ESI− (min)
    169 37 white solid 8 499/501 497/499 5.32
    170 79 yellow solid 5 437/439 435/437 5.07
    171 87 pale yellow solid
    172 91 yellow solid 5 406/408 404/406 4.57
    173 33 white solid 8 437/439 435/437 4.78
    174 62 white solid 8 406/408 404/406 4.79
    175 50 white solid 8 420/422 418/420 4.97
    176 51 white solid 5 435/437 433/435 4.29
    177 62 white solid 5 420/422 418/420 5.90
    178 75 white solid 7 522/524 520/522 3.42
    179 89 white solid 5 454/456 452/454 4.47
    180 86 pale yellow solid 3 406 404 3.00
    181 49 yellow solid 8 495/497 493/495 5.08
    182 71 white solid 5 421/423 419/421 4.92
    183 67 pale yellow solid
    184 80 white solid 3 397 395 3.30
    • Synthetic Example 185 Synthesis of 4-{1-[4-acetoxy-5-(4-tert-butylphenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitro benzoic acid 1) Synthesis of acetic acid 4-acetyl-2-(4-tert-butylphenyl) thiophen-3-yl ester
  • To a solution of 2-(4-tert-butylphenyl)-3-hydroxy-4-methylcarbonylthiophene (137 mg, 0.5 mmol) in THF (2 mL) were added triethylamine (105 μL, 0.75 mmol) and acetyl chloride (53.3 μL, 0.75 mmol). The reaction mixture was stirred at room temperature for 0.5 h. After removing solvent, the residue was diluted with AcOEt, washed with a saturated aqueous NH4Cl solution, dried over MgSO4 and concentrated to give product as a brown oil (146 mg, yield 92%).
  • LC/MS: condition 7, retention time 3.25 (min)
  • LC/MS (ESI+) m/z; 317 [M+1]+
    • 2) Synthesis of 4-{1-[4-Acetoxy-5-(4-tert-butylphenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitro benzoic acid
  • To a solution of acetic acid 4-acetyl-2-(4-tert-butylphenyl)thiophen-3-yl ester (63.3 mg, 0.2 mmol) and 4-hydrazinocarbonyl-2-nitrobenzoic acid (54.0 mg, 0.24 mmol) in DMF (1 mL) was added 12 M aqueous HCl solution (16.7 μL, 0.2 mmol). The reaction mixture was stirred overnight, and then water was added. The precipitated solid was collected by filtration and washed with water and CHCl3 to give product as a pale yellow solid (29.1 mg, yield 28%).
  • LC/MS: condition 7, retention time 3.20 (min)
  • LC/MS (ESI+) m/z; 524 [M+1]+
  • LC/MS (ESI−) m/z; 522 [M−1]−
    • Synthetic Example 186 Synthesis of 4-{1-[4-acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid 1) Synthesis of acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester
  • The title compound was prepared from 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (201 mg, 0.7 mmol) following the procedure described in the synthetic example 185.
  • colorless solid (223 mg, yield 97%).
  • LC/MS: condition 7, retention time 3.09 (min)
  • LC/MS (ESI+) m/z; 287, 289 [M−Ac]+
  • LC/MS (ESI−) m/z; 285, 287 [M−Ac]−
    • 2) Synthesis of 4-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidenehydrazinocarbonyl}-2-nitrobenzoic acid
  • The title compound was prepared from acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol) and 4-hydrazinocarbonyl-2-nitrobenzoic acid (40.5 mg, 0.18 mmol) following the procedure described in the synthetic example 185.
  • white solid (17.5 mg, yield 27%).
  • LC/MS: condition 7, retention time 3.07 (min)
  • LC/MS (ESI+) m/z; 536, 538 [M+1]+
  • LC/MS (ESI−) m/z; 534, 536 [M−1]−
    • Synthetic Example 187 Synthesis of 4-(2-{1-[4-Acetoxy-5-(3,4-dichlorophenyl)thiphen-3-yl]ethylidene}hydrazinecarbothioamido)-2-chlorobenzoic acid
  • The title compound was prepared from acetic acid 4-acetyl-2-(3,4-dichlorophenyl)thiophen-3-yl ester (39.5 mg, 0.12 mmol) and 2-chloro-4-(hydrazinecarbothioamido)benzoic acid (40.5 mg, 0.132 mmol) following the procedure described in the synthetic example 185.
  • pale yellow solid (15.1 mg, yield 23%).
  • LC/MS: condition 7, retention time 3.12 (min)
  • LC/MS (ESI+) m/z; 556, 558 [M+1]+
  • LC/MS (ESI−) m/z; 554, 556 [M−1]−
    • Synthetic Examples 188-224
  • Table 20 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 50, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • TABLE 20
    yields O.P. R.T.
    S.E. (%) shapes L.C. ESI+ ESI− (min)
    188 67 pale yellow solid 7 504/506 502/504 3.19
    189 72 pale yellow solid 7 524/526 522/524 3.19
    190 46 white solid 6 436/438 434/436 3.45
    191 44 white solid 6 451/453 449/451 3.77
    192 73 pale yellow solid 9 508/510 506/508 3.42
    193 67 yellow solid 5 456 454 4.02
    194 49 brown solid 5 476/478 474/476 4.17
    195 47 pale brown solid 8 510 508 5.03
    196 44 brown solid 2 530/532 528/530 4.49
    197 31 pale brown solid 2 462 460 4.92
    198 29 pale yellow solid 2 403/405 401/403 4.00
    199 75 white solid 2 435 433 3.57
    200 86 white solid 2 404/406 402/404 3.60
    201 60 pale yellow solid 2 394 392 4.40
    202 42 white solid
    203 88 white solid 2 435/437 433/435 3.62
    204 45 pale brown solid 9 444 442 3.82
    205 65 pale yellow solid 9 464/466 462/464 2.92
    206 53 pale brown solid 9 494/496 492/494 4.14
    207 78 pale yellow solid 3 514/516 512/514 3.63
    208 70 white solid 2 444 442 4.65
    209 97 yellow solid 2 460/462 458/460 4.79
    210 74 brown solid 2 480/482 478/480 4.42
    211 40 pale yellow solid
    212 80 yellow solid 3 454 452 4.25
    213 100 yellow solid 3 474/476 472/474 3.60
    214 99 pale yellow solid 3 366 364 3.34
    215 33 pale yellow solid
    216 40 pale yellow solid
    217 67 yellow solid 8 430/432 428/430 4.78
    218 60 pale yellow solid 8 473/475 471/473 4.92
    219 66 pale yellow solid 8 479/481 477/479 5.10
    220 84 pale yellow solid 8 489/491 487/489 4.78
    221 46 pale yellow solid 8 495/497 493/495 4.82
    222 50 white solid 8 465/467 463/465 5.07
    223 47 white solid 8 481/483 479/481 4.93
    224 57 yellow solid 2 494/496 492/494 4.52
    • Synthetic Example 225 Synthesis of quinoxaline-6-carboxylic acid {1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]-ethylidene}-hydrazide
  • A solution of 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (25 mg, 0.087 mmol) and quinoxaline-6-carboxylic acid hydrazide (25 mg, 0.087 mmol) in dimethylsulfoxide (0.5 mL) was stirred at 100° C. for 12 hours and the reaction mixture was concentrated under the reduced pressure. To the residue was added chloroform and the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 10%).
  • LC/MS: condition 8, retention time 3.77 (min)
  • LC/MS (ESI+) m/z; 457, 459 [M+1]+
  • LC/MS (ESI−) m/z; 455, 457 [M−1]−
    • Synthetic Examples 226-233
  • Table 21 shows the number of the synthetic examples (S.E.) obtained in the similar manner as described in the synthetic example 225, yields, shapes, LC/MS conditions (L.C.), LC/MS observed peaks (O.P.) and retention times (R.T.).
  • TABLE 21
    yields O.P. R.T.
    S.E. (%) shapes L.C. ESI+ ESI− (min)
    226 45 orange solid 5 539/541 537/539 3.70
    227 53 orange solid 5 525/527 523/525 3.63
    228 84 yellow solid 2 462 460 3.74
    229 49 yellow solid 6 480 478 3.54
    230 80 white solid 9 464 3.09
    231 85 yellow solid 3 430/432 428/430 3.50
    232 95 red solid 2 476/478 474/476 4.35
    233 71 pale yellow solid 8 424 422 4.78
    • Synthetic Example 234 Synthesis of 1H-benzoimidazole-5-carboxylic acid {1-[5-(3,4-dichloro-phenyl)-4-hydroxy-thiophen-3-yl]-ethylidene}-hydrazide
  • To a suspension of 1H-benzoimidazole-5-carboxylic acid (24 mg, 0.15 mmol) in toluene (0.5 mL) was added thionyl chloride (11 μL, 0.15 mmol). The reaction mixture was stirred at 100° C. for 1 hour and concentrated under the reduced pressure. To the residue was added a solution of 2-(3,4-dichlorophenyl)-4-(1-hydrorazonoethyl)thiophen-3-ol (30 mg, 0.10 mmol) in dimethylacetamide (0.6 mL) and the reaction mixture was stirred at room temperature for 2 hours. To the reaction mixture was added methanol and water then the precipitated solid was filtrated and dried by means of a vacuum pump to give the desired product as a gray solid (yield 38%).
  • LC/MS: condition 8, retention time 4.27 (min)
  • LC/MS (ESI+) m/z; 445, 447 [M+1]+
  • LC/MS (ESI−) m/z; 443, 445 [M−1]−
    • Synthetic Example 235 Synthesis of N′-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl]ethylidene}-4-methylisoxazole-5-carbohydrazide
  • This compound was obtained in the similar manner as described in the reference synthetic example 234.
  • Yield: 46%.
  • Shape: yellow solid.
  • LC/MS: condition 8, retention time 5.02 (min)
  • LC/MS (ESI+) m/z; 410, 412 [M+1]+
  • LC/MS (ESI−) m/z; 408, 410 [M−1]−
    • Synthetic Example 236 Synthesis of 2-chloro-N′-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]ethylidene}nicotinohydrazide
  • This compound was obtained in the similar manner as described in the reference synthesis example 234.
  • Yield: 50%.
  • Shape: pale yellow solid.
  • LC/MS: condition 8, retention time 5.10 (min)
  • LC/MS (ESI+) m/z; 440, 442 [M+1]+
  • LC/MS (ESI−) m/z; 438, 440 [M−1]−
    • Synthetic Example 237 Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid {1-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]ethylidene}-hydrazide 1) Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid
  • 4-Bromomethyl-3-nitrobenzoic acid (3.00 g, 11.5 mmol) and sodium carbonate (6.12 g, 57.7 mmol) were dissolved in water (40 mL) and acetone (40 mL). The reaction mixture was refluxed for 4 hours and then concentrated under reduced pressure to remove acetone. The residue was washed with diethyl ether three times. The aqueous layer was acidified with 6M hydrochloric acid, and then extracted with ethyl acetate three times. The combined organic layer was washed with water and brine, dried with sodium sulfate, filtered, concentrated under the reduced pressure. The residue was dried by means of a vacuum pump to give the desired product as brown solid (2.17 g, yield 95%).
  • LC/MS: condition 5, retention time 1.59 (min)
  • LC/MS (ESI−) m/z; 196 [M−1]−
    • 2) Synthesis of 4-(tert-butyldimethylsilanyloxymethyl)-3-nitrobenzoic acid
  • To a solution of 4-hydroxymethyl-3-nitrobenzoic acid (1.50 g, 7.62 mmol) and imidazole (1.55 g, 22.8 mmol) in dimethylformamide (20 mL) was added tert-butyldimethyl-silyl chloride (2.23 g, 14.8 mmol), and then the reaction mixture was stirred at room temperature for 15 hours. To the reaction mixture, saturated ammonium chloride aqueous solution was added and acidified with 1 M hydrochloric acid. The aqueous layer was extracted with ethyl acetate three times. The combined organic layer was washed with saturated ammonium chloride aqueous solution, water and brine, dried with sodium sulfate, filtered, and concentrated under the reduced pressure. The residue was purified by silica gel column chromatography to give the desired product as a white solid (1.73 g, yield 73%).
  • LC/MS: condition 5, retention time 5.10 (min)
  • LC/MS (ESI−) m/z; 310 [M−1]−
    • 3) Synthesis of 4-(tert-butyldimethylsilanyloxymethyl)-3-nitrobenzoic acid hydrazide
  • To a solution of 4-(tert-butyl-dimethylsilanyloxy-methyl)-3-nitrobenzoic acid (1.00 g, 3.22 mmol), N,N,N′,N′-tetramethylfluoroformamidinium hexafluoro-phosphate (852 mg, 3.23 mmol) and triethylamine (0.90 mL, 6.44 mmol) in dimethylformamide (13 mL), hydrazine monohydrate (0.31 mL, 6.43 mmol) was added at 0° C., and then the reaction mixture was stirred at 0° C. for 8 hours. To the reaction mixture was added water (10 mL), then the precipitated solid was filtrated and dried by means of a vacuum pump to give the desired product as a pale gray solid (461 mg, yield 44%).
  • LC/MS: condition 5, retention time 4.14 (min)
  • LC/MS (ESI+) m/z; 326 [M+1]+
  • LC/MS (ESI−) m/z; 324 [M−1]−
    • 4) Synthesis of 4-hydroxymethyl-3-nitrobenzoic acid {1-[5-(4-tert-butylphenyl)-4-hydroxythiophen-3-yl]-ethylidene}hydrazide
  • A solution of 2-(4-tert-butylphenyl)-3-hydroxy-4-methyl-carbonylthiophene (27.8 mg, 0.10 mmol), 4-(tert-butyl-dimethylsilanyloxymethyl)-3-nitrobenzoic acid hydrazide (34.9 mg, 0.11 mmol) and p-toluenesulfonic acid monohydrate (5.7 mg, 0.03 mmol) in isopropanol (1.0 mL) was stirred at 95° C. for 7 hours. The precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as yellow solid (34.8 mg, yield 73%).
  • LC/MS: condition 5, retention time 5.53 (min)
  • LC/MS (ESI+) m/z; 468 [M+1]+
  • LC/MS (ESI−) m/z; 466 [M−1]−
    • Synthetic Example 238 Synthesis of N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxy-thiophen-3-yl}ethylidene]-2-oxo-2,3-dihydro-1H-benzo-[d]imidazole-5-carbohydrazide
  • To a suspension of 3,4-diamino-N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]-benzohydrazide (30 mg, 0.064 mmol, see the synthetic example 176) in tetrahydrofuran (3.0 mL) was added sodium tert-butoxide (12 mg, 0.13 mmol) and N,N′-carbonyl diimidazole (15 mg, 0.095 mmol). The reaction mixture turned clear orange and was stirred at room temperature for 16 hours, and then N,N′-carbonyl diimidazole (15 mg, 0.095 mmol) was added. The reaction mixture was stirred further for 12 hours, acidified with 1M aqueous HCl solution (0.7 mL) and concentrated under the reduced pressure. To the residue was added water (4 mL), then the precipitated solid was collected by filtration and dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 97%).
  • 1H-NMR (DMSO-d6) δ (ppm): 2.46 (s, 3H), 7.05 (d, J=8.0 Hz, 1H), 7.51 (s, 1H), 7.57-7.73 (m, 3H), 8.06 (s, 1H), 8.07 (s, 1H), 10.93 (s, 1H), 11.01 (s, 1H), 11.23 (s, 1H), 12.92 (br s, 1H).
    • Synthetic Example 239 Synthesis of N′-[1-{5-(4-cert-butylphenyl)-4-hydroxythiophen-3-yl}ethylidene]-4-(4-methylpiperazine-1-carbonyl)-3-nitrobenzohydrazide
  • To a N-methyl-2-pyrrolidinone (1.0 mL) solution of 2-nitro-4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]-ethylidene}hydrazino)carbonyl]benzoic acid (50 mg, 0.10 mmol, see the synthetic example 47) and triethylamine (16 μL, 0.11 mmol) was added isobutyl chloroformate (26 μL, 0.20 mmol) at 0° C. The reaction mixture was stirred for 2 hours at this temperature, and then N-methyl piperazine (45 μL, 0.40 mmol) was added. After stirring for 1 hour at room temperature, the reaction mixture was acidified with 1M aqueous HCl solution (1.0 mL) and concentrated under the reduced pressure. To the residue was added water, then the precipitate was collected by filtration, washed with water, isopropanol and methanol, then dried by means of a vacuum pump to give the desired product as a pale yellow solid (yield 10%).
  • LC/MS: condition 6, retention time 2.57 (min)
  • LC/MS (ESI+) m/z; 564 [M+1]+
  • LC/MS (ESI−) m/z; 562 [M−1]−
    • Synthetic Example 240 Synthesis of N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]-2-thioxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbohydrazide
  • To a suspension of 3,4-diamino-N′-[1-{5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl}ethylidene]benzohydrazide (30 mg, 0.064 mmol, see the synthetic example 176) in tetrahydrofuran (3.0 mL) was added sodium tert-butoxide (12 mg, 0.13 mmol) and N,N′-thiocarbonyldiimidazole (23 mg, 0.13 mmol). The reaction mixture turned clear orange and was stirred at room temperature for 16 hours, and then was acidified with 1M aqueous HCl solution (1.0 mL) and concentrated under the reduced pressure. The precipitated solid was collected by filtration, washed with chloroform, washed with methanol and dried by means of a vacuum pump to give the desired product as a pale brown solid (yield 52%).
  • 1H-NMR (DMSO-d6) 5(ppm): 2.5 (s, 3H, overlapped by DMSO-d6), 7.26 (d, J=8.3 Hz, 1H), 7.64 (d, J=8.5 Hz, 1H), 7.69 (dd, J=8.5&1.7 Hz, 1H), 7.71 (s, 1H), 7.77 (d, J=8.3 Hz, 1H), 8.06 (d, J=1.7 Hz, 1H), 8.09 (s, 1H) 11:37 (s, 1H), 14.85 (br s, 1H), 14.87 (br s, 1H).
  • The structural formulae of the compounds obtained in the Synthetic Examples are given below.
  • Figure US20140051857A1-20140220-C00043
    Figure US20140051857A1-20140220-C00044
    Figure US20140051857A1-20140220-C00045
    Figure US20140051857A1-20140220-C00046
    Figure US20140051857A1-20140220-C00047
    Figure US20140051857A1-20140220-C00048
    Figure US20140051857A1-20140220-C00049
    Figure US20140051857A1-20140220-C00050
    Figure US20140051857A1-20140220-C00051
    Figure US20140051857A1-20140220-C00052
    Figure US20140051857A1-20140220-C00053
    Figure US20140051857A1-20140220-C00054
    Figure US20140051857A1-20140220-C00055
    Figure US20140051857A1-20140220-C00056
    Figure US20140051857A1-20140220-C00057
    Figure US20140051857A1-20140220-C00058
    Figure US20140051857A1-20140220-C00059
    Figure US20140051857A1-20140220-C00060
    Figure US20140051857A1-20140220-C00061
    Figure US20140051857A1-20140220-C00062
    Figure US20140051857A1-20140220-C00063
    Figure US20140051857A1-20140220-C00064
    Figure US20140051857A1-20140220-C00065
    Figure US20140051857A1-20140220-C00066
    Figure US20140051857A1-20140220-C00067
    Figure US20140051857A1-20140220-C00068
    Figure US20140051857A1-20140220-C00069
    Figure US20140051857A1-20140220-C00070
    Figure US20140051857A1-20140220-C00071
    Figure US20140051857A1-20140220-C00072
    Figure US20140051857A1-20140220-C00073
    Figure US20140051857A1-20140220-C00074
    Figure US20140051857A1-20140220-C00075
    Figure US20140051857A1-20140220-C00076
    Figure US20140051857A1-20140220-C00077
    Figure US20140051857A1-20140220-C00078
    Figure US20140051857A1-20140220-C00079
    Figure US20140051857A1-20140220-C00080
    Figure US20140051857A1-20140220-C00081
    Figure US20140051857A1-20140220-C00082
    Figure US20140051857A1-20140220-C00083
    Figure US20140051857A1-20140220-C00084
    Figure US20140051857A1-20140220-C00085
    Figure US20140051857A1-20140220-C00086
    Figure US20140051857A1-20140220-C00087
    Figure US20140051857A1-20140220-C00088
    Figure US20140051857A1-20140220-C00089
    Figure US20140051857A1-20140220-C00090
    Figure US20140051857A1-20140220-C00091
    Figure US20140051857A1-20140220-C00092
    Figure US20140051857A1-20140220-C00093
    Figure US20140051857A1-20140220-C00094
    • Assay Example 1 Stimulation of Proliferation of a Thrombopoietin (TPO)-Dependent Cell Line (1)
  • The reactivity of the compound of Synthetic Example 3 of the present invention with thrombopoietin (TPO) receptor was assayed using a human leukemic cell line, UT7/EPO-mpl.
    • (1) Cells and Cell Culture
  • UT7/EPO-mpl is a stable transformed cell line obtained by introducing into human leukemic cell line UT7/EPO a vector that induces expression of human TPO receptor (c-mpl) under control of a cytomegaloviral promoter by the method of Takatoku et al. (J. Biol. Chem., 272:7259-7263 (1997)). Proliferation of this cell line is stimulated by TPO, while its mother cell line UT7/EPO exhibits no response to TPO. These two cell lines were subcultured in Iscove's modified Dulbecco's medium (IMDM; GIBCO) containing 10% fetal bovine serum (FES; TRACE SCIENTIFIC, Thermo Electron or BioWest) using a CO2 incubator (5% CO2, 37° C.)
    • (2) Cell Proliferation Assay
  • The subcultured cells described above were washed twice with phosphate buffered saline (PBS) and suspended in IMDM containing 1096 FBS at a cell density of 6×104 cells/ml. The cell suspension was transferred to a 96-well tissue culture plate (CORNING) in 100-μl aliquots. Then either TPO (PeproTech EC) or the compound of Synthetic Example 3 dissolved in dimethyl sulfoxide (DMSO) was diluted 83-fold with IMDM containing 10% FBS and added to the aforementioned cell suspension in 20-μl aliquots. The suspension was incubated in a CO2 incubator (5% CO2, 37° C.) for 4 days. Cell proliferation was assayed using WST-8 reagent (Kishida Chemical Co., Ltd.) according to instructions by the manufacturer. A 10-μl aliquot of 5 mM WST-8 reagent solution was added to each well of the tissue culture plate, and the plate was incubated at 37° C. for 4 h. The formazan pigment generated was detected by measuring the absorbance at 450 nm with a 96-well microplate reader (Nihon Molecular Devices, Spectramax 190). FIG. 1 shows the results with UT7/EPO-mpl cells, while FIG. 2 shows data obtained with UT7/EPO cells expressing no TPO receptor.
    • Assay Example 2 Activity of Signal Transduction Mediated by TPO Receptor
  • The signal-transducing activity of the compound of Synthetic Example 3 of the present invention mediated by TPO receptor was assayed according to the method of Komatsu et al. (Blood, 87:4552-4560 (1996)). Human leukemic cell line UT7/EPO-mpl was washed three times with PBS and suspended in IMDM containing 10% FBS at a cell density of 9×105 cells/ml. The cell suspension was incubated in a CO2 incubator (5% CO2, 37° C.) for 18 h. To 2 ml of this cell suspension (7×106 cells/ml), either TPO (final concentration, 30 ng/ml) or a DMSO solution of the compound of Synthetic Example 3 (final concentration, 1 μg/ml) was added. After incubating the mixture at 37° C. for 1-15 min, the cells were lysed in 1.4 ml of TNE buffer (20 mM Tris-HCl buffer (pH 7.4) containing 150 mM NaCl, 1 mM EDTA, 1% Triton X-100, 1 mM PMSF, 1 mM Na3VO4, and 1/400-diluted Protease Inhibitor Cocktail (SIGMA)). The cell lysate was centrifuged to collect the supernatant for immunoprecipitation with antibodies against proteins involved in signal transduction (anti-STAT3 (SANTA CRUZ BIOTECHNOLOGY) and anti-STAT5A (UPSTATE BIOTECHNOLOGY)) and protein G Sepharose (PHARMACIA). The immunoprecipitated protein fraction was collected and denatured in a sample buffer for separation by SDS-polyacrylamide gel electrophoresis (7.5%). The separated proteins were transferred onto polyvinylidene difluoride (PVDF) membrane (Atto Corporation, 0.2 μm pore size) at 100 V for 1 h for detection of tyrosine phosphorylation using an alkaline phosphatase-labelled antibody against phosphorylated tyrosine (RC20, TRANSDUCTION LABORATORIES). The antigen-antibody complex formed on the PVDF membrane was visualized with 150 μg/ml NET (BIO-RAD) and 300 μg/ml BCIP (BIO-RAD). The results are summarized in Table 22.
  • TABLE 22
    SYNTHETIC
    DMSO EXAMPLE 3 TPO
    STAT
    3 − + +
    STAT 5A − + +
  • FIG. 1 demonstrated that proliferation of TPO responsive UT7/EPO-mpl cells was stimulated by the compound of Synthetic Example 3 in a concentration dependent manner, while no effect of this compound on proliferation was observed with UT7/EPO, the mother cell line, as shown in FIG. 2. These results indicate that the compound of Synthetic Example 3 of the present invention acts on the TPO receptor selectively as an activator.
  • Table 22 shows that the compound of Synthetic Example 3 stimulates phosphorylation of STAT3 and STAT5A is in the same manner as TPO does. The results demonstrate that the compound of the present invention shows agonistic action through the same signal transduction as that caused by TPO.
    • Assay Example 3
  • The compounds of the following Synthetic Examples were tested according to the method of Assay Example 1 to determine the concentration of each compound that yields a growth rate corresponding to 50% of the growth of human leukemic cell line UT-7/EPO-mpl observed in the presence of 10 ng/ml TPO (EC50). The results are summarized in Table 23.
  • TABLE 23
    Synthetic EC50
    Example No. (ng/ml)
    1 3.5
    2 4.5
    3 2.7
    4 10.5
    5 45.0
    6 3.5
    7 3.8
    8 3.7
    9 5.9
    10 21.3
    11 2.9
    13 7.8
    32 4.3
    49 14
    76 5.8
    89 3.2
    97 4.7
    107 3.3
    113 4.7
    124 2.9
    126 3.4
    127 3.5
    136 3.1
    154 2.8
    155 5.3
    157 3.1
    161 3.9
    164 3.0
    167 3.9
    169 3.7
    176 16
    178 3.4
    179 3.0
    181 2.8
    212 0.24
    218 2.2
    221 2.9
    226 2.2
    228 0.72
    235 13
    239 4.2
    240 6.0
    • Assay Example 4 Megakaryocyte Colony Stimulating Activity
  • The action of the compound of Synthetic Example 2 of the present invention on the proliferation, differentiation and maturation of megakaryocyte cells was measured by the megakaryocyte colony forming method using human bone marrow cells. Human bone marrow CD34+ cells (Cambrex Bio Science Walkersville) were incubated on 2-well chamber slide for 11 days in a CO2 incubator (5% CO2, 37° C.) using MegaCult™-C (StemCell Technologies) containing 0.10 (v/v) of the compound of Synthetic Example 2 dissolved in DMSO. After dehydration and fixation, the cells were stained with an anti-glycoprotein IIb/IIIa antibody in accordance with the instruction by the manufacturer. The colonies consisting of at least 8 stained megakaryocyte cells in each well was counted under a microscope. The megakaryocyte colony counts of duplicate or more assays were averaged.
  • The results demonstrate that the compound of the present invention has excellent megakaryocyte colony stimulating activity and increases platelets through the activity.
  • The results are shown in Table 24.
  • TABLE 24
    Synthetic Example 2
    Concentration (μg/ml) 0.3 1
    Megakaryocyte colony 25 48
    Count
    • Formulation Example 1
  • A granule preparation containing the following ingredients is prepared.
  • Ingredients
    Compound represented by the formula (1) 10 mg
    Lactose 700 mg
    Corn Starch 274 mg
    HPC-L 16 mg
    1000 mg
  • A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender. The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated (extrusion granulation, die size 0.5-1 mm) and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh) to obtain a granule preparation.
    • Formulation Example 2
  • A powder preparation for capsulation containing the following ingredients is prepared.
  • Ingredients
    Compound represented by the formula (1) 10 mg
    Lactose 79 mg
    Corn Starch
    10 mg
    Magnesium Stearate
    1 mg
    100 mg
  • A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed with magnesium stearate in a V-type blender. The 10% powder is put in hard capsules No. 5, 100 mg each.
    • Formulation Example 3
  • A granule preparation for capsulation containing the following ingredients is prepared.
  • Ingredients
    Compound represented by the formula (1) 15 mg
    Lactose 90 mg
    Corn Starch 42 mg
    HPC-L 3 mg
    150 mg
  • A compound represented by the formula (1) and lactose are sifted through a 60-mesh sieve. Corn starch is sifted though a 120-mesh sieve. They are mixed in a V-type blender. The powder mixture is kneaded with a low-viscosity hydroxypropylcellulose (HPC-L) aqueous solution, granulated and dried. The resulting dry granules are sifted through a shaking sieve (12/60 mesh). The granules are put in hard capsules No. 4, 150 mg each.
    • Formulation Example 4
  • A tablet preparation containing the following ingredients is prepared.
    • Ingredients
  • Ingredients
    Compound represented by the formula (1) 10 mg
    Lactose 90 mg
    Microcrystalline cellulose 30 mg
    Magnesium Stearate 5 mg
    CMC-Na 15 mg
    150 mg
  • A compound represented by the formula (1), lactose, microcrystalline cellulose and CMC-Na (carboxymethylcellulose sodium salt) are sifted through a 60-mesh sieve and mixed. The powder mixture is mixed with magnesium stearate to give a bulk powder mixture. The powder mixture is compressed directly into 150 mg tablets.
    • FORMULATION EXAMPLE 5
  • An intravenous preparation is prepared as follows.
  •
    Compound represented by the formula (1) 100 mg
    Saturated Fatty Acid Glyceride 1000 ml
  • Solutions having the above-mentioned composition are usually administered to a patient intravenously at a rate of 1 ml per 1 minute.
    • INDUSTRIAL APPLICABILITY
  • The compounds of the present invention which have affinity for thrombopoietin receptor and act as thrombopoietin receptor agonists are useful as preventive, therapeutic and improving agents for diseases against which activation of the thrombopoietin receptor is effective, especially as drugs for hematological disorders accompanied by abnormal platelet count and as drugs for diseases treated or prevented by stimulating differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, and are useful as medicines.

Claims (1)

What is claimed is:
1. A compound represented by the formula (1)
Figure US20140051857A1-20140220-C00095
wherein A is a nitrogen atom or CR4 (wherein R4 is a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted with a C2-6 alkenyl group or a C2-6 alkynyl group), a thiol group (the thiol group may be substituted with a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group), an amino group (the amino group may be substituted with one or two C2-6 alkenyl groups or one or two C2-6 alkynyl groups), a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group, the mono- or di-C1-10 alkylamino group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, C2-14 aryl group and a C2-14 aryloxy group), SO2R5, SOR5 or COR5 (wherein R5 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR6R7 (wherein each of R6 and R7 is independently a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a. C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C2-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14, aryl group and a C2-14 aryloxy group), or R6 and R7 mean, together with each other, —(CH2)m1-E-(CH2)m2— (wherein E is an oxygen atom, a sulfur atom, CR26R27 (wherein each of R26 and R27 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR8 (wherein R8 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m1 and m2 is independently an integer of from 0 to 5 provided that m1+m2 is 3, 4 or 5)))),
B is an oxygen atom, a sulfur atom or NR9 (wherein R9 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or a C2-14 aryloxy group (the C2-14 aryloxy group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)) (provided that when A is a nitrogen atom, B is not NH),
R1 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a halogen atom, a carboxyl group, a nitro group, OCHO, a cyano group, a hydroxyl group, a protected hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkoxycarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), a thiol group and an amino group (the thiol group and the amino group may be optionally substituted with one or two substituents selected from the group consisting of: a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)))),
L1 is a bond, CR10R11 (wherein each of R10 and R11 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR12 (wherein R12 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
X is OR, SR13 or NR14R15 (wherein R13 is a hydrogen atom, a C2-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C2-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), and each of R14 and R15 is independently a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyloxy group, (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkylcarbonyloxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group),
L2 is a bond, CR34R35 (wherein each of R34 and R35 is independently a hydrogen atom or a C1-6 alkyl group (the C1-6 alkyl group may be substituted with one or more halogen atoms)), an oxygen atom, a sulfur atom or NR16 (wherein R16 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-13 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
L3 is a bond, CR17R18 (wherein each of R17 and R18 is independently a hydrogen atom, a C2-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), an oxygen atom, a sulfur atom or NR19 (wherein R19 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
L4 is a bond, CR20R21 (wherein each of R20 and R21 is independently a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-34 aryl group and a C2-14 aryloxy group)), an oxygen atom, a sulfur atom or NR22 (wherein R22 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C2-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)),
Y is an oxygen atom, a sulfur atom or NR23 (wherein R23 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and
R3 is a C2-14 aryl group (the C2-14 aryl group may be substituted with one or more substituents independently represented by —W1(CW2W3)mW4 (wherein W1 is (CR24R25)n (wherein each of R24 and R25 is independently a hydrogen atom or a C1-6 alkyl group, (the C1-6 alkyl group may be substituted with one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36 (wherein R36 is a hydrogen atom, a C1-6 alkyl group, formyl group or a C1-6 alkylcarbonyl group), each of W2 and W3 is independently a hydrogen atom or a C1-3 alkyl group (the C1-3 alkyl group may be substituted with one or more halogen atoms), m is 0, 1, 2 or 3, and W4 is a hydroxyl group, a thiol group, an amino group, a formyl group, a halogen atom, a nitro group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkylcarbonylamino group, a mono- or di-C1-10 alkylamino group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkylcarbonylamino group and the mono- or di-C1-10 alkylamino group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, a amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a thiol group, a phosphonic acid group, a sulfonic acid group, a tetrazole group, a C2-14 aryl group and a C2-14 aryloxy group), SO2R28, SOR28, COR28 (wherein R28 is a hydroxyl group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group and the C1-10 alkoxy group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)), a C2-14 aryl group, a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may is be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group) or NR29R30 (wherein each of R29 and R30 is independently a hydrogen atom, a hydroxyl group, a formyl group, a cyano group, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C1-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group), or R29 and R30, together with each other means —(CH2)m3-G-(CH2)m4— (wherein G is an oxygen atom, a sulfur atom, a CR31R32 (wherein each of R31 and R32 is independently a hydrogen atom, a C1-10 alkyl group, a C2-14 aryl group, a C1-10 alkoxy group, a C2-14 aryloxy group, a hydroxyl group or a protected hydroxyl group) or NR33 (wherein R33 is a hydrogen atom, a hydroxyl group, a formyl group, a C1-10 alkyl group, a C2-6 alkenyl group, C2-6 alkynyl group, a C1-10 alkoxy group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonyl group (the C1-10 alkyl group, the C2-6 alkenyl group, the C2-6 alkynyl group, the C1-10 alkoxy group, the C1-10 alkylcarbonyloxy group, the C2-10 alkoxycarbonyl group and the C1-10 alkylcarbonyl group may be optionally substituted with one or more substituents selected from the group consisting of: a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, C1-10 alkoxycarbonyl group, a C1-10 alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group (the C2-14 aryl group and the C2-14 aryloxy group may be substituted with one or more C1-6 alkyl groups (the C1-6 alkyl group may be substituted with one or more halogen atoms) or one or more halogen atoms)) or a C2-14 aryl group (the C2-14 aryl group may be optionally substituted with one or more substituents selected from the group consisting of: a C1-10 alkyl group (the C1-10 alkyl group may be substituted with one or more halogen atoms), a C2-6 alkenyl group, a C2-6 alkynyl group, a carboxyl group, a nitro group, a cyano group, a halogen atom, a C1-10 alkoxy group, a C1-10 alkylcarbonyl group, a C1-10 alkylcarbonyloxy group, a C1-10 alkoxycarbonyl group, alkylcarbonylamino group, an amino group, a mono- or di-C1-10 alkylamino group, a hydroxyl group, a protected hydroxyl group, a C2-14 aryl group and a C2-14 aryloxy group)), and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5))), a tetrazole group, or a phosphonic acid group)), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
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