[go: up one dir, main page]

US20100136082A1 - In situ system for intra-articular chondral and osseous tissue repair - Google Patents

In situ system for intra-articular chondral and osseous tissue repair Download PDF

Info

Publication number
US20100136082A1
US20100136082A1 US12/520,850 US52085007A US2010136082A1 US 20100136082 A1 US20100136082 A1 US 20100136082A1 US 52085007 A US52085007 A US 52085007A US 2010136082 A1 US2010136082 A1 US 2010136082A1
Authority
US
United States
Prior art keywords
cartilage
repair patch
wound site
cartilage repair
stem cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/520,850
Other languages
English (en)
Inventor
Burkhard Mathies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Medidom SA
Original Assignee
Laboratoire Medidom SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Medidom SA filed Critical Laboratoire Medidom SA
Priority to US12/520,850 priority Critical patent/US20100136082A1/en
Assigned to LABORATOIRE MEDIDOM S.A. reassignment LABORATOIRE MEDIDOM S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MATHIES, BURKHARD
Publication of US20100136082A1 publication Critical patent/US20100136082A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30766—Scaffolds for cartilage ingrowth and regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30971—Laminates, i.e. layered products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof

Definitions

  • the present invention is in the field of bioaffecting and body treating compositions having components associated as layers or impregnated matrix (believed to be classified in Class 424/400). Specifically, the present invention relates to compositions in a physical form to adapt for surgical implanting or inserting in the living body (believed to be classified in Class 424/400; 423). More specifically, the present invention relates to such compositions in which the surgical implant or material is errodable, resorbable, or dissolving (believed to be classified in Class 424/400; 423; 426).
  • the hyalinic articular cartilage is a specialized connective tissue in the body with weight bearing and shock absorbing properties and functions. Injury to or loss of this specialized connective tissue in a joint leads to pain and impaired joint function.
  • the orthopedic surgical arts field has been motivated to develop therapies which replace or promote regeneration of damaged joint cartilage. This is in response to the large number of joint injuries that occur yearly, and the increasing number of the elderly with joint problems.
  • these therapies are merely surgical methods which debride and mechanically repair the injury, with or without the addition to the injury site of an active composition to promote healing or to prevent inflammation/infection.
  • osteochondral injuries which are a combination lesion of bone and cartilage, represent therapeutic challenges, and fully satisfactory therapeutic compositions and treatment methods are still lacking in many cases.
  • certain surgical procedures for osteochondritis dissecans using autologous chondrocyte transplantation require extensive periods for the cell cultivation and growth aspect and multiple surgeries.
  • these therapies often result in the propagation of a fibrocartilaginous replacement tissue, which is a poor substitute for hyaline articular cartilage. See J. Kramer et al., Cell. Mol. Life Sci., 63, 616-626 (2006).
  • the present invention is an in situ healing/tissue growth promoting system and method, utilizing natural, non-human Hyaluronic Acid and 5 autologous mesenchymal stem cells to regenerate intra-articular cartilage lesions. More specifically, a system and method is provided that can stimulate growth of hyaline-like cartilage in situ to correct intra-articular cartilage defects.
  • the present system comprises a medical cartilage repair patch consisting of a natural composite 10 Hyaluronic Acid and collagen fiber matrix additionally embedded with growth hormones and/or growth factors, and Diacerein and/or Rhein compositions.
  • the system utilizes autologous mesenchymal stem-cells obtained through micro-fracture of the subchondral bone during installation of the cartilage repair patch as a component of the system to accomplish chondral and osseous tissue engineering in intra-articular defects.
  • the implantable laminate cartilage repair patch of the present invention is a surgical device that is bio-compatible and physiologically absorbable for in situ cartilage repair in intra-articular lesions.
  • the cartilage repair patch is a laminate or multi-layered device.
  • the device has a basement or bottom layer which is adapted to be disposed adjacent the bone site to be treated. This layer is “cell-porous” in that it allows the migration of cells from the wound site to pass through the layer.
  • On top of and closely associated with the basement layer is a cartilagenic matrix layer.
  • the cartilagenic matrix is a collagenous layer and is a sink for the diffusion of autologous stem cells and other blood components at the wound site.
  • the matrix layer includes chemical components which promote the generation of hyaline-like cartilage in the presence of the autologous stem cells.
  • the top layer may be occlusive to one degree or another, for example, not allow cells to pass through, but allowing other small things, like water, gas and small molecules to pass through. All of these elements and features in combination provide the flexible, bio-compatible materials which are physiologically absorbable laminate cartilage repair patch of the present invention.
  • FIG. 1 is a cross-sectional view of subchondral bone showing a chondral/osteo-chondral lesion where a section of cartilage covering the osseous portion of the bone is missing.
  • FIG. 2A is a cross-sectional side view of the sterilizeable, flexible laminate wound cartilage repair patch of the present invention, detailing the composition of the matrix of the patch wherein the collagen and the Hyaluronic Acid are disposed as fibers.
  • FIG. 2B is a cross-sectional side view of the sterilizeable, flexible laminate wound cartilage repair patch of the present invention, detailing the composition of the inner matrix of the patch, wherein the collagen is disposed as fibers and the Hyaluronic Acid is disposed as a cream suspension or as a viscoelastic solution.
  • FIG. 2C is a cross-sectional side view of the sterilizeable, flexible laminate wound cartilage repair patch of the present invention, showing a lower and an upper layer both having a mechanical stabilizing feature in each layer.
  • FIG. 2D is a cross-sectional side view of the sterilizeable, flexible laminate wound cartilage repair patch of the present invention, showing an embodiment having only a lower layer and with a mechanical stabilizing feature.
  • FIG. 2E is a cross-sectional side view of the sterilizeable, flexible laminate wound cartilage repair patch of the present invention, showing an embodiment wherein the lower layer has complex mechanical stabilizing features in it.
  • FIG. 3 is a generalized flow chart illustrating the main stages of the method of the present inventive system.
  • FIGS. 4A and 4B are cross-sectional views of a representative wound site and illustrate a first stage of preparation of the wound site to receive the present flexible laminate cartilage repair patch: (A) causing micro-fractures or perforations into the surface of the subchondral bone, and (B) forming a blood clot from local bleeding initiated by the causing of the micro-fractures.
  • FIG. 5 is a cross-sectional view of a representative wound site and illustrates a step of the second stage of the present system: applying the autologous serum enhanced “fibrin glue” at the wound site.
  • FIG. 6A is a cross-sectional view of a representative wound site and illustrates the placement of the flexible laminate cartilage repair patch to the wound site over a fibrin glue/blood clot.
  • FIG. 6B is a cross-sectional view of a representative wound site and illustrates the migration of Mesenchymal Stem Cells and other injury responsive blood components from the blood clot into the fibrin glue to form a blood clot/fibrin glue composite.
  • FIG. 6C is a cross-sectional view of a representative wound site and illustrates the migration of Mesenchymal Stem Cells and other injury responsive blood components from the blood clot/fibrin glue composite further still into the matrix of the cartilage repair patch.
  • FIG. 7 is a cross-sectional view of a representative wound site and illustrates the resultant repaired site after the cartilage repair patch has been reabsorbed and the site transformed into bone and/or a hyaline-like cartilage.
  • one of the problems faced in this field is how to promote regeneration of a cartilaginous tissue at the defect or wound site (cartilage lesion) 6 that is as close as possible to the natural cartilage 8 proximate the site, or as otherwise would have covered the subchondral bone 4 at the site 6 .
  • This is particularly challenging at wound sites where the lesion involve both cartilage and bone.
  • the present invention is an implantable cartilage repair patch 10 that is bio-compatible and physiologically absorbable, and that functions in situ to promote the regeneration of cartilage in intra-articular chondral or osteo-chondral lesions 6 (see FIG. 1 ).
  • the present cartilage repair patch 10 is a sterilizeable, flexible laminate 12 that can be implanted at a wound site 6 and act to promote the generation of hyaline-like cartilage.
  • the objective of the cartilage repair patch 10 is to stimulate growth of hyaline-like cartilage in-situ following arthroscopic or open surgical application of the cartilage repair patch 10 in patients with chondral or osteo-chondral damage.
  • An additional object is that the cartilage repair patch 10 is biodegradable through the interaction of its constituents with collagenase and other proteases and will be reabsorbed and disappear over time.
  • the laminate 12 of the cartilage repair patch 10 is constructed completely of materials that are both bio-compatible and physiologically absorbable, so that the cartilage repair patch can be implanted indwelling in a patient and disappear from the implantation site over time.
  • the cartilage repair patch laminate 12 has a first top (optionally occlusive) layer 16 , and a second bottom or basement porous layer 22 . See FIGS. 2A to 2C .
  • the cartilage repair patch laminate 12 is only two layers: a basement layer 22 and a matrix layer 30 . See FIGS. 2D and 2E .
  • the basement layer is intended to be interfaced with the surface of the bone at the wound site 6 .
  • Both of the basement layer 16 and the top layer 22 are made of sheet collagen (see Angele et al., U.S. Pat. No. 6,737,072. The content of which is incorporated herein by reference).
  • An example of a satisfactory commercially available source of sheet collagen is: XENODERMTM, Biometica AG, Switzerland.
  • Disposed on the porous basement layer 22 is a cartilagenic matrix layer 30 .
  • the cartilagenic matrix layer 30 provides a collagenous substrate in which to entrap mesenchymal stem-cells, and a cell growth support medium on which they will grow and differentiate into chondrocytes in presence of the other natural components of the matrix layer 30 .
  • the matrix layer 30 is a sterile or sterilizeable, porous collagenous composite pad, interspersed with non-human collagen fibers 36 and natural Hyaluronic Acid fibers 40 .
  • the natural collagen is derived from a non-human source, such as porcine, bovine or vegetal collagen.
  • the natural Hyaluronic Acid (HA) is derived from a natural non-mammalian source, such as via bacterial fermentation and via extraction from rooster combs. Other names for HA include: hyaluronic acid sodium salt, sodium hyaluronate, and hyaluronan.
  • the natural HA can be provided in the matrix 30 in form of natural HA fibers 40 as shown in FIG. 2A , or as HA powder 40 a in a gel or cream suspension 42 dispersed into the vacant spaces of the collagen fibers 36 as in FIG. 2B .
  • the composite cartilagenic matrix 30 also includes one or more tissue growth hormones (e.g., Somatotropine) and/or stimulators of growth factors 46 .
  • Growth factor stimulators are chemicals that enhance the expression of a growth factor at a given site.
  • the growth factor stimulators are Diacerein 46 a and Rhein 46 b.
  • the suspension 42 also contains Rhein 46 b and/or Diacerein 46 a.
  • the weight range ratio of collagen to HA should be from about 0.1:99.9 to about 50:50 when the natural HA has a molecular weight of between 0.5 to 6 million Dalton.
  • Diacerein or Rhein concentrations should be in the range of about 10 to 50 micromolar added to the matrix in a powder form or as HA gel or cream containing the Diacerein or Rhein.
  • Other compositions that are anticipated for inclusion in the matrix layer 30 include Chitosan compositions and Poly-Lactic Acid compositions.
  • the matrix fibers 40 & 40 a provide a support medium for the stem cells to grow and differentiate into chondrocytes.
  • the exogenous growth factors 46 such as Diacerein down regulate inflammatory parameters (e.g., cytokines: IL-1, TNF-alpha, alpha, and free radicals) which contribute to inflammation and cartilage breakdown.
  • Diacerein stimulates the production of certain growth factors, like TGF- ⁇ that additionally will stimulate production of cartilage components such as HA, collagen type-II, and proteoglycans (including aggrecans). Growth hormone will stimulate the production of cartilage and bone tissue. Further, endogenous growth factors 50 from an autologous serum fraction are added to the fibrin glue composition 54 stimulates differentiation of stem cells 60 in the blood clot/patch interface. The cumulative effect of these interactions leads to growth of hyaline-like cartilage.
  • FIG. 3 is a generalized flow chart illustrating the main stages of the method of the present inventive system.
  • the present system comprises three stages: preparation of the wound site 100 ; preparation and installation of the fibrin glue 120 ; and application of the cartilage repair patch 140 .
  • a blood sample is taken from the patient and an autologous serum fraction is obtained.
  • the autologous serum fraction is used as a source of wound healing components, such as TGF- ⁇ 1, and will be added at implantation within the fibrin-glue to the wound site 6 . These endogenous components will enhance mesenchymal stem cell differentiation.
  • micro-fractures/perforations are made at the subchondral bone surface 14 to cause local bleeding 58 which perfuses the wound site 6 with fresh blood. See FIG. 4A .
  • Causing local bleeding 58 at the subchondral bone surface 14 can be accomplished in a number of ways.
  • the preparation of the existing chondral or osteochondral lesions is accomplished by causing micro-fractures or perforations 56 in the surface 14 of the subchondral bone 4 —often associated with abrasion of sclerotic bone.
  • the micro-fractures/perforations/abrasions 56 in the subchondral bone 4 causes bleeding 58 into the wound site 6 .
  • the blood 58 entering the wound site 6 contains autologous mesenchymal stem cells 60 and other healing components released by the subchondral bone 4 in response to the causing of the micro-fractures, perforations or abrasions 56 .
  • the blood 58 that perfuses the wound site 6 results in a blood clot 59 that forms at the site.
  • the present system uses the micro-fracture technique to cause bleeding and stimulate release of autologous mesenchymal stem cells (MSCs) and growth factors into the clot 59 .
  • MSCs autologous mesenchymal stem cells
  • These pluripotential MSCs in the presence of the present cartilage repair patch 10 will differentiate into chondrocytes and produce extracellular hyaline-like cartilage matrix to repair/replace the existing chondral/osteo-chondral lesion 6 .
  • the second stage 120 of the method of the present system is accomplished.
  • This stage 120 is the preparation and application of the fibrin glue 54 to the blood clot 59 at the wound site 6 .
  • the fibrin glue 54 mingles with the fresh blood clot to form a blood clot/fibrin glue composite clot 54 - 59 .
  • other means of installing the fibrin glue 54 in place are known to and selectable by one of ordinary skill in the art for practice in the present system.
  • the cartilage repair patch 10 can be sutured in place (not shown).
  • the third stage 140 of the present method is then to be accomplished.
  • This third stage 140 is the placement of the flexible laminate repair patch 10 to the wound site over the fibrin glue/blood clot composite 59 / 54 at the wound site 6 .
  • the flexible laminate cartilage repair patch 10 is applied to the wound site 6 .
  • the fibrin glue 54 also may be freely applied after the repair patch 10 is in place to further accomplish adhering the repair patch 10 to the wound site 6 .
  • the surgical stages of the present system are completed and the cartilage repair patch 10 continues healing purpose in situ.
  • FIG. 6B Mesenchymal Stem Cells and other injury responsive blood components from the blood clot 59 migrate into the fibrin glue 54 .
  • FIG. 6C illustrates the further migration of the Mesenchymal Stem Cells and other injury responsive blood components from the fibrin glue/blood clot composite 54 / 59 continues through the porous outer layer 22 and into the matrix layer 30 of the cartilage repair patch 10 .
  • the mesenchymal stem cells and autologous growth factors interact with the constituents of the cartilage repair patch 10 .
  • the presence of these components results from their diffusion from the clot 59 into the cartilagenic matrix 30 of the cartilage repair patch 10 .
  • the occlusive layer 16 of the cartilage repair patch 10 prevents for a time the further diffusion of these different compositions into the joint space. Conversely, the mobile constituents of the matrix layer 30 can migrate out of the cartilage repair patch and into the mass of the fibrin clot 54 , and further, into the blood clot 59 at the surface 14 of the subchrondral bone 4 .
  • the Diacerein 46 a and the Rhein 46 b inhibit the production and activity of inflammatory cytokines such as IL-1 ⁇ , nitric oxide (NO), free radicals and matrix metalloproteinases all of which are involved in inflammation and cartilage destruction, particular in osteoarthritic joints.
  • the Diacerein 46 a and the Rhein 46 b also stimulate the production of growth factors such as TGF- ⁇ which in turn stimulates expression of cartilage components such as hyaluronic acid, proteoglycans, aggrecans and collagenase II, all of which are important components of cartilage matrix.
  • the growth hormone will also stimulate the growth of cartilage and bone tissue. Over time, as illustrated in FIG. 7 , the cartilage repair patch 10 is reabsorbed and the defect site 6 is relatively rapidly transformed into a more physiologically hyaline-like cartilage 90 .
  • a collagen sheet 22 (Xenoderm—porcine type 1 and 2 collagen) was used for the lower layer 22 .
  • the Lower layer had mechanical properties to resist shear and pull stress and was resorbable in about 6 weeks.
  • the collagen sheet 22 was put into a form, and then loaded with a collagen-HA suspension to which was added either a solution of Diacerein or Diacerein powder to obtain a concentration of 5-50 micromol. in dry-weight in patch after freeze-drying and sterilization.
  • the result is a double layer collagen-pad with the lower layer to be disposed adjacent the bone surface. After manufacturing and before sterilization, the pads are put into a mechanical press to obtain a thickness of 0.5-2 mm.
  • HA-concentration in the dry-frozen end product was in the range of about 0.1% to 2%.
  • the HA is natural HA, that is, non-chemically modified HA, of fermentation origin.
  • a device and therapy is provided which better promotes regeneration of damaged joint cartilage.
  • a treatment and device for osteochondral injuries is provided that does not require cell culture.
  • a treatment and device for such injuries that does not result in propagation of a fibrocartilaginous replacement tissue at the injury site.
  • a treatment and device which better insures that the resultant replacement tissue is appreciably representative of natural hyaline-like articular cartilage.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
US12/520,850 2006-12-22 2007-12-21 In situ system for intra-articular chondral and osseous tissue repair Abandoned US20100136082A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/520,850 US20100136082A1 (en) 2006-12-22 2007-12-21 In situ system for intra-articular chondral and osseous tissue repair

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87155406P 2006-12-22 2006-12-22
US12/520,850 US20100136082A1 (en) 2006-12-22 2007-12-21 In situ system for intra-articular chondral and osseous tissue repair
PCT/IB2007/004067 WO2008078166A2 (fr) 2006-12-22 2007-12-21 Système in situ pour une réparation du tissu chondral et osseux intra-articulaire

Publications (1)

Publication Number Publication Date
US20100136082A1 true US20100136082A1 (en) 2010-06-03

Family

ID=39294074

Family Applications (2)

Application Number Title Priority Date Filing Date
US12/520,850 Abandoned US20100136082A1 (en) 2006-12-22 2007-12-21 In situ system for intra-articular chondral and osseous tissue repair
US11/962,228 Expired - Fee Related US9592125B2 (en) 2006-12-22 2007-12-21 In situ system for intra-articular chondral and osseous tissue repair

Family Applications After (1)

Application Number Title Priority Date Filing Date
US11/962,228 Expired - Fee Related US9592125B2 (en) 2006-12-22 2007-12-21 In situ system for intra-articular chondral and osseous tissue repair

Country Status (11)

Country Link
US (2) US20100136082A1 (fr)
EP (1) EP2097116B1 (fr)
JP (1) JP5295121B2 (fr)
KR (1) KR101424308B1 (fr)
BR (1) BRPI0722363B8 (fr)
CA (1) CA2674524C (fr)
DK (1) DK2097116T3 (fr)
ES (1) ES2395149T3 (fr)
PT (1) PT2097116E (fr)
RU (1) RU2451527C2 (fr)
WO (1) WO2008078166A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3150184A1 (fr) 2015-09-29 2017-04-05 Fundacja Rozwoju Kardiochirurgii Im. Prof. Zbigniewa Religi Dispositif médical

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2403357T3 (es) 2003-12-11 2013-05-17 Isto Technologies Inc. Sistema de cartílago particulado
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
JP5292533B2 (ja) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
WO2008128075A1 (fr) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions et procédés de réparation de tissu
WO2009133430A1 (fr) * 2008-04-30 2009-11-05 Wockhardt Research Centre Compositions topiques de rhéine ou de diacéréine
US8114156B2 (en) * 2008-05-30 2012-02-14 Edwin Burton Hatch Flexibly compliant ceramic prosthetic meniscus for the replacement of damaged cartilage in orthopedic surgical repair or reconstruction of hip, knee, ankle, shoulder, elbow, wrist and other anatomical joints
KR101114773B1 (ko) * 2009-10-23 2012-03-05 세원셀론텍(주) 연골조직 수복용 조성물의 제조방법
RU2461621C1 (ru) * 2011-08-25 2012-09-20 Учреждение Российской академии наук Государственный Научный Центр РФ Институт медико-биологических проблем РАН Способ стимуляции формирования фиброзно-хрящевого регенерата костной мозоли у млекопитающих
RS58902B1 (sr) * 2012-03-22 2019-08-30 Trb Chemedica Int S A Postupak za obnavljanje ligamenta ili tetive
KR101279812B1 (ko) * 2012-05-16 2013-06-28 세원셀론텍(주) 연골조직 수복용 조성물의 제조방법
EP2903567B1 (fr) 2012-10-02 2017-08-09 McCullen, Seth Dispositifs implantables pour une réparation ou une régénération musculosquelettique
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
KR101401944B1 (ko) * 2012-12-11 2014-05-30 세원셀론텍(주) 콜라겐과 피브린이 혼합된 조직 실란트 및 그 제조방법
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014151939A1 (fr) * 2013-03-15 2014-09-25 Allosource Compositions d'allogreffe ostéochondrale perforée
EP3151848A4 (fr) * 2014-06-06 2018-01-24 Vivoscript, Inc. Méthode de réparation de lésion cartilagineuse
EP3613386A1 (fr) 2014-10-02 2020-02-26 McCullen, Seth Dispositifs implantables dans le ménisque conçus anatomiquement
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
RU2620884C1 (ru) * 2016-08-10 2017-05-30 Анна Петровна Ведяева Способ направленной регенерации костной ткани
WO2018204440A2 (fr) 2017-05-02 2018-11-08 Mccullen Seth Implant articulaire composite

Citations (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350629A (en) * 1981-07-29 1982-09-21 Massachusetts Institute Of Technology Procedures for preparing composite materials from collagen and glycosaminoglycan
US4703108A (en) * 1984-03-27 1987-10-27 University Of Medicine & Dentistry Of New Jersey Biodegradable matrix and methods for producing same
US4837024A (en) * 1984-02-24 1989-06-06 The Regents Of The University Of California Compositions, articles and mehtod for improving wound healing
US4880429A (en) * 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US5067964A (en) * 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
US5397353A (en) * 1984-05-24 1995-03-14 Oliver; Roy F. Implant tissue
US5567806A (en) * 1991-08-02 1996-10-22 Abdul-Malak; Nabil Collagen crosslinked with a crosslinking agent for the manufacture of a suturable, biocompatible slowresorbing membrane, and such a membrane
US5681353A (en) * 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US20020025921A1 (en) * 1999-07-26 2002-02-28 Petito George D. Composition and method for growing, protecting, and healing tissues and cells
US6352558B1 (en) * 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
US20020028233A1 (en) * 2000-08-18 2002-03-07 Dimitrijevich Slobodan Dan Pericardial anti-adhesion patch
US20020045940A1 (en) * 1998-08-14 2002-04-18 Bruno Giannetti Methods, instruments and materials for chondrocyte cell transplantation
US20020103542A1 (en) * 2000-09-18 2002-08-01 Bilbo Patrick R. Methods for treating a patient using a bioengineered flat sheet graft prostheses
US20020111576A1 (en) * 2000-12-29 2002-08-15 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
US20020122790A1 (en) * 2001-01-30 2002-09-05 Hunziker Ernst B. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US20020151985A1 (en) * 1990-05-29 2002-10-17 Stryker Corporation Synthetic bone matrix
US20020151986A1 (en) * 1996-08-30 2002-10-17 Asculai Samuel S. Method, Instruments,and kit for autologous tansplantation
US20020173806A1 (en) * 1996-08-30 2002-11-21 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US20020183845A1 (en) * 2000-11-30 2002-12-05 Mansmann Kevin A. Multi-perforated non-planar device for anchoring cartilage implants and high-gradient interfaces
US20020183858A1 (en) * 2001-06-05 2002-12-05 Contiliano Joseph H. Attachment of absorbable tissue scaffolds to scaffold fixation devices
US20030004578A1 (en) * 2001-06-28 2003-01-02 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US20030036801A1 (en) * 2001-07-16 2003-02-20 Schwartz Herbert E. Cartilage repair apparatus and method
US20030078617A1 (en) * 2001-07-16 2003-04-24 Schwartz Herbert E. Unitary surgical device and method
US20030114061A1 (en) * 2001-12-13 2003-06-19 Kazuhisa Matsuda Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same
US20030118560A1 (en) * 2001-12-20 2003-06-26 Kelly Sheila J. Composite biocompatible matrices
US6596304B1 (en) * 1998-09-18 2003-07-22 Imedex Biomateriaux Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions
US20030143207A1 (en) * 2001-10-18 2003-07-31 Livesey Stephen A. Remodeling of tissues and organ
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US6629997B2 (en) * 2000-03-27 2003-10-07 Kevin A. Mansmann Meniscus-type implant with hydrogel surface reinforced by three-dimensional mesh
US20030219429A1 (en) * 1998-07-24 2003-11-27 Pharmacal Biotechnologies, Llc Composition and method for bone regeneration
US20030220700A1 (en) * 2002-05-22 2003-11-27 Hammer Joseph J. Attachment of absorbable tissue scaffolds ot fixation devices
US20030225355A1 (en) * 1998-10-01 2003-12-04 Butler Charles E. Composite material for wound repair
US6737072B1 (en) * 1998-12-03 2004-05-18 Michael Nerlich Matrix for tissue engineering formed of a hyaluronic acid ester and hydrolyzed collagen
US20040097612A1 (en) * 2002-11-15 2004-05-20 Etex Corporation Cohesive demineralized bone compositions
US20040141945A1 (en) * 2001-04-02 2004-07-22 Hirofumi Yura Glycosaminoglycan/collagen complexes and use thereof
US20040224022A1 (en) * 2000-08-30 2004-11-11 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
US20050043814A1 (en) * 2003-08-20 2005-02-24 Akihiko Kusanagi Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US20050125077A1 (en) * 2003-12-05 2005-06-09 Harmon Alexander M. Viable tissue repair implants and methods of use
US20050186283A1 (en) * 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US20050208114A1 (en) * 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
US20050209705A1 (en) * 2004-03-09 2005-09-22 Niederauer Gabriele G Implant scaffold combined with autologous or allogenic tissue
US20050232979A1 (en) * 2002-06-03 2005-10-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-layer collagenic article useful for wounds healing
US20050232967A1 (en) * 2004-04-20 2005-10-20 Kladakis Stephanie M Nonwoven tissue scaffold
US20050281856A1 (en) * 2004-05-10 2005-12-22 Mcglohorn Jonathan Implantable biostructure comprising an osteoconductive member and an osteoinductive material
US20060008905A1 (en) * 2001-10-19 2006-01-12 Ralph-Heiko Mattern Collagen/glycosaminoglycan compositions for use as terminally sterilizable matrices
US6989034B2 (en) * 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US20060083730A1 (en) * 2003-08-20 2006-04-20 Akihiko Kusanagi Method for treatment of osteochondral and bone defects using an acellular matrix implant
US20060100138A1 (en) * 2004-11-10 2006-05-11 Olsen David R Implantable collagen compositions
US20060241756A1 (en) * 2003-10-13 2006-10-26 Aesculap Ag & Co., Kg Cartilage replacement implant and method for producing a cartilage replacement implant
US7141072B2 (en) * 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
US20080119947A1 (en) * 2006-11-18 2008-05-22 Smith & Nephew, Inc. Annular Ring Implant
US20080125863A1 (en) * 2006-11-28 2008-05-29 Mckay William F Implant designs and methods of improving cartilage repair
US20080183300A1 (en) * 1999-12-03 2008-07-31 University Of Leeds Fixation technology
US7476250B1 (en) * 1999-04-06 2009-01-13 Mansmann Kevin A Semi-permeable membranes to assist in cartilage repair

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249315B (it) 1991-05-23 1995-02-22 Euroresearch Srl Lamina di collageno non poroso per uso terapeutico, metodo ed apparecchiature per ottenerlo
EP0544259A1 (fr) 1991-11-27 1993-06-02 Lignyte Co., Ltd. Complexe hyaluronique et polyionique biocompatible insoluble dans l'eau et son procédé de préparation
CA2130295A1 (fr) 1993-08-26 1995-02-27 Richard A. Berg Gels a glycosaminoglycanes reticulees a liaisons ioniques utilises pour l'augmentation des tissus mous et la liberation des principes actifs
GB9400163D0 (en) 1994-01-06 1994-03-02 Geistlich Soehne Ag Membrane
EP0871414B1 (fr) 1994-03-14 2004-04-28 Cryolife, Inc Procedes pour la preparation de tissu pour l'implantation
GB9503492D0 (en) 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
GB9721585D0 (en) * 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
US20030039695A1 (en) 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
JP3476631B2 (ja) 1995-12-21 2003-12-10 株式会社アムニオテック ヒト由来の天然コラーゲン膜からなる医用材料
US5824084A (en) 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
EP1021204B1 (fr) * 1997-09-26 2005-12-28 Noven Pharmaceuticals, Inc. Compositions bioadhesives et methodes d'administration locale d'agents actifs
US20030180263A1 (en) 2002-02-21 2003-09-25 Peter Geistlich Resorbable extracellular matrix for reconstruction of bone
US6004333A (en) 1997-10-31 1999-12-21 Ethicon Endo-Surgery, Inc. Prosthetic with collagen for tissue repair
WO2000016822A1 (fr) 1998-09-21 2000-03-30 The Brigham And Women's Hospital, Inc. Reparations tissulaires et compositions a cet effet
EP1022031B1 (fr) 1999-01-21 2005-03-23 Nipro Corporation Membrane suturable pour la prévention d'adhérences
CA2362600A1 (fr) 1999-02-16 2000-08-24 Sulzer Biologics Inc. Dispositif et procede de regeneration et de reparation des lesions du cartilage
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
JP2003525703A (ja) 2000-03-09 2003-09-02 シンタコール アーゲー 人および獣の医薬に使用するための改良された性質を備えた新規な天然ポリマーを基材とする材料およびその製造方法
GB0006439D0 (en) 2000-03-18 2000-05-10 Univ Nottingham Polymeric composite materials and their manufacture
JP4273450B2 (ja) 2000-12-07 2009-06-03 有限会社テクノサージ 組織再生用基材、移植用材料及びそれらの製法
AU784394B2 (en) 2001-04-27 2006-03-23 Geistlich Pharma Ag Method and membrane for mucosa regeneration
JP2003160506A (ja) 2001-08-10 2003-06-03 Ed Geistlich Soehne Ag Fuer Chemische Industrie 治療用遺伝物質のコラーゲン担体およびその方法
US8049059B2 (en) 2001-10-26 2011-11-01 Cook Biotech Incorporated Medical graft device with meshed structure
CA2412012C (fr) * 2001-11-20 2011-08-02 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Matrice extracellulaire resorbable contenant du collagene i et du collagene ii pour la reconstruction de cartilage
DE60323943D1 (de) 2002-02-21 2008-11-20 Encelle Inc Immobilisierte bioaktive hydrogel matrizen für oberflächenbeschichtungen
JP2003245338A (ja) * 2002-02-26 2003-09-02 Kyocera Corp 関節軟骨修復材
US20040034418A1 (en) * 2002-07-23 2004-02-19 Shu-Tung Li Membrane-reinforced implants
EP1605862A4 (fr) 2003-02-28 2008-09-03 Fibrogen Inc Compositions et biomateriaux de collagene
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
ITMI20040347A1 (it) * 2004-02-26 2004-05-26 Pharma Medical Ltd Nuovo farmaco di associazione
US20070237799A1 (en) 2004-04-15 2007-10-11 Dieter Scharnweber Osteogenic Composite Matrix, Method for the Production Thereof and Implant and Scaffold for Tissue Engineering Provided with a Coating Formed by Said Osteogenic Composite matrix
GB0516846D0 (en) 2005-08-17 2005-09-21 Knight David P Meniscal repair device
WO2007032404A1 (fr) 2005-09-16 2007-03-22 St. Marianna University, School Of Medicine Biomatériau pour la médecine régénérative
WO2007049125A1 (fr) 2005-10-24 2007-05-03 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Procede et dispositif pour gel ou membrane de collagene charges de cellules synoviales
EP1968499A1 (fr) 2005-12-14 2008-09-17 Anika Therapeutics Inc. Implant bioabsorbable de derive d'acide hyaluronique destine au traitement de defauts chondraux et osteochondraux
CN1986007B (zh) 2005-12-20 2011-09-14 广东冠昊生物科技股份有限公司 生物型外科补片
CN105327393A (zh) 2006-06-22 2016-02-17 南佛罗里达大学 胶原支架、具有其的医用植入物以及使用方法
GB2440721A (en) 2006-08-11 2008-02-13 Univ Cambridge Tech Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrier
CA2667214C (fr) 2006-10-23 2015-12-01 Cook Biotech Incorporated Materiaux de matrice extracellulaire traites presentant des profils de composants ameliores
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
WO2009076391A2 (fr) 2007-12-10 2009-06-18 Cook Biotech Incorporated Matériaux médicaux comprenant des matériaux de matrice extracellulaire modifiés

Patent Citations (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350629A (en) * 1981-07-29 1982-09-21 Massachusetts Institute Of Technology Procedures for preparing composite materials from collagen and glycosaminoglycan
US4837024A (en) * 1984-02-24 1989-06-06 The Regents Of The University Of California Compositions, articles and mehtod for improving wound healing
US4703108A (en) * 1984-03-27 1987-10-27 University Of Medicine & Dentistry Of New Jersey Biodegradable matrix and methods for producing same
US5397353A (en) * 1984-05-24 1995-03-14 Oliver; Roy F. Implant tissue
US4880429A (en) * 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US5681353A (en) * 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US6042610A (en) * 1987-07-20 2000-03-28 Regen Biologics, Inc. Meniscal augmentation device
US5067964A (en) * 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
US20020151985A1 (en) * 1990-05-29 2002-10-17 Stryker Corporation Synthetic bone matrix
US5567806A (en) * 1991-08-02 1996-10-22 Abdul-Malak; Nabil Collagen crosslinked with a crosslinking agent for the manufacture of a suturable, biocompatible slowresorbing membrane, and such a membrane
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US6352558B1 (en) * 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
US20020151986A1 (en) * 1996-08-30 2002-10-17 Asculai Samuel S. Method, Instruments,and kit for autologous tansplantation
US20020173806A1 (en) * 1996-08-30 2002-11-21 Verigen Transplantation Service International (Vtsi) Ag Method for autologous transplantation
US20050186283A1 (en) * 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US20050208114A1 (en) * 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
US20030219429A1 (en) * 1998-07-24 2003-11-27 Pharmacal Biotechnologies, Llc Composition and method for bone regeneration
US20020045940A1 (en) * 1998-08-14 2002-04-18 Bruno Giannetti Methods, instruments and materials for chondrocyte cell transplantation
US6596304B1 (en) * 1998-09-18 2003-07-22 Imedex Biomateriaux Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions
US20030225355A1 (en) * 1998-10-01 2003-12-04 Butler Charles E. Composite material for wound repair
US7141072B2 (en) * 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
US6737072B1 (en) * 1998-12-03 2004-05-18 Michael Nerlich Matrix for tissue engineering formed of a hyaluronic acid ester and hydrolyzed collagen
US7476250B1 (en) * 1999-04-06 2009-01-13 Mansmann Kevin A Semi-permeable membranes to assist in cartilage repair
US20020025921A1 (en) * 1999-07-26 2002-02-28 Petito George D. Composition and method for growing, protecting, and healing tissues and cells
US20080183300A1 (en) * 1999-12-03 2008-07-31 University Of Leeds Fixation technology
US6629997B2 (en) * 2000-03-27 2003-10-07 Kevin A. Mansmann Meniscus-type implant with hydrogel surface reinforced by three-dimensional mesh
US20020028233A1 (en) * 2000-08-18 2002-03-07 Dimitrijevich Slobodan Dan Pericardial anti-adhesion patch
US20040224022A1 (en) * 2000-08-30 2004-11-11 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
US20020103542A1 (en) * 2000-09-18 2002-08-01 Bilbo Patrick R. Methods for treating a patient using a bioengineered flat sheet graft prostheses
US20020183845A1 (en) * 2000-11-30 2002-12-05 Mansmann Kevin A. Multi-perforated non-planar device for anchoring cartilage implants and high-gradient interfaces
US20020111576A1 (en) * 2000-12-29 2002-08-15 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
US20020122790A1 (en) * 2001-01-30 2002-09-05 Hunziker Ernst B. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US20040141945A1 (en) * 2001-04-02 2004-07-22 Hirofumi Yura Glycosaminoglycan/collagen complexes and use thereof
US20020183858A1 (en) * 2001-06-05 2002-12-05 Contiliano Joseph H. Attachment of absorbable tissue scaffolds to scaffold fixation devices
US20030004578A1 (en) * 2001-06-28 2003-01-02 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US20080167716A1 (en) * 2001-07-16 2008-07-10 Schwartz Hebert E Cartilage repair apparatus and method
US20030078617A1 (en) * 2001-07-16 2003-04-24 Schwartz Herbert E. Unitary surgical device and method
US20030036801A1 (en) * 2001-07-16 2003-02-20 Schwartz Herbert E. Cartilage repair apparatus and method
US20030143207A1 (en) * 2001-10-18 2003-07-31 Livesey Stephen A. Remodeling of tissues and organ
US20060008905A1 (en) * 2001-10-19 2006-01-12 Ralph-Heiko Mattern Collagen/glycosaminoglycan compositions for use as terminally sterilizable matrices
US20030114061A1 (en) * 2001-12-13 2003-06-19 Kazuhisa Matsuda Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same
US20030118560A1 (en) * 2001-12-20 2003-06-26 Kelly Sheila J. Composite biocompatible matrices
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US20030220700A1 (en) * 2002-05-22 2003-11-27 Hammer Joseph J. Attachment of absorbable tissue scaffolds ot fixation devices
US6989034B2 (en) * 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US20050232979A1 (en) * 2002-06-03 2005-10-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-layer collagenic article useful for wounds healing
US20040097612A1 (en) * 2002-11-15 2004-05-20 Etex Corporation Cohesive demineralized bone compositions
US20060083730A1 (en) * 2003-08-20 2006-04-20 Akihiko Kusanagi Method for treatment of osteochondral and bone defects using an acellular matrix implant
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
US20050043814A1 (en) * 2003-08-20 2005-02-24 Akihiko Kusanagi Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US20060241756A1 (en) * 2003-10-13 2006-10-26 Aesculap Ag & Co., Kg Cartilage replacement implant and method for producing a cartilage replacement implant
US20050125077A1 (en) * 2003-12-05 2005-06-09 Harmon Alexander M. Viable tissue repair implants and methods of use
US20050209705A1 (en) * 2004-03-09 2005-09-22 Niederauer Gabriele G Implant scaffold combined with autologous or allogenic tissue
US20050232967A1 (en) * 2004-04-20 2005-10-20 Kladakis Stephanie M Nonwoven tissue scaffold
US20050281856A1 (en) * 2004-05-10 2005-12-22 Mcglohorn Jonathan Implantable biostructure comprising an osteoconductive member and an osteoinductive material
US20060100138A1 (en) * 2004-11-10 2006-05-11 Olsen David R Implantable collagen compositions
US20080119947A1 (en) * 2006-11-18 2008-05-22 Smith & Nephew, Inc. Annular Ring Implant
US20080125863A1 (en) * 2006-11-28 2008-05-29 Mckay William F Implant designs and methods of improving cartilage repair

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3150184A1 (fr) 2015-09-29 2017-04-05 Fundacja Rozwoju Kardiochirurgii Im. Prof. Zbigniewa Religi Dispositif médical

Also Published As

Publication number Publication date
CA2674524C (fr) 2014-05-20
BRPI0722363B1 (pt) 2018-06-19
BRPI0722363B8 (pt) 2021-06-22
RU2009127080A (ru) 2011-01-27
EP2097116A2 (fr) 2009-09-09
BRPI0722363A2 (pt) 2014-06-03
US9592125B2 (en) 2017-03-14
WO2008078166A2 (fr) 2008-07-03
US20080154370A1 (en) 2008-06-26
JP5295121B2 (ja) 2013-09-18
RU2451527C2 (ru) 2012-05-27
CA2674524A1 (fr) 2008-07-03
JP2010512903A (ja) 2010-04-30
WO2008078166A3 (fr) 2009-05-07
DK2097116T3 (da) 2013-01-02
KR20090101273A (ko) 2009-09-24
KR101424308B1 (ko) 2014-08-01
PT2097116E (pt) 2012-12-06
ES2395149T3 (es) 2013-02-08
EP2097116B1 (fr) 2012-09-12

Similar Documents

Publication Publication Date Title
US9592125B2 (en) In situ system for intra-articular chondral and osseous tissue repair
US20220331491A1 (en) Scaffolds with viable tissue
RU2629809C2 (ru) Способ восстановления связки или сухожилия
JP4628756B2 (ja) 組織修復インプラント、その製造方法および組織修復方法
EP1656081B1 (fr) Implants de matrice acellulaire permettant de traiter des defauts et des blessures du cartilage articulaire, des os ou de type osteochondral et procede d'utilisation correspondant
JP4197160B2 (ja) 軟骨修復および再生用の支持骨格材料および方法
AU2004266710A1 (en) Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
AU2019222977A1 (en) Biomaterial for articular cartilage maintenance and treatment of arthritis
JP2008178670A (ja) 軟組織修復にコラゲナーゼを使った組織癒合法
CN112672717A (zh) 用于关节软骨修复的带有胶粘剂的支架
CN100486543C (zh) 带人工软骨结构的复合人工关节体
MX2013004125A (es) Parche para reparacion del cartilago.
CN1785441A (zh) 一种复合结构的组织工程化软骨移植物及制备方法
Zadeh Freeze-Dried Chitosan Platelet-Rich Plasma Mixtures for Knee Meniscus Repair
Maxson The development of a mesenchymal stem cell based biphasic osteochondral tissue engineered construct
Ikada Why is the Clinical Application of Tissue Engineering So Slow?

Legal Events

Date Code Title Description
AS Assignment

Owner name: LABORATOIRE MEDIDOM S.A.,SWITZERLAND

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MATHIES, BURKHARD;REEL/FRAME:023835/0360

Effective date: 20100113

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION