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US20110005943A1 - Wipe Products Having Enhanced Long Term Stability - Google Patents

Wipe Products Having Enhanced Long Term Stability Download PDF

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Publication number
US20110005943A1
US20110005943A1 US12/526,133 US52613308A US2011005943A1 US 20110005943 A1 US20110005943 A1 US 20110005943A1 US 52613308 A US52613308 A US 52613308A US 2011005943 A1 US2011005943 A1 US 2011005943A1
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Prior art keywords
wipe
article
wipes
lotion
package
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US12/526,133
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Thomas W. Beihoffer
Kevin Cureton
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Individual
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/26—Articles or materials wholly enclosed in laminated sheets or wrapper blanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
    • B65D81/22—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient in moist conditions or immersed in liquids

Definitions

  • the present invention relates to wipe products having an enhanced ability to maintain efficacy throughout the shelf life/expiration dating necessary for commercial products. More particularly, the present invention relates to wipes and packaging designs that impart wipe stability in packages containing a plurality of wipes per package.
  • wipes packaging is required to protect the wipes from the environment, and from moisture and volatile material loss, over the life of the wipe.
  • ingredient loss from the package is addressed by overdosing a wet wipe with wipe ingredients, i.e., the wipe lotion, to compensate for ingredient loss during wipe shelf life.
  • This approach is unacceptable for wipes containing a drug because the drug dosage must be constant from wipe to wipe in a multiwipe package over time.
  • Another approach has been to reduce the moisture transport properties (Moisture Vapor Transport Rate; MVTR) of the wipe packaging such that the package better retains volatile ingredients over the product shelf life.
  • MVTR Moipor Transport Rate
  • the present invention is directed to wipes and packaging for a plurality of wipes that in combination help maintain the original constitution of a wipe lotion incorporated into a wipe. More particularly, the present invention relates to wipe lotions incorporated into a wipe substrate and to barrier packaging for a plurality of wipes.
  • the combination of wipe lotion and barrier packaging maintain an essentially constant concentration of volatile and nonvolatile components of the wipe lotion in each wipe throughout the shelf life of the packaged wipes.
  • the plurality of wipes can be packaged under reduced pressure, e.g., a vacuum, or at atmospheric pressure.
  • the improvement provided by the present invention is attained by a wipe and barrier package that promotes and maintains wipe lotion consistency across all wipes in a multiple package during the entire life of the product via a combination of the following:
  • FIG. 1 is a schematic showing a multiwipe package of the present invention.
  • the packaging films typically contain one or more layer of materials designed to have low permeability to water, oxygen, and other liquid and gaseous compounds. These barrier layers reduce the migration or evaporation of critical wipe lotion ingredients from the package during the lifetime of the packaged wipes.
  • the barrier packaging also can reduce the transport of volatile compounds throughout the wipes, i.e., between the individual wipes, that can cause undesirable composition changes by reacting with, or changing the concentration of, an ingredient of the wipe lotion.
  • Wipes that require barrier packaging contain water and/or other volatile ingredients as a component of the wipe lotion. If the vapor barrier of the packaging is insufficient, volatile ingredients transporting through the packaging can cause the wipes to “dry out” over time and before shelf life expiration of the multiwipe package. For an OTC or prescription drug product, water and/or volatile ingredient loss during the shelf life of the multiwipe package can result in an active drug concentration in a wipe that deviates from specifications for the wipe, which can adversely affect drug efficacy or safety and potentially can result in a product recall.
  • Adequate packaging barrier properties also are important for wipe products subjected to extreme conditions over time. Sufficient packaging barrier properties allow a prediction of stability over longer periods of time. Accelerated stability testing is common in cosmetic product development, and guidelines for such testing for drug products are known to persons known in the art are described in the International Conference on Harmonization Q 1 A (R2) Stability Testing of New Drug Substance and Products (February, 2003) (ICH Guidelines).
  • the moisture barrier property of the packaging film for multipack wipe products is less than about 1 gram/100 in 2 /day, for example, less than about each of 0.95, 0.9, 0.85, 0.8, 0.75, 0.7, 0.65, 0.6, 0.55, 0.5, 0.45, 0.4, 0.35, 0.3, 0.25, 0.2, or 0.15 gram/100 in 2 /day, at 25° C., for water vapor.
  • a preferred packaging film moisture barrier property is less than about 0.1, and more preferred less than about 0.05, gram/100 in 2 /day at 25° C. for water vapor.
  • the moisture barrier properties of the label material also is important.
  • the moisture barrier property of the peel/reseal label is less than about 1.5 gram/100 in 2 /day at 25° C., for example, less than about each of 1.45, 1.4, 1.35, 1.3, 1.25, 1.2, or 1.15 gram/100 in 2 /day for water vapor.
  • a preferred water barrier property for a peel/reseal label is less than about 1, and more preferred less than about 0.5, gram/100 in 2 /day at 25° C. for water vapor.
  • Wipes comprise a porous substrate having a wipe lotion impregnated therein.
  • a wipe substrate utilized in the present invention is not limited, and can be any substrate known in the art of wipes.
  • a substrate of a wipe generally is an intersticed material, such as a cloth or fabric-like sheet, comprising fibers or fiber blends designed to impart desired strength and wetting properties to the substrate.
  • a variety of substrate types and constructions are suitable for use in a wipe.
  • suitable substrates include woven and nonwoven webs, such as spun-lace, melt-blown, and air-laid fabrics.
  • Cellulosic fibrous webs are preferred as the porous substrate because of a low cost and biodegradability.
  • Other preferred porous substrates are paper, air-laid, and carded nonwoven webs.
  • Spun-bonded and spun-lace webs also are suitable as the porous substrate.
  • alveolar polymeric films, foam, and other porous substrates can be employed.
  • Nonfibrous substrates such as foams or perforated films
  • the substrate can be in the form of a sheet, pad, or applicator, for example.
  • the substrate can be laminated with other materials, such as other fabrics or films, to achieve a desired form for application of the wipe lotion.
  • the substrate can be wetted with aqueous or nonaqueous liquids, or can be dry, prior to loading with the wipe lotion.
  • Wipe lotions typically are liquids having dissolved and/or suspended ingredients that provide a desired benefit, i.e., contain volatile and nonvolatile ingredients.
  • Wipe lotions can be water-based, oil-based, alcohol-based, or emulsions.
  • Wipe lotions also can contain dispersed solids or microparticle delivery systems to provide a desired benefit.
  • Wipe lotions often contain one or more prescription or OTC drug, in addition to other lotion ingredients.
  • the wipe lotion contains a volatile ingredient that evaporates when the wipe is applied to a target surface, thereby leaving the nonvolatile ingredients of the lotion on the target surface to perform their intended function.
  • a “target surface” is a surface contacted by a wipe to deliver a desired benefit.
  • target surfaces include skin, teeth, and hair for cosmetic and drug applications, and hard surfaces, such as countertops, shower tile, glass, and food contact surfaces, for cleaning applications.
  • a sunscreen wipe is applied to the skin to transfer sunscreen actives to the skin. After the volatile ingredients evaporate, the nonvolatile sunscreen actives remain on the skin to impart UV protection to the skin.
  • Volatile ingredients include, but are not limited to, water; an alcohol, and typically a C 1 , C 2 , C 3 , or C 4 alcohol; a volatile silicone, typically a volatile dimethicone or volatile cyclomethicone; a volatile organic solvent, typically a hydrocarbon, a ketone, or an ester, such as acetone, methyl ethyl ketone, ethyl acetate, methyl acetate, isopropyl acetate, an isoparaffin, methylene chloride, mineral spirits, pentane, toluene, or xylene; or any mixture of such volatile ingredients.
  • a volatile silicone typically a volatile dimethicone or volatile cyclomethicone
  • a volatile organic solvent typically a hydrocarbon, a ketone, or an ester, such as acetone, methyl ethyl ketone, ethyl acetate, methyl acetate, isopropyl acetate, an
  • Wipe lotion rheology is important for a multipack wipe product to maintain a consistent lotion content in each wipe within the package.
  • One failure mode for wipe products is gravity settling of the lotion to the bottom of the package during storage. This results in wipes at the bottom of the package being overloaded with lotion, and accordingly, active agents, while wipes at the top of the package are depleted of lotion, e.g., depleted of active agents. Settling of the lotion can lead to individual wipes within the package failing to meet specifications with respect to active agent content.
  • any lotion-compatible, rheology-modifying compound can be incorporated into the wipe lotion in a amount sufficient to provide a rheology that prevents lotion settling due to gravity.
  • Another method of maintaining an essentially constant concentration of active agent, e.g., a drug, in each wipe of a multiwipe package is to incorporate the active agent into a microparticle delivery system.
  • the microparticle delivery system is dispersed in the wipe lotion, as opposed to dissolved in the wipe lotion. Accordingly, even if the active agent is volatile, evaporation of the active agent from the microparticle delivery system, and accordingly, the wipe, is substantially reduced or eliminated.
  • the microparticle delivery system is dispersed, as opposed to dissolved, in the wipe lotion, the microparticle delivery system resists settling from a wipe due to gravity.
  • the microparticle delivery system, and any active agent loaded thereon has a tendency to remain within the wipe substrate rather than separating from the substrate. The amount of active agent present in the wipe therefore remains essentially constant.
  • each wipe in a multiwipe package contains at least 90% and no more than 110%, by weight, of an active agent, non-active agent, or wipe lotion initially incorporated into the wipe.
  • each wipe contains at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, or at least 98%, of the active agent, non-active agent, or wipe lotion initially incorporated into the wipe.
  • each wipe contains no more than 109%, no more than 108%, no more than 107%, no more than 106%, no more than 105%, no more than 104%, no more than 103%, or no more than 102%, by weight of the active agent, non-active agent, or wipe lotion incorporated into the wipe.
  • an active agent first is loaded onto a microparticle delivery system, then the loaded microparticle delivery system is incorporated into the wipe lotion.
  • An active agent is incorporated, i.e., loaded, onto the polymeric microparticles by spraying or adding the active agent directly to the microparticles in a manner such that an essentially homogeneous distribution of the active agent is achieved on and/or through the microparticles.
  • the active agent is a solid
  • the active agent can be dissolved in a suitable volatile solvent.
  • the resulting solution is added to the microparticles, then the volatile solvent is removed, for example, under vacuum with gentle heating.
  • Another method of loading of a solid active agent that is insufficiently soluble in an appropriate volatile solvent is to disperse the solid active agent in a suitable carrier, such as a polyol, then adding the dispersion directly to the microparticle delivery system.
  • Polymeric microparticle delivery systems comprise discrete, free-flowing particles which can absorb, adsorb, entrap, or otherwise retain an active agent in a polymeric matrix. Such microparticles can provide a controlled release of the active agent over time either by rupture of the microparticle, whereby the active agent is released when sufficient pressure or shearing action is applied to the microparticle, or the microparticle may be semipermeable or porous which allows the active agent to diffuse from the particle.
  • the polymeric microparticles themselves, without a loaded active agent provide a desired benefit, i.e., an oil absorption function. Additionally, the microparticle delivery system can deliver multiple active agents in addition to itself.
  • polymeric microparticle delivery system encompasses microparticles and microcapsules generally, which are a well-known form of polymeric beads formed by emulsion polymerization, precipitation polymerization, and other methods.
  • Absorbent polymeric microparticles have an ability to absorb several times their weight of a liquid compound, such as a skin care compound.
  • adsorbent polymeric microparticles useful as a delivery system is prepared by a suspension polymerization technique, as set forth in U.S. Pat. Nos. 5,677,407; 5,712,358; 5,777,054; 5,830,967; and 5,834,577, each incorporated herein by reference.
  • Such an absorbent polymer is sold under the tradename of POLY-PORE® E200 (INCI name: allyl methacrylate copolymer) available from AMCOL International Corporation, Arlington Heights, Ill.
  • adsorbent microparticles useful as a delivery system is prepared by a precipitation polymerization technique, as set forth in U.S. Pat. Nos. 5,830,960; 5,837,790, 6,248,849; and 6,387,995, each incorporated herein by reference.
  • Such an adsorbent polymer is sold under the tradename POLYTRAP® 7603 also available from AMCOL International Corp.
  • adsorbent microparticles also can be modified after incorporation of an active agent to modify the rate of release of the active agent, as set forth in U.S. Pat. No. 6,491,953, incorporated herein by reference.
  • adsorbent polymers include, for example, MICROSPONGE® (a copolymer of methyl methacrylate and ethylene glycol dimethacrylate), available from AMCOL International Corp., and Poly-HIPE polymers (e.g., a copolymer of 2-ethylhexyl acrylate, styrene, and divinylbenzene) available from Biopore Corporation, Mountain View, Calif.
  • MICROSPONGE® a copolymer of methyl methacrylate and ethylene glycol dimethacrylate
  • Poly-HIPE polymers e.g., a copolymer of 2-ethylhexyl acrylate, styrene, and divinylbenzene
  • the adsorbent polymer microparticles prepared by the suspension polymerization technique are a highly porous and highly crosslinked polymer in the form of open (i.e., broken) spheres and sphere sections characterized by a mean unit particle size of about 0.5 to about 3,000 microns, preferably about 0.5 to about 300 microns, more preferably about 0.5 to about 100 microns, and most preferably about 0.5 to about 80 microns. A significant portion of the spheres is about 20 microns in diameter.
  • the polymeric microparticles are oil and water adsorbent, and have an extremely low bulk density of about 0.008 gm/cc to about 0.1 gm/cc, preferably about 0.009 gm/cc to about 0.07 gm/cc, and more preferably about 0.0095 gm/cc to about 0.04-0.05 gm/cc.
  • the microparticles are capable of holding and releasing oleophilic (i.e., oil soluble or dispersible), as well as hydrophilic (i.e., water soluble or dispersible), active agents, individually, or both oleophilic and hydrophilic compounds simultaneously.
  • Adsorbent polymer microparticles prepared by the suspension polymerization technique include at least two polyunsaturated monomers, preferably allyl methacrylate and an ethylene glycol dimethacrylate, and, optionally, monounsaturated monomers.
  • the microparticles are characterized by being open to their interior, due either to particle fracture upon removal of a porogen after polymerization or to subsequent milling.
  • the microparticles have a mean unit diameter of less than about 50 microns, preferably less than about 25 microns, and have a total adsorption capacity for organic liquids, e.g., mineral oil, that is at least about 72% by weight, preferably at least about 93% by weight, and an adsorption capacity for hydrophilic compounds and aqueous solutions of about 70% to about 89% by weight, preferably about 75% to about 89% by weight, calculated as weight of material adsorbed divided by total weight of material adsorbed plus dry weight of polymer.
  • the broken sphere microparticles are characterized by a mean unit diameter of about 1 to about 50 microns, more preferably of about 1 to about 25 microns, most preferably, of about 1 to about 20 microns.
  • Preferred polymeric microparticle delivery systems comprise a copolymer of allyl methacrylate and ethylene glycol dimethacrylate, a copolymer of ethylene glycol dimethacrylate and lauryl methacrylate, a copolymer of methyl methacrylate and ethylene glycol dimethacrylate, a copolymer of 2-ethylhexyl acrylate, styrene, and divinylbenzene, and mixtures thereof.
  • Specific polymeric microparticles useful in the present invention can be the previously described POLY-PORE® E200, POLYTRAP® 7603, POLYTRAP® 6603, MICROSPONGE®, or Poly-HIPE particles, for example.
  • An active agent is loaded onto such microparticles to provide microparticles containing about 10% to about 90%, preferably about 20% to about 80%, by weight, of the active agent.
  • the active agent-loaded microparticles typically are incorporated into a wipe lotion in an amount to provide about 0.05% to about 10%, by weight, of an active agent in the composition.
  • the active agent is incorporated, or loaded, onto or into the microparticles.
  • the term “loaded microparticle” refers to a microparticle having an active agent added thereto. Loading of the active ingredient includes one or more of impregnating, imbedding, entrapping, absorbing, and adsorbing of the active ingredient into or onto the polymeric microparticles. Loading of the active agent also can be referred to as an “entrapment.” The term entrapment refers to a physical loading of the active ingredient onto the microparticles.
  • Loading can be accomplished by spraying or adding the active agent directly to the microparticles in a manner such that a homogeneous distribution of the active agent on the microparticles is achieved.
  • the active agent first can be dissolved in a suitable solvent, then the resulting solution is sprayed or added to the microparticles. The solvent then is removed by heating, vacuum, or both.
  • active agents can be loaded onto polymeric microparticles, and thereby included in a wipe of the present invention. These same active agents also can be incorporated into a wipe lotion in the absence of polymeric microparticles.
  • active agents include, but are not limited to anti-acne agents, such as salicylic acid, benzoyl peroxide, sulfur, retinoic acid, and resorcinol; and skin-treatment agents, such as retinol, retinol palmitate, retinol acetate, dimethicone, petrolatum, hydroquinone, arbutin, ascorbic acid and derivatives thereof, tocopherol and derivatives thereof, dihydroxyacetone, and L-erythrulose.
  • anti-acne agents such as salicylic acid, benzoyl peroxide, sulfur, retinoic acid, and resorcinol
  • skin-treatment agents such as retinol, retinol palmitate, retinol acetate, dim
  • the active agent can be one of, or a mixture of, a cosmetic compound, a medicinally-active compound, or any other compound that is useful upon topical application to the skin.
  • active agents include, but are not limited to, skin-care compounds, antioxidants, antibacterial compounds, antifungal compounds, anti-inflammatory compounds, topical anesthetics, sunscreens, insect repellants, skincare compounds, plant extracts, antioxidants, counterirritants, vitamins, steroids, and other cosmetic and medicinal topically effective compounds.
  • agents such as benzophenone-3, trihydroxycinnamic acid and salts, tannic acid, uric acids, quinine salts, dihydroxy naphtholic acid, an anthranilate, diethanolamine methoxycinnamate, p-aminobenzoic acid, phenylbenzimidazole sulfonic acid, PEG-25, p-aminobenzoic acid, or triethanolamine salicylate can be used as the active agent.
  • sunscreen compounds such as doxybenzone, ethyl 4-[bis(hydroxypropyl)] amino-benzoate, glyceryl aminobenzoate, homosalate, methyl anthranilate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, red petrolatum, titanium dioxide, 4-menthyl-benzylidene camphor, benzophenone-1, benzophenone-2, benzophenone-6, benzophenone-12, isopropyl dibenzoyl methane, butyl methoxydibenzoylmethane, zotocrylene, zinc oxide, and mixtures thereof, can be used as the active agent.
  • sunscreen compounds such as doxybenzone, ethyl 4-[bis(hydroxypropyl)] amino-benzoate, glyceryl aminobenzoate, homosalate, methyl anthranilate, o
  • topically active drugs like antifungal compounds, antibacterial compounds, antiinflammatory compounds, topical anesthetics, skin rash, skin disease, and dermatitis medications, and anti-itch and irritation-reducing compounds can be used as the active agent in the stick compositions of the present invention.
  • analgesics such as benzocaine, dyclonine hydrochloride, aloe vera, and the like; anesthetics such as butamben picrate, lidocaine hydrochloride, xylocalne, and the like; antibacterials and antiseptics, such as povidoneiodine, polymyxin b sulfate-bacitracin, zinc-neomycin sulfate-hydrocortisone, chloramphenicol, ethylbenzethonium chloride, erythromycin, and the like; antiparasitics, such as lindane; essentially all dermatologicals, like acne preparations, such as benzoyl peroxide, erythromycin benzoyl peroxide, clindamycin phosphate, 5,7-dichloro-8-hydroxyquinoline, and the like; anti-inflammatory agents, such as alclometasone dipropionate, beta-methasone valerate, and the like
  • any other medication capable of topical administration like skin bleaching agents, skin protectants, such as allantoin, and anti-acne agents, such as salicylic acid, also can be incorporated into a wipe lotion in an amount sufficient to perform its intended function.
  • skin protectants such as allantoin
  • anti-acne agents such as salicylic acid
  • Other topically active compounds are listed in Remington's Pharmaceutical Sciences, 17th Ed., Merck Publishing Co., Easton, Pa. (1985), pages 773-791 and pages 1054-1058 (hereinafter Remington 's), incorporated herein by reference.
  • a skin conditioner can be the active agent of the wipe lotion.
  • Skin conditioning agents include, but are not limited to, humectants, such a fructose, glucose, glycerin, propylene glycol, glycereth-26, mannitol, pyrrolidone carboxylic acid, hydrolyzed lecithin, coco-betaine, cysteine hydrochloride, glucamine, sodium gluconate, potassium aspartate, oleyl betaine, thiamine hydrochloride, sodium laureth sulfate, sodium hyaluronate, hydrolyzed proteins, hydrolyzed keratin, amino acids, amine oxides, water-soluble derivatives of vitamins A, E, and D, amino-functional silicones, ethoxylated glycerin, alpha-hydroxy acids and salts thereof, fatty oil derivatives, such as PEG-24 hydrogenated lanolin, beta-hydroxy acids and salts thereof (e.g., glycolic acid,
  • CTFA Cosmetic Ingredient Handbook Eleventh Ed., T. Gottschalck et al., ed., The Cosmetic, Toiletry and Fragrance Association (2006), (hereafter CTFA Handbook), pages 2823-2850, incorporated herein by reference.
  • the skin conditioner also can be a water-insoluble ester having at least 10 carbon atoms, and preferably 10 to about 32 carbon atoms.
  • Suitable esters include those comprising an aliphatic alcohol having about eight to about twenty carbon atoms and an aliphatic or aromatic carboxylic acid having from two to about twelve carbon atoms, or conversely, an aliphatic alcohol having two to about twelve carbon atoms with an aliphatic or aromatic carboxylic acid having about eight to about twenty carbon atoms.
  • the ester is either straight-chained or branched. Suitable esters include, for example, but are not limited to:
  • aliphatic monohydric alcohol esters including, but not limited to: myristyl propionate, isopropyl isostearate, isopropyl myristate, isopropyl palmitate, cetyl acetate, cetyl propionate, cetyl stearate, isodecyl neopentanoate, cetyl octanoate, isocetyl stearate;
  • aliphatic di- and tri-esters of polycarboxylic acid including, but not limited to: diisopropyl adipate, diisostearyl fumarate, dioctyl adipate, and triisostearyl citrate;
  • aliphatic polyhydric alcohol esters including, but not limited to, propylene glycol dipelargonate
  • esters of aromatic acids including, but not limited to: C 12 -C 15 alcohol esters of benzoic acid, octyl salicylate, sucrose benzoate, and dioctyl phthalate. Numerous other esters are listed in the CTFA Handbook, at pages 2679 through 2688, incorporated herein by reference.
  • the topically-active agent also can be a plant extract or a natural oil.
  • Nonlimiting plant extracts are those obtained from alfalfa, aloe vera, amla fruit, angelica root, anise seed, apple, apricot, artichoke leaf, asparagus root, banana, barberry, barley sprout, bee pollen, beet leaf, bilberry fruit, birch leaf, bitter melon, black currant leaf, black pepper, black walnut, blueberry, blackberry, burdock, carrot, cayenne, celery seed, cherry, chickwood, cola nut, corn silk, cranberry, dandelion root, elderberry, eucalyptus leaf, flax oil powder, ginger root, gingko leaf, ginseng, goldenrod, goldenseal, grape, grapefruit, guava, hibiscus, juniper, kiwi, kudzu, lemon, licorice root, lime, malt, marigold, myrrh, olive leaf, orange
  • ingredients also can be incorporated into the wipe lotion and/or the polymeric microparticles.
  • These ingredients include, but are not limited to, dyes, fragrances, preservatives, antioxidants, and similar types of compounds. These ingredients are included in an amount sufficient to perform their intended function, without adversely affecting the efficacy of an active agent present in the wipe lotion. It also is important that the concentration of such non-active agents remain essentially constant in each wipe in order to maintain the esthetics, and consumer acceptance, of the wipe.
  • An important aspect of the present invention is the configuration of the barrier packaging over the stack of wipes. It has been discovered that the configuration of the barrier packaging is critical to maintaining a multiwipe product having an essentially consistant lotion loading in each wipe in the package, especially during storage. Package configuration also contributes to maintaining a consistent balance between volatile and nonvolatile components of the wipe lotion within a wipe, and maintaining the desired or required concentration of wipe lotion components in each wipe.
  • flow wrap packaging is common in the industry to package a variety of wipe products.
  • flow wrap packaging film is formed around a stack of wipes after the wipes have been dosed with the wipe lotion.
  • the packaging is expected to maintain the wipe lotion within the package, thereby preventing ingredient loss via evaporation or leakage from the stack of wipes.
  • the packaging configuration typically is designed to allow a rapid and economical packaging of a wipe stack while avoiding the problem of a wipe being trapped or pinched in areas of the film that are heat sealed.
  • the volume of the package typically is significantly larger than the volume of the packaged wipe stack, e.g., typically about three times the volume of the stack of wipes.
  • the relationship between the wipe stack size and the wrap package dimensions are as follows ( FIG. 1 ):
  • Wipe stack width circumference is the measure of the circumference around the width of the wipe stack, as measured by a flexible tape measure.
  • Wipe stack length circumference is the measure of the circumference around the length of the wipe stack, as measured by a flexible tape measure.
  • PLC Package length circumference
  • Package width circumference is the length of the packaging film surrounding the wipe stack in the width direction (W), neglecting the sealed film areas.
  • the width circumference ratio is 100(PWC-WWC)/WWC.
  • the length circumference ratio is 100(PLC-WLC)/WLC.
  • FIG. 1 illustrates a barrier packaging film for a stack of wipes.
  • FIG. 1 illustrates the back of packaging film 10 for a stack of wipes, wherein the film is wrapped around a stack of wipes (not shown) and sealed along a seam line 12 via a fin seal 16 .
  • the sealed package also is heat sealed at each end, denoted by heat seals 14 .
  • the length of the packaging is denoted by the letter L, and is the measure of the package along seam 12 .
  • the width of the packaging is denoted by the letter W, and is the measure of the package perpendicular to seam line 12 .
  • wipe packages having a comparative configuration is described as follows.
  • the wipe packages contained 10 sunscreen wipes sealed in flow wrap packaging with a peel/reseal label.
  • the wipes were machine prepared individually by dosing a sunscreen lotion on each 8 ⁇ 8 inch substrate to a controlled amount.
  • the wipes then were folded individually, assembled into a stack of 10 wipes, and packaged into flow wrap packages on a semi-automatic packaging machine.
  • the packaging dimension relationships for the comparative packages (Packs 9 - 12 ) are summarized in Table IV.
  • the packages then were placed in a controlled environmental chamber at 45° C. for 93 days to simulate long term in storage of the wipe package at room temperature.
  • the wipe packages were oriented in the chamber with the peel/reseal label facing up and the wipes in the stack oriented horizontally allowing the wipes to be identified by their position in the wipe stack. After the prescribed time period, each package was removed from the chamber, and the wipes were removed from the package and weighed.
  • the packages showed no indication of wipe lotion settling due to gravity because no free lotion was observed in the packaging. Evidence of moisture condensation occasionally was observed in some of the packages as tiny drops of water on the internal surfaces of the packaging film. The results of the experiment are summarized in Table I.
  • a multiple package of the present invention can be prepared at atmospheric pressure or at a reduced pressure, e.g., under a vacuum.
  • atmospheric pressure is the pressure exerted by the atmosphere alone at the temperature of manufacture for the multiwipe packet, i.e., without an application of additional pressure or a reduction in atmospheric pressure.
  • a vacuum or “at reduced pressure” means any pressure that is less than atmospheric pressure at the temperature of manufacture for the multiwipe packet.
  • sunscreen wipes were prepared and packaged in flow wrap film under vacuum to reduce the headspace in the package to essentially zero.
  • the packages then were placed in an environmental chamber at 50° C. for 14 days to simulate a long teen storage of the wipes packages at room temperature.
  • the packages were removed from the chamber, opened, and the wipes were weighed. This weight was compared to their initial weights.
  • Table III The data from this example is summarized in Table III.
  • Table III shows that when the headspace is reduced to essentially zero, the migration of volatiles in the wipe stack also is greatly reduced. Because the elimination of headspace in flow wrap packaging is difficult to achieve in practice, an experiment was performed to determine the effect of headspace reduction on improvement in wipe stability, as measured by a reduction in volatiles migration.
  • a wipe package was prepared (i.e., AMCOL HBS SPF 30 Sunscreen wipes) using production converting and packaging equipment.
  • the relationship between the wipe stack dimensions and the packaging film dimensions is summarized in Table IV.
  • the wipes package was placed in a controlled environment chamber for 3 months at 45° C. to simulate extended storage at room temperature.
  • the wipes package then was removed from the chamber, opened, and the wipes in the stack were weighed to determine the effect of volatiles migration on the wipe weights.
  • the results are summarized in Table V. The results show that moisture migration is greatly reduced compared to the comparative samples in Tables I and II.
  • the multiwipe packages of the present invention have several practical end uses, including hand cleansers, surgical scrubs, body splashes, antiseptics, disinfectants, hand sanitizer gels, and similar personal care products.
  • the wipes further can be used on inanimate surfaces, for example, sinks and countertops in hospitals, cruise ships, nursing homes, food service areas, and meat processing plants.
  • the wipes can be designed as lotions; makeup preparations, like makeup foundations; skin care preparations, like hand lotions, vanishing creams, night creams, sunscreens, body lotions, facial creams, clay masks, moisturizing lotions, makeup removers, antiacne preparations, antiaging preparations, and sebum control preparations; analgesic and cortisonal steroid creams and preparations; insect repellants; and facial masks and revitalizers.
  • the wipes also can be useful to treat hard surfaces.
  • the treat “hard” refers to surfaces comprising refractory materials, such as glazed and unglazed tile, brick, porcelain, ceramics, metals, glass, and the like, and also includes wood and hard plastics such as formica, polystyrenes, vinyls, acrylics, polyesters, and the like. Such surfaces are found, for example, in kitchens and bathrooms.
  • a hard surface can be porous or nonporous.
  • the wipes also can be used to treat hard surfaces in processing facilities (such as dairy, brewing, and food processing facilities), healthcare facilities (such as hospitals, clinics, surgical centers, dental offices, and laboratories), long-term healthcare facilities (such as nursing homes), farms, cruise ships, schools, and private homes.
  • processing facilities such as dairy, brewing, and food processing facilities
  • healthcare facilities such as hospitals, clinics, surgical centers, dental offices, and laboratories
  • long-term healthcare facilities such as nursing homes
  • farms cruise ships, schools, and private homes.
  • the wipes can be used to treat environmental surfaces such as floors, walls, ceilings, and drains.
  • the article can be used to treat equipment such as food processing equipment, dairy processing equipment, brewery equipment, and the like.
  • the wipes can be used to treat a variety of surfaces including food contact surfaces in food, dairy, and brewing facilities, countertops, furniture, sinks, and the like.
  • the wipes further can be used to treat tools and instruments, such as medical tools and instruments, dental tools and instruments, as well as equipment used in the healthcare industries and institutional kitchens, including knives, wares (such as pots, pans, and dishes), cutting equipment, and the like.
  • Methods of treating hard surfaces are described in U.S. Pat. Nos. 5,200,189; 5,314,687; and 5,718,910, the disclosures of which are incorporated herein by reference in their entirety.
  • Treatable inanimate surfaces include, but are not limited to, exposed environmental surfaces, such as tables, floors, walls; kitchenwares, including pots, pans, knives, forks, spoons, and plates; food cooking and preparation surfaces, including dishes; food preparation equipment; and tanks, vats, lines, pumps, hoses, and other process equipment.
  • dairy processing equipment which is commonly made from glass or stainless steel. Such equipment can be found both in dairy farm installations and in dairy plant installations for the processing of milk, cheese, ice cream, and other dairy products.
  • the wipes also can be used to treat medical carts, medical cages, and other medical instruments, devices, and equipment. Examples of medical apparatus treatable by the present wipes are disclosed in U.S. Pat. No. 6,632,291, incorporated herein by reference.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Cosmetics (AREA)
  • Packages (AREA)
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PCT/US2008/053289 WO2008098111A2 (fr) 2007-02-08 2008-02-07 Lingettes ayant une stabilité améliorée à long terme

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Cited By (8)

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US20120141567A1 (en) * 2010-12-07 2012-06-07 Kimberly-Clark Worldwide, Inc. Melt Processed Antimicrobial Composition
US20130270150A1 (en) * 2010-06-22 2013-10-17 Paper Shower, Llc Single-Use-Body Washing System
US20140154338A1 (en) * 2012-11-30 2014-06-05 Zuri Murrell Skin cream
WO2014123771A3 (fr) * 2013-02-08 2014-10-16 The Procter & Gamble Company Trousse pour gonfler un article de nettoyage
US10349790B2 (en) 2014-01-31 2019-07-16 Kimberly-Clark Worldwide, Inc. Refillable, flexible dispenser with handle for stacked moist wipes
USD892614S1 (en) 2018-06-11 2020-08-11 Ecolab Usa Inc. Cap for container
WO2020176305A1 (fr) 2019-02-27 2020-09-03 Medline Industries, Inc. Emballage pour lingettes antiseptiques et chauffage de lingettes emballées
US20240268429A1 (en) * 2023-02-10 2024-08-15 Aaron D. Shapiro Oil impregnated substrate

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US10568907B1 (en) * 2018-10-09 2020-02-25 Carol J. Buck Methods of treating basal cell carcinoma and glioblastoma

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US4651874A (en) * 1979-12-03 1987-03-24 Kenji Nakamura Re-sealable dispenser container
US4775582A (en) * 1986-08-15 1988-10-04 Kimberly-Clark Corporation Uniformly moist wipes
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US5531325A (en) * 1992-03-13 1996-07-02 The Procter & Gamble Company Storing and dispensing system for products packed in a sealed pouch
US5871762A (en) * 1996-10-07 1999-02-16 The Procter & Gamble Company Cosmetic applicators which contain stable oil-in-water emulsions
US20050196480A1 (en) * 2004-03-04 2005-09-08 Michael Sullivan Skin treatment method with lactobacillus extract

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130270150A1 (en) * 2010-06-22 2013-10-17 Paper Shower, Llc Single-Use-Body Washing System
US20120141567A1 (en) * 2010-12-07 2012-06-07 Kimberly-Clark Worldwide, Inc. Melt Processed Antimicrobial Composition
US9832993B2 (en) * 2010-12-07 2017-12-05 Kimberly-Clark Worldwide, Inc. Melt processed antimicrobial composition
US20140154338A1 (en) * 2012-11-30 2014-06-05 Zuri Murrell Skin cream
US8936814B2 (en) * 2012-11-30 2015-01-20 Zuri A. Murrell Skin cream
WO2014123771A3 (fr) * 2013-02-08 2014-10-16 The Procter & Gamble Company Trousse pour gonfler un article de nettoyage
US10349790B2 (en) 2014-01-31 2019-07-16 Kimberly-Clark Worldwide, Inc. Refillable, flexible dispenser with handle for stacked moist wipes
USD892614S1 (en) 2018-06-11 2020-08-11 Ecolab Usa Inc. Cap for container
USD903504S1 (en) 2018-06-11 2020-12-01 Ecolab Usa Inc. Pouch container
WO2020176305A1 (fr) 2019-02-27 2020-09-03 Medline Industries, Inc. Emballage pour lingettes antiseptiques et chauffage de lingettes emballées
EP3931124A4 (fr) * 2019-02-27 2022-11-16 Medline Industries, Inc. Emballage pour lingettes antiseptiques et chauffage de lingettes emballées
US20240268429A1 (en) * 2023-02-10 2024-08-15 Aaron D. Shapiro Oil impregnated substrate

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WO2008098111A3 (fr) 2008-12-31

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