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US20110198261A1 - Blister pack - Google Patents

Blister pack Download PDF

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Publication number
US20110198261A1
US20110198261A1 US13/058,058 US200913058058A US2011198261A1 US 20110198261 A1 US20110198261 A1 US 20110198261A1 US 200913058058 A US200913058058 A US 200913058058A US 2011198261 A1 US2011198261 A1 US 2011198261A1
Authority
US
United States
Prior art keywords
film
blister pack
pack according
containers
filling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/058,058
Other languages
English (en)
Inventor
Stephan Kurtze
Stefan Lustenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH reassignment BOEHRINGER INGELHEIM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KURTZE, STEPHAN, LUSTENBERGER, STEFAN
Publication of US20110198261A1 publication Critical patent/US20110198261A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2215/00—Child-proof means
    • B65D2215/02—Child-proof means requiring the combination of simultaneous actions

Definitions

  • the invention relates to a blister pack having a bottom film and a top film for forming a plurality of film containers that can be separated from one another, each having one accommodating chamber for a filling, particularly a pharmaceutical active substance formulation, the accommodating chambers being arranged around the peripheral boundary of the blister pack.
  • the invention further relates to a blister pack having a bottom film and a top film for forming a plurality of film containers that can be separated from one another by means of perforations, each having one accommodating chamber for a filling, particularly a pharmaceutical active substance formulation, the rectangular film containers being arranged in a matrix.
  • Film containers are used, among other things, for protecting pharmaceutical active substance formulations from external environmental effects, which in some circumstances may affect the pharmaceutical quality of the active substance formulation, and generally consist of a top film and a bottom film, with cavities for the filling provided in the bottom film.
  • the top film and the bottom film may be made up of one or more layers of the same or different materials.
  • the top film is attached to the bottom film in sealed manner for example by adhesive bonding, welding or sealing.
  • the top film and/or the bottom film are generally in the form of a metal and/or plastic and/or paper film. These materials may be present in a plurality of layers.
  • Typical metal films include for example aluminium films and composite aluminium films which are made from aluminium and a plastic, for example.
  • the material used for the plastic films may be polyvinylchloride (PVC), cyclo-olefin-copolymer (COC), polychlorotrifluoroethylene (PCFE), polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET), polycarbonate (PC), polyester (UP), polyacrylate, polyamide (PA) or another plastic or a multi-layer composite plastic film, consisting for example of a combination of polychlorotrifluoroethylene (PCTFE), which is known particularly by the brand name Aclar® registered as a trade mark by Honeywell International, Inc., with polyvinylchloride (PVC) or polyvinyl chloride (PVC) with polyvinylidene chloride (PVdC).
  • PCTFE polychlorotrifluoroethylene
  • PVdC polyvinylidene chloride
  • a film container or blister consists of an aluminium top film which seals the bottom film to accommodate the pharmaceutical product or active substance.
  • This thermoformed bottom film may also comprise an aluminium foil to prevent water from entering the cavity for holding the pharmaceutical product.
  • the aluminium foil of the bottom film or the top film may optionally be covered on one or both sides with additional plastic and/or paper films.
  • the problem of the invention is to provide a film container of the type mentioned hereinbefore in which the removal of a filling is determined by the shape of the film container, and which has good childproof properties.
  • the centre of the blister pack is formed by a film section that can be detached and after its removal an opening region is provided for opening the accommodating chamber.
  • perforation denotes both an actual punching through of a material or of a plurality of layers or plies of a material of the blister pack, and a thinning of the material, a bending line, fold line, embossed marking or the like. Perforations of this kind may be produced by machine during the manufacture of the blister pack to enable individual film containers to be torn off or separated.
  • a perforation running in a circle around the film section is expediently associated with the film section.
  • the film containers may be separated into segments.
  • the perforation between the film containers does not extend to the outer periphery of the blister pack.
  • accidental tearing or separation of the film container along the perforations from the edge or periphery of the blister pack is effectively prevented.
  • a user can only detach the film container starting from the centre, to gain access to the according to or to separate the film container from the rest of the blister pack.
  • the film containers are arranged relative to one another with an outer contour in the form of a polygon, circle or oval.
  • the arrangement allows a plurality of film containers to be put together to form a blister pack, each film container only being capable of being opened from the centre.
  • the problem according to the invention is solved, in a blister pack having a bottom film and a top film to form a plurality of film containers that can be separated from one another by means of perforations, each having an accommodating chamber for a filling, particularly a pharmaceutical active substance formulation, the rectangular film containers being arranged to form a matrix, by the fact that the film containers can be separated in a spiral configuration, wherein the perforation is provided in certain areas between pairs of adjacent film containers, and in the region of the perforation, an opening region is provided for removing the filling from the accommodating chamber.
  • the spiral arrangement of the film containers and hence of the accommodating chambers as well determines the sequence of opening or separating the individual accommodating chambers each of which is filled with a pharmaceutical active substance formulation.
  • the film containers have to be separated in a particular sequence that produces a spiral to enable the user to reach the opening region.
  • the spiral shape is ensured for example by corresponding non-perforated regions between the film containers.
  • Only one opening region is provided on each film container.
  • the unusual method of operation provides childproofing, as the method of opening the accommodating chamber is unusual and hence more difficult for a child. An adult, on the other hand, will readily be able to grasp and implement the processes for opening the accommodating chamber.
  • the opening region is constructed as a gripping tab for removing the top film.
  • the top film is not connected to the bottom film over its entire area in the opening region, or is sealed less firmly.
  • the cover film that rests relatively loosely on the bottom film or can be pulled away from the bottom film relatively easily is relatively easily lifted and pulled or torn away from the bottom film by a user, in the opening region, in order to open the accommodating chamber to allow access to the filling in the accommodating chamber.
  • the opening region comprises a notch or a cut as a weakened area of the bottom film and/or the top film.
  • the notch or the cut extends from one edge region of the film container centrally towards the accommodating chamber.
  • the film container can be torn open as far as the accommodating chamber to remove the filling.
  • the blister pack may be marked with corresponding inscriptions or print consisting of numbers, days of the week or the like, to indicate the correct sequence for removing the filling from the accommodating chambers.
  • the bottom film is made of plastics, aluminium or a combination of these materials.
  • the shape, size and number of the various cavities of the accommodating chambers in the bottom film are adapted to the filling that is to be placed therein, such as a tablet or the like, for example.
  • a single blister pack may comprise a plurality of film containers having the corresponding number of accommodating chambers.
  • the bottom film is produced, for example, on the side facing the filling, from a layer of polyvinylchloride (PVC) that is approximately 60 ⁇ m thick, followed by a roughly 45 ⁇ m thick aluminium film, which is in turn attached to a roughly 25 ⁇ m thick film of an oriented polyamide (oPA).
  • PVC polyvinylchloride
  • oPA oriented polyamide
  • the top film is a composite aluminium film, which consists, for example, on the side facing the filling, of an aluminium film roughly 20 ⁇ m thick and attached thereto a film, roughly 23 ⁇ m thick, of a polyethylene terephthalate (PET).
  • PET polyethylene terephthalate
  • the bottom film and the top film may also be identical or made from other materials.
  • FIG. 1 shows a plan view of a blister pack according to the invention
  • FIG. 2 shows a plan view of an alternative film container of the blister pack according to FIG. 1 and
  • FIG. 3 shows a plan view of an alternative embodiment of a blister pack.
  • the blister pack 7 containing a plurality of film containers 1 comprises a bottom film with cavities 8 and a top film, which is attached to the bottom film in suitable manner, preferably using a heat-seal lacquer, to form closed accommodating chambers 2 in the region of the cavities 8 , each for at least one filling, particularly a pharmaceutical active substance formulation.
  • the individual film containers 1 are arranged relative to one another in the form of a polygon and the individual accommodating chambers 2 are located at the peripheral boundary of the blister pack 7 .
  • a film section 4 is arranged in the centre of the blister pack 7 in which there is no accommodating chamber 2 , and which can be detached from the blister pack by means of a substantially circular perforation 3 .
  • Adjoining the film section 4 are defined opening regions 5 for opening the accommodating chambers 2 of the segment-shaped film containers 1 .
  • the individual film containers 1 can be separated from one another by means of perforations 10 which start from the perforation 3 , while the perforations 10 between the film containers 1 do not extend up to the periphery of the blister pack 7 , to ensure that detachment of the film containers 1 from outside is difficult and is easily carried out from the direction of the centre after the film section 4 has been removed.
  • the opening region 5 is constructed as a gripping tab 9 for pulling the top film away from the bottom film, while the top film is not attached to the bottom film over its whole area in the opening region 5 , or is sealed less firmly.
  • a cut 6 is provided in the opening region 5 as a weakened area of the bottom film and top film and thus constitutes a tearing aid which extends centrally from an edge region of the film container 1 facing into the centre of the blister pack 7 in the direction of the accommodating chamber 2 .
  • the user tears open the film container 1 as far as the accommodating chamber 2 .
  • rectangular film containers 1 which can be detached in a spiral configuration are arranged to form a matrix. Between pairs of adjacent film containers 1 there is a perforation 11 in parts and in the region of the perforation 11 the opening region 5 for removing the filling from the accommodating chamber 2 is provided, while the opening region 5 may be configured as explained hereinbefore. In some regions of the blister pack 7 there is no perforation 11 between the film containers 1 to ensure a spiral separation. In the regions without a perforation 11 there may be a weakening of the material of the bottom film and top film to make the film containers 1 more difficult to open but nevertheless to enable them to be opened. To explain the sequence of removal of the individual film containers 1 , the blister pack 7 is printed accordingly with numbers 1 to 30.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
US13/058,058 2008-08-11 2009-07-30 Blister pack Abandoned US20110198261A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08162175 2008-08-11
EP08162175.7 2008-08-11
PCT/EP2009/059906 WO2010018077A1 (de) 2008-08-11 2009-07-30 Blisterverpackung

Publications (1)

Publication Number Publication Date
US20110198261A1 true US20110198261A1 (en) 2011-08-18

Family

ID=41070668

Family Applications (2)

Application Number Title Priority Date Filing Date
US13/058,058 Abandoned US20110198261A1 (en) 2008-08-11 2009-07-30 Blister pack
US13/772,522 Abandoned US20130153460A1 (en) 2008-08-11 2013-02-21 Blister pack

Family Applications After (1)

Application Number Title Priority Date Filing Date
US13/772,522 Abandoned US20130153460A1 (en) 2008-08-11 2013-02-21 Blister pack

Country Status (6)

Country Link
US (2) US20110198261A1 (de)
EP (1) EP2323918B1 (de)
JP (1) JP5314139B2 (de)
AT (1) ATE543743T1 (de)
CA (1) CA2733495A1 (de)
WO (1) WO2010018077A1 (de)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130081968A1 (en) * 2009-12-22 2013-04-04 Boehringer Ingelheim International Gmbh Film container of a blister that cannot be extruded
US20150298879A1 (en) * 2012-11-30 2015-10-22 Unitika Ltd. Packaging material for cold forming and press-through pack formed using same
WO2016077439A3 (en) * 2014-11-11 2016-07-14 Dufour Brian Layered multiple single-dose medication systems and assemblies
US9468584B2 (en) 2014-04-02 2016-10-18 Bemis Company, Inc. Child-resistant packaging
US9962913B2 (en) 2012-12-07 2018-05-08 Bemis Company, Inc. Multilayer film
US10934070B2 (en) 2014-02-11 2021-03-02 Bemis Company, Inc. Anti-scalping pharmaceutical packaging film
EP4110261A4 (de) * 2020-02-24 2024-04-17 Algia Pharma, LLC Schmerzmanagementsystem mit mehreren arzneimitteln

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2547307T3 (pl) 2010-03-18 2015-03-31 Medcomb Holding Aps System do otwierania medycznego opakowania blistrowego

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6230894B1 (en) * 1998-10-22 2001-05-15 Novartis Pharmaceuticals Corp. Child resistant package and method of dispensing medication
US20060131204A1 (en) * 2004-12-21 2006-06-22 Boehringer Ingelheim International Gmbh Film container
US7121410B2 (en) * 2004-06-05 2006-10-17 Romaco Pharmatechnik Gmbh Blister pack
US7293653B2 (en) * 2001-01-23 2007-11-13 Lts Lohmann Therapie-Systeme Ag Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms
US20080289989A1 (en) * 2007-05-22 2008-11-27 Kalvelage John D Sealed blister assembly

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4518131Y1 (de) * 1967-07-20 1970-07-24
JPS5411256Y2 (de) * 1973-12-28 1979-05-22
US5551567A (en) * 1994-04-29 1996-09-03 Mcneil-Ppc, Inc. Blister package containing gripping means
US6036016A (en) * 1998-04-20 2000-03-14 Pinnacle Intellectual Property Services, Inc. Blister package with easy tear blister
US20020045184A1 (en) * 2000-10-02 2002-04-18 Chih-Ming Chen Packaging system
DE20314741U1 (de) * 2003-09-24 2004-01-15 Amthor, Günter Medikament-Kalender
US7395928B2 (en) * 2005-07-14 2008-07-08 Abbott Laboratories Child-resistant blister package
JP3117622U (ja) * 2005-09-22 2006-01-12 健一朗 中島 服用タイミング表示付き周回状ブリスターパック

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6230894B1 (en) * 1998-10-22 2001-05-15 Novartis Pharmaceuticals Corp. Child resistant package and method of dispensing medication
US7293653B2 (en) * 2001-01-23 2007-11-13 Lts Lohmann Therapie-Systeme Ag Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms
US7121410B2 (en) * 2004-06-05 2006-10-17 Romaco Pharmatechnik Gmbh Blister pack
US20060131204A1 (en) * 2004-12-21 2006-06-22 Boehringer Ingelheim International Gmbh Film container
US7866474B2 (en) * 2004-12-21 2011-01-11 Boehringer Ingelheim International Gmbh Film container
US20080289989A1 (en) * 2007-05-22 2008-11-27 Kalvelage John D Sealed blister assembly

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130081968A1 (en) * 2009-12-22 2013-04-04 Boehringer Ingelheim International Gmbh Film container of a blister that cannot be extruded
US20150298879A1 (en) * 2012-11-30 2015-10-22 Unitika Ltd. Packaging material for cold forming and press-through pack formed using same
EP2927153B1 (de) 2012-11-30 2018-11-14 Unitika Ltd. Verpackungsmaterial zum kaltformen und damit geformte durchdrückpackung
US9962913B2 (en) 2012-12-07 2018-05-08 Bemis Company, Inc. Multilayer film
US10934070B2 (en) 2014-02-11 2021-03-02 Bemis Company, Inc. Anti-scalping pharmaceutical packaging film
US12065296B2 (en) 2014-02-11 2024-08-20 Amcor Flexibles North America, Inc. Anti-scalping pharmaceutical packaging film
US9468584B2 (en) 2014-04-02 2016-10-18 Bemis Company, Inc. Child-resistant packaging
WO2016077439A3 (en) * 2014-11-11 2016-07-14 Dufour Brian Layered multiple single-dose medication systems and assemblies
US11229579B2 (en) 2014-11-11 2022-01-25 Brian Dufour Layered multiple single-dose medication systems and assemblies
EP4110261A4 (de) * 2020-02-24 2024-04-17 Algia Pharma, LLC Schmerzmanagementsystem mit mehreren arzneimitteln
US12226376B2 (en) 2020-02-24 2025-02-18 Algia Pharma, Llc Multidrug pain management package

Also Published As

Publication number Publication date
EP2323918A1 (de) 2011-05-25
JP5314139B2 (ja) 2013-10-16
WO2010018077A1 (de) 2010-02-18
US20130153460A1 (en) 2013-06-20
ATE543743T1 (de) 2012-02-15
EP2323918B1 (de) 2012-02-01
JP2011530460A (ja) 2011-12-22
CA2733495A1 (en) 2010-02-18

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Legal Events

Date Code Title Description
AS Assignment

Owner name: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KURTZE, STEPHAN;LUSTENBERGER, STEFAN;REEL/FRAME:026013/0895

Effective date: 20110309

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION