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US20070015163A1 - Novel full-length cDNA - Google Patents

Novel full-length cDNA Download PDF

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Publication number
US20070015163A1
US20070015163A1 US11/166,372 US16637205A US2007015163A1 US 20070015163 A1 US20070015163 A1 US 20070015163A1 US 16637205 A US16637205 A US 16637205A US 2007015163 A1 US2007015163 A1 US 2007015163A1
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United States
Prior art keywords
polypeptide
polynucleotide
clones
nucleotide sequence
protein
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US11/166,372
Inventor
Takao Isogai
Tomoyasu Sugiyama
Tetsuji Otsuki
Ai Wakamatsu
Hiroyuki Sato
Shizuko Ishii
Jun-Ichi Yamamoto
Yuuko Isono
Yuri Hio
Kaoru Otsuka
Keiichi Nagai
Ryotaro Irie
Ichiro Tamechika
Naohiko Seki
Tsutomu Yoshikawa
Motoyuki Otsuka
Kenji Nagahari
Yasuhiko Masuho
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Research Association for Biotechnology
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Research Association for Biotechnology
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Priority to US11/166,372 priority Critical patent/US20070015163A1/en
Publication of US20070015163A1 publication Critical patent/US20070015163A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Definitions

  • the present invention relates to polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and new uses of these.
  • the aim of the determination of genomic sequence is to reveal the functions of all genes and their regulation and to understand living organisms as a network of interactions between genes, proteins, cells or individuals through deducing the information in a genome, which is a blueprint of the highly complicated living organisms.
  • To understand living organisms by utilizing the genomic information from various species is not only important as an academic subject, but also socially significant from the viewpoint of industrial application.
  • genomic sequences itself cannot identify the functions of all genes. For example, as for yeast, only the function of approximately half of the 6000 genes, which is predicted based on the genomic sequence, was able to be deduced. On the other hand, the human genome has been estimated to contain about 30,000 genes. Further, 100,000 or more types of mRNAs are said to exist when variants produced by alternative splicing are taken into consideration. Therefore, it is desirable to establish “a high throughput analysis system of the gene functions” which allows us to identify rapidly and efficiently the functions of vast amounts of the genes obtained by the genomic sequencing.
  • cDNA which is produced from mRNA that lacks introns, encodes a protein as a single continuous amino acid sequence and allows us to identify the primary structure of the protein easily.
  • ESTs Expression Sequence Tags
  • ESTs The information of ESTs is utilized for analyzing the structure of human genome, or for predicting the exon-regions of genomic sequences or their expression profile.
  • many human ESTs have been derived from proximal regions to the 3′-end of cDNA, and information around the 5′-end of mRNA is extremely little.
  • human cDNAs the number of the corresponding mRNAs whose encoding full-length protein sequences are deduced is approximately 13,000.
  • a novel human full-length cDNA is isolated, it can be used for developing medicines for diseases in which the gene is involved.
  • the protein encoded by the gene can be used as a drug by itself. Thus, it has great significance to obtain a full-length cDNA encoding a novel human protein.
  • human secretory proteins or membrane proteins would be useful by itself as a medicine like tissue plasminogen activator (TPA), or as a target of medicines like membrane receptors.
  • TPA tissue plasminogen activator
  • genes for signal transduction-related proteins (protein kinases, etc.), glycoprotein-related proteins, transcription-related proteins, etc. are genes whose relationships to human diseases have been elucidated.
  • genes for disease-related proteins form a gene group rich in genes whose relationships to human diseases have been elucidated.
  • An objective of the present invention is to provide polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and novel usages of these.
  • the inventors have developed a method for efficiently cloning, from a cDNA library having very high fullness-ratio, a human full-length cDNA that is predicted to be a full-length cDNA clone, where the cDNA library is synthesized by an improved method (WO 01/04286) of the oligo-capping method (K. Maruyama and S. Sugano, Gene, 138: 171-174 (1994); Y. Suzuki et al., Gene, 200: 149-156 (1997)). Then, the nucleotide sequences of cDNA clones whose fullness ratio is high, obtained by this method, were determined mainly from their 5′-ends, and, if required, from 3′-ends.
  • the gene expression profiles of cDNA clones whose full-length nucleotide sequence had been determined were studied by analyzing the large-scale cDNA database constructed based on the 5′-end nucleotide sequences of cDNAs obtained.
  • the profiles of gene expression in living cells were also determined by PCR. The present inventors revealed the usefulness of the genes of the present invention based on these analysis results.
  • gene functions were revealed by the analysis of expression profiles in silico based on the information of full-length nucleotide sequences.
  • the expression profiles used in the expression frequency analysis were studied based on the database containing sufficient amount of fragment sequence data.
  • the expression frequency analysis was carried out by referring, for these expression profiles, to the full-length nucleotide sequences of many cDNA clones obtained in the present invention.
  • a highly reliable analysis can be achieved by referring to the full-length nucleotide sequences of a wide variety of genes for the sufficiently large population for analysis (expression profiles).
  • the results of expression frequency analysis using the full-length sequences of the present invention more precisely reflect the gene expression frequency in tissues and cells from which a certain cDNA library was derived.
  • the information of full-length cDNA nucleotide sequence of the present invention made it possible to achieve the highly reliable expression frequency analysis.
  • the full-length cDNA clones of this invention were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the high fullness ratio by oligo-capping, and [2] assembling 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • the uses of primers designed based on the 5′- and 3′-end sequences of polynucleotides provided by the present invention enable readily obtaining full-length cDNAs without such a special technique.
  • the primer which is designed to be used for obtaining cDNAs capable of being expressed, is not limited to the 5′- and 3′-end sequences of polynucleotide.
  • the present invention relates to a polynucleotide selected from the group consisting of the following (a) to (g):
  • a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted, and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
  • polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
  • a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of (a).
  • the present invention also relates to a polypeptide encoded by the above-mentioned polynucleotide or a partial peptide thereof, an antibody binding to the polypeptide or the peptide, and a method for immunologically assaying the polypeptide or the peptide, which comprises the steps of contacting the polypeptide or the peptide with the antibody, and observing the binding between the two.
  • the present invention features a vector comprising the above-mentioned polynucleotide, a transformant carrying the polynucleotide or the vector, a transformant carrying the polynucleotide or the vector in an expressible manner, and a method for producing the polypeptide or the peptide, which comprises the steps of culturing the transformant and recovering an expression product.
  • Another feature of the present invention is an oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1639 or to a complementary strand thereof.
  • This oligonucleotide can be used as a primer for synthesizing the above-mentioned polynucleotide or used as a probe for detecting the polynucleotide.
  • the present invention includes an antisense polynucleotide against the polynucleotide or a part thereof, and a method for detecting the polynucleotide, which comprises the following steps of:
  • Still another feature of the present invention is a database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 1639 and/or on at least one of the amino acid sequences of SEQ ID NOs: 1640 to 3278.
  • polynucleotide is defined as a molecule, such as DNA and RNA, in which multiple nucleotides are polymerized. There are no limitations on the number of the polymerized nucleotides. In case that the polymer contains relatively low number of nucleotides, it is also described as an “oligonucleotide”, which is included in the “polynucleotide” of the present invention.
  • the polynucleotide or the oligonucleotide of the present invention can be a natural or chemically synthesized product. Alternatively, it can be synthesized using a template polynucleotide by an enzymatic reaction such as PCR.
  • the polynucleotide of the present invention may be modified chemically. Moreover, not only a single-strand polynucleotide but also a double-strand polynucleotide is included in the present invention.
  • polynucleotide when the polynucleotide is described merely as “polynucleotide”, it means not only a single-strand polynucleotide but also a double-strand polynucleotide.
  • the nucleotide sequence of only one chain is indicated. However, based on the nucleotide sequence of a sense chain, the nucleotide sequence of the complementary strand thereof is essentially determined.
  • an “isolated polynucleotide” is a polynucleotide the structure of which is not identical to that of any naturally occurring polynucleotide or to that of any fragment of a naturally occurring genomic polynucleotide spanning more than three separate genes.
  • the term therefore includes, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule in the genome of the organism in which it naturally occurs; (b) a polynucleotide incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion polypeptide.
  • substantially pure protein or polypeptide as used herein in reference to a given protein or polypeptide means that the protein or polypeptide is substantially free from other biological macromolecules.
  • the substantially pure protein or polypeptide is at least 75%, 80%, 85%, 95%, or 99% pure by dry weight. Purity can be measured by any appropriate standard method known in the art, for example, by column chromatography, polyacrylamide gel electrophoresis, or HPLC analysis.
  • All the cDNAs provided by the present invention are full-length cDNAs.
  • the “full-length cDNA” herein means that the cDNA contains the ATG codon, which is the start point of translation therein.
  • the untranslated regions upstream and downstream of the protein-coding region, both of which are naturally contained in natural mRNAs, are not indispensable. It is preferable that the full-length cDNAs of the present invention contain the stop codon.
  • FIG. 1 shows the restriction map of the vector pME18SFL3.
  • All the clones (1639 clones) of the present invention are novel and encode the full-length polypeptides. Further, all the clones are cDNAs with the high fullness ratio, which were obtained by oligo-capping method, and also clones which are not identical to any of known human mRNAs (namely, novel clones) selected by searching, for the 5′-end sequences, mRNA sequences with the annotation of “complete cds” in the GenBank and UniGene databases by using the BLAST homology search [S. F. Altschul, W. Gish, W. Miller, E. W. Myers & D. J. Lipman, J. Mol. Biol., 215: 403-410 (1990); W. Gish & D. J.
  • All the full-length cDNAs of the present invention can be synthesized by a method such as PCR (Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4) using primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence.
  • PCR Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4
  • primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence.
  • Table 1 contains the clone names of full-length cDNA of 1639 clones of the present invention, SEQ ID NOs of the full-length nucleotide sequences, CDS portions deduced from the full-length nucleotide sequences, and SEQ ID NOs of the translated amino acids.
  • the positions of CDS are shown according to the rule of “DDBJ/EMBL/GenBank Feature Table Definition” (http://www.ncbi.nlm.nih.gov/collab/FT/index.html).
  • the start position number corresponds to the first letter of “ATG” that is the nucleotide triplet encoding methionine; the termination position number corresponds to the third letter of the stop codon.
  • BRACE20027520 123 613 . . . 1215 1762 BRACE20027550 124 168 . . . 578 1763 BRACE20027720 125 169 . . . 777 1764 BRACE20027920 126 105 . . . 1496 1765 BRACE20027960 127 1731 . . . 2132 1766 BRACE20028120 128 408 . . . 917 1767 BRACE20028600 129 784 . . . 1593 1768 BRACE20028610 130 774 . . . 1196 1769 BRACE20028960 131 63 . . .
  • CTONG20003030 262 2228 . . . 2641 1901 CTONG20005890 263 294 . . . 3017 1902 CTONG20007710 264 1088 . . . 1468 1903 CTONG20008270 265 863 . . . 2080 1904 CTONG20011390 266 50 . . . 3337 1905 CTONG20013200 267 123 . . . 1823 1906 CTONG20013660 268 3 . . . 1571 1907 CTONG20015330 269 87 . . . 527 1908 CTONG20018200 270 42 . . . >3217 1909 CTONG20019110 271 511 . . .
  • CTONG20029650 282 118 . . . >2551 1921 CTONG20037820 283 332 . . . 895 1922 CTONG20047160 284 113 . . . 1021 1923 CTONG20055530 285 63 . . . >2305 1924 CTONG20064490 286 1533 . . . 1859 1925 D3OST20001840 287 77 . . . 1429 1926 DFNES20002120 288 1263 . . . 1940 1927 DFNES20002680 289 505 . . . 2571 1928 DFNES20002920 290 52 . . . 639 1929 DFNES20003350 291 33 . . .
  • FCBBF10005980 1517 . . . 1849 1931 FCBBF10005980 293 375 . . . 2141 1932 FCBBF10006180 294 1161 . . . 1463 1933 FCBBF10006750 295 106 . . . 1023 1934 FCBBF10006860 296 521 . . . 865 1935 FCBBF10006870 297 410 . . . 1831 1936 FCBBF10006910 298 111 . . . 482 1937 FCBBF10007320 299 1236 . . . 1850 1938 FCBBF10007600 300 68 . . . 523 1939 FCBBF20000940 301 249 . . .
  • FCBBF20001050 302 29.421 1941 FCBBF20001950 303 1565 . . . 1888 1942 FCBBF20002320 304 921 . . . 2003 1943 FCBBF20002760 305 221 . . . 895 1944 FCBBF20005760 306 693 . . . 1073 1945 FCBBF20005910 307 29 . . . >2161 1946 FCBBF20006770 308 265 . . . 600 1947 FCBBF20007330 309 745 . . . 1077 1948 FCBBF20008080 310 180 . . . 821 1949 FCBBF20008150 311 641 . . .
  • FCBBF20009400 312 360 . . . 749 1951 FCBBF20009510 313 218 . . . 1333 1952 FCBBF20012110 314 136 . . . 1776 1953 FCBBF20012990 315 758 . . . 1168 1954 FCBBF20014800 316 146 . . . 1957 1955 FCBBF20015380 317 302 . . . 1246 1956 FCBBF20016720 318 51 . . . 488 1957 FCBBF20017180 319 236 . . . 598 1958 FCBBF20017200 320 2306 . . . 2767 1958 FCBBF40002820 321 207 . . .
  • IMR3220007750 511 197 . . . >1670 2150
  • IMR3220007910 512 934 . . . 1515 2151 IMR3220008380 513 228 . . . 1142 2152
  • IMR3220008590 514 756 . . . 1061 2153
  • IMR3220009530 518 2 . . . 394 2157 IMR3220009730 519 102 . . .
  • KIDNE20003490 547 219 . . . 1523 2186 KIDNE20003750 548 732 . . . 1568 2187 KIDNE20004030 549 194 . . . 3142 2188 KIDNE20004220 550 1699 . . . 2217 2189 KIDNE20004970 551 274 . . . 1479 2190 KIDNE20005130 552 404 . . . 1417 2191 KIDNE20005170 553 57 . . . 944 2192 KIDNE20005190 554 530 . . . 1045 2193 KIDNE20005740 555 32 . . .
  • KIDNE20061490 594 824 . . . 1327 2233 KIDNE20062480 595 649 . . . 963 2234 KIDNE20062990 596 72 . . . 1334 2235 KIDNE20063530 597 710 . . . 1105 2236 KIDNE20063760 598 1332 . . . 1724 2237 KIDNE20066520 599 112 . . . 435 2238 KIDNE20067600 600 677 . . . 1795 2239 KIDNE20067750 601 54 . . . 2228 2240 KIDNE20068800 602 1048 . . .
  • KIDNE20070050 603 1672 . . . 2001 2242 KIDNE20070770 604 610 . . . 1845 2243 KIDNE20071860 605 1662 . . . 1973 2244 KIDNE20073280 606 24 . . . 1898 2245 KIDNE20073520 607 332 . . . 2140 2246 KIDNE20073560 608 171 . . . 497 2247 KIDNE20074220 609 1496 . . . 1879 2248 KIDNE20075690 610 231 . . . 911 2249 KIDNE20078100 611 714 . . . 1373 2250 KIDNE20078110 612 166 .
  • NT2NE10000180 661 131 . . . 1189 2300 NT2NE10000230 662 172 . . . 483 2301 NT2NE10000630 663 175 . . . 1317 2302 NT2NE10000730 664 585 . . . 1364 2303 NT2NE10000830 665 556 . . . 1179 2304 NT2NE10001200 666 431 . . . 874 2305 NT2NE10001630 667 600 . . . 1013 2306 NT2NE10001850 668 23 . . . 1960 2307 NT2NE20000380 669 408 . . .
  • NT2RI20089420 868 626 . . . 1099 2507 NT2RI20090650 869 41 . . . 1594 2508 NT2RI20090660 870 65 . . . 1852 2509 NT2RI20090830 871 988 . . . 1713 2510 NT2RI20091440 872 216 . . . 1037 2511 NT2RI20092150 873 574 . . . >2918 2512 NT2RI20092890 874 651 . . . 2471 2513 NT2RI20094060 875 17 . . . 1030 2514 NT2RP60000080 876 2249 . . .
  • NT2RP70092590 1003 148 . . . 2256 2642 NT2RP70093220 1004 333 . . . 2783 2643 NT2RP70093630 1005 1372 . . . 1710 2644 NT2RP70093700 1006 124 . . . 2220 2645 NT2RP70093730 1007 212 . . . 2389 2646 NT2RP70093940 1008 135 . . . 2909 2647 NT2RP70093970 1009 830 . . . 1705 2648 NT2RP70094290 1010 705 . . . 1046 2649 NT2RP70094660 1011 76 . .
  • PLACE60004240 1105 243 . . . 845 2744 PLACE60004290 1106 1792 . . . 2154 2745 PLACE60005230 1107 449 . . . 994 2746 PLACE60005500 1108 447 . . . 791 2747 PLACE60005550 1109 140 . . . 631 2748 PLACE60009530 1110 8 . . . 337 2749 PLACE60012810 1111 76 . . . 2601 2750 PLACE60012940 1112 159 . . . 587 2751 PLACE60014430 1113 215 . . . 1816 2752 PLACE60018860 1114 94 . . .
  • PROST10003430 1155 259 . . . 2445 2794
  • PROST10005260 1156 1214 . . . 1591 2795
  • PROST10005360 1157 240 . . . 2477
  • PROST10005640 1158 139 . . . 525 2797
  • PROST20000360 1159 1580 . . . 1969
  • 2798 PROST20000530 1160 1439 . . . 1825 2799
  • PROST20002060 1072 . . . 1506 2801
  • PROST20002670 1163 547 . . . 897 2802
  • PROST20002730 1164 1070 . . .
  • PROST20002740 1165 1557 . . . 1910
  • PROST20003250 1166 96 . . . 965
  • PROST20004630 1167 495 . . . 815
  • PROST20017390 1168 122 . . . 505
  • PROST20017960 1169 1401 . . . 1829
  • PROST20018230 1170 89 . . . 1447
  • PROST20018990 1171 2024 . . . 2953 2810
  • PROST20019980 1172 1544 . . . 1852
  • PROST20021620 1173 1439 . . . 1918
  • PROST20023380 1174 11 . . .
  • PROST20033380 1185 19 . . . 1524 2824 PROST20033400 1186 294 . . . 647 2825 PROST20034720 1187 280 . . . 1764 2826 PROST20037320 1188 1001 . . . 1414 2827 PROST20039220 1189 1790 . . . 2416 2828 PROST20043320 1190 278 . . . 1843 2829 PROST20044160 1191 435 . . . 866 2830 PROST20044810 1192 1442 . . . 1759 2831 PROST20051210 1193 405 . . . 1217 2832 PROST20051430 1194 76 . . .
  • TESTI10001630 1361 249 . . . 1298 3000 TESTI10001680 1362 134 . . . 1390 3001 TESTI10001790 1363 1577 . . . 1936 3002 TESTI10001910 1364 935 . . . 1786 3003 TESTI20000180 1365 234 . . . 563 3004 TESTI20000440 1366 166 . . . 2238 3005 TESTI20001200 1367 664 . . . 1059 3006 TESTI20001540 1368 230 . . . 1684 3007 TESTI20001770 1369 1209 . . .
  • primers used to synthesize polynucleotides can be designed based on the nucleotide sequences of polynucleotides of the present invention shown in SEQ ID NOs in the above Table 1.
  • an oligo dT primer can be used as the 3′-end primer.
  • the length of the primers is usually 15-100 bp, and favorably between 15-35 bp. In case of LA PCR, which is described below, the primer length of 25-35 bp may provide a good result.
  • a method to design a primer that enables a specific amplification based on the aimed nucleotide sequence is known to those skilled in the art (Current Protocols in Molecular Biology, Ausubel et al. edit, (1987) John Wiley & Sons, Section 6.1-6.4).
  • the primer is designed so as that, in principle, the amplification products will include the translation start site. Accordingly, for example, when the 5′-end primer is designed based on the nucleotide sequence of 5′ untranslated region (5′UTR), any part of the 5′-end, which ensures the specificity to the cDNA of interest, can be selected as the primer.
  • the target nucleotide sequence to be amplified can extend to several thousand bp in some cDNA.
  • LA PCR Long and Accurate PCR
  • LA PCR in which a special DNA polymerase having 3′->5′ exonuclease activity is used, misincorporated nucleotides can be removed. Accordingly, accurate synthesis of the complementary strand can be achieved even with a long nucleotide sequence.
  • a template DNA for synthesizing the full-length cDNA of the present invention can be obtained by using cDNA libraries that are prepared by various methods.
  • the full-length cDNA clones of the present invention are clones with high probability of completeness in length, which were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the very high fullness ratio by oligo-capping, and [2] assembling the 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • primers designed based on the full-length nucleotide sequences provided by the present invention enable easily obtaining full-length cDNAs without such a special technique.
  • the problem with the cDNA libraries prepared by the known methods or commercially available is that mRNA contained in the libraries has very low fullness ratio. Thus, it is difficult to screen full-length cDNA clone directly from the library using ordinary cloning methods.
  • the present invention has revealed a nucleotide sequence of novel full-length cDNA. If a full-length nucleotide sequence is provided, it is possible to synthesize a target full-length cDNA by using enzymatic reactions such as PCR. In particular, a full-length-enriched cDNA library, synthesized by methods such as oligo-capping, is desirable to synthesize a full-length cDNA with more reliability.
  • the 5′-end sequence of the full-length cDNA clones of the invention can be used to isolate the regulatory element of transcription including the promoter on the genome.
  • a rough draft of the human genome analysis of human genomic sequence with lower accuracy
  • analysis of the entire human genomic sequence is going to be finished.
  • the polypeptide encoded by the full-length cDNA of the invention can be prepared as a recombinant polypeptide or as a natural polypeptide.
  • the recombinant polypeptide can be prepared by inserting the polynucleotide encoding the polypeptide of the invention into a vector, introducing the vector into an appropriate host cell and purifying the polypeptide expressed within the transformed host cell, as described below.
  • the natural polypeptide can be prepared, for example, by utilizing an affinity column to which an antibody against the polypeptide of the invention (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 16.1-16.19) is attached.
  • the antibody used for affinity purification may be either a polyclonal antibody, or a monoclonal antibody.
  • in vitro translation See, for example, “On the fidelity of mRNA translation in the nuclease-treated rabbit reticulocyte lysate system.” Dasso M. C., and Jackson R. J. (1989) Nucleic Acids Res. 17: 3129-3144) may be used for preparing the polypeptide of the invention.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared based on the activities, which were clarified in the above-mentioned manner, of the polypeptides of the present invention. Using the biological activity possessed by the polypeptide of the invention as an index, it is possible to verify whether or not a particular polypeptide is functionally equivalent to the polypeptide of the invention by examining whether or not the polypeptide has said activity.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared by those skilled in the art, for example, by using a method for introducing mutations into an amino acid sequence of a polypeptide (for example, site-directed mutagenesis (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 8.1-8.5) Besides, such polypeptides can be generated by spontaneous mutations.
  • the present invention also includes a polypeptide comprising the amino acid sequence shown in Table 1 in which one or more amino acids are substituted, deleted, inserted, and/or added, as long as the polypeptides have the equivalent functions to those of the polypeptides identified in the present Examples described later.
  • substitution of one or more amino acids includes substitution of several amino acids.
  • severeal amino acids means, for example, 5 amino acids, preferably 4 or 3 amino acids, more preferably 2 amino acids, and further preferably 1 amino acid.
  • a substituted amino acid has a similar property to that of the original amino acid.
  • Ala, Val, Leu, Ile, Pro, Met, Phe and Trp are assumed to have similar properties to one another because they are all classified into a group of non-polar amino acids.
  • substitution can be performed among non-charged amino acid such as Gly, Ser, Thr, Cys, Tyr, Asn, and Gln, acidic amino acids such as Asp and Glu, and basic amino acids such as Lys, Arg, and His.
  • polypeptides functionally equivalent to the polypeptides of the present invention can be isolated by using techniques of hybridization or gene amplification known to those skilled in the art. Specifically, using the hybridization technique (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.3-6.4)), those skilled in the art can usually isolate a polynucleotide highly homologous to the polynucleotide encoding the polypeptide identified in the present Example based on the identified nucleotide sequence (Table 1) or a portion thereof and obtain the functionally equivalent polypeptide from the isolated polynucleotide.
  • the present invention include polypeptides encoded by the polynucleotides hybridizing with the polynucleotides encoding the polypeptides identified in the present Example, as long as the polypeptides are functionally equivalent to the polypeptides identified in the present Example.
  • Organisms from which the functionally equivalent polypeptides are isolated are illustrated by vertebrates such as human, mouse, rat, rabbit, pig and bovine, but are not limited to these animals.
  • Washing conditions of hybridization for the isolation of polynucleotides encoding the functionally equivalent polypeptides are usually “1 ⁇ SSC, 0.1% SDS, 37° C.”; more stringent conditions are “0.5 ⁇ SSC, 0.1% SDS, 42° C.”; and still more stringent conditions are “0.1 ⁇ SSC, 0.1% SDS, 65° C.”.
  • the following conditions can be given as hybridization conditions of the present invention. Namely, conditions in which the hybridization is done at “6 ⁇ SSC, 40% Formamide, 25° C.”, and the washing at “1 ⁇ SSC, 55° C.” can be given.
  • More preferable conditions are those in which the hybridization is done at “6 ⁇ SSC, 40% Formamide, 37° C.”, and the washing at “0.2 ⁇ SSC, 55° C.”. Even more preferable are those in which the hybridization is done at “6 ⁇ SSC, 50% Formamide, 37° C.”, and the washing at “0.1 ⁇ SSC, 62° C.”.
  • the more stringent the conditions of hybridization are the more frequently the polynucleotides highly homologous to the probe sequence are isolated. Therefore, it is preferable to conduct hybridization under stringent conditions.
  • stringent conditions in the present invention are, washing conditions of “0.5 ⁇ SSC, 0.1% SDS, 42° C.”, or alternatively, hybridization conditions of “6 ⁇ SSC, 40% Formamide, 37° C.”, and the washing at “0.2 ⁇ SSC, 55° C.”.
  • One skilled in the art can suitably select various conditions, such as dilution ratios of SSC, formamide concentrations, and temperatures to accomplish a similar stringency.
  • the amino acid sequences of polypeptides isolated by using the hybridization techniques usually have high identity to those of the polypeptides of the present invention, which are shown in Table 1.
  • the present invention encompasses a polynucleotide comprising a nucleotide sequence that has a high identity to the nucleotide sequence of claim 1 (a).
  • the present invention encompasses a peptide, or polypeptide comprising an amino acid sequence that has a high identity to the amino acid sequence encoded by the polynucleotide of claim 1 (b).
  • the term “high identity” indicates sequence identity of at least 40% or more; preferably 60% or more; and more preferably 70% or more. Alternatively, more preferable is identity of 90% or more, or 93% or more, or 95% or more, furthermore, 97% or more, or 99% or more.
  • the identity can be determined by using the BLAST search algorithm.
  • the present invention also provides a polynucleotide containing at least 15 nucleotides complementary to a polynucleotide comprising a nucleotide sequence of SEQ ID NOs shown in Table 1 or the complementary strand thereof.
  • complementary strand is defined as one strand of a double strand DNA composed of A:T and G:C base pair to the other strand.
  • complementary is defined as not only those completely matching within a continuous region of at least 15 nucleotides, but also having a identity of at least 70%, favorably 80% or higher, more favorably 90% or higher, and most favorably 95% or higher within that region. The identity may be determined using the algorithm described herein.
  • Such a polynucleotide includes probes and primers used for the detection and amplification of a polynucleotide encoding the inventive polypeptide.
  • the polynucleotide When used as a primer, the polynucleotide usually comprises 15 to 100 bp, and preferably of 15 to 35 bp.
  • the polynucleotide When used as a probe, the polynucleotide comprises the whole or a part of the sequence of a polynucleotide of the invention, and comprises at least 15 bp.
  • primers such polynucleotides are complementary at the 3′-end, and restriction enzyme recognition sequences or tags can be added to the 5′-end.
  • polynucleotides of the present invention include an antisense polynucleotide for suppressing the expression of a polypeptide of the invention, which comprises an amino acid sequence of SEQ ID NOs shown in Table 1.
  • an antisense polynucleotide has at least 15 bp or more, for example 50 bp or more, preferably 100 bp or more, and more preferably 500 bp or more, and usually has 3000 bp or less, and preferably 2000 bp or less.
  • Antisense polynucleotides can be used in the gene therapy of diseases caused by abnormalities of the polypeptides of the invention (abnormal function or abnormal expression).
  • An antisense polynucleotide can be prepared, for example, by the phosphorothioate method (“Physicochemical properties of phosphorothioate oligodeoxynucleotides.” Stein (1988) Nucleic Acids Res. 16: 3209-3221) based on the sequence information of polynucleotide encoding a polypeptide of the invention (for example, the nucleotide sequences of SEQ ID NO: 1 to 1639).
  • the polynucleotides or antisense polynucleotides of the present invention can be used in, for example, gene therapy.
  • target diseases for example, cancers or various inflammatory diseases may be preferable.
  • These molecules can be used for gene therapy, for example, by administrating them to patients by the in vivo or ex vivo method using virus vectors such as retrovirus vectors, adenovirus vectors, and adeno-related virus vectors, or non-virus vectors such as liposomes.
  • the present invention also includes a partial peptide of the polypeptides of the invention.
  • the partial peptide comprises a polypeptide generated as a result that a signal peptide has been removed from a secretory protein. If the polypeptide of the present invention has an activity as a receptor or a ligand, the partial peptide may function as a competitive inhibitor of the polypeptide and may bind to the receptor (or ligand).
  • the present invention includes an antigen peptide for raising antibodies.
  • the peptides comprise at least 7 amino acids, preferably 8 amino acids or more, more preferably 9 amino acids or more, and even more preferably 10 amino acids or more.
  • the peptide can be used for preparing antibodies against the polypeptide of the invention, or competitive inhibitors of them, and also screening for a receptor that binds to the polypeptide of the invention.
  • the partial peptides of the invention can be produced, for example, by genetic engineering methods, known methods for synthesizing peptides, or digesting the polypeptide of the invention with an appropriate peptidase.
  • the present invention also relates to a vector into which a polynucleotide of the invention is inserted.
  • the vector of the invention is not limited as long as it contains the inserted polynucleotide stably.
  • vectors such as pBluescript vector (Stratagene) are preferable as a cloning vector.
  • expression vectors are especially useful. Any expression vector can be used as long as it is capable of expressing the polypeptide in vitro, in E. coli , in cultured cells, or in vivo.
  • pBEST vector Promega
  • pET vector Invitrogen
  • ligation utilizing restriction sites can be performed according to the standard method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • GATEWAYTM is an expression vector construction system for polypeptide expression
  • This system includes two types of site-specific recombinases (BP CLONASETM and LR CLONASETM) derived from lambda phage and uses BP CLONASETM-specific recombination sites for an Entry Vector and LR CLONASETM-specific recombination sites for a Destination Vector, which may comprise a tag useful for polypeptide purification.
  • BP CLONASETM and LR CLONASETM site-specific recombinases
  • a polynucleotide fragment of interest is inserted into the entry vector using the first recombination. Then, the secondary recombination is allowed to take place between the entry vector, where the polynucleotide fragment of interest has been inserted, and the destination vector.
  • the expression vector can be prepared rapidly and highly efficiently.
  • the step of expression vector construction and expression of polypeptide of interest takes about 7 to 10 days.
  • the polypeptide of interest can be expressed and prepared in only 3 to 4 days. Thus, the system ensures a high-throughput functional analysis for expressed polypeptides (http://biotech.nikkeibp.co.jp/netlink/lto/gateway/).
  • the present invention also relates to a transformant carrying the vector of the invention.
  • Any cell can be used as a host into which the vector of the invention is inserted, and various kinds of host cells can be used depending on the purposes.
  • COS cells or CHO cells can be used, for example.
  • Introduction of the vector into host cells can be performed, for example, by calcium phosphate precipitation method, electroporation method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 9.1-9.9), lipofectamine method (GIBCO-BRL), or microinjection method, etc.
  • a polynucleotide containing at least 15 nucleotides comprising a nucleotide sequence of any one of the polynucleotides comprising the nucleotide sequences of SEQ ID NOs shown in Table 1 or the complementary strand thereof can be used not only as a primer for synthesizing full-length cDNAs but also for testing and diagnosing the abnormalities of the polypeptide encoded by the full-length cDNA of the present invention.
  • polymerase chain reaction genomic DNA-PCR, or RT-PCR
  • the obtained genomic region can be used for detection and/or diagnosis of the abnormality of the sequence by RFLP analysis, SSCP, or sequencing.
  • analysis of the amount of expression of the mRNA using the polynucleotide of the present invention as a probe or a primer enables detection and diagnosis of the disease.
  • the present invention also relates to antibodies that bind to the polypeptide of the invention.
  • antibodies that bind to the polypeptide of the invention There are no limitations in the form of the antibodies of the invention. They include polyclonal antibodies, monoclonal antibodies, or their portions that can bind to an antigen. They also include antibodies of all classes. Furthermore, special antibodies such as humanized antibodies and chimeric antibodies are also included.
  • the polyclonal antibody of the invention can be obtained according to the standard method by synthesizing an oligopeptide corresponding to the amino acid sequence and immunizing rabbits with the peptide (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.12-11.13).
  • the monoclonal antibody of the invention can be obtained according to the standard method by purifying the polypeptide expressed in E. coli , immunizing mice with the polypeptide, and producing a hybridoma cell by fusing the spleen cells and myeloma cells (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • the antibody binding to the polypeptide of the present invention can be used for purification of the polypeptide of the invention, and also for detection and/or diagnosis of the abnormalities of the expression and structure of the polypeptide.
  • polypeptides can be extracted, for example, from tissues, blood, or cells, and the polypeptide of the invention is detected by Western blotting, immunoprecipitation, or ELISA, etc. for the above purpose.
  • the antibody binding to the polypeptide of the present invention can be utilized for treating the diseases that associates with the polypeptide of the invention.
  • human antibodies, humanized antibodies, or chimeric antibodies are preferable in terms of their low antigenicity.
  • the human antibodies can be prepared by immunizing a mouse whose immune system is replaced with that of human (e.g., see “Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice” Mendez, M. J. et al. (1997) Nat. Genet. 15: 146-156).
  • the humanized antibodies can be prepared by recombination of the hypervariable region of a monoclonal antibody (Methods in Enzymology (1991) 203: 99-121).
  • the use of the amino acid sequences of the polypeptides encoded by the cDNAs of the present invention enables predicting that the polypeptides have the following functions. It can be predict, from the results of homology search of SwissProt, GenBank, UniGene, or nr, that these polypeptides have such functions. Specifically, for instance, as shown in Examples, searching for a known gene or polypeptide that is homologous to the partial sequence of the full-length cDNA of the invention (1639 clone) and referring the function of the gene and of the polypeptide encoded by the gene make it possible to predict the function of the polypeptide encoded by the cDNA of the invention. In this way, each of 892 clones out of the 1639 full-length cDNA clones of the invention was predicted to encode a polypeptide that was classified into the following categories.
  • Enzyme and/or metabolism-related protein (168 clones)
  • Protein synthesis- and/or transport-related protein (24 clones)
  • DNA- and/or RNA-binding protein (158 clones)
  • the functions of the polypeptides encoded by the cDNAs of the present invention can be predicted by assessing the presence of signal sequence, transmembrane region, nuclear translocation signal, glycosylation signal, phosphorylation site, and zinc finger motif, SH3 domain, etc. in the amino acid sequences.
  • Biochemistry 33: 3038-3049 can be used to predict the existence of the signal sequence or transmembrane region.
  • a partial amino acid sequence of the polypeptide is fused with another polypeptide such as GFP, the fusion polypeptide is transfected into cultured cells, and the localization is analyzed to predict the function of the original polypeptide.
  • the functions are often predictable by using partial sequence information (preferably 300 nucleotides or more) instead of the full-length nucleotide sequences.
  • partial sequence information preferably 300 nucleotides or more
  • the result of the prediction by using partial nucleotide sequence does not always agree with the result obtained by using full-length nucleotide sequence, and thus, it is needless to say that the prediction of function is preferably performed based on the full-length nucleotide sequences.
  • GenBank, Swiss-Prot, UniGene and nr databases were searched for homologies of the full-length nucleotide sequences of the 1639 clones (see Example 6).
  • the amino acid sequences deduced from the full-length nucleotide sequences were searched for functional domains by PSORT, SOSUI and Pfam. Prediction of functions of polypeptides encoded by the clones and the categorization thereof were performed based on these results obtained.
  • the categorization was carried out by the following method.
  • the cDNA clones were classified into the above-mentioned 14 functional categories based on the results of annotation-based categorization (using the keywords in the case of Swiss-Prot hit data; using Definition or Reference information in the case of GenBank, UniGene, or nr hit data), and the signal sequence search of the deduced ORFs by PSORT and the transmembrane region search by SOSUI.
  • the following 168 clones presumably belong to the category of enzymes and/or metabolism-related proteins.
  • the following 23 clones presumably belong to the category of cell division- and/or cell proliferation-related proteins.
  • the following 60 clones presumably belong to the category of cytoskeleton-related proteins.
  • BRACE20078680 FEBRA20075510, IMR3220008380, KIDNE20005190, KIDNE20050420, MESAN20002910, NB9N410001350, NT2NE20005360, NT2RI20032050, NT2RI20032220, NT2RP70000760, NT2RP70076430, NT2RP70093940, OCBBF20008240, PLACE50000580, PROST20000530, SKMUS20000740, SKMUS20008630, TESTI20007840, TESTI20015120, TESTI20018690, TESTI20078720, THYMU10005580, UMVEN20001330
  • BRACE20014550 NT2RI20037510, NT2RI20053350, NT2RP70029060, NT2RP70062960, PLACE50001700
  • the following 19 clones presumably belong to the category of development and/or differentiation-related proteins.
  • BGGI120006930 CTONG20028200, FCBBF50002610, FEBRA20014920, FEBRA20017150, FEBRA20060920, MAMGL10001820, NESOP10000870, NHNPC10001240, NT2RI20078790, NT2RP70008120, NT2RP70018560, NT2RP70045410, OCBBF20002770, SALGL10000650, SMINT10001000, TESTI10000550, TESTI20026760, TESTI20078140
  • the following 158 clones presumably belong to the category of DNA- and/or RNA-binding proteins.
  • the following 63 clones presumably belong to the category of ATP- and/or GTP-binding proteins.
  • NTONG10001300 is a clone which was predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • the three clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
  • BRACE20080970 BRACE20092120, BRAWH10001300, FEBRA20019890, KIDNE20031850, KIDNE20060140, MESAN20000920, NB9N410000470, NT2RI20071480, NT2RI20078910, NT2RP70088550, NTONG20016120, OCBBF10000910, PROST20094830, SKNSH10003010, SPLEN20002670, TESTI20031960, TESTI20036250, TESTI20037810, TESTI20083870, TESTI20177400
  • the 21 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • the 29 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
  • the 43 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • the 1 clone shown above is a clone which was predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • the 2 clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • the 34 clones shown above are clones which were predicted to highly possibly belong to the category of DNA- and/or RNA-binding protein based on the result of domain search by Pfam.
  • the 1 clone shown above is a clone which was predicted to highly possibly belong to the category of ATP- and/or GTP-binding proteins based on the result of domain search by Pfam.
  • the 185 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search using their full-length nucleotide sequences and motif search in their estimated ORFs.
  • a polypeptide does not always belong solely to a single category of the above-described functional categories, and therefore, a polypeptide may belong to any of the predicted functional categories.
  • additional functions can be found for the clones classified into these functional categories by further analyses.
  • polypeptide encoded by clones of the invention contains full-length amino acid sequence, it is possible to analyze its biological activity, and its effect on cellular conditions such as cell proliferation and differentiation by expressing the polypeptide as a recombinant polypeptide using an appropriate expression system, injecting the recombinant into the cell, or raising a specific antibody against the polypeptide.
  • the clone predicted to belong to the category of secretory and/or membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it was a secretory or membrane protein, or a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane region was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • some annotation such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc.
  • the clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • the clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • the clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • the clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, UniGene, or nr, where the hit data corresponds to genes or polypeptides which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database described later.
  • OMIM Online Mendelian Inheritance in Man
  • the clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • the clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • the clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • the clone predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • the clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • the clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • the clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • the clone predicted to belong to the category of DNA- and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • the clone predicted to belong to the category of ATP- and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • a protein involved in a disease it is possible to perform a functional analysis as described above, but also possible to analyze correlation between the expression or the activity of the protein and a certain disease by using a specific antibody that is obtained by using expressed protein.
  • the database OMIM which is a database of human genes and diseases, to analyze the protein. Further, new information is constantly being deposited in the OMIM database. Therefore, it is possible for one skilled in the art to find a new relationship between a particular disease and a gene of the present invention in the most up-to-date database.
  • the proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • nucleotide sequences of cDNAs of the present invention enables analyzing the expression frequency of genes corresponding to the cDNAs.
  • functions of the genes can be predicted based on the information obtained by the expression frequency analysis.
  • BODYMAP there is a database called “BODYMAP”; gene clones are extracted at random from cDNA libraries of various tissues and/or cells, and the clones homologous to one another are assigned to a single cluster based on the information of nucleotide sequence homology at the 3′-end; genes are classified into any clusters, and the numbers of clones in the respective clusters are compared to gain the information on expression frequency (http://bodymap.ims.u-tokyo.ac.jp/).
  • genes involved in particular pathology or functions were selected by the use of databases shown below (see Example 7; “Expression frequency analysis in silico”).
  • the database used in the analyses of the present invention contains nucleotide sequences of 770,546 clones, and the population of the database is large enough for the analysis.
  • the sequence information in the database was obtained by selecting cDNA clones at random from cDNA libraries derived from the various tissues and cells shown in Example 1 and determining the 5′-end sequences thereof.
  • nucleotide sequences of respective clones in this database were categorized (clustered) based on the nucleotide sequence homology determined with a search program; the number of clones belonging to every cluster of each library was determined and normalized; thus, the ratio of a certain gene in a cDNA library was determined.
  • This analysis provided the information of the expression frequency of a gene in a tissue or cell that is the source of the cDNA library.
  • the libraries from the tissues or cells, which had been used in the large-scale cDNA analyses were taken as subjects to compare the expression levels between different tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues or cells from which 600 or more cDNA clones whose nucleotide sequences had been analyzed were derived. The result of this analysis showed that the cDNA clones corresponded to the genes involved in the pathology and functions, which are indicated below. Each value in Tables 3 to 39 indicated below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset correlates to the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism.
  • the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line are genes involved in bone metabolism involved in osteoporosis.
  • a nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line.
  • the result of comparative analysis for the frequency between the cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were 41 clones indicated in Table 3. These clones are involved in osteoporosis.
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • cancer tissues express a distinct set of genes, and thus the expression thereof can contribute to the carcinogenesis in tissues and cells.
  • genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • genes involved in development and differentiation which is the expression frequency analysis in which the expression levels of genes are compared between developing and/or differentiating tissues and/or cells and adult tissues and/or cells.
  • the genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • genes involved in development or differentiation of particular tissues were selected from the 1639 clones whose full-length nucleotide sequence had been revealed (see Example 7).
  • the expression frequency or the like can be analyzed by PCR based on the nucleotide sequences of cDNAs of the present invention.
  • the band intensities can be determined by ethidium bromide staining.
  • the RI signal or fluorescence intensity can be assayed for the quantity of labeled amplification products.
  • the quantity of amplification products can also be determined by measuring the RI signal or the fluorescence intensity from the RI-labeled or fluorescently labeled probe hybridizing to the products. The assay results thus obtained are compared and then the clones exhibiting differences in the expression levels can be selected.
  • PCR methods There are some quantitative PCR methods: a PCR method using internal standards; a competitive PCR, in which the quantification is achieved by adding, to a sample, a dilution series of a known quantity of a template RNA and by comparing the quantity of an amplification product derived from the RNA of interest with the quantity of an amplification product derived from the template RNA.
  • ATAC-PCR Adaptor-tagged competitive PCR
  • ATAC-PCR is a method of competitive PCR which is practiced by using multiple adapters of different sizes attached to a gene whose 3′-end nucleotide sequence has previously been determined.
  • the ratio of expression frequency of a single mRNA species from a number of tissues (cells) can be assayed in a single step (Nucleic Acids Research 1997, 25(22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112).
  • genes exhibiting tissue-specific expression are genes playing important parts in the tissue functions and, therefore, can be candidates for genes involved in diseases and/or disorders affecting the tissues.
  • inflammation is an important biological response that is known to be involved in various diseases.
  • the representative inflammation-inducing factors include TNF- ⁇ (Tumor Necrosis Factor-alpha), LPS (Lipopolysaccharides), etc.
  • TNF- ⁇ Tumor Necrosis Factor-alpha
  • LPS Lipopolysaccharides
  • Many genes have been identified as genes located downstream of the TNF- ⁇ or LPS stimulation.
  • the respective stimulations are transduced through independent pathways of signaling cascade.
  • THP-1 cell which is a human monocyte cell line, was cultured in the presence of TNF- ⁇ (Tumor Necrosis Factor-alpha) or LPS (Lipopolysaccharides).
  • TNF- ⁇ Tumor Necrosis Factor-alpha
  • LPS Lipopolysaccharides
  • the genes whose expression levels were altered owing to the presence of the agent were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of TNF- ⁇ were ADRGL10000180, BRACE20030780, BRACE20077640, BRACE20083850, BRAWH20004430, FCBBF10006180, FEBRA20003780, FEBRA20006800, FEBRA20012940, FEBRA20015840, HEART20004480, HLUNG10000370, HLUNG20001160, HSYRA20013320, IMR3220008380, KIDNE10001520, KIDNE20040540, KIDNE2006
  • the clones whose expression levels were decreased owing to the presence of TNF- ⁇ were BRACE20013400, BRACE20091880, HEART20005060, HLUNG20001760, IMR3220008590, NT2NE10001850, NT2RI20018660, NT2RI20053350, NT2RI20070480, PLACE60047380, STOMA20002890, SYNOV20001770, TRACH20001960.
  • the clones whose expression levels were increased owing to the presence of LPS were FCBBF10006180, FEBRA20015840, HLUNG10000370, HLUNG20001160, HSYRA20013320, KIDNE20040540, KIDNE20061490, NT2NE10001630, NT2NE20003920, NT2NE20005500, NT2RI20014500, NT2RI20016570, NT2RI20078270, NTONG10002570, PUAEN10003220, STOMA20002570, TESTI20011340.
  • the clones whose expression levels were decreased owing to the presence of LPS were BRACE20013400, BRACE20091880, HEART20005060, HLUNG20001760, NT2RI20070480, UMVEN20001330.
  • MKN45 which is a gastric cancer cell line
  • Hcobacter pylori The genes whose expression levels were altered owing to the presence of Helicobacter pylori were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of Helicobacter pylori were BRACE10001590, BRACE20079530, BRAWH10001620, FEBRA20006800, KIDNE20003490, KIDNE20040540, KIDNE20050420, NT2NE10001850, STOMA20002890, SYNOV20001770, TESTI10000550, UTERU20004850.
  • the clones whose expression levels were decreased owing to the presence of Helicobacter pylori were BRACE20034490, BRACE20077640, BRACE20083850, KIDNE20005170, LIVER20000330, NT2RP60000390, NTONG10000980, UMVEN20001330.
  • the polypeptide encoded by the cDNA of the present invention is a regulatory factor of cellular conditions such as growth and differentiation
  • it can be used for developing medicines as follows.
  • the polypeptide or antibody provided by the invention is injected into a certain kind of cells by microinjection. Then, using the cells, it is possible to screen low molecular weight compounds, etc. by measuring the change in the cellular conditions, or the activation or inhibition of a particular gene.
  • the screening can be performed as follows.
  • the polypeptide is expressed and purified as recombinant.
  • the purified polypeptide is microinjected into cells such as various cell lines, or primary culture cells, and the cellular change such as growth and differentiation can be examined.
  • the induction of genes whose expression is known to be involved in a particular change of cellular conditions may be detected by the amount of mRNA or polypeptide.
  • the amount of intracellular molecules (low molecular weight compounds, etc.) that is changed by the function of the gene product (polypeptide) which is known to be involved in a particular change of cellular conditions may be detected.
  • the compounds to be screened can be added to the culture media and assessed for their activity by measuring the change of the cellular conditions.
  • cell lines introduced with the gene obtained in the invention can be used for the screening. If the gene product is turn out to be involved in a particular change in the cellular conditions, the change of the product can be used as a measurement for screening. Once a compound is screened out which can activate or inhibit the function of the polypeptide of the invention, it can be applied for developing medicines.
  • polypeptide encoded by the cDNA of the present invention is a secretory protein, membrane protein, or protein involved in signal transduction, glycoprotein, transcription, or diseases, it can be used in functional assays for developing medicines.
  • a membrane protein In case of a membrane protein, it is most likely to be a polypeptide that functions as a receptor or ligand on the cell surface. Therefore, it is possible to reveal a new relationship between a ligand and receptor by screening the membrane protein of the invention based on the binding activity with the known ligand or receptor. Screening can be performed according to the known methods.
  • a ligand against the polypeptide of the invention can be screened in the following manner. Namely, a ligand that binds to a specific polypeptide can be screened by a method comprising the steps of: (a) contacting a test sample with the polypeptide of the invention or a partial peptide thereof, or cells expressing these, and (b) selecting a test sample that binds to said polypeptide, said partial peptide, or said cells.
  • screening using cells expressing the polypeptide of the present invention that is a receptor protein can also be performed as follows. It is possible to screen receptors that is capable of binding to a specific polypeptide by using procedures (a) attaching the sample cells to the polypeptide of the invention or its partial peptide, and (b) selecting cells that can bind to the said polypeptide or its partial peptide.
  • the polypeptide of the invention is expressed, and the recombinant polypeptide is purified.
  • the purified polypeptide is labeled, binding assay is performed using a various cell lines or primary cultured cells, and cells that are expressing a receptor are selected (Growth and differentiation factors and their receptors, Shin-Seikagaku Jikken Kouza Vol. 7 (1991) Honjyo, Arai, Taniguchi, and Muramatsu edit, p 203-236, Tokyo-Kagaku-Doujin).
  • a polypeptide of the invention can be labeled with RI such as 125 I, and enzyme (alkaline phosphatase etc.).
  • a polypeptide of the invention may be used without labeling and then detected by using a labeled antibody against the polypeptide.
  • the cells that are selected by the above screening methods, which express a receptor of the polypeptide of the invention, can be used for the further screening of an agonists or antagonists of the said receptor.
  • the receptor of the polypeptide of the invention or the cells expressing the receptor are obtained by screening, it is possible to screen a compound that binds to the ligand and receptor. Also it is possible to screen a compound that can inhibit both bindings (agonists or antagonists of the receptor, for example) by utilizing the binding activities.
  • the screening method comprises the steps of (a) contacting the polypeptide of the invention or cells expressing the polypeptide of the invention with the ligand, in the presence of a test sample, (b) detecting the binding activity between said polypeptide or cells expressing said polypeptide and the ligand, and (c) selecting a compound that reduces said binding activity when compared to the activity in the absence of the test sample.
  • the screening method comprises the steps of (a) contacting the polypeptide of the invention with its receptor or cells expressing the receptor in the presence of samples, (b) detecting the binding activity between the polypeptide and its receptor or the cells expressing the receptor, and (c) selecting a compound that can potentially reduce the binding activity compared to the activity in the absence of the sample.
  • Samples to screen include cell extracts, expressed products from a gene library, synthesized low molecular compound, synthesized peptide, and natural compounds, for example, but are not construed to be listed here.
  • a compound that is isolated by the above screening using a binding activity of the polypeptide of the invention can also be used as a sample.
  • a compound isolated by the screening may be a candidate to be an agonist or an antagonist of the receptor of the polypeptide.
  • an assay that monitors a change in the intracellular signaling such as phosphorylation which results from reduction of the binding between the polypeptide and its receptor, it is possible to identify whether the obtained compound is an agonist or antagonist of the receptor.
  • the compound may be a candidate of a molecule that can inhibit the interaction between the polypeptide and its associated proteins (including a receptor) in vivo. Such compounds can be used for developing drugs for precaution or cures of a disease in which the polypeptide is involved.
  • Secretory proteins may regulate cellular conditions such as growth and differentiation. It is possible to find out a novel factor that regulates cellular conditions by adding the secretory protein of the invention to a certain kind of cell, and performing a screening by utilizing the cellular changes in growth or differentiation, or activation of a particular gene.
  • the screening can be performed, for example, as follows. First, the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts of mRNA and polypeptide. Alternatively, the amount of an intracellular molecule (low-molecular-weight compounds, etc.) that is changed by the function of a gene product (polypeptide) that is known to function in a certain cellular change is used for the detection.
  • the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts
  • the polypeptide of the invention can regulate cellular conditions or the functions, it is possible to apply the polypeptide as a pharmaceutical and diagnostic medicine for related diseases by itself or by altering a part of it into an appropriate composition.
  • the secretory protein provided by the invention may be used to explore a novel ligand-receptor interaction using a screening based on the binding activity to a known ligand or receptor.
  • a similar method can be used to identify an agonist or antagonist.
  • the resulting compounds obtained by the methods can be a candidate of a compound that can inhibit the interaction between the polypeptide of the invention and an interacting molecule (including a receptor).
  • the compounds may be able to use as a preventive, therapeutic, and diagnostic medicine for the diseases, in which the polypeptide may play a certain role.
  • Proteins involved in signal transduction or transcription may be a factor that affects a certain polypeptide or gene in response to intracellular/extracellular stimuli. It is possible to find out a novel factor that can affect a polypeptide or gene by expressing the polypeptide provided by the invention in a certain types of cells, and performing a screening utilizing the activation of a certain intracellular polypeptide or gene.
  • the change of the expression of a certain gene can be detected by introducing a fusion gene that comprises a regulatory region of the gene and a marker gene (luciferase, ⁇ -galactosidase, etc.) into a cell, expressing the polypeptide provided by the invention into the cell, and estimating the activity of a marker gene product (polypeptide).
  • a marker gene luciferase, ⁇ -galactosidase, etc.
  • polypeptide or gene of the invention is involved in diseases, it is possible to screen a gene or compound that can regulate its expression and/or activity either directly or indirectly by utilizing the polypeptide of the present invention.
  • the polypeptide of the invention is expressed and purified as a recombinant polypeptide. Then, the polypeptide or gene that interacts with the polypeptide of the invention is purified, and screened based on the binding. Alternatively, the screening can be performed by adding with a compound of a candidate of the inhibitor added in advance and monitoring the change of binding activity.
  • a transcription regulatory region locating in the 5′-upstream of the gene encoding the polypeptide of the invention that is capable of regulating the expression of other genes is obtained, and fused with a marker gene. The fusion is introduced into a cell, and the cell is added with compounds to explore a regulatory factor of the expression of the said gene.
  • the compound obtained by the screening can be used for developing pharmaceutical and diagnostic medicines for the diseases in which the polypeptide of the present invention is involved.
  • the regulatory factor obtained in the screening is turn out to be a polypeptide
  • compounds that can newly affect the expression or activity of the polypeptide may be used as a medicine for the diseases in which the polypeptide of the invention is involved.
  • the polypeptide of the invention has an enzymatic activity, regardless as to whether it is a secretory protein, membrane protein, or proteins involved in signal transduction, glycoprotein, transcription, or diseases, a screening may be performed by adding a compound to the polypeptide of the invention and monitoring the change of the compound.
  • the enzymatic activity may also be utilized to screen a compound that can inhibit the activity of the polypeptide.
  • the polypeptide of the invention is expressed and the recombinant polypeptide is purified. Then, compounds are contacted with the purified polypeptide, and the amount of the compound and the reaction products is examined. Alternatively, compounds that are candidates of an inhibitor are pretreated, then a compound (substrate) that can react with the purified polypeptide is added, and the amount of the substrate and the reaction products is examined.
  • the compounds obtained in the screening may be used as a medicine for diseases in which the polypeptide of the invention is involved. Also they can be applied for tests that examine whether the polypeptide of the invention functions normally in vivo.
  • the secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein of the present invention is a novel protein involved in diseases or not is determined in another method than described above, by obtaining a specific antibody against the polypeptide of the invention, and examining the relationship between the expression or activity of the polypeptide and a certain disease. In an alternative way, it may be analyzed referred to the methods in “Molecular Diagnosis of Genetic Diseases” (Elles R. edit, (1996) in the series of “Method in Molecular Biology” (Humana Press).
  • Proteins involved in diseases are targets of screening as mentioned, and thus are very useful in developing drugs which regulate their expression and activity. Also, the proteins are useful in the medicinal industry as a diagnostic marker of the related disease or a target of gene therapy.
  • Compounds isolated as mentioned above can be administered patients as it is, or after formulated into a pharmaceutical composition according to the known methods.
  • a pharmaceutically acceptable carrier or vehicle specifically sterilized water, saline, plant oil, emulsifier, or suspending agent can be mixed with the compounds appropriately.
  • the pharmaceutical compositions can be administered to patients by a method known to those skilled in the art, such as intraarterial, intravenous, or subcutaneous injections. The dosage may vary depending on the weight or age of a patient, or the method of administration, but those skilled in the art can choose an appropriate dosage properly.
  • the compound is encoded by polynucleotide, the polynucleotide can be cloned into a vector for gene therapy, and used for gene therapy.
  • the dosage of the polynucleotide and the method of its administration may vary depending on the weight or age of a patient, or the symptoms, but those skilled in the art can choose properly.
  • the present invention further relates to databases comprising at least a sequence of polynucleotide and/or polypeptide, or a medium recorded in such databases, selected from the sequence data of the nucleotide and/or the amino acids indicated in Table 1.
  • database means a set of accumulated information as machine-searchable and readable information of nucleotide sequence.
  • the databases of the present invention comprise at least one of the novel nucleotide sequences of polynucleotides provided by the present invention.
  • the databases of the present invention can consist of only the sequence data of the novel polynucleotides provided by the present invention or can comprise other information on nucleotide sequences of known full-length cDNAs or ESTs.
  • the databases of the present invention can be comprised of not only the information on the nucleotide sequences but also the information on the gene functions revealed by the present invention. Additional information such as names of DNA clones carrying the full-length cDNAs can be recorded or linked together with the sequence data in the databases.
  • the database of the present invention is useful for gaining complete gene sequence information from partial sequence information of a gene of interest.
  • the database of the present invention comprises nucleotide sequence information of full-length cDNAs. Consequently, by comparing the information in this database with the nucleotide sequence of a partial gene fragment yielded by differential display method or subtraction method, the information on the full-length nucleotide sequence of interest can be gained from the sequence of the partial fragment as a starting clue.
  • the sequence information of the full-length cDNAs constituting the database of the present invention contains not only the information on the complete sequences but also extra information on expression frequency of the genes as well as homology of the genes to known genes and known polypeptides. Thus the extra information facilitates rapid functional analyses of partial gene fragments. Further, the information on human genes is accumulated in the database of the present invention, and therefore, the database is useful for isolating a human homologue of a gene originating from other species. The human homologue can be isolated based on the nucleotide sequence of the gene from the original species.
  • gene fragments can be obtained by differential display method and subtraction method.
  • these gene fragments are utilized as tools for isolating the full-length sequences thereof.
  • the full-length sequence is easily obtained by comparing the partial sequence with the information in known databases.
  • cDNA cloning should be carried out for the full-length cDNA. It is often difficult to obtain the full-length nucleotide sequence using the partial sequence information as an initial clue. If the full-length of the gene is not available, the amino acid sequence of the polypeptide encoded by the gene remains unidentified.
  • the database of the present invention can contribute to the identification of full-length cDNAs corresponding to gene fragments, which cannot be revealed by using databases of known genes.
  • the present invention has provided 1639 polynucleotides. As has not yet proceeded the isolation of full-length cDNA within the human, the invention has great significance. It is known that secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, and so on are involved in many diseases. The genes and proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • cDNA assumed to encode secretory proteins which were provided by this invention, are very important for the industry since the encoded proteins themselves are expected to be useful as pharmaceutical agents and many disease-related genes may be included in them.
  • membrane proteins, signal transduction-related proteins, transcription-related proteins, disease-related proteins, and genes encoding them can be used as indicators for diseases, etc.
  • cDNA are also very important for the industry, which are expected to regulate the activity or expression of the encoded protein to treat diseases, etc.
  • RNAs as mRNA sources were extracted from human tissues (shown below) by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989). Further, by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989), total RNAs as mRNA sources were extracted from human culture cells and human primary culture cells (shown below) which had been cultivated by the methods described in the catalogs.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • Library name: Origin When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • NTONG Normal tongue
  • CTONG Tongue cancer
  • FCBBF Fetal brain
  • OCBBF Fetal brain
  • SYNOV Synovial membrane tissue (from rheumatioid arthritis).
  • BNGH4 H4 cells (ATCC #HTB-148);
  • IMR32 IMR32 cells (ATCC #CCL-127);
  • SKNMC SK-N-MC cells (ATCC #HTB-10);
  • 3NB69 NB69 cells (RCB #RCB0480);
  • BGGI1 GI1 cells (RCB #RCB0763);
  • NB9N4 NB9 cells (RCB #RCB0477);
  • SKNSH SK-N-SH cells (RCB #RCB0426);
  • NT2RM NT2 cells (STARATAGENE #204101);
  • NT2RP NT2 cells treated with retinoic acid (RA) for 5 weeks to induce the differentiation
  • NT2RI NT2 cells treated with RA for 5 weeks to induce the differentiation, followed by the treatment with the growth inhibitor for 2 weeks;
  • NT2NE NT2 cells were treated with RA and the growth inhibitor for the neuronal differentiation, and the resultant neurons were concentrated and harvested (NT2 Neuron);
  • NTISM NTISM: NT2 cells (STARATAGENE #204101) were treated with RA for weeks to induce the differentiation, and then treated with the growth inhibitor for 2 weeks; mRNA was prepared from the cells and a cDNA library was constructed from the mRNA; the cDNAs of the library whose nucleotide sequences were shared by those of mRNAs from undifferentiated NT2 cells were subtracted by using a Subtract Kit (Invitrogen #K4320-01); the subtracted library (NT2RI-NT2RM) was provided by this procedure.
  • RCB indicates that the cell was provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research; ATCC indicates that the cell was provided by American Type Culture Collection.
  • DFNES Normal human dermal fibroblast (neonatal skin); NHDF-Neo NHDF2564, Takara Shuzo #CC2509;
  • MESAN Normal human mesangial cell NHMC56046-2, Takara Shuzo #CC2559;
  • NHNPC Normal human neural progenitor cell NHNP5958, Takara Shuzo #CC2599;
  • PEBLM Normal human peripheral blood mononuclear cell HPBMC5939, Takara Shuzo #CC2702;
  • HSYRA Human synoviocyte HS-RA (from rheumatioid arthritis), Toyobo #T404K-05;
  • PUAEN Normal human pulmonary artery endothelial cells, Toyobo #T302K-05;
  • UMVEN Normal human umbilical vein endothelial cell HUVEC, Toyobo #T200K-05;
  • HCASM Normal human coronary artery smooth muscle cell HCASMC, Toyobo #T305K-05;
  • HCHON Normal human chondrocyte HC, Toyobo #T402K-05;
  • HHDPC Normal human dermal papilla cell HDPC, Toyobo #THPCK-001;
  • CD34C CD34+ cells (AllCells, LLC #CB14435M);
  • D3OST CD34+ cells treated with the osteoclast differentiation factor (ODF) for 3 days to induce the differentiation;
  • D6OST CD34+ cells treated with ODF for 6 days to induce the differentiation
  • D9OST CD34+ cells treated with ODF for 9 days to induce the differentiation.
  • RNAs extracted from the following human tissues were purchased and used as mRNA sources.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • ADRGL Adrenal gland, CLONTECH #64016-1;
  • BRACE Brain (cerebellum), CLONTECH #64035-1;
  • BRAWH Whole brain, CLONTECH #64020-1;
  • FEBRA Fetal brain, CLONTECH #64019-1;
  • FELIV Fetal liver, CLONTECH #64018-1;
  • HLUNG Lung, CLONTECH #64023-1;
  • KIDNE Kidney, CLONTECH #64030-1;
  • MAMGL Mammary Gland, CLONTECH #64037-1;
  • PROST Prostate, CLONTECH #64038-1;
  • SALGL Salivary Gland, CLONTECH #64026-1;
  • TCERX Cervix (Tumor), CLONTECH #64010-1;
  • TCOLN Colon (Tumor), CLONTECH #64014-1;
  • THYMU Thymus, CLONTECH #64028-1;
  • TLUNG Lung (Tumor), CLONTECH #64013-1;
  • TOVAR Ovary (Tumor), CLONTECH #64011-1;
  • ADIPS Adipose, Invitrogen #D6005-01;
  • BRALZ Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01;
  • CERVX Cervix, Invitrogen #D6047-01;
  • PERIC Pericardium, Invitrogen #D6105-01;
  • TESOP Esophageal (Tumor), Invitrogen #D6860-01;
  • TKIDN Kidney (Tumor), Invitrogen #D6870-01;
  • TLIVE Liver (Tumor), Invitrogen #D6880-01;
  • TSTOM Stomach (Tumor), Invitrogen #D6920-01;
  • FEHRT Fetal heart, STARATAGENE #738012;
  • FEKID Fetal kidney, STARATAGENE #738014;
  • FELNG Fetal lung, STARATAGENE #738020;
  • BRASW subtracted library
  • a cDNA library was constructed from mRNA prepared from tissues of cerebral cortex obtained from an Alzheimer patient [BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01]; the cDNAs of this library whose nucleotide sequences were shared by those of mRNAs from whole brain tissue [BRAWH: Whole brain, CLONTECH #64020-1] were subtracted by using a Subtract Kit (Invitrogen #K4320-01).
  • RNAs extracted and purified as poly A(+) RNAs from the human tissues shown below were purchased.
  • a cDNA library was prepared from an RNA mixture in which the poly A(+) RNA from each tissue had been combined with poly A( ⁇ ) RNA.
  • the poly A( ⁇ ) RNA was prepared by removing poly A(+) RNA from the total RNA of whole brain tissue (CLONTECH #64020-1) by using oligo dT cellulose.
  • the library names and the origins are indicated below in the order of “Library name: Origin”.
  • BRAMY Brain (amygdala), CLONTECH #6574-1;
  • BRCAN Brain (caudate nucleus), CLONTECH #6575-1;
  • BRCOC Brain (corpus callosum), CLONTECH #6577-1;
  • BRHIP Brain (hippocampus), CLONTECH #6578-1;
  • BRSSN Brain (substantia nigra), CLONTECH #6580-1;
  • BRSTN Brain (subthalamic nucleus), CLONTECH #6581-1;
  • BRTHA Brain (thalamus), CLONTECH #6582-1.
  • cDNA library was prepared from each RNA by the improved method (WO 01/04286) of oligo capping [M. Maruyama and S. Sugano, Gene, 138: 171-174 (1994)].
  • the single-stranded cDNA was converted to a double-stranded cDNA by PCR (polymerase chain reaction) using 5′ (SEQ ID NO: 3281) and 3′ (SEQ ID NO: 3282) PCR primers, and then digested with SfiI. Then, a fraction of cDNA fragments, typically 2-kb or longer (3-kb or longer in some cases), was unidirectionally cloned into a DraIII-digested pME18SFL3 vector ( FIG. 1 ) (GenBank AB009864, Expression vector); the cDNA library was thus prepared.
  • the cDNA library with the high fullness ratio (the fullness ratio of 5′-end, which was calculated for each cDNA library by using the protein coding region found in known mRNA species as an index, was 90% in average) prepared by the improved oligo-capping method was constructed by using a eukaryotic expression vector pME18SFL3.
  • the vector contains SR ⁇ promoter and SV40 small t intron in the upstream of the cloning site, and SV40 polyA added signal sequence site in the downstream.
  • the cloning site of pME18SFL3 has asymmetrical DraIII sites, and the ends of cDNA fragments contain SfiI sites complementary to the DraIII sites, the cloned cDNA fragments can be inserted into the downstream of the SR ⁇ promoter unidirectionally. Therefore, clones containing full-length cDNA can be expressed transiently by introducing the obtained plasmid directly into COS cells, etc. Thus, the clones can be analyzed very easily in terms of the proteins that are the gene products of the clones, or in terms of the biological activities of the proteins.
  • the nucleotide sequences of cDNA 5′-ends (3′-ends as well in some cases) were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual.
  • a database was constructed based on the obtained data.
  • the 5′-end completeness of about 770,000 clones derived from the human cDNA libraries prepared by the improved oligo-capping method was determined by the following method.
  • the clones whose 5′-end sequences were consistent with those of known human mRNA in the public database were judged to be “full-length” if they had a longer 5′-end sequence than that of the known human mRNA; or even though the 5′-end sequence was shorter, if it contained the translation initiation codon it was judged to have the “full-length” sequence. Clones which did not contain the translation initiation codon were judged to be “not-full-length”.
  • the fullness ratio ((the number of full-length clones)/(the number of full-length and not-full-length clones)) at the 5′-end of the cDNA clones was determined by comparing with known human mRNA. As a result, the fullness ratio of the 5′-ends was 90%. The result indicates that the fullness ratio at the 5′-end sequence was extremely high in the human cDNA clones obtained by the oligo-capping method.
  • the 5′-end nucleotide sequences of the cDNAs were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (Dye Terminator Cycle Sequencing FS Ready Reaction Kit, dRhodamine Terminator Cycle Sequencing FS Ready Reaction Kit or BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual.
  • a database was constructed using the data obtained.
  • the data with the annotation of “complete cds” in the GenBank and UniGene were searched by BLAST homology search. When identical to certain human mRNA sequences, such cDNA clones were excluded. Then, clustering was carried out. When the identity was 90% or higher, and the length of consensus sequence was 50 base pairs or longer, the cDNA clones were assumed to belong to an identical cluster, and thus clustered. cDNA clones longer in the 5′ direction were selected from the members belonging to a cluster; if required, the 3′-end sequences of the selected clones were determined by the same analysis method as used to determine the 5′-end sequences.
  • the data of the end sequences obtained were analyzed, and then the clones forming a sequence contig at 5′- and 3′-ends were excluded. Further, as mentioned above, the data was analyzed again by BLAST homology search; when identical to certain human mRNA sequences (including sequences patented and applied for), the cDNA clones were excluded. Thus, the cDNAs clones to be analyzed for their nucleotide sequence were obtained.
  • the full-length nucleotide sequences of the selected clones were determined.
  • the nucleotide sequence determination was mainly performed by primer walking method comprising the dideoxy terminator method using custom-made synthetic DNA primers. Namely, the nucleotide sequences of the DNAs were determined in a sequencer from PE Biosystems, after sequencing reaction was carried out with a DNA sequencing reagent from the same supplier using the custom-made synthetic DNA primers according to the manual. A part of the clones were analyzed with a DNA sequencer from Licor.
  • nucleotide sequences of a part of the clones were determined by the shotgun method where the plasmids containing the cDNAs were digested at random were used, instead of the use of custom-made primers, by the same method in the DNA sequencer.
  • the full-length nucleotide sequences were finally determined by completely assembling the partial nucleotide sequences obtained by the above method.
  • GenBank, SwissProt, UniGene, and nr were searched by BLAST.
  • the clones exhibiting higher homology, which were convenient to predict their functions based on the nucleotide sequences and deduced amino acid sequences, were selected based on the BLAST search hit data whose P value or E value was 10 ⁇ 4 or lower and for which the length of consensus sequence ⁇ homology 30 or higher in the amino acid database search. Further, from them, representative clones were selected, which are shown as Homology Search Result Data in the last part herein. Accordingly, the data shown herein are merely the representative data, and the molecule exhibiting homology to each clone is not limited thereto. Further, with respect to a part of clones, the BLAST search hit data that did not meet the criteria as described above are not shown herein.
  • amino acid sequence in which the signal sequence at the amino terminus or transmembrane domain had been predicted to be present by PSORT or SOSUI were assumed to be a secretory or membrane protein.
  • the protein function can be predicted based on the hit data, for example, by referring to the function categories on the PROSITE (http://www.expasy.ch/cgi-bin/prosite-list.pl).
  • the functional domain search can also be carried out on the PROSITE.
  • the clones whose deduced amino acid sequences were detected to have the signal sequences by PSORT are as follows.
  • the clones whose deduced amino acid sequences were detected to have the transmembrane domains by SOSUI are as follows. Numerals indicate the numbers of transmembrane domains detected in the deduced amino acid sequences. Of the search result, the clone name and the number of transmembrane domains are demarcated by a double slash mark (//).
  • the Names of clones whose deduced amino acid sequences were detected to have functional domains with Pfam, and the name of hit functional domains are as follows.
  • the search result is indicated as “clone name//functional domain name”.
  • the clone has multiple hit functional domains, they are listed and demarcated by a double slash mark (//).
  • the clone has multiple hits of an identical functional domain, each is listed without abridgment.
  • 3NB6920009120//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Frataxin-like domain
  • 3NB6920015570//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Z
  • ADRGL10000650//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2
  • BGGI120005330 //IMP dehydrogenase/GMP reductase N terminus//CBS domain//CBS domain//Dihydroorotate dehydrogenase//Histidine biosynthesis protein//FMN-dependent dehydrogenase//Conserved region in glutamate synthase//IMP dehydrogenase/GMP reductase C terminus
  • BGGI120017140//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)///Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • BNGH420005320//SCAN domain//KRAB box//Zinc finger C2H2 type//GATA zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type
  • BRACE10000930//Zinc finger C3HC4 type (RING finger)//TRAF-type zinc finger//TRAF-type zinc finger//MATH domain
  • BRACE20020910//Zinc finger C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//E7 protein, Early protein//B-box zinc finger.
  • BRACE20071740//KRAB box//Zinc finger C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • BRACE20074010 //EF hand//EF hand//Mitochondrial carrier proteins//Mitochondrial carrier proteins//Mitochondrial carrier proteins//Mitochondrial carrier proteins
  • BRAWH20004760//Zinc finger C2H2 type//Zinc finger
  • C2H2 type C2H2 type
  • BRAWH20006330//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • BRAWH20006860 //Eukaryotic protein kinase domain//Protein kinase C terminal domain
  • BRAWH20012030 //Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C3HC4 type (RING finger)//PHD-finger
  • BRAWH20089560 //Poly-adenylate binding protein, unique domain.//Magnesium chelatase, subunit ChII//Uncharacterized protein family UPF0034//KE2 family protein//Formin Homology 2 Domain
  • CTONG20025580//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FCBBF10005980//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger
  • FCBBF20009510//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FCBBF50002610//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type///Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H
  • FEBRA20003970//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)///Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type
  • FEBRA20003990//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2
  • FEBRA20004540//Zinc finger C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)///Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C
  • FEBRA20009720//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger
  • FEBRA20017150//Zinc finger C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//Insulin-like growth factor binding proteins//B-box zinc finger.//CONSTANS family zinc finger//B-box zinc finger.//Putative zinc finger in N-recognin//Fibronectin type III domain//SPRY domain
  • FEBRA20050140//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2
  • FEBRA20057880//PDZ domain Also known as DHR or GLGF.
  • FEBRA20064760//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//GATA zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type///Transcription factor S-II (TFIIS)///Zinc finger, C2H2 type//Zinc finger, C2
  • FEBRA20067360//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Z
  • FEBRA20069420//KRAB box//Zinc finger C2H2 type//Ribosomal protein L37e//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//
  • HCASM20003070//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • HLUNG20000680//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • HLUNG20001420//REV protein anti-repression trans-activator protein
  • Bacteriorhodopsin //Photosystem II reaction centre
  • HSYRA10001370//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H
  • HSYRA20016310//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type
  • IMR3210002420//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//
  • KIDNE20000510//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
  • KIDNE20040840 //Eukaryotic protein kinase domain//Phosphoribulokinase//Myosin head (motor domain)//Myosin head (motor domain)
  • KIDNE20059080 //Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats
  • KIDNE20060140//WD domain G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • KIDNE20078110//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type
  • NB9N410000470//WD domain G-beta repeat//WD domain
  • G-beta repeat//WD domain G-beta repeat//WD domain
  • G-beta repeat//WD domain G-beta repeat//WD domain
  • G-beta repeat//WD domain G-beta repeat//WD domain
  • NHNPC20002120//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
  • NT2NE20002590//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type
  • NT2NE20006580//Zinc finger C3HC4 type (RING finger)//ICE-like protease (caspase) p10 domain//SPRY domain
  • NT2NE20008090//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
  • NT2NE20034080 //EGF-like domain//Laminin EGF-like (Domains III and V)
  • NT2RI10000270//Zinc finger C-x8-C-x5-C-x3-H type (and similar).
  • NT2RI20004210//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20010830//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)///Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H
  • NT2RI20025410//Zinc finger C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zn-finger in ubiquitin-hydrolases and other proteins//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20033440//PDZ domain Also known as DHR or GLGF.
  • NT2RI20036950 //Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Insulin/IGF/Relaxin family//Ribosomal RNA adenine dimethylases//SAM domain (Sterile alpha motif)//TFIIE alpha subunit//Zinc finger, C3HC4 type (RING finger)
  • NT2RI20060710//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20067350//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20071330//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)///Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H
  • NT2RI20071480//WD domain G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • NT2RI20074390//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C
  • NT2RI20078840 //Homeobox domain//Bacterial regulatory proteins
  • crp family //Site-specific recombinases//Bacterial regulatory proteins
  • luxR family NT2RI20078840//Homeobox domain//Bacterial regulatory proteins
  • crp family //Site-specific recombinases//Bacterial regulatory proteins
  • luxR family NT2RI20078840//Homeobox domain//Bacterial regulatory proteins
  • crp family//Site-specific recombinases //Bacterial regulatory proteins
  • luxR family luxR family
  • NT2RI20078910//WD domain G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • NT2RI20080500 //Immunoglobul in domain//Immunoglobul in domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
  • NT2RI20085980 //Bacterial regulatory proteins, crp family//CUB domain//F5/8 type C domain
  • NT2RI20090650//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP60001000//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
  • NT2RP60001270//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70018560//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
  • NT2RP70023760//WD domain G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//TBC domain
  • NT2RP70032030//KRAB box//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//GATA zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C
  • NT2RP70033040 //Rhodanese-like domain//Integrase Zinc binding domain//Integrase Zinc binding domain//DnaJ central domain (4 repeats)
  • NT2RP70042040//PHD-finger//FYVE zinc finger//Zinc finger C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70042330 //TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
  • NT2RP70046870//Macrophage migration inhibitory factor (MIF)//WD domain G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//Arenavirus glycoprotein//WD domain, G-beta repeat

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Abstract

Novel full-length cDNAs are provided. 1639 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.

Description

    FIELD OF THE INVENTION
  • The present invention relates to polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and new uses of these.
    • BACKGROUND OF THE INVENTION
  • Currently, the sequencing projects, the determination and analysis of the genomic DNA of various living organisms have been in progress all over the world. The whole genomic sequences of more than 40 species of prokaryotes, a lower eukaryote, yeast, a multicellular eukaryote, C. elegans, and a higher plants, arabidopsis, etc. are already determined. For human genome, presumably having 3 billion base pairs, the analysis was advanced under global cooperative organization, and a draft sequence was disclosed in 2001. Moreover, all the structures are to be clear and to be disclosed in 2002-2003. The aim of the determination of genomic sequence is to reveal the functions of all genes and their regulation and to understand living organisms as a network of interactions between genes, proteins, cells or individuals through deducing the information in a genome, which is a blueprint of the highly complicated living organisms. To understand living organisms by utilizing the genomic information from various species is not only important as an academic subject, but also socially significant from the viewpoint of industrial application.
  • However, determination of genomic sequences itself cannot identify the functions of all genes. For example, as for yeast, only the function of approximately half of the 6000 genes, which is predicted based on the genomic sequence, was able to be deduced. On the other hand, the human genome has been estimated to contain about 30,000 genes. Further, 100,000 or more types of mRNAs are said to exist when variants produced by alternative splicing are taken into consideration. Therefore, it is desirable to establish “a high throughput analysis system of the gene functions” which allows us to identify rapidly and efficiently the functions of vast amounts of the genes obtained by the genomic sequencing.
  • Many genes in the eukaryotic genome are split by introns into multiple exons. Thus, it is difficult to predict correctly the structure of encoded protein solely based on genomic information. In contrast, cDNA, which is produced from mRNA that lacks introns, encodes a protein as a single continuous amino acid sequence and allows us to identify the primary structure of the protein easily. In human cDNA research, to date, more than three million ESTs (Expression Sequence Tags) are publicly available, and the ESTs presumably cover not less than 80% of all human genes.
  • The information of ESTs is utilized for analyzing the structure of human genome, or for predicting the exon-regions of genomic sequences or their expression profile. However, many human ESTs have been derived from proximal regions to the 3′-end of cDNA, and information around the 5′-end of mRNA is extremely little. Among human cDNAs, the number of the corresponding mRNAs whose encoding full-length protein sequences are deduced is approximately 13,000.
  • It is possible to identify the transcription start site of mRNA on the genomic sequence based on the 5′-end sequence of a full-length cDNA, and to analyze factors involved in the stability of mRNA that is contained in the cDNA, or in its regulation of expression at the translation stage. Also, since a full-length cDNA contains atg codon, the translation start site, in the 5′-region, it can be translated into a protein in a correct frame. Therefore, it is possible to produce a large amount of the protein encoded by the cDNA or to analyze biological activity of the expressed protein by utilizing an appropriate expression system. Thus, analysis of a full-length cDNA provides valuable information which complements the information from genome sequencing. Also, full-length cDNA clones that can be expressed are extremely valuable in empirical analysis of gene function and in industrial application.
  • Therefore, if a novel human full-length cDNA is isolated, it can be used for developing medicines for diseases in which the gene is involved. The protein encoded by the gene can be used as a drug by itself. Thus, it has great significance to obtain a full-length cDNA encoding a novel human protein.
  • In particular, human secretory proteins or membrane proteins would be useful by itself as a medicine like tissue plasminogen activator (TPA), or as a target of medicines like membrane receptors. In addition, genes for signal transduction-related proteins (protein kinases, etc.), glycoprotein-related proteins, transcription-related proteins, etc. are genes whose relationships to human diseases have been elucidated. Moreover, genes for disease-related proteins form a gene group rich in genes whose relationships to human diseases have been elucidated.
  • Therefore, it has great significance to isolate novel full-length cDNA clones of human, only few of which has been isolated. Especially, isolation of a novel cDNA clone encoding a secretory protein or membrane protein is desired since the protein itself would be useful as a medicine, and also the clones potentially include a gene involved in diseases. In addition, genes encoding proteins that are involved in signal transduction, glycoprotein, transcription, or diseases are expected to be useful as target molecules for therapy, or as medicines themselves. These genes form a gene group predicted to be strongly involved in diseases. Thus, identification of the full-length cDNA clones encoding those proteins has great significance.
    • SUMMARY OF THE INVENTION
  • An objective of the present invention is to provide polynucleotides encoding novel polypeptides, polypeptides encoded by the polynucleotides, and novel usages of these.
  • The inventors have developed a method for efficiently cloning, from a cDNA library having very high fullness-ratio, a human full-length cDNA that is predicted to be a full-length cDNA clone, where the cDNA library is synthesized by an improved method (WO 01/04286) of the oligo-capping method (K. Maruyama and S. Sugano, Gene, 138: 171-174 (1994); Y. Suzuki et al., Gene, 200: 149-156 (1997)). Then, the nucleotide sequences of cDNA clones whose fullness ratio is high, obtained by this method, were determined mainly from their 5′-ends, and, if required, from 3′-ends.
  • Further, representative clones, which were estimated to be novel and full-length, among the clones obtained, were analyzed for their full-length nucleotide sequences. The determined full-length nucleotide sequences were analyzed by BLAST homology search of the databases shown below. Because the homology search of the present invention is carried out based on the information of full-length cDNAs including the entire coding regions, homology to every part of a polypeptide can be analyzed. Thus, in the present invention, the reliability of homology search has been greatly improved.
  • [1] SwissProt (http://www.ebi.ac.uk/ebi_docsSwissProt_db/swisshome.html),
  • [2] GenBank (http://www.ncbi.nlm.nih.gov/web/GenBank),
  • [3] UniGene (Human) (http://www.ncbi.nlm.nih.gov/UniGene), and
  • [4] nr (a protein database, which has been constructed by combining data of coding sequences (CDS) in nucleotide sequences deposited in GenBank, and data of SwissProt, PDB (http://www.rcsb.org/pdb/index.html), PIR (http://pir.georgetown.edu/pirwww/pirhome.shtml), and PRF (http://www.prf.or.jp/en/); overlapping sequences have been removed.)
  • Further, the gene expression profiles of cDNA clones whose full-length nucleotide sequence had been determined were studied by analyzing the large-scale cDNA database constructed based on the 5′-end nucleotide sequences of cDNAs obtained. In addition to the analysis for the expression profile by computer, the profiles of gene expression in living cells were also determined by PCR. The present inventors revealed the usefulness of the genes of the present invention based on these analysis results.
  • In the present invention, gene functions were revealed by the analysis of expression profiles in silico based on the information of full-length nucleotide sequences. The expression profiles used in the expression frequency analysis were studied based on the database containing sufficient amount of fragment sequence data. The expression frequency analysis was carried out by referring, for these expression profiles, to the full-length nucleotide sequences of many cDNA clones obtained in the present invention. Thus, a highly reliable analysis can be achieved by referring to the full-length nucleotide sequences of a wide variety of genes for the sufficiently large population for analysis (expression profiles). Namely, the results of expression frequency analysis using the full-length sequences of the present invention more precisely reflect the gene expression frequency in tissues and cells from which a certain cDNA library was derived. In other words, the information of full-length cDNA nucleotide sequence of the present invention made it possible to achieve the highly reliable expression frequency analysis.
  • The full-length cDNA clones of this invention were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the high fullness ratio by oligo-capping, and [2] assembling 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction). However, the uses of primers designed based on the 5′- and 3′-end sequences of polynucleotides provided by the present invention enable readily obtaining full-length cDNAs without such a special technique. The primer, which is designed to be used for obtaining cDNAs capable of being expressed, is not limited to the 5′- and 3′-end sequences of polynucleotide.
  • Specifically, the present invention relates to a polynucleotide selected from the group consisting of the following (a) to (g):
  • (a) a polynucleotide comprising a protein-coding region of the nucleotide sequence of any one of SEQ ID NOs shown in Table 1;
  • (b) a polynucleotide encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1;
  • (c) a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs shown in Table 1, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted, and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
  • (d) a polynucleotide hybridizing under stringent conditions to a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NOs shown in Table 1, wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide encoded by the selected nucleotide sequence;
  • (e) a polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
  • (f) a polynucleotide comprising a nucleotide sequence having at least 70% identity to the nucleotide sequence of (a); and
  • (g) a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of (a).
  • The present invention also relates to a polypeptide encoded by the above-mentioned polynucleotide or a partial peptide thereof, an antibody binding to the polypeptide or the peptide, and a method for immunologically assaying the polypeptide or the peptide, which comprises the steps of contacting the polypeptide or the peptide with the antibody, and observing the binding between the two.
  • Furthermore, the present invention features a vector comprising the above-mentioned polynucleotide, a transformant carrying the polynucleotide or the vector, a transformant carrying the polynucleotide or the vector in an expressible manner, and a method for producing the polypeptide or the peptide, which comprises the steps of culturing the transformant and recovering an expression product.
  • Another feature of the present invention is an oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1639 or to a complementary strand thereof. This oligonucleotide can be used as a primer for synthesizing the above-mentioned polynucleotide or used as a probe for detecting the polynucleotide. The present invention includes an antisense polynucleotide against the polynucleotide or a part thereof, and a method for detecting the polynucleotide, which comprises the following steps of:
  • a) incubating a target polynucleotide with the oligonucleotide under hybridizable conditions, and
  • b) detecting hybridization of the target polynucleotide with the oligonucleotide.
  • Still another feature of the present invention is a database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 1639 and/or on at least one of the amino acid sequences of SEQ ID NOs: 1640 to 3278.
  • Herein, “polynucleotide” is defined as a molecule, such as DNA and RNA, in which multiple nucleotides are polymerized. There are no limitations on the number of the polymerized nucleotides. In case that the polymer contains relatively low number of nucleotides, it is also described as an “oligonucleotide”, which is included in the “polynucleotide” of the present invention. The polynucleotide or the oligonucleotide of the present invention can be a natural or chemically synthesized product. Alternatively, it can be synthesized using a template polynucleotide by an enzymatic reaction such as PCR. Furthermore, the polynucleotide of the present invention may be modified chemically. Moreover, not only a single-strand polynucleotide but also a double-strand polynucleotide is included in the present invention. In this specification, especially in claims, when the polynucleotide is described merely as “polynucleotide”, it means not only a single-strand polynucleotide but also a double-strand polynucleotide. When it means double-strand polynucleotide, the nucleotide sequence of only one chain is indicated. However, based on the nucleotide sequence of a sense chain, the nucleotide sequence of the complementary strand thereof is essentially determined.
  • As used herein, an “isolated polynucleotide” is a polynucleotide the structure of which is not identical to that of any naturally occurring polynucleotide or to that of any fragment of a naturally occurring genomic polynucleotide spanning more than three separate genes. The term therefore includes, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule in the genome of the organism in which it naturally occurs; (b) a polynucleotide incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion polypeptide. Specifically excluded from this definition are polynucleotides of DNA molecules present in mixtures of different (i) DNA molecules, (ii) transfected cells, or (iii) cell clones; e.g., as these occur in a DNA library such as a cDNA or genomic DNA library.
  • The term “substantially pure” as used herein in reference to a given protein or polypeptide means that the protein or polypeptide is substantially free from other biological macromolecules. For example, the substantially pure protein or polypeptide is at least 75%, 80%, 85%, 95%, or 99% pure by dry weight. Purity can be measured by any appropriate standard method known in the art, for example, by column chromatography, polyacrylamide gel electrophoresis, or HPLC analysis.
  • All the cDNAs provided by the present invention are full-length cDNAs. The “full-length cDNA” herein means that the cDNA contains the ATG codon, which is the start point of translation therein. The untranslated regions upstream and downstream of the protein-coding region, both of which are naturally contained in natural mRNAs, are not indispensable. It is preferable that the full-length cDNAs of the present invention contain the stop codon.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows the restriction map of the vector pME18SFL3.
    • DETAILED DESCRIPTION OF THE INVENTION
  • All the clones (1639 clones) of the present invention are novel and encode the full-length polypeptides. Further, all the clones are cDNAs with the high fullness ratio, which were obtained by oligo-capping method, and also clones which are not identical to any of known human mRNAs (namely, novel clones) selected by searching, for the 5′-end sequences, mRNA sequences with the annotation of “complete cds” in the GenBank and UniGene databases by using the BLAST homology search [S. F. Altschul, W. Gish, W. Miller, E. W. Myers & D. J. Lipman, J. Mol. Biol., 215: 403-410 (1990); W. Gish & D. J. States, Nature Genet., 3: 266-272 (1993)]; they are also clones that were assumed to have higher fullness ratio among the members in the cluster formed by assembling. Most of the clones assessed to have high fullness ratio in the cluster had the nucleotide sequences longer in the 5′-end direction.
  • All the full-length cDNAs of the present invention can be synthesized by a method such as PCR (Current protocols in Molecular Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons Section 6.1-6.4) using primer sets designed based on the 5′-end and 3′-end sequences or using primer sets of primers designed based on the 5′-end sequences and a primer of oligo dT sequence corresponding to poly A sequence. Table 1 contains the clone names of full-length cDNA of 1639 clones of the present invention, SEQ ID NOs of the full-length nucleotide sequences, CDS portions deduced from the full-length nucleotide sequences, and SEQ ID NOs of the translated amino acids. The positions of CDS are shown according to the rule of “DDBJ/EMBL/GenBank Feature Table Definition” (http://www.ncbi.nlm.nih.gov/collab/FT/index.html). The start position number corresponds to the first letter of “ATG” that is the nucleotide triplet encoding methionine; the termination position number corresponds to the third letter of the stop codon. These are indicated being flanked with the mark “ . . . ”. However, with respect to the clones having no stop codon, the termination position is indicated by the mark “>” according to the above rule.
    TABLE 1
    SEQ ID NO. SEQ ID NO.
    Clone of nucleotide Position of amino acid
    name sequence of CDS sequence
    3NB6910000180 1 505 . . . 1434 1640
    3NB6910000850 2 132 . . . 836 1641
    3NB6910001160 3 85 . . . 702 1642
    3NB6910001290 4 194 . . . 706 1643
    3NB6910001730 5 166 . . . >1755 1644
    3NB6920000290 6 991 . . . 1335 1645
    3NB6920002810 7 8 . . . 1375 1646
    3NB6920003300 8 128 . . . 901 1647
    3NB6920005450 9 21 . . . 809 1648
    3NB6920009120 10 247 . . . 1983 1649
    3NB6920010020 11 59 . . . 913 1650
    3NB6920010220 12 108 . . . 1289 1651
    3NB6920013490 13 402 . . . 1214 1652
    3NB6920014330 14 674 . . . 1516 1653
    3NB6920014710 15 369 . . . >1990 1654
    3NB6920015110 16 306 . . . 1163 1655
    3NB6920015280 17 162 . . . 1847 1656
    3NB6920015570 18 407 . . . 1903 1657
    3NB6920016370 19 25 . . . 348 1658
    3NB6920017190 20 151 . . . 1068 1659
    ADRGL10000020 21 7 . . . 1773 1660
    ADRGL10000180 22 1742 . . . 2110 1661
    ADRGL10000650 23 425 . . . 1072 1662
    ADRGL10001600 24 10 . . . 1407 1663
    ADRGL10001650 25 107 . . . 1387 1664
    ADRGL10001820 26 2165 . . . 2467 1665
    ADRGL20000740 27 114 . . . 1349 1666
    ADRGL20003230 28 118 . . . 516 1667
    ADRGL20004280 29 169 . . . 477 1668
    ASTR010000180 30 158 . . . 2716 1669
    ASTR020000950 31 110 . . . 1315 1670
    ASTR020004170 32 1121 . . . 1732 1671
    ASTR020004800 33 1177 . . . 1539 1672
    BGGI110002850 34 1119 . . . 1460 1673
    BGGI120001610 35 454 . . . 1185 1674
    BGGI120005330 36 79 . . . 1548 1675
    BGGI120005440 37 453 . . . 1661 1676
    BGGI120006840 38 140 . . . 1303 1677
    BGGI120006930 39 38 . . . 1627 1678
    BGGI120010970 40 264 . . . 2078 1679
    BGGI120017140 41 140 . . . 1009 1680
    BNGH410000030 42 780 . . . 1967 1681
    BNGH410000130 43 1087 . . . 1539 1682
    BNGH410000170 44 1466 . . . 1801 1683
    BNGH410000290 45 51 . . . 1661 1684
    BNGH410000330 46 2453 . . . 2782 1685
    BNGH410000340 47 539 . . . 1477 1686
    BNGH410000390 48 134 . . . 1135 1687
    BNGH410000800 49 232 . . . 549 1688
    BNGH410001040 50 146 . . . 1651 1689
    BNGH410001180 51 166 . . . >2624 1690
    BNGH410001370 52 61 . . . 1740 1691
    BNGH410001530 53 1368 . . . 1760 1692
    BNGH410001770 54 82 . . . 1773 1693
    BNGH410001900 55 113 . . . >2458 1694
    BNGH410001980 56 97 . . . 1476 1695
    BNGH420004740 57 1171 . . . 1473 1696
    BNGH420005320 58 354 . . . 1937 1697
    BRACE10000200 59 959 . . . 1267 1698
    BRACE10000420 60 214 . . . 1332 1699
    BRACE10000700 61 181 . . . 900 1700
    BRACE10000730 62 168 . . . 698 1701
    BRACE10000930 63 45 . . . 1388 1702
    BRACE10001150 64 76 . . . 624 1703
    BRACE10001590 65 225 . . . 767 1704
    BRACE10001660 66 777 . . . 1325 1705
    BRACE10001690 67 557 . . . 889 1706
    BRACE10001870 68 85 . . . 1704 1707
    BRACE20000770 69 162 . . . 605 1708
    BRACE20001000 70 1122 . . . 1430 1709
    BRACE20001410 71 229 . . . 975 1710
    BRACE20002800 72 35 . . . 1663 1711
    BRACE20003320 73 471 . . . 2063 1712
    BRACE20004210 74 1562 . . . 2716 1713
    BRACE20005050 75 711 . . . 1013 1714
    BRACE20005250 76 617 . . . 1144 1715
    BRACE20005450 77 184 . . . 498 1716
    BRACE20005650 78 272 . . . 841 1717
    BRACE20005770 79 514 . . . 816 1718
    BRACE20006980 80 85 . . . 1446 1719
    BRACE20007180 81 1263 . . . 1679 1720
    BRACE20008850 82 596 . . . >1809 1721
    BRACE20009880 83 1761 . . . 2069 1722
    BRACE20010650 84 1257 . . . 1922 1723
    BRACE20010700 85 1680 . . . >1989 1724
    BRACE20011170 86 87 . . . 410 1725
    BRACE20011430 87 1550 . . . 2041 1726
    BRACE20011880 88 742 . . . 1104 1727
    BRACE20013400 89 1495 . . . 1890 1728
    BRACE20013520 90 677 . . . 1048 1729
    BRACE20013740 91 1694 . . . 2317 1730
    BRACE20013750 92 821 . . . 1192 1731
    BRACE20014230 93 1523 . . . 1978 1732
    BRACE20014530 94 1747 . . . 2205 1733
    BRACE20014550 95 921 . . . 1838 1734
    BRACE20014770 96 351 . . . 1286 1735
    BRACE20014920 97 1306 . . . 1638 1736
    BRACE20015080 98 39 . . . 545 1737
    BRACE20015430 99 235 . . . 579 1738
    BRACE20016730 100 445 . . . 828 1739
    BRACE20016920 101 96 . . . 569 1740
    BRACE20017370 102 1612 . . . 2082 1741
    BRACE20018550 103 152 . . . 2008 1742
    BRACE20018590 104 902 . . . 1408 1743
    BRACE20018650 105 1143 . . . 1529 1744
    BRACE20018980 106 2178 . . . 2558 1745
    BRACE20019440 107 225 . . . 1205 1746
    BRACE20020500 108 605 . . . 1372 1747
    BRACE20020910 109 283 . . . 1176 1748
    BRACE20021510 110 1003 . . . 1653 1749
    BRACE20021760 111 393 . . . 1148 1750
    BRACE20022020 112 717 . . . 1727 1751
    BRACE20022270 113 3 . . . 353 1752
    BRACE20024090 114 165 . . . 845 1753
    BRACE20024310 115 2292 . . . 2618 1754
    BRACE20024680 116 65 . . . 1129 1755
    BRACE20024780 117 297 . . . 1154 1756
    BRACE20024950 118 49 . . . 369 1757
    BRACE20025900 119 636 . . . 941 1758
    BRACE20026350 120 106 . . . 753 1759
    BRACE20026850 121 113 . . . 1063 1760
    BRACE20027360 122 1147 . . . 1680 1761
    BRACE20027520 123 613 . . . 1215 1762
    BRACE20027550 124 168 . . . 578 1763
    BRACE20027720 125 169 . . . 777 1764
    BRACE20027920 126 105 . . . 1496 1765
    BRACE20027960 127 1731 . . . 2132 1766
    BRACE20028120 128 408 . . . 917 1767
    BRACE20028600 129 784 . . . 1593 1768
    BRACE20028610 130 774 . . . 1196 1769
    BRACE20028960 131 63 . . . 1472 1770
    BRACE20030780 132 236 . . . 637 1771
    BRACE20031100 133 214 . . . 2565 1772
    BRACE20032850 134 698 . . . 1327 1773
    BRACE20033190 135 202 . . . 531 1774
    BRACE20033980 136 811 . . . 1215 1775
    BRACE20034310 137 526 . . . 1461 1776
    BRACE20034490 138 1316 . . . 1699 1777
    BRACE20035160 139 492 . . . 896 1778
    BRACE20035270 140 572 . . . 1099 1779
    BRACE20035390 141 891 . . . 1211 1780
    BRACE20035940 142 80 . . . 601 1781
    BRACE20071380 143 190 . . . 1335 1782
    BRACE20071530 144 62 . . . 604 1783
    BRACE20071740 145 118 . . . 1800 1784
    BRACE20071970 146 1584 . . . 1895 1785
    BRACE20072010 147 422 . . . 1114 1786
    BRACE20072320 148 266 . . . 583 1787
    BRACE20072810 149 858 . . . 1193 1788
    BRACE20074010 150 92 . . . 1246 1789
    BRACE20074470 151 742 . . . 2109 1790
    BRACE20075020 152 2248 . . . 2553 1791
    BRACE20075270 153 1740 . . . 2285 1792
    BRACE20075380 154 1455 . . . 1889 1793
    BRACE20075630 155 996 . . . 1445 1794
    BRACE20076210 156 850 . . . 1509 1795
    BRACE20076410 157 78 . . . 1040 1796
    BRACE20076460 158 1368 . . . 1709 1797
    BRACE20076630 159 634 . . . 996 1798
    BRACE20076850 160 598 . . . 984 1799
    BRACE20077080 161 119 . . . 853 1800
    BRACE20077270 162 95 . . . 445 1801
    BRACE20077610 163 239 . . . 553 1802
    BRACE20077640 164 595 . . . 900 1803
    BRACE20077670 165 317 . . . 649 1804
    BRACE20077680 166 2013 . . . 2390 1805
    BRACE20077840 167 18 . . . 524 1806
    BRACE20077980 168 855 . . . 1604 1807
    BRACE20078680 169 1144 . . . >1753 1808
    BRACE20078820 170 2 . . . 580 1809
    BRACE20079020 171 1178 . . . 1681 1810
    BRACE20079530 172 8 . . . 331 1811
    BRACE20080970 173 1025 . . . 1348 1812
    BRACE20081140 174 14 . . . 463 1813
    BRACE20083800 175 71 . . . 1201 1814
    BRACE20083850 176 183 . . . 1046 1815
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    TESTI20040000 1507 291 . . . 881 3146
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    TESTI20041110 1509 143 . . . 502 3148
    TESTI20041220 1510 33 . . . 1703 3149
    TESTI20042070 1511 95 . . . 1903 3150
    TESTI20042290 1512 647 . . . 1711 3151
    TESTI20042430 1513 1227 . . . 1535 3152
    TESTI20042870 1514 1697 . . . 2263 3153
    TESTI20042950 1515 187 . . . 1887 3154
    TESTI20047120 1516 112 . . . 1002 3155
    TESTI20049290 1517 402 . . . 1226 3156
    TESTI20049820 1518 157 . . . 1875 3157
    TESTI20049940 1519 50 . . . 550 3158
    TESTI20051550 1520 79 . . . 501 3159
    TESTI20052680 1521 60 . . . 1247 3160
    TESTI20053960 1522 402 . . . 2522 3161
    TESTI20054080 1523 108 . . . 929 3162
    TESTI20054920 1524 137 . . . 568 3163
    TESTI20055840 1525 210 . . . 1214 3164
    TESTI20056900 1526 124 . . . 1788 3165
    TESTI20057310 1527 287 . . . >1853 3166
    TESTI20057420 1528 164 . . . 1636 3167
    TESTI20058600 1529 430 . . . 1167 3168
    TESTI20062380 1530 719 . . . 1567 3169
    TESTI20062550 1531 511 . . . 837 3170
    TESTI20064250 1532 537 . . . 1436 3171
    TESTI20064830 1533 373 . . . 1614 3172
    TESTI20065720 1534 222 . . . 644 3173
    TESTI20067740 1535 382 . . . 1239 3174
    TESTI20068660 1536 87 . . . 1337 3175
    TESTI20068720 1537 378 . . . 1331 3176
    TESTI20069780 1538 310 . . . 639 3177
    TESTI20069790 1539 887 . . . 1189 3178
    TESTI20071830 1540 352 . . . 1176 3179
    TESTI20073580 1541 3 . . . 1394 3180
    TESTI20074020 1542 1097 . . . 1426 3181
    TESTI20074640 1543 204 . . . >1824 3182
    TESTI20074660 1544 124 . . . 1683 3183
    TESTI20074800 1545 81 . . . 2000 3184
    TESTI20076130 1546 122 . . . >2107 3185
    TESTI20077490 1547 852 . . . 1598 3186
    TESTI20077500 1548 391 . . . 1722 3187
    TESTI20078140 1549 897 . . . 1400 3188
    TESTI20078640 1550 287 . . . 802 3189
    TESTI20078670 1551 318 . . . 1952 3190
    TESTI20078720 1552 92 . . . 1309 3191
    TESTI20079510 1553 824 . . . 3025 3192
    TESTI20080200 1554 153 . . . 2429 3193
    TESTI20080330 1555 72 . . . 497 3194
    TESTI20081390 1556 118 . . . 1839 3195
    TESTI20081440 1557 147 . . . 545 3196
    TESTI20082340 1558 931 . . . 1419 3197
    TESTI20082400 1559 409 . . . 834 3198
    TESTI20083430 1560 157 . . . 2979 3199
    TESTI20083870 1561 31 . . . 552 3200
    TESTI20084400 1562 1749 . . . 2078 3201
    TESTI20086570 1563 246 . . . 1289 3202
    TESTI20087740 1564 14 . . . 1900 3203
    TESTI20088470 1565 362 . . . 757 3204
    TESTI20136910 1566 1667 . . . 2026 3205
    TESTI20138320 1567 98 . . . 1060 3206
    TESTI20140360 1568 831 . . . 1349 3207
    TESTI20177400 1569 70 . . . 1584 3208
    TESTI30000020 1570 97 . . . 1914 3209
    THYMU10000020 1571 286 . . . 1131 3210
    THYMU10000320 1572 1299 . . . 1691 3211
    THYMU10000830 1573 1169 . . . 1936 3212
    THYMU10001050 1574 632 . . . 934 3213
    THYMU10001760 1575 1 . . . 492 3214
    THYMU10002910 1576 1598 . . . 2026 3215
    THYMU10003290 1577 22 . . . 534 3216
    THYMU10003590 1578 743 . . . 2005 3217
    THYMU10003660 1579 1749 . . . 2084 3218
    THYMU10003820 1580 1242 . . . 1601 3219
    THYMU10004590 1581 594 . . . 1142 3220
    THYMU10004730 1582 421 . . . 735 3221
    THYMU10004910 1583 301 . . . 1119 3222
    THYMU10005270 1584 1706 . . . >2057 3223
    THYMU10005580 1585 896 . . . 1819 3224
    THYMU20001400 1586 42 . . . 410 3225
    THYMU20002360 1587 2 . . . 385 3226
    THYMU20003170 1588 703 . . . 1041 3227
    THYMU20003690 1589 328 . . . 1782 3228
    TRACH10000180 1590 63 . . . 1205 3229
    TRACH10000300 1591 384 . . . 902 3230
    TRACH10000570 1592 722 . . . 1039 3231
    TRACH10000630 1593 431 . . . 1372 3232
    TRACH10000740 1594 80 . . . 1672 3233
    TRACH10001000 1595 181 . . . 660 3234
    TRACH10001060 1596 744 . . . 1121 3235
    TRACH10001250 1597 21 . . . 1610 3236
    TRACH10001400 1598 266 . . . 622 3237
    TRACH20000150 1599 1303 . . . 1755 3238
    TRACH20000790 1600 47 . . . 385 3239
    TRACH20001850 1601 19 . . . 750 3240
    TRACH20001960 1602 144 . . . 974 3241
    TRACH20002350 1603 1123 . . . 1437 3242
    TRACH20002370 1604 197 . . . 1471 3243
    TRACH20002500 1605 120 . . . 1682 3244
    TRACH20002890 1606 895 . . . 2022 3245
    TRACH20003930 1607 1403 . . . >2562 3246
    TRACH20004110 1608 150 . . . 1844 3247
    TRACH20004200 1609 80 . . . >2895 3248
    TRACH20004610 1610 498 . . . 2084 3249
    TRACH20004720 1611 435 . . . 1940 3250
    TRACH20004960 1612 115 . . . 1842 3251
    TRACH20004970 1613 1083 . . . 1517 3252
    TRACH20006650 1614 208 . . . 1866 3253
    TRACH20006750 1615 232 . . . 1200 3254
    TRACH20007670 1616 1147 . . . 1452 3255
    TRACH20007800 1617 492 . . . 1937 3256
    TRACH20008940 1618 701 . . . 1957 3257
    TRACH20008980 1619 350 . . . 661 3258
    TRACH20009260 1620 75 . . . 770 3259
    TRACH20009440 1621 879 . . . 1235 3260
    TRACH20011920 1622 530 . . . >2034 3261
    TRACH20012890 1623 143 . . . 715 3262
    TRACH20013950 1624 1697 . . . 2602 3263
    TRACH20014000 1625 1626 . . . 1949 3264
    TRACH20015920 1626 569 . . . 877 3265
    TRACH20016070 1627 484 . . . 1176 3266
    UMVEN10001220 1628 698 . . . 1339 3267
    UMVEN20001330 1629 164 . . . 2242 3268
    UTERU10000770 1630 2074 . . . 2418 3269
    UTERU10000960 1631 952 . . . 1593 3270
    UTERU10001600 1632 527 . . . 1747 3271
    UTERU10001920 1633 112 . . . 474 3272
    UTERU20000470 1634 1691 . . . >2197 3273
    UTERU20003380 1635 130 . . . 816 3274
    UTERU20003930 1636 514 . . . 1101 3275
    UTERU20004850 1637 385 . . . 732 3276
    UTERU20005410 1638 432 . . . 800 3277
    UTERU20005690 1639 217 . . . 1899 3278
  • Namely, primers used to synthesize polynucleotides can be designed based on the nucleotide sequences of polynucleotides of the present invention shown in SEQ ID NOs in the above Table 1. When one intends to synthesize full-length cDNAs, an oligo dT primer can be used as the 3′-end primer. The length of the primers is usually 15-100 bp, and favorably between 15-35 bp. In case of LA PCR, which is described below, the primer length of 25-35 bp may provide a good result.
  • A method to design a primer that enables a specific amplification based on the aimed nucleotide sequence is known to those skilled in the art (Current Protocols in Molecular Biology, Ausubel et al. edit, (1987) John Wiley & Sons, Section 6.1-6.4). In designing a primer based on the 5′-end sequence, the primer is designed so as that, in principle, the amplification products will include the translation start site. Accordingly, for example, when the 5′-end primer is designed based on the nucleotide sequence of 5′ untranslated region (5′UTR), any part of the 5′-end, which ensures the specificity to the cDNA of interest, can be selected as the primer.
  • When synthesizing a full-length cDNA, the target nucleotide sequence to be amplified can extend to several thousand bp in some cDNA. However, it is possible to amplify such a long nucleotides by using such as LA PCR (Long and Accurate PCR). It is advantageous to use LA PCR when synthesizing long DNA. In LA PCR, in which a special DNA polymerase having 3′->5′ exonuclease activity is used, misincorporated nucleotides can be removed. Accordingly, accurate synthesis of the complementary strand can be achieved even with a long nucleotide sequence. By using LA PCR, it is reported that amplification of a nucleotide with 20 kb longer can be achieved under desirable conditions (Takeshi Hayashi (1996) Jikken-Igaku Bessatsu, “Advanced Technologies in PCR” Youdo-sha).
  • A template DNA for synthesizing the full-length cDNA of the present invention can be obtained by using cDNA libraries that are prepared by various methods. The full-length cDNA clones of the present invention are clones with high probability of completeness in length, which were obtained by the method comprising the steps of [1] preparing libraries containing cDNAs with the very high fullness ratio by oligo-capping, and [2] assembling the 5′-end sequences and selecting one with the highest probability of completeness in length in the cluster formed (there are many clones longer in the 5′-end direction).
  • However, the uses of primers designed based on the full-length nucleotide sequences provided by the present invention enable easily obtaining full-length cDNAs without such a special technique.
  • The problem with the cDNA libraries prepared by the known methods or commercially available is that mRNA contained in the libraries has very low fullness ratio. Thus, it is difficult to screen full-length cDNA clone directly from the library using ordinary cloning methods. The present invention has revealed a nucleotide sequence of novel full-length cDNA. If a full-length nucleotide sequence is provided, it is possible to synthesize a target full-length cDNA by using enzymatic reactions such as PCR. In particular, a full-length-enriched cDNA library, synthesized by methods such as oligo-capping, is desirable to synthesize a full-length cDNA with more reliability.
  • The 5′-end sequence of the full-length cDNA clones of the invention can be used to isolate the regulatory element of transcription including the promoter on the genome. A rough draft of the human genome (analysis of human genomic sequence with lower accuracy), which covers 90% of the genome, has been reported (Nature, Vol. 409, 814-823, 2001), and by the year 2003, analysis of the entire human genomic sequence is going to be finished. However, it is hard to analyze with software the transcription start sites on the human genome, in which long introns exist. By contrast, it is easy to specify the transcription start site on the genomic sequence using the nucleotide sequence which includes the 5′-end of the full-length cDNA clone of the present invention, and thus it is easy to obtain the genomic region involved in transcription regulation, which includes the promoter that is contained in the upstream of the transcription start site.
  • The polypeptide encoded by the full-length cDNA of the invention can be prepared as a recombinant polypeptide or as a natural polypeptide. For example, the recombinant polypeptide can be prepared by inserting the polynucleotide encoding the polypeptide of the invention into a vector, introducing the vector into an appropriate host cell and purifying the polypeptide expressed within the transformed host cell, as described below. In contrast, the natural polypeptide can be prepared, for example, by utilizing an affinity column to which an antibody against the polypeptide of the invention (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 16.1-16.19) is attached. The antibody used for affinity purification may be either a polyclonal antibody, or a monoclonal antibody. Alternatively, in vitro translation (See, for example, “On the fidelity of mRNA translation in the nuclease-treated rabbit reticulocyte lysate system.” Dasso M. C., and Jackson R. J. (1989) Nucleic Acids Res. 17: 3129-3144) may be used for preparing the polypeptide of the invention.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared based on the activities, which were clarified in the above-mentioned manner, of the polypeptides of the present invention. Using the biological activity possessed by the polypeptide of the invention as an index, it is possible to verify whether or not a particular polypeptide is functionally equivalent to the polypeptide of the invention by examining whether or not the polypeptide has said activity.
  • Polypeptides functionally equivalent to the polypeptides of the present invention can be prepared by those skilled in the art, for example, by using a method for introducing mutations into an amino acid sequence of a polypeptide (for example, site-directed mutagenesis (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 8.1-8.5) Besides, such polypeptides can be generated by spontaneous mutations. The present invention also includes a polypeptide comprising the amino acid sequence shown in Table 1 in which one or more amino acids are substituted, deleted, inserted, and/or added, as long as the polypeptides have the equivalent functions to those of the polypeptides identified in the present Examples described later.
  • There are no limitations on the number and sites of amino acid mutations, as long as the polypeptides maintain the functions thereof. The number of mutations typically corresponds to 30% or less, or 20% or less, or 10% or less, preferably 5% or less, or 3% or less of the total amino acids, more preferably 2% or less or 1% or less of the total amino acids. Alternatively, herein, substitution of one or more amino acids includes substitution of several amino acids. As used herein, the term “several amino acids” means, for example, 5 amino acids, preferably 4 or 3 amino acids, more preferably 2 amino acids, and further preferably 1 amino acid.
  • From the viewpoint of maintaining the polypeptide function, it is preferable that a substituted amino acid has a similar property to that of the original amino acid. For example, Ala, Val, Leu, Ile, Pro, Met, Phe and Trp are assumed to have similar properties to one another because they are all classified into a group of non-polar amino acids. Similarly, substitution can be performed among non-charged amino acid such as Gly, Ser, Thr, Cys, Tyr, Asn, and Gln, acidic amino acids such as Asp and Glu, and basic amino acids such as Lys, Arg, and His.
  • In addition, polypeptides functionally equivalent to the polypeptides of the present invention can be isolated by using techniques of hybridization or gene amplification known to those skilled in the art. Specifically, using the hybridization technique (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.3-6.4)), those skilled in the art can usually isolate a polynucleotide highly homologous to the polynucleotide encoding the polypeptide identified in the present Example based on the identified nucleotide sequence (Table 1) or a portion thereof and obtain the functionally equivalent polypeptide from the isolated polynucleotide. The present invention include polypeptides encoded by the polynucleotides hybridizing with the polynucleotides encoding the polypeptides identified in the present Example, as long as the polypeptides are functionally equivalent to the polypeptides identified in the present Example. Organisms from which the functionally equivalent polypeptides are isolated are illustrated by vertebrates such as human, mouse, rat, rabbit, pig and bovine, but are not limited to these animals.
  • Washing conditions of hybridization for the isolation of polynucleotides encoding the functionally equivalent polypeptides are usually “1×SSC, 0.1% SDS, 37° C.”; more stringent conditions are “0.5×SSC, 0.1% SDS, 42° C.”; and still more stringent conditions are “0.1×SSC, 0.1% SDS, 65° C.”. Alternatively, the following conditions can be given as hybridization conditions of the present invention. Namely, conditions in which the hybridization is done at “6×SSC, 40% Formamide, 25° C.”, and the washing at “1×SSC, 55° C.” can be given. More preferable conditions are those in which the hybridization is done at “6×SSC, 40% Formamide, 37° C.”, and the washing at “0.2×SSC, 55° C.”. Even more preferable are those in which the hybridization is done at “6×SSC, 50% Formamide, 37° C.”, and the washing at “0.1×SSC, 62° C.”. The more stringent the conditions of hybridization are, the more frequently the polynucleotides highly homologous to the probe sequence are isolated. Therefore, it is preferable to conduct hybridization under stringent conditions. Examples of stringent conditions in the present invention are, washing conditions of “0.5×SSC, 0.1% SDS, 42° C.”, or alternatively, hybridization conditions of “6×SSC, 40% Formamide, 37° C.”, and the washing at “0.2×SSC, 55° C.”.
  • One skilled in the art can suitably select various conditions, such as dilution ratios of SSC, formamide concentrations, and temperatures to accomplish a similar stringency.
  • However, the above-mentioned combinations of SSC, SDS and temperature conditions are indicated just as examples. Those skilled in the art can select the hybridization conditions with similar stringency to those mentioned above by properly combining the above-mentioned or other factors (for example, probe concentration, probe length and duration of hybridization reaction) that determines the stringency of hybridization.
  • The amino acid sequences of polypeptides isolated by using the hybridization techniques usually have high identity to those of the polypeptides of the present invention, which are shown in Table 1. The present invention encompasses a polynucleotide comprising a nucleotide sequence that has a high identity to the nucleotide sequence of claim 1 (a). Furthermore, the present invention encompasses a peptide, or polypeptide comprising an amino acid sequence that has a high identity to the amino acid sequence encoded by the polynucleotide of claim 1 (b). The term “high identity” indicates sequence identity of at least 40% or more; preferably 60% or more; and more preferably 70% or more. Alternatively, more preferable is identity of 90% or more, or 93% or more, or 95% or more, furthermore, 97% or more, or 99% or more. The identity can be determined by using the BLAST search algorithm.
  • As used herein, “percent identity” of amino acid sequences or nucleic acids is determined using the algorithm BLAST of Karlin and Altschul (Proc. Natl. Acad. Sci. USA 90:5873-5877, 1993). Such an algorithm is incorporated into the BLASTN and BLASTX programs of Altschul et al. (J. Mol. Biol. 215:403-410, 1990). BLAST nucleotide searches are performed with the BLASTN program, for example, score=100, wordlength=12. BLAST protein searches are performed with the BLASTX program, for example, score=50, wordlength=3. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs are used. See http://www.ncbi.nlm.nih.gov.
  • With the gene amplification technique (PCR) (Current Protocols in Molecular Biology, edit, Ausubel et al., (1987) John Wiley & Sons, Section 6.1-6.4)) using primers designed based on the nucleotide sequence (Table 1) or a portion thereof identified in the present Example, it is possible to isolate a polynucleotide fragment highly homologous to the polynucleotide sequence or a portion thereof and to obtain functionally equivalent polypeptide to a particular polypeptide identified in the present Example based on the isolated polynucleotide fragment.
  • The present invention also provides a polynucleotide containing at least 15 nucleotides complementary to a polynucleotide comprising a nucleotide sequence of SEQ ID NOs shown in Table 1 or the complementary strand thereof. Herein, the term “complementary strand” is defined as one strand of a double strand DNA composed of A:T and G:C base pair to the other strand. Also, “complementary” is defined as not only those completely matching within a continuous region of at least 15 nucleotides, but also having a identity of at least 70%, favorably 80% or higher, more favorably 90% or higher, and most favorably 95% or higher within that region. The identity may be determined using the algorithm described herein.
  • Such a polynucleotide includes probes and primers used for the detection and amplification of a polynucleotide encoding the inventive polypeptide. When used as a primer, the polynucleotide usually comprises 15 to 100 bp, and preferably of 15 to 35 bp. When used as a probe, the polynucleotide comprises the whole or a part of the sequence of a polynucleotide of the invention, and comprises at least 15 bp. When used as primers, such polynucleotides are complementary at the 3′-end, and restriction enzyme recognition sequences or tags can be added to the 5′-end.
  • Furthermore, polynucleotides of the present invention include an antisense polynucleotide for suppressing the expression of a polypeptide of the invention, which comprises an amino acid sequence of SEQ ID NOs shown in Table 1. To exert an antisense effect, an antisense polynucleotide has at least 15 bp or more, for example 50 bp or more, preferably 100 bp or more, and more preferably 500 bp or more, and usually has 3000 bp or less, and preferably 2000 bp or less. Antisense polynucleotides can be used in the gene therapy of diseases caused by abnormalities of the polypeptides of the invention (abnormal function or abnormal expression). An antisense polynucleotide can be prepared, for example, by the phosphorothioate method (“Physicochemical properties of phosphorothioate oligodeoxynucleotides.” Stein (1988) Nucleic Acids Res. 16: 3209-3221) based on the sequence information of polynucleotide encoding a polypeptide of the invention (for example, the nucleotide sequences of SEQ ID NO: 1 to 1639).
  • The polynucleotides or antisense polynucleotides of the present invention can be used in, for example, gene therapy. As target diseases, for example, cancers or various inflammatory diseases may be preferable. These molecules can be used for gene therapy, for example, by administrating them to patients by the in vivo or ex vivo method using virus vectors such as retrovirus vectors, adenovirus vectors, and adeno-related virus vectors, or non-virus vectors such as liposomes.
  • The present invention also includes a partial peptide of the polypeptides of the invention. The partial peptide comprises a polypeptide generated as a result that a signal peptide has been removed from a secretory protein. If the polypeptide of the present invention has an activity as a receptor or a ligand, the partial peptide may function as a competitive inhibitor of the polypeptide and may bind to the receptor (or ligand). In addition, the present invention includes an antigen peptide for raising antibodies. For the peptides to be specific for the polypeptide of the invention, the peptides comprise at least 7 amino acids, preferably 8 amino acids or more, more preferably 9 amino acids or more, and even more preferably 10 amino acids or more. The peptide can be used for preparing antibodies against the polypeptide of the invention, or competitive inhibitors of them, and also screening for a receptor that binds to the polypeptide of the invention. The partial peptides of the invention can be produced, for example, by genetic engineering methods, known methods for synthesizing peptides, or digesting the polypeptide of the invention with an appropriate peptidase.
  • The present invention also relates to a vector into which a polynucleotide of the invention is inserted. The vector of the invention is not limited as long as it contains the inserted polynucleotide stably. For example, if E. coli is used as a host, vectors such as pBluescript vector (Stratagene) are preferable as a cloning vector. To produce the polypeptide of the invention, expression vectors are especially useful. Any expression vector can be used as long as it is capable of expressing the polypeptide in vitro, in E. coli, in cultured cells, or in vivo. For example, pBEST vector (Promega) is preferable for in vitro expression, pET vector (Invitrogen) for E. coli, pME18S-FL3 vector (GenBank Accession No. AB009864) for cultured cells, and pME18S vector (Mol. Cell. Biol. (1988) 8: 466-472) for in vivo expression. To insert the polynucleotide of the invention, ligation utilizing restriction sites can be performed according to the standard method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • Recently, the technique of GATEWAY™ system (Invitrogen), which is an expression vector construction system for polypeptide expression, has been developed (Experimental Medicine, Vol. 18, No. 19 (December), p2716-2717, 2000). This system includes two types of site-specific recombinases (BP CLONASE™ and LR CLONASE™) derived from lambda phage and uses BP CLONASE™-specific recombination sites for an Entry Vector and LR CLONASE™-specific recombination sites for a Destination Vector, which may comprise a tag useful for polypeptide purification. With this system, an expression vector can be obtained by using homologous recombination.
  • First, a polynucleotide fragment of interest is inserted into the entry vector using the first recombination. Then, the secondary recombination is allowed to take place between the entry vector, where the polynucleotide fragment of interest has been inserted, and the destination vector. Thus, the expression vector can be prepared rapidly and highly efficiently. With the above-mentioned typical method using restriction enzyme and ligase reactions, the step of expression vector construction and expression of polypeptide of interest takes about 7 to 10 days. However, with the GATEWAY™ system, the polypeptide of interest can be expressed and prepared in only 3 to 4 days. Thus, the system ensures a high-throughput functional analysis for expressed polypeptides (http://biotech.nikkeibp.co.jp/netlink/lto/gateway/).
  • The present invention also relates to a transformant carrying the vector of the invention. Any cell can be used as a host into which the vector of the invention is inserted, and various kinds of host cells can be used depending on the purposes. For strong expression of the polypeptide in eukaryotic cells, COS cells or CHO cells can be used, for example.
  • Introduction of the vector into host cells can be performed, for example, by calcium phosphate precipitation method, electroporation method (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 9.1-9.9), lipofectamine method (GIBCO-BRL), or microinjection method, etc.
  • Further, a polynucleotide containing at least 15 nucleotides comprising a nucleotide sequence of any one of the polynucleotides comprising the nucleotide sequences of SEQ ID NOs shown in Table 1 or the complementary strand thereof can be used not only as a primer for synthesizing full-length cDNAs but also for testing and diagnosing the abnormalities of the polypeptide encoded by the full-length cDNA of the present invention. For example, by utilizing polymerase chain reaction (genomic DNA-PCR, or RT-PCR) using the polynucleotide of the invention as a primer, polynucleotide encoding the polypeptide of the invention can be amplified. It is also possible to obtain the regulatory region of expression in the 5′-upstream by using PCR or hybridization since the transcription start site within the genomic sequence can be easily specified based on the 5′-end sequence of the full-length cDNA. The obtained genomic region can be used for detection and/or diagnosis of the abnormality of the sequence by RFLP analysis, SSCP, or sequencing. Especially, in the case where expression of the mRNA of the present invention varies according to a specific disease, analysis of the amount of expression of the mRNA using the polynucleotide of the present invention as a probe or a primer enables detection and diagnosis of the disease.
  • The present invention also relates to antibodies that bind to the polypeptide of the invention. There are no limitations in the form of the antibodies of the invention. They include polyclonal antibodies, monoclonal antibodies, or their portions that can bind to an antigen. They also include antibodies of all classes. Furthermore, special antibodies such as humanized antibodies and chimeric antibodies are also included.
  • The polyclonal antibody of the invention can be obtained according to the standard method by synthesizing an oligopeptide corresponding to the amino acid sequence and immunizing rabbits with the peptide (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.12-11.13). The monoclonal antibody of the invention can be obtained according to the standard method by purifying the polypeptide expressed in E. coli, immunizing mice with the polypeptide, and producing a hybridoma cell by fusing the spleen cells and myeloma cells (Current Protocols in Molecular Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section 11.4-11.11).
  • The antibody binding to the polypeptide of the present invention can be used for purification of the polypeptide of the invention, and also for detection and/or diagnosis of the abnormalities of the expression and structure of the polypeptide. Specifically, polypeptides can be extracted, for example, from tissues, blood, or cells, and the polypeptide of the invention is detected by Western blotting, immunoprecipitation, or ELISA, etc. for the above purpose.
  • Furthermore, the antibody binding to the polypeptide of the present invention can be utilized for treating the diseases that associates with the polypeptide of the invention. If the antibodies are used for treating patients, human antibodies, humanized antibodies, or chimeric antibodies are preferable in terms of their low antigenicity. The human antibodies can be prepared by immunizing a mouse whose immune system is replaced with that of human (e.g., see “Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice” Mendez, M. J. et al. (1997) Nat. Genet. 15: 146-156). The humanized antibodies can be prepared by recombination of the hypervariable region of a monoclonal antibody (Methods in Enzymology (1991) 203: 99-121).
  • The use of the amino acid sequences of the polypeptides encoded by the cDNAs of the present invention enables predicting that the polypeptides have the following functions. It can be predict, from the results of homology search of SwissProt, GenBank, UniGene, or nr, that these polypeptides have such functions. Specifically, for instance, as shown in Examples, searching for a known gene or polypeptide that is homologous to the partial sequence of the full-length cDNA of the invention (1639 clone) and referring the function of the gene and of the polypeptide encoded by the gene make it possible to predict the function of the polypeptide encoded by the cDNA of the invention. In this way, each of 892 clones out of the 1639 full-length cDNA clones of the invention was predicted to encode a polypeptide that was classified into the following categories.
  • Secretory and/or membrane protein (439 clones)
  • Glycoprotein-related protein (87 clones)
  • Signal transduction-related protein (46 clones)
  • Transcription-related protein (140 clones)
  • Disease-related protein (219 clones)
  • Enzyme and/or metabolism-related protein (168 clones)
  • Cell division- and/or cell proliferation-related protein (23 clones)
  • Cytoskeleton-related protein (60 clones)
  • Nuclear protein and/or RNA synthesis-related protein (59 clones)
  • Protein synthesis- and/or transport-related protein (24 clones)
  • Cellular defense-related protein (6 clones)
  • Development and/or differentiation-related protein (19 clones)
  • DNA- and/or RNA-binding protein (158 clones)
  • ATP- and/or GTP-binding protein (63 clones)
  • The functions of the polypeptides encoded by the cDNAs of the present invention can be predicted by assessing the presence of signal sequence, transmembrane region, nuclear translocation signal, glycosylation signal, phosphorylation site, and zinc finger motif, SH3 domain, etc. in the amino acid sequences. The programs, PSORT (Nakai K., and Kanehisa M. (1992) Genomics 14: 897-911), SOSUI (Hirokawa T. et al. (1998) Bioinformatics 14: 378-379) (Mitsui Knowledge Industry), and MEMSAT (Jones D. T., Taylor W. R., and Thornton J. M. (1994) Biochemistry 33: 3038-3049) can be used to predict the existence of the signal sequence or transmembrane region. Alternatively, a partial amino acid sequence of the polypeptide is fused with another polypeptide such as GFP, the fusion polypeptide is transfected into cultured cells, and the localization is analyzed to predict the function of the original polypeptide.
  • Based on the determined nucleotide sequences of the full-length cDNAs obtained in the present invention, it is possible to predict more detailed functions of the polypeptides encoded by the cDNA clones, for example, by searching the databases such as GenBank, Swiss-Prot, UniGene, and nr for homologies of the cDNAs; or by searching the amino acid sequences deduced from the full-length cDNAs for signal sequences by using software programs such as PSORT, for transmembrane regions by using software programs such as SOSUI or for motifs by using software programs such as Pfam (http://www.sanger.ac.uk/Software/Pfam/index.shtml) and PROSITE (http://www.expasy.ch/prosite/). As a matter of course, the functions are often predictable by using partial sequence information (preferably 300 nucleotides or more) instead of the full-length nucleotide sequences. However, the result of the prediction by using partial nucleotide sequence does not always agree with the result obtained by using full-length nucleotide sequence, and thus, it is needless to say that the prediction of function is preferably performed based on the full-length nucleotide sequences.
  • GenBank, Swiss-Prot, UniGene and nr databases were searched for homologies of the full-length nucleotide sequences of the 1639 clones (see Example 6). The amino acid sequences deduced from the full-length nucleotide sequences were searched for functional domains by PSORT, SOSUI and Pfam. Prediction of functions of polypeptides encoded by the clones and the categorization thereof were performed based on these results obtained. The categorization was carried out by the following method.
  • [1] Firstly, the cDNA clones were classified into the above-mentioned 14 functional categories based on the results of annotation-based categorization (using the keywords in the case of Swiss-Prot hit data; using Definition or Reference information in the case of GenBank, UniGene, or nr hit data), and the signal sequence search of the deduced ORFs by PSORT and the transmembrane region search by SOSUI.
  • [2] Secondly, clones which had been unassignable to the categories by the method of [1] were searched for functional domains and/or motifs by Pfam. Based on the results, the clones were additionally classified into the above-mentioned 14 types of categories when they had a functional domain and/or motif assignable to any one of the categories.
  • The following 439 clones presumably belong to secretory and/or membrane proteins.
  • 3NB6910000180, 3NB6910000850, 3NB6920000290, 3NB6920003300, 3NB6920005450, 3NB6920010020, ADRGL10000180, ADRGL10001600, ADRGL20003230, BGGI120010970, BNGH410000340, BNGH410001040, BNGH410001180, BNGH410001370, BNGH410001980, BRACE10000730, BRACE10001690, BRACE20002800, BRACE20007180, BRACE20010650, BRACE20011170, BRACE20011430, BRACE20013400, BRACE20013520, BRACE20014230, BRACE20014530, BRACE20014920, BRACE20015080, BRACE20018590, BRACE20022270, BRACE20024680, BRACE20026350, BRACE20026850, BRACE20030780, BRACE20031100, BRACE20034490, BRACE20071380, BRACE20071970, BRACE20072810, BRACE20074010, BRACE20074470, BRACE20075020, BRACE20075380, BRACE20076410, BRACE20076630, BRACE20076850, BRACE20077610, BRACE20077640, BRACE20077980, BRACE20078680, BRACE20079530, BRACE20084430, BRACE20086550, BRACE20089600, BRACE20091880, BRAWH10000010, BRAWH10000370, BRAWH10000940, BRAWH10001620, BRAWH10001800, BRAWH20001090, BRAWH20004430, BRAWH20006970, BRAWH20009840, BRAWH20011290, BRAWH20011410, BRAWH20011660, BRAWH20014380, BRAWH20014840, BRAWH20015030, BRAWH20036930, BRAWH20038320, BRAWH20040950, BRAWH20052250, BRAWH20059980, BRAWH20087060, BRAWH20092610, CD34C20000510, CTONG20013660, CTONG20015330, CTONG20028160, CTONG20037820, CTONG20047160, DFNES20003350, FCBBF10006180, FCBBF10006750, FCBBF20005910, FCBBF20007330, FCBBF20008150, FCBBF20009400, FCBBF20015380, FEBRA20003780, FEBRA20004040, FEBRA20004150, FEBRA20004520, FEBRA20004910, FEBRA20006560, FEBRA20006900, FEBRA20007330, FEBRA20008090, FEBRA20008800, FEBRA20010930, FEBRA20012270, FEBRA20012450, FEBRA20012940, FEBRA20013510, FEBRA20014870, FEBRA20014920, FEBRA20015840, FEBRA20020860, FEBRA20021910, FEBRA20025250, FEBRA20031550, FEBRA20037070, FEBRA20041100, FEBRA20041910, FEBRA20057780, FEBRA20063150, FEBRA20066670, FEBRA20067930, HCASM10000610, HCASM20002020, HEART20000990, HEART20004920, HHDPC20000950, HLUNG10000240, HLUNG10000370, HLUNG10001100, HLUNG20001160, HLUNG20001250, HLUNG20001420, HLUNG20001760, HLUNG20002550, HSYRA20003470, HSYRA20006290, HSYRA20008280, HSYRA20011030, HSYRA20013320, HSYRA20014200, HSYRA20015800, IMR3210000440, IMR3210001580, IMR3210002660, IMR3220007750, IMR3220008590, IMR3220009840, IMR3220014350, KIDNE10000080, KIDNE10001040, KIDNE10001430, KIDNE20000700, KIDNE20000850, KIDNE20001670, KIDNE20003150, KIDNE20003300, KIDNE20003490, KIDNE20004220, KIDNE20005170, KIDNE20005190, KIDNE20033050, KIDNE20033570, KIDNE20039410, KIDNE20042620, KIDNE20042950, KIDNE20044110, KIDNE20048280, KIDNE20049810, KIDNE20054000, KIDNE20054770, KIDNE20060530, KIDNE20060620, KIDNE20063530, KIDNE20063760, KIDNE20066520, KIDNE20067600, KIDNE20071860, KIDNE20073520, KIDNE20074220, KIDNE20075690, LIVER10000580, LIVER10000670, LIVER10001040, LIVER10001110, LIVER10001750, LIVER10005420, LIVER20004160, MAMGL10000320, MAMGL10001840, MESAN10000350, MESAN10001470, MESAN10001800, MESAN20001490, NB9N420000420, NHNPC20002060, NT2NE10000230, NT2NE10000830, NT2NE10001630, NT2NE20003270, NT2NE20003920, NT2NE20004550, NT2NE20004700, NT2NE20005500, NT2NE20012470, NT2NE20014350, NT2NE20016260, NT2NE20034080, NT2NE20047160, NT2NE20055170, NT2NE20057200, NT2RI20005970, NT2RI20009740, NT2RI20010100, NT2RI20014490, NT2RI20015400, NT2RI20015950, NT2RI20016570, NT2RI20018660, NT2RI20020220, NT2RI20021520, NT2RI20022430, NT2RI20022520, NT2RI20025300, NT2RI20030110, NT2RI20030510, NT2RI20031540, NT2RI20033010, NT2RI20033830, NT2RI20036780, NT2RI20042840, NT2RI20044420, NT2RI20049850, NT2RI20050870, NT2RI20051500, NT2RI20066820, NT2RI20068250, NT2RI20070480, NT2RI20070840, NT2RI20073030, NT2RI20074980, NT2RI20077540, NT2RI20078270, NT2RI20080500, NT2RI20081880, NT2RI20084810, NT2RI20085980, NT2RI20089420, NT2RI20092890, NT2RI20094060, NT2RP60000320, NT2RP60000390, NT2RP60001090, NT2RP70000690, NT2RP70002380, NT2RP70002590, NT2RP70003640, NT2RP70011660, NT2RP70015910, NT2RP70021510, NT2RP70023760, NT2RP70023790, NT2RP70026190, NT2RP70029820, NT2RP70040800, NT2RP70043730, NT2RP70047900, NT2RP70049250, NT2RP70055200, NT2RP70064080, NT2RP70071540, NT2RP70071770, NT2RP70073810, NT2RP70074220, NT2RP70075040, NT2RP70076170, NT2RP70079250, NT2RP70079750, NT2RP70081330, NT2RP70081370, NT2RP70083150, NT2RP70085500, NT2RP70090120, NT2RP70091490, NT2RP70091680, NT2RP70092360, NT2RP70093220, NT2RP70093730, NT2RP70094290, NT2RP70094810, NT2RP70094980, NT2RP70095070, NTONG10000980, NTONG10002140, NTONG10002570, NTONG20002650, NTONG20004920, NTONG20008000, NTONG20012220, OCBBF10000420, OCBBF20002310, OCBBF20009980, OCBBF20012100, PANCR10000210, PLACE50000670, PLACE50000680, PLACE50001050, PLACE50001130, PLACE60012810, PLACE60018860, PLACE60020160, PLACE60020840, PLACE60026990, PLACE60037050, PLACE60037450, PLACE60043960, PLACE60044540, PLACE60047380, PLACE60049930, PLACE60050290, PROST10002200, PROST10002720, PROST10005260, PROST10005360, PROST20000360, PROST20026820, PROST20029600, PROST20032320, PROST20033020, PROST20039220, PROST20044160, PROST20051430, PROST20054260, PROST20058800, PROST20059190, PROST20059430, PROST20069880, PROST20072370, PROST20073890, PUAEN10000570, PUAEN10003220, SALGL10001570, SKMUS20007740, SKNMC10000190, SKNMC10000290, SKNMC10002290, SKNMC10002510, SKNMC20011130, SKNMC20015030, SMINT10000160, SMINT10000420, SMINT10000570, SMINT10001180, SMINT20000180, SMINT20002770, SPLEN10000910, SPLEN20001340, SPLEN20002430, SPLEN20002700, SPLEN20003100, SPLEN20004960, STOMA10000520, STOMA10001170, STOMA20000320, STOMA20002570, SYNOV20001770, SYNOV20016480, TESTI10000420, TESTI10000960, TESTI10001270, TESTI10001380, TESTI20001770, TESTI20006000, TESTI20007620, TESTI20008830, TESTI20009090, TESTI20009700, TESTI20011340, TESTI20012370, TESTI20013520, TESTI20014200, TESTI20016210, TESTI20016710, TESTI20018520, TESTI20018620, TESTI20020020, TESTI20020810, TESTI20022510, TESTI20024230, TESTI20024650, TESTI20024670, TESTI20025800, TESTI20026320, TESTI20026980, TESTI20027000, TESTI20027070, TESTI20028660, TESTI20030370, TESTI20031930, TESTI20034190, TESTI20036490, TESTI20039980, TESTI20042870, TESTI20047120, TESTI20049940, TESTI20056900, TESTI20057420, TESTI20058600, TESTI20067740, TESTI20069780, TESTI20074800, TESTI20077490, TESTI20079510, TESTI20080200, TESTI20081440, TESTI20087740, TESTI20088470, TESTI20136910, THYMU10000830, THYMU10001760, THYMU10003290, THYMU10003820, THYMU10005580, TRACH10000630, TRACH10001000, TRACH10001400, TRACH20001850, TRACH20001960, TRACH20004200, TRACH20004960, TRACH20006650, TRACH20007670, TRACH20008980, TRACH20015920, UMVEN20001330, UTERU10000770, UTERU10000960, UTERU10001920, UTERU20000470, UTERU20003930, UTERU20004850
  • The following 87 clones presumably belong to glycoprotein-related proteins.
  • BNGH410000340, BNGH410001180, BRACE20014920, BRACE20015080, BRACE20018590, BRACE20024680, BRACE20026350, BRACE20031100, BRACE20074470, BRAWH10000370, BRAWH20001090, BRAWH20011660, BRAWH20014840, BRAWH20059980, CD34C20000510, CTONG20013660, CTONG20028160, CTONG20037820, FCBBF20007330, FEBRA20007330, FEBRA20008800, FEBRA20014920, FEBRA20015840, FEBRA20057780, HEART20005060, HLUNG10001100, HLUNG20002550, HSYRA20013320, IMR3210002660, IMR3220007750, IMR3220013320, KIDNE20044110, KIDNE20063760, KIDNE20067600, KIDNE20073520, LIVER20000370, MESAN10000350, NT2NE10000830, NT2NE10001850, NT2NE20003270, NT2NE20016260, NT2RI20018660, NT2RI20025300, NT2RI20036780, NT2RI20077540, NT2RI20080500, NT2RI20085980, NT2RI20089420, NT2RI20092890, NT2RP70000690, NT2RP70004770, NT2RP70055200, NT2RP70081370, NT2RP70083150, NT2RP70091490, NT2RP70092360, NT2RP70094980, NTONG10002140, OCBBF20002310, OCBBF20002770, PLACE50000680, PLACE50001130, PLACE60018860, PLACE60044540, PROST20018230, PROST20032320, PROST20073890, SALGL10001570, SKNMC20015030, SMINT10000160, SMINT20002770, SPLEN20001340, TESTI10001270, TESTI10001380, TESTI20001770, TESTI20024230, TESTI20027070, TESTI20036490, TESTI20039980, TESTI20056900, TESTI20057420, TESTI20079510, THYMU10001760, TRACH10000740, TRACH10001250, TRACH20004200, UTERU20000470
  • The following 46 clones presumably belong to signal transduction-related proteins.
  • ADRGL20000740, ASTRO10000180, BRACE20005770, BRACE20022020, BRACE20027360, BRACE20027920, BRAWH20006860, CTONG20005890, FEBRA20000350, HHDPC20000550, IMR3220003020, KIDNE20033730, KIDNE20040840, KIDNE20053360, KIDNE20062990, NT2RI20033440, NT2RI20058110, NT2RI20062100, NT2RI20073840, NT2RP70006240, NT2RP70043960, NT2RP70046870, NT2RP70061880, NT2RP70072520, NT2RP70081440, NT2RP70093700, NTONG10001820, PEBLM20004790, PLACE60026680, PROST20033400, PROST20043320, SKMUS10000220, SKMUS20016680, SPLEN20003570, TESTI20001540, TESTI20005910, TESTI20022560, TESTI20024980, TESTI20029120, TESTI20034980, TESTI20049820, TESTI20055840, THYMU10003590, THYMU20003690, TRACH20002500, TRACH20002890
  • The following 140 clones presumably belong to transcription-related proteins.
  • 3NB6920010220, 3NB6920015110, 3NB6920015570, ADRGL10000650, BGGI120006840, BGGI120006930, BGGI120017140, BNGH410000800, BNGH420005320, BRACE10000930, BRACE20014550, BRACE20018550, BRACE20020910, BRACE20024090, BRACE20071740, BRAWH10000020, BRAWH10001640, BRAWH10001680, BRAWH20006330, BRAWH20009010, CTONG20025580, CTONG20028200, FCBBF10005980, FCBBF20000940, FCBBF20009510, FCBBF50002610, FEBRA20003970, FEBRA20003990, FEBRA20004540, FEBRA20009720, FEBRA20011460, FEBRA20017150, FEBRA20050140, FEBRA20064760, FEBRA20067360, FEBRA20069420, FEBRA20072800, HLUNG10000760, HLUNG20000680, HSYRA10001370, HSYRA20016310, IMR3210002420, IMR3220007420, KIDNE20000510, KIDNE20039940, KIDNE20061490, KIDNE20078110, NESOP10000870, NHNPC10001240, NHNPC20002120, NT2NE20002590, NT2NE20008090, NT2RI20003410, NT2RI20004120, NT2RI20004210, NT2RI20010830, NT2RI20018460, NT2RI20025410, NT2RI20025850, NT2RI20060710, NT2RI20067350, NT2RI20071330, NT2RI20074390, NT2RI20078790, NT2RI20087140, NT2RI20090650, NT2RI20092150, NT2RP60001000, NT2RP60001270, NT2RP70002710, NT2RP70008120, NT2RP70018560, NT2RP70024500, NT2RP70032030, NT2RP70036290, NT2RP70042040, NT2RP70045410, NT2RP70046560, NT2RP70055130, NT2RP70061620, NT2RP70062960, NT2RP70064900, NT2RP70069860, NT2RP70075370, NT2RP70085570, NT2RP70087200, NT2RP70090190, NTONG20003340, NTONG20003630, NTONG20015500, OCBBF20011010, OCBBF20011240, OCBBF20015860, PEBLM20002480, PEBLM20002700, PEBLM20003080, PEBLM20003950, PLACE60002050, PLACE60005550, PLACE60021510, PLACE60030380, PROST20018230, PROST20031170, PROST20073170, PUAEN10001610, SALGL10000650, SKMUS10000640, SKMUS20014920, SKNMC20000650, SKNMC20002240, SKNMC20003560, SMINT10001000, SMINT20005450, SPLEN20000200, SPLEN20000720, SYNOV20010140, SYNOV20013740, SYNOV20014510, TESTI10000550, TESTI20001200, TESTI20007070, TESTI20010490, TESTI20015560, TESTI20018150, TESTI20018790, TESTI20021490, TESTI20026760, TESTI20027890, TESTI20030710, TESTI20034130, TESTI20042290, TESTI20053960, TESTI20074640, TESTI20074660, TESTI20078640, THYMU10004590, TRACH20000790, TRACH20002370, TRACH20009440, UTERU10001600
  • The following 219 clones presumably belong to disease-related proteins.
  • ADRGL10000020, ADRGL10001600, ADRGL20000740, ASTRO20004170, BGGI120006840, BGGI120010970, BGGI120017140, BNGH410001770, BNGH420005320, BRACE10001870, BRACE20006980, BRACE20007180, BRACE20014550, BRACE20018550, BRACE20018590, BRACE20027550, BRACE20027720, BRACE20076850, BRACE20086550, BRAWH10000020, BRAWH10001640, BRAWH20001770, BRAWH20005030, BRAWH20005220, BRAWH20006330, BRAWH20006860, BRAWH20009840, BRAWH20011660, CD34C20000510, CTONG20005890, CTONG20019110, CTONG20024180, CTONG20025580, CTONG20037820, CTONG20055530, FCBBF20000940, FCBBF20009510, FCBBF40002820, FEBRA20001050, FEBRA20003990, FEBRA20004150, FEBRA20004540, FEBRA20009720, FEBRA20010930, FEBRA20011460, FEBRA20050790, FEBRA20057880, FEBRA20064760, FEBRA20067930, FEBRA20070170, FEBRA20075510, FEBRA20075660, HCASM20002140, HEART20004480, HLUNG10001050, HLUNG20000680, HSYRA10001370, HSYRA20006400, HSYRA20013320, HSYRA20016310, IMR3210000440, IMR3220007910, KIDNE10001040, KIDNE20003150, KIDNE20033730, KIDNE20042950, KIDNE20044110, KIDNE20050420, KIDNE20059080, KIDNE20063760, KIDNE20078110, LIVER10002300, LIVER10004330, LIVER20000330, LIVER20000370, MAMGL10001780, MESAN10001800, MESAN20002910, MESAN20005010, NB9N410001350, NHNPC10000840, NHNPC20002120, NT2NE10000730, NT2NE20002990, NT2NE20003690, NT2NE20005170, NT2NE20005360, NT2NE20006580, NT2NE20008090, NT2NE20013720, NT2NE20016340, NT2NE20055170, NT2RI20004120, NT2RI20004210, NT2RI20010910, NT2RI20014500, NT2RI20020410, NT2RI20029580, NT2RI20031540, NT2RI20033440, NT2RI20041900, NT2RI20056470, NT2RI20057230, NT2RI20067030, NT2RI20070960, NT2RI20074980, NT2RI20077540, NT2RI20080500, NT2RI20083960, NT2RI20084810, NT2RI20092150, NT2RI20092890, NT2RP60000350, NT2RP60001000, NT2RP60001230, NT2RP70000690, NT2RP70004250, NT2RP70028750, NT2RP70029060, NT2RP70032030, NT2RP70036290, NT2RP70042600, NT2RP70046560, NT2RP70049250, NT2RP70055020, NT2RP70062960, NT2RP70063040, NT2RP70065270, NT2RP70069860, NT2RP70071770, NT2RP70073810, NT2RP70074220, NT2RP70075370, NT2RP70079250, NT2RP70081440, NT2RP70090120, NT2RP70090190, NT2RP70093220, NT2RP70094980, NTONG10002460, NTONG20003630, NTONG20015500, OCBBF10001180, OCBBF20008240, PEBLM10000340, PEBLM20002480, PEBLM20003080, PEBLM20003950, PLACE50000800, PLACE60002050, PLACE60003790, PLACE60014430, PROST10001670, PROST10005360, PROST20002730, PROST20032320, PROST20033400, PROST20062600, PROST20072890, PROST20073890, PROST20085160, SALGL10001570, SKMUS10000140, SKMUS10001180, SKMUS10001290, SKMUS20000740, SKMUS20003900, SKMUS20007240, SKMUS20016340, SKNMC10002510, SKNMC20000650, SKNMC20003220, SMINT10000420, SMINT10000570, SMINT10001000, SMINT10001030, SMINT20004000, SPLEN10001430, SPLEN20001970, STOMA20000880, STOMA20003960, SYNOV20013740, SYNOV20014510, SYNOV20016480, TESTI10001270, TESTI10001310, TESTI20001200, TESTI20001770, TESTI20002530, TESTI20006000, TESTI20006990, TESTI20007620, TESTI20008830, TESTI20011800, TESTI20012690, TESTI20015120, TESTI20018520, TESTI20018790, TESTI20021490, TESTI20025160, TESTI20027070, TESTI20027290, TESTI20029120, TESTI20033250, TESTI20049820, TESTI20053960, TESTI20068660, TESTI20071830, TESTI20074640, TESTI20079510, TESTI20086570, TESTI20140360, THYMU10000830, THYMU10001760, THYMU10003590, THYMU10004910, TRACH20002370, UTERU10000960, UTERU20000470
  • The following 168 clones presumably belong to the category of enzymes and/or metabolism-related proteins.
  • 3NB6920002810, ADRGL10001600, ADRGL10001650, BGGI120005330, BNGH410000340, BNGH410001770, BRACE10000420, BRACE20015080, BRACE20022020, BRACE20024680, BRACE20026850, BRACE20027360, BRACE20027720, BRACE20027920, BRACE20071380, BRACE20084430, BRAWH20001770, BRAWH20006510, BRAWH20006860, BRAWH20009840, BRAWH20011660, BRAWH20014180, BRAWH20014840, BRAWH20036890, BRAWH20059980, BRAWH20069890, BRAWH20089560, CTONG20013660, CTONG20019110, DFNES20002120, FCBBF20007330, FCBBF20015380, FEBRA20000350, FEBRA20001290, FEBRA20003110, FEBRA20024420, FEBRA20041100, FEBRA20045920, FEBRA20050790, FEBRA20052160, FEBRA20062700, FEBRA20063150, HEART20000350, HHDPC20000550, HHDPC20004550, HLUNG10001050, HLUNG20002550, HSYRA10001680, HSYRA20005100, HSYRA20015740, IMR3220008380, IMR3220009190, IMR3220012180, IMR3220013170, KIDNE20000410, KIDNE20003490, KIDNE20004220, KIDNE20005130, KIDNE20033050, KIDNE20040840, KIDNE20046810, KIDNE20056290, KIDNE20060530, KIDNE20063760, KIDNE20068800, KIDNE20073280, KIDNE20073520, KIDNE20078100, LIVER10000670, LIVER10002300, MAMGL10001780, MESAN20002910, MESAN20005010, NT2NE10000730, NT2NE10001850, NT2NE20002140, NT2NE20003270, NT2NE20003690, NT2NE20005860, NT2NE20013720, NT2NE20016340, NT2NE20016660, NT2RI10000480, NT2RI20010100, NT2RI20015400, NT2RI20020220, NT2RI20025300, NT2RI20033010, NT2RI20036780, NT2RI20037510, NT2RI20051500, NT2RI20068550, NT2RI20073840, NT2RI20074980, NT2RI20084810, NT2RI20087910, NT2RP70004770, NT2RP70006240, NT2RP70011660, NT2RP70026190, NT2RP70062960, NT2RP70072520, NT2RP70076100, NT2RP70081440, NT2RP70084060, NT2RP70085570, NT2RP70093700, NTONG10001820, OCBBF20008240, OCBBF20012100, OCBBF20014080, OCBBF20014940, PANCR10000210, PEBLM20004790, PLACE50001050, PLACE50001130, PLACE60003790, PLACE60012810, PLACE60018860, PLACE60044540, PROST20031170, PROST20032320, PROST20033400, PROST20051210, PROST20064500, SKMUS10001290, SKMUS10001770, SKMUS20000740, SKMUS20007240, SKMUS20008630, SKMUS20009330, SKMUS20011290, SKNSH10001740, SKNSH20003470, SMINT10000160, SPLEN20001340, STOMA10001860, STOMA20001210, STOMA20004820, SYNOV20016480, TESTI10000700, TESTI10001380, TESTI20001540, TESTI20005910, TESTI20012690, TESTI20018270, TESTI20022560, TESTI20027070, TESTI20029120, TESTI20034190, TESTI20034980, TESTI20040000, TESTI20042070, TESTI20042950, TESTI20047120, TESTI20049820, TESTI20138320, TESTI20140360, TESTI30000020, THYMU10000830, THYMU10004910, THYMU20003170, THYMU20003690, TRACH20000150, TRACH20004720, TRACH20004970, TRACH20009260, UTERU10000960
  • The following 23 clones presumably belong to the category of cell division- and/or cell proliferation-related proteins.
  • BGGI120001610, BRACE20027550, BRACE20076850, BRAWH20005030, BRAWH20005220, FEBRA20075660, HCASM20002140, HLUNG10000640, IMR3220009730, NT2NE20003840, NT2RI20006850, NT2RI20041900, NT2RI20058110, NTONG10002460, NTONG20008780, SKMUS20016340, SKNMC20003220, SPLEN10001430, TESTI10001680, TESTI20001840, TESTI20021050, TESTI20035120, TESTI20057310
  • The following 60 clones presumably belong to the category of cytoskeleton-related proteins.
  • ADRGL10000020, BRACE20006980, BRACE20008850, BRACE20027960, BRACE20074470, BRACE20076630, BRACE20078820, BRACE20093070, BRAWH20000480, BRAWH20066220, CTONG20019550, CTONG20028160, CTONG20055530, DFNES20002680, FCBBF20005910, FEBRA20007720, FEBRA20008810, FEBRA20034290, FEBRA20043290, FEBRA20072000, HEART20004480, HEART20005200, HLUNG10001100, HSYRA20006050, IMR3220007910, KIDNE20040840, KIDNE20052960, NT2RI20014090, NT2RI20032220, NT2RI20058510, NT2RI20090660, NT2RP70000690, NT2RP70004250, NT2RP70028750, NT2RP70042600, NT2RP70049250, NT2RP70074220, NTONG20009660, OCBBF20011760, OCBBF20015280, PEBLM10000680, PROST10001670, PROST20033380, TESTI10000420, TESTI10000510, TESTI20003560, TESTI20004350, TESTI20006000, TESTI20006990, TESTI20008490, TESTI20008830, TESTI20011410, TESTI20015110, TESTI20016610, TESTI20020570, TESTI20024230, TESTI20031090, TESTI20031170, TESTI20039140, TESTI20078720
  • The following 59 clones presumably belong to the category of nuclear proteins and/or RNA synthesis-related proteins.
  • 3NB6920002810, 3NB6920015280, BGGI120005440, BRACE10001150, BRACE20024780, BRACE20027550, BRAWH20005030, BRAWH20014180, BRAWH20069890, CTONG20024180, FEBRA20001290, FEBRA20075660, HEART20003090, HLUNG10000640, HSYRA10001680, HSYRA20005100, IMR3220008630, IMR3220012180, MAMGL10001780, NT2NE10001850, NT2NE20002140, NT2NE20003840, NT2NE20016660, NT2NE20054410, NT2RI20002820, NT2RI20006850, NT2RI20010910, NT2RI20025540, NT2RI20041900, NT2RI20053350, NT2RI20057230, NT2RI20060720, NT2RI20067030, NT2RI20068550, NT2RI20078840, NT2RI20087490, NT2RP70004770, NT2RP70013060, NT2RP70076430, NTONG20008780, PEBLM10000340, PLACE50000580, PLACE60003790, PROST20001760, PROST20062600, SKMUS10000220, SKMUS20016340, SKNMC20003220, SPLEN10001430, SPLEN20001970, TESTI10001680, TESTI20002530, TESTI20007840, TESTI20021050, TESTI20029120, TESTI20035120, TESTI20057310, TRACH20003930, TRACH20012890
  • The following 24 clones presumably belong to the category of protein synthesis- and/or protein transport-related proteins.
  • BRACE20078680, FEBRA20075510, IMR3220008380, KIDNE20005190, KIDNE20050420, MESAN20002910, NB9N410001350, NT2NE20005360, NT2RI20032050, NT2RI20032220, NT2RP70000760, NT2RP70076430, NT2RP70093940, OCBBF20008240, PLACE50000580, PROST20000530, SKMUS20000740, SKMUS20008630, TESTI20007840, TESTI20015120, TESTI20018690, TESTI20078720, THYMU10005580, UMVEN20001330
  • The following 6 clones presumably belong to the category of cellular defense-related proteins.
  • BRACE20014550, NT2RI20037510, NT2RI20053350, NT2RP70029060, NT2RP70062960, PLACE50001700
  • The following 19 clones presumably belong to the category of development and/or differentiation-related proteins.
  • BGGI120006930, CTONG20028200, FCBBF50002610, FEBRA20014920, FEBRA20017150, FEBRA20060920, MAMGL10001820, NESOP10000870, NHNPC10001240, NT2RI20078790, NT2RP70008120, NT2RP70018560, NT2RP70045410, OCBBF20002770, SALGL10000650, SMINT10001000, TESTI10000550, TESTI20026760, TESTI20078140
  • The following 158 clones presumably belong to the category of DNA- and/or RNA-binding proteins.
  • 3NB6920002810, 3NB6920010220, 3NB6920015110, 3NB6920015570, ADRGL10000650, BGGI120006840, BGGI120006930, BNGH410000800, BNGH420005320, BRACE20014550, BRACE20020910, BRACE20024090, BRACE20024780, BRACE20071740, BRAWH10001640, BRAWH10001680, BRAWH20000340, BRAWH20006330, BRAWH20009010, BRAWH20014180, BRAWH20069890, CTONG20025580, CTONG20028200, D3OST20001840, FCBBF10005980, FCBBF20009510, FCBBF50002610, FEBRA20003970, FEBRA20003990, FEBRA20004540, FEBRA20008560, FEBRA20009720, FEBRA20017150, FEBRA20017900, FEBRA20050140, FEBRA20064760, FEBRA20067360, FEBRA20069420, FEBRA20072800, HEART20003090, HLUNG10000760, HSYRA10001370, HSYRA20016310, IMR3210002420, IMR3220007420, IMR3220008630, KIDNE20000510, KIDNE20039940, KIDNE20061490, KIDNE20078110, NESOP10000870, NHNPC10000840, NHNPC10001240, NHNPC20002120, NT2NE20002590, NT2NE20003840, NT2NE20008090, NT2NE20016660, NT2NE20054410, NT2RI20003410, NT2RI20004210, NT2RI20006850, NT2RI20010830, NT2RI20010910, NT2RI20025410, NT2RI20025850, NT2RI20057230, NT2RI20060710, NT2RI20067350, NT2RI20071330, NT2RI20074390, NT2RI20078790, NT2RI20078840, NT2RI20087140, NT2RI20087490, NT2RI20090650, NT2RP60001000, NT2RP60001270, NT2RP70002710, NT2RP70008120, NT2RP70013060, NT2RP70018560, NT2RP70024500, NT2RP70032030, NT2RP70042040, NT2RP70045410, NT2RP70046560, NT2RP70055130, NT2RP70061620, NT2RP70062960, NT2RP70064900, NT2RP70069860, NT2RP70075370, NT2RP70081670, NT2RP70085570, NT2RP70087200, NT2RP70090190, NTONG20003340, NTONG20008780, NTONG20015500, OCBBF20011010, OCBBF20015860, PEBLM10000340, PEBLM20001120, PEBLM20002700, PEBLM20003080, PLACE60002050, PLACE60005550, PLACE60021510, PLACE60030380, PROST20001760, PROST20003250, PROST20018230, PROST20031170, PROST20062600, PROST20073170, SALGL10000650, SKMUS10000640, SKMUS20014920, SKMUS20016340, SKNMC20000650, SKNMC20002240, SKNMC20003220, SKNMC20003560, SMINT10001000, SMINT20005450, SPLEN10001430, SPLEN20000200, SPLEN20000720, SPLEN20001970, SYNOV20010140, SYNOV20013740, SYNOV20014510, TESTI10000550, TESTI20001200, TESTI20007070, TESTI20010490, TESTI20013450, TESTI20015560, TESTI20018150, TESTI20021050, TESTI20021490, TESTI20026760, TESTI20027890, TESTI20030710, TESTI20033270, TESTI20034130, TESTI20035120, TESTI20053960, TESTI20074640, TESTI20074660, TESTI20078640, THYMU10004590, TRACH20000790, TRACH20002370, TRACH20009440, TRACH20012890, UTERU10001600
  • The following 63 clones presumably belong to the category of ATP- and/or GTP-binding proteins.
  • 3NB6920002810, BNGH410000390, BRACE20022020, BRACE20028120, BRACE20071380, BRAWH20000480, BRAWH20006860, BRAWH20066220, CTONG20013200, DFNES20002680, FEBRA20043290, FEBRA20052160, FEBRA20072000, FEBRA20075510, HHDPC20000550, HLUNG20001160, HSYRA10001680, HSYRA20005100, HSYRA20006050, KIDNE20040840, MAMGL10001780, MESAN20002910, NB9N410001350, NT2NE20003690, NT2NE20005170, NT2NE20016660, NT2NE20055170, NT2RI20068550, NT2RI20073840, NT2RP70004250, NT2RP70011660, NT2RP70029060, NT2RP70036290, NT2RP70042600, NT2RP70046870, NT2RP70062960, NT2RP70081370, NT2RP70081440, NT2RP70093700, OCBBF20008240, OCBBF20015280, PEBLM20004790, PLACE50001700, PLACE60003790, PROST20018990, PROST20033400, SKMUS20008630, SMINT10000420, TESTI20001540, TESTI20003560, TESTI20005910, TESTI20006950, TESTI20006990, TESTI20008490, TESTI20015110, TESTI20016610, TESTI20022560, TESTI20029120, TESTI20034980, TESTI20042290, TESTI20047120, TESTI20049820, TESTI20057310
  • Among the clones other than the ones shown above, NTONG10001300 is a clone which was predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • FEBRA20017060, NT2RI20066790, SMINT10000710
  • The three clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
  • BRACE20080970, BRACE20092120, BRAWH10001300, FEBRA20019890, KIDNE20031850, KIDNE20060140, MESAN20000920, NB9N410000470, NT2RI20071480, NT2RI20078910, NT2RP70088550, NTONG20016120, OCBBF10000910, PROST20094830, SKNSH10003010, SPLEN20002670, TESTI20031960, TESTI20036250, TESTI20037810, TESTI20083870, TESTI20177400
  • The 21 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • 3NB6920009120, 3NB6920014710, BRACE10001660, BRACE20083850, BRAWH20004760, BRAWH20012030, CTONG20011390, CTONG20018200, FEBRA20007870, FEBRA20043250, HHDPC20003150, NT2RI10000270, NT2RI20036950, NT2RI20053680, NT2RI20072540, NT2RI20083360, NT2RP70030550, OCBBF20013070, OCBBF20015270, PLACE60046630, PROST10003430, PROST20067370, SKMUS10001040, SKNMC20015960, TESTI20030050, TESTI20033540, TESTI20035890, TESTI20068720, TRACH20004110
  • The 29 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
  • BNGH410001900, BRACE20080970, BRACE20092120, BRAWH20093600, FEBRA20003770, FEBRA20024290, HLUNG10000990, KIDNE20004030, MESAN20000920, NB9N420001040, NT2NE10000140, NT2NE20001740, NT2RI20050610, NT2RI20055640, NT2RI20072540, NT2RI20074690, NT2RP60000860, NT2RP70036470, NT2RP70036800, NT2RP70072210, NT2RP70074060, NT2RP70084870, NTONG10001300, NTONG10002640, NTONG20016120, OCBBF10000910, OCBBF10001190, OCBBF20007190, SKMUS20001170, SKMUS20016620, SKNMC20000970, SKNMC20015960, SYNOV10001280, TESTI20002380, TESTI20006270, TESTI20013300, TESTI20031520, TESTI20036250, TESTI20037810, TESTI20064830, TESTI20083870, TRACH20006750, TRACH20016070
  • The 43 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • NT2RI20064120
  • The 1 clone shown above is a clone which was predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • BRACE20083800, KIDNE20004970
  • The 2 clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • 3NB6920009120, 3NB6920014710, BRACE10001660, BRACE20083850, BRAWH20004760, BRAWH20012030, BRAWH20064500, CTONG20011390, CTONG20018200, FEBRA20007870, FEBRA20043250, HCASM20003070, HHDPC20003150, NT2RI10000270, NT2RI20036950, NT2RI20053680, NT2RI20072540, NT2RI20083360, NT2RP70012310, NT2RP70030550, NT2RP70036470, OCBBF20013070, OCBBF20015270, PLACE60046630, PROST10003430, PROST20067370, SKMUS10001040, SKNMC20000970, SKNMC20015960, TESTI20030050, TESTI20032280, TESTI20033540, TESTI20035890, TESTI20068720, TRACH20004110
  • The 34 clones shown above are clones which were predicted to highly possibly belong to the category of DNA- and/or RNA-binding protein based on the result of domain search by Pfam.
  • NT2RI20064120
  • The 1 clone shown above is a clone which was predicted to highly possibly belong to the category of ATP- and/or GTP-binding proteins based on the result of domain search by Pfam.
  • The 185 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search using their full-length nucleotide sequences and motif search in their estimated ORFs.
  • 3NB6910001160, ASTRO20004170, BNGH410000030, BNGH410001900, BRACE20005250, BRACE20014770, BRACE20016730, BRACE20017370, BRACE20024310, BRACE20028960, BRACE20077840, BRACE20083850, BRAWH20003230, BRAWH20009440, BRAWH20076050, CTONG20018200, CTONG20027210, CTONG20064490, DFNES20004320, FCBBF10006870, FCBBF20002760, FCBBF20012110, FEBRA20000530, FEBRA20005360, FEBRA20007570, FEBRA20011330, FEBRA20019890, FEBRA20030540, FEBRA20043250, FEBRA20044900, FEBRA20048180, FEBRA20053800, FEBRA20068730, FEBRA20070170, HCASM10000210, HCASM20005360, HHDPC20001150, HHDPC20001490, HLUNG10000990, HSYRA10001190, HSYRA20001350, HSYRA20006400, IMR3220002230, IMR3220014910, KIDNE10001520, KIDNE20003750, KIDNE20004970, KIDNE20005740, KIDNE20031850, KIDNE20043440, KIDNE20056760, KIDNE20059080, KIDNE20060140, KIDNE20060300, KIDNE20067750, LIVER10000790, LIVER10004330, MESAN10001010, MESAN20000920, NB9N410000470, NB9N420001040, NB9N420004950, NT2NE10000180, NT2NE10000630, NT2NE20013370, NT2NE20016970, NT2NE20035690, NT2NE20053710, NT2RI20006690, NT2RI20013420, NT2RI20013850, NT2RI20015190, NT2RI20016210, NT2RI20022700, NT2RI20025170, NT2RI20029260, NT2RI20029580, NT2RI20043040, NT2RI20061830, NT2RI20064120, NT2RI20065060, NT2RI20074690, NT2RI20077230, NT2RI20082210, NT2RI20083960, NT2RI20088120, NT2RP60000080, NT2RP60000350, NT2RP60000720, NT2RP60000860, NT2RP70009060, NT2RP70010800, NT2RP70022430, NT2RP70028290, NT2RP70033040, NT2RP70036320, NT2RP70036800, NT2RP70042330, NT2RP70049150, NT2RP70052050, NT2RP70055020, NT2RP70063040, NT2RP70072210, NT2RP70084410, NT2RP70084870, NTONG10000520, NTONG10001230, NTONG10001300, OCBBF10001220, OCBBF20007190, OCBBF20011400, OCBBF20014020, OCBBF20014940, PEBLM10001440, PEBLM20002130, PLACE50000370, PLACE50000800, PLACE60014430, PLACE60024190, PLACE60033990, PLACE60038500, PLACE60043970, PLACE60044640, PROST20023380, PROST20034720, PROST20067370, PROST20079740, SALGL10000470, SKMUS10000140, SKMUS10001040, SKMUS10001180, SKMUS20001170, SKMUS20003650, SKMUS20003900, SKMUS20004580, SKMUS20009020, SKMUS20009540, SKMUS20010080, SKMUS20011470, SKMUS20015430, SKMUS20016620, SKNMC20000970, SKNMC20015960, SMINT10001030, SMINT20001450, SMINT20003960, SMINT20004000, SPLEN20002670, SYNOV10001280, SYNOV20002910, SYNOV20008200, TESTI10000250, TESTI10000640, TESTI10001310, TESTI10001910, TESTI20000440, TESTI20002070, TESTI20002080, TESTI20014120, TESTI20016650, TESTI20022230, TESTI20022940, TESTI20024610, TESTI20027290, TESTI20030050, TESTI20030590, TESTI20030740, TESTI20035510, TESTI20035740, TESTI20041220, TESTI20052680, TESTI20054080, TESTI20064830, TESTI20065720, TESTI20068660, TESTI20071830, TESTI20078670, TESTI20083870, THYMU10000020, THYMU10002910, TRACH10000300, TRACH20006750, TRACH20007800, TRACH20008940, TRACH20013950
  • Further, the reason is that a polypeptide does not always belong solely to a single category of the above-described functional categories, and therefore, a polypeptide may belong to any of the predicted functional categories. Besides, additional functions can be found for the clones classified into these functional categories by further analyses.
  • Since the polypeptide encoded by clones of the invention contains full-length amino acid sequence, it is possible to analyze its biological activity, and its effect on cellular conditions such as cell proliferation and differentiation by expressing the polypeptide as a recombinant polypeptide using an appropriate expression system, injecting the recombinant into the cell, or raising a specific antibody against the polypeptide.
  • The biological activities of respective polypeptides can be analyzed by the methods as shown below.
  • Secretory Protein, Transmembrane Protein:
  • “Ion Channels” (Ed., R. H. Ashley, 1995) of “The Practical Approach Series” (IRL PRESS),
  • “Growth Factors” (Eds., I. McKay, I. Leigh, 1993),
  • “Extracellular Matrix” (Eds., M. A. Haralson, J. R. Hassell, 1995);
  • Glycoprotein-Related Protein:
  • “Glycobiology” (Eds., M. Fukuda, A. Kobata, 1993) of “The Practical Approach Series” (IRL PRESS),
  • “Glycoprotein Analysis in Biomedicine” (Ed., Elizabeth F. Hounsell, 1993) of “Method in Molecular Biology” (Humana Press) series;
  • Signal Transduction-Related Protein:
  • “Signal Transduction” (Ed., G. Milligan, 1992) of “The Practical Approach Series” (IRL PRESS),
  • “Protein Phosphorylation” (Ed., D. G. Hardie, 1993), or “Signal Transduction Protocols” (Eds., David A. Kendall, Stephen J. Hill, 1995) of “Method in Molecular Biology” (Humana Press) series;
  • Transcription-Related Protein:
  • “Gene Transcription” (Eds., B. D. Hames, S. J. Higgins, 1993) of “The Practical Approach Series” (IRL PRESS),
  • “Transcription Factors” (Ed., D. S. Latchman, 1993); Enzyme and/or metabolism-related protein:
  • “Enzyme Assays” (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON, 1992) of “The Practical Approach Series” (IRL PRESS); Cell division and/or cell proliferation-related protein:
  • “Cell Growth, Differentiation and Senescence” (Ed., GEORGE STUDZINSKI, 2000) of “The Practical Approach Series” (IRL PRESS);
  • Cytoskeleton-Related Protein:
  • “Cytoskeleton: Signalling and Cell Regulation” (Eds., KERMIT L. CARRAWAY and CAROLIE A. CAROTHERS CARRAWAY, 2000) of “The Practical Approach Series” (IRL PRESS),
  • “Cytoskeleton Methods and Protocols” (Ed., Gavin, Ray H., 2000) of “Method in Molecular Biology” (Humana Press) series; Nuclear protein and/or RNA synthesis-related protein:
  • “Nuclear Receptors” (Ed., DIDIER PICARD, 1999) of “The Practical Approach Series” (IRL PRESS),
  • “RNA Processing” (Eds., STEPHEN J. HIGGINS and B. DAVID HAMES, 1994);
  • Protein Synthesis and/or Transport-Related Protein:
  • “Membrane Transport” (Ed., STEPHEN A. BALDWIN, 2000) of “The Practical Approach Series” (IRL PRESS),
  • “Protein Synthesis Methods and Protocols” (Eds., Martin, Robin, 1998) of “Method in Molecular Biology” (Humana Press) series;
  • Cellular Defense-Related Protein:
  • “DNA Repair Protocols” (Henderson, Daryl S., 1999) of “Method in Molecular Biology” (Humana Press) series,
  • “Chaperonin Protocols” (Eds., Schneider, Christine, 2000); Development and/or differentiation-related protein:
  • “Developmental Biology Protocols” (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON, 1992) of “Method in Molecular Biology” (Humana Press) series;
  • DNA- and/or RNA-Binding Protein:
  • “DNA-Protein Interactions Principles and Protocols” (Eds., Kneale, G. Geoff, 1994) of “Method in Molecular Biology” (Humana Press) series,
  • “RNA-Protein Interaction Protocols” (Eds., Haynes, Susan R., 1999);
  • ATP- and/or GTP-Binding Protein:
  • “Signal Transduction Protocols” (Eds., David A. Kendall, Stephen J. Hill, 1995) of “Method in Molecular Biology” (Humana Press) series.
  • In the categorization, the clone predicted to belong to the category of secretory and/or membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it was a secretory or membrane protein, or a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane region was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • The clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • The clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • The clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • The clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, UniGene, or nr, where the hit data corresponds to genes or polypeptides which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database described later.
  • The clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • The clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • The clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • The clone predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • The clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • The clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • The clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • The clone predicted to belong to the category of DNA- and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • The clone predicted to belong to the category of ATP- and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • As to a protein involved in a disease, it is possible to perform a functional analysis as described above, but also possible to analyze correlation between the expression or the activity of the protein and a certain disease by using a specific antibody that is obtained by using expressed protein. Alternatively, it is possible to utilize the database OMIM, which is a database of human genes and diseases, to analyze the protein. Further, new information is constantly being deposited in the OMIM database. Therefore, it is possible for one skilled in the art to find a new relationship between a particular disease and a gene of the present invention in the most up-to-date database. The proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • Also, as for a secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein, etc., search of the OMIM with the following keywords resulted in the finding that the proteins are involved in many diseases (the result of the OMIM search for secrete and membrane proteins is shown below). Also, association between proteins associated to signal transduction or transcription and diseases is reported in “Transcription Factor Research-1999” (Fujii, Tamura, Morohashi, Kageyama, and Satake edit, (1999) Jikken-Igaku Zoukan, Vol. 17, No. 3), and “Gene Medicine” (1999) Vol. 3, No. 2). When cancer is used as an example, as described in “Biology of Cancer” (S. Matsubara, 1992) of Life Science series (Shokabo), many proteins are involved in cancers, which include enzyme and/or metabolism-related proteins, cytoskeleton-related proteins, cell division and/or cell proliferation-related proteins as well as secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins. As clearly seen by the above example, it is evident that not only disease-related proteins but also secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, etc. are often involved in diseases, and thus they can be useful targets in the field of medical industry.
  • The result of the OMIM search for secretory and membrane proteins is shown below, in which the keywords,
  • (1) secretion protein,
  • (2) membrane protein,
  • (3) channel, and
  • (4) extracellular matrix were used.
  • Shown in the search result are only the accession numbers in the OMIM. Using the number, data showing the relationship between a disease and a gene or protein can be seen. The OMIM data has been renewed everyday.
  • 1) Secretion Protein
  • 354 entries found, searching for “secretion protein”
  • *604667, *104760, *176860, *151675, *139320, *107400, *604029, *118910, #200100, *176880, *603850, *147572, *604028, *179513, *125950, *139250, *246700, *600946, *600560, *602926, 185860, *605083, *603215, *602421, *157147, *179512, *600174, *109270, *604710, *138120, *179510, *600998, *179509, *170280, *179511, *600626, *603831, *601489, *154545, *179490, *603826, *122559, *603216, *102720, *147290, *164160, *603062, *112262, *602672, *605435, *605322, *131230, *601652, *603166, *601746, *601591, *179508, #160900, *104311, *600759, *147545, *167805, #104300, *167770, #219700, *168470, *601684, *602049, *601146, *605227, *602434, *602534, *114840, *603489, *604323, *107470, *600753, *600768, *118825, *600564, *604252, *173120, *134370, *192340, *308230, *600322, *605359, *600046, *300090, 106160, *600041, #262500, *605563, *150390, *158106, *182590, #103580, *104610, #173900, *134797, *143890, #145980, *306900, *308700, *176300, *227500, *137350, #154700, *138079, *600760, *107730, *142410, *147670, *124092, *590050, *152760, *600509, *605646, *201910, *227600, *152790, *300200, *300300, 300800, *138160, *107741, *120150, *601199, *120180, *120160, *176730, *133170, *122560, *107300, *137241, *120140, *101000, *193400, *217000, *272800, *600937, #201710, *600377, #174800, *106100, #274600, *173350, #177170, *147620, *214500, *131244, *202110, *120120, *601007, *191160, *147470, *603372, *600733, *252800, *190160, *138040, *158070, *162151, #125700, #130070, *113811, *603355, *171060, *136435, #184700, *603732, *190180, *164008, *186590, *120220, *604312, *152200, *138130, *605085, *605353, *600840, #166210, *188545, *207750, *173360, *601933, #194050, *153450, *138850, *253200, *307030, *157145, *600514, *600262, *264080, *147380, *600281, #204000, #227810, *232200, *188826, *232800, *161561, #166200, *188400, *153620, *182099, *218040, #265800, *172400, #177200, *176805, #211600, #214700, #176410, *152780, *600633, *601771, *301500, *605402, *601922, *307800, *147892, *147720, *312060, #520000, *147660, *106150, *602358, *107270, *601769, *147440, *604558, *131530, *600270, *601610, *603692, *603401, *600423, *601604, *603345, #125853, *602843, *142640, *603044, *605740, *134830, *602779, *130660, *139191, *137035, *600761, *601340, *600823, *107740, *130160, *600877, *605110, *600945, *130080, *600957, #130050, *605580, *118444, *601124, *124020, 122470, *120700, *603201, *137216, *601185, *138945, *218030, *600839, #240600, #262400, #162300, *162330, *188450, #265850, *263200, *162641, *300159, *601038, #191390, *201810, *601398, *602384, *131240, *602423, *139392, *142703, *602663, *232700, *602682, #602722, *602730, *600734, *188540, *182452, *601538, *603061, *146880, *603140, *603160, *142704, #252650, *182280, *125255, *603252, #131750, *182139, *182100, #259420, #261100, *603493, *601745, *182098, *603795, *123812, *600264, *147940, *180246, *180245, *118888, #604284, *168450, *118455, *604398, *604433, *601919, *118445, *600031, *604961, *605032, *605033, *171050, #171300, *131243, *109160, *605254, 274900, #171400, *600042, *151670, *184600, *605470, *605546, *176760, *602008, *102200, *605720, *600732, *605901
  • 2) Membrane Protein
  • 1489 entries found, searching for “membrane protein”
  • *130500, *605704, *305360, *153330, *173610, *109270, *170995, *170993, *104776, *602333, *309060, *605703, *120920, *605943, *602690, *159430, *600897, *133090, *601178, *602413, *602003, *604405, *605940, *603237, *109280, *600378, *602173, *107776, *602334, *602335, *125305, *601134, *309845, *605731, *154045, *603241, *603718, *600594, *603214, *185881, *603657, *600182, *603177, *605331, *601476, *605456, *601114, *605190, *600723, *603904, *136950, *300222, *602879, *185880, *605348, *300096, *602257, *177070, *310200, *603062, *603344, *600039, *602977, *300100, *128240, *600959, *600322, *227400, *186945, *600946, *602534, *602048, *182900, *601097, *600267, *602625, *136430, *602421, *601047, *107450, *143450, *603141, *184756, *164730, *159440, *154050, *600579, *312080, *604202, *603700, *600447, *256540, *604691, *158343, *600403, *602414, *137290, *176640, *176981, *600179, *600754, *604456, *604693, *605875, *604605, *188860, *300172, *602910, *604323, *219800, *601848, *603179, *600279, *602251, #222700, *603831, *605072, *605377, *601028, *604155, *108733, *104225, *601896, *601510, *173335, *107770, *601767, *600046, *603850, *600040, *603784, *603234, 188560, *605863, *121015, *605862, *605861, *186946, *604252, *603215, *142461, *604597, *603143, *605264, *603735, *176860, *605536, *176801, *180721, *603355, *104760, *131560, *310300, *602631, *304700, #309400, *603142, *143890, *605431, *600753, *115501, *176790, *600266, *601691, *168468, *601239, *602216, #104300, *605613, *601595, *605550, *125950, *605475, *602217, *602261, *603534, *602262, *604631, *190315, *601313, *604306, *104311, *604672, *605000, *602461, *605548, *602296, *604376, *121014, *121011, *600691, *604262, *139310, *304040, *605445, *179514, *179512, *151460, #160900, *120130, *128239, *601158, *601403, *176943, *601014, 300800, *300294, *601757, *185470, *273800, *605034, *602887, #185000, *604871, *603593, *603583, *605454, *104775, *605872, *141180, *602713, *603531, *139150, *601531, *601832, *605452, *134651, *604156, *120620, *605883, *604142, *166945, *605324, *600816, *604699, *300112, *605182, *600164, *182180, *605071, *300023, *605057, *308240, *300249, *176947, *176894, *605081, *605035, *602044, *182860, *107271, *305100, *153390, *113730, *602689, *180069, *603518, *300017, *191275, *177061, *601693, *601789, *604241, *600934, *138160, *604424, *603868, *600174, *600718, *600523, *604141, *601009, *605251, *600481, *600874, *155550, *605227, *601017, *162230, 601138, *604157, *601212, *600763, *604110, *604158, *601107, *601326, 600621, *600587, 601137, *600917, *600855, *605058, *194355, *605194, *603291, *102720, *136425, *170715, *603216, *605547, *135630, *602926, *600168, *605002, *602474, *600157, *603025, *603893, *231200, *120090, *601966, *131230, *604722, *604721, *604515, *246700, *602101, *605628, *303630, *605787, *602857, *602285, *605708, *602488, *605025, *603817, *300051, *603293, *176878, *603646, 605707, 185860, *112205, *300187, *602654, *120070, *603648, *604850, *602655, *602514, *300118, *182309, *179590, *602701, *600759, *204200, *604170, *175100, #103580, *147670, *306400, *143100, *182870, *257220, *180380, #116920, *301000, *193300, *157147, *131550, *139200, *139130, *190195, *605406, *155760, *155960, *605734, *155970, *605385, *111700, *155975, *150370, 605709, *151430, *605438, *151510, *116952, *157655, *158105, *605777, *176877, *153619, *120131, *185430, *109190, *120190, *109170, *605093, *605250, *153432, *107777, *186590, *160993, *605699, *605698, *605813, *605697, *605616, *605300, *162060, *605219, *163970, *135620, *165040, *605478, *604964, *103195, *604932, *604923, *605906, *605496, *605914, *166490, 138277, *604915, *114070, *605213, *605933, *180297, *101000, *191163, *191164, *605101, *603167, *600772, *603164, *600708, *604001, *191328, *313440, *602672, *604009, *604299, *192974, *604256, *603048, *600515, *604221, *602632, *604196, *601179, 603290, *604661, *601023, *601110, *304800, *203200, *300212, *602933, *603352, *208900, *604418, *604838, *600551, #212140, *604837, *602049, *600552, *600553, *300213, *602574, *600583, *600932, *603452, *604775, *516020, *604617, *604464, *603498, *300145, *601523, *602694, *600632, *604762, *604492, *400015, *604504, *601717, *601728, *300242, *602426, *604194, *603821, *604730, *600695, *603823, *603869, *300241, *600707, *603822, *602370, *602202, *604193, *601181, *604089, *602507, *604195, *602306, *300284, *601805, *601895, *601275, *604660, *600752, *603820, *604192, *602207, *308230, *600894, *312600, *603199, *604029, *602500, *102680, *235200, #256300, *601633, #219700, 262890, *156225, *173470, *193400, *173910, *600354, *113705, *600065, *107741, *107400, *600024, *131195, *113811, #118220, *601638, *300011, *276903, *604144, *311770, *601758, #173900, *604592, *120120, *179605, *603130, *603372, *110750, *222900, *602509, *256100, *602469, *602281, *229300, *224100, *110900, *190180, *261600, *602997, *603616, *603189, 601791, *601567, *312700, *171060, *308700, *604027, *162643, *516000, *176261, *604028, *314850, #145980, *601383, *600930, *305900, *601253, *136350, *605537, *138140, *604033, *605070, *139250, *300500, *603967, *300041, *603866, #130600, *120150, *601050, *604942, *605204, *605248, *272750, *600163, *604235, *600682, *107266, *306900, *191092, #262500, *600106, *152790, *186720, *227650, *153700, *308380, *103390, *605646, *164920, *604478, #252650, *173850, *173350, *602505, *246530, *194380, *602575, *603030, #209920, *212138, #214100, *605767, *600582, *189980, #176200, *604653, *604678, *256550, *300037, *253700, #253300, #226700, *604766, #244400, *190000, *188040, *604824, *214500, #237500, *232300, *605014, *604477, *190930, *605124, *604475, *604594, #227810, *306700, #301050, *600135, *600143, *605145, #269920, *300104, *277900, *300135, *300231, *192500, *182138, *191190, *176805, *600185, *186591, *604889, *603051, *165360, *147545, *601040, #156575, *107269, *603009, *602934, *123825, *601081, *602924, *163890, *600381, *602909, *150330, *109690, *123900, *603434, *603491, *110700, *602581, *125647, #154700, *114760, *141900, *603690, *120220, *601199, #145500, *601309, *602382, *120325, *600877, *604205, *604090, *601497, *602377, *605464, *138720, *603728, *120950, *604026, *600580, *601610, *137167, *603960, *603931, *601880, *603126, *138190, *130130, *601997, *601975, *600395, *516040, *600418, *600650, *605245, *605172, *600509, *164761, *310400, *600308, *605109, *600544, *600359, *600103, *605267, *312610, *176100, *308100, *158070, *605123, *173325, #312750, *600839, *158120, #604369, *604465, *173510, #161200, *151525, *605369, *604237, *516050, #600886, *604517, *165180, *605381, *605399, *307800, *604365, *155740, *147795, 601709, *604673, *147730, *602122, *147557, *193245, *600978, *604990, *603261, *603274, *601007, *131100, *602941, *107941, *146710, *276901, *131244, *602872, *603411, *186357, *176290, *601066, *185050, *232200, *143030, *601843, #236700, *604122, *142800, *134638, *604985, *182380, *603930, *142410, *137060, *604586, *601193, *120650, *252500, *253800, *120930, *604858, *605874, 601274, *602158, *605873, *193210, *203100, *601295, *604095, #201710, *126150, *108740, #205400, *601373, *300167, *109545, *602894, *603361, #300257, *266200, *603401, *131390, *180470, *605908, *604798, #221770, *223360, *180901, *605641, *605745, *604018, *300200, *604603, *230800, *602676, #604004, *605692, *602640, *601599, *134637, *245900, *118425, 601614, *605725, *120110, *300189, *300035, *603102, *250800, *602282, *602458, *123610, *603754, *300278, *601463, *300224, *601581, *182160, *601653, *139191, *601733, *600748, *142460, *601194, *152390, *153620, *601615, *601814, *601617, *601613, *300191, #308300, *600798, 601858, *601872, *601597, #601588, *600821, *147840, *152427, *138850, *600823, *601492, *300256, *600840, *300267, *601411, *139080, *139090, 600851, *300334, *179080, *602095, *601284, *601282, #177200, *601681, *601252, *176000, *602184, *602188, #266510, #154020, *186711, *257200, *601711, *600667, *602241, *186745, *255125, *300126, *600644, *123890, #255120, #175200, *600004, *302060, *123580, *186760, *122561, *602316, *600017, *120940, 140300, *151690, *120700, *602354, *600019, *600857, *182175, *600536, *158380, *600516, *120290, *600493, *182310, #252010, *182530, *186830, *601839, *142790, *159465, *118990, *250790, *248600, #248250, *186845, *601153, *142600, *116930, *114860, *171834, #303600, *186880, *600444, *142871, *601852, *602602, *602607, *114207, *186910, #232220, 600880, *134635, *112203, #112100, *111680, *231680, *311030, *111250, *111200, *134390, #226670, #145600, *226200, *602714, *171760, *133550, *602727, *161555, *602744, *602746, #131705, *602835, *600423, *176267, *602859, #600918, 277175, *602874, *601020, *109770, *600170, *217070, *173515, *602893, *147280, *154360, *171050, *108780, *176257, *600979, *600377, *108360, *204500, *170260, *146880, *154582, *601011, *600997, *602992, *201475, *603005, *190198, *147360, #270400, *600238, #164970, *306250, #126600, *193065, #181350, *106180, *602136, *600937, *603086, *603087, *307030, *182099, *103320, *601683, #192430, *103180, *102681, *192321, *600244, *191740, *191315, *603152, *102642, *191305, #266140, *100500, *600867, *604585, *604404, *604345, *603201, *605430, *603207, *603208, *605433, *604101, *603969, *605896, *604616, *605851, *605768, *604576, *605754, *605730, *605477, *603263, *605538, *603283, *604402, *605453, *605427, *603302, *605458, 603313, *604415, *603345, *605541, *603353, *605295, *603879, *605268, *605266, *605246, *603377, *603380, *605181, *604203, *603425, *603867, *605106, *605017, *603842, *604936, *603510, *604857, *605932, *605816, *603765, *603551, *605357, *605237, *604204, *603594, *605110, *604190, *603861, *604962, *603639, *603644, *605007, *605349, *604943, *604918, *604907, *603667, *603681, *605396, *605561, *603712, *603713, *605688, *605942, *604878, *604843, *604659, *604671, *603798, *604682, *604056, *604705, *603749, 602586, *603647, *602515, #602475, *603717, *602359, *602372, *602380, *602518, *603652, *602573, *603626, 602587, *603598, *602871, *603613, *603750, *603875, *602608, *602666, *602345, *602935, *603564, *603548, *603927, 601876, *602343, *603943, *603787, *601730, *601611, *602679, *603788, *602243, 603790, *601535, *603796, *601488, *601485, *602314, *601478, *604047, *604048, *602297, *604057, *602715, *602192, *601459, *601416, *603833, *602190, *604102, *602106, *604111, *602724, *603499, *602736, *601123, *601002, *600923, *601987, *604149, *601929, *600910, *600900, *600864, *604165, *600782, *602836, *600769, *600742, *602783, *601905, *600535, *604198, *601901, *600534, *602876, *603356, *600530, *604216, *604217, *602890, *602905, *600465, *600464, *600446, *602891, *603366, *601894, *604272, *603926, *603312, *600368, *602914, *600327, *603151, *603202, 602911, *602974, *603006, *601883, *603008, *600074, *603007, *603046, #603903, *604433, *600016, *603925, *516005, *516004, *516003, *601756, *604487, *516001, *313475, *313470, #307810, *604527, *604528, *601745, *604551, *604555, *603243, *603242, *603061, *603063, *603217, *300335, *300283, *300281, *604600, *300197, *603097, *603220, *601625, *604623, *603118, *601590, *604646, *300008, *601568, *300007, *275630, *601533, #275200, *270200, #261550, *604031, *604683, #254800, *251100, #242300, *604058, *604720, *240500, *233690, #232240, #226730, *223100, *222100, #220100, *216950, *604832, 212750, 212067, *604066, *193067, 601315, *193001, *604862, *604870, *191306, *600385, *604879, *191191, *601296, *604914, *190181, *604119, #188550, *604925, *188410, #601287, *604939, *188380, *604126, *604945, *604148, *188060, *604982, *186854, *604988, *186360, *186355, *185250, *600916, *605008, *605009, 185020, *600734, *605024, *182331, *605032, *605033, *182305, *180903, #179800, *179610, *605060, *179410, *178990, *176802, *605080, *176266, *176263, *176260, *600732, *173490, *604199, *173445, *173391, 172290, *605147, *605149, *171890, *600528, *171833, *605185, #170500, *605193, #168000, *605196, *167055, *605205, *605208, 166900, *605216, *162651, *162010, *600504, #161400, *604253, #160800, *159460, *154540, *605254, *605261, *153634, *600429, *153337, *600424, *605292, #604286, #152700, 152423, *152310, *151625, *600153, *604313, *151523, *150325, *150320, *150292, *603150, *150290, *150210, *605410, *605415, *605416, *605417, *605421, *603149, *604349, *147940, *600282, *147880, *146928, *146661, *600150, *146630, *142622, *600018, *605461, *138981, *138590, *600023, *138330, *605495, *138297, *605512, *138230, #136900, #301310, *516006, *605545, *605546, *136131, *134660, *134350, *516002, *605589, *131235, #130050, *605625, *126455, *126064, #125310, *605670, *604534, *125240, *123836, *123830, *123620, *605702, #122200, *120980, *120360, *118510, *114835, *605710, *605716, *605722, *114217, *604561, *113810, *111740, #110800, *605748, *605752, *604564, *110600, *603160, *109610, *605784, #107480, *107273, *603192, *300169, *106195, *105210, *104615, *104614, *104210, *103850, 103581, *605876, *605877, *605879, *103220, *605887, *300150, *102910, *102670, *102576, *605916, *604629, *102575, *102573, *300132, *101800, *605947
  • 3) Channel (Member of Membrane Protein)
  • 361 entries found, searching for “channel”
  • *176266, *600724, *182390, *123825, *114208, *114206, *176267, *114205, *601784, *600937, *114204, *603415, *600053, *114207, *114209, *605427, *604527, *604528, *600760, *601011, *192500, *118425, *600228, *176261, *602235, *600761, *600359, *300008, *182389, *600877, *602232, *176263, *182391, *601328, *600054, *603939, *602208, *601534, *600504, *602323, *603208, *601958, *603537, *601012, *601327, *600734, *602780, *602781, *604433, *603220, *182392, *605874, *605873, *601745, *603888, *603219, *602604, *603796, *302910, *602866, *601013, *602905, *602906, *603967, *600163, #170500, *152427, *180901, *176260, #601462, *603951, *601141, *604492, *600702, *602023, *600308, *602754, *107776, *176257, *602024, *601949, *605222, *601142, *602983, *193245, *600681, *176265, *600235, *176262, *176258, *605206, *604427, *605411, *603305, *601219, *600150, *604065, *602343, *605223, *605720, *603906, *138249, *138253, *600843, *604385, *600003, *600935, *603940, *602727, *602158, 602911, *600397, *602726, *600845, *605080, *600580, *602872, *602106, *176264, *603953, *605722, *300110, *138252, *604111, *602717, *602420, *600570, 600844, *603493, *600932, *605716, *138254, *603652, *300138, *605410, *176268, *605214, *605696, *300334, *604660, *176256, *605879, *603749, *603583, *602345, *604661, *603787, 603313, *602982, *604337, *600846, *604662, *300328, *300281, *602566, *602836, *604003, *603788, *603651, *602421, *107777, #177200, *100725, #219700, *100690, *100710, #160800, #603830, #183086, *600509, #220400, #601144, *173910, *180902, *605692, #264350, #160900, #145600, #255700, *602076, *603061, *601313, *154275, #604233, *604532, #108500, #121201, #170400, *300225, *121014, *139311, #125800, #160120, *118503, 601439, #141500, #168300, *304040, #601887, #256450, *186945, *154276, #300009, #216900, *600040, *601014, *601042, *602512, *601383, *605445, *602368, *603831, #117000, *601218, *108745, *605248, #177735, #173900, *601212, *182139, *601059, *600039, *601485, *180903, *186360, *603319, #600101, *118509, *600109, #121200, *600170, *604187, *176975, *137163, #310468, #263800, #262300, *603750, *600229, *124030, *602251, #603829, *137143, #145500, *600669, *147450, *154050, *603353, *600516, *601157, *600855, *601154, *602522, *249210, *600968, #252650, *171060, *600919, *156490, #259700, #601678, *601764, #310500, *131244, *300041, *121011, *125950, *114180, *602974, *600637, *113730, *118504, *605145, *604669, *118800, *121013, *121015, *138491, *600421, *104610, *604045, *604594, *131230, *605487, *138247, *600467, #602485, *602481, *138251, *137192, *602403, 600851, *277900, *603785, *603152, *603199, *603475, #168600, #272120, *170280, *603852, #241200, *603053, *600465, #603034, *142461, *164920, *137164, *600884, *600442, *123885, *604001, *600232, *232200, *171050, *602103, *602014, *300211, *600983, *602887, *604415, *604418, *300242, #300071, *604471, *600837, 168350, *118511, 193007, *600300, *604654, #601820, *180297, *600046, *603853, *604678, *604693, #604772, *118508, *603855, *605204, #254210, *182099, *182307, #130600, *601109, *114080, *300103, *182860, *605438, *601129, *603964, *600019, *516060, #185000, *138079, *104210, *605818, *603418, *305990, *305450
  • 4) Extracellular Matrix
  • 218 entries found, searching for “extracellular matrix”
  • *605912, *603479, *602201, *604633, *601418, *601548, *115437, *154870, *600754, *602261, *602285, *602262, *134797, *120361, *604629, *604871, *603321, *603320, *601807, #154700, *116935, *185261, *120360, *185250, *605470, *603767, *253700, *190180, *128239, *308700, *276901, *193300, *120324, *188826, *602109, *155760, *600514, *600261, #177170, *600536, *147557, #116920, *150240, *601313, *120140, 601614, *605158, *120150, *120180, #200610, *605127, *193400, *192240, #173900, *152200, #136900, *135821, #130070, *120320, *120220, *112260, *310200, *600900, *600262, *605670, *600985, *179590, #245150, *602574, *601463, 183850, *601211, *604241, *600758, *186745, *604710, *602369, *602090, *190182, *192975, *602178, *230740, *600065, *601652, *158106, *190181, *156790, #158810, *193210, *155120, *192977, *193065, #226700, *187380, *231050, *182120, *188060, *186355, 163200, *164010, #156550, *151510, *150370, *253800, *156225, *150325, #194050, *150290, *216550, *147620, *600215, *222600, *147559, *165380, *182888, *600491, *146650, *146640, *600564, *600596, *600616, *600700, *600742, *138297, *182889, *154705, *600930, *301870, *153619, *601050, *601090, *601105, *165070, *305370, *135820, *130660, *310300, *601492, *128240, *601587, #126600, *601636, *600119, *601692, *601728, *125485, 601858, *601915, *602048, *175100, *602108, *121010, *600245, *120470, *120328, *120325, *602264, *120280, *602366, *600309, *602402, *602415, *602428, *602453, *602505, #166210, *602600, *602941, *603005, *603196, 603209, *603221, *603234, *603319, *120250, *120210, *120120, *603489, *603551, *118938, *603799, *603842, *603924, *603963, *604042, *604063, *604149, *604160, *601028, *604467, *604510, *604592, *116930, *116806, *601284, *604724, *604806, *604807, *604808, *107269, *605007, *605008, *605009, *600214, *600076, *605174, *605175, *605292, *605343, *605351, #600204, *605497, *605546, *605587, *605623, *600211, *605702, *103320
  • In addition to these, the various keywords shown in the above-mentioned categorization or others can be used for the OMIM search and the result may suggest the involvement thereof in diseases.
  • Further, the use of nucleotide sequences of cDNAs of the present invention enables analyzing the expression frequency of genes corresponding to the cDNAs. In addition, functions of the genes can be predicted based on the information obtained by the expression frequency analysis.
  • There are several methods for analyzing the expression levels of genes involved in diseases. Differences in gene expression levels between diseased and normal tissues are studied by the analytical methods using, for example, Northern hybridization, RT-PCR, DNA microarray, etc. (Experimental Medicine, Vol. 17, No. 8, 980-1056 (1999); Cell Engineering (additional volume) DNA Microarray and Advanced PCR Methods, Muramatsu & Nawa (eds.), Shujunsya (2000)). By computer analysis, in addition to these analysis methods, the nucleotide sequences of expressed genes can be compared to analyze the expression frequency. For example, there is a database called “BODYMAP”; gene clones are extracted at random from cDNA libraries of various tissues and/or cells, and the clones homologous to one another are assigned to a single cluster based on the information of nucleotide sequence homology at the 3′-end; genes are classified into any clusters, and the numbers of clones in the respective clusters are compared to gain the information on expression frequency (http://bodymap.ims.u-tokyo.ac.jp/).
  • When explicit difference in the expression levels between diseased tissues and normal tissues is observed for a gene by these analytical methods, it can be conclude that the gene is closely involved in a disease or disorder. Instead of diseased tissues, when gene expression is explicitly different between normal cells and cells reproducing disease-associated specific features, it can be concluded that the gene is closely involved in a disease or disorder.
  • From the 1639 clones whose full-length nucleotide sequences had been revealed, genes involved in particular pathology or functions were selected by the use of databases shown below (see Example 7; “Expression frequency analysis in silico”). The database used in the analyses of the present invention contains nucleotide sequences of 770,546 clones, and the population of the database is large enough for the analysis. The sequence information in the database was obtained by selecting cDNA clones at random from cDNA libraries derived from the various tissues and cells shown in Example 1 and determining the 5′-end sequences thereof.
  • Then, the nucleotide sequences of respective clones in this database were categorized (clustered) based on the nucleotide sequence homology determined with a search program; the number of clones belonging to every cluster of each library was determined and normalized; thus, the ratio of a certain gene in a cDNA library was determined. This analysis provided the information of the expression frequency of a gene in a tissue or cell that is the source of the cDNA library.
  • Then, in order to analyze the expression of genes corresponding to the nucleotide sequences of cDNAs of the present invention in tissues and cells, the libraries from the tissues or cells, which had been used in the large-scale cDNA analyses, were taken as subjects to compare the expression levels between different tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues or cells from which 600 or more cDNA clones whose nucleotide sequences had been analyzed were derived. The result of this analysis showed that the cDNA clones corresponded to the genes involved in the pathology and functions, which are indicated below. Each value in Tables 3 to 39 indicated below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis-Related Genes
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset correlates to the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism. Thus, the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line (Molecular Medicine 38. 642-648. (2001)) are genes involved in bone metabolism involved in osteoporosis.
  • A nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line. The result of comparative analysis for the frequency between the cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were 41 clones indicated in Table 3. These clones are involved in osteoporosis.
  • Genes Involved in Neural Cell Differentiation
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • A survey was performed for genes whose expression levels are varied in response to induction of differentiation (stimulation by retinoic acid (RA) or growth inhibitor treatment after RA stimulation) in cultured cells of a neural strain, NT2. The result of comparative analysis of cDNA libraries derived from undifferentiated NT2 cells (NT2RM) and the cells subjected to the differentiation treatment (NT2RP, NT2RI or NT2NE) showed that the genes whose expression levels were different between the two were 500 clones indicated in Table 4. These genes are neurological disease-related genes.
  • Cancer-Related Genes
  • It has been assumed that, distinct from normal tissues, cancer tissues express a distinct set of genes, and thus the expression thereof can contribute to the carcinogenesis in tissues and cells. Thus, genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • The result of comparative analysis of cDNA libraries derived from breast tumor (TBAES) and normal breast (BEAST) showed that the genes whose expression levels were different between the two were 11 clones indicated in Table 5.
  • The result of comparative analysis of cDNA libraries derived cervical tumor (TCERX) and normal cervical duct (CERVX) showed that the genes whose expression levels were different between the two were 10 clones indicated in Table 6.
  • The result of comparative analysis of cDNA libraries derived from colon tumor (TCOLN) and normal colon (COLON) showed that the genes whose expression levels were different between the two were 5 clones indicated in Table 7.
  • The result of comparative analysis of cDNA libraries derived from esophageal tumor (TESOP) and normal esophagus (NESOP) showed that the genes whose expression levels were different between the two were 5 clones indicated in Table 8.
  • The result of comparative analysis of cDNA libraries derived from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the genes whose expression levels were different between the two were 205 clones indicated in Table 9.
  • The result of comparative analysis of cDNA libraries derived from liver tumor (TLIVE) and normal liver (LIVER) showed that the genes whose expression levels were different between the two were 35 clones indicated in Table 10.
  • The result of comparative analysis of cDNA libraries derived from lung tumor (TLUNG) and normal lung (HLUNG) showed that the genes whose expression levels were different between the two were 62 clones indicated in Table 11.
  • The result of comparative analysis of cDNA libraries derived from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes whose expression levels were different between the two were 7 clones indicated in Table 12.
  • The result of comparative analysis of cDNA libraries derived from stomach tumor (TSTOM) and normal stomach (STOMA) showed that the genes whose expression levels were different between the two were 41 clones indicated in Table 13.
  • The result of comparative analysis of cDNA libraries derived from uterine tumor (TUTER) and normal uterus (UTERU) showed that the genes whose expression levels were different between the two were 94 clones indicated in Table 14.
  • The result of comparative analysis of cDNA libraries derived from tongue cancer (CTONG) and normal tongue (NTONG) showed that the genes whose expression levels were different between the two were 178 clones indicated in Table 15.
  • These genes are involved in cancers.
  • Further, there is a method to search for genes involved in development and differentiation, which is the expression frequency analysis in which the expression levels of genes are compared between developing and/or differentiating tissues and/or cells and adult tissues and/or cells. The genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • By using the information of gene expression frequency gained from the database of 5′-end nucleotide sequences described above, genes involved in development or differentiation of particular tissues were selected from the 1639 clones whose full-length nucleotide sequence had been revealed (see Example 7).
  • The result of comparative analysis of cDNA libraries derived from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE, BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA) showed that the genes whose expression levels were different between the two were 745 clones indicated in Tables 16 to 36.
  • The result of comparative analysis of cDNA libraries derived from fetal heart (FEHRT) and adult heart (HEART) showed that the genes whose expression levels were different between the two were 54 clones indicated in Table 37.
  • The result of comparative analysis of cDNA libraries derived from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the genes whose expression levels were different between the two were 145 clones indicated in Table 38.
  • The result of comparative analysis of cDNA libraries derived from fetal lung (FELNG) and adult lung (HLUNG) showed that the genes whose expression levels were different between the two were 63 clones indicated in Table 39. These genes are involved in regeneration of tissues and/or cells.
  • The expression frequency or the like can be analyzed by PCR based on the nucleotide sequences of cDNAs of the present invention. There are some known methods for comparing the quantities of amplification products obtained by PCR. For example, the band intensities can be determined by ethidium bromide staining. With RI-labeled or fluorescently labeled primers, the RI signal or fluorescence intensity can be assayed for the quantity of labeled amplification products. Alternatively, the quantity of amplification products can also be determined by measuring the RI signal or the fluorescence intensity from the RI-labeled or fluorescently labeled probe hybridizing to the products. The assay results thus obtained are compared and then the clones exhibiting differences in the expression levels can be selected.
  • There are some quantitative PCR methods: a PCR method using internal standards; a competitive PCR, in which the quantification is achieved by adding, to a sample, a dilution series of a known quantity of a template RNA and by comparing the quantity of an amplification product derived from the RNA of interest with the quantity of an amplification product derived from the template RNA. These methods overcome the problems of errors in the amount of amplification products among tubes and of the plateau effect. ATAC-PCR (Adaptor-tagged competitive PCR) is a method of competitive PCR which is practiced by using multiple adapters of different sizes attached to a gene whose 3′-end nucleotide sequence has previously been determined. The ratio of expression frequency of a single mRNA species from a number of tissues (cells) can be assayed in a single step (Nucleic Acids Research 1997, 25(22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112).
  • If it is observed, by using these analytical methods, that the expression levels of genes are evidently varied during major cellular events (such as differentiation and apoptosis), the genes are involved in the cellular events and accordingly are candidates for disease- and/or disorder-related genes. Further, genes exhibiting tissue-specific expression are genes playing important parts in the tissue functions and, therefore, can be candidates for genes involved in diseases and/or disorders affecting the tissues.
  • For example, inflammation is an important biological response that is known to be involved in various diseases. The representative inflammation-inducing factors include TNF-α (Tumor Necrosis Factor-alpha), LPS (Lipopolysaccharides), etc. Many genes have been identified as genes located downstream of the TNF-α or LPS stimulation. The respective stimulations are transduced through independent pathways of signaling cascade. There exists another signaling cascade for both stimulations, wherein NF-κB is a common transducing molecule shared by the two stimulations (Cell 1995, 80:529-532). It has also been revealed that many inflammation-related genes, including IL-2, IL-6 and G-CSF, are varied in the expression levels thereof in response to the signal through the common pathway (Trends Genet. 1999, 15(6): 229-235). It is assumed that genes whose expression levels are varied in response to the stimulation of TNF-α or LPS also participate in inflammation.
  • Further, the infection of Helicobacter pylori to the gastric epithelia is known to cause gastritis and gastroduodenal ulcer (Mebio 2000, Jul., 17(7): 16-33). Thus, the genes whose expression levels are altered depending on co-culturing cells with Helicobacter pylori may be involved in gastritis and gastroduodenal ulcer. A recent study has suggested that Helicobacter pylori strongly activates the NF-κB pathway, via the TRAF2/6-IKKβ pathway, namely, via the same pathway shared by TNF-α (Gastroenterology 2000, 119: 97-108).
  • THP-1 cell, which is a human monocyte cell line, was cultured in the presence of TNF-α (Tumor Necrosis Factor-alpha) or LPS (Lipopolysaccharides). The genes whose expression levels were altered owing to the presence of the agent were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of TNF-α were ADRGL10000180, BRACE20030780, BRACE20077640, BRACE20083850, BRAWH20004430, FCBBF10006180, FEBRA20003780, FEBRA20006800, FEBRA20012940, FEBRA20015840, HEART20004480, HLUNG10000370, HLUNG20001160, HSYRA20013320, IMR3220008380, KIDNE10001520, KIDNE20040540, KIDNE20061490, KIDNE20062990, NT2NE10001630, NT2NE20003920, NT2NE20005500, NT2RI20014500, NT2RI20016570, NT2RI20078270, NT2RI20083360, NTONG10002570, PUAEN10003220, SKNMC10000290, STOMA20002570, TESTI20011340, UTERU20004850.
  • On the other hand, the clones whose expression levels were decreased owing to the presence of TNF-α were BRACE20013400, BRACE20091880, HEART20005060, HLUNG20001760, IMR3220008590, NT2NE10001850, NT2RI20018660, NT2RI20053350, NT2RI20070480, PLACE60047380, STOMA20002890, SYNOV20001770, TRACH20001960.
  • Further, the clones whose expression levels were increased owing to the presence of LPS were FCBBF10006180, FEBRA20015840, HLUNG10000370, HLUNG20001160, HSYRA20013320, KIDNE20040540, KIDNE20061490, NT2NE10001630, NT2NE20003920, NT2NE20005500, NT2RI20014500, NT2RI20016570, NT2RI20078270, NTONG10002570, PUAEN10003220, STOMA20002570, TESTI20011340. On the other hand, the clones whose expression levels were decreased owing to the presence of LPS were BRACE20013400, BRACE20091880, HEART20005060, HLUNG20001760, NT2RI20070480, UMVEN20001330.
  • These clones are involved in inflammation.
  • MKN45, which is a gastric cancer cell line, was co-cultured with Helicobacter pylori. The genes whose expression levels were altered owing to the presence of Helicobacter pylori were searched for, and the result showed that the clones whose expression levels were increased owing to the presence of Helicobacter pylori were BRACE10001590, BRACE20079530, BRAWH10001620, FEBRA20006800, KIDNE20003490, KIDNE20040540, KIDNE20050420, NT2NE10001850, STOMA20002890, SYNOV20001770, TESTI10000550, UTERU20004850. On the other hand, the clones whose expression levels were decreased owing to the presence of Helicobacter pylori were BRACE20034490, BRACE20077640, BRACE20083850, KIDNE20005170, LIVER20000330, NT2RP60000390, NTONG10000980, UMVEN20001330.
  • These clones are involved in gastritis or gastroduodenal ulcer.
  • For example, if the polypeptide encoded by the cDNA of the present invention is a regulatory factor of cellular conditions such as growth and differentiation, it can be used for developing medicines as follows. The polypeptide or antibody provided by the invention is injected into a certain kind of cells by microinjection. Then, using the cells, it is possible to screen low molecular weight compounds, etc. by measuring the change in the cellular conditions, or the activation or inhibition of a particular gene. The screening can be performed as follows.
  • First, the polypeptide is expressed and purified as recombinant. The purified polypeptide is microinjected into cells such as various cell lines, or primary culture cells, and the cellular change such as growth and differentiation can be examined. Alternatively, the induction of genes whose expression is known to be involved in a particular change of cellular conditions may be detected by the amount of mRNA or polypeptide. Alternatively, the amount of intracellular molecules (low molecular weight compounds, etc.) that is changed by the function of the gene product (polypeptide) which is known to be involved in a particular change of cellular conditions may be detected. The compounds to be screened (both low and high molecular compounds are acceptable) can be added to the culture media and assessed for their activity by measuring the change of the cellular conditions.
  • Instead of microinjection, cell lines introduced with the gene obtained in the invention can be used for the screening. If the gene product is turn out to be involved in a particular change in the cellular conditions, the change of the product can be used as a measurement for screening. Once a compound is screened out which can activate or inhibit the function of the polypeptide of the invention, it can be applied for developing medicines.
  • If the polypeptide encoded by the cDNA of the present invention is a secretory protein, membrane protein, or protein involved in signal transduction, glycoprotein, transcription, or diseases, it can be used in functional assays for developing medicines.
  • In case of a membrane protein, it is most likely to be a polypeptide that functions as a receptor or ligand on the cell surface. Therefore, it is possible to reveal a new relationship between a ligand and receptor by screening the membrane protein of the invention based on the binding activity with the known ligand or receptor. Screening can be performed according to the known methods.
  • For example, a ligand against the polypeptide of the invention can be screened in the following manner. Namely, a ligand that binds to a specific polypeptide can be screened by a method comprising the steps of: (a) contacting a test sample with the polypeptide of the invention or a partial peptide thereof, or cells expressing these, and (b) selecting a test sample that binds to said polypeptide, said partial peptide, or said cells.
  • On the other hand, for example, screening using cells expressing the polypeptide of the present invention that is a receptor protein can also be performed as follows. It is possible to screen receptors that is capable of binding to a specific polypeptide by using procedures (a) attaching the sample cells to the polypeptide of the invention or its partial peptide, and (b) selecting cells that can bind to the said polypeptide or its partial peptide.
  • In a following screening as an example, first the polypeptide of the invention is expressed, and the recombinant polypeptide is purified. Next, the purified polypeptide is labeled, binding assay is performed using a various cell lines or primary cultured cells, and cells that are expressing a receptor are selected (Growth and differentiation factors and their receptors, Shin-Seikagaku Jikken Kouza Vol. 7 (1991) Honjyo, Arai, Taniguchi, and Muramatsu edit, p 203-236, Tokyo-Kagaku-Doujin). A polypeptide of the invention can be labeled with RI such as 125I, and enzyme (alkaline phosphatase etc.).
  • Alternatively, a polypeptide of the invention may be used without labeling and then detected by using a labeled antibody against the polypeptide. The cells that are selected by the above screening methods, which express a receptor of the polypeptide of the invention, can be used for the further screening of an agonists or antagonists of the said receptor.
  • Once the ligand binding to the polypeptide of the invention, the receptor of the polypeptide of the invention or the cells expressing the receptor are obtained by screening, it is possible to screen a compound that binds to the ligand and receptor. Also it is possible to screen a compound that can inhibit both bindings (agonists or antagonists of the receptor, for example) by utilizing the binding activities.
  • When the polypeptide of the invention is a receptor, the screening method comprises the steps of (a) contacting the polypeptide of the invention or cells expressing the polypeptide of the invention with the ligand, in the presence of a test sample, (b) detecting the binding activity between said polypeptide or cells expressing said polypeptide and the ligand, and (c) selecting a compound that reduces said binding activity when compared to the activity in the absence of the test sample. Furthermore, when the polypeptide of the invention is a ligand, the screening method comprises the steps of (a) contacting the polypeptide of the invention with its receptor or cells expressing the receptor in the presence of samples, (b) detecting the binding activity between the polypeptide and its receptor or the cells expressing the receptor, and (c) selecting a compound that can potentially reduce the binding activity compared to the activity in the absence of the sample.
  • Samples to screen include cell extracts, expressed products from a gene library, synthesized low molecular compound, synthesized peptide, and natural compounds, for example, but are not construed to be listed here. A compound that is isolated by the above screening using a binding activity of the polypeptide of the invention can also be used as a sample.
  • A compound isolated by the screening may be a candidate to be an agonist or an antagonist of the receptor of the polypeptide. By utilizing an assay that monitors a change in the intracellular signaling such as phosphorylation which results from reduction of the binding between the polypeptide and its receptor, it is possible to identify whether the obtained compound is an agonist or antagonist of the receptor. Also, the compound may be a candidate of a molecule that can inhibit the interaction between the polypeptide and its associated proteins (including a receptor) in vivo. Such compounds can be used for developing drugs for precaution or cures of a disease in which the polypeptide is involved.
  • Secretory proteins may regulate cellular conditions such as growth and differentiation. It is possible to find out a novel factor that regulates cellular conditions by adding the secretory protein of the invention to a certain kind of cell, and performing a screening by utilizing the cellular changes in growth or differentiation, or activation of a particular gene.
  • The screening can be performed, for example, as follows. First, the polypeptide of the invention is expressed and purified in a recombinant form. Then, the purified polypeptide is added to a various kind of cell lines or primary cultured cells, and the change in the cell growth and differentiation is monitored. The induction of a particular gene that is known to be involved in a certain cellular change is detected by the amounts of mRNA and polypeptide. Alternatively, the amount of an intracellular molecule (low-molecular-weight compounds, etc.) that is changed by the function of a gene product (polypeptide) that is known to function in a certain cellular change is used for the detection.
  • Once the screening reveals that the polypeptide of the invention can regulate cellular conditions or the functions, it is possible to apply the polypeptide as a pharmaceutical and diagnostic medicine for related diseases by itself or by altering a part of it into an appropriate composition.
  • As is above described for membrane proteins, the secretory protein provided by the invention may be used to explore a novel ligand-receptor interaction using a screening based on the binding activity to a known ligand or receptor. A similar method can be used to identify an agonist or antagonist. The resulting compounds obtained by the methods can be a candidate of a compound that can inhibit the interaction between the polypeptide of the invention and an interacting molecule (including a receptor). The compounds may be able to use as a preventive, therapeutic, and diagnostic medicine for the diseases, in which the polypeptide may play a certain role.
  • Proteins involved in signal transduction or transcription may be a factor that affects a certain polypeptide or gene in response to intracellular/extracellular stimuli. It is possible to find out a novel factor that can affect a polypeptide or gene by expressing the polypeptide provided by the invention in a certain types of cells, and performing a screening utilizing the activation of a certain intracellular polypeptide or gene.
  • The screening may be performed as follows. First, a transformed cell line expressing the polypeptide is obtained. Then, the transformed cell line and the untransformed original cell line are compared for the changes in the expression of a certain gene by detecting the amount of its mRNA or polypeptide. Alternatively, the amount of an intracellular molecule (low molecular weight compounds, etc.) that is changed by the function of a certain gene product (polypeptide) may be used for the detection. Furthermore, the change of the expression of a certain gene can be detected by introducing a fusion gene that comprises a regulatory region of the gene and a marker gene (luciferase, β-galactosidase, etc.) into a cell, expressing the polypeptide provided by the invention into the cell, and estimating the activity of a marker gene product (polypeptide).
  • If the polypeptide or gene of the invention is involved in diseases, it is possible to screen a gene or compound that can regulate its expression and/or activity either directly or indirectly by utilizing the polypeptide of the present invention.
  • For example, the polypeptide of the invention is expressed and purified as a recombinant polypeptide. Then, the polypeptide or gene that interacts with the polypeptide of the invention is purified, and screened based on the binding. Alternatively, the screening can be performed by adding with a compound of a candidate of the inhibitor added in advance and monitoring the change of binding activity. In another method, a transcription regulatory region locating in the 5′-upstream of the gene encoding the polypeptide of the invention that is capable of regulating the expression of other genes is obtained, and fused with a marker gene. The fusion is introduced into a cell, and the cell is added with compounds to explore a regulatory factor of the expression of the said gene.
  • The compound obtained by the screening can be used for developing pharmaceutical and diagnostic medicines for the diseases in which the polypeptide of the present invention is involved. Similarly, if the regulatory factor obtained in the screening is turn out to be a polypeptide, compounds that can newly affect the expression or activity of the polypeptide may be used as a medicine for the diseases in which the polypeptide of the invention is involved.
  • If the polypeptide of the invention has an enzymatic activity, regardless as to whether it is a secretory protein, membrane protein, or proteins involved in signal transduction, glycoprotein, transcription, or diseases, a screening may be performed by adding a compound to the polypeptide of the invention and monitoring the change of the compound. The enzymatic activity may also be utilized to screen a compound that can inhibit the activity of the polypeptide.
  • In a screening given as an example, the polypeptide of the invention is expressed and the recombinant polypeptide is purified. Then, compounds are contacted with the purified polypeptide, and the amount of the compound and the reaction products is examined. Alternatively, compounds that are candidates of an inhibitor are pretreated, then a compound (substrate) that can react with the purified polypeptide is added, and the amount of the substrate and the reaction products is examined.
  • The compounds obtained in the screening may be used as a medicine for diseases in which the polypeptide of the invention is involved. Also they can be applied for tests that examine whether the polypeptide of the invention functions normally in vivo.
  • Whether the secretory protein, membrane protein, signal transduction-related protein, glycoprotein-related protein, or transcription-related protein of the present invention is a novel protein involved in diseases or not is determined in another method than described above, by obtaining a specific antibody against the polypeptide of the invention, and examining the relationship between the expression or activity of the polypeptide and a certain disease. In an alternative way, it may be analyzed referred to the methods in “Molecular Diagnosis of Genetic Diseases” (Elles R. edit, (1996) in the series of “Method in Molecular Biology” (Humana Press).
  • Proteins involved in diseases are targets of screening as mentioned, and thus are very useful in developing drugs which regulate their expression and activity. Also, the proteins are useful in the medicinal industry as a diagnostic marker of the related disease or a target of gene therapy.
  • Compounds isolated as mentioned above can be administered patients as it is, or after formulated into a pharmaceutical composition according to the known methods. For example, a pharmaceutically acceptable carrier or vehicle, specifically sterilized water, saline, plant oil, emulsifier, or suspending agent can be mixed with the compounds appropriately. The pharmaceutical compositions can be administered to patients by a method known to those skilled in the art, such as intraarterial, intravenous, or subcutaneous injections. The dosage may vary depending on the weight or age of a patient, or the method of administration, but those skilled in the art can choose an appropriate dosage properly. If the compound is encoded by polynucleotide, the polynucleotide can be cloned into a vector for gene therapy, and used for gene therapy. The dosage of the polynucleotide and the method of its administration may vary depending on the weight or age of a patient, or the symptoms, but those skilled in the art can choose properly.
  • The present invention further relates to databases comprising at least a sequence of polynucleotide and/or polypeptide, or a medium recorded in such databases, selected from the sequence data of the nucleotide and/or the amino acids indicated in Table 1. The term “database” means a set of accumulated information as machine-searchable and readable information of nucleotide sequence. The databases of the present invention comprise at least one of the novel nucleotide sequences of polynucleotides provided by the present invention. The databases of the present invention can consist of only the sequence data of the novel polynucleotides provided by the present invention or can comprise other information on nucleotide sequences of known full-length cDNAs or ESTs. The databases of the present invention can be comprised of not only the information on the nucleotide sequences but also the information on the gene functions revealed by the present invention. Additional information such as names of DNA clones carrying the full-length cDNAs can be recorded or linked together with the sequence data in the databases.
  • The database of the present invention is useful for gaining complete gene sequence information from partial sequence information of a gene of interest. The database of the present invention comprises nucleotide sequence information of full-length cDNAs. Consequently, by comparing the information in this database with the nucleotide sequence of a partial gene fragment yielded by differential display method or subtraction method, the information on the full-length nucleotide sequence of interest can be gained from the sequence of the partial fragment as a starting clue.
  • The sequence information of the full-length cDNAs constituting the database of the present invention contains not only the information on the complete sequences but also extra information on expression frequency of the genes as well as homology of the genes to known genes and known polypeptides. Thus the extra information facilitates rapid functional analyses of partial gene fragments. Further, the information on human genes is accumulated in the database of the present invention, and therefore, the database is useful for isolating a human homologue of a gene originating from other species. The human homologue can be isolated based on the nucleotide sequence of the gene from the original species.
  • At present, information on a wide variety of gene fragments can be obtained by differential display method and subtraction method. In general, these gene fragments are utilized as tools for isolating the full-length sequences thereof. When the gene fragment corresponds to an already-known gene, the full-length sequence is easily obtained by comparing the partial sequence with the information in known databases. However, when there exists no information corresponding to the partial sequence of interest in the known databases, cDNA cloning should be carried out for the full-length cDNA. It is often difficult to obtain the full-length nucleotide sequence using the partial sequence information as an initial clue. If the full-length of the gene is not available, the amino acid sequence of the polypeptide encoded by the gene remains unidentified. Thus the database of the present invention can contribute to the identification of full-length cDNAs corresponding to gene fragments, which cannot be revealed by using databases of known genes.
  • The present invention has provided 1639 polynucleotides. As has not yet proceeded the isolation of full-length cDNA within the human, the invention has great significance. It is known that secretory proteins, membrane proteins, signal transduction-related proteins, glycoprotein-related proteins, transcription-related proteins, and so on are involved in many diseases. The genes and proteins involved in diseases are useful for developing a diagnostic marker or medicines for regulation of their expression and activity, or as a target of gene therapy.
  • In particular, cDNA assumed to encode secretory proteins, which were provided by this invention, are very important for the industry since the encoded proteins themselves are expected to be useful as pharmaceutical agents and many disease-related genes may be included in them. In addition, membrane proteins, signal transduction-related proteins, transcription-related proteins, disease-related proteins, and genes encoding them can be used as indicators for diseases, etc. These cDNA are also very important for the industry, which are expected to regulate the activity or expression of the encoded protein to treat diseases, etc.
  • Any patents, patent applications, and publications cited herein are incorporated by reference.
  • The invention is illustrated more specifically with reference to the following examples, but is not to be construed as being limited thereto.
    • EXAMPLE 1 Preparation of cDNA Library by Oligo-Capping
  • (1) Extraction and Purchase of mRNA
  • Total RNAs as mRNA sources were extracted from human tissues (shown below) by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989). Further, by the method as described in the reference (J. Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold Spring harbor Laboratory Press, 1989), total RNAs as mRNA sources were extracted from human culture cells and human primary culture cells (shown below) which had been cultivated by the methods described in the catalogs.
  • The library names and the origins are indicated below in the order of “Library name: Origin”. When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • <Extraction of mRNA from Human Tissues>
  • NTONG: Normal tongue;
  • CTONG: Tongue cancer;
  • FCBBF: Fetal brain;
  • OCBBF: Fetal brain;
  • PLACE: Placenta;
  • SYNOV: Synovial membrane tissue (from rheumatioid arthritis).
  • <Extraction of mRNA from Culture Cells>
  • BNGH4: H4 cells (ATCC #HTB-148);
  • IMR32: IMR32 cells (ATCC #CCL-127);
  • SKNMC: SK-N-MC cells (ATCC #HTB-10);
  • 3NB69: NB69 cells (RCB #RCB0480);
  • BGGI1: GI1 cells (RCB #RCB0763);
  • NB9N4: NB9 cells (RCB #RCB0477);
  • SKNSH: SK-N-SH cells (RCB #RCB0426);
  • NT2RM: NT2 cells (STARATAGENE #204101);
  • NT2RP: NT2 cells treated with retinoic acid (RA) for 5 weeks to induce the differentiation;
  • NT2RI: NT2 cells treated with RA for 5 weeks to induce the differentiation, followed by the treatment with the growth inhibitor for 2 weeks;
  • NT2NE: NT2 cells were treated with RA and the growth inhibitor for the neuronal differentiation, and the resultant neurons were concentrated and harvested (NT2 Neuron);
  • NTISM: NT2 cells (STARATAGENE #204101) were treated with RA for weeks to induce the differentiation, and then treated with the growth inhibitor for 2 weeks; mRNA was prepared from the cells and a cDNA library was constructed from the mRNA; the cDNAs of the library whose nucleotide sequences were shared by those of mRNAs from undifferentiated NT2 cells were subtracted by using a Subtract Kit (Invitrogen #K4320-01); the subtracted library (NT2RI-NT2RM) was provided by this procedure.
  • RCB indicates that the cell was provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research; ATCC indicates that the cell was provided by American Type Culture Collection.
  • <Extraction of mRNA from Primary Culture Cells>
  • ASTRO: Normal human astrocyte NHA5732, Takara Shuzo #CC2565;
  • DFNES: Normal human dermal fibroblast (neonatal skin); NHDF-Neo NHDF2564, Takara Shuzo #CC2509;
  • MESAN: Normal human mesangial cell NHMC56046-2, Takara Shuzo #CC2559;
  • NHNPC: Normal human neural progenitor cell NHNP5958, Takara Shuzo #CC2599;
  • PEBLM: Normal human peripheral blood mononuclear cell HPBMC5939, Takara Shuzo #CC2702;
  • HSYRA: Human synoviocyte HS-RA (from rheumatioid arthritis), Toyobo #T404K-05;
  • PUAEN: Normal human pulmonary artery endothelial cells, Toyobo #T302K-05;
  • UMVEN: Normal human umbilical vein endothelial cell HUVEC, Toyobo #T200K-05;
  • HCASM: Normal human coronary artery smooth muscle cell HCASMC, Toyobo #T305K-05;
  • HCHON: Normal human chondrocyte HC, Toyobo #T402K-05;
  • HHDPC: Normal human dermal papilla cell HDPC, Toyobo #THPCK-001;
  • CD34C: CD34+ cells (AllCells, LLC #CB14435M);
  • D3OST: CD34+ cells treated with the osteoclast differentiation factor (ODF) for 3 days to induce the differentiation;
  • D6OST: CD34+ cells treated with ODF for 6 days to induce the differentiation;
  • D9OST: CD34+ cells treated with ODF for 9 days to induce the differentiation.
  • Then, total RNAs extracted from the following human tissues were purchased and used as mRNA sources. The library names and the origins are indicated below in the order of “Library name: Origin”. When a library was prepared by the subtraction method, the item is followed by a description of how to prepare the subtracted library.
  • <Purchase of Total RNA Containing mRNA Extracted from Human Tissues>
  • ADRGL: Adrenal gland, CLONTECH #64016-1;
  • BRACE: Brain (cerebellum), CLONTECH #64035-1;
  • BRAWH: Whole brain, CLONTECH #64020-1;
  • FEBRA: Fetal brain, CLONTECH #64019-1;
  • FELIV: Fetal liver, CLONTECH #64018-1;
  • HEART: Heart, CLONTECH #64025-1;
  • HLUNG: Lung, CLONTECH #64023-1;
  • KIDNE: Kidney, CLONTECH #64030-1;
  • LIVER: Liver, CLONTECH #64022-1;
  • MAMGL: Mammary Gland, CLONTECH #64037-1;
  • PANCR: Pancreas, CLONTECH #64031-1;
  • PROST: Prostate, CLONTECH #64038-1;
  • SALGL: Salivary Gland, CLONTECH #64026-1;
  • SKMUS: Skeletal Muscle, CLONTECH #64033-1;
  • SMINT: Small Intestine, CLONTECH #64039-1;
  • SPLEN: Spleen, CLONTECH #64034-1;
  • STOMA: Stomach, CLONTECH #64090-1;
  • TBAES: Breast (Tumor), CLONTECH #64015-1;
  • TCERX: Cervix (Tumor), CLONTECH #64010-1;
  • TCOLN: Colon (Tumor), CLONTECH #64014-1;
  • TESTI: Testis, CLONTECH #64027-1;
  • THYMU: Thymus, CLONTECH #64028-1;
  • TLUNG: Lung (Tumor), CLONTECH #64013-1;
  • TOVAR: Ovary (Tumor), CLONTECH #64011-1;
  • TRACH: Trachea, CLONTECH #64091-1;
  • TUTER: Uterus (Tumor), CLONTECH #64008-1;
  • UTERU: Uterus, CLONTECH #64029-1;
  • ADIPS: Adipose, Invitrogen #D6005-01;
  • BLADE: Bladder, Invitrogen #D6020-01;
  • BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01;
  • CERVX: Cervix, Invitrogen #D6047-01;
  • COLON: Colon, Invitrogen #D6050-0;
  • NESOP: Esophagus, Invitrogen #D6060-01;
  • PERIC: Pericardium, Invitrogen #D6105-01;
  • RECTM: Rectum, Invitrogen #D6110-01;
  • TESOP: Esophageal (Tumor), Invitrogen #D6860-01;
  • TKIDN: Kidney (Tumor), Invitrogen #D6870-01;
  • TLIVE: Liver (Tumor), Invitrogen #D6880-01;
  • TSTOM: Stomach (Tumor), Invitrogen #D6920-01;
  • BEAST: Adult breast, STARATAGENE #735044;
  • FEHRT: Fetal heart, STARATAGENE #738012;
  • FEKID: Fetal kidney, STARATAGENE #738014;
  • FELNG: Fetal lung, STARATAGENE #738020;
  • NOVAR: Adult ovary, STARATAGENE #735260;
  • BRASW: subtracted library (BRALZ-BRAWH).
  • A cDNA library was constructed from mRNA prepared from tissues of cerebral cortex obtained from an Alzheimer patient [BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex, Alzheimer), Invitrogen #D6830-01]; the cDNAs of this library whose nucleotide sequences were shared by those of mRNAs from whole brain tissue [BRAWH: Whole brain, CLONTECH #64020-1] were subtracted by using a Subtract Kit (Invitrogen #K4320-01).
  • Further, mRNAs extracted and purified as poly A(+) RNAs from the human tissues shown below were purchased. A cDNA library was prepared from an RNA mixture in which the poly A(+) RNA from each tissue had been combined with poly A(−) RNA. The poly A(−) RNA was prepared by removing poly A(+) RNA from the total RNA of whole brain tissue (CLONTECH #64020-1) by using oligo dT cellulose. The library names and the origins are indicated below in the order of “Library name: Origin”.
  • <Purchase of mRNAs of Human Tissues as Poly A(+) RNAs>
  • BRAMY: Brain (amygdala), CLONTECH #6574-1;
  • BRCAN: Brain (caudate nucleus), CLONTECH #6575-1;
  • BRCOC: Brain (corpus callosum), CLONTECH #6577-1;
  • BRHIP: Brain (hippocampus), CLONTECH #6578-1;
  • BRSSN: Brain (substantia nigra), CLONTECH #6580-1;
  • BRSTN: Brain (subthalamic nucleus), CLONTECH #6581-1;
  • BRTHA: Brain (thalamus), CLONTECH #6582-1.
  • (2) Preparation of cDNA Library
  • cDNA library was prepared from each RNA by the improved method (WO 01/04286) of oligo capping [M. Maruyama and S. Sugano, Gene, 138: 171-174 (1994)]. A series of procedures, BAP (Bacterial Alkaline Phosphatase) treatment, TAP (Tobacco Acid Pyrophosphatase) treatment, RNA ligation, first strand cDNA synthesis and RNA removal, were carried out using the oligo-cap linker (SEQ ID NO: 3279) and oligo dT primer (SEQ ID NO: 3280), as described in WO 01/04286. Then, the single-stranded cDNA was converted to a double-stranded cDNA by PCR (polymerase chain reaction) using 5′ (SEQ ID NO: 3281) and 3′ (SEQ ID NO: 3282) PCR primers, and then digested with SfiI. Then, a fraction of cDNA fragments, typically 2-kb or longer (3-kb or longer in some cases), was unidirectionally cloned into a DraIII-digested pME18SFL3 vector (FIG. 1) (GenBank AB009864, Expression vector); the cDNA library was thus prepared.
  • The names of cDNA libraries, which were used in the analysis of full-length cDNA sequences, and their origins are shown in Table 2.
    TABLE 2
    Library Type Origin, etc.
    3NB69 Culture cell NB69 cells (RCB #RCB0480)
    ADRGL Tissue Adrenal gland (CLONTECH #64016-1)
    ASTRO Primary Normal Human Astrocyte NHA5732 (Takara Shuzo #CC2565)
    culture cell
    BGGI1 Culture cell GI1 cells (RCB #RCB0763)
    BNGH4 Culture cell H4 cells (ATCC #HTB-148)
    BRACE Tissue Brain, cerebellum (CLONTECH #64035-1)
    BRAWH Tissue Brain, whole (CLONTECH #64020-1)
    CD34C Primary CD34+ cells (AllCells, LLC #CB14435M)
    culture cell
    CTONG Tissue Tongue, Cancer
    D3OST Primary CD34+ cells (ODF induction for 3 days)
    culture cell
    DFNES Primary Normal Human Dermal Fibroblasts (Neonatal Skin); NHDF-Neo
    culture cell NHDF2564 (Takara Shuzo #CC2509)
    FCBBF Tissue Brain, Fetal
    FEBRA Tissue Brain, Fetal (CLONTECH #64019-1)
    HCASM Primary Human coronary artery smooth muscle cells HCASMC
    culture cell (Toyobo #T305K-05)
    HEART Tissue Heart (CLONTECH #64025-1)
    HHDPC Primary Human dermal papilla cells HDPC (Toyobo #THPCK-001)
    culture cell
    HLUNG Tissue Lung (CLONTECH #64023-1)
    HSYRA Primary Human synoviocytes from rheumatioid arthritis HS-RA(Toyobo
    culture cell #T404K-05)
    IMR32 Culture cell IMR32 cells (ATCC #CCL-127)
    KIDNE Tissue Kidney (CLONTECH #64030-1)
    LIVER Tissue Liver (CLONTECH #64022-1)
    MAMGL Tissue Mammary Gland (CLONTECH #64037-1)
    MESAN Primary Normal human mesangial cells NHMC56046-2 (Takara Shuzo
    culture cell #CC2559)
    NB9N4 Culture cell NB9 cells (RCB #RCB0477)
    NESOP Tissue Esophagus (Invitrogen #D6060-01)
    NHNPC Primary Normal human neural progenitor cells NHNP5958 (Takara
    culture cell Shuzo #CC2599)
    NT2NE Culture cell NT2 cells concentrated after differentiation (NT2 Neuron)
    NT2RI Culture cell NT2 cells treated by growth inhibitor for 2 weeks after RA
    induction for 5 weeks
    NT2RP Culture cell NT2 cells treated by RA for 5 weeks
    NTONG Tissue Tongue
    OCBBF Tissue Brain, Fetal
    PANCR Tissue Pancreas (CLONTECH #64031-1)
    PEBLM Primary Human peripheral blood mononuclear cells HPBMC5939
    culture cell (Takara Shuzo #CC2702)
    PLACE Tissue Placenta
    PROST Tissue Prostate (CLONTECH #64038-1)
    PUAEN Primary Human pulmonary artery endothelial cells (Toyobo #T302K-05)
    culture cell
    SALGL Tissue Salivary Gland (CLONTECH #64026-1)
    SKMUS Tissue Skeletal Muscle (CLONTECH #64033-1)
    SKNMC Culture cell SK-N-MC cells (ATCC #HTB-10)
    SKNSH Culture cell SK-N-SH cells (RCB #RCB0426)
    SMINT Tissue Small Intestine (CLONTECH #64039-1)
    SPLEN Tissue Spleen (CLONTECH #64034-1)
    STOMA Tissue Stomach (CLONTECH #64090-1)
    SYNOV Tissue Synovial membrane tissue from rheumatioid arthritis
    TESTI Tissue Testis (CLONTECH #64027-1)
    THYMU Tissue Thymus (CLONTECH #64028-1)
    TRACH Tissue Trachea (CLONTECH #64091-1)
    UMVEN Primary Human umbilical vein endothelial cells HUVEC (Toyobo
    culture cell #T200K-05)
    UTERU Tissue Uterus (CLONTECH #64029-1)
  • The cDNA library with the high fullness ratio (the fullness ratio of 5′-end, which was calculated for each cDNA library by using the protein coding region found in known mRNA species as an index, was 90% in average) prepared by the improved oligo-capping method was constructed by using a eukaryotic expression vector pME18SFL3. The vector contains SRα promoter and SV40 small t intron in the upstream of the cloning site, and SV40 polyA added signal sequence site in the downstream. As the cloning site of pME18SFL3 has asymmetrical DraIII sites, and the ends of cDNA fragments contain SfiI sites complementary to the DraIII sites, the cloned cDNA fragments can be inserted into the downstream of the SRα promoter unidirectionally. Therefore, clones containing full-length cDNA can be expressed transiently by introducing the obtained plasmid directly into COS cells, etc. Thus, the clones can be analyzed very easily in terms of the proteins that are the gene products of the clones, or in terms of the biological activities of the proteins.
  • (3) Assessment of the 5′-End Completeness of Clones Derived from the cDNA Library Prepared by Oligo-Capping
  • With respect to the plasmid DNAs of clones derived from the libraries, the nucleotide sequences of cDNA 5′-ends (3′-ends as well in some cases) were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual. A database was constructed based on the obtained data.
  • The 5′-end completeness of about 770,000 clones derived from the human cDNA libraries prepared by the improved oligo-capping method was determined by the following method. The clones whose 5′-end sequences were consistent with those of known human mRNA in the public database were judged to be “full-length” if they had a longer 5′-end sequence than that of the known human mRNA; or even though the 5′-end sequence was shorter, if it contained the translation initiation codon it was judged to have the “full-length” sequence. Clones which did not contain the translation initiation codon were judged to be “not-full-length”. The fullness ratio ((the number of full-length clones)/(the number of full-length and not-full-length clones)) at the 5′-end of the cDNA clones was determined by comparing with known human mRNA. As a result, the fullness ratio of the 5′-ends was 90%. The result indicates that the fullness ratio at the 5′-end sequence was extremely high in the human cDNA clones obtained by the oligo-capping method.
    • EXAMPLE 2 Sequencing Analysis of cDNA Ends and Selection of Full-Length Clones
  • With respect to the plasmid DNAs of clones obtained from each cDNA library, the 5′-end nucleotide sequences of the cDNAs were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems), after sequencing reaction was conducted by using a DNA sequencing reagent (Dye Terminator Cycle Sequencing FS Ready Reaction Kit, dRhodamine Terminator Cycle Sequencing FS Ready Reaction Kit or BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE Biosystems) according to the manual. A database was constructed using the data obtained.
  • For the analyzed 5′-end sequences of cDNA clones, the data with the annotation of “complete cds” in the GenBank and UniGene were searched by BLAST homology search. When identical to certain human mRNA sequences, such cDNA clones were excluded. Then, clustering was carried out. When the identity was 90% or higher, and the length of consensus sequence was 50 base pairs or longer, the cDNA clones were assumed to belong to an identical cluster, and thus clustered. cDNA clones longer in the 5′ direction were selected from the members belonging to a cluster; if required, the 3′-end sequences of the selected clones were determined by the same analysis method as used to determine the 5′-end sequences. The data of the end sequences obtained were analyzed, and then the clones forming a sequence contig at 5′- and 3′-ends were excluded. Further, as mentioned above, the data was analyzed again by BLAST homology search; when identical to certain human mRNA sequences (including sequences patented and applied for), the cDNA clones were excluded. Thus, the cDNAs clones to be analyzed for their nucleotide sequence were obtained.
    • EXAMPLE 3 Analysis of the Full-Length Nucleotide Sequences
  • The full-length nucleotide sequences of the selected clones were determined. The nucleotide sequence determination was mainly performed by primer walking method comprising the dideoxy terminator method using custom-made synthetic DNA primers. Namely, the nucleotide sequences of the DNAs were determined in a sequencer from PE Biosystems, after sequencing reaction was carried out with a DNA sequencing reagent from the same supplier using the custom-made synthetic DNA primers according to the manual. A part of the clones were analyzed with a DNA sequencer from Licor.
  • Further, the nucleotide sequences of a part of the clones were determined by the shotgun method where the plasmids containing the cDNAs were digested at random were used, instead of the use of custom-made primers, by the same method in the DNA sequencer. The full-length nucleotide sequences were finally determined by completely assembling the partial nucleotide sequences obtained by the above method.
  • Then, the regions translatable to proteins were deduced from the determined full-length nucleotide sequences, and thereby the amino acid sequences were determined. SEQ ID NOs corresponding to the respective sequences are shown in Table 1.
    • EXAMPLE 4 Functional Prediction by Homology Search
  • For the determined nucleotide sequences, GenBank, SwissProt, UniGene, and nr were searched by BLAST. The clones exhibiting higher homology, which were convenient to predict their functions based on the nucleotide sequences and deduced amino acid sequences, were selected based on the BLAST search hit data whose P value or E value was 10−4 or lower and for which the length of consensus sequence×homology=30 or higher in the amino acid database search. Further, from them, representative clones were selected, which are shown as Homology Search Result Data in the last part herein. Accordingly, the data shown herein are merely the representative data, and the molecule exhibiting homology to each clone is not limited thereto. Further, with respect to a part of clones, the BLAST search hit data that did not meet the criteria as described above are not shown herein.
    • EXAMPLE 5 Search for Signal Sequence, Transmembrane Domain and Other Functional Domains in the Deduced Amino Acid Sequences
  • With respect to the amino acid sequences deduced from the full-length nucleotide sequences, the prediction was made for the presence of signal sequence at the amino terminus, the presence of transmembrane domain, and the presence of functional protein domains (motifs). The signal sequence at the amino terminus was searched for by PSORT [K. Nakai & M. Kanehisa, Genomics, 14: 897-911 (1992)]; the transmembrane domain, by SOSUI [T. Hirokawa et al., Bioinformatics, 14: 378-379 (1998)] (Mitsui Knowledge Industry); the function domain, by Pfam (http://www.sanger.ac.uk/Software/Pfam/index.shtml). The amino acid sequence in which the signal sequence at the amino terminus or transmembrane domain had been predicted to be present by PSORT or SOSUI were assumed to be a secretory or membrane protein. Further, when the amino acid sequence hit a certain functional domain by the Pfam functional domain search, the protein function can be predicted based on the hit data, for example, by referring to the function categories on the PROSITE (http://www.expasy.ch/cgi-bin/prosite-list.pl). In addition, the functional domain search can also be carried out on the PROSITE.
  • The search results obtained with the respective programs are shown below.
  • The clones whose deduced amino acid sequences were detected to have the signal sequences by PSORT are as follows.
  • ADRGL10001600, BGGI120010970, BNGH410001180, BNGH410001370, BRACE10001690, BRACE20010650, BRACE20014920, BRACE20079530, BRACE20086550, BRACE20089600, BRAWH20004430, BRAWH20040950, BRAWH20052250, BRAWH20092610, CD34C20000510, CTONG20028160, FEBRA20003780, FEBRA20004150, FEBRA20006900, FEBRA20008090, FEBRA20012270, FEBRA20015840, FEBRA20020860, FEBRA20021910, FEBRA20037070, HHDPC20000950, HLUNG10000240, HLUNG20001250, HSYRA20003470, HSYRA20014200, IMR3210001580, IMR3220007750, IMR3220008590, KIDNE10001430, KIDNE20001670, KIDNE20003300, KIDNE20042620, KIDNE20054000, KIDNE20060530, KIDNE20066520, LIVER10005420, MAMGL10000320, NHNPC20002060, NT2NE10001630, NT2NE20016260, NT2NE20055170, NT2RI20009740, NT2RI20015400, NT2RI20030110, NT2RI20042840, NT2RI20053350, NT2RI20070840, NT2RI20073030, NT2RI20074980, NT2RI20078270, NT2RI20092890, NT2RP70015910, NT2RP70021510, NT2RP70029820, NT2RP70047900, NT2RP70074220, NT2RP70079250, NT2RP70091680, NT2RP70094290, NT2RP70094980, NT2RP70095070, NTONG10000980, NTONG10002140, NTONG10002570, OCBBF10000420, PANCR10000210, PLACE60020840, PLACE60026990, PLACE60043960, PLACE60049930, PLACE60050290, PROST10005260, PROST10005360, PROST20000360, PROST20029600, PROST20044160, PROST20054260, PROST20058800, SMINT10000160, SPLEN10000910, SPLEN20001340, STOMA20002570, TESTI20026320, TESTI20026980, TESTI20027070, TESTI20028660, TESTI20042870, TESTI20049940, THYMU10000830, UTERU10001920, UTERU20003930, UTERU20004850
  • The clones whose deduced amino acid sequences were detected to have the transmembrane domains by SOSUI are as follows. Numerals indicate the numbers of transmembrane domains detected in the deduced amino acid sequences. Of the search result, the clone name and the number of transmembrane domains are demarcated by a double slash mark (//).
  • 3NB6910000180//4, 3NB6910000850//1, 3NB6920000290//2, 3NB6920003300//5, 3NB6920005450//2, ADRGL10000180//1, ADRGL10001600//1, ADRGL20003230//2, BGGI120010970//1, BNGH410000800//2, BNGH410001040//2, BNGH410001370//1, BNGH410001980//11, BRACE20007180//1, BRACE20010650//1, BRACE20011170//2, BRACE20013400//2, BRACE20013520//2, BRACE20014230//2, BRACE20014530//1, BRACE20014920//1, BRACE20018590//1, BRACE20022270//1, BRACE20026850//1, BRACE20030780//3, BRACE20031100//10, BRACE20034490//2, BRACE20071380//3, BRACE20071970//1, BRACE20072810//2, BRACE20075020//1, BRACE20075380//3, BRACE20076410//1, BRACE20076850//1, BRACE20077610//2, BRACE20077640//2, BRACE20077980//1, BRACE20086550//1, BRACE20089600//1, BRACE20091880//1, BRAWH10000010//1, BRAWH10000370//1, BRAWH10000940//1, BRAWH10001620//1, BRAWH10001800//1, BRAWH20004430//8, BRAWH20006970//1, BRAWH20011290//4, BRAWH20014380//2, BRAWH20015030//2, BRAWH20036930//1, BRAWH20038320//2, BRAWH20059980//1, BRAWH20087060//1, BRAWH20092610//3, CD34C20000510//1, CTONG20015330//1, CTONG20028160//2, CTONG20037820//1, CTONG20047160//4, FCBBF10006180//3, FCBBF10006750//2, FCBBF20005910//1, FCBBF20009400//3, FCBBF20015380//5, FEBRA20004040//2, FEBRA20004150//3, FEBRA20004520//3, FEBRA20004910//2, FEBRA20006560//3, FEBRA20008800//1, FEBRA20010930//7, FEBRA20012450//3, FEBRA20012940//1, FEBRA20013510//2, FEBRA20014870//1, FEBRA20015840//2, FEBRA20020860//2, FEBRA20021910//1, FEBRA20031550//2, FEBRA20041910//1, FEBRA20063150//1, FEBRA20066670//2, HCASM10000610//2, HCASM20002020//1, HEART20000990//1, HEART20004920//2, HHDPC20000950//2, HLUNG10000370//2, HLUNG20001160//1, HLUNG20001420//12, HLUNG20001760//2, HSYRA20003470//1, HSYRA20008280//1, HSYRA20011030//1, HSYRA20015800//2, IMR3210000440//1, IMR3210001580//2, IMR3210002660//6, IMR3220008590//1, IMR3220009840//2, KIDNE10001040//1, KIDNE10001430//1, KIDNE20000700//1, KIDNE20000850//1, KIDNE20001670//7, KIDNE20003150//1, KIDNE20003300//7, KIDNE20003490//4, KIDNE20004220//1, KIDNE20005170//7, KIDNE20033050//2, KIDNE20033570//1, KIDNE20039410//5, KIDNE20044110//3, KIDNE20048280//12, KIDNE20049810//2, KIDNE20054770//12, KIDNE20060530//2, KIDNE20060620//2, KIDNE20063530//1, KIDNE20066520//2, KIDNE20067600//1, KIDNE20071860//1, KIDNE20074220//1, KIDNE20075690//5, LIVER10000580//3, LIVER10000670//1, LIVER10001040//2, LIVER10001110//1, LIVER10001750//1, LIVER20004160//1, MAMGL10001780//1, MAMGL10001840//2, MESAN10001470//1, MESAN10001800//7, MESAN20001490//2, NB9N420000420//1, NHNPC20002060//2, NT2NE10000230//1, NT2NE10001850//6, NT2NE20003920//1, NT2NE20004550//1, NT2NE20004700//1, NT2NE20005500//1, NT2NE20012470//2, NT2NE20014350//1, NT2NE20016260//4, NT2NE20034080//2, NT2NE20047160//1, NT2NE20055170//3, NT2NE20057200//1, NT2RI20005970//7, NT2RI20014490//11, NT2RI20016570//2, NT2RI20018460//1, NT2RI20018660//2, NT2RI20021520//7, NT2RI20022430//4, NT2RI20022520//3, NT2RI20030110//1, NT2RI20030510//2, NT2RI20033830//2, NT2RI20036780//1, NT2RI20044420//1, NT2RI20049850//2, NT2RI20050870//8, NT2RI20051500//1, NT2RI20066820//1, NT2RI20068250//11, NT2RI20070480//1, NT2RI20077540//4, NT2RI20078790//1, NT2RI20081880//3, NT2RI20085980//3, NT2RI20092890//2, NT2RI20094060//4, NT2RP60000320//10, NT2RP60000390//1, NT2RP60001090//1, NT2RP70002380//4, NT2RP70002590//5, NT2RP70003640//1, NT2RP70004770//4, NT2RP70006240//1, NT2RP70011660//11, NT2RP70015910//2, NT2RP70021510//1, NT2RP70023790//2, NT2RP70026190//1, NT2RP70043730//3, NT2RP70047900//2, NT2RP70049250//1, NT2RP70064080//3, NT2RP70071540//2, NT2RP70071770//13, NT2RP70072520//2, NT2RP70073810//3, NT2RP70075040//4, NT2RP70076170//2, NT2RP70079750//2, NT2RP70081330//2, NT2RP70081370//8, NT2RP70085500//2, NT2RP70090120//10, NT2RP70091490//3, NT2RP70093220//11, NT2RP70093730//1, NT2RP70094290//1, NT2RP70094810//12, NT2RP70094980//3, NTONG10002570//2, NTONG20002650//4, NTONG20004920//1, NTONG20008000//1, NTONG20012220//1, OCBBF20002310//2, OCBBF20009980//1, OCBBF20012100//2, PLACE50000670//1, PLACE50001050//1, PLACE60005550//2, PLACE60012810//2, PLACE60018860//7, PLACE60020160//1, PLACE60020840//6, PLACE60037050//1, PLACE60037450//1, PLACE60047380//1, PLACE60049930//1, PLACE60050290//1, PROST10002200//2, PROST10002720//1, PROST10005360//1, PROST20000360//1, PROST20001760//4, PROST20029600//2, PROST20033020//1, PROST20039220//3, PROST20044160//1, PROST20051430//1, PROST20054260//5, PROST20059190//3, PROST20059430//3, PROST20069880//1, PROST20072370//1, PUAEN10000570//1, PUAEN10001610//1, PUAEN10003220//1, SKMUS20007740//1, SKNMC10000190//1, SKNMC10000290//1, SKNMC10002290//2, SKNMC10002510//8, SMINT10000160//2, SMINT10000420//8, SMINT10000570//2, SMINT10001180//1, SMINT20000180//2, SMINT20002770//3, SPLEN20001340//1, SPLEN20002430//1, SPLEN20002700//1, SPLEN20003100//1, SPLEN20004960//2, STOMA10000520//2, STOMA10001170//1, STOMA20000320//1, STOMA20002570//3, SYNOV20001770//2, TESTI10000420//1, TESTI10000960//1, TESTI20006000//1, TESTI20009090//1, TESTI20009700//7, TESTI20011340//5, TESTI20012370//1, TESTI20013520//4, TESTI20014200//9, TESTI20016210//2, TESTI20016710//1, TESTI20018620//2, TESTI20020020//2, TESTI20020810//8, TESTI20022510//3, TESTI20024670//2, TESTI20025800//2, TESTI20026980//2, TESTI20027000//1, TESTI20030370//1, TESTI20031930//1, TESTI20042870//3, TESTI20047120//5, TESTI20049940//2, TESTI20057420//1, TESTI20058600//6, TESTI20067740//2, TESTI20069780//3, TESTI20074800//5, TESTI20077490//4, TESTI20079510//3, TESTI20080200//7, TESTI20081440//1, TESTI20087740//2, TESTI20088470//2, TESTI20136910//1, THYMU10001760//1, THYMU10003290//1, THYMU10003820//4, THYMU10005580//4, TRACH10000630//3, TRACH10001000//1, TRACH10001400//1, TRACH20001850//2, TRACH20001960//2, TRACH20004960//2, TRACH20006650//11, TRACH20007670//2, TRACH20008980//2, TRACH20015920//2, UMVEN20001330//2, UTERU10000770//2
  • The Names of clones whose deduced amino acid sequences were detected to have functional domains with Pfam, and the name of hit functional domains are as follows. The search result is indicated as “clone name//functional domain name”. When the clone has multiple hit functional domains, they are listed and demarcated by a double slash mark (//). When the clone has multiple hits of an identical functional domain, each is listed without abridgment.
  • 3NB6910000180//TS-N domain//UBA domain
  • 3NB6910001160//START domain
  • 3NB6910001290//KRAB box
  • 3NB6910001730//RI01/ZK632.3/MJ0444 family
  • 3NB6920002810//DEAD/DEAH box helicase//Helicases conserved C-terminal domain
  • 3NB6920009120//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Frataxin-like domain
  • 3NB6920010020//Regulator of G protein signaling domain
  • 3NB6920014330//Domain of unknown function
  • 3NB6920014710//DNA binding domain with preference for A/T rich regions//Zinc finger, C2H2 type
  • 3NB6920015110//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • 3NB6920015570//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • ADRGL10000020//BTB/POZ domain//Kelch motif//Kelch motif
  • ADRGL10000650//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • ADRGL10001600//Cytochrome P450//Cytochrome P450
  • ADRGL10001650//Urease//Chlorohydrolase//Dihydroorotase-like
  • ADRGL20000740//Dockerin domain type I//RhoGAP domain
  • ASTRO10000180//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • ASTRO20000950//SNAP-25 family
  • ASTRO20004170//Ribonuclease T2 family
  • BGGI120005330//IMP dehydrogenase/GMP reductase N terminus//CBS domain//CBS domain//Dihydroorotate dehydrogenase//Histidine biosynthesis protein//FMN-dependent dehydrogenase//Conserved region in glutamate synthase//IMP dehydrogenase/GMP reductase C terminus
  • BGGI120005440//Importin beta binding domain
  • BGGI120006840//Sir2 family
  • BGGI120006930//Collagen triple helix repeat (20 copies)//SAM domain (Sterile alpha motif)
  • BGGI120010970//F5/8 type C domain//Laminin G domain//Laminin G domain//Fibrinogen beta and gamma chains, C-terminal globular domain
  • BGGI120017140//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • BNGH410000290//SPRY domain
  • BNGH410000340//Prolyl oligopeptidase family//Phospholipase/Carboxylesterase
  • BNGH410001040//Eukaryotic protein kinase domain
  • BNGH410001180//Low-density lipoprotein receptor domain class A//Low-density lipoprotein receptor domain class A//Low-density lipoprotein receptor domain class A//WAP-type (Whey Acidic Protein) ‘four-disulfide core’//Low-density lipoprotein receptor domain class A//Low-density lipoprotein receptor domain class A//Low-density lipoprotein receptor domain class A//Low-density lipoprotein receptor domain class A//long chain scorpion toxins//Chitin binding Peritrophin-A domain//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B//Low-density lipoprotein receptor repeat class B
  • BNGH410001370//Filamin/ABP280 repeat.
  • BNGH410001770//IMP dehydrogenase/GMP reductase N terminus//CBS domain//CBS domain//Dihydroorotate dehydrogenase//Histidine biosynthesis protein//FMN-dependent dehydrogenase//Conserved region in glutamate synthase//IMP dehydrogenase/GMP reductase C terminus
  • BNGH410001900//Viral (Superfamily 1) RNA helicase
  • BNGH410001980//POT family//Bacteriorhodopsin//Sugar (and other) transporter
  • BNGH420005320//SCAN domain//KRAB box//Zinc finger, C2H2 type//GATA zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type
  • BRACE10000420//Fatty acid desaturase//Protein phosphatase 2C
  • BRACE10000930//Zinc finger, C3HC4 type (RING finger)//TRAF-type zinc finger//TRAF-type zinc finger//MATH domain
  • BRACE10001150//DNA gyrase/topoisomerase IV, subunit A//Nucleosome assembly protein (NAP)
  • BRACE10001660//Zinc finger, C2H2 type
  • BRACE20002800//IQ calmodulin-binding motif
  • BRACE20005650//ATP synthase ab C terminal
  • BRACE20006980//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
  • BRACE20007180//Calcitonin/CGRP/IAPP family
  • BRACE20008850//Zinc finger, C3HC4 type (RING finger)
  • BRACE20010650//F-box domain.
  • BRACE20013750//Hepatitis C virus non-structural protein NS4a
  • BRACE20014920//Protein-tyrosine phosphatase
  • BRACE20018550//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
  • BRACE20018590//Transmembrane 4 family
  • BRACE20019440//Protein of unknown function DUF82
  • BRACE20020910//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//E7 protein, Early protein//B-box zinc finger.
  • BRACE20022020//Eukaryotic protein kinase domain
  • BRACE20024090//Homeobox domain
  • BRACE20024680//Similarity to lectin domain of ricin beta-chain, 3 copies.
  • BRACE20026850//short chain dehydrogenase
  • BRACE20027720//Metallo-beta-lactamase superfamily
  • BRACE20027920//FGGY family of carbohydrate kinases
  • BRACE20028120//Ras family//ADP-ribosylation factor family
  • BRACE20031100//Domain of unknown function DUF20//Patched family
  • BRACE20071740//KRAB box//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • BRACE20074010//EF hand//EF hand//Mitochondrial carrier proteins//Mitochondrial carrier proteins//Mitochondrial carrier proteins
  • BRACE20074470//Cadherin domain//Cadherin domain//Glutathione peroxidases//Cadherin domain
  • BRACE20076410//Sushi domain (SCR repeat)//Sushi domain (SCR repeat)//Sushi domain (SCR repeat)
  • BRACE20076630//PH domain
  • BRACE20080970//Phosphofructokinase
  • BRACE20083800//Fibronectin type III domain
  • BRACE20083850//bZIP transcription factor//Homeobox associated leucine zipper
  • BRACE20084430//Thioredoxin//Thioredoxin
  • BRACE20092120//3′-5′ exonuclease//Adenylylsulfate kinase//Protein of unknown function DUF82
  • BRACE20093610//Bacterial type II secretion system protein
  • BRAWH10000940//Rieske [2Fe-2S] domain//Phosphoglucose isomerase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Phytoene dehydrogenase related enzyme
  • BRAWH10001300//PH domainH/RhoGAP domain//Tropomyosins
  • BRAWH10001620//alpha/beta hydrolase fold
  • BRAWH10001640//KRAB box//ENV polyprotein (coat polyprotein)
  • BRAWH10001680//Homeobox domain
  • BRAWH20000480//Transposase//Kinesin motor domain
  • BRAWH20001770//Serine hydroxymethyltransferase
  • BRAWH20003230//Wiskott Aldrich syndrome homology region 2
  • BRAWH20004430//Lectin (probable mannose binding)//Surfactant associated polypeptide
  • BRAWH20004760//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • BRAWH20006330//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • BRAWH20006510//HMGL-like
  • BRAWH20006860//Eukaryotic protein kinase domain//Protein kinase C terminal domain
  • BRAWH20009840//Cytochrome P450
  • BRAWH20011660//Glycosyl hydrolases family 35
  • BRAWH20012030//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C3HC4 type (RING finger)//PHD-finger
  • BRAWH20014180//Adenosine-deaminase (editase) domain
  • BRAWH20014610//TS-N domain//UBA domain
  • BRAWH20014840//Glycosyl transferases//Similarity to lectin domain of ricin beta-chain, 3 copies.
  • BRAWH20036890//Protein phosphatase 2C
  • BRAWH20059980//CUB domain//Low-density lipoprotein receptor domain class A//CUB domain//Low-density lipoprotein receptor domain class A//Fz domain
  • BRAWH20060440//PPR repeat
  • BRAWH20064500//Nuclear transition protein 2//HMG (high mobility group) box
  • BRAWH20076050//Keratin, high sulfur B2 protein
  • BRAWH20089560//Poly-adenylate binding protein, unique domain.//Magnesium chelatase, subunit ChII//Uncharacterized protein family UPF0034//KE2 family protein//Formin Homology 2 Domain
  • BRAWH20093600//Family 4 glycosyl hydrolase
  • CD34C20000510//Glycosyl hydrolases family 18//Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain
  • CTONG20005890//DNA gyrase/topoisomerase IV, subunit A//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).
  • CTONG20011390//Prokaryotic dksA/traR C4-type zinc finger//Hepatitis C virus non-structural protein NS2
  • CTONG20013200//Uncharacterized protein family UPF0020
  • CTONG20018200//PHD-finger//PHD-finger//PWWP domain//SET domain
  • CTONG20019550//Spectrin repeat//Xylose isomerase//Spectrin repeat//Spectrin repeat//Spectrin repeat//Flagellar hook-associated protein 2//Adhesin lipoprotein//Spectrin repeat//Spectrin repeat//Protein of unknown function DUF118//Spectrin repeat//Bacterial flagellin N-terminus//Spectrin repeat//Spectrin repeat//Spectrin repeat//Caulimovirus movement protein//Spectrin repeat
  • CTONG20025580//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • CTONG20028030//Domain of unknown function DUF19//Ribosomal protein S18
  • CTONG20028160//Cadherin domain//Cadherin domain//Cadherin domain//Cadherin domain//Cadherin cytoplasmic region
  • CTONG20028200//Papain family cysteine protease//E2 (early) protein, N terminal//T-box
  • CTONG20037820//Neurotransmitter-gated ion-channel//Neurotransmitter-gated ion-channel
  • CTONG20047160//PCI domain//Latrophilin/CL-1-like GPS domain
  • CTONG20055530//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Pyridoxal-dependent decarboxylase conserved domain//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
  • CTONG20064490//PCI domain D30ST20001840//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • DFNES20002120//Queuine tRNA-ribosyltransferase
  • DFNES20002680//Protozoan/cyanobacterial globin//KE2 family protein//Adhesin lipoprotein
  • FCBBF10005980//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FCBBF10006870//Corticotropin-releasing factor family
  • FCBBF20000940//Homeobox domain
  • FCBBF20002320//T-box
  • FCBBF20002760//Kelch motif//Kelch motif//Kelch motif
  • FCBBF20005910//Adenylate kinase//Viral (Superfamily 1) RNA helicase//TPR Domain//TPR Domain
  • FCBBF20008150//LIM domain containing proteins//LIM domain containing proteins//LIM domain containing proteins
  • FCBBF20009510//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FCBBF20012110//Myc amino-terminal region
  • FCBBF20015380//GNS1/SUR4 family
  • FCBBF20016720//Domain of unknown function DUF94
  • FCBBF40002820//Electron transfer flavoprotein beta subunit
  • FCBBF50002610//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20000530//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
  • FEBRA20001050//TPR Domain//TPR Domain//TPR Domain//TPR Domain//PPR repeat//TPR Domain
  • FEBRA20003770//Ank repeat//Iron/manganese superoxide dismutases (SODM)//Ras association (RaIGDS/AF-6) domain//FERM domain (Band 4.1 family)
  • FEBRA20003970//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type
  • FEBRA20003990//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20004150//STAS domain
  • FEBRA20004540//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20005360//Cystatin domain
  • FEBRA20007330//EF hand//EF hand
  • FEBRA20007870//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20008560//Importin beta binding domain//Armadillo/beta-catenin-like repeats
  • FEBRA20008810//Actin
  • FEBRA20009720//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20011330//Trypsin and protease inhibitors//PCI domain
  • FEBRA20011460//SCAN domain
  • FEBRA20012450//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain//Immunoglobulin domain//Fibronectin type III domain
  • FEBRA20014920//S-adenosylmethionine synthetase
  • FEBRA20015840//EGF-like domain//EGF-like domain//EGF-like domain//EGF-like domain//EB module//EGF-like domain//EGF-like domain
  • FEBRA20017060//Immunoglobulin domain
  • FEBRA20017150//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//Insulin-like growth factor binding proteins//B-box zinc finger.//CONSTANS family zinc finger//B-box zinc finger.//Putative zinc finger in N-recognin//Fibronectin type III domain//SPRY domain
  • FEBRA20019890//PH domain//Putative GTP-ase activating protein for Arf//Ank repeat//Ank repeat
  • FEBRA20024290//RNA polymerase alpha subunit
  • FEBRA20024420//GMC oxidoreductases
  • FEBRA20025250//TBC domain
  • FEBRA20034290//CAP-Gly domain
  • FEBRA20043250//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Homeobox associated leucine zipper
  • FEBRA20043290//Myosin tail//lactate/malate dehydrogenase//Troponin//Domain present in Hsp70 regulators//Interleukin-6/G-CSF/MGF family//Myosin tail
  • FEBRA20044900//Pou domain—N-terminal to homeobox domain//Spectrin repeat//Spectrin repeat
  • FEBRA20045920//Glycoprotease family
  • FEBRA20050140//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20050790//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain
  • FEBRA20057260//TBC domain
  • FEBRA20057880//PDZ domain (Also known as DHR or GLGF).
  • FEBRA20060920//DIX domain
  • FEBRA20062700//haloacid dehalogenase-like hydrolase
  • FEBRA20064760//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//GATA zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20066670//Transthyretin precursor (formerly prealbumin)
  • FEBRA20067360//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20069420//KRAB box//Zinc finger, C2H2 type//Ribosomal protein L37e//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • FEBRA20070170//PX domain
  • FEBRA20072000//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
  • FEBRA20075510//Ras family
  • HCASM20002140//Cyclin
  • HCASM20003070//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • HEART20004110//POT family
  • HEART20005060//Occludin/ELL family//K-box region
  • HEART20005680//Nerve growth factor family
  • HHDPC20000550//Viral (Superfamily 1) RNA helicase//NB-ARC domain//Adenylate kinase//Adenylate kinase
  • HHDPC20000950//Extracellular link domain//Lectin C-type domain
  • HHDPC20001150//Collagen triple helix repeat (20 copies)//C1q domain
  • HHDPC20001490//UBA domain//Integrase Zinc binding domain//IBR domain//IBR domain
  • HHDPC20003150//Zn-finger in Ran binding protein and others.//Zinc knuckle
  • HHDPC20004550//FERM domain (Band 4.1 family)
  • HHDPC20004560//2S seed storage family
  • HHDPC20004620//FAD binding domain
  • HLUNG10000240//Transforming growth factor beta like domain
  • HLUNG10000370//TPR Domain//TPR Domain//TPR Domain//TPR Domain
  • HLUNG10000760//HMG (high mobility group) box
  • HLUNG10000990//Adenosylmethionine decarboxylase
  • HLUNG20000680//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • HLUNG20001420//REV protein (anti-repression trans-activator protein)//Bacteriorhodopsin//Photosystem II reaction centre T protein//Sugar (and other) transporter//FecCD transport family
  • HLUNG20001760//Transthyretin precursor (formerly prealbumin)
  • HLUNG20002550//Trypsin
  • HSYRA10001190//TBC domain
  • HSYRA10001370//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • HSYRA10001680//DEAD/DEAH box helicase
  • HSYRA10001780//Alpha-2-macroglobulin family N-terminal region
  • HSYRA20001350//F-box domain.//Kelch motif//Kelch motif//Kelch motif
  • HSYRA20005100//UvrD/REP helicase
  • HSYRA20013320//Insulin-like growth factor binding proteins//Thyroglobulin type-1 repeat
  • HSYRA20014760//von Willebrand factor type A domain
  • HSYRA20015740//Glucosamine-6-phosphate isomerase
  • HSYRA20016210//HesB-like domain
  • HSYRA20016310//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type
  • IMR3210000440//ATP1G1/PLM/MAT8 family//Eukaryotic protein kinase domain
  • IMR3210001580//Extracellular link domain//Lectin C-type domain
  • IMR3210002420//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • IMR3210002660//Cation efflux family
  • IMR3220002230//FHA domain//HIT family
  • IMR3220003020//Src homology domain 2
  • IMR3220007420//Zinc finger, C2H2 type
  • IMR3220007750//Nerve growth factor family//Kazal-type serine protease inhibitor domain//Thyroglobulin type-1 repeat//EF hand//Immunoglobulin domain//Immunoglobulin domain
  • IMR3220008380//Formyl transferase
  • IMR3220009190//Influenza Matrix protein (M1)//metallopeptidase family M24
  • IMR3220009730//Kinesin motor domain
  • IMR3220012180//tRNA pseudouridine synthase
  • IMR3220013170//Dual specificity phosphatase, catalytic domain
  • KIDNE10001040//Myb-like DNA-binding domain//Apolipoprotein A1/A4/E family//Thymidylate kinase//SNAP-25 family//Syntaxin
  • KIDNE20000410//Aminotransferases class-II pyridoxal-phosphate
  • KIDNE20000510//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • KIDNE20001670//Sugar (and other) transporter
  • KIDNE20003150//Major intrinsic protein
  • KIDNE20003300//DnaJ domain
  • KIDNE20003490//Ubiquitin family//Viral matrix protein//Src homology domain 2//Acyltransferase
  • KIDNE20003750//C2 domain
  • KIDNE20004030//RNA helicase
  • KIDNE20004970//Kinesin motor domain//K-box region
  • KIDNE20005130//Aminotransferases class-III pyridoxal-phosphate//Aminotransferases class-III pyridoxal-phosphate
  • KIDNE20005170//Uncharacterized membrane protein family UPF0013
  • KIDNE20031850//Ras association (RalGDS/AF-6) domain
  • KIDNE20033050//Amidase//Amidase
  • KIDNE20033730//SH3 domain//RhoGEF domain//PH domain
  • KIDNE20039940//DNA gyrase/topoisomerase IV, subunit A//SCAN domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • KIDNE20040840//Eukaryotic protein kinase domain//Phosphoribulokinase//Myosin head (motor domain)//Myosin head (motor domain)
  • KIDNE20043440//Ribosomal protein L36
  • KIDNE20044110//Viral methyltransferase//V-type ATPase 116 kDa subunit family
  • KIDNE20046810//Dienelactone hydrolase family
  • KIDNE20048280//Amino acid permease//Sodium:neurotransmitter symporter family
  • KIDNE20050420//Herpesvirus UL25 family//Beige/BEACH domain//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//AN1-like Zinc finger//FYVE zinc finger
  • KIDNE20052960//Actin
  • KIDNE20054770//Transmembrane amino acid transporter protein//Ion transport protein//Amino acid permease
  • KIDNE20056290//Acetyltransferase (GNAT) family
  • KIDNE20056760//Calponin homology (CH) domain
  • KIDNE20059080//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats
  • KIDNE20060140//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • KIDNE20060300//MutT-like domain
  • KIDNE20060530//Glycosyl transferase family 8
  • KIDNE20061490//SPRY domain
  • KIDNE20062480//Scorpion short toxins
  • KIDNE20062990//PH domain
  • KIDNE20066520//Bacterial extracellular solute-binding proteins, family 5
  • KIDNE20067600//Immunoglobulin domain//Immunoglobulin domain
  • KIDNE20073520//WW domain
  • KIDNE20075690//PMP-22/EMP/MP20/Claudin family
  • KIDNE20078100//Ribosomal protein L15//Integrase core domain//dUTPase
  • KIDNE20078110//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type
  • LIVER10000670//Urocanase
  • LIVER10001040//AMP-binding enzyme
  • LIVER10002300//Respiratory-chain NADH dehydrogenase 51 Kd subunit
  • LIVER10004330//Cyclic nucleotide-binding domain//Glutathione S-transferases.//Uncharacterized protein family UPF0028
  • LIVER10005420//Bowman-Birk serine protease inhibitor family
  • LIVER20000330//Peptidase family M1//K+ channel tetramerisation domain
  • LIVER20000370//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
  • MAMGL10000560//K-box region MAMGL10001780//Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit.
  • MAMGL10001820//DIX domain
  • MESAN10000350//Neurohypophysial hormones, C-terminal Domain
  • MESAN10001800//Sterol O-acyltransferase
  • MESAN20000920//SAM domain (Sterile alpha motif)//PDZ domain (Also known as DHR or GLGF).//Phosphatidylinositol 3- and 4-kinases
  • MESAN20005010//PWWP domain
  • NB9N410000470//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • NB9N410001350//lactate/malate dehydrogenase//Ras family
  • NB9N420001040//Na+/K+ ATPase C-terminus
  • NHNPC10000840//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • NHNPC20002060//DnaJ domain
  • NHNPC20002120//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2NE10000140//Zinc knuckle//Nucleotidyltransferase domain//Zinc knuckle
  • NT2NE10000730//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
  • NT2NE10000830//7 transmembrane receptor (rhodopsin family)
  • NT2NE10001850//Divalent cation transporter//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
  • NT2NE20001740//RNA pseudouridylate synthase
  • NT2NE20002140//Rhodanese-like domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain
  • NT2NE20002590//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type
  • NT2NE20003690//Carbamoyl-phosphate synthase (CPSase)
  • NT2NE20003840//TPR Domain//TPR Domain//TPR Domain
  • NT2NE20005360//Ribosomal protein S2
  • NT2NE20005500//Retroviral aspartyl protease//Retroviral aspartyl protease
  • NT2NE20006580//Zinc finger, C3HC4 type (RING finger)//ICE-like protease (caspase) p10 domain//SPRY domain
  • NT2NE20007630//Matrix protein (MA), p15
  • NT2NE20008090//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2NE20013370//SPRY domain
  • NT2NE20013720//Tryptophan synthase alpha chain//Ribulose-phosphate 3 epimerase family//Indole-3-glycerol phosphate synthases
  • NT2NE20016260//7 transmembrane receptor (rhodopsin family)
  • NT2NE20016660//DEAD/DEAH box helicase
  • NT2NE20034080//EGF-like domain//Laminin EGF-like (Domains III and V)
  • NT2NE20047160//Glycosyl transferase family 8
  • NT2NE20053710//Ank repeat
  • NT2NE20057200//Ubiquitin-conjugating enzyme//DNA mismatch repair proteins, mutS family
  • NT2RI10000270//Zinc finger C-x8-C-x5-C-x3-H type (and similar).
  • NT2RI10000480//Dual specificity phosphatase, catalytic domain
  • NT2RI20003410//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type
  • NT2RI20004120//ENTH domain//DNA polymerase (viral) C-terminal domain
  • NT2RI20004210//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20006690//Plant thionins
  • NT2RI20006850//Collagen triple helix repeat (20 copies)//Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  • NT2RI20010100//Carboxylesterases//Carboxylesterases
  • NT2RI20010830//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20014090//ROK family//Spectrin repeat//Tropomyosins//Spectrin repeat//Spectrin repeat
  • NT2RI20014500//Xylose isomerase
  • NT2RI20015400//TPR Domain
  • NT2RI20015950//Keratin, high sulfur B2 protein
  • NT2RI20016210//Bacterial regulatory proteins, luxR family
  • NT2RI20016570//DnaJ central domain (4 repeats)
  • NT2RI20018460//Glutamine synthetase//Notch (DSL) domain//Notch (DSL) domain
  • NT2RI20018660//Immunoglobulin domain//SPRY domain
  • NT2RI20020220//Phosphatidylinositol-specific phospholipase C, X domain
  • NT2RI20025170//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).
  • NT2RI20025300//Ubiquitin family
  • NT2RI20025410//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zn-finger in ubiquitin-hydrolases and other proteins//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20025540//TPR Domain//TPR Domain//TPR Domain
  • NT2RI20025850//jmjN domain//jmjC domain
  • NT2RI20029580//C2 domain//C2 domain
  • NT2RI20029700//EF hand//EF hand
  • NT2RI20030110//Immunoglobulin domain
  • NT2RI20031540//Interleukin-6/G-CSF/MGF family
  • NT2RI20032050//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats
  • NT2RI20033440//PDZ domain (Also known as DHR or GLGF).
  • NT2RI20036780//Subtilase family//Proprotein convertase P-domain
  • NT2RI20036950//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Insulin/IGF/Relaxin family//Ribosomal RNA adenine dimethylases//SAM domain (Sterile alpha motif)//TFIIE alpha subunit//Zinc finger, C3HC4 type (RING finger)
  • NT2RI20037510//Formamidopyrimidine-DNA glycosylase
  • NT2RI20046060//K+ channel tetramerisation domain
  • NT2RI20049850//Domain of unknown function
  • NT2RI20050610//Peptidase family M1
  • NT2RI20050870//Voltage gated chloride channels//Xanthine/uracil permeases family//Sulfate transporter family//STAS domain
  • NT2RI20051500//Sialyltransferase family//Photosynthetic reaction center protein
  • NT2RI20053680//Zinc finger, C2H2 type
  • NT2RI20055640//Glutathione S-transferases.//Protein of unknown function DUF61//Glutathione S-transferases.
  • NT2RI20056470//bZIP transcription factor//Transposase//bZIP transcription factor//Outer membrane efflux protein//Intermediate filament proteins
  • NT2RI20058110//Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif//RasGEF domain
  • NT2RI20060710//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20062100//Src homology domain 2
  • NT2RI20064120//Ras family//Cell division protein
  • NT2RI20066790//Immunoglobulin domain
  • NT2RI20067030//L1 (late) protein
  • NT2RI20067350//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20068250//Dolichyl-phosphate-mannose-protein mannosyltransferase//S-adenosylmethionine synthetase
  • NT2RI20068550//Helicases conserved C-terminal domain
  • NT2RI20070480//Atrial natriuretic peptide
  • NT2RI20070840//Immunoglobulin domain
  • NT2RI20070960//Hydroxymethylglutaryl-coenzyme A reductase//RhoGEF domain//Hpt domain//PH domain
  • NT2RI20071330//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20071480//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • NT2RI20072540//Ribosomal RNA adenine dimethylases//SAM domain (Sterile alpha motif)//TFIIE alpha subunit//Zinc finger, C3HC4 type (RING finger)
  • NT2RI20073840//Eukaryotic protein kinase domain
  • NT2RI20074390//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20074690//Ubiquinol-cytochrome C reductase complex 14 kD subunit
  • NT2RI20074980//Fz domain//Zinc carboxypeptidase//Zinc carboxypeptidase
  • NT2RI20078270//Acyl-CoA oxidase
  • NT2RI20078840//Homeobox domain//Bacterial regulatory proteins, crp family//Site-specific recombinases//Bacterial regulatory proteins, luxR family
  • NT2RI20078910//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • NT2RI20080500//Immunoglobul in domain//Immunoglobul in domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
  • NT2RI20083360//bZIP transcription factor
  • NT2RI20084810//Acyltransferase
  • NT2RI20085980//Bacterial regulatory proteins, crp family//CUB domain//F5/8 type C domain
  • NT2RI20087140//SET domain
  • NT2RI20088120//Bindin//HupF/HypC family
  • NT2RI20089420//Immunoglobulin domain//PKD domain
  • NT2RI20090650//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RI20091440//SPRY domain
  • NT2RI20092150//SCAN domain//Integrase core domain
  • NT2RI20092890//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain//Immunoglobulin domain
  • NT2RI20094060//DHHC zinc finger domain
  • NT2RP60000320//Cytochrome c oxidase subunit III//7 transmembrane receptor (Secretin family)//Domain found in Dishevelled, Egl-10, and Pleckstrin
  • NT2RP60000720//Molluscan rhodopsin C-terminal tail
  • NT2RP60000860//Ubiquitin-conjugating enzyme
  • NT2RP60001000//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP60001090//BTB/POZ domain//HMG (high mobility group) box//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
  • NT2RP60001230//TPR Domain//TPR Domain//TPR Domain//TPR Domain//PPR repeat//TPR Domain
  • NT2RP60001270//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70000690//Methyl-CpG binding domain
  • NT2RP70002380//Bacterial export proteins, family 3
  • NT2RP70002710//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70004770//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
  • NT2RP70006240//Integrins, beta chain//RhoGEF domain//PH domain//MORN motif//MORN motif//MORN motif//MORN motif//MORN motif//Coproporphyrinogen III oxidase//MORN motif
  • NT2RP70010800//ZAP domain
  • NT2RP70011660//Iron/manganese superoxide dismutases (SODM)//E1-E2 ATPase//Domain of unknown function DUF19//Photosystem II reaction centre T protein
  • NT2RP70012310//Alphavirus E3 glycoprotein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • NT2RP70015910//Kringle domain//WSC domain//CUB domain
  • NT2RP70018560//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
  • NT2RP70023760//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//TBC domain
  • NT2RP70024500//Picornavirus coat protein (VP4)//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//IBR domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70028750//Ank repeat//Ank repeat//Ank repeat//CAP-Gly domain
  • NT2RP70029060//Oxysterol-binding protein//Hsp90 protein
  • NT2RP70030550//PHD-finger
  • NT2RP70032030//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//GATA zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70033040//Rhodanese-like domain//Integrase Zinc binding domain//Integrase Zinc binding domain//DnaJ central domain (4 repeats)
  • NT2RP70036290//Glypican//Leucine Rich Repeat//Leucine Rich Repeat
  • NT2RP70036470//Porphobilinogen deaminase//GHMP kinases putative ATP-binding proteins
  • NT2RP70036800//Methanol dehydrogenase beta subunit//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
  • NT2RP70039600//Calpain inhibitor repeat
  • NT2RP70042040//PHD-finger//FYVE zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70042330//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
  • NT2RP70043960//SH3 domain//SH3 domain//SH3 domain//SH3 domain//SH3 domain
  • NT2RP70045410//Helix-loop-helix DNA-binding domain
  • NT2RP70046560//PHD-finger//PHD-finger
  • NT2RP70046870//Macrophage migration inhibitory factor (MIF)//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//Arenavirus glycoprotein//WD domain, G-beta repeat
  • NT2RP70049150//PWWP domain
  • NT2RP70049250//WH1 domain
  • NT2RP70055020//Sigma-54 interaction domain//ATPases associated with various cellular activities (AAA)
  • NT2RP70055130//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type
  • NT2RP70061620//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70061880//GTPase-activator protein for Ras-like GTPase
  • NT2RP70062960//SNF2 and others N-terminal domain//SNF2 and others N-terminal domain//Leishmanolysin//Helicases conserved C-terminal domain
  • NT2RP70063040//Plant PEC family metallothionein//Cell division protein
  • NT2RP70064900//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type
  • NT2RP70065270//LIM domain containing proteins//LIM domain containing proteins//LIM domain containing proteins//Helper component proteinase
  • NT2RP70069860//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type
  • NT2RP70071770//STAT protein//Zinc finger, C3HC4 type (RING finger)
  • NT2RP70072210//Viral (Superfamily 1) RNA helicase
  • NT2RP70072520//PAS domain//PAS domain//PAS domain//Eukaryotic protein kinase domain
  • NT2RP70074060//Glutamine synthetase
  • NT2RP70075370//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger.//CONSTANS family zinc finger//Putative zinc finger in N-recognin//SPRY domain
  • NT2RP70076100//SAM domain (Sterile alpha motif)
  • NT2RP70076430//Apolipoprotein A1/A4/E family
  • NT2RP70079250//F5/8 type C domain//Laminin G domain//Laminin G domain//EGF-like domain//Thrombospondin N-terminal-like domains//Laminin G domain
  • NT2RP70079750//Laminin G domain
  • NT2RP70081370//Herpesvirus glycoprotein M//ABC transporter//Ribosomal S17
  • NT2RP70081440//Eukaryotic protein kinase domain
  • NT2RP70081670//Helix-hairpin-helix motif.//S1 RNA binding domain
  • NT2RP70084060//Glycosyl transferases group 1
  • NT2RP70084410//Bromodomain//Bromodomain//Bromodomain//Bromodomain//Bromodomain//Bromodomain//BAH domain
  • NT2RP70084870//Sulfotransferase proteins
  • NT2RP70085500//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Fibronectin type III domain//Fibronectin type III domain//Fibronectin type III domain
  • NT2RP70085570//Heavy-metal-associated domain//HECT-domain (ubiquitin-transferase).
  • NT2RP70087200//KRAB box//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70088550//PH domain
  • NT2RP70090120//Cytochrome oxidase subunit II//Voltage gated chloride channels//CBS domain//CBS domain
  • NT2RP70090190//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NT2RP70091490//Sugar (and other) transporter
  • NT2RP70092360//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Thioredoxin//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Thioredoxin//Immunoglobulin domain//Adenovirus E3 region protein CR1//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
  • NT2RP70093220//CbiM//Voltage gated chloride channels//CBS domain//CBS domain
  • NT2RP70093700//WD domain, G-beta repeat//Virion host shutoff protein//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • NT2RP70093940//IPT/TIG domain
  • NT2RP70094810//Myelin proteolipid protein (PLP or lipophilin)//Influenza non-structural protein (NS1)//Protein of unknown function DUF67//Patched family//7 transmembrane receptor (metabotropic glutamate family)
  • NT2RP70094980//EGF-like domain//EGF-like domain//Trypsin Inhibitor like cysteine rich domain//EGF-like domain//EGF-like domain//Trypsin Inhibitor like cysteine rich domain//EGF-like domain//von Willebrand factor type C domain//von Willebrand factor type C domain//Metallothionein//von Willebrand factor type C domain//von Willebrand factor type C domain//von Willebrand factor type C domain//von Willebrand factor type C domain
  • NTONG10000520//BTB/POZ domain//Kelch motif//Kelch motif
  • NTONG10001300//HlyD family secretion protein//Biopterin-dependent aromatic amino acid hydroxylase//Caspase recruitment domain
  • NTONG10002570//Rhabdovirus spike glycoprotein
  • NTONG10002640//Phosphoglucomutase/phosphomannomutase
  • NTONG20003340//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NTONG20008780//Bacterial regulatory proteins, lacI family//Site-specific recombinases
  • NTONG20009660//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat
  • NTONG20015500//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • NTONG20016120//PH domain//Phosphoglycerate mutase family//Oxysterol-binding protein
  • OCBBF10000910//Sorbin homologous domain//Peptidase family M1//SH3 domain//SH3 domain//SH3 domain
  • OCBBF10001180//K+ channel tetramerisation domain
  • OCBBF10001190//DNA topoisomerase II (N-terminal region)
  • OCBBF10001220//BTB/POZ domain//Ketch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
  • OCBBF20002310//Leucine rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain
  • OCBBF20007190//Metallo-beta-lactamase superfamily
  • OCBBF20008240//bZIP transcription factor//tRNA synthetase class II (G, H, P, S and T)
  • OCBBF20010750//Spectrin repeat
  • OCBBF20011010//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//FYVE zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • OCBBF20011240//Glutathione S-transferases.
  • OCBBF20011400//WD domain, G-beta repeat//K+ channel tetramerisation domain//7-fold repeat in Clathrin and VPS
  • OCBBF20011760//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
  • OCBBF20012100//PAP2 superfamily
  • OCBBF20013070//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • OCBBF20014940//UBA domain
  • OCBBF20015270//Zinc finger, C2H2 type//Bacterial type II secretion system protein
  • OCBBF20015280//lactate/malate dehydrogenase
  • OCBBF20015860//ATP synthase Alpha chain, C terminal
  • PEBLM10000340//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zn-finger in Ran binding protein and others.
  • PEBLM10000680//Actin
  • PEBLM20001120//Thymidylate kinase//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
  • PEBLM20002480//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • PEBLM20002700//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • PEBLM20003080//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • PEBLM20003950//SCAN domain
  • PEBLM20004790//Src homology domain 2//Eukaryotic protein kinase domain
  • PLACE50000370//7-fold repeat in Clathrin and VPS
  • PLACE50000580//Apolipoprotein A1/A4/E family
  • PLACE50000680//Sushi domain (SCR repeat)//Sushi domain (SCR repeat)
  • PLACE60002050//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • PLACE60003790//Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit.
  • PLACE60004290//Gag P30 core shell protein
  • PLACE60012810//AMP-binding enzyme
  • PLACE60014430//moaA/nifB/pqqE family//MoaC family
  • PLACE60018860//Adenylate and Guanylate cyclase catalytic domain
  • PLACE60021020//Integrase Zinc binding domain//Integrase Zinc binding domain//DnaJ central domain (4 repeats)
  • PLACE60021510//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • PLACE60026680//Sorbin homologous domain//SH3 domain//SH3 domain
  • PLACE60030380//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • PLACE60032040//Hirudin
  • PLACE60037050//ENV polyprotein (coat polyprotein)
  • PLACE60038500//Mitochondrial carrier proteins//Mitochondrial carrier proteins
  • PLACE60044640//Small cytokines (intecrine/chemokine), interleukin-8 like
  • PLACE60046630//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger
  • PROST10003430//PHD-finger//Zinc finger, C3HC4 type (RING finger)//TRAF-type zinc finger//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR or GLGF).//WHEP-TRS domain containing proteins//PDZ domain (Also known as DHR or GLGF).
  • PROST10005360//F5/8 type C domain//Laminin G domain//Laminin G domain//EGF-like domain//Fibrinogen beta and gamma chains, C-terminal globular domain
  • PROST20003250//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • PROST20018230//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • PROST20018990//ADP-ribosylation factor family//Ras family
  • PROST20023380//K+ channel tetramerisation domain//BTB/POZ domain
  • PROST20029600//Small cytokines (intecrine/chemokine), interleukin-8 like//Immunoglobulin domain
  • PROST20031170//Heavy-metal-associated domain//HECT-domain (ubiquitin-transferase).
  • PROST20033380//TPR Domain//TPR Domain//TPR Domain
  • PROST20033400//Eukaryotic protein kinase domain
  • PROST20043320//Paramyxovirus nucleocapsid protein//SH3 domain
  • PROST20044160//Tropomyosins
  • PROST20051210//Protein phosphatase 2C//Protein phosphatase 2C
  • PROST20064500//Sulfotransferase proteins
  • PROST20067370//TRAF-type zinc finger//DnaJ central domain (4 repeats)
  • PROST20069880//Atrial natriuretic peptide
  • PROST20072890//K+ channel tetramerisation domain//BTB/POZ domain
  • PROST20073170//K+ channel tetramerisation domain//BTB/POZ domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger present in dystrophin, CBP/p300
  • PROST20073890//Platelet-derived growth factor (PDGF)
  • PROST20085160//Tropomyosins//Tropomyosins
  • PROST20094830//PH domain
  • PUAEN10003220//Photosystem I reaction centre subunit VIII
  • SALGL10000050//Permeases for cytosine/purines, uracil, thiamine, allantoin
  • SALGL10000650//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain
  • SALGL10001570//Colicin pore forming domain//MotA/TolQ/ExbB proton channel family
  • SKMUS10000140//Ubiquitin family//Ubiquitin family//Ubiquitin family//Ubiquitin family//Ubiquitin family//Ubiquitin family
  • SKMUS10000220//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • SKMUS10000640//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//PHD-finger//B-box zinc finger.//3′5′-cyclic nucleotide phosphodiesterase
  • SKMUS10001040//bZIP transcription factor
  • SKMUS10001180//Coronavirus S2 glycoprotein
  • SKMUS10001290//MutT-like domain
  • SKMUS10001770//Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT)
  • SKMUS20000740//ubiE/COQ5 methyltransferase family//Cyclopropane-fatty-acyl-phospholipid synthase
  • SKMUS20001170//ATP synthase Alpha chain, C terminal//MAGE family
  • SKMUS20002710//Hepatitis C virus capsid protein
  • SKMUS20003900//Mov34/MPN/PAD-1 family
  • SKMUS20004580//LIM domain containing proteins//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat//Nebulin repeat
  • SKMUS20007240//Thiamine pyrophosphate enzymes//Thiamine pyrophosphate enzymes//Thiamine pyrophosphate enzymes
  • SKMUS20008630//OB-fold nucleic acid binding domain//tRNA synthetases class II (F)//tRNA synthetases class II (D, K and N)
  • SKMUS20009540//F-box domain.
  • SKMUS20011290//Iron-containing alcohol dehydrogenases//Iron-containing alcohol dehydrogenases
  • SKMUS20013640//Laminin EGF-like (Domains III and V)
  • SKMUS20016340//HMG (high mobility group) box
  • SKMUS20016620//Ank repeat//Ank repeat//Glutamine amidotransferases class-II//Ank repeat
  • SKMUS20016680//Phorbol esters/diacylglycerol binding domain (C1 domain)//CONSTANS family zinc finger//SH3 domain
  • SKNMC10000290//Zinc finger C-x8-C-x5-C-x3-H type (and similar).
  • SKNMC10002510//ABC transporter transmembrane region.//Phosphoribulokinase//ATPases associated with various cellular activities (AAA)//ABC transporter
  • SKNMC20000650//Zinc finger, C2H2 type//Protein phosphatase 2C//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • SKNMC20000970//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Elongation factor TS//Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT)//Met-10+ like-proteins
  • SKNMC20002240//KRAB box//Zinc finger, C2H2 type//LIM domain containing proteins//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//LIM domain containing proteins//PHD-finger//Zinc finger, C2H2 type
  • SKNMC20003560//Helix-loop-helix DNA-binding domain
  • SKNMC20010570//F-box domain.
  • SKNMC20015030//Keratin, high sulfur B2 protein
  • SKNMC20015960//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Bacterial stress protein//Ank repeat//Formylmethanofuran-tetrahydromethanopterin formyltransferase//Ank repeat//Ank repeat//Ank repeat//Neuraxin and MAP1B proteins//FYVE zinc finger
  • SKNSH10001740//Pyridoxal-dependent decarboxylase
  • SKNSH10003010//SH3 domain
  • SKNSH20003470//Heme-binding domain in cytochrome b5 and oxidoreductases
  • SMINT10000160//UDP-glucoronosyl and UDP-glucosyl transferases
  • SMINT10000420//Cytochrome oxidase subunit II//ABC transporter//Biopterin-dependent aromatic amino acid hydroxylase
  • SMINT10000570//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
  • SMINT10000710//Immunoglobulin domain
  • SMINT10001030//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat
  • SMINT20002270//Disintegrin//Trans-activation protein X
  • SMINT20002770//Transcriptional regulatory protein, C terminal//Immunoglobulin domain
  • SPLEN10001430//HMG (high mobility group) box
  • SPLEN20000720//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • SPLEN20001340//Peptidase family M20/M25/M40
  • SPLEN20001970//Transcription factor TFIIB repeat
  • SPLEN20002670//WD domain, G-beta repeat
  • SPLEN20003570//RasGEF domain//Ras association (RaIGDS/AF-6) domain
  • STOMA10001860//Cytosolic long-chain acyl-CoA thioester hydrolase//OB-fold nucleic acid binding domain//Cytosolic long-chain acyl-CoA thioester hydrolase
  • STOMA20000880//Immunoglobulin domain
  • STOMA20001210//Cys/Met metabolism PLP-dependent enzyme//Aminotransferases class-I
  • STOMA20002570//MgtC family
  • STOMA20002890//Adaptin N terminal region
  • STOMA20003960//LIM domain containing proteins//LIM domain containing proteins
  • STOMA20004820//PH domain//EF hand//EF hand//Phosphatidylinositol-specific phospholipase C, X domain
  • SYNOV10001280//Lipoate-protein ligase B
  • SYNOV20013740//KRAB box//Bacterial type II secretion system protein I/J//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • SYNOV20014510//SRF-type transcription factor (DNA-binding and dimerisation domain)
  • SYNOV20016480//glycosyl transferase family
  • TESTI10000420//K-box region//Penicillin amidase
  • TESTI10000510//Transient receptor
  • TESTI10000550//Homeobox domain
  • TESTI10000640//K+ channel tetramerisation domain//BTB/POZ domain//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
  • TESTI10000700//Ubiquitin carboxyl-terminal hydrolases family 2//Ubiquitin carboxyl-terminal hydrolase family 2
  • TESTI10001270//PLAT/LH2 domain//PLAT/LH2 domain//PLAT/LH2 domain
  • TESTI10001380//Subtilase family//Proprotein convertase P-domain
  • TESTI10001680//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat
  • TESTI20001200//KRAB box
  • TESTI20001540//Eukaryotic protein kinase domain
  • TESTI20001770//von Willebrand factor type A domain//Proprotein convertase P-domain
  • TESTI20002070//NifU-like N terminal domain
  • TESTI20002380//Exonuclease//3′-5′ exonuclease
  • TESTI20002530//Ubiquitin family
  • TESTI20003560//Tubulin/FtsZ family
  • TESTI20005910//Adenylate kinase//Elongation factor Tu family//Adenylate kinase//6-phosphofructo-2-kinase//Shikimate kinase//pKID domain//Adenylate kinase//Thymidylate kinase//ATPases associated with various cellular activities (AAA)
  • TESTI20006000//Ank repeat//CAP-Gly domain
  • TESTI20006270//TPR Domain//TPR Domain//TPR Domain//4-hydroxyphenylpyruvate dioxygenase C terminal domain//TPR Domain//TPR Domain
  • TESTI20006950//Tudor domain//Stathmin family
  • TESTI20006990//KOW motif//Kinesin motor domain
  • TESTI20007070//DM DNA binding domain
  • TESTI20007840//Apolipoprotein A1/A4/E family
  • TESTI20008490//Apolipoprotein A1/A4/E family
  • TESTI20008830//Immunoglobulin domain
  • TESTI20010490//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TESTI20011410//RhoGEF domain//PH domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//CXXC zinc finger//FYVE zinc finger//PH domain
  • TESTI20012370//K+ channel tetramerisation domain//BTB/POZ domain//Ornithine decarboxylase antizyme//Kelch motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif
  • TESTI20012690//Biotin-requiring enzymes//Biotin-requiring enzymes//2-oxo acid dehydrogenases acyltransferase (catalytic domain)
  • TESTI20013300//EF hand//EF hand//Ubiquitin carboxyl-terminal hydrolases family 2
  • TESTI20013450//Double-stranded RNA binding motif//Aldehyde oxidase and xanthine dehydrogenase, C terminus//Adenosine-deaminase (editase) domain
  • TESTI20014200//ABC 3 transport family//Sugar (and other) transporter
  • TESTI20015110//bZIP transcription factor//Troponin//Domain of unknown function DUF87
  • TESTI20015560//K+ channel tetramerisation domain//BTB/POZ domain
  • TESTI20016610//Leptin
  • TESTI20018150//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TESTI20018270//Transketolase//Dehydrogenase E1 component//Transketolase
  • TESTI20018520//F5/8 type C domain//Laminin G domain//Ribosomal protein L11//Thrombospondin N-terminal-like domains//Laminin G domain//EGF-like domain//Fibrinogen beta and gamma chains, C-terminal globular domain
  • TESTI20018690//SAM domain (Sterile alpha motif)
  • TESTI20018790//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TESTI20020570//E1 Protein, N terminal domain//Actin
  • TESTI20020810//7 transmembrane receptor (metabotropic glutamate family)//Transmembrane amino acid transporter protein
  • TESTI20021050//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain
  • TESTI20021490//BTB/POZ domain//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TESTI20022230//Nucleosome assembly protein (NAP)
  • TESTI20022510//Calreticulin family//PHD-finger
  • TESTI20022560//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Guanylate kinase//Vesiculovirus phosphoprotein
  • TESTI20024980//PDZ domain (Also known as DHR or GLGF).//SH3 domain//Guanylate kinase
  • TESTI20025160//MAGE family
  • TESTI20025800//lactate/malate dehydrogenase//Pyridine nucleotide-disulphide oxidoreductase
  • TESTI20026760//SPRY domain
  • TESTI20027070//Type I phosphodiesterase/nucleotide pyrophosphatase
  • TESTI20027290//RhoGAP domain
  • TESTI20027890//KRAB box//Dictyostelium (s lime mold) repeats//Dictyostelium (slime mold) repeats//Zinc finger, C2H2 type//Dictyostelium (slime mold) repeats//Zinc finger, C2H2 type//Dictyostelium (slime mold) repeats
  • TESTI20029120//Eukaryotic protein kinase domain
  • TESTI20030050//Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  • TESTI20030370//MYND finger//TPR Domain//TPR Domain//TPR Domain//Adaptin N terminal region
  • TESTI20030710//Herpesvirus UL25 family
  • TESTI20031090//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats//Armadillo/beta-catenin-like repeats
  • TESTI20031300//TPR Domain
  • TESTI20031520//mRNA capping enzyme
  • TESTI20031960//WD domain, G-beta repeat
  • TESTI20032280//Myb-like DNA-binding domain
  • TESTI20033250//UBX domain//Orotidine 5′-phosphate decarboxylases
  • TESTI20033270//DM DNA binding domain
  • TESTI20033540//Zinc finger, C2H2 type
  • TESTI20033560//F-box domain.
  • TESTI20034190//ATP synthase Alpha chain, C terminal//AMP-binding enzyme
  • TESTI20034980//RhoGEF domain
  • TESTI20035120//C2 domain//Kinesin motor domain
  • TESTI20035510//NOL1/NOP2/sun family
  • TESTI20035890//UBA domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar).
  • TESTI20036250//TSC-22/dip/bun family//NAD dependent epimerase/dehydratase family//Adenylate kinase//ATPases associated with various cellular activities (AAA)
  • TESTI20037810//Eukaryotic protein kinase domain
  • TESTI20038940//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif
  • TESTI20040000//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family
  • TESTI20040310//Protein of unknown function DUF84
  • TESTI20041220//VPR/VPX protein
  • TESTI20042870//ET module
  • TESTI20042950//3′5′-cyclic nucleotide phosphodiesterase//Peptidase family M1
  • TESTI20049820//Cyclic nucleotide-binding domain
  • TESTI20053960//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TESTI20055840//PH domain//PH domain
  • TESTI20056900//Urease, gamma subunit//IQ calmodulin-binding motif//IQ calmodulin-binding motif
  • TESTI20057310//Tropomyosins
  • TESTI20057420//Acyl CoA binding protein//Ribosomal Proteins L2
  • TESTI20064830//Tetrahydrofolate dehydrogenase/cyclohydrolase
  • TESTI20068660//Domain of unknown function DUF19//TPR Domain//TPR Domain//TPR Domain
  • TESTI20068720//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TESTI20074640//KRAB box//Zinc finger, C2H2 type//MYND finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TESTI20074660//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//MYND finger//Zinc finger, C2H2 type
  • TESTI20074800//Glypican
  • TESTI20077490//Signal peptidase (SPase) II
  • TESTI20078640//SCAN domain
  • TESTI20078720//ATP synthase B/B′ CF(0)//Ribosomal L29 protein
  • TESTI20079510//Immunoglobulin domain//Immunoglobulin domain//Adenovirus E3 region protein CR1//Immunoglobulin domain//Immunoglobulin domain//Fibronectin type III domain//Fibronectin type III domain
  • TESTI20080200//MttB family UPF0032
  • TESTI20080330//Ribosomal protein L14p/L23e
  • TESTI20083430//TPR Domain
  • TESTI20083870//EF hand//EF hand//EF hand//Phosphatidylinositol 3- and 4-kinases//EF hand
  • TESTI20086570//MAGE family
  • TESTI20087740//TPR Domain//TPR Domain//Outer membrane efflux protein//TPR Domain//TPR Domain
  • TESTI20138320//Transketolase
  • TESTI20140360//metallopeptidase family M24
  • TESTI20177400//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • THYMU10000830//FAD binding domain
  • THYMU10001760//Immunoglobulin domain
  • THYMU10002910//Adaptin N terminal region
  • THYMU10003590//PH domain//RhoGAP domain
  • THYMU10004590//HMG (high mobility group) box
  • THYMU10005580//Synaptobrevin
  • THYMU20002360//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)
  • THYMU20003690//Prokaryotic DNA topoisomerase//Protein of unknown function DUF122//Eukaryotic protein kinase domain
  • TRACH10000740//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
  • TRACH10001250//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain//Immunoglobulin domain
  • TRACH20000150//Fatty acid desaturase//Protein phosphatase 2C
  • TRACH20001850//Molluscan rhodopsin C-terminal tail
  • TRACH20002370//KRAB box//Zinc finger, C2H2 type//FYVE zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • TRACH20002500//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta repeat
  • TRACH20002890//PH domain//Src homology domain 2
  • TRACH20003930//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • TRACH20004110//Zinc finger, C2H2 type
  • TRACH20004200//Neurohypophysial hormones, C-terminal Domain//Keratin, high sulfur B2 protein
  • TRACH20004720//Aminotransferases class-II//Aminotransferases class-I
  • TRACH20004960//AMP-binding enzyme
  • TRACH20006650//LacY proton/sugar symporter//Sugar (and other) transporter
  • TRACH20006750//E1 Protein, N terminal domain//ATP synthase (E/31 kDa) subunit
  • TRACH20009260//short chain dehydrogenase
  • TRACH20012890//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
  • TRACH20016070//Adenylate cyclase
  • UMVEN10001220//Corticotropin-releasing factor family
  • UMVEN20001330//C2 domain//C2 domain//C2 domain
  • UTERU10001600//SCAN domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
  • UTERU10001920//Integrase core domain
    • EXAMPLE 6 Functional Categorization Based on the Full-Length Nucleotide Sequences
  • The functional prediction and categorization of the proteins encoded by the clones were carried out based on the result of homology search of the databases of GenBank, Swiss-Prot, UniGene and nr (see the Homology Search Result Data) for the full-length nucleotide sequences and the result of domain search of the amino acid sequences deduced from the full-length nucleotide sequences (see Example 5).
  • The clone predicted to belong to the category of secretory protein/membrane protein means a clone having hit data with some annotation, such as growth factor, cytokine, hormone, signal, transmembrane, membrane, extracellular matrix, receptor, G-protein coupled receptor, ionic channel, voltage-gated channel, calcium channel, cell adhesion, collagen, connective tissue, etc., suggesting that it is a secretory or membrane protein, or means a clone in which the presence of nucleotide sequence encoding a signal sequence or transmembrane domain was suggested by the results of PSORT and SOSUI analyses for deduced ORF.
  • The clone predicted to belong to the category of glycoprotein-related protein means a clone having hit data with some annotation, such as glycoprotein, suggesting that the clone encodes a glycoprotein-related protein.
  • The clone predicted to belong to the category of signal transduction-related protein means a clone having hit data with some annotation, such as serine/threonine-protein kinase, tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting that the clone encodes a signal transduction-related protein.
  • The clone predicted to belong to the category of transcription-related protein means a clone having hit data with some annotation, such as transcription regulation, zinc finger, homeobox, etc., suggesting that the clone encodes a transcription-related protein.
  • The clone predicted to belong to the category of disease-related protein means a clone having hit data with some annotation, such as disease mutation, syndrome, etc., suggesting that the clone encodes a disease-related protein, or means a clone whose full-length nucleotide sequence has hit data for Swiss-Prot, GenBank, or UniGene, where the hit data corresponds to genes or proteins which have been deposited in the Online Mendelian Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/), which is the human gene and disease database.
  • The clone predicted to belong to the category of enzyme and/or metabolism-related protein means a clone having hit data with some annotation, such as metabolism, oxidoreductase, E. C. No. (Enzyme commission number), etc., suggesting that the clone encodes an enzyme and/or metabolism-related protein.
  • The clone predicted to belong to the category of cell division and/or cell proliferation-related protein means a clone having hit data with some annotation, such as cell division, cell cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc., suggesting that the clone encodes a cell division and/or cell proliferation-related protein.
  • The clone predicted to belong to the category of cytoskeleton-related protein means a clone having hit data with some annotation, such as structural protein, cytoskeleton, actin-binding, microtubles, etc., suggesting that the clone encodes a cytoskeleton-related protein.
  • The clone which is predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein means a clone having hit data with some annotation, such as nuclear protein, RNA splicing, RNA processing, RNA helicase, polyadenylation, etc., suggesting that the clone encodes a nuclear protein and/or RNA synthesis-related protein.
  • The clone predicted to belong to the category of protein synthesis and/or transport-related protein means a clone having hit data with some annotation, such as translation regulation, protein biosynthesis, amino-acid biosynthesis, ribosomal protein, protein transport, signal recognition particle, etc., suggesting that the clone encodes a protein synthesis and/or transport-related protein.
  • The clone predicted to belong to the category of cellular defense-related protein means a clone having hit data with some annotation, such as heat shock, DNA repair, DNA damage, etc., suggesting that the clone encodes a cellular defense-related protein.
  • The clone predicted to belong to the category of development and/or differentiation-related proteins means a clone having hit data with some annotation, such as developmental protein, etc., suggesting that the clone encodes a development and/or differentiation-related protein.
  • The clone predicted to belong to the category of DNA-binding and/or RNA-binding protein means a clone having hit data with some annotation, such as DNA-binding, RNA-binding, etc.
  • The clone predicted to belong to the category of ATP-binding and/or GTP-binding protein means a clone having hit data with some annotation, such as ATP-binding, GTP-binding, etc.
  • In this functional categorization, when a single clone corresponded to multiple categories of those shown above, the clone was assigned to the multiple categories. However, the function of a protein is not restricted to the functional category in this classification, and there is the possibility that other functions are newly assigned to the protein.
  • The clones predicted to belong to the category of secretory protein and/or membrane protein are the following 439 clones.
  • 3NB6910000180, 3NB6910000850, 3NB6920000290, 3NB6920003300, 3NB6920005450, 3NB6920010020, ADRGL10000180, ADRGL10001600, ADRGL20003230, BGGI120010970, BNGH410000340, BNGH410001040, BNGH410001180, BNGH410001370, BNGH410001980, BRACE10000730, BRACE10001690, BRACE20002800, BRACE20007180, BRACE20010650, BRACE20011170, BRACE20011430, BRACE20013400, BRACE20013520, BRACE20014230, BRACE20014530, BRACE20014920, BRACE20015080, BRACE20018590, BRACE20022270, BRACE20024680, BRACE20026350, BRACE20026850, BRACE20030780, BRACE20031100, BRACE20034490, BRACE20071380, BRACE20071970, BRACE20072810, BRACE20074010, BRACE20074470, BRACE20075020, BRACE20075380, BRACE20076410, BRACE20076630, BRACE20076850, BRACE20077610, BRACE20077640, BRACE20077980, BRACE20078680, BRACE20079530, BRACE20084430, BRACE20086550, BRACE20089600, BRACE20091880, BRAWH10000010, BRAWH10000370, BRAWH10000940, BRAWH10001620, BRAWH10001800, BRAWH20001090, BRAWH20004430, BRAWH20006970, BRAWH20009840, BRAWH20011290, BRAWH20011410, BRAWH20011660, BRAWH20014380, BRAWH20014840, BRAWH20015030, BRAWH20036930, BRAWH20038320, BRAWH20040950, BRAWH20052250, BRAWH20059980, BRAWH20087060, BRAWH20092610, CD34C20000510, CTONG20013660, CTONG20015330, CTONG20028160, CTONG20037820, CTONG20047160, DFNES20003350, FCBBF10006180, FCBBF10006750, FCBBF20005910, FCBBF20007330, FCBBF20008150, FCBBF20009400, FCBBF20015380, FEBRA20003780, FEBRA20004040, FEBRA20004150, FEBRA20004520, FEBRA20004910, FEBRA20006560, FEBRA20006900, FEBRA20007330, FEBRA20008090, FEBRA20008800, FEBRA20010930, FEBRA20012270, FEBRA20012450, FEBRA20012940, FEBRA20013510, FEBRA20014870, FEBRA20014920, FEBRA20015840, FEBRA20020860, FEBRA20021910, FEBRA20025250, FEBRA20031550, FEBRA20037070, FEBRA20041100, FEBRA20041910, FEBRA20057780, FEBRA20063150, FEBRA20066670, FEBRA20067930, HCASM10000610, HCASM20002020, HEART20000990, HEART20004920, HHDPC20000950, HLUNG10000240, HLUNG10000370, HLUNG10001100, HLUNG20001160, HLUNG20001250, HLUNG20001420, HLUNG20001760, HLUNG20002550, HSYRA20003470, HSYRA20006290, HSYRA20008280, HSYRA20011030, HSYRA20013320, HSYRA20014200, HSYRA20015800, IMR3210000440, IMR3210001580, IMR3210002660, IMR3220007750, IMR3220008590, IMR3220009840, IMR3220014350, KIDNE10000080, KIDNE10001040, KIDNE10001430, KIDNE20000700, KIDNE20000850, KIDNE20001670, KIDNE20003150, KIDNE20003300, KIDNE20003490, KIDNE20004220, KIDNE20005170, KIDNE20005190, KIDNE20033050, KIDNE20033570, KIDNE20039410, KIDNE20042620, KIDNE20042950, KIDNE20044110, KIDNE20048280, KIDNE20049810, KIDNE20054000, KIDNE20054770, KIDNE20060530, KIDNE20060620, KIDNE20063530, KIDNE20063760, KIDNE20066520, KIDNE20067600, KIDNE20071860, KIDNE20073520, KIDNE20074220, KIDNE20075690, LIVER10000580, LIVER10000670, LIVER10001040, LIVER10001110, LIVER10001750, LIVER10005420, LIVER20004160, MAMGL10000320, MAMGL10001840, MESAN10000350, MESAN10001470, MESAN10001800, MESAN20001490, NB9N420000420, NHNPC20002060, NT2NE10000230, NT2NE10000830, NT2NE10001630, NT2NE20003270, NT2NE20003920, NT2NE20004550, NT2NE20004700, NT2NE20005500, NT2NE20012470, NT2NE20014350, NT2NE20016260, NT2NE20034080, NT2NE20047160, NT2NE20055170, NT2NE20057200, NT2RI20005970, NT2RI20009740, NT2RI20010100, NT2RI20014490, NT2RI20015400, NT2RI20015950, NT2RI20016570, NT2RI20018660, NT2RI20020220, NT2RI20021520, NT2RI20022430, NT2RI20022520, NT2RI20025300, NT2RI20030110, NT2RI20030510, NT2RI20031540, NT2RI20033010, NT2RI20033830, NT2RI20036780, NT2RI20042840, NT2RI20044420, NT2RI20049850, NT2RI20050870, NT2RI20051500, NT2RI20066820, NT2RI20068250, NT2RI20070480, NT2RI20070840, NT2RI20073030, NT2RI20074980, NT2RI20077540, NT2RI20078270, NT2RI20080500, NT2RI20081880, NT2RI20084810, NT2RI20085980, NT2RI20089420, NT2RI20092890, NT2RI20094060, NT2RP60000320, NT2RP60000390, NT2RP60001090, NT2RP70000690, NT2RP70002380, NT2RP70002590, NT2RP70003640, NT2RP70011660, NT2RP70015910, NT2RP70021510, NT2RP70023760, NT2RP70023790, NT2RP70026190, NT2RP70029820, NT2RP70040800, NT2RP70043730, NT2RP70047900, NT2RP70049250, NT2RP70055200, NT2RP70064080, NT2RP70071540, NT2RP70071770, NT2RP70073810, NT2RP70074220, NT2RP70075040, NT2RP70076170, NT2RP70079250, NT2RP70079750, NT2RP70081330, NT2RP70081370, NT2RP70083150, NT2RP70085500, NT2RP70090120, NT2RP70091490, NT2RP70091680, NT2RP70092360, NT2RP70093220, NT2RP70093730, NT2RP70094290, NT2RP70094810, NT2RP70094980, NT2RP70095070, NTONG10000980, NTONG10002140, NTONG10002570, NTONG20002650, NTONG20004920, NTONG20008000, NTONG20012220, OCBBF10000420, OCBBF20002310, OCBBF20009980, OCBBF20012100, PANCR10000210, PLACE50000670, PLACE50000680, PLACE50001050, PLACE50001130, PLACE60012810, PLACE60018860, PLACE60020160, PLACE60020840, PLACE60026990, PLACE60037050, PLACE60037450, PLACE60043960, PLACE60044540, PLACE60047380, PLACE60049930, PLACE60050290, PROST10002200, PROST10002720, PROST10005260, PROST10005360, PROST20000360, PROST20026820, PROST20029600, PROST20032320, PROST20033020, PROST20039220, PROST20044160, PROST20051430, PROST20054260, PROST20058800, PROST20059190, PROST20059430, PROST20069880, PROST20072370, PROST20073890, PUAEN10000570, PUAEN10003220, SALGL10001570, SKMUS20007740, SKNMC10000190, SKNMC10000290, SKNMC10002290, SKNMC10002510, SKNMC20011130, SKNMC20015030, SMINT10000160, SMINT10000420, SMINT10000570, SMINT10001180, SMINT20000180, SMINT20002770, SPLEN10000910, SPLEN20001340, SPLEN20002430, SPLEN20002700, SPLEN20003100, SPLEN20004960, STOMA10000520, STOMA10001170, STOMA20000320, STOMA20002570, SYNOV20001770, SYNOV20016480, TESTI10000420, TESTI10000960, TESTI10001270, TESTI10001380, TESTI20001770, TESTI20006000, TESTI20007620, TESTI20008830, TESTI20009090, TESTI20009700, TESTI20011340, TESTI20012370, TESTI20013520, TESTI20014200, TESTI20016210, TESTI20016710, TESTI20018520, TESTI20018620, TESTI20020020, TESTI20020810, TESTI20022510, TESTI20024230, TESTI20024650, TESTI20024670, TESTI20025800, TESTI20026320, TESTI20026980, TESTI20027000, TESTI20027070, TESTI20028660, TESTI20030370, TESTI20031930, TESTI20034190, TESTI20036490, TESTI20039980, TESTI20042870, TESTI20047120, TESTI20049940, TESTI20056900, TESTI20057420, TESTI20058600, TESTI20067740, TESTI20069780, TESTI20074800, TESTI20077490, TESTI20079510, TESTI20080200, TESTI20081440, TESTI20087740, TESTI20088470, TESTI20136910, THYMU10000830, THYMU10001760, THYMU10003290, THYMU10003820, THYMU10005580, TRACH10000630, TRACH10001000, TRACH10001400, TRACH20001850, TRACH20001960, TRACH20004200, TRACH20004960, TRACH20006650, TRACH20007670, TRACH20008980, TRACH20015920, UMVEN20001330, UTERU10000770, UTERU10000960, UTERU10001920, UTERU20000470, UTERU20003930, UTERU20004850
  • The clones predicted to belong to the category of glycoprotein-related protein are the following 87 clones.
  • BNGH410000340, BNGH410001180, BRACE20014920, BRACE20015080, BRACE20018590, BRACE20024680, BRACE20026350, BRACE20031100, BRACE20074470, BRAWH10000370, BRAWH20001090, BRAWH20011660, BRAWH20014840, BRAWH20059980, CD34C20000510, CTONG20013660, CTONG20028160, CTONG20037820, FCBBF20007330, FEBRA20007330, FEBRA20008800, FEBRA20014920, FEBRA20015840, FEBRA20057780, HEART20005060, HLUNG10001100, HLUNG20002550, HSYRA20013320, IMR3210002660, IMR3220007750, IMR3220013320, KIDNE20044110, KIDNE20063760, KIDNE20067600, KIDNE20073520, LIVER20000370, MESAN10000350, NT2NE10000830, NT2NE10001850, NT2NE20003270, NT2NE20016260, NT2RI20018660, NT2RI20025300, NT2RI20036780, NT2RI20077540, NT2RI20080500, NT2RI20085980, NT2RI20089420, NT2RI20092890, NT2RP70000690, NT2RP70004770, NT2RP70055200, NT2RP70081370, NT2RP70083150, NT2RP70091490, NT2RP70092360, NT2RP70094980, NTONG10002140, OCBBF20002310, OCBBF20002770, PLACE50000680, PLACE50001130, PLACE60018860, PLACE60044540, PROST20018230, PROST20032320, PROST20073890, SALGL10001570, SKNMC20015030, SMINT10000160, SMINT20002770, SPLEN20001340, TESTI10001270, TESTI10001380, TESTI20001770, TESTI20024230, TESTI20027070, TESTI20036490, TESTI20039980, TESTI20056900, TESTI20057420, TESTI20079510, THYMU10001760, TRACH10000740, TRACH10001250, TRACH20004200, UTERU20000470
  • The clones predicted to belong to the category of signal transduction-related protein are the following 46 clones.
  • ADRGL20000740, ASTRO10000180, BRACE20005770, BRACE20022020, BRACE20027360, BRACE20027920, BRAWH20006860, CTONG20005890, FEBRA20000350, HHDPC20000550, IMR3220003020, KIDNE20033730, KIDNE20040840, KIDNE20053360, KIDNE20062990, NT2RI20033440, NT2RI20058110, NT2RI20062100, NT2RI20073840, NT2RP70006240, NT2RP70043960, NT2RP70046870, NT2RP70061880, NT2RP70072520, NT2RP70081440, NT2RP70093700, NTONG10001820, PEBLM20004790, PLACE60026680, PROST20033400, PROST20043320, SKMUS10000220, SKMUS20016680, SPLEN20003570, TESTI20001540, TESTI20005910, TESTI20022560, TESTI20024980, TESTI20029120, TESTI20034980, TESTI20049820, TESTI20055840, THYMU10003590, THYMU20003690, TRACH20002500, TRACH20002890
  • The clones predicted to belong to the category of transcription-related protein are the following 140 clones.
  • 3NB6920010220, 3NB6920015110, 3NB6920015570, ADRGL10000650, BGGI120006840, BGGI120006930, BGGI120017140, BNGH410000800, BNGH420005320, BRACE10000930, BRACE20014550, BRACE20018550, BRACE20020910, BRACE20024090, BRACE20071740, BRAWH10000020, BRAWH10001640, BRAWH10001680, BRAWH20006330, BRAWH20009010, CTONG20025580, CTONG20028200, FCBBF10005980, FCBBF20000940, FCBBF20009510, FCBBF50002610, FEBRA20003970, FEBRA20003990, FEBRA20004540, FEBRA20009720, FEBRA20011460, FEBRA20017150, FEBRA20050140, FEBRA20064760, FEBRA20067360, FEBRA20069420, FEBRA20072800, HLUNG10000760, HLUNG20000680, HSYRA10001370, HSYRA20016310, IMR3210002420, IMR3220007420, KIDNE20000510, KIDNE20039940, KIDNE20061490, KIDNE20078110, NESOP10000870, NHNPC10001240, NHNPC20002120, NT2NE20002590, NT2NE20008090, NT2RI20003410, NT2RI20004120, NT2RI20004210, NT2RI20010830, NT2RI20018460, NT2RI20025410, NT2RI20025850, NT2RI20060710, NT2RI20067350, NT2RI20071330, NT2RI20074390, NT2RI20078790, NT2RI20087140, NT2RI20090650, NT2RI20092150, NT2RP60001000, NT2RP60001270, NT2RP70002710, NT2RP70008120, NT2RP70018560, NT2RP70024500, NT2RP70032030, NT2RP70036290, NT2RP70042040, NT2RP70045410, NT2RP70046560, NT2RP70055130, NT2RP70061620, NT2RP70062960, NT2RP70064900, NT2RP70069860, NT2RP70075370, NT2RP70085570, NT2RP70087200, NT2RP70090190, NTONG20003340, NTONG20003630, NTONG20015500, OCBBF20011010, OCBBF20011240, OCBBF20015860, PEBLM20002480, PEBLM20002700, PEBLM20003080, PEBLM20003950, PLACE60002050, PLACE60005550, PLACE60021510, PLACE60030380, PROST20018230, PROST20031170, PROST20073170, PUAEN10001610, SALGL10000650, SKMUS10000640, SKMUS20014920, SKNMC20000650, SKNMC20002240, SKNMC20003560, SMINT10001000, SMINT20005450, SPLEN20000200, SPLEN20000720, SYNOV20010140, SYNOV20013740, SYNOV20014510, TESTI10000550, TESTI20001200, TESTI20007070, TESTI20010490, TESTI20015560, TESTI20018150, TESTI20018790, TESTI20021490, TESTI20026760, TESTI20027890, TESTI20030710, TESTI20034130, TESTI20042290, TESTI20053960, TESTI20074640, TESTI20074660, TESTI20078640, THYMU10004590, TRACH20000790, TRACH20002370, TRACH20009440, UTERU10001600
  • The clones predicted to belong to the category of disease-related protein are the following 219 clones. Further, hit data of all the clones for Swiss-Prot, or GenBank, UniGene, or nr corresponded to genes or proteins which had been deposited in the Online Mendelian Inheritance in Man (OMIM), which is the human gene and disease database, (the OMIM Number is shown in the parenthesis after the Clone Name).
  • ADRGL10000020 (605332), ADRGL10001600 (201910), ADRGL20000740 (300118), ASTRO20004170 (605937), BGGI120006840 (604480), BGGI120010970 (602346), BGGI120017140 (194631), BNGH410001770 (146690), BNGH420005320 (601260), BRACE10001870 (157132), BRACE20006980 (106410), BRACE20007180 (114160), BRACE20014550 (140580), BRACE20018550 (109560), BRACE20018590 (602644), BRACE20027550 (179715), BRACE20027720 (138760), BRACE20076850 (605209), BRACE20086550 (603540), BRAWH10000020 (605678), BRAWH10001640 (606043), BRAWH20001770 (138450), BRAWH20005030 (179715), BRAWH20005220 (603747), BRAWH20006330 (194500), BRAWH20006860 (602958), BRAWH20009840 (601258), BRAWH20011660 (230500; 230600; 230650; 253010), CD34C20000510 (600031), CTONG20005890 (603583), CTONG20019110 (603486), CTONG20024180 (602895), CTONG20025580 (601856), CTONG20037820 (602729), CTONG20055530 (106410), FCBBF20000940 (601408), FCBBF20009510 (194531), FCBBF40002820 (130410), FEBRA20001050 (600025), FEBRA20003990 (601781), FEBRA20004150 (126650; 214700), FEBRA20004540 (194558), FEBRA20009720 (602277), FEBRA20010930 (603878), FEBRA20011460 (603900), FEBRA20050790 (176879), FEBRA20057880 (604362), FEBRA20064760 (602277), FEBRA20067930 (602921), FEBRA20070170 (606098), FEBRA20075510 (179513), FEBRA20075660 (179715), HCASM20002140 (123834), HEART20004480 (191045; 115195), HLUNG10001050 (310400), HLUNG20000680 (300024), HSYRA10001370 (602277), HSYRA20006400 (601278), HSYRA20013320 (146732), HSYRA20016310 (604080), IMR3210000440 (601890), IMR3220007910 (313440), KIDNE10001040 (603217), KIDNE20003150 (602417), KIDNE20033730 (605216), KIDNE20042950 (120160), KIDNE20044110 (605239), KIDNE20050420 (214500), KIDNE20059080 (604276), KIDNE20063760 (231950), KIDNE20078110 (603430), LIVER10002300 (161015), LIVER10004330 (603197), LIVER20000330 (191161), LIVER20000370 (138670), MAMGL10001780 (603403), MESAN10001800 (606048), MESAN20002910 (142810), MESAN20005010 (602769), NB9N410001350 (179508), NHNPC10000840 (604819), NHNPC20002120 (194558), NT2NE10000730 (601905), NT2NE20002990 (147625), NT2NE20003690 (232000), NT2NE20005170 (603330), NT2NE20005360 (150370), NT2NE20006580 (605969), NT2NE20008090 (603899), NT2NE20013720 (180480), NT2NE20016340 (602184), NT2NE20055170 (128100), NT2RI20004120 (600140), NT2RI20004210 (314997), NT2RI20010910 (601940), NT2RI20014500 (190370), NT2RI20020410 (168730; 180990), NT2RI20029580 (605689), NT2RI20031540 (300061), NT2RI20033440 (601014), NT2RI20041900 (179715), NT2RI20056470 (123940), NT2RI20057230 (601940), NT2RI20067030 (603577), NT2RI20070960 (311030), NT2RI20074980 (603105), NT2RI20077540 (300112), NT2RI20080500 (142461), NT2RI20083960 (605612), NT2RI20084810 (603099), NT2RI20092150 (600834), NT2RI20092890 (603104), NT2RP60000350 (605612), NT2RP60001000 (314995), NT2RP60001230 (600025), NT2RP70000690 (158340; 113720), NT2RP70004250 (160776), NT2RP70028750 (179838), NT2RP70029060 (140571), NT2RP70032030 (602277), NT2RP70036290 (600005; 209920), NT2RP70042600 (160776), NT2RP70046560 (602410), NT2RP70049250 (601703), NT2RP70055020 (604581), NT2RP70062960 (133540), NT2RP70063040 (604061), NT2RP70065270 (300111), NT2RP70069860 (602277), NT2RP70071770 (603046), NT2RP70073810 (601439), NT2RP70074220 (313440), NT2RP70075370 (109092), NT2RP70079250 (602346), NT2RP70081440 (601335), NT2RP70090120 (602727), NT2RP70090190 (194558), NT2RP70093220 (300008; 300009; 310468), NT2RP70094980 (135820), NTONG10002460 (600856), NTONG20003630 (600140), NTONG20015500 (604077), OCBBF10001180 (191161), OCBBF20008240 (187790), PEBLM10000340 (133450), PEBLM20002480 (300024), PEBLM20003080 (604077), PEBLM20003950 (600834), PLACE50000800 (601797), PLACE60002050 (600013), PLACE60003790 (603403), PLACE60014430 (603707), PROST10001670 (313440), PROST10005360 (602346), PROST20002730 (601985; 188550), PROST20032320 (253220), PROST20033400 (300203), PROST20062600 (601940), PROST20072890 (191161), PROST20073890 (192240), PROST20085160 (191030; 164970), SALGL10001570 (603743), SKMUS10000140 (191340), SKMUS10001180 (601402), SKMUS10001290 (604055), SKMUS20000740 (605196), SKMUS20003900 (604850), SKMUS20007240 (604300), SKMUS20016340 (163906), SKNMC10002510 (605452), SKNMC20000650 (604078), SKNMC20003220 (117140), SMINT10000420 (601615), SMINT10000570 (604814), SMINT10001000 (603851), SMINT10001030 (605759), SMINT20004000 (601278), SPLEN10001430 (163905), SPLEN20001970 (601940), STOMA20000880 (147220), STOMA20003960 (300111), SYNOV20013740 (604076), SYNOV20014510 (600661), SYNOV20016480 (131222; 603041), TESTI10001270 (601313; 173900), TESTI10001310 (186982), TESTI20001200 (194510), TESTI20001770 (146650), TESTI20002530 (605440), TESTI20006000 (179838), TESTI20006990 (602591), TESTI20007620 (126650; 214700), TESTI20008830 (160794), TESTI20011800 (190370), TESTI20012690 (109720), TESTI20015120 (604700), TESTI20018520 (602346), TESTI20018790 (300024), TESTI20021490 (604073), TESTI20025160 (300097), TESTI20027070 (173335), TESTI20027290 (300127), TESTI20029120 (600855), TESTI20033250 (168730), TESTI20049820 (176894), TESTI20053960 (604074), TESTI20068660 (603395), TESTI20071830 (605769), TESTI20074640 (603899), TESTI20079510 (116930), TESTI20086570 (300153), TESTI20140360 (170100), THYMU10000830 (600857), THYMU10001760 (116930), THYMU10003590 (602857), THYMU10004910 (604908), TRACH20002370 (602277), UTERU10000960 (603931), UTERU20000470 (602070)
  • The clones predicted to belong to the category of enzyme and/or metabolism-related protein are the following 168 clones.
  • 3NB6920002810, ADRGL10001600, ADRGL10001650, BGGI120005330, BNGH410000340, BNGH410001770, BRACE10000420, BRACE20015080, BRACE20022020, BRACE20024680, BRACE20026850, BRACE20027360, BRACE20027720, BRACE20027920, BRACE20071380, BRACE20084430, BRAWH20001770, BRAWH20006510, BRAWH20006860, BRAWH20009840, BRAWH20011660, BRAWH20014180, BRAWH20014840, BRAWH20036890, BRAWH20059980, BRAWH20069890, BRAWH20089560, CTONG20013660, CTONG20019110, DFNES20002120, FCBBF20007330, FCBBF20015380, FEBRA20000350, FEBRA20001290, FEBRA20003110, FEBRA20024420, FEBRA20041100, FEBRA20045920, FEBRA20050790, FEBRA20052160, FEBRA20062700, FEBRA20063150, HEART20000350, HHDPC20000550, HHDPC20004550, HLUNG10001050, HLUNG20002550, HSYRA10001680, HSYRA20005100, HSYRA20015740, IMR3220008380, IMR3220009190, IMR3220012180, IMR3220013170, KIDNE20000410, KIDNE20003490, KIDNE20004220, KIDNE20005130, KIDNE20033050, KIDNE20040840, KIDNE20046810, KIDNE20056290, KIDNE20060530, KIDNE20063760, KIDNE20068800, KIDNE20073280, KIDNE20073520, KIDNE20078100, LIVER10000670, LIVER10002300, MAMGL10001780, MESAN20002910, MESAN20005010, NT2NE10000730, NT2NE10001850, NT2NE20002140, NT2NE20003270, NT2NE20003690, NT2NE20005860, NT2NE20013720, NT2NE20016340, NT2NE20016660, NT2RI10000480, NT2RI20010100, NT2RI20015400, NT2RI20020220, NT2RI20025300, NT2RI20033010, NT2RI20036780, NT2RI20037510, NT2RI20051500, NT2RI20068550, NT2RI20073840, NT2RI20074980, NT2RI20084810, NT2RI20087910, NT2RP70004770, NT2RP70006240, NT2RP70011660, NT2RP70026190, NT2RP70062960, NT2RP70072520, NT2RP70076100, NT2RP70081440, NT2RP70084060, NT2RP70085570, NT2RP70093700, NTONG10001820, OCBBF20008240, OCBBF20012100, OCBBF20014080, OCBBF20014940, PANCR10000210, PEBLM20004790, PLACE50001050, PLACE50001130, PLACE60003790, PLACE60012810, PLACE60018860, PLACE60044540, PROST20031170, PROST20032320, PROST20033400, PROST20051210, PROST20064500, SKMUS10001290, SKMUS10001770, SKMUS20000740, SKMUS20007240, SKMUS20008630, SKMUS20009330, SKMUS20011290, SKNSH10001740, SKNSH20003470, SMINT10000160, SPLEN20001340, STOMA10001860, STOMA20001210, STOMA20004820, SYNOV20016480, TESTI10000700, TESTI10001380, TESTI20001540, TESTI20005910, TESTI20012690, TESTI20018270, TESTI20022560, TESTI20027070, TESTI20029120, TESTI20034190, TESTI20034980, TESTI20040000, TESTI20042070, TESTI20042950, TESTI20047120, TESTI20049820, TESTI20138320, TESTI20140360, TESTI30000020, THYMU10000830, THYMU10004910, THYMU20003170, THYMU20003690, TRACH20000150, TRACH20004720, TRACH20004970, TRACH20009260, UTERU10000960
  • The clones predicted to belong to the category of cell division and/or cell proliferation-related protein are the following 23 clones.
  • BGGI120001610, BRACE20027550, BRACE20076850, BRAWH20005030, BRAWH20005220, FEBRA20075660, HCASM20002140, HLUNG10000640, IMR3220009730, NT2NE20003840, NT2RI20006850, NT2RI20041900, NT2RI20058110, NTONG10002460, NTONG20008780, SKMUS20016340, SKNMC20003220, SPLEN10001430, TESTI10001680, TESTI20001840, TESTI20021050, TESTI20035120, TESTI20057310
  • The clones predicted to belong to the category of cytoskeleton-related protein are the following 60 clones.
  • ADRGL10000020, BRACE20006980, BRACE20008850, BRACE20027960, BRACE20074470, BRACE20076630, BRACE20078820, BRACE20093070, BRAWH20000480, BRAWH20066220, CTONG20019550, CTONG20028160, CTONG20055530, DFNES20002680, FCBBF20005910, FEBRA20007720, FEBRA20008810, FEBRA20034290, FEBRA20043290, FEBRA20072000, HEART20004480, HEART20005200, HLUNG10001100, HSYRA20006050, IMR3220007910, KIDNE20040840, KIDNE20052960, NT2RI20014090, NT2RI20032220, NT2RI20058510, NT2RI20090660, NT2RP70000690, NT2RP70004250, NT2RP70028750, NT2RP70042600, NT2RP70049250, NT2RP70074220, NTONG20009660, OCBBF20011760, OCBBF20015280, PEBLM10000680, PROST10001670, PROST20033380, TESTI10000420, TESTI10000510, TESTI20003560, TESTI20004350, TESTI20006000, TESTI20006990, TESTI20008490, TESTI20008830, TESTI20011410, TESTI20015110, TESTI20016610, TESTI20020570, TESTI20024230, TESTI20031090, TESTI20031170, TESTI20039140, TESTI20078720
  • The clones predicted to belong to the category of nuclear protein and/or RNA synthesis-related protein are the following 59 clones.
  • 3NB6920002810, 3NB6920015280, BGGI120005440, BRACE10001150, BRACE20024780, BRACE20027550, BRAWH20005030, BRAWH20014180, BRAWH20069890, CTONG20024180, FEBRA20001290, FEBRA20075660, HEART20003090, HLUNG10000640, HSYRA10001680, HSYRA20005100, IMR3220008630, IMR3220012180, MAMGL10001780, NT2NE10001850, NT2NE20002140, NT2NE20003840, NT2NE20016660, NT2NE20054410, NT2RI20002820, NT2RI20006850, NT2RI20010910, NT2RI20025540, NT2RI20041900, NT2RI20053350, NT2RI20057230, NT2RI20060720, NT2RI20067030, NT2RI20068550, NT2RI20078840, NT2RI20087490, NT2RP70004770, NT2RP70013060, NT2RP70076430, NTONG20008780, PEBLM10000340, PLACE50000580, PLACE60003790, PROST20001760, PROST20062600, SKMUS10000220, SKMUS20016340, SKNMC20003220, SPLEN10001430, SPLEN20001970, TESTI10001680, TESTI20002530, TESTI20007840, TESTI20021050, TESTI20029120, TESTI20035120, TESTI20057310, TRACH20003930, TRACH20012890
  • The clones predicted to belong to the category of protein synthesis and/or transport-related protein are the following 24 clones.
  • BRACE20078680, FEBRA20075510, IMR3220008380, KIDNE20005190, KIDNE20050420, MESAN20002910, NB9N410001350, NT2NE20005360, NT2RI20032050, NT2RI20032220, NT2RP70000760, NT2RP70076430, NT2RP70093940, OCBBF20008240, PLACE50000580, PROST20000530, SKMUS20000740, SKMUS20008630, TESTI20007840, TESTI20015120, TESTI20018690, TESTI20078720, THYMU10005580, UMVEN20001330
  • The clones predicted to belong to the category of cellular defense-related protein are the following 6 clones.
  • BRACE20014550, NT2RI20037510, NT2RI20053350, NT2RP70029060, NT2RP70062960, PLACE50001700
  • The clones predicted to belong to the category of development and/or differentiation-related protein are the following 19 clones.
  • BGGI120006930, CTONG20028200, FCBBF50002610, FEBRA20014920, FEBRA20017150, FEBRA20060920, MAMGL10001820, NESOP10000870, NHNPC10001240, NT2RI20078790, NT2RP70008120, NT2RP70018560, NT2RP70045410, OCBBF20002770, SALGL10000650, SMINT10001000, TESTI10000550, TESTI20026760, TESTI20078140
  • The clones predicted to belong to the category of DNA-binding and/or RNA-binding protein are the following 158 clones.
  • 3NB6920002810, 3NB6920010220, 3NB6920015110, 3NB6920015570, ADRGL10000650, BGGI120006840, BGGI120006930, BNGH410000800, BNGH420005320, BRACE20014550, BRACE20020910, BRACE20024090, BRACE20024780, BRACE20071740, BRAWH10001640, BRAWH10001680, BRAWH20000340, BRAWH20006330, BRAWH20009010, BRAWH20014180, BRAWH20069890, CTONG20025580, CTONG20028200, D3OST20001840, FCBBF10005980, FCBBF20009510, FCBBF50002610, FEBRA20003970, FEBRA20003990, FEBRA20004540, FEBRA20008560, FEBRA20009720, FEBRA20017150, FEBRA20017900, FEBRA20050140, FEBRA20064760, FEBRA20067360, FEBRA20069420, FEBRA20072800, HEART20003090, HLUNG10000760, HSYRA10001370, HSYRA20016310, IMR3210002420, IMR3220007420, IMR3220008630, KIDNE20000510, KIDNE20039940, KIDNE20061490, KIDNE20078110, NESOP10000870, NHNPC10000840, NHNPC10001240, NHNPC20002120, NT2NE20002590, NT2NE20003840, NT2NE20008090, NT2NE20016660, NT2NE20054410, NT2RI20003410, NT2RI20004210, NT2RI20006850, NT2RI20010830, NT2RI20010910, NT2RI20025410, NT2RI20025850, NT2RI20057230, NT2RI20060710, NT2RI20067350, NT2RI20071330, NT2RI20074390, NT2RI20078790, NT2RI20078840, NT2RI20087140, NT2RI20087490, NT2RI20090650, NT2RP60001000, NT2RP60001270, NT2RP70002710, NT2RP70008120, NT2RP70013060, NT2RP70018560, NT2RP70024500, NT2RP70032030, NT2RP70042040, NT2RP70045410, NT2RP70046560, NT2RP70055130, NT2RP70061620, NT2RP70062960, NT2RP70064900, NT2RP70069860, NT2RP70075370, NT2RP70081670, NT2RP70085570, NT2RP70087200, NT2RP70090190, NTONG20003340, NTONG20008780, NTONG20015500, OCBBF20011010, OCBBF20015860, PEBLM10000340, PEBLM20001120, PEBLM20002700, PEBLM20003080, PLACE60002050, PLACE60005550, PLACE60021510, PLACE60030380, PROST20001760, PROST20003250, PROST20018230, PROST20031170, PROST20062600, PROST20073170, SALGL10000650, SKMUS10000640, SKMUS20014920, SKMUS20016340, SKNMC20000650, SKNMC20002240, SKNMC20003220, SKNMC20003560, SMINT10001000, SMINT20005450, SPLEN10001430, SPLEN20000200, SPLEN20000720, SPLEN20001970, SYNOV20010140, SYNOV20013740, SYNOV20014510, TESTI10000550, TESTI20001200, TESTI20007070, TESTI20010490, TESTI20013450, TESTI20015560, TESTI20018150, TESTI20021050, TESTI20021490, TESTI20026760, TESTI20027890, TESTI20030710, TESTI20033270, TESTI20034130, TESTI20035120, TESTI20053960, TESTI20074640, TESTI20074660, TESTI20078640, THYMU10004590, TRACH20000790, TRACH20002370, TRACH20009440, TRACH20012890, UTERU10001600
  • The clones predicted to belong to the category of ATP binding and/or GTP-binding protein are the following 63 clones.
  • 3NB6920002810, BNGH410000390, BRACE20022020, BRACE20028120, BRACE20071380, BRAWH20000480, BRAWH20006860, BRAWH20066220, CTONG20013200, DFNES20002680, FEBRA20043290, FEBRA20052160, FEBRA20072000, FEBRA20075510, HHDPC20000550, HLUNG20001160, HSYRA10001680, HSYRA20005100, HSYRA20006050, KIDNE20040840, MAMGL10001780, MESAN20002910, NB9N410001350, NT2NE20003690, NT2NE20005170, NT2NE20016660, NT2NE20055170, NT2RI20068550, NT2RI20073840, NT2RP70004250, NT2RP70011660, NT2RP70029060, NT2RP70036290, NT2RP70042600, NT2RP70046870, NT2RP70062960, NT2RP70081370, NT2RP70081440, NT2RP70093700, OCBBF20008240, OCBBF20015280, PEBLM20004790, PLACE50001700, PLACE60003790, PROST20018990, PROST20033400, SKMUS20008630, SMINT10000420, TESTI20001540, TESTI20003560, TESTI20005910, TESTI20006950, TESTI20006990, TESTI20008490, TESTI20015110, TESTI20016610, TESTI20022560, TESTI20029120, TESTI20034980, TESTI20042290, TESTI20047120, TESTI20049820, TESTI20057310
  • Among the clones other than the ones shown above, NTONG10001300 is a clone which was predicted to highly possibly belong to the category of secretory protein and/or membrane protein based on the result of domain search by Pfam.
  • FEBRA20017060, NT2RI20066790, SMINT10000710
  • The three clones shown above are clones which were predicted to highly possibly belong to the category of glycoprotein-related protein based on the result of domain search by Pfam.
  • BRACE20080970, BRACE20092120, BRAWH10001300, FEBRA20019890, KIDNE20031850, KIDNE20060140, MESAN20000920, NB9N410000470, NT2RI20071480, NT2RI20078910, NT2RP70088550, NTONG20016120, OCBBF10000910, PROST20094830, SKNSH10003010, SPLEN20002670, TESTI20031960, TESTI20036250, TESTI20037810, TESTI20083870, TESTI20177400
  • The 21 clones shown above are clones which were predicted to highly possibly belong to the category of signal transduction-related protein based on the result of domain search by Pfam.
  • 3NB6920009120, 3NB6920014710, BRACE10001660, BRACE20083850, BRAWH20004760, BRAWH20012030, CTONG20011390, CTONG20018200, FEBRA20007870, FEBRA20043250, HHDPC20003150, NT2RI10000270, NT2RI20036950, NT2RI20053680, NT2RI20072540, NT2RI20083360, NT2RP70030550, OCBBF20013070, OCBBF20015270, PLACE60046630, PROST10003430, PROST20067370, SKMUS10001040, SKNMC20015960, TESTI20030050, TESTI20033540, TESTI20035890, TESTI20068720, TRACH20004110
  • The 29 clones shown above are clones which were predicted to highly possibly belong to the category of transcription-related protein based on the result of domain search by Pfam.
  • BNGH410001900, BRACE20080970, BRACE20092120, BRAWH20093600, FEBRA20003770, FEBRA20024290, HLUNG10000990, KIDNE20004030, MESAN20000920, NB9N420001040, NT2NE10000140, NT2NE20001740, NT2RI20050610, NT2RI20055640, NT2RI20072540, NT2RI20074690, NT2RP60000860, NT2RP70036470, NT2RP70036800, NT2RP70072210, NT2RP70074060, NT2RP70084870, NTONG10001300, NTONG10002640, NTONG20016120, OCBBF10000910, OCBBF10001190, OCBBF20007190, SKMUS20001170, SKMUS20016620, SKNMC20000970, SKNMC20015960, SYNOV10001280, TESTI20002380, TESTI20006270, TESTI20013300, TESTI20031520, TESTI20036250, TESTI20037810, TESTI20064830, TESTI20083870, TRACH20006750, TRACH20016070
  • The 43 clones shown above are clones which were predicted to highly possibly belong to the category of enzyme and/or metabolism-related protein based on the result of domain search by Pfam.
  • NT2RI20064120
  • The clone shown above is a clone which were predicted to highly possibly belong to the category of cell division and/or cell proliferation-related protein based on the result of domain search by Pfam.
  • BRACE20083800, KIDNE20004970
  • The two clones shown above are clones which were predicted to highly possibly belong to the category of cytoskeleton-related protein based on the result of domain search by Pfam.
  • 3NB6920009120, 3NB6920014710, BRACE10001660, BRACE20083850, BRAWH20004760, BRAWH20012030, BRAWH20064500, CTONG20011390, CTONG20018200, FEBRA20007870, FEBRA20043250, HCASM20003070, HHDPC20003150, NT2RI10000270, NT2RI20036950, NT2RI20053680, NT2RI20072540, NT2RI20083360, NT2RP70012310, NT2RP70030550, NT2RP70036470, OCBBF20013070, OCBBF20015270, PLACE60046630, PROST10003430, PROST20067370, SKMUS10001040, SKNMC20000970, SKNMC20015960, TESTI20030050, TESTI20032280, TESTI20033540, TESTI20035890, TESTI20068720, TRACH20004110
  • The 34 clones shown above are clones which were predicted to highly possibly belong to the category of DNA-binding and/or RNA-binding protein based on the result of domain search by Pfam.
  • NT2RI20064120
  • The clone shown above is a clone which was predicted to highly possibly belong to the category of ATP-binding and/or GTP-binding protein based on the result of domain search by Pfam.
  • The 178 clones shown below are clones which were unassignable to any of the above-mentioned categories, but have been predicted to have some functions based on homology search for their full-length nucleotide sequences and motif search in their deduced ORFs. Clone Name, Definition in the result of homology search or Motif Name in the motif search, demarcated by a double slash mark (//), are shown below.
  • 3NB6910001160//STEROIDOGENIC ACUTE REGULATORY PROTEIN PRECURSOR.
  • 3NB6910001290//KRAB box
  • 3NB6910001730//RI01/ZK632.3/MJ0444 family
  • 3NB6920014330//Domain of unknown function
  • ASTRO20000950//SNAP-25 family
  • BNGH410000030//R. norvegicus trg mRNA.
  • BNGH410000290//SPRY domain
  • BRACE20005250//DRR1 PROTEIN (TU3A PROTEIN).
  • BRACE20005650//ATP synthase ab C terminal
  • BRACE20013750//Hepatitis C virus non-structural protein NS4a
  • BRACE20014770//HUNTINGTIN ASSOCIATED PROTEIN 1 (HAP1).
  • BRACE20016730//Mus musculus mdgl-1 mRNA, complete cds.
  • BRACE20017370//P. vivax pva1 gene.
  • BRACE20019440//Protein of unknown function DUF82
  • BRACE20024310//P53-INDUCED PROTEIN 11.
  • BRACE20028960//Mus musculus mRNA for Ca2+ dependent activator protein for secretion, complete cds.
  • BRACE20077840//Putative Protein that mediates attachment of autophagosomes to microtubules, by similarity to yeast aut2 [Schizosaccharomyces pombe].
  • BRACE20093610//Bacterial type II secretion system protein
  • BRAWH20003230//Proline rich protein
  • BRAWH20009440//Arabidopsis thaliana pollenless3 (178) gene, complete cds;
  • beta-9 tubulin (TUB9) gene, partial cds; and unknown gene.
  • BRAWH20014610//TS-N domain//UBA domain
  • BRAWH20060440//PPR repeat
  • BRAWH20076050//LORICRIN.
  • CTONG20027210//VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13.
  • CTONG20028030//Domain of unknown function DUF19//Ribosomal protein S18
  • CTONG20064490//Drosophila melanogaster 26S proteasome regulatory complex subunit p42A mRNA, complete cds.
  • DFNES20004320//Homo sapiens ubiquitous TPR-motif protein Y isoform (UTY) gene, partial cds; alternatively spliced.
  • FCBBF10006870//Mus musculus Rap2 interacting protein 8 (RPIP8) mRNA, complete cds.
  • FCBBF20002320//T-box
  • FCBBF20002760//ALPHA SCRUIN.
  • FCBBF20012110//Leishmania major partial ppg1 gene for proteophosphoglycan.
  • FCBBF20016720//Domain of unknown function DUF94
  • FEBRA20000530//Drosophila melanogaster Diablo (dbo) mRNA, complete cds.
  • FEBRA20005360//Homo sapiens paraneoplastic cancer-testis-brain antigen (MA5) mRNA, complete cds.
  • FEBRA20007570//Homo sapiens BM-009 mRNA, complete cds.
  • FEBRA20011330//26S PROTEASOME REGULATORY SUBUNIT S3 (PROTEASOME SUBUNIT P58).
  • FEBRA20030540//Halocynthia roretzi mRNA for HrPET-1, complete cds.
  • FEBRA20044900//R. norvegicus mRNA for CPG2 protein.
  • FEBRA20048180//DRR1 PROTEIN (TU3A PROTEIN).
  • FEBRA20053800//Homo sapiens ubiquitous TPR-motif protein Y isoform (UTY) gene, partial cds; alternatively spliced.
  • FEBRA20057260//TBC domain
  • FEBRA20068730//Trg protein
  • HCASM10000210//Plasmodium berghei strain NYU2 merozoite surface protein-1 mRNA, partial cds.
  • HCASM20005360//Macrophage migration inhibitory factor
  • HEART20004110//POT family
  • HEART20005680//Nerve growth factor family
  • HHDPC20001150//Mus musculus putative secreted protein ZSIG37 (Zsig37) mRNA, complete cds.
  • HHDPC20001490//Mus musculus partial mRNA for muscle protein 534 (mg534 gene).
  • HHDPC20004560//2S seed storage family
  • HHDPC20004620//FAD binding domain
  • HSYRA10001190//PROBABLE GYP7 PROTEIN (FRAGMENT).
  • HSYRA10001780//Alpha-2-macroglobulin family N-terminal region
  • HSYRA20001350//CELL POLARITY PROTEIN TEA1.
  • HSYRA20014760//von Willebrand factor type A domain
  • HSYRA20016210//HesB-like domain
  • IMR3220002230//HINT PROTEIN (PROTEIN KINASE C INHIBITOR 1) (PKCI-1) (17 KD INHIBITOR OF PROTEIN KINASE C).
  • IMR3220014910//Rattus norvegicus tricarboxylate carrier-like protein mRNA, complete cds.
  • KIDNE10001520//Mus musculus yolk sac permease-like molecule 1 (YSPL-1) mRNA, complete cds.
  • KIDNE20003750//Mus musculus mRNA for granuphilin-a, complete cds.
  • KIDNE20005740//Staphylococcus epidermidis putative cell-surface adhesin SdrF (sdrF) gene, complete cds.
  • KIDNE20043440//Vacuolar protein sorting-associated protein—fission yeast
  • KIDNE20056760//NEURONAL PROTEIN.
  • KIDNE20060300//Gallus gallus syndesmos mRNA, complete cds.
  • KIDNE20062480//Scorpion short toxins
  • KIDNE20067750//Homo sapiens PTOV1 (PTOV1) gene, complete cds.
  • LIVER10000790//Rattus norvegicus fertility related protein WMP1 mRNA, complete cds.
  • MAMGL10000560//K-box region
  • MESAN10001010//Rat trg gene product
  • NB9N420004950//PROBABLE NUCLEAR ANTIGEN.
  • NT2NE10000180//SUPPRESSOR PROTEIN SRP40.
  • NT2NE10000630//Gallus gallus Dach2 protein (Dach2) mRNA, complete cds.
  • NT2NE20007630//Matrix protein (MA), p15
  • NT2NE20013370//Homo sapiens estrogen-responsive B box protein (EBBP) mRNA, complete cds.
  • NT2NE20016970//MSF1 PROTEIN.
  • NT2NE20035690//Homo sapiens phosphoinositol 3-phosphate-binding protein-2 (PEPP2) mRNA, complete cds.
  • NT2NE20053710//Ank repeat
  • NT2RI20006690//TRICHOHYALIN.
  • NT2RI20013420//Mus musculus cyclin ania-6b mRNA, partial cds.
  • NT2RI20013850//Homo sapiens P38IP (P381P) mRNA, complete cds.
  • NT2RI20015190//Homo sapiens misato mRNA, partial cds.
  • NT2RI20016210//Probable transposase—human transposon MER37
  • NT2RI20022700//X123 protein
  • NT2RI20025170//Homo sapiens PAR3 (PAR3) mRNA, complete cds.
  • NT2RI20029260//ARP2/3 COMPLEX 16 KDA SUBUNIT (P16-ARC).
  • NT2RI20029700//EF hand//EF hand
  • NT2RI20043040//Homo sapiens NY-REN-2 antigen mRNA, complete cds.
  • NT2RI20046060//K+ channel tetramerisation domain
  • NT2RI20061830//Proline-rich protein M14 precursor
  • NT2RI20065060//Drosophila melanogaster rudimentary gene, intron 3; anon-15AB gene, complete cds.
  • NT2RI20077230//Homo sapiens BRI3 mRNA, complete cds.
  • NT2RI20082210//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B) (SPR1B) (SPR1 B).
  • NT2RI20088120//AXONEME-ASSOCIATED PROTEIN MST101(2).
  • NT2RI20091440//SPRY domain
  • NT2RP60000080//Homo sapiens Pig11 (PIG11) mRNA, complete cds.
  • NT2RP60000720//Pinus taeda clone PtaAGP6 putative arabinogalactan protein mRNA, complete cds.
  • NT2RP70009060//Medicago truncatula mRNA for 85p protein (85p gene).
  • NT2RP70010800//Mus musculus mRNA for MILI (Miwi like), complete cds.
  • NT2RP70022430//Tax1-binding protein TRX—human.
  • NT2RP70028290//Scm-related gene containing four mbt domains [Mus musculus].
  • NT2RP70033040//YceA protein homolog ybfQ—Bacillus subtilis.
  • NT2RP70036320//Microfilarial sheath protein
  • NT2RP70039600//Calpain inhibitor repeat
  • NT2RP70042330//HYPOTHETICAL PROTEIN MJ0941.
  • NT2RP70049150//Mus musculus mRNA for UBE-1c1, UBE-1c2, UBE-1c3, complete cds.
  • NT2RP70052050//Human transformation-related protein mRNA, 3′ end.
  • NT2RP70084410//Polybromo 1 protein—chicken
  • NTONG10000520//Rattus norvegicus mRNA for Kelch related protein 1 (krp1 gene).
  • NTONG10001230//Mus msuculus mRNA, partial cds, clone CLFEST42.
  • OCBBF10001220//RING CANAL PROTEIN (KELCH PROTEIN).
  • OCBBF20010750//Spectrin repeat
  • OCBBF20011400//VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS8.
  • OCBBF20014020//Mus musculus NSD1 protein mRNA, complete cds.
  • PEBLM10001440//Trg
  • PEBLM20002130//Mus musculus genes for integrin aM290, hapsin, partial and complete cds.
  • PLACE50000370//Homo sapiens mRNA for hVPS11, complete cds.
  • PLACE60004290//Gag P30 core shell protein
  • PLACE60021020//Integrase Zinc binding domain//Integrase Zinc binding domain//DnaJ central domain (4 repeats)
  • PLACE60024190//TRICHOHYALIN.
  • PLACE60032040//Hirudin
  • PLACE60033990//SPIDROIN 1 (DRAGLINE SILK FIBROIN 1) (FRAGMENT).
  • PLACE60038500//Homo sapiens mitochondrial solute carrier mRNA, complete cds.
  • PLACE60043970//Takifugu rubripes retinitis pigmentosa GTPase regulator-like protein gene, partial cds.
  • PLACE60044640//Human placenta (Diff48) mRNA, complete cds.
  • PROST20023380//Cca3 protein
  • PROST20034720//IMMEDIATE-EARLY PROTEIN.
  • PROST20079740//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN CEX) (FRAGMENT).
  • SALGL10000050//Permeases for cytosine/purines, uracil, thiamine, allantoin
  • SALGL10000470//NG36 [Homo sappiens]
  • SKMUS20002710//Hepatitis C virus capsid protein
  • SKMUS20003650//Human (p23) mRNA, complete cds.
  • SKMUS20004580//Mus musculus N-RAP mRNA, complete cds.
  • SKMUS20009020//BRO1 PROTEIN.
  • SKMUS20009540//Homo sapiens F-box protein Fbx25 (FBX25) mRNA, partial cds.
  • SKMUS20010080//Mus musculus mRNA for a skeletal muscle and cardiac protein.
  • SKMUS20011470//Mus musculus RP42 mRNA, complete cds.
  • SKMUS20013640//Laminin EGF-like (Domains III and V)
  • SKMUS20015430//Homo sapiens HDCMC29P mRNA, partial cds.
  • SKNMC20010570//F-box domain.
  • SMINT20001450//Halocynthia roretzi mRNA for HrPET-3, complete cds.
  • SMINT20002270//Disintegrin//Trans-activation protein X
  • SMINT20003960//A kinase anchor protein AKAP-KL isoform 2
  • STOMA20002890//Adaptin N terminal region
  • SYNOV20002910//Arabinogalactan-like protein
  • SYNOV20008200//Trichoplusia ni transposon IFP2.
  • TESTI10000250//M. musculus mRNA for testis-specific protein, DDC8.
  • TESTI10000640//Fugu rubripes sex comb on midleg-like 2 protein (SCML2) gene, complete cds.
  • TESTI10001910//Homo sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds.
  • TESTI20000440//TRICHOHYALIN.
  • TESTI20002070//NIFU-LIKE PROTEIN.
  • TESTI20002080//Homo sapiens mRNA for Gab2, complete cds.
  • TESTI20014120//TRICHOHYALIN.
  • TESTI20016650//IMMEDIATE-EARLY PROTEIN.
  • TESTI20022230//Chlamydomonas reinhardtii strain 1132D-flagellar protofilament ribbon protein (RIB43a) mRNA, complete cds.
  • TESTI20022940//MOB2 PROTEIN (MPS1 BINDER 2).
  • TESTI20024610//TRICHOHYALIN.
  • TESTI20030590//TESTIS-SPECIFIC PROTEIN PBS13.
  • TESTI20030740//TRICHOHYALIN.
  • TESTI20031300//TPR Domain
  • TESTI20033560//F-box domain.
  • TESTI20035510//Proliferating-cell nucleolar antigen P120-like protein—Archaeoglobus fulgidus.
  • TESTI20035740//A-KINASE ANCHOR PROTEIN 150 (AKAP 150) (CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT II HIGH AFFINITY BINDING PROTEIN) (P150) (FRAGMENT).
  • TESTI20038940//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif
  • TESTI20040310//Protein of unknown function DUF84
  • TESTI20041220//Babesia bigemina 200 kDa antigen p200 mRNA, partial cds.
  • TESTI20052680//Rattus norvegicus RSD-6 mRNA, complete cds.
  • TESTI20054080//SER/THR-RICH PROTEIN T10 IN DGCR REGION.
  • TESTI20065720//PROTEIN D52 (N8 PROTEIN).
  • TESTI20078670//RING CANAL PROTEIN (KELCH PROTEIN).
  • TESTI20080330//Ribosomal protein L14p/L23e
  • TESTI20083430//TPR Domain
  • THYMU10000020//Homo sapiens mRNA for Golgi protein (GPP34 gene).
  • THYMU10002910//Homo sapiens AP-4 adaptor complex beta4 subunit mRNA, complete cds.
  • THYMU20002360//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain)
  • TRACH10000300//Anabaena PCC7120 hetC gene, complete cds.
  • TRACH20007800//Homo sapiens PTH-responsive osteosarcoma B1 protein (B1) mRNA, complete cds.
  • TRACH20008940//PROTEIN TSG24 (MEIOTIC CHECK POINT REGULATOR).
  • TRACH20013950//Homo sapiens NY-REN-25 antigen mRNA, partial cds.
  • UMVEN10001220//Corticotropin-releasing factor family
  • With respect to the remaining 476 clones, there are so far no information available for estimating their functions. However, there is the possibility that the functions of these clones will be revealed in future. Their Clone Names are indicated below.
  • 3NB6920013490, 3NB6920016370, 3NB6920017190, ADRGL10001820, ADRGL20004280, ASTRO20004800, BGGI110002850, BNGH410000130, BNGH410000170, BNGH410000330, BNGH410001530, BNGH420004740, BRACE10000200, BRACE10000700, BRACE10001590, BRACE20000770, BRACE20001000, BRACE20001410, BRACE20003320, BRACE20004210, BRACE20005050, BRACE20005450, BRACE20009880, BRACE20010700, BRACE20011880, BRACE20013740, BRACE20015430, BRACE20016920, BRACE20018650, BRACE20018980, BRACE20020500, BRACE20021510, BRACE20021760, BRACE20024950, BRACE20025900, BRACE20027520, BRACE20028600, BRACE20028610, BRACE20032850, BRACE20033190, BRACE20033980, BRACE20034310, BRACE20035160, BRACE20035270, BRACE20035390, BRACE20035940, BRACE20071530, BRACE20072010, BRACE20072320, BRACE20075270, BRACE20075630, BRACE20076210, BRACE20076460, BRACE20077080, BRACE20077270, BRACE20077670, BRACE20077680, BRACE20079020, BRACE20081140, BRACE20084800, BRACE20084880, BRACE20086530, BRACE20087080, BRACE20087540, BRACE20088570, BRACE20089990, BRACE20090140, BRACE20092740, BRACE20092750, BRACE20093110, BRACE20094370, BRACE20095170, BRAWH10000070, BRAWH10001740, BRAWH20000930, BRAWH20002480, BRAWH20005540, BRAWH20008660, BRAWH20008920, BRAWH20011030, BRAWH20047310, BRAWH20064930, BRAWH20069600, BRAWH20074060, BRAWH20089030, BRAWH20092270, BRAWH20094850, CTONG20003030, CTONG20007710, CTONG20008270, CTONG20020730, CTONG20021430, CTONG20024530, CTONG20029650, DFNES20002920, FCBBF10006860, FCBBF10006910, FCBBF10007320, FCBBF10007600, FCBBF20001050, FCBBF20001950, FCBBF20005760, FCBBF20006770, FCBBF20008080, FCBBF20012990, FCBBF20014800, FCBBF20017180, FCBBF20017200, FEBRA20003300, FEBRA20003910, FEBRA20006800, FEBRA20007400, FEBRA20007710, FEBRA20008740, FEBRA20009010, FEBRA20009590, FEBRA20011970, FEBRA20015900, FEBRA20015910, FEBRA20021940, FEBRA20027270, FEBRA20027830, FEBRA20028820, FEBRA20028970, FEBRA20029080, FEBRA20033080, FEBRA20042240, FEBRA20042370, FEBRA20042930, FEBRA20044120, FEBRA20044430, FEBRA20053770, FEBRA20054270, FEBRA20057520, FEBRA20059980, FEBRA20061500, FEBRA20063540, FEBRA20066270, FEBRA20074140, FEBRA20074580, FEBRA20076220, HCASM10001150, HCASM20005340, HLUNG10000300, HLUNG20003140, HLUNG20004120, HLUNG20004800, HLUNG20005010, HSYRA10001480, HSYRA20002480, HSYRA20002530, HSYRA20007600, HSYRA20011530, IMR3210000740, IMR3210000750, IMR3210001650, IMR3220006090, IMR3220009350, IMR3220009530, IMR3220011850, IMR3220016000, IMR3220017240, KIDNE10000280, KIDNE10000500, KIDNE10001450, KIDNE20001920, KIDNE20002440, KIDNE20002450, KIDNE20002660, KIDNE20033350, KIDNE20033770, KIDNE20037520, KIDNE20040340, KIDNE20040540, KIDNE20042940, KIDNE20045200, KIDNE20045340, KIDNE20045790, KIDNE20048640, KIDNE20048790, KIDNE20059370, KIDNE20070050, KIDNE20070770, KIDNE20073560, LIVER10000990, LIVER10002780, LIVER10003030, LIVER20004460, LIVER20005150, MAMGL10000350, MESAN20002670, MESAN20003370, NB9N410001210, NB9N410001460, NHNPC10001010, NT2NE10000040, NT2NE10001200, NT2NE20000380, NT2NE20000560, NT2NE20000640, NT2NE20006360, NT2NE20007060, NT2NE20007870, NT2NE20008020, NT2NE20009800, NT2NE20011560, NT2NE20013240, NT2NE20013640, NT2NE20014030, NT2NE20014280, NT2NE20015300, NT2NE20016230, NT2NE20016480, NT2NE20044900, NT2RI10000160, NT2RI10001640, NT2RI20000640, NT2RI20002700, NT2RI20002940, NT2RI20006710, NT2RI20007380, NT2RI20008650, NT2RI20012350, NT2RI20012440, NT2RI20014100, NT2RI20017260, NT2RI20026540, NT2RI20028020, NT2RI20028520, NT2RI20030190, NT2RI20030670, NT2RI20033040, NT2RI20033380, NT2RI20035560, NT2RI20040590, NT2RI20043980, NT2RI20047830, NT2RI20048400, NT2RI20049160, NT2RI20049840, NT2RI20056280, NT2RI20061270, NT2RI20063450, NT2RI20064870, NT2RI20065530, NT2RI20066670, NT2RI20067880, NT2RI20071160, NT2RI20072140, NT2RI20073860, NT2RI20075070, NT2RI20075720, NT2RI20075890, NT2RI20077290, NT2RI20077510, NT2RI20085260, NT2RI20086560, NT2RI20088010, NT2RI20090830, NT2RP60000170, NT2RP60000590, NT2RP70000410, NT2RP70003910, NT2RP70005790, NT2RP70013350, NT2RP70024490, NT2RP70025540, NT2RP70028410, NT2RP70030500, NT2RP70030910, NT2RP70047510, NT2RP70047660, NT2RP70049750, NT2RP70052190, NT2RP70054680, NT2RP70054930, NT2RP70063740, NT2RP70066210, NT2RP70067010, NT2RP70069800, NT2RP70071140, NT2RP70073590, NT2RP70079300, NT2RP70081420, NT2RP70086230, NT2RP70092150, NT2RP70092590, NT2RP70093630, NT2RP70093970, NT2RP70094660, NT2RP70095020, NTONG10000330, NTONG20005830, NTONG20009850, NTONG20011370, NTONG20014280, OCBBF10000670, OCBBF10000860, OCBBF10001040, OCBBF20000130, OCBBF20001260, OCBBF20002870, OCBBF20009040, OCBBF20017060, PANCR10001850, PEBLM10000290, PEBLM10001800, PEBLM20000300, PEBLM20001260, PEBLM20001470, PLACE50001530, PLACE60000440, PLACE60000700, PLACE60000800, PLACE60001370, PLACE60002630, PLACE60003710, PLACE60004240, PLACE60005230, PLACE60005500, PLACE60009530, PLACE60012940, PLACE60019230, PLACE60019250, PLACE60026920, PLACE60029490, PLACE60030940, PLACE60031090, PLACE60033720, PLACE60037400, PLACE60040050, PLACE60043120, PLACE60043360, PLACE60044910, PLACE60046870, PLACE60049310, PROST10001520, PROST10002460, PROST10005640, PROST20002060, PROST20002670, PROST20002740, PROST20004630, PROST20017390, PROST20017960, PROST20019980, PROST20021620, PROST20025910, PROST20028420, PROST20031020, PROST20032100, PROST20033030, PROST20037320, PROST20044810, PROST20056040, PROST20061960, PUAEN10000810, SKMUS10001240, SKMUS20003430, SKMUS20004670, SKMUS20004680, SKMUS20008470, SKMUS20009450, SKMUS20015010, SKMUS20016080, SKMUS20016310, SKMUS20016710, SKNMC10000070, SKNMC10000100, SKNMC10001100, SKNMC10001590, SKNMC10001680, SKNMC10002640, SKNMC20003050, SKNMC20005930, SKNMC20006120, SKNMC20015550, SKNSH10000860, SKNSH10003080, SKNSH20001510, SKNSH20001630, SMINT10000390, SMINT10000540, SMINT20000400, SMINT20002390, SMINT20005580, SPLEN10000490, SPLEN20000470, SPLEN20002420, SPLEN20004430, SPLEN20005410, STOMA10000470, STOMA10001330, STOMA20001880, STOMA20004780, SYNOV10001640, SYNOV20011440, SYNOV20014570, TESTI10000230, TESTI10001250, TESTI10001630, TESTI10001790, TESTI20000180, TESTI20001790, TESTI20003720, TESTI20004620, TESTI20005200, TESTI20006710, TESTI20008190, TESTI20008300, TESTI20009510, TESTI20010080, TESTI20010820, TESTI20013060, TESTI20015930, TESTI20017580, TESTI20017660, TESTI20017920, TESTI20018260, TESTI20018290, TESTI20018980, TESTI20019500, TESTI20019680, TESTI20019910, TESTI20020480, TESTI20020900, TESTI20022450, TESTI20022640, TESTI20023610, TESTI20023690, TESTI20024150, TESTI20025440, TESTI20028060, TESTI20028400, TESTI20029650, TESTI20032550, TESTI20032800, TESTI20032990, TESTI20033760, TESTI20034180, TESTI20035410, TESTI20035800, TESTI20037270, TESTI20041110, TESTI20042430, TESTI20049290, TESTI20051550, TESTI20054920, TESTI20062380, TESTI20062550, TESTI20064250, TESTI20069790, TESTI20073580, TESTI20074020, TESTI20076130, TESTI20077500, TESTI20081390, TESTI20082340, TESTI20082400, TESTI20084400, THYMU10000320, THYMU10001050, THYMU10003660, THYMU10004730, THYMU10005270, THYMU20001400, TRACH10000180, TRACH10000570, TRACH10001060, TRACH20002350, TRACH20004610, TRACH20011920, TRACH20014000, UTERU20003380, UTERU20005410, UTERU20005690
    • EXAMPLE 7 Expression Frequency Analysis In Silico
  • The cDNA libraries derived from various tissues and cells as indicated in Example 1 were prepared, and cDNA clones were selected from each library at random. The 5′-end sequences were determined and the database was constructed based on the data. The database was constructed based on the nucleotide sequences of 770,546 clones, and thus the population of the database is large enough for the analysis.
  • Then, clones having a homologous sequence are categorized into a single cluster (clustering) by searching the nucleotide sequences of respective clones in this database with the program of nucleotide sequence homology search; the number of clones belonging to each cluster was determined and normalized for every library; thus, the ratio of a certain gene in each cDNA library was determined. This analysis gave the information of the expression frequency of genes in tissues and cells which were sources of the cDNA libraries.
  • Then, in order to analyze the expression of a gene containing the nucleotide sequence of the cDNA of the present invention in tissues and cells, the library derived from a tissue or a cell used in the large-scale cDNA analysis was subjected to the comparison of the expression levels between tissues or cells. Namely, the expression frequency was analyzed by comparing the previously normalized values between tissues and/or cells for which the nucleotide sequences of 600 or more cDNA clones had been analyzed. By this analysis, some of the genes were revealed to be involved in the pathology and functions indicated below. Each value in Tables 3 to 39 shown below represents a relative expression frequency; the higher the value, the higher the expression level.
  • Osteoporosis-Related Genes
  • Osteoporosis is a pathology in which bones are easily broken owing to overall decrease in components of bone. The onset involves the balance between the functions of osteoblast producing bone and osteoclast absorbing bone, namely bone metabolism. Thus, the genes involved in the increase of osteoclasts differentiating from precursor cells of monocyte/macrophage line (Molecular Medicine 38. 642-648. (2001)) are genes involved in bone metabolism associated with osteoporosis.
  • A nucleotide sequence information-based analysis was carried out to identify the genes whose expression frequencies are higher or lower in CD34+ cell (cell expressing a glycoprotein CD34) treated with the osteoclast differentiation factor (Molecular Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell, which is the precursor cell of monocyte/macrophage line. The result of comparative analysis for the frequency between the two cDNA libraries prepared from the RNA of CD34+ cells (CD34C) and from the RNA of CD34+ cells treated with the osteoclast differentiation factor (D30ST, D60ST or D90ST) showed that the genes whose expression levels were different between the two were the following clones (Table 3).
  • KIDNE20062480, NT2RI20016570, PLACE60020840, 3NB6920002810, BRACE20035270, BRAWH20000340, FEBRA20062700, HSYRA20011030, NT2RP70030910, OCBBF20011240, PLACE60043120, SYNOV20011440, HCASM10001150, IMR3220016000, NT2RI20082210, D3OST20001840, FEBRA20012940, FEBRA20021910, IMR3220002230, IMR3220012180, NT2RI20000640, NT2RI20010910, NT2RI20058110, NT2RP60000350, NT2RP70011660, PEBLM20003950, PLACE60049310, PROST20062600, TESTI20007840, TESTI20040310, TESTI20080200, THYMU10003590, TRACH10000630, TRACH20007800, CD34C20000510, HSYRA20016210, KIDNE20004030, KIDNE20073280, NT2RP70055020, PLACE60043960, SKMUS10000220
  • These genes are involved in osteoporosis.
  • Genes Involved in Neural Cell Differentiation
  • Genes involved in neural cell differentiation are useful for treating neurological diseases. Genes with varying expression levels in response to induction of cellular differentiation in neural cells are thought to be involved in neurological diseases.
  • A survey was performed for genes whose expression levels are varied in response to induction of differentiation (stimulation by retinoic acid (RA) or growth inhibitor treatment after RA stimulation) in cultured cells of a neural strain, NT2. The result of comparative analysis of cDNA libraries derived from undifferentiated NT2 cells (NT2RM) and the cells subjected to the differentiation treatment (NT2RP, NT2RI or NT2NE) showed that the genes whose expression levels were different between the two were the following clones (Table 4).
  • SKNMC20000970, 3NB6920009120, BRAWH20006970, KIDNE20062480, NHNPC20002060, NT2NE20053710, NT2RI20000640, NT2RI20004210, NT2RI20006710, NT2RI20009740, NT2RI20013420, NT2RI20013850, NT2RI20014100, NT2RI20025410, NT2RI20033040, NT2RI20035560, NT2RI20036950, NT2RI20051500, NT2RI20053350, NT2RI20057230, NT2RI20071330, NT2RI20075720, NT2RI20083960, NT2RI20087910, NT2RI20090650, NT2RI20094060, NT2RP60000350, NT2RP70000760, NT2RP70036800, NT2RP70071770, NT2RP70074220, TESTI20007840, TESTI20080200, 3NB6920002810, 3NB6920005450, HSYRA20015740, HSYRA20016210, IMR3220016000, KIDNE20060140, NT2RI20014490, NT2RI20015950, NT2RI20022520, NT2RI20025170, NT2RI20025540, NT2RI20030510, NT2RI20040590, NT2RI20046060, NT2RI20053680, NT2RI20058510, NT2RI20066820, NT2RI20067030, NT2RI20074980, NT2RI20075890, NT2RI20078840, NT2RI20084810, NT2RI20089420, NT2RP70002380, NT2RP70023790, NT2RP70029820, NT2RP70049150, NT2RP70055020, NT2RP70065270, NT2RP70069860, NT2RP70075370, NT2RP70079750, NT2RP70092590, OCBBF20000130, PLACE60043970, TESTI20053960, BNGH420004740, HSYRA20002480, NT2NE10000730, NT2NE20000560, NT2NE20003270, NT2NE20008090, NT2NE20014030, NT2RP60000720, NT2RP60001090, NT2RP70004770, NT2RP70010800, NT2RP70011660, NT2RP70028750, NT2RP70029060, NT2RP70030550, NT2RP70032030, NT2RP70036320, NT2RP70064900, NT2RP70093220, NT2RP70093730, SYNOV20013740, TESTI20021490, TRACH20004720, TRACH20007800, 3NB6920003300, BRACE10000200, BRACE20018550, FEBRA20008740, FEBRA20074580, FEBRA20076220, KIDNE20073520, MAMGL10000320, NT2NE20002140, NT2NE20006360, NT2NE20007870, NT2NE20009800, NT2NE20035690, NT2RI20002940, NT2RI20014500, NT2RI20016210, NT2RI20029260, NT2RI20037510, NT2RI20055640, NT2RI20064120, NT2RI20074390, NT2RI20077230, NT2RI20090660, PLACE60040050, TRACH20012890, 3NB6910001730, BRACE10001150, BRACE20011170, BRACE20020910, BRACE20035270, BRAWH20005220, FEBRA20003970, FEBRA20012450, HLUNG20003140, IMR3220009350, IMR3220013170, IMR3220013320, IMR3220014350, NT2NE10000040, NT2NE10000140, NT2NE10000180, NT2NE10000230, NT2NE10000630, NT2NE10000830, NT2NE10001200, NT2NE10001630, NT2NE10001850, NT2NE20000380, NT2NE20000640, NT2NE20001740, NT2NE20002590, NT2NE20002990, NT2NE20003690, NT2NE20003840, NT2NE20003920, NT2NE20004550, NT2NE20004700, NT2NE20005170, NT2NE20005360, NT2NE20005500, NT2NE20005860, NT2NE20006580, NT2NE20007060, NT2NE20007630, NT2NE20008020, NT2NE20011560, NT2NE20012470, NT2NE20013240, NT2NE20013370, NT2NE20013640, NT2NE20013720, NT2NE20014280, NT2NE20014350, NT2NE20015300, NT2NE20016230, NT2NE20016260, NT2NE20016340, NT2NE20016480, NT2NE20016660, NT2NE20016970, NT2NE20034080, NT2NE20044900, NT2NE20047160, NT2NE20054410, NT2NE20055170, NT2NE20057200, OCBBF20009040, OCBBF20015860, PLACE60020840, PROST10005260, SKMUS20008630, SMINT20003960, STOMA20001210, SYNOV20011440, TESTI10000230, TESTI20009700, TESTI20040310, THYMU10003290, TRACH20013950, BGGI120010970, BNGH410001980, BRACE10001660, BRACE20014770, BRACE20034490, BRACE20071740, BRAWH20009440, BRAWH20036930, CTONG20020730, CTONG20028030, FCBBF10006750, FCBBF20012110, FCBBF20015380, FEBRA20007570, FEBRA20043250, FEBRA20068730, HCASM10001150, HCASM20002140, HHDPC20000950, HHDPC20004620, HSYRA10001370, HSYRA10001780, HSYRA20001350, HSYRA20006050, IMR3210001580, IMR3220002230, IMR3220003020, KIDNE20004030, KIDNE20060300, KIDNE20073280, MESAN20005010, NT2RI10000160, NT2RI10000270, NT2RI10000480, NT2RI10001640, NT2RI20002700, NT2RI20002820, NT2RI20003410, NT2RI20004120, NT2RI20005970, NT2RI20006690, NT2RI20006850, NT2RI20007380, NT2RI20008650, NT2RI20010100, NT2RI20010830, NT2RI20010910, NT2RI20012350, NT2RI20012440, NT2RI20014090, NT2RI20015190, NT2RI20015400, NT2RI20016570, NT2RI20017260, NT2RI20018460, NT2RI20018660, NT2RI20020220, NT2RI20020410, NT2RI20021520, NT2RI20022430, NT2RI20022700, NT2RI20025300, NT2RI20025850, NT2RI20026540, NT2RI20028020, NT2RI20028520, NT2RI20029580, NT2RI20029700, NT2RI20030110, NT2RI20030190, NT2RI20030670, NT2RI20031540, NT2RI20032050, NT2RI20032220, NT2RI20033010, NT2RI20033380, NT2RI20033440, NT2RI20033830, NT2RI20036780, NT2RI20041900, NT2RI20042840, NT2RI20043040, NT2RI20043980, NT2RI20044420, NT2RI20047830, NT2RI20048400, NT2RI20049160, NT2RI20049840, NT2RI20049850, NT2RI20050610, NT2RI20050870, NT2RI20056280, NT2RI20056470, NT2RI20058110, NT2RI20060710, NT2RI20060720, NT2RI20061270, NT2RI20061830, NT2RI20062100, NT2RI20063450, NT2RI20064870, NT2RI20065060, NT2RI20065530, NT2RI20066670, NT2RI20066790, NT2RI20067350, NT2RI20067880, NT2RI20068250, NT2RI20068550, NT2RI20070480, NT2RI20070840, NT2RI20070960, NT2RI20071160, NT2RI20071480, NT2RI20072140, NT2RI20072540, NT2RI20073030, NT2RI20073840, NT2RI20073860, NT2RI20074690, NT2RI20075070, NT2RI20077290, NT2RI20077510, NT2RI20077540, NT2RI20078270, NT2RI20078790, NT2RI20078910, NT2RI20080500, NT2RI20081880, NT2RI20082210, NT2RI20083360, NT2RI20085260, NT2RI20085980, NT2RI20086560, NT2RI20087140, NT2RI20087490, NT2RI20088010, NT2RI20088120, NT2RI20090830, NT2RI20091440, NT2RI2009215-0, NT2RI20092890, NTONG10001820, OCBBF20002770, OCBBF20011240, PEBLM10001440, PLACE50001130, PLACE60014430, PROST20029600, PUAEN10000570, SALGL10001570, SKMUS10000220, SKMUS20004670, STOMA20002890, SYNOV10001280, TESTI20012690, TESTI20023690, TESTI20028660, TESTI20068720, THYMU10000020, THYMU10000830, TRACH20002370, 3NB6910001290, BRACE10000700, BRACE20003320, BRACE20015080, BRACE20079020, BRACE20083800, BRACE20092740, FEBRA20008810, FEBRA20017150, FEBRA20067930, HHDPC20000550, HSYRA20008280, HSYRA20014760, KIDNE10001450, KIDNE20000850, KIDNE20002660, KIDNE20003300, KIDNE20033050, KIDNE20045340, NT2RP60000080, NT2RP60000170, NT2RP60000320, NT2RP60000390, NT2RP60000590, NT2RP60000860, NT2RP60001000, NT2RP60001230, NT2RP60001270, NT2RP70000410, NT2RP70000690, NT2RP70002590, NT2RP70002710, NT2RP70003640, NT2RP70003910, NT2RP70004250, NT2RP70005790, NT2RP70006240, NT2RP70008120, NT2RP70009060, NT2RP70012310, NT2RP70013060, NT2RP70013350, NT2RP70015910, NT2RP70018560, NT2RP70021510, NT2RP70022430, NT2RP70023760, NT2RP70024490, NT2RP70024500, NT2RP70025540, NT2RP70026190, NT2RP70028290, NT2RP70028410, NT2RP70030500, NT2RP70030910, NT2RP70033040, NT2RP70036290, NT2RP70036470, NT2RP70039600, NT2RP70040800, NT2RP70042040, NT2RP70042330, NT2RP70042600, NT2RP70043730, NT2RP70043960, NT2RP70045410, NT2RP70046560, NT2RP70046870, NT2RP70047510, NT2RP70047660, NT2RP70047900, NT2RP70049250, NT2RP70049750, NT2RP70052050, NT2RP70052190, NT2RP70054680, NT2RP70054930, NT2RP70055130, NT2RP70055200, NT2RP70061620, NT2RP70061880, NT2RP70062960, NT2RP70063040, NT2RP70063740, NT2RP70064080, NT2RP70066210, NT2RP70067010, NT2RP70069800, NT2RP70071140, NT2RP70071540, NT2RP70072210, NT2RP70072520, NT2RP70073590, NT2RP70073810, NT2RP7.0074060, NT2RP70075040, NT2RP70076100, NT2RP70076170, NT2RP70076430, NT2RP70079250, NT2RP70079300, NT2RP70081330, NT2RP70081370, NT2RP70081420, NT2RP70081440, NT2RP70081670, NT2RP70083150, NT2RP70084060, NT2RP70084410, NT2RP70084870, NT2RP70085500, NT2RP70085570, NT2RP70086230, NT2RP70087200, NT2RP70088550, NT2RP70090120, NT2RP70090190, NT2RP70091490, NT2RP70091680, NT2RP70092150, NT2RP70092360, NT2RP70093630, NT2RP70093700, NT2RP70093940, NT2RP70093970, NT2RP70094290, NT2RP70094660, NT2RP70094810, NT2RP70094980, NT2RP70095020, NT2RP70095070, NTONG10000980, NTONG10002140, NTONG20002650, NTONG20016120, PEBLM20003950, PROST10005640, PROST20003250, SKNMC20000650, SKNSH10000860, SKNSH20003470, TESTI10000510, TESTI10000960, TESTI20015110, TESTI20074640, TRACH20004610
  • These genes are neurological disease-related genes.
  • Cancer-Related Genes
  • It has been assumed that, distinct from normal tissues, cancer tissues express a distinct set of genes, and thus the expression can contribute to the carcinogenesis in tissues and cells. Thus, the genes whose expression patterns in cancer tissues are different from those in normal tissues are cancer-related genes. Search was carried out for the genes whose expression levels in cancer tissues were different from those in normal tissues.
  • The result of comparative analysis of cDNA libraries derived from breast tumor (TBAES) and normal breast (BEAST) showed that the genes whose expression levels were different between the two were the following clones (Table 5).
  • 3NB6910001730, FCBBF10007600, KIDNE20033050, KIDNE20060300, NT2RI20065530, NT2RP60000720, NT2RP70075370, TRACH20004200, LIVER10000670, LIVER10005420, LIVER20000370
  • The result of comparative analysis of cDNA libraries derived cervical tumor (TCERX) and normal cervical duct (CERVX) showed that the genes whose expression levels were different between the two were the following clones (Table 6).
  • BRACE10001590, HHDPC20000950, HSYRA20016210, NT2RI20074980, 3NB6920014330, NT2RI20087490, NT2RP60001090, PROST10002200, SKNMC20003220, STOMA20001210
  • The result of comparative analysis of cDNA libraries derived from colon tumor (TCOLN) and normal colon (COLON) showed that the genes whose expression levels were different between the two were the following clones (Table 7).
  • BRACE20028610, BRACE20011170, BRACE20035940, IMR3220013320, NT2NE20053710
  • The result of comparative analysis of cDNA libraries derived from esophageal tumor (TESOP) and normal esophagus (NESOP) showed that the genes whose expression levels were different between the two were the following clones (Table 8).
  • KIDNE20005740, MAMGL10000320, NESOP10000870, NT2RI20056470, NTONG20008000
  • The result of comparative analysis of cDNA libraries derived from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the genes whose expression levels were different between the two were the following clones (Table 9).
  • 3NB6920002810, ADRGL10000020, BNGH420004740, BRACE10000200, BRACE10000420, BRACE10000730, BRACE10001590, BRACE20005650, BRACE20016730, BRACE20028120, BRACE20077980, BRACE20083800, BRACE20083850, BRAWH10001740, BRAWH20036930, BRAWH20064500, BRAWH20064930, CTONG20028030, FCBBF20015380, FEBRA20005360, FEBRA20007570, FEBRA20008740, FEBRA20012270, FEBRA20025250, HSYRA20002480, HSYRA20006400, HSYRA20008280, HSYRA20015740, HSYRA20016210, IMR3220009350, LIVER10001110, NT2NE20003920, NT2NE20007630, NT2NE20007870, NT2RI20025410, NT2RI20026540, NT2RI20029580, NT2RI20033380, NT2RI20033830, NT2RI20051500, NT2RI20058110, NT2RI20090650, NT2RP60000720, NT2RP70013350, NT2RP70023790, NT2RP70024490, NT2RP70028750, NT2RP70029060, NT2RP70036800, NT2RP70075370, NT2RP70076100, NTONG10000980, NTONG10002460, NTONG20015500, OCBBF20002310, OCBBF20013070, PEBLM20001470, PEBLM20003950, PLACE60021510, PLACE60040050, PLACE60043970, PROST20051430, STOMA20001210, STOMA20002570, STOMA20002890, SYNOV20011440, TESTI10000230, TESTI20009700, TESTI20021490, TESTI20032800, TESTI20053960, TESTI20080200, TESTI20082400, BGGI120010970, BRACE20004210, BRACE20005250, BRACE20011170, BRACE20020910, BRACE20080970, BRAWH20000340, BRAWH20006970, BRAWH20011660, FCBBF20001950, FEBRA20043250, HLUNG10000640, IMR3220007420, IMR3220014350, KIDNE10000080, KIDNE10000280, KIDNE10000500, KIDNE10001040, KIDNE10001430, KIDNE10001450, KIDNE10001520, KIDNE20000410, KIDNE20000510, KIDNE20000700, KIDNE20000850, KIDNE20001670, KIDNE20001920, KIDNE20002440, KIDNE20002450, KIDNE20002660, KIDNE20003150, KIDNE20003300, KIDNE20003490, KIDNE20003750, KIDNE20004030, KIDNE20004220, KIDNE20004970, KIDNE20005130, KIDNE20005170, KIDNE20005190, KIDNE20005740, KIDNE20031850, KIDNE20033050, KIDNE20033350, KIDNE20033570, KIDNE20033730, KIDNE20033770, KIDNE20037520, KIDNE20039410, KIDNE20039940, KIDNE20040340, KIDNE20040540, KIDNE20040840, KIDNE20042620, KIDNE20042940, KIDNE20042950, KIDNE20043440, KIDNE20044110, KIDNE20045200, KIDNE20045340, KIDNE20045790, KIDNE20046810, KIDNE20048280, KIDNE20048640, KIDNE20048790, KIDNE20049810, KIDNE20050420, KIDNE20052960, KIDNE20053360, KIDNE20054000, KIDNE20054770, KIDNE20056290, KIDNE20056760, KIDNE20059080, KIDNE20059370, KIDNE20060140, KIDNE20060300, KIDNE20060530, KIDNE20060620, KIDNE20061490, KIDNE20062990, KIDNE20063530, KIDNE20063760, KIDNE20066520, KIDNE20067600, KIDNE20067750, KIDNE20068800, KIDNE20070050, KIDNE20070770, KIDNE20071860, KIDNE20073280, KIDNE20073520, KIDNE20073560, KIDNE20074220, KIDNE20075690, KIDNE20078100, KIDNE20078110, LIVER10000790, MAMGL10000320, NB9N410000470, NT2NE20053710, NT2RI20006710, NT2RI20013420, NT2RI20016570, NT2RI20018460, NT2RI20025540, NT2RI20040590, NT2RI20065530, NT2RI20087490, NT2RI20087910, NT2RP60000350, NT2RP60001230, NT2RP70043730, NT2RP70069860, NT2RP70074220, OCBBF20014940, PLACE60020840, PLACE60043120, PROST10003430, SKNSH20001510, SMINT10000160, SPLEN20000470, SPLEN20001340, SPLEN20003570, STOMA10000470, TESTI10000700, TESTI20027070, TESTI20040310, TRACH10000300, TRACH20000790, TRACH20002500, TRACH20007800
  • The result of comparative analysis of cDNA libraries derived from liver tumor (TLIVE) and normal liver (LIVER) showed that the genes whose expression levels were different between the two were the following clones (Table 10).
  • FCBBF50002610, FEBRA20076220, KIDNE20033050, NT2NE20003840, KIDNE20062480, KIDNE20068800, LIVER10000580, LIVER10000670, LIVER10000790, LIVER10000990, LIVER10001040, LIVER10001110, LIVER10001750, LIVER10002300, LIVER10002780, LIVER10003030, LIVER10004330, LIVER10005420, LIVER20000330, LIVER20004160, LIVER20004460, LIVER20005150, NT2NE20002140, NT2RI20030510, NT2RI20043040, NT2RI20090650, PROST10005640, PROST20032320, SALGL10001570, SMINT10000160, SPLEN20002420, TESTI20002530, TESTI20080200, THYMU10003590, TRACH20004720
  • The result of comparative analysis of cDNA libraries derived from lung tumor (TLUNG) and normal lung (HLUNG) showed that the genes whose expression levels were different between the two were the following clones (Table 11).
  • NT2RI20030110, BNGH410001980, BRACE10000420, BRACE10001150, BRACE20014770, BRACE20018550, BRAWH20006970, BRAWH20014610, FEBRA20008810, FEBRA20015840, FEBRA20044120, HHDPC20001490, HLUNG10000240, HLUNG1000300, HLUNG10000370, HLUNG10000640, HLUNG10000760, HLUNG10000990, HLUNG10001050, HLUNG10001100, HLUNG20000680, HLUNG20001160, HLUNG20001250, HLUNG20001420, HLUNG20001760, HLUNG20002550, HLUNG20003140, HLUNG20004120, HLUNG20004800, HLUNG20005010, HSYRA20014200, KIDNE20002660, KIDNE20033050, NT2NE20014350, NT2RI20016570, NT2RI20026540, NT2RI20051500, NT2RI20064120, NT2RI20083960, NT2RI20085260, NT2RI20087490, NT2RP70009060, NT2RP70011660, NT2RP70029060, NT2RP70055020, NT2RP70074220, NT2RP70076100, NTONG10002460, NTONG20008000, PLACE60043120, SKMUS20016340, SKNMC20005930, SMINT20000180, SMINT20002390, SMINT20002770, SMINT20003960, STOMA10000470, STOMA20001880, SYNOV20013740, TESTI20036250, TESTI20080200, TRACH20004610
  • The result of comparative analysis of cDNA libraries derived from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes whose expression levels were different between the two were the following clones (Table 12).
  • BRACE20011880, TESTI20030710, BRACE20076210, NT2RI20053680, SKMUS20008630, TESTI20005910, TESTI20040310
  • The result of comparative analysis of cDNA libraries derived from stomach tumor (TSTOM) and normal stomach (STOMA) showed that the genes whose expression levels were different between the two were the following clones (Table 13).
  • HSYRA20011030, NT2RI20013420, NT2RP70079750, BRACE20003320, HEART20005060, HHDPC20000950, HLUNG20004120, HLUNG20005010, HSYRA20006400, KIDNE10000500, KIDNE20062480, NT2NE20053710, NT2NE20054410, NT2RI20015400, NT2RI20016570, NT2RI20064120, NT2RI20070840, NT2RI20071330, NT2RI20074980, NT2RI20077230, NT2RI20089420, NT2RP70000760, NT2RP70028750, PLACE60014430, PLACE60024190, SKNMC20000970, STOMA10000470, STOMA10000520, STOMA10001170, STOMA10001330, STOMA10001860, STOMA20000320, STOMA20000880, STOMA20001210, STOMA20001880, STOMA20002570, STOMA20002890, STOMA20003960, STOMA20004780, STOMA20004820, THYMU10003590
  • The result of comparative analysis of cDNA libraries derived from uterine tumor (TUTER) and normal uterus (UTERU) showed that the genes whose expression levels were different between the two were the following clones (Table 14).
  • NT2RI20085260, 3NB6920002810, BRACE10000420, BRACE20089990, BRACE20092120, BRAWH10001680, BRAWH20011410, BRAWH20011660, FCBBF20005910, FCBBF50002610, FEBRA20005360, FEBRA20006800, FEBRA20008800, FEBRA20044120, FEBRA20057520, HEART20005060, HHDPC20000950, HLUNG10000760, HLUNG20003140, HSYRA20014200, HSYRA20014760, HSYRA20015800, IMR3210002420, IMR3220002230, IMR3220009350, IMR3220014350, IMR3220016000, KIDNE20000850, KIDNE20060140, KIDNE20060300, MAMGL10000350, NT2NE20035690, NT2NE20053710, NT2RI10000270, NT2RI20000640, NT2RI20002940, NT2RI20010910, NT2RI20013420, NT2RI20016570, NT2RI20033380, NT2RI20036950, NT2RI20037510, NT2RI20053350, NT2RI20057230, NT2RI20058110, NT2RI20071480, NT2RI20074980, NT2RI20084810, NT2RI20087490, NT2RI20087910, NT2RP60000350, NT2RP70032030, NT2RP70043730, NTONG10000980, NTONG10002460, PLACE60014430, PLACE60026680, PLACE60043960, PLACE60044910, PLACE60047380, PROST10002200, PROST10005260, PROST20025910, PROST20033380, PUAEN10000570, SALGL10001570, SKMUS10000140, SKMUS20003430, SKMUS20009540, SKNMC10002510, SKNMC20000970, SKNSH10000860, SMINT20002770, STOMA20002890, SYNOV20011440, TESTI10000230, TESTI20018290, TESTI20021490, TESTI20080200, TESTI20082400, TRACH10000300, TRACH20002370, TRACH20007800, TRACH20012890, UTERU10000770, UTERU10000960, UTERU10001600, UTERU10001920, UTERU20000470, UTERU20003380, UTERU20003930, UTERU20004850, UTERU20005410, UTERU20005690
  • The result of comparative analysis of cDNA libraries derived from tongue cancer (CTONG) and normal tongue (NTONG) showed that the genes whose expression levels were different between the two were the following clones (Table 15).
  • 3NB6910001160, 3NB6910001290, 3NB6910001730, BNGH420004740, BRACE20008850, BRACE20020910, BRACE20074010, BRAWH20014840, BRAWH20089560, CTONG20003030, CTONG20005890, CTONG20007710, CTONG20008270, CTONG20011390, CTONG20013200, CTONG20013660, CTONG20015330, CTONG20018200, CTONG20019110, CTONG20019550, CTONG20020730, CTONG20021430, CTONG20024180, CTONG20024530, CTONG20025580, CTONG20027210, CTONG20028030, CTONG20028160, CTONG20028200, CTONG20029650, CTONG20037820, CTONG20047160, CTONG20055530, CTONG20064490, FEBRA20003770, FEBRA20004520, FEBRA20007400, FEBRA20007570, FEBRA20012940, FEBRA20021940, FEBRA20044120, HCASM10001150, HHDPC20004560, HLUNG20003140, HSYRA20002480, IMR3220009350, IMR3220012180, KIDNE20000850, KIDNE20002660, KIDNE20004220, KIDNE20005740, KIDNE20056760, KIDNE20060140, KIDNE20062480, MESAN20000920, MESAN20003370, NHNPC20002060, NT2NE10001850, NT2NE20000560, NT2NE20002140, NT2NE20003270, NT2NE20003840, NT2NE20014350, NT2NE20053710, NT2RI20006690, NT2RI20006710, NT2RI20016570, NT2RI20018660, NT2RI20025300, NT2RI20025410, NT2RI20030190, NT2RI20030510, NT2RI20036950, NT2RI20046060, NT2RI20053350, NT2RI20067350, NT2RI20075720, NT2RI20078790, NT2RI20083960, NT2RI20087140, NT2RI20094060, NT2RP60000350, NT2RP60001230, NT2RP70000760, NT2RP70004770, NT2RP70009060, NT2RP70011660, NT2RP70023760, NT2RP70023790, NT2RP70024500, NT2RP70026190, NT2RP70029820, NT2RP70036470, NT2RP70043730, NT2RP70061880, NT2RP70071770, NT2RP70076100, NT2RP70079750, NT2RP70084870, NT2RP70093730, OCBBF20013070, PEBLM20003950, PLACE60037450, PLACE60043120, PROST10003430, PROST10005260, PROST20032320, PROST20033020, PROST20056040, SKNMC10002510, SKNMC20000650, SKNMC20010570, SKNSH20003470, SMINT20000180, SYNOV20013740, TESTI10000230, TESTI10001680, TESTI20007840, TESTI20021490, TESTI20022230, TESTI20023690, TESTI20030050, TESTI20042950, TESTI20068720, TESTI20080200, TRACH20012890, BRACE20006980, BRACE20092740, BRAWH20006970, FCBBF10007600, FEBRA20062700, IMR3220016000, KIDNE20073280, MAMGL10000350, NT2NE20035690, NT2RI20056470, NT2RI20058110, NT2RI20084810, NT2RI20085260, NT2RP70015910, NT2RP70036290, NT2RP70036320, NT2RP70074220, NT2RP70075370, NTONG10000330, NTONG10000520, NTONG10001230, NTONG10001300, NTONG10001820, NTONG10002140, NTONG10002460, NTONG10002570, NTONG10002640, NTONG20002650, NTONG20003340, NTONG20003630, NTONG20004920, NTONG20005830, NTONG20008000, NTONG20008780, NTONG20009660, NTONG20009850, NTONG20011370, NTONG20012220, NTONG20014280, NTONG20015500, NTONG20016120, OCBBF20011240, OCBBF20015860, PROST10002200, SKMUS20016340, SKNMC20000970, STOMA20004820, SYNOV10001280, SYNOV20011440, THYMU10000830, TRACH20000790, TRACH20009260
  • These genes are involved in cancers.
  • Further, there is a method to search for genes involved in development and differentiation: the expression frequency analysis in which the expression levels of genes are compared between developing or differentiating tissues and/or cells and adult tissues and/or cells. The genes involved in tissue development and/or differentiation are genes participating in tissue construction and expression of function, and thus are useful genes, which are available for regenerative medicine aiming at convenient regeneration of injured tissues.
  • Search was carried out for the genes whose expression frequencies were different between developing and/or differentiating tissues and/or cells, and adult tissues and/or cells, by using the information of gene expression frequency based on the database of the nucleotide sequences of 770,546 clones shown above.
  • The result of comparative analysis of cDNA libraries derived from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE, BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA) showed that the genes whose expression levels were different between the two were the following clones (Tables 16 to 36).
  • BRACE20028960, BRACE20074010, BRACE20077080, BRACE20077980, BRACE20083800, BRACE20088570, BRAWH10000010, BRAWH10000020, BRAWH10000070, BRAWH10000370, BRAWH10000940, BRAWH10001300, BRAWH10001640, BRAWH10001680, BRAWH10001740, BRAWH10001800, BRAWH20000340, BRAWH20000340, BRAWH20000480, BRAWH20000930, BRAWH20001770, BRAWH20002480, BRAWH20003230, BRAWH20004430, BRAWH20004760, BRAWH20005030, BRAWH20005540, BRAWH20006330, BRAWH20006510, BRAWH20006970, BRAWH20008660, BRAWH20008920, BRAWH20009010, BRAWH20009440, BRAWH20009840, BRAWH20011030, BRAWH20011290, BRAWH20011660, BRAWH20012030, BRAWH20014180, BRAWH20014380, BRAWH20014610, BRAWH20015030, BRAWH20036890, BRAWH20038320, BRAWH20047310, BRAWH20059980, BRAWH20060440, BRAWH20064930, BRAWH20066220, BRAWH20069600, BRAWH20069890, BRAWH20074060, BRAWH20076050, BRAWH20089560, BRAWH20092270, BRAWH20092610, BRAWH20093600, BRAWH20094850, IMR3220013170, KIDNE20000850, KIDNE20004220, KIDNE20031850, KIDNE20050420, MAMGL10000350, NT2NE20001740, NT2RI20042840, NT2RI20086560, NT2RP70002590, NT2RP70065270, NT2RP70074220, NTONG10001820, PEBLM20001470, PLACE60032040, SKMUS10000140, SMINT20005450, TESTI20004350, TESTI20008830, TRACH20007800, TRACH20016070, UMVEN20001330, 3NB6910001730, 3NB6920002810, ADRGL20000740, BNGH410001370, BNGH410001980, BRACE10000200, BRACE10000730, BRACE10000930, BRACE20000770, BRACE20001000, BRACE20001410, BRACE20002800, BRACE20003320, BRACE20005050, BRACE20005250, BRACE20005450, BRACE20005650, BRACE20005650, BRACE20005770, BRACE20006980, BRACE20007180, BRACE20008850, BRACE20009880, BRACE20010650, BRACE20010700, BRACE20011170, BRACE20011430, BRACE20011430, BRACE20011880, BRACE20013400, BRACE20013520, BRACE20013740, BRACE20013750, BRACE20014230, BRACE20014530, BRACE20014550, BRACE20014770, BRACE20014920, BRACE20015080, BRACE20015430, BRACE20016730, BRACE20016920, BRACE20017370, BRACE20018550, BRACE20018590, BRACE20018650, BRACE20018980, BRACE20021510, BRACE20021760, BRACE20022020, BRACE20022270, BRACE20024090, BRACE20024090, BRACE20024310, BRACE20024680, BRACE20024950, BRACE20025900, BRACE20026350, BRACE20026850, BRACE20027360, BRACE20027520, BRACE20027550, BRACE20027720, BRACE20027920, BRACE20027960, BRACE20028120, BRACE20028600, BRACE20030780, BRACE20032850, BRACE20033190, BRACE20033980, BRACE20034310, BRACE20035160, BRACE20035940, BRACE20071380, BRACE20071530, BRACE20071970, BRACE20072010, BRACE20072320, BRACE20072810, BRACE20074470, BRACE20075020, BRACE20075270, BRACE20075380, BRACE20075630, BRACE20076210, BRACE20076460, BRACE20076630, BRACE20076850, BRACE20077610, BRACE20077640, BRACE20077670, BRACE20077840, BRACE20078680, BRACE20079020, BRACE20079530, BRACE20080970, BRACE20081140, BRACE20083850, BRACE20084430, BRACE20084880, BRACE20086530, BRACE20086550, BRACE20087080, BRACE20087540, BRACE20089600, BRACE20089990, BRACE20090140, BRACE20091880, BRACE20092120, BRACE20092750, BRACE20093070, BRACE20093110, BRACE20094370, CTONG20008270, CTONG20013200, CTONG20020730, CTONG20064490, HHDPC20000950, HHDPC20001150, HHDPC20004560, HSYRA10001780, HSYRA20008280, HSYRA20011530, IMR3210002660, IMR3220003020, IMR3220009350, KIDNE20003300, KIDNE20004970, KIDNE20005170, KIDNE20059370, KIDNE20068800, KIDNE20073280, LIVER20000370, MESAN20002670, NT2NE20005170, NT2NE20011560, NT2NE20013640, NT2NE20016970, NT2RI20006710, NT2RI20009740, NT2RI20022430, NT2RI20025300, NT2RI20028020, NT2RI20029260, NT2RI20030110, NT2RI20030510, NT2RI20040590, NT2RI20046060, NT2RI20049840, NT2RI20049850, NT2RI20056470, NT2RI20060720, NT2RI20062100, NT2RI20067350, NT2RI20068250, NT2RI20070840, NT2RI20070960, NT2RI20071480, NT2RI20072540, NT2RI20074980, NT2RI20085260, NT2RI20088120, NT2RI20090660, NT2RI20090830, NT2RP70013060, NT2RP70013350, NT2RP70023760, NT2RP70024500, NT2RP70030910, NT2RP70036320, NT2RP70036470, NT2RP70042330, NT2RP70054930, NT2RP70064900, NT2RP70071140, NT2RP70075370, NT2RP70076100, NT2RP70079750, NT2RP70081370, NT2RP70090120, NT2RP70091490, NT2RP70093730, NTONG20014280, NTONG20015500, PEBLM10000340, PLACE60014430, PLACE60020840, PLACE60024190, PLACE60026920, PLACE60030380, PLACE60038500, PLACE60043970, PROST10002720, PROST20000530, PROST20021620, PROST20032320, PROST20033380, PROST20062600, SALGL10000050, SALGL10001570, SKMUS10000220, SKMUS20001170, SKMUS20002710, SKMUS20009540, SKMUS20011290, SKMUS20015010, SKMUS20015430, SKMUS20016340, SKNMC20002240, SKNMC20015030, SKNSH20001510, SMINT10001000, SMINT20002390, SPLEN20001970, STOMA20001210, STOMA20002570, SYNOV20002910, SYNOV20011440, TESTI10000510, TESTI10000700, TESTI10001680, TESTI20005200, TESTI20015110, TESTI20018290, TESTI20018690, TESTI20018980, TESTI20024670, TESTI20032800, TESTI20033250, TESTI20036250, TESTI20136910, THYMU10000830, THYMU10003290, THYMU10003590, UTERU10000960, UTERU20005690, ADRGL10000650, BGGI120010970, BRACE20004210, BRACE20020500, BRACE20020910, BRACE20024780, BRACE20028610, BRACE20031100, BRACE20035270, BRACE20035390, BRACE20071740, BRACE20077270, BRAWH20001090, CTONG20024530, CTONG20028200, CTONG20055530, FCBBF10005980, FCBBF10006180, FCBBF10006870, FCBBF10006910, FCBBF10007320, FCBBF10007600, FCBBF20000940, FCBBF20001050, FCBBF20001950, FCBBF20002320, FCBBF20002760, FCBBF20005760, FCBBF20005910, FCBBF20006770, FCBBF20007330, FCBBF20008080, FCBBF20008150, FCBBF20009400, FCBBF20009510, FCBBF20012110, FCBBF20012990, FCBBF20014800, FCBBF20016720, FCBBF20017180, FCBBF20017200, FCBBF40002820, HCASM10001150, HHDPC20001490, HLUNG10000640, HLUNG20003140, HLUNG20005010, HSYRA20001350, HSYRA20014760, HSYRA20016310, IMR3220007420, IMR3220009730, IMR3220009840, IMR3220012180, IMR3220013320, KIDNE20002660, KIDNE20056760, KIDNE20073520, LIVER20004160, MESAN20000920, NT2NE20015300, NT2NE20035690, NT2RI20010910, NT2RI20016210, NT2RI20016570, NT2RI20033040, NT2RI20033440, NT2RI20058110, NT2RI20065060, NT2RI20087490, NT2RP60000720, NT2RP70002710, NT2RP70012310, NT2RP70036800, NT2RP70055020, NT2RP70055130, NT2RP70061880, NT2RP70084410, PLACE60037450, PLACE60049310, PROST10005260, PROST20018230, PROST20051430, SKMUS20000740, SKMUS20011470, SKNMC20003560, SKNSH20001630, SPLEN10000490, STOMA20002890, SYNOV20013740, TESTI20011410, TESTI20033760, TESTI20074640, TRACH10000300, TRACH20013950, 3NB6920003300, 3NB6920009120, ADRGL10000180, BRACE10001150, BRACE10001590, BRACE10001690, BRACE20077680, BRACE20092740, BRACE20093610, BRACE20095170, BRAWH20011410, BRAWH20036930, BRAWH20064500, BRAWH20087060, CTONG20019110, FEBRA20000350, FEBRA20000530, FEBRA20001050, FEBRA20001290, FEBRA20003110, FEBRA20003300, FEBRA20003780, FEBRA20003910, FEBRA20003970, FEBRA20003990, FEBRA20004040, FEBRA20004150, FEBRA20004540, FEBRA20004910, FEBRA20006560, FEBRA20006800, FEBRA20006900, FEBRA20007330, FEBRA20007400, FEBRA20007710, FEBRA20007720, FEBRA20007870, FEBRA20008090, FEBRA20008560, FEBRA20008800, FEBRA20008810, FEBRA20009590, FEBRA20009720, FEBRA20010930, FEBRA20011330, FEBRA20011460, FEBRA20012270, FEBRA20012940, FEBRA20013510, FEBRA20014870, FEBRA20015900, FEBRA20015910, FEBRA20017060, FEBRA20017900, FEBRA20019890, FEBRA20020860, FEBRA20024290, FEBRA20024420, FEBRA20027270, FEBRA20027830, FEBRA20028820, FEBRA20028970, FEBRA20029080, FEBRA20030540, FEBRA20031550, FEBRA20033080, FEBRA20034290, FEBRA20037070, FEBRA20041100, FEBRA20041910, FEBRA20042240, FEBRA20042370, FEBRA20042930, FEBRA20043290, FEBRA20044430, FEBRA20044900, FEBRA20045920, FEBRA20048180, FEBRA20050140, FEBRA20050790, FEBRA20052160, FEBRA20053770, FEBRA20053800, FEBRA20054270, FEBRA20057260, FEBRA20057520, FEBRA20059980, FEBRA20060920, FEBRA20061500, FEBRA20062700, FEBRA20063150, FEBRA20063540, FEBRA20064760, FEBRA20066670, FEBRA20067360, FEBRA20067930, FEBRA20068730, FEBRA20069420, FEBRA20070170, FEBRA20072000, FEBRA20072800, FEBRA20074140, FEBRA20075510, FEBRA20075660, HSYRA20006400, HSYRA20015800, IMR3220002230, KIDNE20005740, KIDNE20053360, NT2NE20002140, NT2NE20003270, NT2NE20003840, NT2NE20007870, NT2NE20047160, NT2NE20053710, NT2RI20025410, NT2RI20051500, NT2RI20055640, NT2RI20058510, NT2RI20061830, NT2RI20064120, NT2RI20071330, NT2RI20075890, NT2RI20077230, NT2RI20094060, NT2RP70002380, NT2RP70009060, NT2RP70015910, NT2RP70094810, NT2RP70094980, PLACE60012810, PLACE60040050, SKMUS20008630, SKNMC20003050, SKNSH20003470, TESTI20003560, TESTI20012690, TESTI20030710, TESTI20082400, TRACH20009260, 3NB6910001160, 3NB6920015280, BRACE10000700, BRACE20019440, BRAWH20052250, KIDNE20045340, NT2NE20002590, NT2NE20014030, NT2RI20020220, NT2RI20026540, NT2RI20060710, NT2RI20083960, NT2RI20084810, NT2RP70011660, NT2RP70021510, NT2RP70024490, NT2RP70026190, NT2RP70039600, NT2RP70049250, NT2RP70071770, NT2RP70093940, NTONG10002640, NTONG20002650, OCBBF10000420, OCBBF10000670, OCBBF10000860, OCBBF10000910, OCBBF10001040, OCBBF10001180, OCBBF10001190, OCBBF10001220, OCBBF20002770, OCBBF20002870, OCBBF20007190, OCBBF20008240, OCBBF20009980, OCBBF20010750, OCBBF20011010, OCBBF20011400, OCBBF20011760, OCBBF20014080, OCBBF20014940, OCBBF20015270, OCBBF20015280, OCBBF20015860, OCBBF20017060, PLACE60043960, SMINT20002770, TESTI20001790, TESTI20007840, TESTI20009700, TESTI20027070, TESTI20053960, TRACH20000790, 3NB6920010220, BRACE10001870, BRAWH20014840, BRAWH20040950, FEBRA20011970, KIDNE20062480, NT2RI20029580, NT2RI20035560, NT2RI20043980, NT2RP70000760, NT2RP70042040, NT2RP70069860, NT2RP70088550, OCBBF20001260, TESTI10000230, 3NB6920017190, ADRGL10000020, BRACE10001660, BRAWH10001620, CTONG20028030, KIDNE20004030, KIDNE20060300, NB9N420000420, NT2NE20000560, NT2NE20004700, NT2NE20007630, NT2RI20004120, NT2RI20013420, NT2RI20033380, NT2RI20036950, NT2RI20053350, NT2RI20053680, NT2RI20078840, NT2RI20083360, NT2RI20090650, NT2RP60001090, NT2RP70004770, NT2RP70023790, NT2RP70055200, NT2RP70085570, NTONG10000980, NTONG20016120, OCBBF20011240, OCBBF20012100, OCBBF20013070, OCBBF20014020, PEBLM20003950, PLACE50001130, PLACE60021510, PUAEN10000570, SKNMC20000970, TESTI20040310, TRACH20004610, 3NB6920005450, BRACE10000420, BRACE20076410, BRACE20078820, BRAWH20006860, BRAWH20089030, FCBBF10006750, FCBBF10006860, FCBBF20015380, FCBBF50002610, FEBRA20004520, FEBRA20005360, FEBRA20009010, FEBRA20014920, FEBRA20015840, FEBRA20021910, FEBRA20021940, FEBRA20043250, FEBRA20057780, FEBRA20057880, FEBRA20066270, FEBRA20074580, HHDPC20000550, HSYRA20015740, HSYRA20016210, IMR3210002420, IMR3220016000, KIDNE20060140, MAMGL10000320, NT2NE20008090, NT2NE20014350, NT2RI20000640, NT2RI20002940, NT2RI20015400, NT2RI20033830, NT2RI20037510, NT2RI20057230, NT2RI20087910, NT2RI20089420, NT2RP70043730, NT2RP70047900, PLACE60043120, PROST20033020, SYNOV10001280, TESTI20021490, THYMU20002360, TRACH20012890, 3NB6910001290, BNGH420004740, BRACE20034490, BRAWH20005220, FEBRA20003770, FEBRA20007570, FEBRA20008740, FEBRA20012450, FEBRA20012450, FEBRA20017150, FEBRA20025250, FEBRA20044120, FEBRA20076220, HSYRA20002480, IMR3220014350, MESAN20001490, NHNPC20002060, NT2NE10000180, NT2NE20003920, NT2RI20006690, NT2RI20013850, NT2RI20014500, NT2RI20025540, NT2RI20033010, NT2RI20075720, NT2RP60000350, NT2RP60001230, NT2RP70028750, NT2RP70029060, NT2RP70032030, NTONG20003340, OCBBF20000130, OCBBF20002310, OCBBF20009040, SKNMC20000650, SMINT20003960, TESTI20026320, TESTI20080200
  • The result of comparative analysis of cDNA libraries derived from fetal heart (FEHRT) and adult heart (HEART) showed that the genes whose expression levels were different between the two were the following clones (Table 37).
  • KIDNE20062480, NT2RI20033040, NT2RP60000350, BGGI120010970, BRACE10000420, BRACE10001150, BRACE20003320, BRACE20077980, BRAWH10000370, BRAWH20000340, BRAWH20011660, BRAWH20014840, FEBRA20008740, FEBRA20072800, HEART20000350, HEART20000990, HEART20003090, HEART20004110, HEART20004480, HEART20004920, HEART20005060, HEART20005200, HEART20005680, HHDPC20001150, HLUNG20005010, HSYRA20014200, IMR3220013170, KIDNE20004970, NT2RI20000640, NT2RI20006710, NT2RI20015400, NT2RI20026540, NT2RI20037510, NT2RI20057230, NT2RI20064120, NT2RI20071330, NT2RI20071480, NT2RI20077540, NT2RI20084810, NT2RI20087910, NT2RP70000760, NT2RP70024500, NT2RP70029060, NTONG10001820, PLACE60012810, PLACE60043120, PROST20000530, SKMUS10000640, SKMUS20004580, SKMUS20015010, SMINT20002770, TESTI20033250, TESTI20074640, UMVEN20001330
  • The result of comparative analysis of cDNA libraries derived from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the genes whose expression levels were different between the two were the following clones (Table 38).
  • 3NB6920003300, 3NB6920009120, BGGI120010970, BRACE20004210, BRACE20005250, BRACE20011170, BRACE20020910, BRACE20026850, BRACE20080970, BRAWH20000340, BRAWH20006970, BRAWH20011660, FCBBF20001950, FEBRA20021940, FEBRA20043250, HLUNG10000640, IMR3220007420, IMR3220014350, KIDNE10000280, KIDNE10000500, KIDNE10001040, KIDNE10001430, KIDNE10001450, KIDNE10001520, KIDNE20000410, KIDNE20000510, KIDNE20000700, KIDNE20000850, KIDNE20001670, KIDNE20001920, KIDNE20002440, KIDNE20002450, KIDNE20002660, KIDNE20003150, KIDNE20003300, KIDNE20003490, KIDNE20003750, KIDNE20004030, KIDNE20004220, KIDNE20004970, KIDNE20005130, KIDNE20005170, KIDNE20005190, KIDNE20005740, KIDNE20031850, KIDNE20033050, KIDNE20033350, KIDNE20033570, KIDNE20033730, KIDNE20033770, KIDNE20037520, KIDNE20039410, KIDNE20039940, KIDNE20040340, KIDNE20040540, KIDNE20040840, KIDNE20042620, KIDNE20042940, KIDNE20042950, KIDNE20043440, KIDNE20045200, KIDNE20045340, KIDNE20045790, KIDNE20046810, KIDNE20048280, KIDNE20048640, KIDNE20048790, KIDNE20049810, KIDNE20050420, KIDNE20052960, KIDNE20053360, KIDNE20054000, KIDNE20054770, KIDNE20056290, KIDNE20056760, KIDNE20059080, KIDNE20059370, KIDNE20060140, KIDNE20060300, KIDNE20060530, KIDNE20060620, KIDNE20061490, KIDNE20062480, KIDNE20062990, KIDNE20063530, KIDNE20063760, KIDNE20066520, KIDNE20067600, KIDNE20067750, KIDNE20068800, KIDNE20070050, KIDNE20070770, KIDNE20071860, KIDNE20073280, KIDNE20073520, KIDNE20073560, KIDNE20074220, KIDNE20075690, KIDNE20078100, KIDNE20078110, LIVER10000790, MAMGL10000320, NB9N410000470, NT2NE20053710, NT2RI20006710, NT2RI20013420, NT2RI20016570, NT2RI20018460, NT2RI20025540, NT2RI20040590, NT2RI20065530, NT2RI20087490, NT2RI20087910, NT2RP60000350, NT2RP60001230, NT2RP70043730, NT2RP70069860, NT2RP70074220, OCBBF20014940, PLACE60014430, PLACE60020840, PLACE60043120, PROST10003430, SKNMC20000970, SKNSH20001510, SMINT10000160, SMINT20003960, SPLEN20000470, SPLEN20001340, SPLEN20003570, STOMA10000470, SYNOV10001280, TESTI10000700, TESTI20027070, TESTI20040310, TRACH10000300, TRACH20000790, TRACH20002500, TRACH20007800, KIDNE10000080, KIDNE20044110, NT2RI20033040, NT2RI20037510, NT2RP70065270, TRACH20012890
  • The result of comparative analysis of cDNA libraries derived from fetal lung (FELNG) and adult lung (HLUNG) showed that the genes whose expression levels were different between the two were the following clones (Table 39).
  • BNGH410001980, BRACE10000420, BRACE10001150, BRACE20014770, BRACE20018550, BRAWH20006970, BRAWH20014610, FEBRA20008810, FEBRA20015840, FEBRA20044120, HHDPC20001490, HLUNG10000240, HLUNG10000300, HLUNG10000370, HLUNG10000640, HLUNG10000760, HLUNG10000990, HLUNG10001050, HLUNG10001100, HLUNG20000680, HLUNG20001160, HLUNG20001250, HLUNG20001420, HLUNG20001760, HLUNG20002550, HLUNG20003140, HLUNG20004120, HLUNG20004800, HLUNG20005010, HSYRA20014200, KIDNE20002660, KIDNE20033050, NT2NE20014350, NT2RI20016570, NT2RI20026540, NT2RI20051500, NT2RI20064120, NT2RI20083960, NT2RI20085260, NT2RI20087490, NT2RP70009060, NT2RP70011660, NT2RP70029060, NT2RP70055020, NT2RP70074220, NT2RP70076100, NTONG10002460, NTONG20008000, PLACE60043120, SKMUS20016340, SKNMC20005930, SMINT20000180, SMINT20002390, SMINT20002770, SMINT20003960, STOMA10000470, STOMA20001880, SYNOV20013740, TESTI20036250, TESTI20080200, TRACH20004610, BRACE20004210, IMR3220007420
  • These genes are involved in regeneration of tissues and/or cells.
    • EXAMPLE 8 Expression Frequency Analysis by PCR
  • Specific PCR primers were prepared based on the full-length nucleotide sequences, and the expression frequency was analyzed by the ATAC-PCR method (Adaptor-tagged competitive PCR method: Nucleic Acids Research 1997, 25(22): 4694-4696; “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Inflammation-related genes can be identified by revealing the genes whose expression levels are altered depending on the presence of an inflammation-inducing factor. Then, by using THP-1 cell line, which is a cell line of monocyte line, and TNF-α and LPS, both of which are inflammation-inducing factors, suitable for this system, the genes whose expression levels are altered depending on the presence of the factors were searched for by the system.
  • THP-1 cell line (purchased from DAINIPPON PHARMACEUTICAL) was cultured to be confluent in RPMI1640 medium (sigma) containing 5% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 10 ng/ml TNF-α (human recombinant TNF-α; Pharmacia Biotech) or 1 μg/mL LPS (Lipopolysaccharides; sigma), and the culture was continued at 37° C. under 5% CO2. After three hours, the cells were harvested, and total RNA was extracted from them by using ISOGEN reagent (Nippon Gene). The extraction was carried out according to the method in the document attached to ISOGEN reagent. In addition, total RNA was also extracted from the cells cultured without stimulation of TNF-α or LPS.
  • The genes involved in the onset of gastritis and gastroduodenal ulcer induced by the infection of Helicobacter pylori to the epithelia of stomach can be identified by revealing the genes whose expression levels are altered depending on co-culturing the cells with Helicobacter pylori. Then, by using co-culture of a gastric cancer cell line with Helicobacter pylori, suitable for this system, the genes whose expression levels are altered depending on the presence of Helicobacter pylori, were searched for by the system.
  • A gastric cancer cell line MKN45 (provided by the Cell Bank, RIKEN GENE BANK, The Institute of Physical and Chemical Research) was cultured to be confluent in RPMI1640 medium (sigma) containing 10% fetal calf serum (GIBCO BRL). Then, the medium was changed with the medium containing 100-fold excess (in terms of the number of cells or the number of colonies) of Helicobacter pylori (TN2 strain: provided by Prof. Omata, Faculty of Medicine, The University of Tokyo), as compared with the number of the cancer cells. The culture was continued at 37° C. under 5% CO2. After three hours, the cells were harvested, and total RNA was extracted from them by using ISOGEN reagent (Nippon Gene). The extraction was carried out according to the method in the document attached to ISOGEN reagent. In addition, total RNA was also extracted from the cells cultured without Helicobacter pylori.
  • The analysis by the ATAC-PCR method was carried out basically according to “DNA Micro-array and Advanced PCR Techniques”, Cell Technology, supplement (Genome Science Series 1, Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Adapter ligation to the internal standard sample (sample to make the calibration curve for the clone of interest) and test sample was carried out in the two separate reaction systems indicated below. The combination of 6 types of adapters (AD-1, AD-2, AD-3, AD-4, AD-5 and AD-6: see the sequences indicated below) and the samples are as follows.
  • Reaction System A
  • AD1; internal standard, 10-fold
  • AD2; THP-1 cells, unstimulated
  • AD3; internal standard, 3-fold
  • AD4; THP-1 cells, TNF-α stimulation
  • AD5; THP-1 cells, LPS stimulation
  • AD6; internal standard, 1-fold
  • Reaction System B
  • AD1; internal standard, 1-fold
  • AD2; MKN45 cells, unstimulated
  • AD3; internal standard, 3-fold
  • AD4; MKN45 cells, co-cultured with Helicobacter pylori
  • AD5; internal standard, 10-fold
  • Adapter Sequences:
    AD1;
    SEQ ID NO:
    3283//5′-GTACATATTGTCGTTAGAACGCG-3′
    SEQ ID NO:
    3284//3′-CATGTATAACAGCAATCTTGCGCCTAG-5′
    AD2;
    SEQ ID NO:
    3285//5′-GTACATATTGTGGTTAGAACGCGACT-3′
    SEQ ID NO:
    3286//3′-CATGTATAACAGCAATCTTGCGCTGACTAG-5′
    AD3;
    SEQ ID NO:
    3287//5′-GTACATATTGTCGTTAGAACGCGCATACT-3′
    SEQ ID NO:
    3288//3′-CATGTATAACAGCAATCTTGCGCGTATGACTAG-5′
    AD4;
    SEQ ID NO:
    3289//5′-GTACATATTGTCGTTAGAACGCGATCCATACT-3′
    SEQ ID NO:
    3290//3′-CATGTATAACAGCAATCTTGCGCTAGGTATGACTAG-5′
    AD5;
    SEQ ID NO:
    3291//5′-GTACATATTGTCGTTAGAACGCGTCAATCCATAcT-3′
    SEQ ID NO:
    3292//3′-CATGTATAACAGCAATCTTGCGCAGTTAGGTATGAcTA
    G-5′
    AD6;
    SEQ ID NO:
    3293//5′-GTACATATTGTCGTTAGAACGCGTACTCAATCCATACT-3′
    SEQ ID NO:
    3294//3′-CATGTATAACAGCAATCTTGCGCATGAGTTAGGTATGACTA
    G-5′
  • The internal standard sample used for this assay was a mixture of total RNAs of THP-1 Control, MKN45 Control, NT2 (Stratagene; catalog No. 204101). RNA preparation from the culture cells was carried out according to the standard method.
  • The sequences of primers specific to the genes and the names of clones of interest in the analysis are as follows. The gene specific primers were designed to produce the PCR products of 70 to 200 bp, which are derived from the adapter-containing cDNA. The sequence of adapter-specific primer (labeled with fluorescence (FAM)) used in the competitive PCR was GTACATATTGTCGTTAGAACGC (22 nucleotides; SEQ ID NO: 3295). PCR was basically carried out with a cycling profile of preheating at 94° C. for 3 minutes, and 30 cycles of denaturation at 94° C. for 30 seconds/annealing at 50° C. for 60 seconds/extension at 72° C. for 90 seconds; in some cases, merely the annealing temperature was changed.
  • The Nucleotide Sequences of Clone Specific Primers Used in the Experiments
  • Clone name, primer sequence and SEQ ID NO are indicated below in this order. Each is demarcated by a double slash mark (//).
    SEQ ID NO: 3296
    3NB6920000290//CTCCTCCAGCAGAACTTG//
    SEQ ID NO: 3297
    ADRGL10000180//TTTAGAGCTGATTCCCCATT//
    SEQ ID NO: 3298
    BNGH410001370//TAAAAGcAGGAAATTGTAAA//
    SEQ ID NO: 3299
    BRACE10001590//ATATGGACAAAGGACCAATT//
    SEQ ID NO: 3300
    BRACE10001690//AGGACTAGATTCACTGCTTA//
    SEQ ID NO: 3301
    BRACE20010650//CAACTCTCAACACCACAATC//
    SEQ ID NO: 3302
    BRACE20013400//CTACTCAAGGACAGCCACAC//
    SEQ ID NO: 3303
    BRACE20030780//AGATAGAGGCTTGCTGGTGT//
    SEQ ID NO: 3304
    BRACE20034490//CCTTATGTCAAACTGCGATT//
    SEQ ID NO: 3305
    BRACE20077640//TTTGCCTTATTCATTGGTTG//
    SEQ ID NO: 3306
    BRACE20079530//GTAATATCACCCCACAGAGG//
    SEQ ID NO: 3307
    BRACE20083850//TATCATCTTTTGGGGCTTTG//
    SEQ ID NO: 3308
    BRACE20091880//AATAAGCCAGTTGCATCCTC//
    SEQ ID NO: 3309
    BRAWH10001620//TCTCTGATCTCCAACATGC//
    SEQ ID NO: 3310
    BRAWH20004430//TGAATTGAAGAGACACACT//
    SEQ ID NO: 3311
    FCBBF10006180//CTTAATCCAGTTCATCAGCT//
    SEQ ID NO: 3312
    FEBRA20003780//TTTTGAGACAGAGTTTCGCT//
    SEQ ID NO: 3313
    FEBRA20006800//ATGTTTTACGATTGCCTTTG//
    SEQ ID NO: 3314
    FEBRA20008810//GAAGCATCTTTGGTGTACTA//
    SEQ ID NO: 3315
    FEBRA20012940//TGTCCGTGGAGTATATA//
    SEQ ID NO: 3316
    FEBRA20015840//AACACAGTAGCCAGACCAG//
    SEQ ID NO: 3317
    HCASM10000610//AAGAGCCTACTACACGCCAG//
    SEQ ID NO: 3318
    HEART20000350//TTTAAGAGCACACAGAGTC//
    SEQ ID NO: 3319
    HEART20004480//ATTACTGGTGTGGAGTGGGT//
    SEQ ID NO: 3320
    HEART20005060//ACTCTGCCTTCACTTTCCTT//
    SEQ ID NO: 3321
    HHDPC20000950//GATAAAGGATACAGCCApA//
    SEQ ID NO: 3322
    HLUNG10000370//ATCATGGTCGTTACAGAATT//
    SEQ ID NO: 3323
    HLUNG20001160//ACTGCCTTCATCTCAGGTT//
    SEQ ID NO: 3324
    HLUNG20001760//ATCACTGCCAATTTCACA//
    SEQ ID NO: 3325
    HSYRA20003470//CCACCGAGTTCTGTTG//
    SEQ ID NO: 3326
    HSYRA20013320//GTCATGGCCACAGTTGTATC//
    SEQ ID NO: 3327
    IMR3210001580//GATAAAGGATACAGCCApA//
    SEQ ID NO: 3328
    IMR3210002660//CCCAAAATGTGTATTATTCA//
    SEQ ID NO: 3329
    IMR3220008380//TTCGGCAATAATCTTCTCTT//
    SEQ ID NO: 3330
    IMR3220008590//CCACCAACACTTAGACATCA//
    SEQ ID NO: 3331
    KIDNE10001520//GAATTATAGGTGCACACAC//
    SEQ ID NO: 3332
    KIDNE20000850//TCTTCTAGTGGAAGAGGTTTA//
    SEQ ID NO: 3333
    KIDNE20003490//TATCTGAAAATGTGTTTGGT//
    SEQ ID NO: 3334
    KIDNE20005170//ACTCCTGGCTTTCTATTTCC//
    SEQ ID NO: 3335
    KIDNE20033730//GACAGTCTCGCTGTATCTCC//
    SEQ ID NO: 3336
    KIDNE20040540//ACATCCAGTACACCTTCTCC//
    SEQ ID NO: 3337
    KIDNE20050420//GTCGAAAGTGTTGCTCCTAG//
    SEQ ID NO: 3338
    KIDNE20061490//TCATAGCTGAGGGGTTAGT//
    SEQ ID NO: 3339
    KIDNE20062990//ATAGCTCTTGTTTCAGTGTG//
    SEQ ID NO: 3340
    LIVER20000330//AAGCATGTGGGAGTTATTTA//
    SEQ ID NO: 3341
    NT2NE10001630//CTTGAGAGTCCAGGTTTCCT//
    SEQ ID NO: 3342
    NT2NE10001850//CCCATAAAGAATAGAGCTC//
    SEQ ID NO: 3343
    NT2NE20003920//CTCATGGGGCTAGTCTATT//
    SEQ ID NO: 3344
    NT2NE20005500//TCAAAGTCCAGGATAGCATT//
    SEQ ID NO: 3345
    NT2R120009740//ACTGATTTGGTTCTGCGATT//
    SEQ ID NO: 3346
    NT2R120014500//GTTACTTCGAGTTCTAGCAC//
    SEQ ID NO: 3347
    NT2R120016570//TGCTGCTCATGTTWCTTG//
    SEQ ID NO: 3348
    NT2R120018660//AAACATCATCTCTTCCTTGG//
    SEQ ID NO: 3349
    NT2RI2002152Q//GCTGAGAGACATAGTC//
    SEQ ID NO: 3350
    NT2R120050870//GACAGAGTAGTGGGGCATCT//
    SEQ ID NO: 3351
    NT2RI20053350//TTCAGCAGGTAGACACATC//
    SEQ ID NO: 3352
    NT2R120070480//CCTCTCTTTCAGTTGAGCAT//
    SEQ ID NO: 3353
    NT2R120073030//GGGCTTGTTTTAGGC//
    SEQ ID NO: 3354
    NT2RI20078270//CCTAGGCAGTAGATGA//
    SEQ ID NO: 3355
    NT2R120078790//GCAGACAGGTACAGCTGAGT//
    SEQ ID NO: 3356
    NT2R120083360//TTATTTTAGTTACCTTGGCA//
    SEQ ID NO: 3357
    NT2RP60000080//ACTGTAAATCTCCTTGCCTT//
    SEQ ID NO: 3358
    NT2RP60000390//GAGTTTGGGGACAGTCAGT//
    SEQ ID NO: 3359
    NT2RP60000590//AAATGCAAAATTGCTGAGAT//
    SEQ ID NO: 3360
    NTONG10000980//TTCAGCAGGTAGACAACATC//
    SEQ ID NO: 3361
    NTONG10002570//GTCGCTGAAATTTGCTTCTT//
    SEQ ID NO: 3362
    PLACE60020160//CCATATCCACTTTCATCATC//
    SEQ ID NO: 3363
    PLACE60026990//CAAGAAACTGACAATCACGG//
    SEQ ID NO: 3364
    PLACE60047380//AAGGAGTTGACATTTTGCTG//
    SEQ ID NO: 3365
    PUAEN10003220//TTTTCAGAGGGCTTTGTGTT//
    SEQ ID NO: 3366
    SKNMC10000290//ATAACTGAACCCATGGAAAG//
    SEQ ID NO: 3367
    SKNMC10001590//ACATCCAGTACACCTTCTCC//
    SEQ ID NO: 3368
    SKNMC20000650//GCACTAGGAGACTGTCAAAA//
    SEQ ID NO: 3369
    STOMA20002570//GGTATCTTGGAGCTCCTCAG//
    SEQ ID NO: 3370
    STOMA20002890//GTCAGCATCTACTCTGGGTC//
    SEQ ID NO: 3371
    SYNOV20001770//AAGAAATAAACACACGAAAA//
    SEQ ID NO: 3372
    TESTI10000230//AAATGCAAAATTGCTGAGAT//
    SEQ ID NO: 3373
    TESTI10000550//CAGAACACTCCTCATACCTC//
    SEQ ID NO: 3374
    TESTI20011340//AAAGTACAGCAGAAGATGGG//
    SEQ ID NO: 3375
    THYMU10005580//AACAGCTTCTTCATCACAGT//
    SEQ ID NO: 3376
    TPACH10000630//ATAGAGGAAGGTGGCAACTG//
    SEQ ID NO: 3377
    TRACH20001960//CTCTTTTCCATCACATTCCC//
    SEQ ID NO: 3378
    UMVEN10001220//CCAAGTTCTCATTCCACATT//
    SEQ ID NO: 3379
    UMVEN2000133Q//AGCTAACAAGGTTTTGACAC//
    SEQ ID NO: 3380
    UTERU20004850//AGACTGGGTCTTGCCATACT//
  • The result of expression frequency analysis is shown in Table 40. The clones not shown in the table contain clones whose expression levels could not be measured because the levels were too low or the sizes of the PCR products were different from the expected. It was confirmed that the expression levels of TNF-α, IL-1, and IL-8 genes used as positive control genes were elevated.
  • The result obtained by the search for the genes whose expression levels were altered depending on the presence of TNF-α or LPS in culturing THP-1 cell, which is a human monocyte cell line, showed that the clones whose expression levels were elevated by twofold or more depending on the TNF-α stimulation (the clones whose expression levels were 0.1 or lower both before and after the stimulation were excluded), were ADRGL10000180, BRACE20030780, BRACE20077640, BRACE20083850, BRAWH20004430, FCBBF10006180, FEBRA20003780, FEBRA20006800, FEBRA20012940, FEBRA20015840, HEART20004480, HLUNG10000370, HLUNG20001160, HSYRA20013320, IMR3220008380, KIDNE10001520, KIDNE20040540, KIDNE20061490, KIDNE20062990, NT2NE10001630, NT2NE20003920, NT2NE20005500, NT2RI20014500, NT2RI20016570, NT2RI20078270, NT2RI20083360, NTONG10002570, PUAEN10003220, SKNMC10000290, STOMA20002570, TESTI20011340, UTERU20004850.
  • Further, the clones whose expression levels were elevated by twofold or more depending on the LPS stimulation (the clones whose expression levels were 0.1 or lower both before and after the stimulation were excluded), were FCBBF10006180, FEBRA20015840, HLUNG10000370, HLUNG20001160, HSYRA20013320, KIDNE20040540, KIDNE20061490, NT2NE10001630, NT2NE20003920, NT2NE20005500, NT2RI20014500, NT2RI20016570, NT2RI20078270, NTONG10002570, PUAEN10003220, STOMA20002570, TESTI20011340. These genes whose expression levels were elevated by LPS stimulation, were all up-regulated by the TNF-α stimulation.
  • On the other hand, with respect to the genes whose expression is suppressed, in particular cases where the expression levels were relatively high in the unstimulated cells (the relative value were 1 or higher), the clones whose expression levels were decreased by twofold or more by the TNF-α stimulation, were BRACE20013400, BRACE20091880, HEART20005060, HLUNG20001760, IMR3220008590, NT2NE10001850, NT2RI20018660, NT2RI20053350, NT2RI20070480, PLACE60047380, STOMA20002890, SYNOV20001770, TRACH20001960. Further, when the levels were normalized by using the ratio of the expression level of β-actin widely used in data normalization for gene expression level, the clones whose expression levels were decreased by tenfold or more depending on the LPS stimulation, were BRACE20013400, BRACE20091880, HEART20005060, HLUNG20001760, NT2RI20070480, UMVEN20001330. Among the genes whose expression levels were decreased by TNF-α stimulation, the genes whose expression levels were also decreased by the LPS stimulation were BRACE20013400, BRACE20091880, HEART20005060, HLUNG20001760, NT2RI20070480.
  • These clones were thus revealed to be involved in the inflammation reaction induced by TNF-α or LPS.
  • The result obtained by the search for the genes whose expression levels were altered depending on co-culturing gastric cancer cell line MKN45 with Helicobacter pylori, showed that the clones whose expression levels were elevated by twofold or more depending on the presence of Helicobacter pylori (the clones whose expression levels were 0.1 or lower both before and after the stimulation were excluded), were BRACE10001590, BRACE20079530, BRAWH10001620, FEBRA20006800, KIDNE20003490, KIDNE20040540, KIDNE20050420, NT2NE10001850, STOMA20002890, SYNOV20001770, TESTI10000550, UTERU20004850. Of the clones, FEBRA20006800, KIDNE20040540 and UTERU20004850 were also up-regulated by TNF-α stimulation in the human monocyte cell line THP-1.
  • On the other hand, with respect to the genes whose expression is suppressed, in particular cases where the expression levels were relatively high in the unstimulated cells in (the relative value were 1 or higher), when the levels were normalized by using the ratio of the expression level of β-actin widely used in data normalization for gene expression level, the clones whose expression levels were decreased by fivefold or more in the presence of Helicobacter pylori, were BRACE20034490, BRACE20077640, BRACE20083850, KIDNE20005170, LIVER20000330, NT2RP60000390, NTONG10000980, UMVEN20001330.
  • These clones are involved in gastritis or gastroduodenal ulcer.
    TABLE 3
    Clone ID CD34C D30ST D60ST D90ST
    KIDNE20062480 0 4.908 0 5.748
    NT2RI20016570 0 7.035 0 8.24
    PLACE60020840 0 8.776 0 20.558
    3NB6920002810 0 0 0 4.74
    BRACE20035270 0 0 0 33.245
    BRAWH20000340 0 0 0 40.521
    FEBRA20062700 0 0 0 35.533
    HSYRA20011030 0 0 0 9.617
    NT2RP70030910 0 0 0 39.804
    OCBBF20011240 0 0 0 44.145
    PLACE60043120 0 0 0 15.442
    SYNOV20011440 0 0 0 15.55
    HCASM10001150 0 0 40.145 0
    IMR3220016000 0 0 13.886 0
    NT2RI20082210 0 0 79.241 0
    D3OST20001840 0 100 0 0
    FEBRA20012940 0 37.059 0 0
    FEBRA20021910 0 63.399 0 0
    IMR3220002230 0 10.991 0 0
    IMR3220012180 0 18.197 0 0
    NT2RI20000640 0 9.996 0 0
    NT2RI20010910 0 46.971 0 0
    NT2RI20058110 0 20.306 0 0
    NT2RP60000350 0 4.385 0 0
    NT2RP70011660 0 8.936 0 0
    PEBLM20003950 0 14.226 0 0
    PLACE60049310 0 68.294 0 0
    PROST20062600 0 66.053 0 0
    TESTI20007840 0 7.864 0 0
    TESTI20040310 0 8.52 0 0
    TESTI20080200 0 4.493 0 0
    THYMU10003590 0 9.698 0 0
    TRACH10000630 0 34.338 0 0
    TRACH20007800 0 18.508 0 0
    CD34C20000510 100 0 0 0
    HSYRA20016210 5.607 0 0 3.6
    KIDNE20004030 66.99 0 0 0
    KIDNE20073280 54.663 0 0 0
    NT2RP70055020 58.521 0 0 0
    PLACE60043960 58.654 16.078 0 0
    SKMUS10000220 57.743 0 0 0
  • TABLE 4
    Clone ID NT2RM NT2RP NT2RI NT2NE
    SKNMC20000970 19 2.312 0.784 1.188
    3NB6920009120 0 2.916 1.978 8.993
    BRAWH20006970 0 4.004 2.717 4.117
    KIDNE20062480 0 1.503 7.137 3.09
    NHNPC20002060 0 1.674 1.136 5.165
    NT2NE20053710 0 7.977 0.773 2.343
    NT2RI20000640 0 1.53 1.038 3.147
    NT2RI20004210 0 29.541 40.087 30.373
    NT2RI20006710 0 2.481 1.683 2.551
    NT2RI20009740 0 13.985 9.489 14.379
    NT2RI20013420 0 4.074 1.382 2.094
    NT2RI20013850 0 6.297 4.273 2.158
    NT2RI20014100 0 53.957 18.305 27.738
    NT2RI20025410 0 17.546 11.905 18.04
    NT2RI20033040 0 3.342 3.401 3.436
    NT2RI20035560 0 28.514 3.869 5.864
    NT2RI20036950 0 4.691 9.549 4.823
    NT2RI20051500 0 3.392 9.205 10.462
    NT2RI20053350 0 2.329 1.581 2.395
    NT2RI20057230 0 2.418 1.641 7.458
    NT2RI20071330 0 13.599 9.227 6.991
    NT2RI20075720 0 4.321 2.932 4.443
    NT2RI20083960 0 8.389 5.692 8.625
    NT2RI20087910 0 5.711 1.938 2.936
    NT2RI20090650 0 2.967 6.039 3.051
    NT2RI20094060 0 26.699 18.115 13.726
    NT2RP60000350 0 5.37 4.554 4.141
    NT2RP70000760 0 4.602 3.122 4.732
    NT2RP70036800 0 6.556 8.897 6.741
    NT2RP70071770 0 18.93 6.422 9.732
    NT2RP70074220 0 4.004 2.717 4.117
    TESTI20007840 0 19.261 3.267 4.951
    TESTI20080200 0 1.375 1.867 1.414
    3NB6920002810 0 1.239 0.841 0
    3NB6920005450 0 7.198 4.884 0
    HSYRA20015740 0 8.09 5.489 0
    HSYRA20016210 0 2.353 1.277 0
    IMR3220016000 0 1.458 0.989 0
    KIDNE20060140 0 14.005 9.502 0
    NT2RI20014490 0 29.632 70.368 0
    NT2RI20015950 0 59.577 40.423 0
    NT2RI20022520 0 59.577 40.423 0
    NT2RI20025170 0 59.577 40.423 0
    NT2RI20025540 0 5.634 3.823 0
    NT2RI20030510 0 15.012 10.186 0
    NT2RI20040590 0 13.827 9.381 0
    NT2RI20046060 0 9.661 13.11 0
    NT2RI20053680 0 3.443 4.672 0
    NT2RI20058510 0 12.325 16.726 0
    NT2RI20066820 0 32.943 67.057 0
    NT2RI20067030 0 59.577 40.423 0
    NT2RI20074980 0 6.002 24.433 0
    NT2RI20075890 0 12.002 8.144 0
    NT2RI20078840 0 22.336 7.578 0
    NT2RI20084810 0 12.646 12.87 0
    NT2RI20089420 0 17.837 18.153 0
    NT2RP70002380 0 44.979 15.259 0
    NT2RP70023790 0 2.283 1.549 0
    NT2RP70029820 0 15.713 10.661 0
    NT2RP70049150 0 59.577 40.423 0
    NT2RP70055020 0 4.911 3.332 0
    NT2RP70065270 0 1.664 1.129 0
    NT2RP70069860 0 10.864 7.371 0
    NT2RP70075370 0 7.229 1.635 0
    NT2RP70079750 0 3.104 2.106 0
    NT2RP70092590 0 17.381 11.793 0
    OCBBF20000130 0 7.346 19.936 0
    PLACE60043970 0 12.827 4.352 0
    TESTI20053960 0 24.609 5.566 0
    BNGH420004740 0 2.789 0 2.867
    HSYRA20002480 0 2.789 0 2.867
    NT2NE10000730 0 24.483 0 75.517
    NT2NE20000560 0 4.458 0 4.584
    NT2NE20003270 0 28.131 0 14.462
    NT2NE20008090 0 34.048 0 17.504
    NT2NE20014030 0 17.216 0 35.403
    NT2RP60000720 0 5.865 0 3.015
    NT2RP60001090 0 3.47 0 3.568
    NT2RP70004770 0 22.083 0 11.353
    NT2RP70010800 0 59.331 0 40.669
    NT2RP70011660 0 5.472 0 2.813
    NT2RP70028750 0 7.823 0 1.609
    NT2RP70029060 0 3.063 0 9.449
    NT2RP70030550 0 49.305 0 50.695
    NT2RP70032030 0 8.843 0 4.546
    NT2RP70036320 0 8.861 0 9.111
    NT2RP70064900 0 32.803 0 33.727
    NT2RP70093220 0 32.957 0 33.885
    NT2RP70093730 0 29.95 0 30.794
    SYNOV20013740 0 11.184 0 11.499
    TESTI20021490 0 20.062 0 6.876
    TRACH20004720 0 5.169 0 2.657
    TRACH20007800 0 11.333 0 11.652
    3NB6920003300 0 0 0.71 1.076
    BRACE10000200 0 0 18.865 28.588
    BRACE20018550 0 0 16.357 12.393
    FEBRA20008740 0 0 2.493 3.778
    FEBRA20074580 0 0 23.056 34.938
    FEBRA20076220 0 0 6.122 2.319
    KIDNE20073520 0 0 4.038 3.06
    MAMGL10000320 0 0 0.39 0.591
    NT2NE20002140 0 0 7.614 11.538
    NT2NE20006360 0 0 18.047 54.696
    NT2NE20007870 0 0 3.883 11.767
    NT2NE20009800 0 0 39.756 60.244
    NT2NE20035690 0 0 14.209 10.766
    NT2RI20002940 0 0 12.546 19.012
    NT2RI20014500 0 0 3.454 5.235
    NT2RI20016210 0 0 21.272 16.117
    NT2RI20029260 0 0 18.069 54.761
    NT2RI20037510 0 0 3.361 5.094
    NT2RI20055640 0 0 19.702 29.855
    NT2RI20064120 0 0 2.899 4.393
    NT2RI20074390 0 0 39.756 60.244
    NT2RI20077230 0 0 14.643 11.094
    NT2RI20090660 0 0 5.676 17.202
    PLACE60040050 0 0 3.883 11.767
    TRACH20012890 0 0 4.391 2.218
    3NB6910001730 0 0 0 2.934
    BRACE10001150 0 0 0 1.941
    BRACE20011170 0 0 0 3.434
    BRACE20020910 0 0 0 19.866
    BRACE20035270 0 0 0 8.935
    BRAWH20005220 0 0 0 12.892
    FEBRA20003970 0 0 0 36.013
    FEBRA20012450 0 0 0 13.643
    HLUNG20003140 0 0 0 13.547
    IMR3220009350 0 0 0 4.198
    IMR3220013170 0 0 0 4.4
    IMR3220013320 0 0 0 2.646
    IMR3220014350 0 0 0 4.254
    NT2NE10000040 0 0 0 49.427
    NT2NE10000140 0 0 0 100
    NT2NE10000180 0 0 0 9.321
    NT2NE10000230 0 0 0 100
    NT2NE10000630 0 0 0 100
    NT2NE10000830 0 0 0 100
    NT2NE10001200 0 0 0 100
    NT2NE10001630 0 0 0 100
    NT2NE10001850 0 0 0 60.858
    NT2NE20000380 0 0 0 64.993
    NT2NE20000640 0 0 0 100
    NT2NE20001740 0 0 0 11.757
    NT2NE20002590 0 0 0 30.217
    NT2NE20002990 0 0 0 100
    NT2NE20003690 0 0 0 100
    NT2NE20003840 0 0 0 3.017
    NT2NE20003920 0 0 0 9.486
    NT2NE20004550 0 0 0 100
    NT2NE20004700 0 0 0 33.507
    NT2NE20005170 0 0 0 61.289
    NT2NE20005360 0 0 0 100
    NT2NE20005500 0 0 0 100
    NT2NE20005860 0 0 0 100
    NT2NE20006580 0 0 0 100
    NT2NE20007060 0 0 0 100
    NT2NE20007630 0 0 0 15.634
    NT2NE20008020 0 0 0 100
    NT2NE20011560 0 0 0 40.371
    NT2NE20012470 0 0 0 100
    NT2NE20013240 0 0 0 100
    NT2NE20013370 0 0 0 100
    NT2NE20013640 0 0 0 49.334
    NT2NE20013720 0 0 0 100
    NT2NE20014280 0 0 0 100
    NT2NE20014350 0 0 0 7.004
    NT2NE20015300 0 0 0 22.636
    NT2NE20016230 0 0 0 100
    NT2NE20016260 0 0 0 100
    NT2NE20016340 0 0 0 100
    NT2NE20016480 0 0 0 100
    NT2NE20016660 0 0 0 100
    NT2NE20016970 0 0 0 61.289
    NT2NE20034080 0 0 0 100
    NT2NE20044900 0 0 0 100
    NT2NE20047160 0 0 0 43
    NT2NE20054410 0 0 0 34.749
    NT2NE20055170 0 0 0 100
    NT2NE20057200 0 0 0 71.845
    OCBBF20009040 0 0 0 38.34
    OCBBF20015860 0 0 0 24.825
    PLACE60020840 0 0 0 8.288
    PROST10005260 0 0 0 11.86
    SKMUS20008630 0 0 0 2.785
    SMINT20003960 0 0 0 1.689
    STOMA20001210 0 0 0 2.199
    SYNOV20011440 0 0 0 4.179
    TESTI10000230 0 0 0 4.142
    TESTI20009700 0 0 0 15.218
    TESTI20040310 0 0 0 5.364
    THYMU10003290 0 0 0 34.388
    TRACH20013950 0 0 0 12.004
    BGGI120010970 0 0 2.974 0
    BNGH410001980 0 0 20.55 0
    BRACE10001660 0 0 11.3 0
    BRACE20014770 0 0 8.968 0
    BRACE20034490 0 0 6.108 0
    BRACE20071740 0 0 27.924 0
    BRAWH20009440 0 0 11.189 0
    BRAWH20036930 0 0 19.379 0
    CTONG20020730 0 0 25.686 0
    CTONG20028030 0 0 26.479 0
    FCBBF10006750 0 0 26.462 0
    FCBBF20012110 0 0 19.363 0
    FCBBF20015380 0 0 3.168 0
    FEBRA20007570 0 0 1.649 0
    FEBRA20043250 0 0 8.353 0
    FEBRA20068730 0 0 6.35 0
    HCASM10001150 0 0 1.43 0
    HCASM20002140 0 0 2.71 0
    HHDPC20000950 0 0 4.733 0
    HHDPC20004620 0 0 25.354 0
    HSYRA10001370 0 0 10.795 0
    HSYRA10001780 0 0 7.211 0
    HSYRA20001350 0 0 7.505 0
    HSYRA20006050 0 0 17.911 0
    IMR3210001580 0 0 5.369 0
    IMR3220002230 0 0 4.566 0
    IMR3220003020 0 0 4.387 0
    KIDNE20004030 0 0 3.815 0
    KIDNE20060300 0 0 1.994 0
    KIDNE20073280 0 0 6.225 0
    MESAN20005010 0 0 24.967 0
    NT2RI10000160 0 0 100 0
    NT2RI10000270 0 0 38.568 0
    NT2RI10000480 0 0 55.06 0
    NT2RI10001640 0 0 100 0
    NT2RI20002700 0 0 100 0
    NT2RI20002820 0 0 100 0
    NT2RI20003410 0 0 100 0
    NT2RI20004120 0 0 15.349 0
    NT2RI20005970 0 0 100 0
    NT2RI20006690 0 0 6.222 0
    NT2RI20006850 0 0 29.216 0
    NT2RI20007380 0 0 100 0
    NT2RI20008650 0 0 100 0
    NT2RI20010100 0 0 55.06 0
    NT2RI20010830 0 0 100 0
    NT2RI20010910 0 0 9.758 0
    NT2RI20012350 0 0 100 0
    NT2RI20012440 0 0 100 0
    NT2RI20014090 0 0 23.941 0
    NT2RI20015190 0 0 100 0
    NT2RI20015400 0 0 0.383 0
    NT2RI20016570 0 0 1.461 0
    NT2RI20017260 0 0 73.33 0
    NT2RI20018460 0 0 14.383 0
    NT2RI20018660 0 0 50.642 0
    NT2RI20020220 0 0 39.883 0
    NT2RI20020410 0 0 100 0
    NT2RI20021520 0 0 14.03 0
    NT2RI20022430 0 0 22.43 0
    NT2RI20022700 0 0 100 0
    NT2RI20025300 0 0 25.585 0
    NT2RI20025850 0 0 25.193 0
    NT2RI20026540 0 0 5.201 0
    NT2RI20028020 0 0 39.201 0
    NT2RI20028520 0 0 62.741 0
    NT2RI20029580 0 0 8.861 0
    NT2RI20029700 0 0 100 0
    NT2RI20030110 0 0 2.725 0
    NT2RI20030190 0 0 28.31 0
    NT2RI20030670 0 0 100 0
    NT2RI20031540 0 0 100 0
    NT2RI20032050 0 0 100 0
    NT2RI20032220 0 0 100 0
    NT2RI20033010 0 0 17.133 0
    NT2RI20033380 0 0 6.678 0
    NT2RI20033440 0 0 31.421 0
    NT2RI20033830 0 0 21.125 0
    NT2RI20036780 0 0 100 0
    NT2RI20041900 0 0 100 0
    NT2RI20042840 0 0 21.943 0
    NT2RI20043040 0 0 28.031 0
    NT2RI20043980 0 0 16.393 0
    NT2RI20044420 0 0 100 0
    NT2RI20047830 0 0 100 0
    NT2RI20048400 0 0 100 0
    NT2RI20049160 0 0 100 0
    NT2RI20049840 0 0 51.095 0
    NT2RI20049850 0 0 17.16 0
    NT2RI20050610 0 0 34.993 0
    NT2RI20050870 0 0 100 0
    NT2RI20056280 0 0 100 0
    NT2RI20056470 0 0 0.508 0
    NT2RI20058110 0 0 12.655 0
    NT2RI20060710 0 0 18.232 0
    NT2RI20060720 0 0 36.029 0
    NT2RI20061270 0 0 100 0
    NT2RI20061830 0 0 32.269 0
    NT2RI20062100 0 0 4.387 0
    NT2RI20063450 0 0 100 0
    NT2RI20064870 0 0 100 0
    NT2RI20065060 0 0 56.418 0
    NT2RI20065530 0 0 2.339 0
    NT2RI20066670 0 0 100 0
    NT2RI20066790 0 0 100 0
    NT2RI20067350 0 0 28.093 0
    NT2RI20067880 0 0 100 0
    NT2RI20068250 0 0 39.94 0
    NT2RI20068550 0 0 34.304 0
    NT2RI20070480 0 0 100 0
    NT2RI20070840 0 0 5.538 0
    NT2RI20070960 0 0 39.827 0
    NT2RI20071160 0 0 100 0
    NT2RI20071480 0 0 8.058 0
    NT2RI20072140 0 0 100 0
    NT2RI20072540 0 0 21.715 0
    NT2RI20073030 0 0 100 0
    NT2RI20073840 0 0 57.89 0
    NT2RI20073860 0 0 100 0
    NT2RI20074690 0 0 100 0
    NT2RI20075070 0 0 100 0
    NT2RI20077290 0 0 100 0
    NT2RI20077510 0 0 100 0
    NT2RI20077540 0 0 39.213 0
    NT2RI20078270 0 0 39.208 0
    NT2RI20078790 0 0 9.741 0
    NT2RI20078910 0 0 100 0
    NT2RI20080500 0 0 100 0
    NT2RI20081880 0 0 100 0
    NT2RI20082210 0 0 2.823 0
    NT2RI20083360 0 0 5.348 0
    NT2RI20085260 0 0 3.491 0
    NT2RI20085980 0 0 2.71 0
    NT2RI20086560 0 0 13.947 0
    NT2RI20087140 0 0 50.642 0
    NT2RI20087490 0 0 1.932 0
    NT2RI20088010 0 0 100 0
    NT2RI20088120 0 0 15.273 0
    NT2RI20090830 0 0 24.964 0
    NT2RI20091440 0 0 100 0
    NT2RI20092150 0 0 100 0
    NT2RI20092890 0 0 100 0
    NTONG10001820 0 0 8.461 0
    OCBBF20002770 0 0 39.883 0
    OCBBF20011240 0 0 7.83 0
    PEBLM10001440 0 0 18.541 0
    PLACE50001130 0 0 16.492 0
    PLACE60014430 0 0 3.227 0
    PROST20029600 0 0 40.276 0
    PUAEN10000570 0 0 8.916 0
    SALGL10001570 0 0 1.34 0
    SKMUS10000220 0 0 3.288 0
    SKMUS20004670 0 0 25.34 0
    STOMA20002890 0 0 1.705 0
    SYNOV10001280 0 0 4.538 0
    TESTI20012690 0 0 3.275 0
    TESTI20023690 0 0 44.022 0
    TESTI20028660 0 0 10.313 0
    TESTI20068720 0 0 21.478 0
    THYMU10000020 0 0 27.219 0
    THYMU10000830 0 0 8.95 0
    TRACH20002370 0 0 13.11 0
    3NB6910001290 0 9.099 0 0
    BRACE10000700 0 22.972 0 0
    BRACE20003320 0 14.937 0 0
    BRACE20015080 0 26.275 0 0
    BRACE20079020 0 59.759 0 0
    BRACE20083800 0 4.248 0 0
    BRACE20092740 0 42.609 0 0
    FEBRA20008810 0 9.264 0 0
    FEBRA20017150 0 30.227 0 0
    FEBRA20067930 0 58.409 0 0
    HHDPC20000550 0 14.432 0 0
    HSYRA20008280 0 7.137 0 0
    HSYRA20014760 0 5.313 0 0
    KIDNE10001450 0 19.263 0 0
    KIDNE20000850 0 4.841 0 0
    KIDNE20002660 0 7.078 0 0
    KIDNE20003300 0 20.763 0 0
    KIDNE20033050 0 1.709 0 0
    KIDNE20045340 0 17.723 0 0
    NT2RP60000080 0 100 0 0
    NT2RP60000170 0 100 0 0
    NT2RP60000320 0 100 0 0
    NT2RP60000390 0 100 0 0
    NT2RP60000590 0 100 0 0
    NT2RP60000860 0 100 0 0
    NT2RP60001000 0 100 0 0
    NT2RP60001230 0 5.146 0 0
    NT2RP60001270 0 100 0 0
    NT2RP70000410 0 100 0 0
    NT2RP70000690 0 66.955 0 0
    NT2RP70002590 0 31.56 0 0
    NT2RP70002710 0 14.558 0 0
    NT2RP70003640 0 100 0 0
    NT2RP70003910 0 100 0 0
    NT2RP70004250 0 100 0 0
    NT2RP70005790 0 100 0 0
    NT2RP70006240 0 100 0 0
    NT2RP70008120 0 100 0 0
    NT2RP70009060 0 8.617 0 0
    NT2RP70012310 0 24.404 0 0
    NT2RP70013060 0 49.874 0 0
    NT2RP70013350 0 30.221 0 0
    NT2RP70015910 0 22.4 0 0
    NT2RP70018560 0 100 0 0
    NT2RP70021510 0 49.439 0 0
    NT2RP70022430 0 33.36 0 0
    NT2RP70023760 0 17.87 0 0
    NT2RP70024490 0 22.701 0 0
    NT2RP70024500 0 19.57 0 0
    NT2RP70025540 0 100 0 0
    NT2RP70026190 0 9.482 0 0
    NT2RP70028290 0 49.972 0 0
    NT2RP70028410 0 100 0 0
    NT2RP70030500 0 100 0 0
    NT2RP70030910 0 20.809 0 0
    NT2RP70033040 0 100 0 0
    NT2RP70036290 0 9.965 0 0
    NT2RP70036470 0 24.999 0 0
    NT2RP70039600 0 15.306 0 0
    NT2RP70040800 0 100 0 0
    NT2RP70042040 0 9.773 0 0
    NT2RP70042330 0 60.574 0 0
    NT2RP70042600 0 71.279 0 0
    NT2RP70043730 0 7.505 0 0
    NT2RP70043960 0 100 0 0
    NT2RP70045410 0 24.679 0 0
    NT2RP70046560 0 100 0 0
    NT2RP70046870 0 100 0 0
    NT2RP70047510 0 100 0 0
    NT2RP70047660 0 100 0 0
    NT2RP70047900 0 18.549 0 0
    NT2RP70049250 0 27.784 0 0
    NT2RP70049750 0 100 0 0
    NT2RP70052050 0 64.358 0 0
    NT2RP70052190 0 100 0 0
    NT2RP70054680 0 100 0 0
    NT2RP70054930 0 49.38 0 0
    NT2RP70055130 0 3.248 0 0
    NT2RP70055200 0 19.133 0 0
    NT2RP70061620 0 100 0 0
    NT2RP70061880 0 20.642 0 0
    NT2RP70062960 0 100 0 0
    NT2RP70063040 0 100 0 0
    NT2RP70063740 0 100 0 0
    NT2RP70064080 0 100 0 0
    NT2RP70066210 0 100 0 0
    NT2RP70067010 0 100 0 0
    NT2RP70069800 0 40.229 0 0
    NT2RP70071140 0 33.145 0 0
    NT2RP70071540 0 49.972 0 0
    NT2RP70072210 0 100 0 0
    NT2RP70072520 0 100 0 0
    NT2RP70073590 0 100 0 0
    NT2RP70073810 0 100 0 0
    NT2RP70074060 0 100 0 0
    NT2RP70075040 0 100 0 0
    NT2RP70076100 0 36.014 0 0
    NT2RP70076170 0 100 0 0
    NT2RP70076430 0 100 0 0
    NT2RP70079250 0 100 0 0
    NT2RP70079300 0 71.279 0 0
    NT2RP70081330 0 100 0 0
    NT2RP70081370 0 26.129 0 0
    NT2RP70081420 0 100 0 0
    NT2RP70081440 0 100 0 0
    NT2RP70081670 0 100 0 0
    NT2RP70083150 0 100 0 0
    NT2RP70084060 0 100 0 0
    NT2RP70084410 0 65.611 0 0
    NT2RP70084870 0 48.444 0 0
    NT2RP70085500 0 100 0 0
    NT2RP70085570 0 9.069 0 0
    NT2RP70086230 0 100 0 0
    NT2RP70087200 0 100 0 0
    NT2RP70088550 0 15.625 0 0
    NT2RP70090120 0 49.497 0 0
    NT2RP70090190 0 100 0 0
    NT2RP70091490 0 49.38 0 0
    NT2RP70091680 0 100 0 0
    NT2RP70092150 0 100 0 0
    NT2RP70092360 0 100 0 0
    NT2RP70093630 0 100 0 0
    NT2RP70093700 0 100 0 0
    NT2RP70093940 0 24.073 0 0
    NT2RP70093970 0 100 0 0
    NT2RP70094290 0 100 0 0
    NT2RP70094660 0 100 0 0
    NT2RP70094810 0 58.409 0 0
    NT2RP70094980 0 44.133 0 0
    NT2RP70095020 0 100 0 0
    NT2RP70095070 0 100 0 0
    NTONG10000980 0 10.097 0 0
    NTONG10002140 0 12.777 0 0
    NTONG20002650 0 10.048 0 0
    NTONG20016120 0 21.562 0 0
    PEBLM20003950 0 8.711 0 0
    PROST10005640 0 10.708 0 0
    PROST20003250 0 24.163 0 0
    SKNMC20000650 0 3.384 0 0
    SKNSH10000860 0 23.605 0 0
    SKNSH20003470 0 15.832 0 0
    TESTI10000510 0 11.33 0 0
    TESTI10000960 0 51.106 0 0
    TESTI20015110 0 65.524 0 0
    TESTI20074640 0 12.147 0 0
    TRACH20004610 0 13.344 0 0
  • TABLE 5
    Clone ID BEAST TBAES
    3NB6910001730 0 33.793
    FCBBF10007600 0 75.606
    KIDNE20033050 0 40.478
    KIDNE20060300 0 69.585
    NT2RI20065530 0 81.65
    NT2RP60000720 0 69.448
    NT2RP70075370 0 57.062
    TRACH20004200 0 94.946
    LIVER10000670 68.212 0
    LIVER10005420 78.818 0
    LIVER20000370 73.799 0
  • TABLE 6
    Clone ID CERVX TCERX
    BRACE10001590 0 57.778
    HHDPC20000950 0 40.177
    HSYRA20016210 0 10.84
    NT2RI20074980 0 46.086
    3NB6920014330 69.325 0
    NT2RI20087490 33.161 0
    NT2RP60001090 80.827 0
    PROST10002200 42.592 0
    SKNMC20003220 58.42 0
    STOMA20001210 49.81 0
  • TABLE 7
    Clone ID COLON TCOLN
    BRACE20028610 0 95.142
    BRACE20011170 78.541 0
    BRACE20035940 95.04 0
    IMR3220013320 60.529 0
    NT2NE20053710 26.798 0
  • TABLE 8
    Clone ID NESOP TESOP
    KIDNE20005740 0 54.924
    MAMGL10000320 0 13.581
    NESOP10000870 49.196 0
    NT2RI20056470 69.766 0
    NTONG20008000 78.683 0
  • TABLE 9
    Clone ID KIDNE TKIDN
    3NB6920002810 0 1.507
    ADRGL10000020 0 12.08
    BNGH420004740 0 3.392
    BRACE10000200 0 33.823
    BRACE10000420 0 4.476
    BRACE10000730 0 35.7
    BRACE10001590 0 3.051
    BRACE20005650 0 55.211
    BRACE20016730 0 41.8
    BRACE20028120 0 21.571
    BRACE20077980 0 4.39
    BRACE20083800 0 15.501
    BRACE20083850 0 25.281
    BRAWH10001740 0 23
    BRAWH20036930 0 11.581
    BRAWH20064500 0 14.412
    BRAWH20064930 0 40.792
    CTONG20028030 0 15.825
    FCBBF20015380 0 17.038
    FEBRA20005360 0 7.956
    FEBRA20007570 0 2.956
    FEBRA20008740 0 4.47
    FEBRA20012270 0 24.184
    FEBRA20025250 0 20.688
    HSYRA20002480 0 3.392
    HSYRA20006400 0 4.833
    HSYRA20008280 0 2.894
    HSYRA20015740 0 9.842
    HSYRA20016210 0 2.862
    IMR3220009350 0 4.967
    LIVER10001110 0 25.88
    NT2NE20003920 0 3.741
    NT2NE20007630 0 18.497
    NT2NE20007870 0 6.961
    NT2RI20025410 0 21.344
    NT2RI20026540 0 4.662
    NT2RI20029580 0 15.887
    NT2RI20033380 0 23.947
    NT2RI20033830 0 12.625
    NT2RI20051500 0 4.126
    NT2RI20058110 0 7.563
    NT2RI20090650 0 3.609
    NT2RP60000720 0 3.567
    NT2RP70013350 0 9.191
    NT2RP70023790 0 2.777
    NT2RP70024490 0 27.614
    NT2RP70028750 0 3.807
    NT2RP70029060 0 11.18
    NT2RP70036800 0 7.976
    NT2RP70075370 0 2.931
    NT2RP70076100 0 14.603
    NTONG10000980 0 8.189
    NTONG10002460 0 4.695
    NTONG20015500 0 30.566
    OCBBF20002310 0 20.844
    OCBBF20013070 0 18.625
    PEBLM20001470 0 8.936
    PEBLM20003950 0 5.298
    PLACE60021510 0 12.663
    PLACE60040050 0 6.961
    PLACE60043970 0 7.802
    PROST20051430 0 37.542
    STOMA20001210 0 2.602
    STOMA20002570 0 14.983
    STOMA20002890 0 1.528
    SYNOV20011440 0 4.944
    TESTI10000230 0 4.9
    TESTI20009700 0 18.005
    TESTI20021490 0 8.135
    TESTI20032800 0 21.55
    TESTI20053960 0 9.979
    TESTI20080200 0 1.673
    TESTI20082400 0 2.876
    BGGI120010970 4.336 0
    BRACE20004210 3.583 0
    BRACE20005250 6.242 23.03
    BRACE20011170 3.303 0
    BRACE20020910 19.111 0
    BRACE20080970 20.33 0
    BRAWH20000340 10.476 0
    BRAWH20006970 3.96 0
    BRAWH20011660 5.897 0
    FCBBF20001950 65.363 0
    FEBRA20043250 12.177 0
    HLUNG10000640 23.921 0
    IMR3220007420 2.375 0
    IMR3220014350 4.092 0
    KIDNE10000080 22.13 0
    KIDNE10000280 100 0
    KIDNE10000500 15.868 0
    KIDNE10001040 100 0
    KIDNE10001430 100 0
    KIDNE10001450 19.052 0
    KIDNE10001520 100 0
    KIDNE20000410 100 0
    KIDNE20000510 100 0
    KIDNE20000700 100 0
    KIDNE20000850 4.788 0
    KIDNE20001670 100 0
    KIDNE20001920 100 0
    KIDNE20002440 37.565 0
    KIDNE20002450 100 0
    KIDNE20002660 7 0
    KIDNE20003150 100 0
    KIDNE20003300 20.536 0
    KIDNE20003490 64.026 5.625
    KIDNE20003750 100 0
    KIDNE20004030 5.561 0
    KIDNE20004220 35.77 0
    KIDNE20004970 12.49 0
    KIDNE20005130 100 0
    KIDNE20005170 81.524 0
    KIDNE20005190 100 0
    KIDNE20005740 2.3 0
    KIDNE20031850 16.193 0
    KIDNE20033050 3.381 0
    KIDNE20033350 100 0
    KIDNE20033570 53.825 0
    KIDNE20033730 100 0
    KIDNE20033770 100 0
    KIDNE20037520 100 0
    KIDNE20039410 100 0
    KIDNE20039940 43.968 0
    KIDNE20040340 100 0
    KIDNE20040540 49.114 0
    KIDNE20040840 100 0
    KIDNE20042620 100 0
    KIDNE20042940 100 0
    KIDNE20042950 100 0
    KIDNE20043440 100 0
    KIDNE20044110 7.51 0
    KIDNE20045200 100 0
    KIDNE20045340 17.53 0
    KIDNE20045790 100 0
    KIDNE20046810 100 0
    KIDNE20048280 100 0
    KIDNE20048640 34.264 0
    KIDNE20048790 100 0
    KIDNE20049810 100 0
    KIDNE20050420 35.626 0
    KIDNE20052960 100 0
    KIDNE20053360 58.142 0
    KIDNE20054000 49.697 0
    KIDNE20054770 100 0
    KIDNE20056290 100 0
    KIDNE20056760 16.262 0
    KIDNE20059080 100 0
    KIDNE20059370 88.03 0
    KIDNE20060140 13.852 0
    KIDNE20060300 2.906 0
    KIDNE20060530 100 0
    KIDNE20060620 100 0
    KIDNE20061490 100 0
    KIDNE20062990 31.685 0
    KIDNE20063530 26.747 0
    KIDNE20063760 100 0
    KIDNE20066520 70.185 0
    KIDNE20067600 100 0
    KIDNE20067750 8.487 0
    KIDNE20068800 24.137 0
    KIDNE20070050 66.711 0
    KIDNE20070770 100 0
    KIDNE20071860 39.822 0
    KIDNE20073280 4.537 0
    KIDNE20073520 8.83 3.62
    KIDNE20073560 100 0
    KIDNE20074220 100 0
    KIDNE20075690 100 0
    KIDNE20078100 100 0
    KIDNE20078110 100 0
    LIVER10000790 15.673 0
    MAMGL10000320 1.138 0
    NB9N410000470 3.598 0
    NT2NE20053710 1.127 0
    NT2RI20006710 2.454 0
    NT2RI20013420 2.015 0
    NT2RI20016570 23.435 0
    NT2RI20018460 20.967 0
    NT2RI20025540 5.573 0
    NT2RI20040590 13.676 0
    NT2RI20065530 3.41 0
    NT2RI20087490 1.408 0
    NT2RI20087910 2.824 0
    NT2RP60000350 5.311 0
    NT2RP60001230 5.09 0
    NT2RP70043730 14.846 0
    NT2RP70069860 10.745 26.431
    NT2RP70074220 3.96 0
    OCBBF20014940 49.164 0
    PLACE60020840 2.658 0
    PLACE60043120 3.992 9.82
    PROST10003430 25.547 0
    SKNSH20001510 20.208 0
    SMINT10000160 38.817 15.914
    SPLEN20000470 66.711 0
    SPLEN20001340 88.909 0
    SPLEN20003570 31.635 0
    STOMA10000470 17.849 0
    TESTI10000700 25.214 0
    TESTI20027070 14.795 0
    TESTI20040310 2.58 0
    TRACH10000300 11.119 0
    TRACH20000790 4.534 11.153
    TRACH20002500 35.282 0
    TRACH20007800 5.605 0
  • TABLE 10
    Clone ID LIVER TLIVE
    FCBBF50002610 0 88.758
    FEBRA20076220 0 53.946
    KIDNE20033050 0 40.878
    NT2NE20003840 0 70.165
    KIDNE20062480 7.391 0
    KIDNE20068800 60.015 0
    LIVER10000580 100 0
    LIVER10000670 31.788 0
    LIVER10000790 77.941 0
    LIVER10000990 100 0
    LIVER10001040 100 0
    LIVER10001110 52.319 0
    LIVER10001750 100 0
    LIVER10002300 66.114 0
    LIVER10002780 100 0
    LIVER10003030 100 0
    LIVER10004330 100 0
    LIVER10005420 13.604 0
    LIVER20000330 100 0
    LIVER20004160 33.27 0
    LIVER20004460 100 0
    LIVER20005150 100 0
    NT2NE20002140 27.596 0
    NT2RI20030510 18.459 0
    NT2RI20043040 50.8 0
    NT2RI20090650 7.296 0
    PROST10005640 26.335 0
    PROST20032320 15.404 0
    SALGL10001570 2.428 0
    SMINT10000160 32.172 0
    SPLEN20002420 83.286 0
    TESTI20002530 26.418 0
    TESTI20080200 3.383 0
    THYMU10003590 7.302 0
    TRACH20004720 6.356 0
  • TABLE 11
    Clone ID HLUNG TLUNG
    NT2RI20030110 0 94.571
    BNGH410001980 16.113 0
    BRACE10000420 7.831 0
    BRACE10001150 1.339 0
    BRACE20014770 28.126 0
    BRACE20018550 25.65 0
    BRAWH20006970 8.521 0
    BRAWH20014610 7.03 77.801
    FEBRA20008810 19.713 0
    FEBRA20015840 53.019 0
    FEBRA20044120 15.75 0
    HHDPC20001490 25.611 0
    HLUNG10000240 100 0
    HLUNG10000300 100 0
    HLUNG10000370 100 0
    HLUNG10000640 51.466 0
    HLUNG10000760 12.838 0
    HLUNG10000990 100 0
    HLUNG10001050 100 0
    HLUNG10001100 100 0
    HLUNG20000680 72.532 0
    HLUNG20001160 100 0
    HLUNG20001250 100 0
    HLUNG20001420 79.349 0
    HLUNG20001760 100 0
    HLUNG20002550 100 0
    HLUNG20003140 14.018 0
    HLUNG20004120 42.131 0
    HLUNG20004800 100 0
    HLUNG20005010 5.302 0
    HSYRA20014200 12.578 0
    KIDNE20002660 15.061 0
    KIDNE20033050 3.637 0
    NT2NE20014350 28.99 0
    NT2RI20016570 9.167 0
    NT2RI20026540 8.156 0
    NT2RI20051500 21.652 0
    NT2RI20064120 9.093 0
    NT2RI20083960 17.851 0
    NT2RI20085260 5.474 0
    NT2RI20087490 3.03 0
    NT2RP70009060 18.337 0
    NT2RP70011660 5.822 0
    NT2RP70029060 6.519 0
    NT2RP70055020 10.451 0
    NT2RP70074220 8.521 0
    NT2RP70076100 25.546 0
    NTONG10002460 16.426 0
    NTONG20008000 7.189 0
    PLACE60043120 8.589 0
    SKMUS20016340 15.317 0
    SKNMC20005930 13.727 0
    SMINT20000180 38.989 0
    SMINT20002390 51.283 0
    SMINT20002770 12.776 0
    SMINT20003960 10.489 0
    STOMA10000470 38.402 0
    STOMA20001880 52.43 0
    SYNOV20013740 23.798 0
    TESTI20036250 32.684 0
    TESTI20080200 2.927 0
    TRACH20004610 28.395 0
  • TABLE 12
    Clone ID NOVAR TOVAR
    BRACE20011880 0 93.107
    TESTI20030710 0 79.631
    BRACE20076210 97.13 0
    NT2RI20053680 78.467 0
    SKMUS20008630 61.727 0
    TESTI20005910 94.963 0
    TESTI20040310 59.442 0
  • TABLE 13
    Clone ID STOMA TSTOM
    HSYRA20011030 0 60.206
    NT2RI20013420 0 48.779
    NT2RP70079750 0 74.336
    BRACE20003320 28.838 0
    HEART20005060 8.996 0
    HHDPC20000950 3.367 0
    HLUNG20004120 38.225 0
    HLUNG20005010 4.81 0
    HSYRA20006400 23.013 0
    KIDNE10000500 30.974 0
    KIDNE20062480 2.901 0
    NT2NE20053710 2.2 0
    NT2NE20054410 65.251 0
    NT2RI20015400 0.544 0
    NT2RI20016570 4.159 0
    NT2RI20064120 8.25 0
    NT2RI20070840 15.758 0
    NT2RI20071330 13.128 0
    NT2RI20074980 3.862 0
    NT2RI20077230 20.833 0
    NT2RI20089420 17.218 0
    NT2RP70000760 4.442 0
    NT2RP70028750 3.021 0
    PLACE60014430 9.182 0
    PLACE60024190 54.046 0
    SKNMC20000970 4.463 0
    STOMA10000470 34.842 0
    STOMA10000520 100 0
    STOMA10001170 100 0
    STOMA10001330 100 0
    STOMA10001860 100 0
    STOMA20000320 100 0
    STOMA20000880 100 0
    STOMA20001210 4.129 0
    STOMA20001880 47.57 0
    STOMA20002570 23.78 0
    STOMA20002890 4.851 0
    STOMA20003960 100 0
    STOMA20004780 100 0
    STOMA20004820 28.859 0
    THYMU10003590 5.733 0
  • TABLE 14
    Clone ID UTERU TUTER
    NT2RI20085260 0 60.829
    3NB6920002810 1.339 0
    BRACE10000420 15.908 0
    BRACE20089990 28.795 0
    BRACE20092120 61.611 0
    BRAWH10001680 49.225 0
    BRAWH20011410 14.576 0
    BRAWH20011660 3.222 0
    FCBBF20005910 17.567 0
    FCBBF50002610 4.011 0
    FEBRA20005360 7.069 0
    FEBRA20006800 81.993 0
    FEBRA20008800 29.932 0
    FEBRA20044120 7.999 0
    FEBRA20057520 14.823 0
    HEART20005060 5.036 0
    HHDPC20000950 1.885 0
    HLUNG10000760 3.26 0
    HLUNG20003140 7.12 0
    HSYRA20014200 6.388 0
    HSYRA20014760 5.742 0
    HSYRA20015800 36.126 0
    IMR3210002420 7.465 0
    IMR3220002230 3.637 0
    IMR3220009350 4.412 0
    IMR3220014350 4.472 0
    IMR3220016000 0.788 0
    KIDNE20000850 5.232 0
    KIDNE20060140 15.135 0
    KIDNE20060300 3.176 0
    MAMGL10000350 1.122 0
    NT2NE20035690 11.316 0
    NT2NE20053710 1.232 0
    NT2RI10000270 61.432 0
    NT2RI20000640 3.308 0
    NT2RI20002940 19.984 0
    NT2RI20010910 15.542 0
    NT2RI20013420 2.201 0
    NT2RI20016570 2.328 0
    NT2RI20033380 10.637 0
    NT2RI20036950 5.07 0
    NT2RI20037510 2.677 0
    NT2RI20053350 2.517 0
    NT2RI20057230 2.613 0
    NT2RI20058110 6.719 0
    NT2RI20071480 25.67 0
    NT2RI20074980 4.324 0
    NT2RI20084810 20.5 0
    NT2RI20087490 1.539 0
    NT2RI20087910 12.345 0
    NT2RP60000350 1.451 0
    NT2RP70032030 4.778 0
    NT2RP70043730 8.111 0
    NTONG10000980 7.275 0
    NTONG10002460 4.171 0
    PLACE60014430 10.28 0
    PLACE60026680 15.19 0
    PLACE60043960 10.64 0
    PLACE60044910 52.136 0
    PLACE60047380 52.136 0
    PROST10002200 1.976 0
    PROST10005260 12.466 0
    PROST20025910 51.788 0
    PROST20033380 16.15 0
    PUAEN10000570 14.201 0
    SALGL10001570 1.067 0
    SKMUS10000140 23.507 0
    SKMUS20003430 35.091 0
    SKMUS20009540 9.414 0
    SKNMC10002510 6.618 0
    SKNMC20000970 2.498 0
    SKNSH10000860 25.511 0
    SMINT20002770 3.244 0
    STOMA20002890 2.716 0
    SYNOV20011440 4.393 0
    TESTI10000230 8.707 0
    TESTI20018290 12.741 0
    TESTI20021490 14.455 0
    TESTI20080200 2.973 0
    TESTI20082400 2.555 0
    TRACH10000300 12.149 0
    TRACH20002370 20.883 0
    TRACH20007800 12.248 0
    TRACH20012890 4.662 0
    UTERU10000770 100 0
    UTERU10000960 50.58 0
    UTERU10001600 100 0
    UTERU10001920 100 0
    UTERU20000470 100 0
    UTERU20003380 35.158 0
    UTERU20003930 100 0
    UTERU20004850 100 0
    UTERU20005410 33.583 0
    UTERU20005690 50.58 0
  • TABLE 15
    Clone ID NTONG CTONG
    3NB6910001160 0 6.048
    3NB6910001290 0 3.009
    3NB6910001730 0 0.944
    BNGH420004740 0 3.688
    BRACE20008850 0 15.357
    BRACE20020910 0 12.778
    BRACE20074010 0 5.637
    BRAWH20014840 0 5.251
    BRAWH20089560 0 21.778
    CTONG20003030 0 100
    CTONG20005890 0 39.66
    CTONG20007710 0 100
    CTONG20008270 0 18.957
    CTONG20011390 0 100
    CTONG20013200 0 19.93
    CTONG20013660 0 100
    CTONG20015330 0 100
    CTONG20018200 0 100
    CTONG20019110 0 48.152
    CTONG20019550 0 100
    CTONG20020730 0 25.035
    CTONG20021430 0 100
    CTONG20024180 0 100
    CTONG20024530 0 23.734
    CTONG20025580 0 57.263
    CTONG20027210 0 100
    CTONG20028030 0 8.603
    CTONG20028160 0 100
    CTONG20028200 0 55.786
    CTONG20029650 0 100
    CTONG20037820 0 100
    CTONG20047160 0 100
    CTONG20055530 0 38.023
    CTONG20064490 0 24.327
    FEBRA20003770 0 22.646
    FEBRA20004520 0 19.228
    FEBRA20007400 0 4.377
    FEBRA20007570 0 1.607
    FEBRA20012940 0 7.503
    FEBRA20021940 0 1.128
    FEBRA20044120 0 4.895
    HCASM10001150 0 1.394
    HHDPC20004560 0 18.986
    HLUNG20003140 0 4.356
    HSYRA20002480 0 3.688
    IMR3220009350 0 2.7
    IMR3220012180 0 3.684
    KIDNE20000850 0 1.601
    KIDNE20002660 0 9.361
    KIDNE20004220 0 23.916
    KIDNE20005740 0 1.538
    KIDNE20056760 0 21.746
    KIDNE20060140 0 9.261
    KIDNE20062480 0 2.981
    MESAN20000920 0 19.727
    MESAN20003370 0 17.82
    NHNPC20002060 0 4.429
    NT2NE10001850 0 39.142
    NT2NE20000560 0 8.845
    NT2NE20002140 0 7.421
    NT2NE20003270 0 27.905
    NT2NE20003840 0 1.94
    NT2NE20014350 0 4.505
    NT2NE20053710 0 3.014
    NT2RI20006690 0 12.129
    NT2RI20006710 0 1.64
    NT2RI20016570 0 1.424
    NT2RI20018660 0 49.358
    NT2RI20025300 0 49.872
    NT2RI20025410 0 11.603
    NT2RI20030190 0 27.593
    NT2RI20030510 0 9.928
    NT2RI20036950 0 6.205
    NT2RI20046060 0 12.778
    NT2RI20053350 0 4.621
    NT2RI20067350 0 27.381
    NT2RI20075720 0 8.573
    NT2RI20078790 0 3.165
    NT2RI20083960 0 5.548
    NT2RI20087140 0 49.358
    NT2RI20094060 0 8.828
    NT2RP60000350 0 5.327
    NT2RP60001230 0 6.806
    NT2RP70000760 0 12.173
    NT2RP70004770 0 36.51
    NT2RP70009060 0 5.699
    NT2RP70011660 0 5.428
    NT2RP70023760 0 11.817
    NT2RP70023790 0 3.02
    NT2RP70024500 0 12.942
    NT2RP70026190 0 12.541
    NT2RP70029820 0 10.391
    NT2RP70036470 0 33.064
    NT2RP70043730 0 4.963
    NT2RP70061880 0 27.302
    NT2RP70071770 0 18.778
    NT2RP70076100 0 7.939
    NT2RP70079750 0 4.105
    NT2RP70084870 0 32.036
    NT2RP70093730 0 19.806
    OCBBF20013070 0 5.063
    PEBLM20003950 0 5.761
    PLACE60037450 0 33.178
    PLACE60043120 0 2.669
    PROST10003430 0 34.162
    PROST10005260 0 7.628
    PROST20032320 0 8.285
    PROST20033020 0 6.218
    PROST20056040 0 29.772
    SKNMC10002510 0 8.098
    SKNMC20000650 0 4.476
    SKNMC20010570 0 4.712
    SKNSH20003470 0 10.47
    SMINT20000180 0 24.233
    SYNOV20013740 0 7.396
    TESTI10000230 0 7.991
    TESTI10001680 0 8.412
    TESTI20007840 0 17.514
    TESTI20021490 0 4.422
    TESTI20022230 0 62.139
    TESTI20023690 0 42.906
    TESTI20030050 0 1.535
    TESTI20042950 0 76.649
    TESTI20068720 0 10.467
    TESTI20080200 0 0.91
    TRACH20012890 0 1.426
    BRACE20006980 55.471 0
    BRACE20092740 22.273 0
    BRAWH20006970 8.372 0
    FCBBF10007600 6.676 0
    FEBRA20062700 19.42 6.142
    IMR3220016000 3.049 0.482
    KIDNE20073280 9.592 3.034
    MAMGL10000350 2.171 0
    NT2NE20035690 21.893 0
    NT2RI20056470 23.487 5.448
    NT2RI20058110 12.999 0
    NT2RI20084810 13.22 0
    NT2RI20085260 5.378 0
    NT2RP70015910 46.836 14.813
    NT2RP70036290 20.836 59.311
    NT2RP70036320 18.528 46.879
    NT2RP70074220 8.372 0
    NT2RP70075370 5.038 0
    NTONG10000330 100 0
    NTONG10000520 44.434 0
    NTONG10001230 100 0
    NTONG10001300 100 0
    NTONG10001820 39.112 0
    NTONG10002140 80.147 0
    NTONG10002460 8.07 0
    NTONG10002570 100 0
    NTONG10002640 67.153 0
    NTONG20002650 21.01 6.645
    NTONG20003340 27.701 0
    NTONG20003630 100 0
    NTONG20004920 100 0
    NTONG20005830 100 0
    NTONG20008000 14.128 0
    NTONG20008780 100 0
    NTONG20009660 100 0
    NTONG20009850 100 0
    NTONG20011370 100 0
    NTONG20012220 100 0
    NTONG20014280 76.302 0
    NTONG20015500 52.537 0
    NTONG20016120 45.084 0
    OCBBF20011240 24.128 0
    OCBBF20015860 50.483 0
    PROST10002200 22.942 1.209
    SKMUS20016340 15.05 4.76
    SKNMC20000970 4.833 1.529
    STOMA20004820 31.253 9.885
    SYNOV10001280 13.986 0
    SYNOV20011440 8.499 0
    THYMU10000830 27.581 0
    TRACH20000790 19.169 0
    TRACH20009260 30.323 9.59
  • TABLE 16
    Clone ID FCBBF FEBRA OCBBF BRACE BRALZ BRAMY BRAWH BRCAN BRCOC BRHIP BRSSN BRSTN BRTHA
    BRACE- 0 0 0 37.659 0 0 62.341 0 0 0 0 0 0
    20028960
    BRACE- 0 0 0 17.222 8.739 16.608 28.509 5.549 8.568 5.733 0 0 0
    20074010
    BRACE- 0 0 0 8.944 0 0 14.807 17.29 26.699 0 0 0 0
    20077080
    BRACE- 0 0 0 7.291 7.4 2.344 8.046 9.396 3.627 4.854 19.055 18.412 0
    20077980
    BRACE- 0 0 0 2.86 8.709 8.275 4.735 11.059 12.807 5.713 4.485 17.335 0
    20083800
    BRACE- 0 0 0 24.099 0 0 39.894 0 0 0 0 0 0
    20088570
    BRAWH- 0 0 0 0 15.441 0 33.582 9.804 15.139 10.129 15.905 0 0
    10000010
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    10000020
    BRAWH- 0 0 0 0 0 0 34.097 0 0 0 0 0 0
    10000070
    BRAWH- 0 0 0 0 0 0 34.637 0 0 0 0 0 0
    10000370
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    10000940
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    10001300
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    10001640
    BRAWH- 0 0 0 0 0 0 50.775 0 0 0 0 0 0
    10001680
    BRAWH- 0 0 0 0 0 0 21.077 36.92 19.003 0 0 0 0
    10001740
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    10001800
    BRAWH- 0 0 0 0 0 0 11.808 0 10.646 0 0 0 0
    20000340
    BRAWH- 0 0 0 0 0 0 11.808 0 10.646 0 0 0 0
    20000340
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20000480
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20000930
    BRAWH- 0 0 0 0 0 0 11.171 6.522 0 6.739 0 0 0
    20001770
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20002480
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20003230
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20004430
    BRAWH- 0 0 0 0 0 0 62.374 0 0 37.626 0 0 0
    20004760
    BRAWH- 0 0 0 0 0 0 32.294 0 0 38.962 0 0 0
    20005030
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20005540
    BRAWH- 0 0 0 0 0 3.43 5.888 0 0 0 0 0 0
    20006330
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20006510
    BRAWH- 0 0 0 0 8.209 0 8.927 2.606 12.073 2.693 8.456 8.171 0
    20006970
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20008660
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20008920
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20009010
    BRAWH- 0 0 0 0 0 0 18.383 0 0 0 0 0 0
    20009440
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20009840
  • TABLE 17
    BRAWH- 0 0 0 0 0 0 69.012 0 0 0 0 0 0
    20011030
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20011290
    BRAWH- 0 0 0 0 0 1.936 3.323 0 0 0 0 3.042 0
    20011660
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20012030
    BRAWH- 0 0 0 14.525 11.056 7.004 24.046 7.02 10.84 14.505 0 11.004 0
    20014180
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20014380
    BRAWH- 0 0 0 0 0 2.145 3.683 0 0 0 0 0 9.34
    20014610
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20015030
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20036890
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20038320
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20047310
    BRAWH- 0 0 0 0 0 0 63.136 36.864 0 0 0 0 0
    20059980
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20060440
    BRAWH- 0 0 0 0 0 0 37.381 21.826 0 0 0 0 0
    20064930
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20066220
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20069600
    BRAWH- 0 0 0 27.609 0 0 45.705 26.686 0 0 0 0 0
    20069890
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20074060
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20076050
    BRAWH- 0 0 0 0 0 0 36.711 0 0 0 0 0 0
    20089560
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20092270
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20092610
    BRAWH- 0 0 0 0 0 0 32.978 0 29.733 0 0 0 0
    20093600
    BRAWH- 0 0 0 0 0 0 100 0 0 0 0 0 0
    20094850
    IMR32- 0 0 0 5.763 6.58 0 2.385 1.393 0 0 0 15.282 0
    20013170
    KIDNE- 0 0 0 1.63 0 0 2.698 0 0 0 2.556 0 0
    20000850
    KIDNE- 0 0 0 0 0 0 40.315 0 0 0 0 0 0
    20004220
    KIDNE- 0 0 0 0 0 0 9.125 0 0 0 0 0 46.286
    20031850
    KIDNE- 0 0 0 0 0 0 40.153 0 0 24.222 0 0 0
    20050420
    MAMGL- 0 0 0 0 0 0 1.157 0 0 0 0 0 0
    10000350
    NT2NE- 0 0 0 2.567 0 0 4.249 2.481 3.831 0 8.049 0 0
    20001740
    NT2RI- 0 0 0 0 0 42.005 36.052 0 0 0 0 0 0
    20042840
    NT2RI- 0 0 0 0 0 0 22.915 0 0 0 0 0 0
    20086560
    NT2RP- 0 0 0 0 0 0 35.182 20.542 0 0 0 0 0
    70002590
    NT2RP- 0 0 0 0 0 0 1.855 0 0 1.119 0 0 0
    70065270
    NT2RP- 0 0 0 0 8.209 0 8.927 2.606 12.073 2.693 8.456 8.171 0
    70074220
  • TABLE 18
    NTONG- 0 0 0 0 0 0 6.951 0 6.267 4.193 0 6.362 0
    10001820
    PEBLM- 0 0 0 0 0 19.082 8.189 0 0 9.88 0 0 0
    20001470
    PLACE- 0 0 0 0 0 0 35.969 0 0 0 0 0 0
    60032040
    SKMUS- 0 0 0 0 0 0 24.247 0 0 0 0 0 0
    10000140
    SMINT- 0 0 0 0 0 0 22.035 0 0 0 0 0 0
    20005450
    TESTI- 0 0 0 0 0 0 44.17 0 0 0 0 0 0
    20004350
    TESTI- 0 0 0 0 0 0 20.762 0 18.719 0 0 38.006 0
    20008830
    TRACH- 0 0 0 0 0 3.68 6.317 0 5.695 0 0 0 0
    20007800
    TRACH- 0 0 0 0 0 11.565 19.852 0 0 0 0 0 0
    20016070
    UMVEN- 0 0 0 0 0 0 3.329 0 0 0 0 0 0
    20001330
    3NB69- 0 0 0 0 2.926 0 0 0 0 0.96 0 1.456 0
    10001730
    3NB69- 0 0 0 0 0 0.805 0 1.613 1.245 0.833 0 0 0
    20002810
    ADRGL- 0 0 0 0 0 19.598 0 0 0 0 0 30.792 0
    20000740
    BNGH4- 0 0 0 0 0 15.04 0 0 0 0 0 0 0
    10001370
    BNGH4- 0 0 0 0 0 0 0 0 0 0 0 15.451 0
    10001980
    BRACE- 0 0 0 18.724 0 0 0 0 0 0 0 0 0
    10000200
    BRACE- 0 0 0 19.762 15.042 0 0 0 29.495 0 0 0 0
    10000730
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    10000930
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20000770
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20001000
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20001410
    BRACE- 0 0 0 28.46 0 0 0 0 0 28.42 0 43.121 0
    20002800
    BRACE- 0 0 0 10.059 0 0 0 0 0 0 0 0 0
    20003320
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20005050
    BRACE- 0 0 0 12.749 6.469 0 0 8.215 6.342 8.487 6.664 0 0
    20005250
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20005450
    BRACE- 0 0 0 15.282 0 14.737 0 14.771 0 0 0 0 0
    20005650
    BRACE- 0 0 0 15.282 0 14.737 0 14.771 0 0 0 0 0
    20005650
    BRACE- 0 0 0 62.564 0 0 0 0 0 0 0 0 0
    20005770
    BRACE- 0 0 0 17.865 0 0 0 0 26.664 0 0 0 0
    20006980
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20007180
    BRACE- 0 0 0 15.638 0 0 0 0 0 0 0 0 0
    20008850
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20009880
    BRACE- 0 0 0 16.902 51.46 0 0 0 0 0 0 0 0
    20010650
    BRACE- 0 0 0 38.94 0 0 0 0 0 0 61.06 0 0
    20010700
    BRACE- 0 0 0 2.249 3.424 0 0 0 0 0 0 0 0
    20011170
  • TABLE 19
    BRACE- 0 0 0 23.186 0 0 0 0 0 0 0 0 0
    20011430
    BRACE- 0 0 0 23.186 0 0 0 0 0 0 0 0 0
    20011430
    BRACE- 0 0 0 2.733 4.16 0 0 0 0 0 0 0 0
    20011880
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20013400
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20013520
    BRACE- 0 0 0 50.907 0 49.093 0 0 0 0 0 0 0
    20013740
    BRACE- 0 0 0 24 0 0 0 0 0 0 0 0 0
    20013750
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20014230
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20014530
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20014550
    BRACE- 0 0 0 8.901 0 0 0 0 0 8.888 0 0 0
    20014770
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20014920
    BRACE- 0 0 0 17.694 0 0 0 0 0 0 0 0 0
    20015080
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20015430
    BRACE- 0 0 0 23.14 0 0 0 0 0 0 0 35.06 0
    20016730
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20016920
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20017370
    BRACE- 0 0 0 8.117 0 0 0 0 0 0 0 0 0
    20018550
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20018590
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20018650
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20018980
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20021510
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20021760
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20022020
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20022270
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20024090
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20024090
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20024310
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20024680
    BRACE- 0 0 0 39.759 0 0 0 0 0 0 0 60.241 0
    20024950
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20025900
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20026350
    BRACE- 0 0 0 23.391 0 0 0 0 0 0 0 0 0
    20026850
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20027360
    BRACE- 0 0 0 29.06 0 0 0 0 0 0 0 0 0
    20027520
    BRACE- 0 0 0 34.821 0 0 0 0 0 0 0 0 0
    20027550
  • TABLE 20
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20027720
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20027920
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20027960
    BRACE- 0 0 0 59.705 0 0 0 0 0 0 18.724 0 0
    20028120
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20028600
    BRACE- 0 0 0 39.759 0 0 0 0 0 0 0 60.241 0
    20030780
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20032850
    BRACE- 0 0 0 23.804 0 0 0 0 0 0 0 0 0
    20033190
    BRACE- 0 0 0 39.646 60.354 0 0 0 0 0 0 0 0
    20033980
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20034310
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20035160
    BRACE- 0 0 0 2.721 0 0 0 0 0 0 0 0 0
    20035940
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20071380
    BRACE- 0 0 0 50.85 0 0 0 49.15 0 0 0 0 0
    20071530
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20071970
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20072010
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20072320
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20072810
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20074470
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20075020
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20075270
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20075380
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20075630
    BRACE- 0 0 0 2.87 0 0 0 0 0 0 0 0 0
    20076210
    BRACE- 0 0 0 50.907 0 49.093 0 0 0 0 0 0 0
    20076460
    BRACE- 0 0 0 75.026 0 0 0 0 0 24.974 0 0 0
    20076630
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20076850
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20077610
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20077640
    BRACE- 0 0 0 18.376 0 0 0 0 0 0 0 0 0
    20077670
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20077840
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20078680
    BRACE- 0 0 0 40.241 0 0 0 0 0 0 0 0 0
    20079020
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20079530
    BRACE- 0 0 0 13.841 0 0 0 0 20.658 0 0 0 0
    20080970
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20081140
  • TABLE 21
    BRACE- 0 0 0 13.995 0 0 0 0 20.888 0 0 21.205 0
    20083850
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20084430
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20084880
    BRACE- 0 0 0 24.161 0 0 0 0 0 0 0 0 0
    20086530
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20086550
    BRACE- 0 0 0 56.896 0 0 0 0 0 0 0 43.104 0
    20087080
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20087540
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20089600
    BRACE- 0 0 0 17.942 0 0 0 0 0 0 0 0 0
    20089990
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20090140
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20091880
    BRACE- 0 0 0 38.389 0 0 0 0 0 0 0 0 0
    20092120
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20092750
    BRACE- 0 0 0 26.36 0 0 0 0 0 26.323 0 0 0
    20093070
    BRACE- 0 0 0 50.907 0 49.093 0 0 0 0 0 0 0
    20093110
    BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
    20094370
    CTONG- 0 0 0 0 0 0 0 0 0 0 0 0 81.043
    20008270
    CTONG- 0 0 0 0 0 0 0 0 0 0 31.824 0 0
    20013200
    CTONG- 0 0 0 0 0 0 0 49.28 0 0 0 0 0
    20020730
    CTONG- 0 0 0 0 0 0 0 0 36.973 0 0 0 0
    20064490
    HHDPC- 0 0 0 0 0 0 0 2.27 0 0 0 1.779 0
    20000950
    HHDPC- 0 0 0 0 0 7.181 0 0 0 0 0 0 0
    20001150
    HHDPC- 0 0 0 0 0 0 0 0 0 0 0 14.647 0
    20004560
    HSYRA- 0 0 0 0 0 6.902 0 0 0 14.294 0 0 0
    10001780
    HSYRA- 0 0 0 0 2.439 0 0 0 0 0 2.512 2.427 0
    20008280
    HSYRA- 0 0 0 0 19.869 0 0 0 0 0 0 0 0
    20011530
    IMR32- 0 0 0 0 0 0 0 0 0 12.063 0 0 0
    10002660
    IMR32- 0 0 0 0 0 0 0 0 0 4.348 0 0 0
    20003020
    IMR32- 0 0 0 0 0 0 0 0 0 5.491 12.933 0 0
    20009350
    KIDNE- 0 0 0 0 0 0 0 0 0 0 0 0 58.701
    20003300
    KIDNE- 0 0 0 0 0 0 0 0 0 0 0 0 35.702
    20004970
    KIDNE- 0 0 0 0 0 0 0 0 0 18.476 0 0 0
    20005170
    KIDNE- 0 0 0 0 0 0 0 0 0 11.97 0 0 0
    20059370
    KIDNE- 0 0 0 0 0 15.848 0 0 0 0 0 0 0
    20068800
    KIDNE- 0 0 0 0 0 0 0 0 0 3.085 0 0 0
    20073280
    LIVER- 0 0 0 0 0.637 0 0 0 0 0 0 0 0
    20000370
  • TABLE 22
    MESAN- 0 0 0 30.348 0 0 0 0 0 0 0 0 0
    20002670
    NT2NE- 0 0 0 0 0 38.711 0 0 0 0 0 0 0
    20005170
    NT2NE- 0 0 0 0 40.251 0 0 0 0 0 0 0 0
    20011560
    NT2NE- 0 0 0 0 0 0 0 0 0 0 50.666 0 0
    20013640
    NT2NE- 0 0 0 0 0 38.711 0 0 0 0 0 0 0
    20016970
    NT2RI- 0 0 0 0 0 1.611 0 0 0 0 2.619 0 0
    20006710
    NT2RI- 0 0 0 0 0 0 0 9.103 0 0 0 0 0
    20009740
    NT2RI- 0 0 0 0 0 21.469 0 0 0 0 0 0 0
    20022430
    NT2RI- 0 0 0 0 0 0 0 24.543 0 0 0 0 0
    20025300
    NT2RI- 0 0 0 0 0 37.52 0 0 0 0 0 0 0
    20028020
    NT2RI- 0 0 0 0 0 0 0 0 0 0 0 27.171 0
    20029260
    NT2RI- 0 0 0 2.704 0 0 0 0 0 0 0 0 0
    20030110
    NT2RI- 0 0 0 0 0 0 0 0 7.544 0 0 0 0
    20030510
    NT2RI- 0 0 0 0 14.174 0 0 0 0 0 0 0 0
    20040590
    NT2RI- 0 0 0 6.506 0 0 0 0 0 0 0 0 0
    20046060
    NT2RI- 0 0 0 0 0 48.905 0 0 0 0 0 0 0
    20049840
    NT2RI- 0 0 0 0 25.927 16.425 0 0 0 0 0 0 0
    20049850
    NT2RI- 0 0 0 0 0 0 0 0 0 0 0.791 0 0
    20056470
    NT2RI- 0 0 0 0 0 0 0 34.563 0 0 0 0 0
    20060720
    NT2RI- 0 0 0 0 0 0 0 0 0 4.348 0 0 0
    20062100
    NT2RI- 0 0 0 0 0 0 0 0 0 27.843 0 0 0
    20067350
    NT2RI- 0 0 0 0 0 0 0 0 0 0 0 60.06 0
    20068250
    NT2RI- 0 0 0 0 0 0 0 0 8.203 0 0 0 0
    20070840
    NT2RI- 0 0 0 0 60.173 0 0 0 0 0 0 0 0
    20070960
    NT2RI- 0 0 0 0 0 7.713 0 0 0 0 0 0 33.576
    20071480
    NT2RI- 0 0 0 0 0 0 0 20.831 0 0 0 0 0
    20072540
    NT2RI- 0 0 0 0 0 0 0 0 0 0 0 0 5.656
    20074980
    NT2RI- 0 0 0 0 0 0 0 0 0 1.73 0 0 0
    20085260
    NT2RI- 0 0 0 0 0 14.618 0 0 0 0 0 22.966 0
    20088120
    NT2RI- 0 0 0 5.633 0 0 0 5.445 0 11.251 0 0 0
    20090660
    NT2RI- 0 0 0 0 0 23.893 0 0 0 0 0 0 0
    20090830
    NT2RP- 0 0 0 0 0 0 0 0 50.126 0 0 0 0
    70013060
    NT2RP- 0 0 0 0 0 0 0 19.67 22.78 10.161 7.978 0 0
    70013350
    NT2RP- 0 0 0 0 0 0 0 0 0 0 0 0 50.521
    70023760
    NT2RP- 0 0 0 0 0 0 0 0 0 26.32 0 0 0
    70024500
    NT2RP- 0 0 0 0 0 0 0 0 0 6.997 21.973 0 0
    70030910
  • TABLE 23
    NT2RP- 0 0 0 0 0 5.755 0 0 0 5.959 0 0 0
    70036320
    NT2RP- 0 0 0 0 0 0 0 0 25.125 16.811 0 0 0
    70036470
    NT2RP- 0 0 0 0 0 0 0 39.426 0 0 0 0 0
    70042330
    NT2RP- 0 0 0 0 50.62 0 0 0 0 0 0 0 0
    70054930
    NT2RP- 0 0 0 0 0 0 0 0 0 0 0 33.469 0
    70064900
    NT2RP- 0 0 0 0 0 0 0 0 16.656 0 0 0 0
    70071140
    NT2RP- 0 0 0 0 0 0 0 0 0 3.241 0 0 0
    70075370
    NT2RP- 0 0 0 8.084 0 0 0 7.814 0 0 0 0 0
    70076100
    NT2RP- 0 0 0 6.271 0 2.016 0 0 0 0 0 0 0
    70079750
    NT2RP- 0 0 0 0 0 0 0 0 0 0 0 0 73.871
    70081370
    NT2RP- 0 0 0 0 0 0 0 0 0 0 0 50.503 0
    70090120
    NT2RP- 0 0 0 0 50.62 0 0 0 0 0 0 0 0
    70091490
    NT2RP- 0 0 0 0 0 19.45 0 0 0 0 0 0 0
    70093730
    NTONG- 0 0 0 0 0 23.698 0 0 0 0 0 0 0
    20014280
    NTONG- 0 0 0 0 0 0 0 0 0 16.897 0 0 0
    20015500
    PEBLM- 0 0 0 0 0 23.344 0 0 0 0 0 0 0
    10000340
    PLACE- 0 0 0 0 0 0 0 0 0 3.198 0 0 0
    60014430
    PLACE- 0 0 0 0 0 0 0 0 0 1.807 0 0 0
    60020840
    PLACE- 0 0 0 0 0 18.179 0 0 0 0 0 0 0
    60024190
    PLACE- 0 0 0 0 0 39.559 0 0 0 0 0 0 0
    60026920
    PLACE- 0 0 0 0 0 31.763 0 0 0 0 0 0 0
    60030380
    PLACE- 0 0 0 0 0 0 0 0 0 0 0 33.856 0
    60038500
    PLACE- 0 0 0 0 13.149 0 0 8.349 12.892 0 6.772 0 0
    60043970
    PROST- 0 0 0 40.095 0 0 0 0 0 0 0 0 0
    10002720
    PROST- 0 0 0 0 11.605 0 0 0 0 0 0 0 0
    20000530
    PROST- 0 0 0 0 0 39.227 0 0 0 0 0 0 0
    20021620
    PROST- 0 0 0 8.436 0 4.068 0 0 6.295 8.424 6.614 0 0
    20032320
    PROST- 0 0 0 40.252 0 0 0 9.726 0 0 0 0 0
    20033380
    PROST- 0 0 0 0 0 0 0 0 0 13.599 0 0 0
    20062600
    SALGL- 0 0 0 0 0 0 0 0 0 0 0 1.103 0
    10000050
    SALGL- 0 0 0 0 0 0 0 0 0 0 1.042 0 0
    10001570
    SKMUS- 0 0 0 3.263 0 0 0 6.308 9.741 0 5.117 0 0
    10000220
    SKMUS- 0 0 0 0 33.898 0 0 0 0 0 0 0 0
    20001170
    SKMUS- 0 0 0 14.288 0 0 0 0 0 0 0 43.297 0
    20002710
    SKMUS- 0 0 0 5.866 0 0 0 5.67 0 0 9.198 8.888 0
    20009540
    SKMUS- 0 0 0 0 0 17.838 0 0 0 0 0 0 0
    20011290
  • TABLE 24
    SKMUS- 0 0 0 11.766 0 0 0 0 0 0 0 0 0
    20015010
    SKMUS- 0 0 0 25.198 0 0 0 0 0 0 0 0 0
    20015430
    SKMUS- 0 0 0 0 7.379 0 0 0 7.234 0 0 0 0
    20016340
    SKNMC- 0 0 0 0 0 4.105 0 0 0 0 0 0 0
    20002240
    SKNMC- 0 0 0 0 0 6.882 0 0 0 0 0 5.406 0
    20015030
    SKNSH- 0 0 0 27.517 0 0 0 0 0 0 0 0 0
    20001510
    SMINT- 0 0 0 0 0 39.345 0 0 0 0 0 0 0
    10001000
    SMINT- 0 0 0 0 0 0 0 0 0 0 0 24.589 0
    20002390
    SPLEN- 0 0 0 0 0 0 0 0 0 0 0 0 85.137
    20001970
    STOMA- 0 0 0 0 0 0 0 0 0 0 0 0 6.046
    20001210
    STOMA- 0 0 0 0 0 0 0 0 0 0 13.006 0 0
    20002570
    SYNOV- 0 0 0 0 0 0 0 0 0 44.213 0 0 0
    20002910
    SYNOV- 0 0 0 2.737 0 0 0 0 0 0 12.876 4.147 11.491
    20011440
    TESTI- 0 0 0 0 0 0 0 0 0 7.619 0 0 0
    10000510
    TESTI- 0 0 0 0 0 16.555 0 0 0 17.143 0 0 0
    10000700
    TESTI- 0 0 0 0 0 8.261 0 0 0 0 0 0 0
    10001680
    TESTI- 0 0 0 0 0 0 0 0 0 0 0 38.108 0
    20005200
    TESTI- 0 0 0 0 0 21.276 0 0 0 0 0 0 0
    20015110
    TESTI- 0 0 0 0 0 0 0 7.673 0 0 0 0 0
    20018290
    TESTI- 0 0 0 0 0 0 0 61.764 0 0 0 0 0
    20018690
    TESTI- 0 0 0 0 0 0 0 0 0 62.532 0 0 0
    20018980
    TESTI- 0 0 0 0 0 0 0 0 0 0 0 25.049 0
    20024670
    TESTI- 0 0 0 11.93 36.321 0 0 23.061 0 0 0 0 0
    20032800
    TESTI- 0 0 0 18.795 0 0 0 0 0 0 0 0 0
    20033250
    TESTI- 0 0 0 0 0 0 0 0 0 0 16.219 0 0
    20036250
    TESTI- 0 0 0 0 0 0 0 61.764 0 0 0 0 0
    20136910
    THYMU- 0 0 0 0 0 8.566 0 0 0 0 0 0 0
    10000830
    THYMU- 0 0 0 0 0 0 0 0 33.614 0 0 0 0
    10003290
    THYMU- 0 0 0 0 0 0 0 0 0 0 0 3.029 0
    10003590
    UTERU- 0 0 0 0 0 0 0 0 0 0 49.42 0 0
    10000960
    UTERU- 0 0 0 0 0 0 0 0 0 0 49.42 0 0
    20005690
    ADRGL- 48.889 0 0 0 0 0 0 0 0 0 0 0 0
    10000650
    BGGI1- 2.298 0 0 0 0 2.847 0 0 0 0 0 0 0
    20010970
    BRACE- 1.899 0 0 2.44 0 0 0 0 0 0 0 0 0
    20004210
    BRACE- 9.224 0 0 23.701 0 0 0 11.454 17.687 0 0 0 0
    20020500
    BRACE- 10.127 0 0 13.011 0 0 0 0 0 0 0 0 0
    20020910
  • TABLE 25
    BRACE- 28.014 0 0 71.986 0 0 0 0 0 0 0 0 0
    20024780
    BRACE- 2.126 0 0 2.732 0 0 0 0 0 0 0 0 0
    20028610
    BRACE- 43.768 0 0 56.232 0 0 0 0 0 0 0 0 0
    20031100
    BRACE- 9.11 0 0 11.704 0 0 0 5.656 0 0 9.176 0 0
    20035270
    BRACE- 13.023 0 0 16.732 0 0 0 0 0 0 0 0 70.246
    20035390
    BRACE- 21.571 0 0 27.714 0 0 0 0 0 0 0 0 0
    20071740
    BRACE- 23.581 0 0 30.297 46.122 0 0 0 0 0 0 0 0
    20077270
    BRAWH- 31.981 0 0 0 0 0 68.019 0 0 0 0 0 0
    20001090
    CTONG- 18.811 0 0 0 0 0 0 0 0 0 0 0 0
    20024530
    CTONG- 44.214 0 0 0 0 0 0 0 0 0 0 0 0
    20028200
    CTONG- 30.136 0 0 0 0 0 0 0 0 0 0 0 0
    20055530
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    10005980
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    10006180
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    10006870
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    10006910
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    10007320
    FCBBF- 8.367 0 0 0 0 0 3.559 0 0 0 0 0 0
    10007600
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20000940
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20001050
    FCBBF- 34.637 0 0 0 0 0 0 0 0 0 0 0 0
    20001950
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20002320
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20002760
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20005760
    FCBBF- 8.519 0 0 0 0 0 0 0 0 0 0 0 0
    20005910
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20006770
    FCBBF- 33.171 0 0 0 0 0 0 0 0 0 66.829 0 0
    20007330
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20008080
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20008150
    FCBBF- 23.045 0 0 14.804 0 0 0 0 0 0 0 0 62.152
    20009400
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20009510
    FCBBF- 14.958 0 0 0 0 18.533 0 18.575 0 0 0 0 0
    20012110
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20012990
    FCBBF- 44.606 0 0 0 0 0 0 55.394 0 0 0 0 0
    20014800
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20016720
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20017180
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    20017200
  • TABLE 26
    FCBBF- 100 0 0 0 0 0 0 0 0 0 0 0 0
    40002820
    HCASM- 1.105 0 0 0 0 1.369 0 0 0 1.417 0 0 0
    10001150
    HHDPC- 6.308 0 0 8.105 0 0 0 0 0 0 0 0 0
    20001490
    HLUNG- 12.676 0 0 0 0 0 0 0 0 0 0 0 0
    10000640
    HLUNG- 6.906 0 0 0 0 4.278 7.344 8.576 0 0 0 6.722 0
    20003140
    HLUNG- 1.306 0 0 0 5.108 0 2.778 4.865 0 1.676 2.631 0 0
    20005010
    HSYRA- 5.798 0 0 0 0 7.183 0 0 0 7.438 0 0 0
    20001350
    HSYRA- 5.57 0 0 0 0 0 0 0 5.34 0 0 0 0
    20014760
    HSYRA- 20.226 0 0 0 0 0 0 0 0 0 0 0 0
    20016310
    IMR32- 1.259 0 0 1.617 7.386 0 0 0 0 0 0 0 0
    20007420
    IMR32- 1.911 0 0 0 0 0 0 0 0 0 0 0 0
    20009730
    IMR32- 5.075 0 0 0 0 0 0 0 0 0 0 0 0
    20009840
    IMR32- 2.92 0 0 3.752 0 0 0 0 0 0 0 5.685 0
    20012180
    IMR32- 1.349 0 0 3.466 0 0 0 0 0 0 0 2.626 0
    20013320
    KIDNE- 3.71 0 0 9.532 0 4.596 0 0 0 0 14.947 0 0
    20002660
    KIDNE- 25.852 0 0 0 0 0 0 0 0 0 0 0 0
    20056760
    KIDNE- 4.679 0 0 8.016 0 0 6.635 0 0 10.006 0 0 0
    20073520
    LIVER- 7.091 0 0 0 0 0 15.081 0 0 9.098 0 13.803 0
    20004160
    MESAN- 15.635 0 0 0 0 0 33.255 0 0 0 0 0 0
    20000920
    NT2NE- 11.539 0 0 0 0 0 0 0 0 0 0 0 0
    20015300
    NT2NE- 5.488 0 0 0 0 6.8 0 0 0 0 0 0 0
    20035690
    NT2RI- 7.537 0 0 0 0 0 0 0 0 0 0 0 0
    20010910
    NT2RI- 8.216 0 0 0 0 0 17.474 0 0 0 16.552 0 0
    20016210
    NT2RI- 1.129 0 0 0 0 0 0 0 2.165 0 0 0 0
    20016570
    NT2RI- 0.876 0 0 0 0 0 1.863 0 0 0 1.764 0 0
    20033040
    NT2RI- 24.272 0 0 0 0 0 0 0 0 0 0 0 0
    20033440
    NT2RI- 6.517 0 0 0 0 4.037 0 0 6.248 0 0 0 0
    20058110
    NT2RI- 43.582 0 0 0 0 0 0 0 0 0 0 0 0
    20065060
    NT2RI- 1.493 0 0 0 0 0 1.587 1.853 0 0 1.503 0 4.025
    20087490
    NT2RP- 1.537 0 0 0 0 0 0 0 2.947 0 0 0 0
    60000720
    NT2RP- 7.63 0 0 0 0 9.454 0 0 14.632 9.79 0 14.854 0
    70002710
    NT2RP- 51.164 0 0 0 0 0 0 0 0 0 0 0 0
    70012310
    NT2RP- 6.873 0 0 0 0 0 7.309 4.267 6.589 0 13.846 0 0
    70036800
    NT2RP- 2.574 0 0 0 0 0 5.475 0 0 0 0 0 0
    70055020
    NT2RP- 1.702 0 0 0 0 0 0 0 0 2.184 0 0 0
    70055130
    NT2RP- 10.819 0 0 0 0 0 0 0 0 0 0 0 0
    70061880
  • TABLE 27
    NT2RP- 34.389 0 0 0 0 0 0 0 0 0 0 0 0
    70084410
    PLACE- 2.922 0 0 0 0 0 0 0 0 3.749 0 0 15.76
    60037450
    PLACE- 10.959 0 0 0 0 0 0 0 0 0 0 0 0
    60049310
    PROST- 6.046 0 0 0 0 0 12.858 7.508 0 0 0 0 0
    10005260
    PROST- 34.251 0 0 0 0 0 0 0 0 0 0 0 0
    20018230
    PROST- 16.176 0 0 0 0 0 0 0 0 0 0 0 0
    20051430
    SKMUS- 9.448 0 0 0 18.48 0 0 0 0 0 0 0 0
    20000740
    SKMUS- 11.578 0 0 0 0 0 0 0 0 0 0 0 0
    20011470
    SKNMC- 3.771 0 0 0 0 0 0 0 0 0 0 0 0
    20003560
    SKNSH- 19.559 0 0 0 0 0 0 0 0 0 0 0 0
    20001630
    SPLEN- 51.503 0 0 0 0 0 0 0 0 0 0 0 0
    10000490
    STOMA- 0.658 0 0 1.692 3.864 2.448 0 4.906 2.525 0.845 0 2.564 0
    20002890
    SYNOV- 5.862 0 0 0 0 0 0 0 0 0 0 0 0
    20013740
    TESTI- 21.79 0 0 0 0 0 0 0 0 27.957 0 0 0
    20011410
    TESTI- 32.749 0 0 42.075 0 0 0 0 0 0 0 0 0
    20033760
    TESTI- 6.367 0 0 0 0 0 0 0 0 0 0 0 0
    20074640
    TRACH- 11.784 0 0 0 0 0 12.532 0 0 0 0 0 0
    10000300
    TRACH- 6.119 0 0 0 0 7.582 0 0 0 0 0 0 0
    20013950
    3NB69- 0 2.236 0 2.115 1.073 0.68 0 0 0 0 2.211 2.136 0
    20003300
    3NB69- 0 2.076 0 7.854 0 0 0 0 0 0 3.079 0 0
    20009120
    ADRGL- 0 11.553 0 32.778 0 0 18.087 0 0 10.911 0 0 0
    10000180
    BRACE- 0 0.896 0 5.51 7.743 0.409 3.508 1.639 0 0 2.658 3.211 0
    10001150
    BRACE- 0 1.786 0 3.378 5.142 0 0 3.265 0 0 0 0 0
    10001590
    BRACE- 0 26.07 0 49.31 0 0 0 0 0 24.62 0 0 0
    10001690
    BRACE- 0 61.348 0 19.339 0 0 0 0 0 19.312 0 0 0
    20077680
    BRACE- 0 7.585 0 7.173 0 0 0 6.933 0 0 0 0 0
    20092740
    BRACE- 0 34.081 0 16.116 24.533 0 0 0 0 0 25.27 0 0
    20093610
    BRACE- 0 8.101 0 22.983 0 7.388 0 0 0 7.65 0 0 0
    20095170
    BRAWH- 0 9.604 0 27.247 0 0 15.035 0 0 0 0 0 0
    20011410
    BRAWH- 0 6.779 0 12.822 0 0 10.613 0 0 0 10.053 0 0
    20036930
    BRAWH- 0 8.436 0 0 0 0 52.827 7.711 0 0 0 0 0
    20064500
    BRAWH- 0 11.947 0 0 0 0 37.407 0 0 33.848 0 0 0
    20087060
    CTONG- 0 51.848 0 0 0 0 0 0 0 0 0 0 0
    20019110
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20000350
    FEBRA- 0 51.43 0 0 0 0 0 0 0 48.57 0 0 0
    20000530
    FEBRA- 0 26.32 0 0 0 0 0 0 0 0 0 0 0
    20001050
  • TABLE 28
    FEBRA- 0 2.84 0 0 0 0 0 0 0 0 0 0 0
    20001290
    FEBRA- 0 56.251 0 0 0 0 0 0 0 0 0 0 0
    20003110
    FEBRA- 0 61.348 0 19.339 0 0 0 0 0 19.312 0 0 0
    20003300
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20003780
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20003910
    FEBRA- 0 24.941 0 0 0 0 39.046 0 0 0 0 0 0
    20003970
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20003990
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20004040
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20004150
    FEBRA- 0 30.224 0 0 0 0 0 0 0 0 0 0 0
    20004540
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20004910
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20006560
    FEBRA- 0 18.007 0 0 0 0 0 0 0 0 0 0 0
    20006800
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20006900
    FEBRA- 0 27.886 0 0 0 0 0 12.745 0 0 0 0 0
    20007330
    FEBRA- 0 2.356 0 0 0 0 3.689 0 0 0 0 3.376 0
    20007400
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20007710
    FEBRA- 0 52.244 0 0 0 0 0 47.756 0 0 0 0 0
    20007720
    FEBRA- 0 11.14 0 10.535 0 30.48 0 0 15.724 0 0 0 0
    20007870
    FEBRA- 0 51.395 0 48.605 0 0 0 0 0 0 0 0 0
    20008090
    FEBRA- 0 46.91 0 0 0 0 0 0 0 0 0 0 0
    20008560
    FEBRA- 0 19.721 0 18.651 0 0 0 18.027 0 0 0 0 0
    20008800
    FEBRA- 0 6.596 0 0 0 0 0 0 0 0 0 0 0
    20008810
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20009590
    FEBRA- 0 27.255 0 0 0 0 0 0 0 0 0 0 0
    20009720
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20010930
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20011330
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20011460
    FEBRA- 0 42.467 0 0 0 0 0 0 19.98 13.369 0 0 0
    20012270
    FEBRA- 0 8.079 0 0 0 0 0 0 0 0 0 0 0
    20012940
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20013510
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20014870
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20015900
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20015910
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20017060
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20017900
  • TABLE 29
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20019890
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20020860
    FEBRA- 0 56.251 0 0 0 0 0 0 0 0 0 0 0
    20024290
    FEBRA- 0 52.244 0 0 0 0 0 47.756 0 0 0 0 0
    20024420
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20027270
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20027830
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20028820
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20028970
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20029080
    FEBRA- 0 51.395 0 48.605 0 0 0 0 0 0 0 0 0
    20030540
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20031550
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20033080
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20034290
    FEBRA- 0 52.244 0 0 0 0 0 47.756 0 0 0 0 0
    20037070
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20041100
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20041910
    FEBRA- 0 1.855 0 0 2.67 0 0 0 0 1.752 5.501 5.315 0
    20042240
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20042370
    FEBRA- 0 63.862 0 0 0 0 0 0 0 0 0 0 0
    20042930
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20043290
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20044430
    FEBRA- 0 76.687 0 0 0 23.313 0 0 0 0 0 0 0
    20044900
    FEBRA- 0 40.275 0 0 0 0 0 0 0 0 59.725 0 0
    20045920
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20048180
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20050140
    FEBRA- 0 68.681 0 0 0 31.319 0 0 0 0 0 0 0
    20050790
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20052160
    FEBRA- 0 26.264 0 0 0 0 0 0 0 0 0 0 0
    20053770
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20053800
    FEBRA- 0 38.978 0 0 0 0 61.022 0 0 0 0 0 0
    20054270
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20057260
    FEBRA- 0 9.767 0 0 14.061 0 0 0 0 0 0 13.994 0
    20057520
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20059980
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20060920
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20061500
    FEBRA- 0 6.614 0 0 0 6.032 0 0 0 0 0 0 26.259
    20062700
  • TABLE 30
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20063150
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20063540
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20064760
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20066670
    FEBRA- 0 29.836 0 28.216 0 0 0 0 0 0 0 0 0
    20067360
    FEBRA- 0 41.591 0 0 0 0 0 0 0 0 0 0 0
    20067930
    FEBRA- 0 13.327 0 0 0 0 0 6.091 0 6.293 0 0 0
    20068730
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20069420
    FEBRA- 0 58.145 0 0 41.855 0 0 0 0 0 0 0 0
    20070170
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20072000
    FEBRA- 0 25.289 0 0 0 0 0 0 0 0 0 0 0
    20072800
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20074140
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20075510
    FEBRA- 0 100 0 0 0 0 0 0 0 0 0 0 0
    20075660
    HSYRA- 0 8.487 0 0 0 10.321 0 0 0 2.672 0 0 11.233
    20006400
    HSYRA- 0 11.901 0 0 0 0 0 0 0 0 0 0 0
    20015800
    IMR32- 0 2.396 0 4.532 3.45 0 3.751 0 0 0 0 3.433 0
    20002230
    KIDNE- 0 3.312 0 3.132 2.384 3.021 2.593 0 2.338 4.692 0 9.492 0
    20005740
    KIDNE- 0 41.858 0 0 0 0 0 0 0 0 0 0 0
    20053360
    NT2NE- 0 7.99 0 0 0 0 0 0 0 7.546 11.849 0 0
    20002140
    NT2NE- 0 20.031 0 9.472 0 0 0 0 0 0 0 0 0
    20003270
    NT2NE- 0 4.178 0 0 0 0 0 0 5.897 0 0 0 0
    20003840
    NT2NE- 0 12.224 0 11.56 5.866 3.716 12.758 0 0 3.848 0 0 0
    20007870
    NT2NE- 0 29.779 0 0 0 0 0 27.221 0 0 0 0 0
    20047160
    NT2NE- 0 4.057 0 0 0 0 3.811 2.225 1.145 1.533 0 1.163 3.222
    20053710
    NT2RI- 0 12.493 0 0 0 0 0 0 0 0 0 0 0
    20025410
    NT2RI- 0 4.83 0 0 0 6.608 0 0 0 9.123 3.581 0 0
    20051500
    NT2RI- 0 20.676 0 0 29.767 0 0 0 0 0 0 0 0
    20055640
    NT2RI- 0 8.776 0 0 0 16.008 0 8.022 0 0 0 0 0
    20058510
    NT2RI- 0 67.731 0 0 0 0 0 0 0 0 0 0 0
    20061830
    NT2RI- 0 3.043 0 2.877 0 24.975 4.763 8.344 4.295 2.873 0 0 0
    20064120
    NT2RI- 0 4.842 0 0 0 0 0 0 0 0 0 0 0
    20071330
    NT2RI- 0 17.093 0 4.041 6.152 0 13.38 3.906 0 0 12.674 0 0
    20075890
    NT2RI- 0 7.683 0 0 0 7.007 0 0 0 0 0 0 0
    20077230
    NT2RI- 0 19.011 0 0 0 0 0 0 0 0 0 13.621 0
    20094060
    NT2RP- 0 16.014 0 0 0 0 0 0 0 0 23.748 0 0
    70002380
  • TABLE 31
    NT2RP- 0 6.136 0 0 0 0 0 0 0 0 0 8.792 0
    70009060
    NT2RP- 0 15.95 0 0 0 0 0 0 0 0 0 0 0
    70015910
    NT2RP- 0 41.591 0 0 0 0 0 0 0 0 0 0 0
    70094810
    NT2RP- 0 31.425 0 0 0 0 0 0 0 0 0 0 0
    70094980
    PLACE- 0 10.915 0 0 0 0 17.088 0 0 0 0 0 0
    60012810
    PLACE- 0 12.224 0 11.56 5.866 3.716 12.758 0 0 3.848 0 0 0
    60040050
    SKMUS- 0 1.929 0 0 0 0 3.019 1.763 2.722 0 2.86 0 0
    20008630
    SKNMC- 0 4.704 0 0 0 0 0 0 0 0 0 0 0
    20003050
    SKNSH- 0 11.274 0 0 0 0 17.649 0 0 10.647 0 0 0
    20003470
    TESTI- 0 32.494 0 30.73 0 0 0 0 0 0 0 0 0
    20003560
    TESTI- 0 6.873 0 0 0 0 0 0 0 3.245 0 0 0
    20012690
    TESTI- 0 2.471 0 2.337 0 0 0 0 0 0 0 0 0
    20030710
    TESTI- 0 10.101 0 12.736 0 7.677 5.271 1.539 0 6.359 4.993 28.947 0
    20082400
    TRACH- 0 10.327 0 0 0 0 16.167 0 0 0 15.314 0 0
    20009260
    3NB69- 0 0 4.677 0 0 2.97 0 2.977 0 0 0 0 12.929
    10001160
    3NB69- 0 0 7.604 0 0 0 8.289 0 0 0 0 0 0
    20015280
    BRACE- 0 0 23.494 15.469 0 0 0 14.952 0 0 0 0 0
    10000700
    BRACE- 0 0 18.376 24.2 18.42 0 20.03 0 0 0 18.974 0 0
    20019440
    BRAWH- 0 0 49.094 0 0 0 26.756 0 0 0 0 0 0
    20052250
    KIDNE- 0 0 18.126 0 0 0 0 0 0 0 0 0 0
    20045340
    NT2NE- 0 0 10.019 0 0 0 0 0 0 0 0 0 0
    20002590
    NT2NE- 0 0 17.607 11.594 0 0 0 0 0 0 18.18 0 0
    20014030
    NT2RI- 0 0 60.117 0 0 0 0 0 0 0 0 0 0
    20020220
    NT2RI- 0 0 7.839 2.581 7.858 2.489 0 7.484 0 5.155 0 0 10.836
    20026540
    NT2RI- 0 0 27.482 54.286 0 0 0 0 0 0 0 0 0
    20060710
    NT2RI- 0 0 17.159 0 0 0 0 5.46 0 5.641 0 0 0
    20083960
    NT2RI- 0 0 6.466 0 0 4.106 0 0 0 4.252 0 0 0
    20084810
    NT2RP- 0 0 2.798 0 0 0 0 1.781 0 0 0 0 7.735
    70011660
    NT2RP- 0 0 50.561 0 0 0 0 0 0 0 0 0 0
    70021510
    NT2RP- 0 0 23.216 0 0 0 0 0 0 15.265 0 0 0
    70024490
    NT2RP- 0 0 19.395 0 0 0 0 0 0 0 0 0 0
    70026190
    NT2RP- 0 0 15.654 0 0 0 0 0 0 0 0 0 0
    70039600
    NT2RP- 0 0 56.829 0 0 0 0 0 0 0 0 0 0
    70049250
    NT2RP- 0 0 9.68 0 0 0 0 0 0 6.365 0 0 0
    70071770
    NT2RP- 0 0 24.62 0 0 0 0 0 0 16.188 25.42 0 0
    70093940
    NTONG- 0 0 32.847 0 0 0 0 0 0 0 0 0 0
    10002640
  • TABLE 32
    NTONG- 0 0 10.276 0 0 0 0 0 0 6.757 0 0 0
    20002650
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10000420
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10000670
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10000860
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10000910
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10001040
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10001180
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10001190
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    10001220
    OCBBF- 0 0 60.117 0 0 0 0 0 0 0 0 0 0
    20002770
    OCBBF- 0 0 50.533 0 0 0 0 0 0 0 0 0 0
    20002870
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20007190
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20008240
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20009980
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20010750
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20011010
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20011400
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20011760
    OCBBF- 0 0 60.331 0 0 0 0 0 0 39.669 0 0 0
    20014080
    OCBBF- 0 0 50.836 0 0 0 0 0 0 0 0 0 0
    20014940
    OCBBF- 0 0 100 0 0 0 0 0 0 0 0 0 0
    20015270
    OCBBF- 0 0 71.737 0 0 0 0 0 0 0 0 0 0
    20015280
    OCBBF- 0 0 24.693 0 0 0 0 0 0 0 0 0 0
    20015860
    OCBBF- 0 0 64.872 0 0 0 0 0 0 0 0 0 0
    20017060
    PLACE- 0 0 5.034 0 0 0 0 0 0 0 0 0 0
    60043960
    SMINT- 0 0 3.07 0 0 0 0 0 0 0 0 0 0
    20002770
    TESTI- 0 0 51.667 0 0 0 0 0 0 0 0 0 0
    20001790
    TESTI- 0 0 9.849 0 0 0 2.684 0 0 0 0 0 0
    20007840
    TESTI- 0 0 15.137 0 15.173 0 0 0 14.875 0 15.629 0 0
    20009700
    TESTI- 0 0 15.298 0 7.667 4.857 16.674 9.736 15.033 5.029 7.897 0 0
    20027070
    TESTI- 0 0 16.779 0 0 0 9.144 5.339 8.244 5.516 0 0 0
    20053960
    TRACH- 0 0 4.688 0 0 5.954 5.11 0 4.607 0 0 0 0
    20000790
    3NB69- 0 2.443 3.509 2.31 3.517 0 0 0 0 2.307 3.623 0 0
    20010220
    BRACE- 0 29.559 21.228 13.977 21.278 0 0 0 0 13.958 0 0 0
    10001870
    BRAWH- 0 5.654 8.12 5.347 8.139 0 8.851 0 7.98 5.339 0 0 0
    20014840
    BRAWH- 0 9.758 14.015 9.228 0 8.899 15.276 0 0 27.646 0 0 0
    20040950
  • TABLE 33
    FEBRA- 0 41.046 58.954 0 0 0 0 0 0 0 0 0 0
    20011970
    KIDNE- 0 1.07 1.537 1.012 0 1.952 0 0.978 1.51 0 0 3.066 0
    20062480
    NT2RI- 0 18.599 13.356 0 0 2.827 0 0 4.375 2.927 4.597 4.442 0
    20029580
    NT2RI- 0 4.061 5.832 0 5.846 3.704 0 0 0 0 0 0 0
    20035560
    NT2RI- 0 17.204 24.709 16.27 0 15.69 0 0 0 0 0 0 0
    20043980
    NT2RP- 0 6.554 2.353 0 2.359 0 2.565 0 6.938 0 2.43 0 0
    70000760
    NT2RP- 0 6.959 9.994 0 0 0 0 6.361 0 19.715 10.319 0 0
    70042040
    NT2RP- 0 7.736 11.11 0 0 0 0 0 0 14.611 0 0 0
    70069860
    NT2RP- 0 22.251 15.98 0 0 30.441 0 0 15.704 0 0 0 0
    70088550
    OCBBF- 0 25.989 37.328 0 0 0 0 0 36.683 0 0 0 0
    20001260
    TESTI- 0 11.473 8.239 0 0 15.695 0 2.622 0 2.709 0 4.11 0
    10000230
    3NB69- 3.131 0 6.11 4.023 0 0 0 0 6.005 4.018 0 12.192 0
    20017190
    ADRGL- 20.819 0 50.778 0 0 0 0 0 0 0 0 0 0
    10000020
    BRACE- 17.458 0 34.065 11.215 0 0 0 0 16.738 0 0 0 0
    10001660
    BRAWH- 12.03 0 46.948 0 0 0 25.587 0 0 15.435 0 0 0
    10001620
    CTONG- 13.637 0 13.304 0 0 0 0 8.467 0 0 0 0 0
    20028030
    KIDNE- 2.947 0 5.75 0 0 0 0 3.659 5.65 0 0 0 0
    20004030
    KIDNE- 1.54 0 3.005 0 0 0 0 1.913 5.907 3.952 0 0 0
    20060300
    NB9N4- 1.74 0 3.395 0 0 0 0 0 0 0 3.505 0 0
    20000420
    NT2NE- 9.347 0 4.56 0 0 5.79 0 0 4.481 14.99 4.708 0 12.604
    20000560
    NT2NE- 17.081 0 33.329 0 0 0 0 0 0 0 0 0 0
    20004700
    NT2NE- 7.97 0 15.551 0 0 0 0 0 15.282 10.225 0 0 0
    20007630
    NT2RI- 11.856 0 23.135 0 0 29.381 0 0 0 0 0 0 0
    20004120
    NT2RI- 5.338 0 4.166 1.372 0 0 0 0 0 0 0 0 0
    20013420
    NT2RI- 5.159 0 10.066 0 0 0 0 0 0 0 0 0 0
    20033380
    NT2RI- 9.835 0 4.798 0 0 6.093 10.459 6.107 0 0 0 0 0
    20036950
    NT2RI- 2.442 0 2.382 1.569 0 0 0 0 0 4.699 0 0 0
    20053350
    NT2RI- 1.805 0 3.521 0 0 0 0 0 3.461 4.631 0 0 0
    20053680
    NT2RI- 5.854 0 11.422 0 0 0 0 7.269 22.449 0 0 11.395 0
    20078840
    NT2RI- 2.754 0 8.061 1.769 0 0 0 0 0 1.767 2.774 0 0
    20083360
    NT2RI- 4.665 0 6.069 3.996 6.083 1.927 6.615 0 2.982 0 3.133 0 0
    20090650
    NT2RP- 3.638 0 7.098 0 0 0 0 0 0 0 0 0 0
    60001090
    NT2RP- 11.575 0 11.293 0 0 0 0 7.187 0 0 0 0 0
    70004770
    NT2RP- 7.18 0 4.67 0 0 2.966 0 0 0 1.535 2.411 0 0
    70023790
    NT2RP- 20.056 0 19.568 0 0 0 0 0 0 0 0 0 0
    70055200
    NT2RP- 9.507 0 18.55 0 0 0 0 0 0 6.099 0 0 0
    70085570
  • TABLE 34
    NTONG- 3.528 0 6.884 2.266 0 0 3.752 0 0 4.527 3.554 0 0
    10000980
    NTONG- 11.301 0 22.052 0 0 0 0 0 0 0 0 0 0
    20016120
    OCBBF- 12.096 0 11.802 0 0 0 0 0 0 0 0 0 0
    20011240
    OCBBF- 42.373 0 41.34 0 0 0 0 0 0 0 0 0 0
    20012100
    OCBBF- 4.012 0 7.829 0 0 9.943 0 4.983 23.082 10.296 16.167 0 0
    20013070
    OCBBF- 33.884 0 66.116 0 0 0 0 0 0 0 0 0 0
    20014020
    PEBLM- 9.132 0 4.455 0 0 0 4.855 0 0 0 0 0 0
    20003950
    PLACE- 12.74 0 24.859 0 0 0 0 0 0 0 0 0 0
    50001130
    PLACE- 27.281 0 10.646 0 0 0 0 13.551 0 0 0 0 0
    60021510
    PUAEN- 3.444 0 13.439 0 0 0 7.324 4.276 0 0 0 0 0
    10000570
    SKNMC- 2.423 0 1.182 1.557 0 0 2.577 0 0 0.777 0 0 0
    20000970
    TESTI- 1.367 0 2.668 0 0 0 0 0 0 0 2.754 0 0
    20040310
    TRACH- 6.994 0 13.647 0 0 0 0 0 13.411 0 0 0 0
    20004610
    3NB69- 3.772 5.125 0 4.847 0 0 0 0 0 0 0 0 0
    2005450
    BRACE- 3.858 2.62 0 2.478 3.772 2.39 4.102 2.395 7.397 7.424 0 0 0
    10000420
    BRACE- 27.681 18.803 0 8.891 13.535 17.149 0 0 0 0 13.942 0 0
    20076410
    BRACE- 7.698 10.458 0 39.561 0 9.538 32.745 0 0 0 0 0 0
    20078820
    BRAWH- 6.302 25.683 0 0 0 0 26.805 0 12.084 0 0 12.267 0
    20006860
    BRAWH- 9.281 12.609 0 0 0 11.5 19.741 23.052 0 23.817 0 0 0
    20089030
    FCBBF- 20.441 27.77 0 0 0 25.327 0 0 0 0 0 0 0
    10006750
    FCBBF- 42.399 57.601 0 0 0 0 0 0 0 0 0 0 0
    10006860
    FCBBF- 7.341 3.324 0 6.288 0 9.096 0 6.078 0 15.698 9.86 4.764 0
    20015380
    FCBBF- 1.945 5.285 0 0 0 0 0 0 0 0 0 0 0
    50002610
    FEBRA- 45.718 20.704 0 0 0 0 0 0 0 0 0 0 0
    20004520
    FEBRA- 3.428 9.315 0 17.618 0 4.247 0 4.257 0 4.398 0 0 0
    20005360
    FEBRA- 23.228 31.556 0 0 0 0 0 0 0 0 0 45.216 0
    20009010
    FEBRA- 42.399 57.601 0 0 0 0 0 0 0 0 0 0 0
    20014920
    FEBRA- 13.059 17.741 0 0 0 16.18 0 0 0 0 0 0 0
    20015840
    FEBRA- 10.174 13.822 0 0 0 12.605 0 0 0 0 0 0 0
    20021910
    FEBRA- 0.894 2.429 0 2.297 3.497 1.108 0 1.11 0 0 0 1.74 0
    20021940
    FEBRA- 6.453 8.767 0 0 0 0 0 0 0 0 0 0 0
    20043250
    FEBRA- 12.772 34.702 0 0 0 0 0 0 0 0 0 0 0
    20057780
    FEBRA- 22.294 30.288 0 0 0 0 47.417 0 0 0 0 0 0
    20057880
    FEBRA- 59.549 40.451 0 0 0 0 0 0 0 0 0 0 0
    20066270
    FEBRA- 17.81 24.196 0 0 0 0 0 0 0 0 0 0 0
    20074580
    HHDPC- 15.129 10.276 0 0 0 0 0 0 14.505 9.705 0 0 0
    20000550
  • TABLE 35
    HSYRA- 4.24 11.522 0 0 0 5.254 0 0 8.131 5.44 8.543 0 0
    20015740
    HSYRA- 1.233 1.005 0 0 3.859 5.5 0 8.575 3.31 0.949 7.453 5.281 1.33
    20016210
    IMR32- 3.621 4.919 0 0 0 0 0 0 0 0 7.294 0 0
    10002420
    IMR32- 0.382 0.519 0 0 0 0 0 0 0 0.49 0 0.744 0
    20016000
    KIDNE- 7.34 9.972 0 0 0 0 0 0 0 0 0 0 0
    20060140
    MAMGL- 0.301 0.409 0 0 0.59 0.747 0 0.374 0.578 0.387 0 0.587 1.626
    10000320
    NT2NE- 8.923 12.122 0 0 0 0 0 0 0 0 17.976 0 0
    20008090
    NT2NE- 10.711 9.701 0 4.587 13.966 4.424 0 0 0 0 0 0 0
    20014350
    NT2RI- 1.604 1.09 0 0 0 0 1.706 0 0 1.029 0 0 0
    20000640
    NT2RI- 9.692 26.333 0 0 0 0 0 0 0 12.434 0 0 0
    20002940
    NT2RI- 0.148 0.402 0 21.074 0 0.183 0 0.367 0 0 0 0 0
    20015400
    NT2RI- 5.44 14.78 0 20.966 0 6.74 11.569 6.755 0 0 0 0 0
    20033830
    NT2RI- 1.298 1.764 0 0 0 0 2.761 3.224 0 0 2.616 0 0
    20037510
    NT2RI- 2.535 3.444 0 4.885 0 3.141 5.391 4.722 0 3.252 2.553 4.934 0
    20057230
    NT2RI- 2.993 2.033 0 0 2.927 3.709 3.183 0 2.87 3.841 0 2.914 0
    20087910
    NT2RI- 14.023 12.701 0 0 0 5.792 0 0 0 0 0 0 0
    20089420
    NT2RP- 3.934 5.344 0 0 0 0 0 0 0 5.047 7.925 0 0
    70043730
    NT2RP- 4.861 6.604 0 6.246 0 0 0 6.037 0 12.474 0 0 26.221
    70047900
    PLACE- 2.116 2.874 0 5.436 0 5.243 4.5 0 0 2.714 0 4.118 0
    60043120
    PROST- 4.928 6.695 0 6.331 0 6.106 10.481 12.239 0 6.322 0 0 26.581
    20033020
    SYNOV- 3.506 4.763 0 0 0 0 0 0 0 0 7.063 0 0
    10001280
    TESTI- 14.02 4.762 0 0 0 0 0 0 0 0 0 0 0
    20021490
    THYMU- 10.405 14.136 0 0 20.352 0 0 0 0 13.35 20.963 0 0
    20002360
    TRACH- 4.522 1.536 0 0 0 1.401 0 1.404 0 2.901 2.278 2.201 0
    20012890
    3NB69- 2.384 3.239 4.653 0 0 0 10.143 0 0 3.059 0 0 0
    10001290
    BNGH4- 4.385 9.928 2.852 1.878 0 0 0 0 0 1.875 0 0 0
    20004740
    BRACE- 9.437 32.053 27.622 6.063 9.229 0 0 5.86 0 0 0 0 0
    20034490
    BRAWH- 3.286 4.464 6.412 0 6.427 4.071 6.989 4.081 0 4.216 6.62 0 0
    20005220
    FEBRA- 17.948 24.384 35.022 0 0 0 0 0 0 0 0 0 0
    20003770
    FEBRA- 26.742 10.38 29.818 0 0 3.156 0 0 2.442 3.268 0 7.437 0
    20007570
    FEBRA- 19.259 26.164 26.305 2.474 0 2.386 0 0 0 4.942 0 0 0
    20008740
    FEBRA- 13.91 9.449 27.141 0 0 0 0 0 13.336 8.923 0 0 0
    20012450
    FEBRA- 13.91 9.449 27.141 0 0 0 0 0 13.336 8.923 0 0 0
    20012450
    FEBRA- 31.686 7.174 30.913 0 0 0 0 0 0 0 0 0 0
    20017150
    FEBRA- 8.913 24.219 17.392 0 0 0 0 0 0 11.436 0 17.352 0
    20025250
    FEBRA- 19.397 10.541 15.139 0 0 0 0 0 0 0 0 0 0
    20044120
  • TABLE 36
    FEBRA20076220 7.094 1.606 4.614 1.519 0 1.465 0 0 0 1.517 2.382 0 0
    HSYRA20002480 4.385 9.928 2.852 1.878 0 0 0 0 0 1.875 0 0 0
    IMR3220014350 4.337 2.946 4.232 5.572 0 0 4.612 0 0 0 0 0 0
    MESAN20001490 4.119 5.596 8.037 0 0 0 0 0 15.797 0 8.298 0 22.218
    NHNPC20002060 0.878 1.192 1.713 0 0 0 0 1.09 1.683 0 0 0 0
    NT2NE10000180 4.752 6.455 9.271 0 0 17.662 0 5.901 0 12.193 0 0 0
    NT2NE20003920 24.178 24.087 9.435 4.142 0 1.997 0 2.002 0 8.272 3.247 9.413 0
    NT2RI20006690 14.42 6.53 18.758 0 0 0 10.223 0 0 0 0 0 0
    NT2RI20013850 7.701 1.495 2.147 1.413 2.152 0 2.34 0 0 0 2.216 0 0
    NT2RI20014500 8.005 14.501 5.207 3.428 0 16.531 11.351 6.628 5.117 20.542 0 0 0
    NT2RI20025540 5.906 8.024 28.812 0 0 3.659 0 0 0 0 5.95 0 0
    NT2RI20033010 13.235 17.981 51.651 0 0 0 0 0 0 0 0 0 0
    NT2RI20075720 9.059 3.077 22.096 0 0 0 4.817 2.812 0 0 0 4.409 0
    NT2RP60000350 1.407 2.868 9.611 0 0 0.872 0 0 0 2.708 0 0 0
    NT2RP60001230 26.971 10.992 5.263 0 0 3.342 5.736 0 0 3.46 0 0 0
    NT2RP70028750 4.921 7.799 14.402 3.161 3.208 1.016 8.721 0 0 5.261 4.957 3.193 4.424
    NT2RP70029060 3.211 2.181 6.266 2.063 0 9.947 0 1.994 0 4.12 6.47 3.126 0
    NT2RP70032030 18.539 6.297 18.088 0 0 0 14.787 5.756 0 0 0 4.511 0
    NTONG20003340 6.944 9.434 13.549 8.922 13.581 0 0 0 0 0 0 0 0
    OCBBF20000130 3.85 15.691 22.537 0 0 0 0 0 0 0 0 0 0
    OCBBF20002310 8.981 6.1 26.286 0 0 5.564 9.55 11.153 0 11.522 0 0 0
    OCBBF20009040 29.316 13.276 19.068 0 0 0 0 0 0 0 0 0 0
    SKNMC20000650 7.095 7.229 10.382 0 0 0 0 0 0 2.276 3.573 0 9.567
    SMINT20003960 3.445 1.17 3.361 0 0 0 0 0 0 0 0 0 0
    TESTI20026320 6.566 8.92 12.811 0 0 0 0 0 0 0 13.228 0 0
    TESTI20080200 4.326 1.959 7.033 0.926 0 0 9.2 0.895 0 1.85 0 0 3.889
  • TABLE 37
    Clone ID FEHRT HEART
    KIDNE20062480 36.242 0
    NT2RI20033040 40.301 0
    NT2RP60000350 32.381 0
    BGGI120010970 0 9.222
    BRACE10000420 0 23.223
    BRACE10001150 0 1.324
    BRACE20003320 0 31.422
    BRACE20077980 0 15.184
    BRAWH10000370 0 65.363
    BRAWH20000340 0 22.282
    BRAWH20011660 0 6.271
    BRAWH20014840 0 16.703
    FEBRA20008740 0 7.73
    FEBRA20072800 0 74.711
    HEART20000350 0 100
    HEART20000990 0 100
    HEART20003090 0 100
    HEART20004110 0 100
    HEART20004480 0 100
    HEART20004920 0 100
    HEART20005060 0 58.813
    HEART20005200 0 100
    HEART20005680 0 100
    HHDPC20001150 0 23.261
    HLUNG20005010 0 5.241
    HSYRA20014200 0 12.434
    IMR3220013170 0 9.002
    KIDNE20004970 0 26.564
    NT2RI20000640 0 3.219
    NT2RI20006710 0 5.218
    NT2RI20015400 0 0.593
    NT2RI20026540 0 8.062
    NT2RI20037510 0 5.211
    NT2RI20057230 0 20.346
    NT2RI20064120 0 17.978
    NT2RI20071330 0 14.303
    NT2RI20071480 0 24.983
    NT2RI20077540 0 60.787
    NT2RI20084810 0 13.301
    NT2RI20087910 0 6.007
    NT2RP70000760 0 9.681
    NT2RP70024500 0 41.168
    NT2RP70029060 0 6.444
    NTONG10001820 0 13.117
    PLACE60012810 0 32.247
    PLACE60043120 0 8.491
    PROST20000530 0 23.813
    SKMUS10000640 0 27.233
    SKMUS20004580 0 8.731
    SKMUS20015010 0 18.378
    SMINT20002770 0 6.315
    TESTI20033250 0 58.713
    TESTI20074640 0 25.552
    UMVEN20001330 0 6.282
  • TABLE 38
    Clone ID FEKID KIDNE
    3NB6920003300 0 2.071
    3NB6920009120 0 2.884
    BGGI120010970 0 4.336
    BRACE20004210 0 3.583
    BRACE20005250 0 6.242
    BRACE20011170 0 3.303
    BRACE20020910 0 19.111
    BRACE20026850 0 34.356
    BRACE20080970 0 20.33
    BRAWH20000340 0 10.476
    BRAWH20006970 0 3.96
    BRAWH20011660 0 5.897
    FCBBF20001950 0 65.363
    FEBRA20021940 0 1.687
    FEBRA20043250 0 12.177
    HLUNG10000640 0 23.921
    IMR3220007420 0 2.375
    IMR3220014350 0 4.092
    KIDNE10000280 0 100
    KIDNE10000500 0 15.868
    KIDNE10001040 0 100
    KIDNE10001430 0 100
    KIDNE10001450 0 19.052
    KIDNE10001520 0 100
    KIDNE20000410 0 100
    KIDNE20000510 0 100
    KIDNE20000700 0 100
    KIDNE20000850 0 4.788
    KIDNE20001670 0 100
    KIDNE20001920 0 100
    KIDNE20002440 0 37.565
    KIDNE20002450 0 100
    KIDNE20002660 0 7
    KIDNE20003150 0 100
    KIDNE20003300 0 20.536
    KIDNE20003490 0 64.026
    KIDNE20003750 0 100
    KIDNE20004030 0 5.561
    KIDNE20004220 0 35.77
    KIDNE20004970 0 12.49
    KIDNE20005130 0 100
    KIDNE20005170 0 81.524
    KIDNE20005190 0 100
    KIDNE20005740 0 2.3
    KIDNE20031850 0 16.193
    KIDNE20033050 0 3.381
    KIDNE20033350 0 100
    KIDNE20033570 0 53.825
    KIDNE20033730 0 100
    KIDNE20033770 0 100
    KIDNE20037520 0 100
    KIDNE20039410 0 100
    KIDNE20039940 0 43.968
    KIDNE20040340 0 100
    KIDNE20040540 0 49.114
    KIDNE20040840 0 100
    KIDNE20042620 0 100
    KIDNE20042940 0 100
    KIDNE20042950 0 100
    KIDNE20043440 0 100
    KIDNE20045200 0 100
    KIDNE20045340 0 17.53
    KIDNE20045790 0 100
    KIDNE20046810 0 100
    KIDNE20048280 0 100
    KIDNE20048640 0 34.264
    KIDNE20048790 0 100
    KIDNE20049810 0 100
    KIDNE20050420 0 35.626
    KIDNE20052960 0 100
    KIDNE20053360 0 58.142
    KIDNE20054000 0 49.697
    KIDNE20054770 0 100
    KIDNE20056290 0 100
    KIDNE20056760 0 16.262
    KIDNE20059080 0 100
    KIDNE20059370 0 88.03
    KIDNE20060140 0 13.852
    KIDNE20060300 0 2.906
    KIDNE20060530 0 100
    KIDNE20060620 0 100
    KIDNE20061490 0 100
    KIDNE20062480 0 2.972
    KIDNE20062990 0 31.685
    KIDNE20063530 0 26.747
    KIDNE20063760 0 100
    KIDNE20066520 0 70.185
    KIDNE20067600 0 100
    KIDNE20067750 0 8.487
    KIDNE20068800 0 24.137
    KIDNE20070050 0 66.711
    KIDNE20070770 0 100
    KIDNE20071860 0 39.822
    KIDNE20073280 0 4.537
    KIDNE20073520 0 8.83
    KIDNE20073560 0 100
    KIDNE20074220 0 100
    KIDNE20075690 0 100
    KIDNE20078100 0 100
    KIDNE20078110 0 100
    LIVER10000790 0 15.673
    MAMGL10000320 0 1.138
    NB9N410000470 0 3.598
    NT2NE20053710 0 1.127
    NT2RI20006710 0 2.454
    NT2RI20013420 0 2.015
    NT2RI20016570 0 23.435
    NT2RI20018460 0 20.967
    NT2RI20025540 0 5.573
    NT2RI20040590 0 13.676
    NT2RI20065530 0 3.41
    NT2RI20087490 0 1.408
    NT2RI20087910 0 2.824
    NT2RP60000350 0 5.311
    NT2RP60001230 0 5.09
    NT2RP70043730 0 14.846
    NT2RP70069860 0 10.745
    NT2RP70074220 0 3.96
    OCBBF20014940 0 49.164
    PLACE60014430 0 4.704
    PLACE60020840 0 2.658
    PLACE60043120 0 3.992
    PROST10003430 0 25.547
    SKNMC20000970 0 1.143
    SKNSH20001510 0 20.208
    SMINT10000160 0 38.817
    SMINT20003960 0 1.625
    SPLEN20000470 0 66.711
    SPLEN20001340 0 88.909
    SPLEN20003570 0 31.635
    STOMA10000470 0 17.849
    SYNOV10001280 0 6.616
    TESTI10000700 0 25.214
    TESTI20027070 0 14.795
    TESTI20040310 0 2.58
    TRACH10000300 0 11.119
    TRACH20000790 0 4.534
    TRACH20002500 0 35.282
    TRACH20007800 0 5.605
    KIDNE10000080 77.87 22.13
    KIDNE20044110 92.49 7.51
    NT2RI20033040 40.707 0
    NT2RI20037510 60.346 0
    NT2RP70065270 40.543 0
    TRACH20012890 52.552 0
  • TABLE 39
    Clone ID FELNG HLUNG
    BNGH410001980 0 16.113
    BRACE10000420 0 7.831
    BRACE10001150 0 1.339
    BRACE20014770 0 28.126
    BRACE20018550 0 25.65
    BRAWH20006970 0 8.521
    BRAWH20014610 0 7.03
    FEBRA20008810 0 19.713
    FEBRA20015840 0 53.019
    FEBRA20044120 0 15.75
    HHDPC20001490 0 25.611
    HLUNG10000240 0 100
    HLUNG10000300 0 100
    HLUNG10000370 0 100
    HLUNG10000640 0 51.466
    HLUNG10000760 0 12.838
    HLUNG10000990 0 100
    HLUNG10001050 0 100
    HLUNG10001100 0 100
    HLUNG20000680 0 72.532
    HLUNG20001160 0 100
    HLUNG20001250 0 100
    HLUNG20001420 0 79.349
    HLUNG20001760 0 100
    HLUNG20002550 0 100
    HLUNG20003140 0 14.018
    HLUNG20004120 0 42.131
    HLUNG20004800 0 100
    HLUNG20005010 0 5.302
    HSYRA20014200 0 12.578
    KIDNE20002660 0 15.061
    KIDNE20033050 0 3.637
    NT2NE20014350 0 28.99
    NT2RI20016570 0 9.167
    NT2RI20026540 0 8.156
    NT2RI20051500 0 21.652
    NT2RI20064120 0 9.093
    NT2RI20083960 0 17.851
    NT2RI20085260 0 5.474
    NT2RI20087490 0 3.03
    NT2RP70009060 0 18.337
    NT2RP70011660 0 5.822
    NT2RP70029060 0 6.519
    NT2RP70055020 0 10.451
    NT2RP70074220 0 8.521
    NT2RP70076100 0 25.546
    NTONG10002460 0 16.426
    NTONG20008000 0 7.189
    PLACE60043120 0 8.589
    SKMUS20016340 0 15.317
    SKNMC20005930 0 13.727
    SMINT20000180 0 38.989
    SMINT20002390 0 51.283
    SMINT20002770 0 12.776
    SMINT20003960 0 10.489
    STOMA10000470 0 38.402
    STOMA20001880 0 52.43
    SYNOV20013740 0 23.798
    TESTI20036250 0 32.684
    TESTI20080200 0 2.927
    TRACH20004610 0 28.395
    BRACE20004210 86.645 0
    IMR3220007420 57.437 0
  • TABLE 40
    Alteration of the expression level of each clone due to
    TNF-α or LPS stimulation to human monocyte cell line THP-1 and
    alteration of the expression level of each clone due to co-
    culture of gastric cancer cell line MKN45 with Helicobacter
    pylori. ctl, TNF and LPS in the column of THP-1, respectively,
    indicate the relative expression levels in unstimulated THP-1,
    in the cell stimulated with 10 ng/mL TNF-α for 3 hours, and in
    the cell stimulated with 1 μg/mL LPS for 3 hours; ctl and H. pylori
    in the column of MKN45 indicate the relative expression
    levels in MKN45 cultured without Helicobacter pylori and in
    MKN45 co-cultured with Helicobacter pylori
    (at a ratio of MKN45:Helicobacter pylori = 1:100
    cells (colonies) for 3 hours, respectively
    [ATAC-PCR]
    THP-1 MKN45
    Clone name ctl TNF LPS ctl H. pylori
    3NB6920000290 2.0 1.9 0.4 0.1 0.0
    ADRGL10000180 2.2 5.1 2.0 3.3 5.7
    BNGH410001370 0.8 1.4 0.3 0.4 0.5
    BRACE10001590 1.5 2.3 1.6 0.4 0.8
    BRACE10001690 2.3 3.6 2.9 2.2 1.8
    BRACE20010650 2.1 2.2 2.1 2.2 2.1
    BRACE20013400 2.6 0.8 0.2 1.5 1.1
    BRACE20030780 0.3 1.3 0.0 2.2 1.7
    BRACE20034490 2.0 1.6 0.6 2.5 0.3
    BRACE20077640 0.4 1.0 0.1 1.7 0.3
    BRACE20079530 0.6 0.1 0.1 0.0 0.2
    BRACE20083850 0.9 2.5 1.3 1.1 0.0
    BRACE20091880 1.5 0.5 0.1 0.5 0.0
    BRAWH10001620 1.8 1.0 0.3 1.1 3.1
    BRAWH20004430 0.2 1.4 0.2 0.5 0.5
    FCBBF10006180 0.1 3.6 1.3 2.1 0.7
    FEBRA20003780 1.5 3.0 2.8 1.7 1.3
    FEBRA20006800 0.7 2.4 0.9 0.0 1.6
    FEBRA20008810 2.3 1.4 0.9 2.3 1.3
    FEBRA20012940 0.4 1.0 0.2 0.7 0.6
    FEBRA20015840 0.1 3.3 2.6 0.1 0.0
    HCASM10000610 1.8 2.0 2.1 2.3 2.2
    HEART20000350 2.0 3.3 1.8 2.3 0.5
    HEART20004480 0.0 0.3 0.0 3.5 3.0
    HEART20005060 1.2 0.6 0.0 4.8 4.5
    HHDPC20000950 0.4 0.2 0.1 1.4 0.7
    HLUNG10000370 0.0 1.3 0.2 2.6 0.7
    HLUNG20001160 0.6 3.7 1.7 0.1 0.0
    HLUNG20001760 1.4 0.5 0.0 0.3 0.0
    HSYRA20003470 1.1 1.5 0.6 1.1 0.3
    HSYRA20013320 0.1 1.7 0.7 1.4 0.7
    IMR3210001580 0.4 0.0 0.0 0.3 0.2
    IMR3210002660 0.8 0.4 0.2 0.5 0.4
    IMR3220008380 0.4 0.9 0.4 1.1 0.5
    IMR3220008590 2.0 0.3 0.9 2.1 3.4
    KIDNE10001520 0.4 1.2 0.7 3.4 2.2
    KIDNE20000850 0.7 0.7 0.4 1.1 0.5
    KIDNE20003490 0.9 1.7 0.9 0.3 1.9
    KIDNE20005170 0.9 0.7 0.3 6.4 0.2
    KIDNE20033730 1.2 1.6 1.8 0.5 0.5
    KIDNE20040540 0.1 2.5 0.8 0.1 0.2
    KIDNE20050420 0.7 0.5 0.7 0.2 0.3
    KIDNE20061490 0.1 1.2 0.6 0.2 0.1
    KIDNE20062990 0.7 3.5 0.7 0.0 0.0
    LIVER20000330 6.0 7.4 1.1 7.3 0.6
    NT2NE10001630 0.1 2.6 1.4 2.5 2.7
    NT2NE10001850 1.1 0.3 0.1 0.4 1.1
    NT2NE20003920 0.6 3.3 1.6 0.5 0.2
    NT2NE20005500 0.6 2.6 2.2 0.1 0.2
    NT2RI20009740 1.2 1.9 0.9 0.1 0.0
    NT2RI20014500 0.2 3.5 1.7 0.0 0.0
    NT2RI20016570 1.2 3.6 3.1 0.0 0.1
    NT2RI20018660 4.3 0.5 1.3 1.9 1.8
    NT2RI20021520 1.1 1.5 1.1 1.1 0.5
    NT2RI20050870 1.0 0.6 0.3 0.7 0.8
    NT2RI20053350 2.2 1.0 0.9 1.5 0.6
    NT2RI20070480 1.5 0.3 0.0 0.0 0.0
    NT2RI20073030 0.4 0.6 0.4 2.0 0.8
    NT2RI20078270 0.2 2.6 0.5 1.4 0.3
    NT2RI20078790 1.7 2.4 0.7 2.2 1.6
    NT2RI20083360 0.1 0.4 0.2 0.1 0.3
    NT2RP60000080 2.2 2.5 1.5 2.0 1.1
    NT2RP60000390 1.6 2.3 1.2 2.3 0.4
    NT2RP60000590 1.6 2.0 1.3 2.5 1.3
    NTONG10000980 0.9 0.8 0.8 1.9 0.0
    NTONG10002570 0.1 5.4 0.5 0.0 0.0
    PLACE60020160 0.8 1.2 0.6 0.0 0.0
    PLACE60026990 0.5 0.2 0.1 3.2 2.1
    PLACE60047380 1.6 0.7 0.9 1.8 2.2
    PUAEN10003220 0.1 1.9 1.2 0.0 0.1
    SKNMC10000290 0.4 1.2 0.5 0.9 0.2
    SKNMC10001590 1.7 1.9 0.8 1.0 0.4
    SKNMC20000650 1.1 1.1 0.8 0.1 0.1
    STOMA20002570 0.3 3.1 1.5 0.6 0.6
    STOMA20002890 1.8 0.8 0.4 0.1 0.2
    SYNOV20001770 1.7 0.5 0.5 1.7 4.2
    TESTI10000230 2.7 4.6 3.1 2.3 1.7
    TESTI10000550 0.4 0.1 0.3 0.1 2.8
    TESTI20011340 0.3 2.3 2.2 2.2 1.9
    THYMU10005580 1.1 2.1 1.1 1.5 1.1
    TRACH10000630 0.3 0.5 0.2 2.7 2.6
    TRACH20001960 9.4 2.7 1.3 1.0 0.4
    UMVEN10001220 1.9 2.8 1.0 0.8 0.2
    UMVEN20001330 2.2 2.2 0.0 1.0 0.1
    UTERU20004850 1.7 6.3 2.3 0.0 0.3

    Homology Search Result Data
  • Data obtained by the homology search for full-length nucleotide sequences and deduced amino acid sequences.
  • In the result of the search shown below, both units, aa and bp, are used as length units for the sequences to be compared.
  • Each data includes Clone name, Definition in hit data, P value, Length of sequence to be compared, Homology, and Accession number (No.) of hit data. These items are shown in this order and separated by a double-slash mark, //.
  • 3NB6910000180
  • 3NB6910000850
  • 3NB6910001160//STEROIDOGENIC ACUTE REGULATORY PROTEIN PRECURSOR.//9.70E-08//160aa//21%//Q28996
  • 3NB6910001290
  • 3NB6910001730
  • 3NB6920000290
  • 3NB6920002810//PUTATIVE ATP-DEPENDENT RNA HELICASE T26G10.1 IN CHROMOSOME III.//4.70E-154//442aa//64%//P34580
  • 3NB6920003300//YIP1 PROTEIN.//1.80E-35//181aa//41%//P53039
  • 3NB6920005450
  • 3NB6920009120
  • 3NB6920010020//REGULATOR OF G-PROTEIN SIGNALING 3 (RGS3) (RGP3).//1.60E-89//179aa//95%//P49796
  • 3NB6920010220//putative C3HC4-type RING zinc finger protein//3.70E-38//374aa//29%//MC27460
  • 3NB6920013490
  • 3NB6920014330
  • 3NB6920014710//Homo sapiens hepatocellular carcinoma-associated antigen 58 (HCA58) mRNA, complete cds.//5.40E-130//236aa//100%//AF220416
  • 3NB6920015110//CARG-BINDING FACTOR-A (CBF-A).//7.50E-140//290aa//90%//Q99020
  • 3NB6920015280//LIGHT-MEDIATED DEVELOPMENT PROTEIN DET1.//4.6.0E-55//263aa//35%//P48732
  • 3NB6920015570//ZINC FINGER PROTEIN 135.//7.90E-129//365aa//60%//P52742
  • 3NB6920016370
  • 3NB6920017190
  • ADRGL10000020//Homo sapiens Kelch-like 1 protein (KLHL1) mRNA, complete cds.//2.90E-298//546aa//100%//AF252283
  • ADRGL10000180
  • ADRGL10000650//ZINC FINGER PROTEIN 135.//2.20E-76//205aa//64%//P52742
  • ADRGL10001600//CYTOCHROME P450 XXIB (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) (P450-C21B).//2.50E-248//397aa//98%//P08686
  • ADRGL10001650//IMIDAZOLONEPROPIONASE (EC 3.5.2.7) (IMIDAZOLONE-5-PROPIONATE HYDROLASE).//6.10E-67H/418aa//37%//P42084
  • ADRGL10001820
  • ADRGL20000740//RHO-GTPASE-ACTIVATING PROTEIN 6 (RHO-TYPE GTPASE-ACTIVATING PROTEIN RHOGAPX-1).//1.50E-67//327aa//43%//Q43182
  • ADRGL20003230
  • ADRGL20004280
  • ASTRO10000180//DYNEIN INTERMEDIATE CHAIN 3, CILIARY.//1.10E-32//207aa//33%//Q16960
  • ASTRO20000950
  • ASTRO20004170//Homo sapiens sorting nexin 5 (SNX5) mRNA, complete cds.//5.20E-47//98aa//100%//AF121855
  • ASTRO20004800
  • BGGI110002850
  • BGGI120001610//CELL DIVISION CONTROL PROTEIN 1.//3.10E-14//218aa//28%//P40986
  • BGGI120005330//INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE 2 (EC 1.1.1.205) (IMP DEHYDROGENASE 2) (IMPDH-II) (IMPD 2).//1.40E-218//415aa//80%//P12269
  • BGGI120005440//Homo sapiens snurportin1 mRNA, complete cds.//3.50E-199//360aa//99%//AF039029
  • BGGI120006840//Homo sapiens sirtuin type 2 (SIRT2) mRNA, complete cds.//7.60E-197H/371aa//98%//AF083107
  • BGGI120006930//POLYHOMEOTIC-PROXIMAL CHROMATIN PROTEIN.//2.30E-11//100aa//42%//P39769
  • BGGI120010970//Homo sapiens contactin associated protein (Caspr) mRNA, complete cds.//3.50E-103//464aa//36%//U87223
  • BGGI120017140//ZINC FINGER PROTEIN 124 (HZF-16).//1.60E-127//217aa//100%//Q15973
  • BNGH410000030//R. norvegicus trg mRNA.//3.10E-111//361aa//60%//X68101
  • BNGH410000130
  • BNGH410000170
  • BNGH410000290
  • BNGH410000330
  • BNGH410000340//DIPEPTIDYL PEPTIDASE IV (EC 3.4.14.5) (DPP IV) (THYMOCYTE-ACTIVATING MOLECULE) (THAM).//3.20E-36//262aa//38%//P28843
  • BNGH410000390//DYNEIN BETA CHAIN, CILIARY./4.80E-136//331 aa//72%//P23098
  • BNGH410000800//Homo sapiens zinc finger protein dp mRNA, complete cds./2.80E-11//103aa//41%//AF153201
  • BNGH410001040
  • BNGH410001180//Homo sapiens low density lipoprotein receptor related protein-deleted in tumor (LRPDIT) mRNA, complete cds.//Q//752aa//96%//AF176832
  • BNGH410001370//BRUSH BORDER 61.9 KD PROTEIN PRECURSOR.//6.30E-72//555aa//31%//Q05004
  • BNGH410001530
  • BNGH410001770//INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE 1 (EC 1.1.1.205) (IMP DEHYDROGENASE 1) (IMPDH-I) (IMPD 1).//2.10E-270//514aa//99%//P20839
  • BNGH410001900//Rattus norvegicus schlafen-4 (SLFN-4) mRNA, complete cds.//3.80E-81//568aa//35%//AF168795
  • BNGH410001980//TETRACYCLINE RESISTANCE PROTEIN, CLASS E (TETA(E)).//1.20E-15//345aa//26%//Q07282
  • BNGH420004740
  • BNGH420005320//ZINC FINGER PROTEIN 36 (ZINC FINGER PROTEIN KOX18) (FRAGMENT).//6.40E-179//322aa//99%//P17029
  • BRACE10000200
  • BRACE10000420//PROTEIN PHOSPHATASE 2C ABI2 (EC 3.1.3.16) (PP2C).//2.10E-31//202aa//37%//Q04719
  • BRACE10000700
  • BRACE10000730//HYPOTHETICAL 37.2 KDA PROTEIN C12C2.09C IN CHROMOSOME II.//9.60E-05//100aa//34%//Q09749
  • BRACE10000930//TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2).//2.10E-96//197aa//92%//P39429
  • BRACE10001150//NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 2 (BRAIN-SPECIFIC PROTEIN, X-LINKED).//3.60E-17//144aa//36%//P51860
  • BRACE10001590
  • BRACE10001660
  • BRACE10001690
  • BRACE10001870//MICROTUBULE-ASSOCIATED PROTEIN 4.//8.30E-12//49aa//81%//P27816
  • BRACE20000770
  • BRACE20001000
  • BRACE20001410
  • BRACE20002800//MNN4 PROTEIN./8.50E-10//237aa//29%//P36044
  • BRACE20003320
  • BRACE20004210
  • BRACE20005050
  • BRACE20005250//DRR1 PROTEIN (TU3A PROTEIN).//5.20E-74//144aa//100%//Q95990
  • BRACE20005450
  • BRACE20005650
  • BRACE20005770//Homo sapiens PHR1 isoform 4 (PHRET1) mRNA, alternatively spliced, complete cds.//5.80E-48//91aa//100%//AF093249
  • BRACE20006980//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//2.40E-16//279aa//30%//Q01484
  • BRACE20007180//CALCITONIN GENE-RELATED PEPTIDE II PRECURSOR (CGRP-II) (BETA-TYPE CGRP).//2.70E-61//127aa//99%//P10092
  • BRACE20008850//CALDESMON (CDM).//3.50E-08//203aa//29%//P12957
  • BRACE20009880
  • BRACE20010650
  • BRACE20010700
  • BRACE20011170
  • BRACE20011430//Zea mays clone AGPZm1 arabinogalactan protein (agp) mRNA, partial cds.//3.70E-06//176aa//33%//AF134579
  • BRACE20011880
  • BRACE20013400
  • BRACE20013520
  • BRACE20013740
  • BRACE20013750
  • BRACE20014230
  • BRACE20014530//36.4 KDA PROLINE-RICH PROTEIN.//5.50E-10//102aa//34%//Q00451
  • BRACE20014550//HEAT SHOCK FACTOR PROTEIN 1 (HSF 1) (HEAT SHOCK TRANSCRIPTION FACTOR 1) (HSTF 1).//1.00E-118//229aa//99%//Q00613
  • BRACE20014770//HUNTINGTIN ASSOCIATED PROTEIN 1 (HAP1).//1.70E-22//81 aa//39%//P54256
  • BRACE20014920//PROTEIN-TYROSINE PHOSPHATASE-LIKE N PRECURSOR (R-PTP-N) (ISLET CELL AUTOANTIGEN 512) (ICA512).//3.10E-42//110aa//84%//P56722
  • BRACE20015080//PROTEIN-LYSINE 6-OXIDASE PRECURSOR (EC 1.4.3.13) (LYSYL OXIDASE).//1.30E-06//110aa//35%//Q05063
  • BRACE20015430
  • BRACE20016730//Mus musculus mdgl-1 mRNA, complete cds.//3.00E-54//118aa//83%//AF190624
  • BRACE20016920
  • BRACE20017370//P. vivax pva1 gene./2.70E-20//99aa//49%//X92485
  • BRACE20018550//B-CELL LYMPHOMA 3-ENCODED PROTEIN (BCL-3 PROTEIN).//9.20E-16//300aa//30%//P20749
  • BRACE20018590//NOVEL ANTIGEN 2 (NAG-2) (TSPAN-4).//8.30E-28//69aa//91%//Q14817
  • BRACE20018650
  • BRACE20018980
  • BRACE20019440
  • BRACE20020500
  • BRACE20020910//ZINC-FINGER PROTEIN RFP (RET FINGER PROTEIN).//1.10E-31//91aa//49%//Q62158
  • BRACE20021510
  • BRACE20021760
  • BRACE20022020//SERINE/THREONINE-PROTEIN KINASE SNK (EC 2.7.1.-) (SERUM INDUCIBLE KINASE).//1.60E-41//102aa//47%//P53351
  • BRACE20022270
  • BRACE20024090//HOMEOBOX PROTEIN MEIS3 (MEIS1-RELATED PROTEIN 2).//1.50E-108//210aa//89%//P97368
  • BRACE20024310//P53-INDUCED PROTEIN 11.//5.00E-37//111aa//69%//Q14683
  • BRACE20024680//Homo sapiens GalNAc-T9 mRNA for UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, complete cds.//3.00E-153//244aa//99%//AB040672
  • BRACE20024780//NEURALIZED PROTEIN.//1.20E-14//95aa//38%//P29503
  • BRACE20024950
  • BRACE20025900
  • BRACE20026350//SODIUM/NUCLEOSIDE COTRANSPORTER (NA(+)/NUCLEOSIDE COTRANSPORTER).//3.40E-25//53aa//96%//P26430
  • BRACE20026850//Homo sapiens androgen-regulated short-chain dehydrogenase/reductase 1 (ARSDR1) mRNA, complete cds.//6.50E-120//313aa//72%//AF167438
  • BRACE20027360//Homo sapiens mRNA for fructosamine-3-kinase (FN3K gene)//3.00E-80//150aa//91%//AJ404615
  • BRACE20027520
  • BRACE20027550//REGULATOR OF MITOTIC SPINDLE ASSEMBLY 1 (RMSA-1).//1.40E-19//128aa//44%//P49646
  • BRACE20027720//HYDROXYACYLGLUTATHIONE HYDROLASE (EC 3.1.2.6) (GLYOXALASE II) (GLX II).//2.50E-35//133aa//50%//Q16775
  • BRACE20027920//L-RIBULOKINASE (EC 2.7.1.16).//5.20E-40//387aa//29%//P94524
  • BRACE20027960//Rattus norvegicus neurabin mRNA, complete cds.//2.70E-10//48aa//66%//U72994
  • BRACE20028120//Mus musculus GTPase Rab37 (Rab37) mRNA, complete cds.//4.60E-48//129aa//78%//AF233582
  • BRACE20028600
  • BRACE20028610
  • BRACE20028960//Mus musculus mRNA for Ca2+ dependent activator protein for secretion, complete cds.//6.10E-195//473aa//74%//D86214
  • BRACE20030780
  • BRACE20031100//PATCHED PROTEIN HOMOLOG 1-(PTC1) (PTC).//3.00E-23//234aa//25%//Q61115
  • BRACE20032850
  • BRACE20033190
  • BRACE20033980
  • BRACE20034310
  • BRACE20034490
  • BRACE20035160
  • BRACE20035270
  • BRACE20035390
  • BRACE20035940
  • BRACE20071380//PROBABLE CALCIUM-TRANSPORTING ATPASE 3 (EC 3.6.1.38) (ENDOPLASMIC RETICULUM CA2+-ATPASE).//3.50E-65//343aa//39%//P39524
  • BRACE20071530
  • BRACE20071740//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//4.90E-157//380aa//61%//P51523
  • BRACE20071970
  • BRACE20072010
  • BRACE20072320
  • BRACE20072810
  • BRACE20074010//Oryctolagus cuniculus peroxisomal Ca-dependent solute carrier mRNA, complete cds.//2.30E-140//383aa//65%//AF004161
  • BRACE20074470//Mus musculus partial mRNA for mouse fat 1 cadherin (mfat1 gene).//3.90E-131//454aa//57%//AJ250768
  • BRACE20075020
  • BRACE20075270
  • BRACE20075380
  • BRACE20075630
  • BRACE20076210
  • BRACE20076410//Mouse mRNA for seizure-related gene product 6 type 2 precursor, complete cds.//5.10E-173//320aa//94%//D64009
  • BRACE20076460
  • BRACE20076630//Dog nonerythroid beta-spectrin mRNA//1.60E-05//86aa//37%//L02897
  • BRACE20076850//Homo sapiens cell cycle checkpoint protein CHFR mRNA, complete cds.//1.20E-54//104aa//99%//AF170724
  • BRACE20077080
  • BRACE20077270
  • BRACE20077610
  • BRACE20077640
  • BRACE20077670
  • BRACE20077680
  • BRACE20077840//Putative Protein that mediates attachment of autophagosomes to microtubules, by similarity to yeast aut2 [Schizosaccharomyces pombe].//1.00E-08//200aa//26%//CAC00556
  • BRACE20077980
  • BRACE20078680//TOLA PROTEIN.//2.40E-05//140aa//30%//P44678
  • BRACE20078820//actin-depolymerizing protein N-WASP//5.50E-06//116aa//37%//S72273
  • BRACE20079020
  • BRACE20079530
  • BRACE20080970
  • BRACE20081140
  • BRACE20083800
  • BRACE20083850//Rattus norvegicus NRBF-2 mRNA for nuclear receptor binding factor-2, complete cds.//1.30E-135//288aa//90%//AB024930
  • BRACE20084430//PROTEIN DISULFIDE ISOMERASE-RELATED PROTEIN PRECURSOR (EC 5.3.4.1) (PDIR).//8.30E-102//186aa//98%//Q14554
  • BRACE20084800
  • BRACE20084880
  • BRACE20086530
  • BRACE20086550//Homo sapiens mRNA for GABAB receptor, subunit 1b.//8.30E-22//55aa//90%//AJ012186
  • BRACE20087080
  • BRACE20087540
  • BRACE20088570
  • BRACE20089600
  • BRACE20089990
  • BRACE20090140
  • BRACE20091880//Mus musculus mRNA for synaptotagmin V, complete cds.//9.90E-85//166aa//96%//AB026802
  • BRACE20092120
  • BRACE20092740
  • BRACE20092750
  • BRACE20093070//P120 PROTEIN.//1.40E-13//121aa//41%//P30999
  • BRACE20093110
  • BRACE20093610
  • BRACE20094370
  • BRACE20095170
  • BRAWH10000010//Homo sapiens PMEPA1-protein (PMEPA1) mRNA, complete cds.//2.00E-84//250aa//67%//AF224278
  • BRAWH10000020//Homo sapiens putative hepatic transcription factor (WBSCR14) mRNA, complete cds.//1.20E-168//345aa//89%//AF156603
  • BRAWH10000070
  • BRAWH10000370//UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR PRECURSOR (U-PAR) (CD87).//9.40E-08//155aa//29%//Q05588
  • BRAWH10000940//Xenopus laevis mRNA for NfrI, complete cds.//6.10E-257//606aa//77%//D86491
  • BRAWH10001300
  • BRAWH10001620//Rattus norvegicus development-related protein mRNA, complete cds//1.90E-115//339aa//93%//AF045564
  • BRAWH10001640//Homo sapiens KRAB zinc finger protein (RITA) mRNA, complete cds.//5.10E-14//57aa//68%//AF272148
  • BRAWH10001680//Homeotic protein emx2//9.60E-126//252aa//92%//151737
  • BRAWH10001740
  • BRAWH10001800
  • BRAWH20000340//TRP-185 protein//7.20E-28//68aa//97%//S62356
  • BRAWH20000480//Mus musculus kinesin motor protein KIFC2 mRNA, complete cds.//1.50E-120//270aa//85%//U92949
  • BRAWH20000930
  • BRAWH20001090//SARCALUMENIN PRECURSOR.//1.90E-05//363aa//24%//P13666
  • BRAWH20001770//SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (EC 2.1.2.1) (SERINE METHYLASE) (GLYCINE HYDROXYMETHYLTRANSFERASE) (SHMT).//3.20E-41//77aa//100%//P34897
  • BRAWH20002480
  • BRAWH20003230//Proline rich protein//2.00E-29//142aa//52%//CAA48321
  • BRAWH20004430//Human breast cancer, estrogen regulated LIV-1 protein (LIV-1) mRNA, partial cds.//1.00E-46//164aa//46%//U41060
  • BRAWH20004760//Mus musculus mRNA for Eos protein, complete cds.//1.80E-92//180aa//92%//AB017615
  • BRAWH20005030//REGULATOR OF MITOTIC SPINDLE ASSEMBLY 1 (RMSA-1).//6.50E-18//103aa//52%//P49646
  • BRAWH20005220//Homo sapiens hD54+ins2 isoform (hD54) mRNA, complete cds.//1.20E-77//206aa//80%//AF004430
  • BRAWH20005540
  • BRAWH20006330//Homo sapiens mRNA for zinc finger 2 (ZNF2 gene).//1.20E-120//214aa//98%//X60152
  • BRAWH20006510//HYDROXYMETHYLGLUTARYL-COA LYASE (EC 4.1.3.4) (HMG-COA LYASE) (HL) (3-HYDROXY-3-METHYLGLUTARATE-COA LYASE).//1.60E-96//238aa//73%//p35915
  • BRAWH20006860//SERINE/THREONINE-PROTEIN KINASE SGK (EC 2.7.1.-) (SERUM/GLUCOCORTICOID-REGULATED KINASE).//4.20E-223//406aa//99%//Q00141
  • BRAWH20006970
  • BRAWH20008660
  • BRAWH20008920
  • BRAWH20009010//Human (c-myb) gene, complete primary cds, and five complete alternatively spliced cds.//9.70E-28//105aa//59%//U22376
  • BRAWH20009440//Arabidopsis thaliana pollenless3 (178) gene, complete cds: beta-9 tubulin (TUB9) gene, partial cds; and unknown gene.//7.90E-31//271aa//34%//AF060248
  • BRAWH20009840//CYTOCHROME P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (ARACHIDONIC ACID EPOXYGENASE).//1.10E-146//273aa//98%//P51589
  • BRAWH20011030
  • BRAWH20011290//OCCLUDIN.//2.90E-07//174aa//29%//Q61146
  • BRAWH20011410//CUTICLE COLLAGEN 2.//2.30E-05//129aa//35%//P17656
  • BRAWH20011660//BETA-GALACTOSIDASE PRECURSOR (EC 3.2.1.23) (LACTASE) (ACID BETA-GALACTOSIDASE).//1.40E-105//421aa//49%//P16278
  • BRAWH20012030
  • BRAWH20014180//Homo sapiens double-stranded RNA specific adenosine deaminase (ADAR3) mRNA, complete cds.//3.60E-97//179aa//100%//AF034837
  • BRAWH20014380
  • BRAWH20014610
  • BRAWH20014840//POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE (EC 2.4.1.41) (PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE) (UDP-GALNAC:POLYPEPTIDE, N-ACETYLGALACTOSAMINYLTRANSFERASE) (GALNAC-T1).//4.50E-84//511aa//36%//Q07537
  • BRAWH20015030
  • BRAWH20036890//Mus musculus clone mouse1-9 putative protein phosphatase type 2C mRNA, partial cds.//2.70E-59//120aa//98%//AF117832
  • BRAWH20036930
  • BRAWH20038320
  • BRAWH20040950
  • BRAWH20047310
  • BRAWH20052250
  • BRAWH20059980//BONE MORPHOGENETIC PROTEIN 1 PRECURSOR (EC 3.4.24.-) (BMP-1).//8.60E-37//282aa//32%//P98070
  • BRAWH20060440
  • BRAWH20064500//Homo sapiens CAGF9 mRNA, partial cds.//8.00E-25//148aa//51%//U80736
  • BRAWH20064930
  • BRAWH20066220//DYNEIN GAMMA CHAIN, FLAGELLAR OUTER ARM.//3.20E-41//221aa//39%//Q39575
  • BRAWH20069600
  • BRAWH20069890//DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (EC 2.7.7.6) (RPB1) (FRAGMENT).//9.50E-07//188aa//30%//P11414
  • BRAWH20074060
  • BRAWH20076050//LORICRIN.//2.80E-05//160aa//31%//P18165
  • BRAWH20087060
  • BRAWH20089030
  • BRAWH20089560//Protein-tyrosine-phosphatase (EC 3.1.3.48)
  • TD14//0//736aa//90%//T14355
  • BRAWH20092270
  • BRAWH20092610//TLM PROTEIN (TLM ONCOGENE).//3.90E-15//122aa//43%//P17408
  • BRAWH20093600
  • BRAWH20094850
  • CD34C20000510//Human chitotriosidase precursor mRNA, complete cds.//7.80E-247//366aa//98%//U29615
  • CTONG20003030
  • CTONG20005890//CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110 (CHAPSYN-110).//3.10E-18//241aa//31%//15700
  • CTONG20007710
  • CTONG20008270
  • CTONG20011390
  • CTONG20013200//HYPOTHETICAL PROTEIN C2G11.15C IN CHROMOSOME I (FRAGMENT).//1.60E-15//130aa//36%//Q09814
  • CTONG20013660//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//5.00E-11//468aa//23%//P08640
  • CTONG20015330
  • CTONG20018200//Mus musculus NSD1 protein mRNA, complete cds.//Q//1061aa//87%//AF064553
  • CTONG20019110//UBIOUITIN CARBOXYL-TERMINAL HYDROLASE 4 (EC 3.1.2.15) (UBIOUITIN THIOLESTERASE 4) (UBIOUITIN-SPECIFIC PROCESSING PROTEASE 4) (DEUBIOUITINATING ENZYME 4) (UBIQUITOUS NUCLEAR PROTEIN HOMOLOG).//5.40E-19//116aa//39%//Q3107
  • CTONG20019550//Homo sapiens mRNA for actin binding protein ABP620, complete cds.//Q//1175aa//53%//AB029290
  • CTONG20020730
  • CTONG20021430
  • CTONG20024180//Homo sapiens scaffold attachment factor B (SAF-B) mRNA, partial cds.//3.10E-52//366aa//40%//L43631
  • CTONG20024530
  • CTONG20025580//ZINC FINGER PROTEIN 211 (ZINC FINGER PROTEIN C2H2-25).//2.00E-58//223aa//45%//Q13398
  • CTONG20027210//VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13.//7.90E-06//224aa//24%//Q07878
  • CTONG20028030
  • CTONG20028160//Homo sapiens cadherin-like protein VR20 mRNA, partial cds.//9.70E-170//290aa//100%//AF169690
  • CTONG20028200//Mus musculus MGA protein mRNA, complete cds.//Q//1132aa//85%//AF205935
  • CTONG20029650
  • CTONG20037820//GAMMA-AMINOBUTYRIC-ACID RECEPTOR PI SUBUNIT PRECURSOR (GABA(A) RECEPTOR).//4.30E-94//164aa//93%//Q00591
  • CTONG20047160//Rattus norvegicus mRNA for seven transmembrane receptor, complete cds.//1.10E-26//319aa//29%//AB019120
  • CTONG20055530//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN, NONERYTHROID).//1.90E-59//598aa//30%//Q01484
  • CTONG20064490//Drosophila melanogaster 26S proteasome regulatory complex subunit p42A mRNA, complete cds.//1.00E-41//108aa//77%//AF145308
  • D30ST20001840//RNA binding motif protein 9 [Homo sapiens].//1.00E-139//297aa//91%//NP—055124
  • DFNES20002120//Mus musculus tgt mRNA for tRNA-guanine transglycosylase, complete cds.//1.40E-62//140aa//83%//AB034632
  • DFNES20002680//MYOSIN HEAVY CHAIN, STRIATED MUSCLE.//9.00E-26//620aa//24%//P24733
  • DFNES20002920
  • DFNES20003350//CELL SURFACE GLYCOPROTEIN 1 PRECURSOR (OUTER LAYER PROTEIN B) (S-LAYER PROTEIN 1).//5.30E-05//277aa//25%//Q06852
  • DFNES20004320//Homo sapiens ubiquitous TPR-motif protein Y isoform (UTY) gene, partial cds; alternatively spliced.//3.20E-15//85aa//50%//AF265575
  • FCBBF10005980//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//3.20E-151//395aa//57%//P51523
  • FCBBF10006180
  • FCBBF10006750
  • FCBBF10006860
  • FCBBF10006870//Mus musculus Rap2 interacting protein 8 (RPIP8) mRNA, complete cds.//3.10E-113//456aa//53%//U73941
  • FCBBF10006910
  • FCBBF10007320
  • FCBBF10007600
  • FCBBF20000940//MONOCYTIC LEUKEMIA ZINC FINGER PROTEIN (ZINC FINGER PROTEIN 220).//2.70E-05//194aa//28%//Q92794
  • FCBBF20001050
  • FCBBF20001950
  • FCBBF20002320
  • FCBBF20002760//ALPHA SCRUIN.//2.70E-05//214aa//24%//Q25390
  • FCBBF20005760
  • FCBBF20005910//KINESIN LIGHT CHAIN (KLC).//6.40E-10//114aa//39%//P46825
  • FCBBF20006770
  • FCBBF20007330//DIPEPTIDYL PEPTIDASE IV LIKE PROTEIN (DIPEPTIDYL AMINOPEPTIDASE-RELATED PROTEIN) (DIPEPTIDYLPEPTIDASE VI) (DPPX-L/DPPX-S).//1.70E-19//96aa//45%//P46101
  • FCBBF20008080
  • FCBBF20008150//ZYXIN.//7.60E-57//350aa//34%//Q04584
  • FCBBF20009400
  • FCBBF20009510//ZINC FINGER PROTEIN 7 (ZINC FINGER PROTEIN KOX4) (ZINC FINGER PROTEIN HF.16).//2.30E-76//225aa//43%//P17097
  • FCBBF20012110//Leishmania major partial ppg1 gene for proteophosphoglycan.//3.50E-05//256aa//24%//AJ243460
  • FCBBF20012990
  • FCBBF20014800
  • FCBBF20015380//Homo sapiens long chain polyunsaturated fatty acid elongation enzyme (HEL01) mRNA, complete cds.//7.00E-61//319aa//44%//AF231981
  • FCBBF20016720
  • FCBBF20017180
  • FCBBF20017200
  • FCBBF40002820//ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT (BETA-ETF).//3.60E-121//239aa//99%//P38117
  • FCBBF50002610//ZINC FINGER PROTEIN 35 (ZFP-35).//1.40E-137//489aa//50%//P15620
  • FEBRA20000350//Mus musculus MAST205 protein kinase mRNA, complete cds./6.20E-71//190aa//76%//U02313
  • FEBRA20000530//Drosophila melanogaster Diablo (dbo) mRNA, complete cds./6.40E-58//495aa//32%//AF237711
  • FEBRA20001050//KINESIN LIGHT CHAIN (KLC).//4.20E-207//566aa//69%//Q07866
  • FEBRA20001290//PROBABLE TRNA (5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE (EC 2.1.1.61)./14.60E-43//82aa//100%//Q75648
  • FEBRA20003110//Homo sapiens UDP-GlcNAc:a-3-D-mannoside b1,2-N-acetylglucosaminyltransferase 1.2 (MGAT1.2) mRNA, partial cds.//3.80E-92//172aa//98%//AF250859
  • FEBRA20003300
  • FEBRA20003770//Homo sapiens ankyrin repeat-containing protein (CCM1) mRNA, complete cds.//Q//406aa//100%//AF296765
  • FEBRA20003780
  • FEBRA20003910
  • FEBRA20003970//ZINC FINGER PROTEIN 228.//1.60E-118//423aa//52%//Q9UJU3-FEBRA20003990//ZINC FINGER PROTEIN 45 (BRC1744).//4.60E-130//502aa//50%//Q02386
  • FEBRA20004040
  • FEBRA20004150//DRA PROTEIN (DOWN-REGULATED IN ADENOMA).//2.70E-30//150aa//37%//P40879
  • FEBRA20004520
  • FEBRA20004540//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//2.40E-252//425aa//99%//P51522
  • FEBRA20004910
  • FEBRA20005360//Homo sapiens paraneoplastic cancer-testis-brain antigen (MA5) mRNA, complete cds.//5.50E-75//375aa//44%//AF083116
  • FEBRA20006560
  • FEBRA20006800
  • FEBRA20006900
  • FEBRA20007330//45 KDA CALCIUM-BINDING PROTEIN PRECURSOR (STROMAL CELL-DERIVED FACTOR 4) (SDF-4).//3.30E-63//117aa//94%//Q61112
  • FEBRA20007400
  • FEBRA20007570//Homo sapiens BM-009 mRNA, complete cds.//1.30E-59//189aa//66%//AF208851
  • FEBRA20007710
  • FEBRA20007720//Mus musculus strain ICR 90 kDa actin-associated protein palladin mRNA, partial cds.//8.10E-06//144aa//29%//AF205079
  • FEBRA20007870//Homo sapiens putative transcription factor CR53 (CR53) mRNA, partial cds.//6.60E-79//144aa//100%//AF017433
  • FEBRA20008090
  • FEBRA20008560//HYPOTHETICAL 40.9 KDA PROTEIN C08B11.5 IN CHROMOSOME II.//4.30E-05//91aa//31%//Q09442
  • FEBRA20008740
  • FEBRA20008800//SARCALUMENIN PRECURSOR.//2.10E-07//199aa//30%//P13666
  • FEBRA20008810//ACTIN 6 (FRAGMENT).//1.00E-103//369aa//50%//P53459
  • FEBRA20009010
  • FEBRA20009590
  • FEBRA20009720//ZINC FINGER PROTEIN 184 (FRAGMENT).//2.30E-145//514aa//51%//Q99676
  • FEBRA20010930//MONOCARBOXYLATE TRANSPORTER 4 (MCT 4).//9.00E-22//333aa//28%//Q15374
  • FEBRA20011330//26S PROTEASOME REGULATORY SUBUNIT S3 (PROTEASOME SUBUNIT P58).//2.10E-54//113aa//100%//Q43242
  • FEBRA20011460//ZINC FINGER PROTEIN 174 (AW-1).//1.90E-12//60aa//55%//Q15697
  • FEBRA20011970
  • FEBRA20012270
  • FEBRA20012450//NAG14//4.90E-24//399aa//27%//AF196976
  • FEBRA20012940
  • FEBRA20013510
  • FEBRA20014870
  • FEBRA20014920//Mus musculus pecanex 1 mRNA, complete cds.//6.50E-120//313aa//72%//AF096286
  • FEBRA20015840//DELTA-LIKE PROTEIN PRECURSOR (DLK) (PREADIPOCYTE FACTOR 1) (PREF-1) (ADIPOCYTE DIFFERENTIATION INHIBITOR PROTEIN) [CONTAINS: FETAL ANTIGEN 1 (FA1)].//2.90E-64//323aa//39%//Q09163
  • FEBRA20015900
  • FEBRA20015910
  • FEBRA20017060//Human APEG-1 mRNA, complete cds.//7.10E-57//113aa//100%//U57099
  • FEBRA20017150//ZINC-BINDING PROTEIN A33.//4.00E-10//322aa//21%//Q02084
  • FEBRA20017900//Xenopus laevis RRM-containing protein SEB-4 mRNA, complete cds.//1.20E-79//180aa//88%//AF223427
  • FEBRA20019890//HYPOTHETICAL PROTEIN KIAA0167.//1.70E-180//339aa//56%//Q99490
  • FEBRA20020860
  • FEBRA20021910
  • FEBRA20021940
  • FEBRA20024290
  • FEBRA20024420//Homo sapiens partial mRNA for choline dehydrogenase (chdh gene).//1.10E-71//143aa//98%//AJ272267
  • FEBRA20025250//HYPOTHETICAL 73.0 KDA PROTEIN IN CLA4-PUS4 INTERGENIC REGION.//1.40E-09//172aa//29%//P48566
  • FEBRA20027270
  • FEBRA20027830
  • FEBRA20028820
  • FEBRA20028970
  • FEBRA20029080
  • FEBRA20030540//Halocynthia roretzi mRNA for HrPET-1, complete cds.//2.80E-25//155aa//34%//AB029334
  • FEBRA20031550
  • FEBRA20033080
  • FEBRA20034290//RESTIN (CYTOPLASMIC LINKER PROTEIN-170) (CLIP-170).//6.90E-21//87aa//51%//Q42184
  • FEBRA20037070
  • FEBRA20041100//PHOSPHOLIPASE ADRAB-B PRECURSOR (EC 3.1.-.-).//1.10E-119//259aa//83%//Q05017
  • FEBRA20041910
  • FEBRA20042240
  • FEBRA20042370
  • FEBRA20042930
  • FEBRA20043250//Canis familiaris mRNA for C3VS protein.//1.90E-191//589aa//66%//X99145
  • FEBRA20043290//MYOSIN HEAVY CHAIN, CARDIAC MUSCLE ISOFORM (FRAGMENT).//Q//975aa//65%//P29616
  • FEBRA20044120
  • FEBRA20044430
  • FEBRA20044900//R. norvegicus mRNA for CPG2 protein.//8.60E-244//509aa//89%//X95466
  • FEBRA20045920//Homo sapiens mRNA for putative sialoglycoprotease type 2.//5.70E-187//273aa//98%//AJ295148
  • FEBRA20048180//DRR1 PROTEIN (TU3A PROTEIN).//8.80E-56//131aa//87%//Q95990
  • FEBRA20050140//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//4.40E-125//505aa//45%//P51523
  • FEBRA20050790//PROTEIN-TYROSINE PHOSPHATASE STRIATUM-ENRICHED (EC 3.1.3.48) (STEP) (NEURAL-SPECIFIC PROTEIN-TYROSINE PHOSPHATASE) (FRAGMENT).//3.60E-66//149aa//83%//P54829
  • FEBRA20052160//PUTATIVE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE (EC 6.3.5.1) (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]).//6.50E-33//105aa//64%//P38795
  • FEBRA20053770
  • FEBRA20053800//Homo sapiens ubiquitous TPR-motif protein Y isoform (UTY) gene, partial cds; alternatively spliced.//3.20E-08//65aa//49%//AF265575
  • FEBRA20054270
  • FEBRA20057260
  • FEBRA20057520
  • FEBRA20057780//INTEGUMENTARY MUCIN A.1 PRECURSOR (FIM-A.1) (PREPROSPASMOLYSIN)./2.40E-07//120aa//27%//P10667
  • FEBRA20057880//LIM domain only 7 isoform c [Homo sapiens]//1.20E-287//545aa//99%//NP—056667
  • FEBRA20059980
  • FEBRA20060920//SEGMENT POLARITY PROTEIN DISHEVELLED.//6.60E-15//84aa//41%//P51140
  • FEBRA20061500
  • FEBRA20062700//PUTATIVE novel haloacid dehalogenase-like hydrolase family protein similar to (archaea) bacterial proteins) [Homo sapiens].//Q//209aa//100%//CAB43550
  • FEBRA20063150//Homo sapiens topoisomerase II alpha-4 (TOP2A) mRNA, partial cds./8.20E-22//73aa//73%//AF285159
  • FEBRA20063540
  • FEBRA20064760//ZINC FINGER PROTEIN 184 (FRAGMENT).//2.10E-182//547aa//54%//Q99676
  • FEBRA20066270
  • FEBRA20066670
  • FEBRA20067360//HYPOTHETICAL ZINC FINGER PROTEIN KIAA0961.//7.00E-134//472aa//54%//Q9Y2G7
  • FEBRA20067930//PERSEPHIN PRECURSOR (PSP).//7.90E-23//50aa//100%//Q60542
  • FEBRA20068730//Trg protein//1.00E-82//560aa//37%//160486
  • FEBRA20069420//ZINC FINGER PROTEIN 33A (ZINC FINGER PROTEIN KOX31) (KIAA0065) (HA0946) (FRAGMENT).//3.60E-103//264aa//58%//Q06730
  • FEBRA20070170//Homo sapiens TRAF4-associated factor 2 mRNA, partial cds.//1.40E-87//220aa//75%//U83194
  • FEBRA20072000//MYOSIN II HEAVY CHAIN, NON MUSCLE.//3.00E-08//645aa//21%//P08799
  • FEBRA20072800//Human (c-myb) gene, complete primary cds, and five complete alternatively spliced cds.//4.10E-30//97aa//74%//U22376
  • FEBRA20074140
  • FEBRA20074580
  • FEBRA20075510//RAS-RELATED PROTEIN RAB-6.//1.00E-36//88aa//88%//P20340
  • FEBRA20075660//REGULATOR OF MITOTIC SPINDLE ASSEMBLY-1 (RMSA-1).//6.00E-09//84aa//46%//P49646
  • FEBRA20076220
  • HCASM10000210//Plasmodium berghei strain NYU2 merozoite surface protein-1 mRNA, partial cds.//1.50E-08//122aa//28%//AF000413
  • HCASM10000610//HYPOTHETICAL 63.9 KD PROTEIN C1F12.09 IN CHROMOSOME I.//2.80E-14//116aa//31%//Q10351
  • HCASM10001150
  • HCASM20002020
  • HCASM20002140//G1/S-SPECIFIC CYCLIN D3.//8.90E-118//226aa//99%//P30281
  • HCASM20003070
  • HCASM20005340
  • HCASM20005360//Macrophage migration inhibitory factor//2.50E-17//45aa//100%//XP 000858
  • HEART20000350//Transacylases//7.50E-35//267aa//35%//AAB94954
  • HEART20000990
  • HEART20003090//PTB-ASSOCIATED SPLICING FACTOR (PSF).//3.70E-07//143aa//30%//P23246
  • HEART20004110
  • HEART20004480//TROPONIN T, CARDIAC MUSCLE ISOFORMS (TNTC).//2.80E-39//81aa//98%//P45379
  • HEART20004920
  • HEART20005060//ENAMELIN (TUFTELIN).//1.80E-23//215aa//30%//P27628
  • HEART20005200//ANKYRIN 1//5.00E-24//250aa//37%//P16157
  • HEART20005680
  • HHDPC20000550//ADENYLATE KINASE, CHLOROPLAST (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE).//1.60E-14//201aa//24%//P43188
  • HHDPC20000950//Cricetulus griseus layilin mRNA, complete cds.//8.00E-177//373aa//84%//AF093673
  • HHDPC20001150//Mus musculus putative secreted protein ZSIG37 (Zsig37) mRNA, complete cds.//2.00E-91//199aa//83%//AF192499
  • HHDPC20001490//Mus musculus partial mRNA for muscle protein 534 (mg534 gene).//2.10E-80//167aa//88%//AJ250189
  • HHDPC20003150
  • HHDPC20004550//H. sapiens PTPL1 mRNA for protein tyrosine phosphatase.//3.60E-32//371aa//26%//X80289
  • HHDPC20004560
  • HHDPC20004620
  • HLUNG10000240
  • HLUNG10000300
  • HLUNG10000370
  • HLUNG10000640//KARYOGAMY PROTEIN KAR4.//2.20E-27//324aa//27%//P25583
  • HLUNG10000760//Mus musculus mRNA for mSox7, complete cds.//9.90E-186//388aa//87%//AB023419
  • HLUNG10000990//TRICHOHYALIN.//7.00E-06//454aa//21%//P22793
  • HLUNG10001050//MYOTUBULARIN.//4.60E-12//95aa//37%//Q13496
  • HLUNG10001100//PISTIL-SPECIFIC EXTENSIN-LIKE PROTEIN PRECURSOR (PELP).//6.20E-06//117aa//30%//Q03211
  • HLUNG20000680//ZINC FINGER PROTEIN 157.//6.30E-104//443aa//45%//P51786
  • HLUNG20001160//AIG1 PROTEIN.//3.10E-24//271aa//28%//P54120
  • HLUNG20001250
  • HLUNG20001420//Mus musculus putative thymic stromal co-transporter TSCOT mRNA, complete cds.//1.20E-189//478aa//76%//AF148145
  • HLUNG20001760
  • HLUNG20002550//MAST CELL TRYPTASE PRECURSOR (EC 3.4.21.59).//1.10E-43//178aa//47%//P50342
  • HLUNG20003140
  • HLUNG20004120
  • HLUNG20004800
  • HLUNG20005010
  • HSYRA10001190//PROBABLE GYP7 PROTEIN (FRAGMENT).//7.90E-08//157aa//25%//P09379
  • HSYRA10001370//ZINC FINGER PROTEIN 184 (FRAGMENT).//1.70E-149//556aa//50%//Q99676
  • HSYRA10001480
  • HSYRA10001680//HYPOTHETICAL HELICASE C28H8.3 IN CHROMOSOME III./9.30E-61//540aa//32%//Q09475
  • HSYRA10001780
  • HSYRA20001350//CELL POLARITY PROTEIN TEA1.//9.10E-16//211aa//28%//P87061
  • HSYRA20002480
  • HSYRA20002530
  • HSYRA20003470
  • HSYRA20005100//NAM7 PROTEIN (NONSENSE-MEDIATED MRNA DECAY PROTEIN 1) (UP-FRAMESHIFT SUPPRESSOR 1).//6.70E-31//374aa//31%//P30771
  • HSYRA20006050//MYOSIN HEAVY CHAIN, CLONE 203 (FRAGMENT).//3.40E-11//282aa//20%//P39922
  • HSYRA20006290//SKIN SECRETORY PROTEIN XP2 PRECURSOR (APEG PROTEIN).//2.10E-07//168aa//30%//P17437
  • HSYRA20006400//Homo sapiens FRG1 mRNA, complete cds.//1.00E-50//112aa//91%//L76159
  • HSYRA20007600
  • HSYRA20008280
  • HSYRA20011030
  • HSYRA20011530
  • HSYRA20013320//INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 PRECURSOR (IGFBP-3) (IBP-3) (IGF-BINDING PROTEIN 3).//1.60E-130//236aa//99%//P17936
  • HSYRA20014200
  • HSYRA20014760
  • HSYRA20015740//GLUCOSAMINE-6-PHOSPHATE ISOMERASE (EC 5.3.1.10) (GLUCOSAMINE-6-PHOSPHATE DEAMINASE) (GNPDA) (GLCN6P DEAMINASE) (OSCILLIN).//1.70E-133//274aa//87%//Q64422
  • HSYRA20015800
  • HSYRA20016210
  • HSYRA20016310//ZINC FINGER PROTEIN 138 (FRAGMENT).//3.80E-136//237aa//100%//P52744
  • IMR3210000440//Human transmembrane receptor precursor (PTK7) mRNA, complete cds.//1.60E-208//388aa//99%//U40271
  • IMR3210000740
  • IMR3210000750
  • IMR3210001580//Cricetulus griseus layilin mRNA, complete cds.//2.30E-177//373aa//84%//AF093673
  • IMR3210001650
  • IMR3210002420//ZINC FINGER PROTEIN 33A (ZINC FINGER PROTEIN KOX31) (KIMA0065) (HA0946) (FRAGMENT).//3.80E-81//281aa//47%//Q06730
  • IMR3210002660//ZINC/CADMIUM RESISTANCE PROTEIN.//2.50E-10//148aa//25%//P20107
  • IMR3220002230//HINT PROTEIN (PROTEIN KINASE C INHIBITOR 1) (PKCI-1) (17 KD INHIBITOR OF PROTEIN KINASE C).//7.90E-08//97aa//32%//P16436
  • IMR3220003020//Mus. musculus shid mRNA, complete cds.//3.80E-138//337aa//77%//AB018423
  • IMR3220006090
  • IMR3220007420//HYPOTHETICAL ZINC FINGER PROTEIN ZK686.4 IN CHROMOSOME III.//5.50E-50//211aa//48%//P34670
  • IMR3220007750//FOLLISTATIN-RELATED PROTEIN PRECURSOR (TGF-BETA-INDUCIBLE PROTEIN TSC-36).//3.60E-19//229aa//30%//Q62356
  • IMR3220007910//SYNAPSINS IA AND IB (BRAIN PROTEIN 4.1).//5.00E-07//167aa//31%//P17600
  • IMR3220008380//METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL PRECURSOR (EC 2.1.2.9) (MTFMT) (FRAGMENT).//1.10E-147//301aa//90%//Q77480
  • IMR3220008590
  • IMR3220008630//PUTATIVE SPLICING FACTOR, ARGININE/SERINE-RICH 2 (SPLICING FACTOR SC35) (SC-35) (SPLICING COMPONENT, 35 KD).//3.50E-05//98aa//40%//Q09511
  • IMR3220009190//METHIONINE AMINOPEPTIDASE 2 (EC 3.4.11.18) (METAP 2) (PEPTIDASE M 2) (INITIATION FACTOR 2 ASSOCIATED 67 KD GLYCOPROTEIN) (P67).//1.90E-230//418aa//92%//Q08663
  • IMR3220009350
  • IMR3220009530
  • IMR3220009730//DNA43 PROTEIN./6.20E-13//367aa//23%//P32354
  • IMR3220009840
  • IMR3220011850
  • IMR3220012180//Mus musculus pseudouridine synthase 3 (Pus3) mRNA, complete cds.//3.10E-221//483aa//84%//AF266505
  • IMR3220013170//Homo sapiens mRNA for protein phosphatase, complete cds.//9.10E-41//195aa//48%//AB027004
  • IMR3220013320//NEUROFILAMENT TRIPLET M PROTEIN (160 KD NEUROFILAMENT PROTEIN) (NF-M).//5.10E-08//357aa//22%//P08553
  • IMR3220014350//HYPOTHETICAL PROTEIN KIAA0025.//9.70E-60//408aa//37%//Q15011
  • IMR3220014910//Rattus norvegicus tricarboxylate carrier-like protein mRNA, complete cds.//3.90E-43//137aa//57%//AF276997
  • IMR3220016000
  • IMR3220017240
  • KIDNE10000080//Xenopus laevis alpha-1 collagen type II′ mRNA, complete cds.//8.60E-07//244aa//29%//M63596
  • KIDNE10000280
  • KIDNE10000500
  • KIDNE10001040//SYNTAXIN 7.//1.10E-32//249aa//32%//Q15400
  • KIDNE10001430
  • KIDNE10001450
  • KIDNE10001520//Mus musculus yolk sac permease-like molecule 1 (YSPL-1) mRNA, complete cds.1/6.40E-73//159aa//77%//U25739
  • KIDNE20000410//ALANINE-GLYOXYLATE AMINOTRANSFERASE 2 PRECURSOR (EC 2.6.1.44) (AGT 2) (BETA-ALANINE-PYRUVATE AMINOTRANSFERASE) (BETA-ALAMT II).//1.00E-71//167aa//85%//Q64565
  • KIDNE20000510//ZINC FINGER PROTEIN 133.//5.10E-156//503aa//56%//P52736
  • KIDNE20000700
  • KIDNE20000850
  • KIDNE20001670//Mus musculus mRNA for RST, complete cds.//6.80E-123//331aa//72%//AB005451
  • KIDNE20001920
  • KIDNE20002440
  • KIDNE20002450
  • KIDNE20002660
  • KIDNE20003150//AQUAPORIN-7 LIKE (AQUAPORIN ADIPOSE) (AOPAP).//1.80E-44//95aa//92%//Q14520
  • KIDNE20003300//Ikaros-like protein//1.50E-45//160aa//41%//AMC34387
  • KIDNE20003490//Mus musculus putative lysophosphatidic acid acyltransferase mRNA, complete cds.//6.10E-124//291aa//77%//AF015811
  • KIDNE20003750//Mus musculus mRNA for granuphilin-a, complete cds.//1.30E-31//173aa//42%//AB025258
  • KIDNE20004030
  • KIDNE20004220//Homo sapiens topoisomerase II alpha-4 (TOP2A) mRNA, partial cds.//3.70E-21//76aa//72%//AF285159
  • KIDNE20004970//TRICHOHYALIN.//1.50E-06//244aa//27%//P37709
  • KIDNE20005130//ALANINE-GLYOXYLATE AMINOTRANSFERASE 2 PRECURSOR (EC 2.6.1.44) (AGT 2) (BETA-ALANINE-PYRUVATE AMINOTRANSFERASE) (BETA-ALAAT II).//1.30E-153//337aa//84%//Q64565
  • KIDNE20005170//HYPOTHETICAL 49.1 KD PROTEIN C11D3.06 IN CHROMOSOME I.//2.20E-30//247aa//31%//Q10085
  • KIDNE20005190//TONB PROTEIN.//2.60E-08//93aa//34%//Q06432
  • KIDNE20005740//Staphylococcus epidermidis putative cell-surface adhesin SdrF (sdrF) gene, complete cds.//3.10E-34//372aa//28%//AF245041
  • KIDNE20031850//Ras association (RalGDS/AF-6) domain family 2; KIMA0168 gene product [Homo sapiens]//4.00E-66//250aa//59%//NP—055552
  • KIDNE20033050//PUTATIVE AMIDASE AF1954 (EC 3.5.1.4).//8.30E-34//242aa//32%//Q28325
  • KIDNE20033350
  • KIDNE20033570
  • KIDNE20033730//Homo sapiens Asef mRNA for APC-stimulated guanine nucleotide exchange factor, complete cds.//3.90E-184//572aa//61%//AB042199
  • KIDNE20033770
  • KIDNE20037520
  • KIDNE20039410//HYPOTHETICAL 37.2 KDA PROTEIN C12C2.09C IN CHROMOSOME II.//3.20E-19//209aa//22%//Q09749
  • KIDNE20039940//ZINC FINGER PROTEIN 191.//1.40E-82//308aa//56%//Q14754
  • KIDNE20040340
  • KIDNE20040540
  • KIDNE20040840//Morone saxatilis myosin heavy chain FM3A (FM3A) mRNA, complete cds.//Q//1135aa//64%//AF003249
  • KIDNE20042620
  • KIDNE20042940
  • KIDNE20042950//Human mRNA for prepro-alpha2(1) collagen (COL1A2).//1.40E-05//96aa//37%//Y00724
  • KIDNE20043440//Vacuolar protein sorting-associated protein—fission yeast//9.00E-34//400aa//33%//T39106
  • KIDNE20044110//Homo sapiens vacuolar proton pump 116 kDa accessory subunit (ATP6N1B) mRNA, complete cds, alternatively spliced.//3.80E-278//322aa//91%//AF245517
  • KIDNE20045200
  • KIDNE20045340
  • KIDNE20045790
  • KIDNE20046810//Mus musculus peroxisomal long chain acyl-CoA thioesterase Ib (Pte1b) gene, exon 3 and complete cds.//2.80E-87//219aa//73%//AF180801
  • KIDNE20048280//Mus musculus orphan transporter isoform A12 (Xtrp2) mRNA, alternatively spliced, complete cds.//2.70E-265//600aa//76%//AF075262
  • KIDNE20048640
  • KIDNE20048790
  • KIDNE20049810
  • KIDNE20050420//LYSOSOMAL TRAFFICKING REGULATOR (BEIGE HOMOLOG).//5.00E-97//283aa//50%//Q99698
  • KIDNE20052960//ACTIN, CYTOPLASMIC 1 (BETA-ACTIN).//2.70E-16//68aa//67%//P12714
  • KIDNE20053360//Homo sapiens antigen NY-C0-31 (NY-C0-31) mRNA, partial cds.//6.40E-12//66aa//54%//AF039697
  • KIDNE20054000
  • KIDNE20054770//Drosophila melanogaster minidiscs (mnd) mRNA, complete cds.//4.80E-69//474aa//34%//AF139834
  • KIDNE20056290//Bos taurus mRNA for mitochondrial aralkyl acylCoA:amino acid N-acyltransferase.//6.40E-58//297aa//40%//AJ223301
  • KIDNE20056760//NEURONAL PROTEIN.//6.50E-44//118aa//75%//P41737
  • KIDNE20059080//Plakophilin 4 [Homo sapiens].//Q//669aa//98%//NP—003619
  • KIDNE20059370
  • KIDNE20060140//Rattus norvegicus selective LIM binding factor mRNA, complete cds.//1.30E-255//339aa//94%//AF226993
  • KIDNE20060300//Gallus gallus syndesmos mRNA, complete cds.//3.10E-42//149aa//62%//AF095446
  • KIDNE20060530//Mus musculus mRNA for acetylglucosaminyltransferase-like protein.//3.70E-252//633aa//69%//AJ006278
  • KIDNE20060620
  • KIDNE20061490//Xenopus laevis RING finger protein mRNA, complete cds.//6.80E-19//36aa//40%//U63817
  • KIDNE20062480
  • KIDNE20062990//BOB1 PROTEIN (BEM1-BINDING PROTEIN).//8.00E-06//332aa//22%//P38041
  • KIDNE20063530
  • KIDNE20063760//GAMMA-GLUTAMYLTRANSPEPTIDASE 1 PRECURSOR (EC 2.3.2.2) (GAMMA-GLUTAMYLTRANSFERASE 1).//7.70E-20//62aa//83%//P19440
  • KIDNE20066520
  • KIDNE20067600//PROSTAGLANDIN F2-ALPHA RECEPTOR REGULATORY PROTEIN PRECURSOR (PROSTAGLANDIN F2-ALPHA RECEPTOR ASSOCIATED PROTEIN).//1.90E-23//293aa//26%//Q62786
  • KIDNE20067750//Homo sapiens PTOV1 (PTOV1) gene, complete cds.//7.60E-62//283aa//53%//AF238381
  • KIDNE20068800//ACTIN INTERACTING PROTEIN 2.//4.60E-33//143aa//51%//P46681
  • KIDNE20070050
  • KIDNE20070770
  • KIDNE20071860
  • KIDNE20073280//L. mexicana Imsap2 gene for secreted acid phosphatase 2 (SAP2).//3.30E-05//365aa//23%//Z46970
  • KIDNE20073520//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//3.00E-15//536aa//23%//P08640
  • KIDNE20073560
  • KIDNE20074220
  • KIDNE20075690//CLAUDIN-10 (OSP LIKE PROTEIN).//6.60E-90//224aa//77%//P78369
  • KIDNE20078100//DEOXYURIDINE 5′-TRIPHOSPHATE NUCLEOTIDOHYDROLASE (EC 3.6.1.23) (DUTPASE) (DUTP PYROPHOSPHATASE).//7.80E-16//100aa//44%//Q41033
  • KIDNE20078110//ZINC FINGER PROTEIN 202.//3.10E-67//427aa//40%//Q95125
  • LIVER10000580
  • LIVER10000670//UROCANATE HYDRATASE (EC 4.2.1.49) (UROCANASE) (IMIDAZOLONEPROPIONATE HYDROLASE).//1.50E-87//380aa//35%//P53385
  • LIVER10000790//Rattus norvegicus fertility related protein WMP1 mRNA, complete cds.//2.70E-82//254aa//65%//AF094609
  • LIVER10000990
  • LIVER10001040//Rattus norvegicus kidney-specific protein (KS) mRNA, complete cds.//6.00E-149//333aa//79%//AF062389
  • LIVER10001110
  • LIVER10001750
  • LIVER10002300//NADH-UBIOUINONE OXIDOREDUCTASE 51 KD SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) (COMPLEX I-51 KD) (CI-51 KD).//1.80E-99//183aa//100%//P49821
  • LIVER10002780
  • LIVER10003030
  • LIVER10004330//Homo sapiens mRNA for neuropathy target esterase.//1.30E-256//710aa//68%//AJ004832
  • LIVER10005420//Mus musculus TAGL-alpha mRNA, complete cds.//1.20E-204//373aa//76%//AF149837
  • LIVER20000330//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 1, ENDOTHELIAL (B12 PROTEIN).//1.80E-10//193aa//27%//Q13829
  • LIVER20000370//ALPHA-1B-GLYCOPROTEIN.//5.00E-159//304aa//96%//P04217
  • LIVER20004160
  • LIVER20004460
  • LIVER20005150
  • MAMGL10000320
  • MAMGL10000350
  • MAMGL10000560
  • MAMGL10001780//PUTATIVE PRE-MRNA SPLICING FACTOR RNA HELICASE (DEAH BOX PROTEIN 15) (ATP-DEPENDENT RNA HELICASE #46).//2.10E-80//166aa//92%//Q43143
  • MAMGL10001820//SEGMENT POLARITY PROTEIN DISHEVELLED.//1.10E-12//84aa//41%//P51140
  • MAMGL10001840
  • MESAN10000350//MAJOR SURFACE-LABELED TROPHOZOITE ANTIGEN PRECURSOR.//2.10E-06//179aa//29%//P21849
  • MESAN10001010//Rat trg gene product//6.00E-94//600aa//36%//160486
  • MESAN10001470
  • MESAN10001800//BB1=malignant cell expression-enhanced gene/tumor progression-enhanced gene [human, UM-UC-9 bladder carcinoma cell line, mRNA, 1897 nt].//1.60E-162//348aa//87%//S82470
  • MESAN20000920//Guanylate kinase-interacting protein 1 Maguin-1, membrane-associated//7.60E-155//477aa//62%//T18293
  • MESAN20001490//HYPOTHETICAL 175.8 KD PROTEIN IN GND1-IKI1 INTERGENIC REGION.//6.70E-163//346aa//58%//P38873
  • MESAN20002670
  • MESAN20002910//HISTIDYL-TRNA SYNTHETASE (EC 6.1.1.21) (HISTIDINE-TRNA LIGASE) (HISRS).//3.60E-98//202aa//96%//P12081
  • MESAN20003370
  • MESAN20005010//Homo sapiens DNA cytosine methyltransferase 3 alpha (DNMT3A) mRNA, complete cds.//6.60E-09//95aa//33%//AF067972
  • NB9N410000470//Homo sapiens NY-REN-45 antigen mRNA, complete cds.//9.70E-247//250aa//99%//AF155110
  • NB9N410001210
  • NB9N410001350//RAS-RELATED PROTEIN RAB-LA (YPT1-RELATED PROTEIN).//1.00E-70//109aa//100%//P11476
  • NB9N410001460
  • NB9N420000420
  • NB9N420001040//Mus musculus Shc binding protein (mPAL) mRNA, complete cds.//4.40E-286//672aa//77%//AF017152
  • NB9N420004950//PROBABLE NUCLEAR ANTIGEN.//5.00E-05//246aa//31%//P33485
  • NESOP10000870//HOMEOBOX PROTEIN SAX-1 (CHOX-3) (FRAGMENT).//1.70E-05//88aa//38%//P19601
  • NHNPC10000840//Homo sapiens poly-U binding splicing factor PUF60 (PUF60) mRNA, partial cds.//6.80E-196//380aa//99%//AF190744
  • NHNPC10001010
  • NHNPC10001240//PAIRED MESODERM HOMEOBOX PROTEIN 2A (PAIRED-LIKE HOMEOBOX 2A) (PHOX2A HOMEODOMAIN PROTEIN)./8.00E-05//109aa//28%//Q62066
  • NHNPC20002060//Bovine viral diarrhea virus type 2 strain BVDV2-SD1630c polyprotein gene, partial cds./8.70E-77//153aa//92%//AF268178
  • NHNPC20002120//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//2.20E-130//357aa//63%//P51522
  • NT2NE10000040
  • NT2NE10000140//Schizosaccharomyces pombe caffeine-induced death protein 1 (cid1)mRNA, complete cds.//1.00E-31//350aa//29%//AF105076
  • NT2NE10000180//SUPPRESSOR PROTEIN SRP40./2.50E-06//219aa//23%//P32583
  • NT2NE10000230
  • NT2NE10000630//Gallus gallus Dach2 protein (Dach2) mRNA, complete cds.//1.90E-147//194aa//78%//AF198349
  • NT2NE10000730//RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT (EC 2.5.1.-) (RAB GERANYL-GERANYLTRANSFERASE ALPHA SUBUNIT) (RAB GG TRANSFERASE) (RAB GGTASE).//3.30E-07//142aa//33%//Q92696
  • NT2NE10000830//POSSIBLE GUSTATORY RECEPTOR CLONE PTEO1 (FRAGMENT).//2.40E-56//182aa//62%//P35894
  • NT2NE10001200
  • NT2NE10001630
  • NT2NE10001850//UDP-N-ACETYLGLUCOSAMINE-PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT (EC 2.4.1.-) (O-GLCNAC TRANSFERASE P110 SUBUNIT).//6.80E-30//395aa//28%//P56558
  • NT2NE20000380
  • NT2NE20000560
  • NT2NE20000640
  • NT2NE20001740
  • NT2NE20002140//DUAL SPECIFICITY PROTEIN PHOSPHATASE 8 (EC 3.1.3.48) (EC 3.1.3.16) (NEURONAL TYROSINE THREONINE PHOSPHATASE 1).//1.00E-131//487aa//51%//Q09112
  • NT2NE20002590//OOCYTE ZINC FINGER PROTEIN XLCOF6.1 (FRAGMENT).//6.30E-30//77aa//53%//P18750
  • NT2NE20002990//69 KD ISLET CELL AUTOANTIGEN (ICA69) (ISLET CELL AUTOANTIGEN 1).//3.30E-113//335aa//57%//Q05084
  • NT2NE20003270//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//7.00E-21//739aa//22%//P08640
  • NT2NE20003690//PROPIONYL-COA CARBOXYLASE ALPHA CHAIN PRECURSOR (EC 6.4.1.3) (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE).//1.80E-26//68aa//86%//P05165
  • NT2NE20003840//MICRONUCLEAR LINKER HISTONE POLYPROTEIN (MIC LH) [CONTAINS: LINKER HISTONE PROTEINS ALPHA, BETA, DELTA AND GAMMA].//7.80E-10//366aa//22%//P40631
  • NT2NE20003920
  • NT2NE20004550//sdk (sidekick) protein//4.90E-11//177aa//31%//T13924
  • NT2NE20004700
  • NT2NE20005170//Homo sapiens ciliary-dynein heavy chain 9 (DNAH9) mRNA, complete cds.//1.20E-103//226aa//90%//AF257737
  • NT2NE20005360//40S RIBOSOMAL PROTEIN SA (P40) (34/67 KD LAMININ RECEPTOR) (COLON CARCINOMA LAMININ-BINDING PROTEIN) (NEM/1CHD4)./1.50E-47//91aa//98%//P08865
  • NT2NE20005500
  • NT2NE20005860//Rattus norvegicus endo-alpha-D-mannosidase (Enman) mRNA, complete cds.//1.70E-85//207aa//69%//AF023657
  • NT2NE20006360
  • NT2NE20006580//Homo sapiens mRNA for RET finger protein-like 2//1.10E-152//288aa//98%//AJ010231
  • NT2NE20007060
  • NT2NE20007630
  • NT2NE20007870
  • NT2NE20008020
  • NT2NE20008090//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//1.90E-207//511aa//71%//Q03923
  • NT2NE20009800
  • NT2NE20011560
  • NT2NE20012470
  • NT2NE20013240
  • NT2NE203370//Homo sapiens estrogen-responsive B box protein (EBBP) mRNA, complete cds.//4.30E-208//394aa//97%//AF096870
  • NT2NE20013640
  • NT2NE20013720//Homo sapiens mRNA for putative ribulose-5-phosphate-epimerase, partial cds.//7.90E-58//116aa//98%//AJ224326
  • NT2NE20014030
  • NT2NE20014280
  • NT2NE20014350
  • NT2NE20015300
  • NT2NE20016230
  • NT2NE20016260//Homo sapiens G-protein coupled receptor RE2 mRNA, complete cds.//2.00E-148//270aa//100%//AF091890
  • NT2NE20016340//NADH-UBIQUINONE OXIDOREDUCTASE 9 KD SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) (COMPLEX I-9 KD) (CI-9 KD).//5.50E-26//86aa//68%//P56181
  • NT2NE20016480
  • NT2NE20016660//PUTATIVE ATP-DEPENDENT RNA HELICASE YDLO31W.//3.90E-15//176aa//30%//Q12389
  • NT2NE20016970//MSF1 PROTEIN.//3.00E-23//169aa//34%//P35200
  • NT2NE20034080//Rattus norvegicus neurestin alpha mRNA, complete cds.//3.70E-258//449aa//99%//AF086607
  • NT2NE20035690//Homo sapiens phosphoinositol 3-phosphate-binding protein-2 (PEPP2) mRNA, complete cds.//1.60E-180//227aa//98%//AF302150
  • NT2NE20044900
  • NT2NE20047160//Homo sapiens AD-017 protein mRNA, complete cds.//2.70E-91//357aa//47%//AF157318
  • NT2NE20053710
  • NT2NE20054410//SPLICEOSOME ASSOCIATED PROTEIN 49 (SAP 49) (SF3B53).//4.50E-06//121aa//33%//Q15427
  • NT2NE20055170//Homo sapiens torsinA (DYT1) mRNA, complete cds.//9.50E-159//232aa//89%//AF007871
  • NT2NE20057200//Mus musculus Ubc6p homolog mRNA, complete cds.//3.80E-108//222aa//91%//U93242
  • NT2RI10000160
  • NT2RI10000270
  • NT2RI10000480//Homo sapiens MKP-1 like protein tyrosine phosphatase mRNA, complete cds.//8.30E-49//179aa//50%//AF038844
  • NT2RI10001640
  • NT2RI20000640
  • NT2RI20002700
  • NT2RI20002820//NUCLEOLAR AUTOANTIGEN N055.//5.00E-243//437aa//100%//Q92791
  • NT2RI20002940
  • NT2RI20003410//ZINC FINGER PROTEIN 43 (ZINC PROTEIN HTF6).//9.30E-226//578aa//70%//P28160
  • NT2RI20004120//CREB-BINDING PROTEIN.//4.40E-05//170aa//30%//Q92793
  • NT2RI20004210//ZINC FINGER PROTEIN 75.//1.10E-96//225aa//76%//P51815
  • NT2RI20005970
  • NT2RI20006690//TRICHOHYALIN./7.10E-17//222aa//32%//P37709
  • NT2RI20006710
  • NT2RI20006850//HISTONE H1.2 (H1 VAR. 1) (H1C).//3.30E-05//54aa//25%//P15864
  • NT2RI20007380
  • NT2RI20008650
  • NT2RI20009740
  • NT2RI20010100//FATTY ACYL-COA HYDROLASE PRECURSOR, MEDIUM CHAIN (EC 3.1.2.14) (THIOESTERASE B).1//1.10E-114//425aa//46%//Q04791
  • NT2RI20010830//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//2.30E-174//554aa//51%//P51523
  • NT2RI20010910//SPLICING FACTOR, ARGININE/SERINE-RICH 4 (PRE-MRNA SPLICING FACTOR SRP75).//3.40E-22//195aa//36%//Q08170
  • NT2RI20012350
  • NT2RI20012440
  • NT2RI20013420//Mus musculus cyclin ania-6b mRNA, partial cds.//2.70E-73//163aa//91%//AF211859
  • NT2RI20013850//Homo sapiens P381P (P381P) mRNA, complete cds.//7.70E-101//213aa//95%//AF093250
  • NT2RI20014090//DYSTROPHIN.//3.60E-15//546aa//20%//P11531
  • NT2RI20014100
  • NT2RI20014490//Mus musculus retinoic acid-responsive protein (Stra6) mRNA, complete cds.//1.30E-263//672aa//73%//AF062476
  • NT2RI20014500//TRICHOHYALIN.//4.80E-19//610aa//23%//Q07283
  • NT2RI20015190//Homo sapiens misato mRNA, partial cds.//7.60E-149//271aa//100%//AF272833
  • NT2RI20015400//Alcohol dehydrogenase/ribitol dehydrogenase//4.30E-107//469aa//44%//AAB93456
  • NT2RI20015950//Zea mays clone AGPZm1 arabinogalactan protein (agp) mRNA, partial cds.//5.60E-05//180aa//32%//AF134579
  • NT2RI20016210//Probable transposase—human transposon MER37//3.50E-19//156aa//35%//S72481
  • NT2RI20016570
  • NT2RI20017260
  • NT2RI20018460//basic domain/leucine zipper transcription factor//3.00E-52//203aa//59%//AAA65688
  • NT2RI20018660//Mus musculus erythroid membrane-associated protein ERMAP (Ermap) mRNA, complete cds.//9.20E-187//385aa//72%//AF153906
  • NT2RI20020220//VARIANT-SURFACE-GLYCOPROTEIN PHOSPHOLIPASE C (EC 3.1.4.47) (VSG LIPASE) (GLYCOSYLPHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C) (GPI-PLC).//5.60E-21//271aa//27%//Q15886
  • NT2RI20020410//SALIVARY PROLINE-RICH PROTEIN PO (ALLELE K) [CONTAINS: PEPTIDE P-D] (FRAGMENT).//1.20E-05//127aa//32%//P10162
  • NT2RI20021520
  • NT2RI20022430
  • NT2RI20022520
  • NT2RI20022700//X123 protein//7.20E-80//165aa//97%//168673
  • NT2RI20025170//Homo sapiens PAR3 (PAR3) mRNA, complete cds.//1.30E-113//373aa//45%//AF252293
  • NT2RI20025300//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//1.40E-14//628aa//21%//P08640
  • NT2RI20025410//ZINC FINGER PROTEIN 135.//3.90E-72//301aa//42%//P52742
  • NT2RI20025540//NUCLEAR AUTOANTIGENIC SPERM PROTEIN (NASP).//1.1E-312//604aa//98%//P49321
  • NT2RI20025850//PUTATIVE 90.2 KD ZINC FINGER PROTEIN IN CCA1-ADK2 INTERGENIC REGION.//1.40E-73//246aa//42%//P39956
  • NT2RI20026540
  • NT2RI20028020
  • NT2RI20028520
  • NT2RI20029260//ARP2/3 COMPLEX 16 KDA SUBUNIT (P16-ARC).//1.00E-52//154aa//68%//Q15511
  • NT2RI20029580//Homo sapiens mRNA for copine VI protein.//1.00E-207//425aa//73%//AJ133798
  • NT2RI20029700
  • NT2RI20030110//Mus musculus clone:2-65 mRNA, complete cds.//2.30E-28//124aa//50%//AB030198
  • NT2RI20030190
  • NT2RI20030510
  • NT2RI20030670
  • NT2RI20031540//DXS6673E PROTEIN.//2.80E-05//240aa//22%//Q14202
  • NT2RI20032050//Homo sapiens transportin2 mRNA, complete cds.//Q//663aa//98%//AF019039
  • NT2RI20032220//INTRACELLULAR PROTEIN TRANSPORT PROTEIN US01.//4.90E-16//582aa//23%//P25386
  • NT2RI20033010//Homo sapiens UDP-GlcNAc:a-3-D-mannoside b1,2-N-acetylglucosaminyltransferase 1.2 (MGAT1.2) mRNA, partial cds.//1.40E-293//579aa//93%//AF250859
  • NT2RI20033040
  • NT2RI20033380
  • NT2RI20033440//PRESYNAPTIC PROTEIN SAP97 (SYNAPSE-ASSOCIATED PROTEIN 97) (DISCS, LARGE HOMOLOG 1).//2.20E-08//128aa//36%//Q12959
  • NT2RI20033830//Homo sapiens SGC32445 protein (SGC32445) mRNA, complete cds.//1.80E-67//134aa//100%//AF251041
  • NT2RI20035560
  • NT2RI20036780//SERINE PROTEASE PC6 PRECURSOR (EC 3.4.21.-) (SUBTILISIN/KEXIN-LIKE PROTEASE PC5) (CONVERTASE PC5).//Q//633aa//97%//P41413
  • NT2RI20036950//TRICHOHYALIN.//1.70E-13//313aa//25%//P37709
  • NT2RI20037510//FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (EC 3.2.2.23) (FAPY-DNA GLYCOSYLASE).//1.20E-05//238aa//28%//P74290
  • NT2RI20040590
  • NT2RI20041900//REGULATOR OF MITOTIC SPINDLE ASSEMBLY 1 (RMSA-1).//3.20E-13//108aa//44%//P49646
  • NT2RI20042840
  • NT2RI20043040//Homo sapiens NY-REN-2 antigen mRNA, complete cds.//2.80E-188//539aa//65%//AF155095
  • NT2RI20043980
  • NT2RI20044420
  • NT2RI20046060
  • NT2RI20047830
  • NT2RI20048400
  • NT2RI20049160
  • NT2RI20049840
  • NT2RI20049850
  • NT2RI20050610
  • NT2RI20050870//Homo sapiens putative anion transporter 1 mRNA, complete cds.//8.10E-262//533aa//96%//AF279265
  • NT2RI20051500//Mus musculus ST6GalNAc V mRNA for GD1 alpha synthase, complete cds.//2.40E-168//336aa//90%//AB030836
  • NT2RI20053350//DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19.//2.00E-23//234aa//32%//P40469
  • NT2RI20053680//Homo sapiens NY-REN-36 antigen mRNA, partial cds.//5.80E-62//124aa//100%//AF155106
  • NT2RI20055640//Mus musculus mRNA for ganglioside-induced differentiation associated protein 1.//2.50E-100//319aa//58%//Y17850
  • NT2RI20056280
  • NT2RI20056470//KERATIN, TYPE II CYTOSKELETAL 4 (CYTOKERATIN 4) (K4) (CK4).//2.40E-278//534aa//99%//P19013
  • NT2RI20057230//SPLICING FACTOR, ARGININE/SERINE-RICH 4 (PRE-MRNA SPLICING FACTOR SRP75).//3.00E-28//241aa//36%//Q08170
  • NT2RI20058110//CELL DIVISION CONTROL PROTEIN 25.//3.30E-18//419aa//25%//P04821
  • NT2RI20058510//PLECTIN.//3.50E-07//551aa//21%//P30427
  • NT2RI20060710//ZINC FINGER PROTEIN ZIC4 (ZINC FINGER PROTEIN OF THE CEREBELLUM 4).//2.10E-153//312aa//86%//Q61467
  • NT2RI20060720//HYPOTHETICAL PROTEIN KIAA0179.//0//692aa//99%//Q14684
  • NT2RI20061270
  • NT2RI20061830//Proline-rich protein M14 precursor//1.50E-17//170aa//37%//A28996
  • NT2RI20062100//Mus musculus shd mRNA, complete cds.//1.00E-137//337aa//77%//AB018423
  • NT2RI20063450
  • NT2RI20064120//Rattus norvegicus mRNA for CDCrel-1A, complete cds.//6.70E-148//280aa//98%//AB027143
  • NT2RI20064870
  • NT2RI20065060//Drosophila melanogaster rudimentary gene, intron 3; anon-15AB gene, complete cds.//1.40E-07//212aa//23%//AF172941
  • NT2RI20065530
  • NT2RI20066670
  • NT2RI20066790
  • NT2RI20066820//Human WW domain binding protein-1 mRNA, complete cds.//5.70E-46//181aa//46%//U79457
  • NT2RI20067030//Homo sapiens nolp mRNA, complete cds.//1.80E-85//406aa//51%//AB017800
  • NT2RI20067350//Neofelis nebulosa strain nnex zinc finger protein Zfx (Zfx) gene, partial cds.//2.10E-23//245aa//27%//AF252979
  • NT2RI20067880
  • NT2RI20068250
  • NT2RI20068550//Homo sapiens RNA helicase (RIG-I) mRNA, complete cds.//1.20E-52//340aa//34%//AF038963
  • NT2RI20070480//Mus musculus DXImx48e protein (DXImx48e) mRNA, complete cds.//3.40E-169//467aa//72%//AF229644
  • NT2RI20070840
  • NT2RI20070960//PROTO-ONCOGENE DBL PRECURSOR [CONTAINS: MCF2].//4.10E-30//431aa//27%//P10911
  • NT2RI20071160
  • NT2RI20071330//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7)./2.80E-240//647aa//64%//Q05481
  • NT2RI20071480
  • NT2RI20072140
  • NT2RI20072540//Arabidopsis thaliana ZCF61 mRNA, complete cds.//2.20E-12//113aa//35%//AB028228
  • NT2RI20073030
  • NT2RI20073840//Homo sapiens mixed lineage kinase mRNA, complete cds.//2.30E-179//362aa//93%//AF238255
  • NT2RI20073860
  • NT2RI20074390//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//2.30E-97//489aa//41%//P51523
  • NT2RI20074690//Homo sapiens NY-REN-58 antigen mRNA, complete cds.//4.00E-221//438aa//99%//AF155115
  • NT2RI20074980//Homo sapiens carboxypeptidase Z precursor, mRNA, complete cds.//3.10E-189//357aa//96%//U83411
  • NT2RI20075070
  • NT2RI20075720
  • NT2RI20075890
  • NT2RI20077230//Homo sapiens BRI3 mRNA, complete cds.//1.80E-114//182aa//99%//AF272043
  • NT2RI20077290
  • NT2RI20077510
  • NT2RI20077540//INTESTINAL MEMBRANE A4 PROTEIN (DIFFERENTIATION-DEPENDENT PROTEIN A4) (PROTEOLIPID PROTEIN 2).//2.30E-12//111aa//33%//Q04941
  • NT2RI20078270
  • NT2RI20078790//HOMEOBOX PROTEIN HOX-A4 (CHOX-1.4).//7.80E-08//83aa//43%//P17277
  • NT2RI20078840//ARS BINDING PROTEIN 1.//1.50E-17/313aa//27%//P49777
  • NT2RI20078910//DMR-N9 PROTEIN.//1.40E-122//398aa//59%//Q08274
  • NT2RI20080500//BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR (HSPG) (PERLECAN) (PLC).//5.90E-43//528aa//28%//P98160
  • NT2RI20081880//Mus musculus Mporc-b mRNA for porcupine-B, complete cds.//4.40E-64//125aa//97%//AB036746
  • NT2RI20082210//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B) (SPR1B) (SPR1 B).//4.70E-12//110aa//37%//Q62267
  • NT2RI20083360
  • NT2RI20083960//Homo sapiens mRNA for SH3 binding protein, complete cds.//3.60E-31//159aa//44%//AB005047
  • NT2RI20084810//1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ALPHA (EC 2.3.1.51) (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE-ALPHA) (LPAMT-ALPHA).//4.70E-60//114aa//99%//Q99943
  • NT2RI20085260
  • NT2RI20085980//MILK FAT GLOBULE-EGF FACTOR 8 PRECURSOR (MFG-E8) (MGP57/53) (PAS-6/PAS-7 GLYCOPROTEIN) (MFGM) (SPERM SURFACE PROTEIN SP47) (BP47) (COMPONENTS 15/16).//5.40E-31//174aa//41%//Q95114
  • NT2RI20086560
  • NT2RI20087140//Homo sapiens PR-domain zinc finger protein 5 (PRDM5) mRNA, complete cds.//6.10E-51//101aa//99%//AF272897
  • NT2RI20087490//SPLICEOSOME ASSOCIATED PROTEIN 49 (SAP 49) (SF3B53).//2.00E-08//156aa//37%//Q15427
  • NT2RI20087910//PROBABLE URACIL PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.9) (UMP PYROPHOSPHORYLASE) (UPRTASE).//1.80E-42//159aa//54%//Q13867
  • NT2RI20088010
  • NT2RI20088120//AXONEME-ASSOCIATED PROTEIN MST101(2).//4.00E-05//185aa//24%//Q08696
  • NT2RI20089420//NEURAL CELL ADHESION MOLECULE L1 PRECURSOR (N-CAM L1).//3.00E-07//104aa//31%//Q05695
  • NT2RI20090650//ZINC FINGER PROTEIN 26 (ZFP-26) (MKR3 PROTEIN) (FRAGMENT).//2.10E-30//194aa//37%//P10076
  • NT2RI20090660//PLECTIN.//7.20E-14//450aa//24%//P30427
  • NT2RI20090830
  • NT2RI20091440
  • NT2RI20092150//ZINC FINGER PROTEIN 165.//3.10E-46//179aa//56%//P49910
  • NT2RI20092890//CARBOXYPEPTIDASE N 83 KD CHAIN (CARBOXYPEPTIDASE N REGULATORY SUBUNIT) (FRAGMENT).//3.70E-29//293aa//31%//P22792
  • NT2RI20094060//Homo sapiens rec mRNA, complete cds.//1.40E-112//293aa//62%//AB023584
  • NT2RP60000080//Homo sapiens Pig11 (PIG11) mRNA, complete cds.//6.60E-38//117aa//71%//AF010315
  • NT2RP60000170
  • NT2RP60000320
  • NT2RP60000350//Homo sapiens mRNA for SH3 binding protein, complete cds.//1.30E-54//253aa//45%//AB005047
  • NT2RP60000390
  • NT2RP60000590
  • NT2RP60000720//Pinus taeda clone PtaAGP6 putative arabinogalactan protein mRNA, complete cds.//1.50E-05//165aa//29%//AF101785
  • NT2RP60000866//Homo sapiens mRNA for NICE-5 protein.//6.30E-192//883 bp//99%//AJ243666
  • NT2RP60001000//ZINC FINGER PROTEIN 41 (FRAGMENT).//7.10E-128//366aa//59%//P51814
  • NT2RP60001090//RING CANAL PROTEIN (KELCH PROTEIN).//6.40E-0.79//553aa//33%//Q04652
  • NT2RP60001230//KINESIN LIGHT CHAIN (KLC).//1.10E-206//566aa//69%//Q07866
  • NT2RP60001270//ZINC FINGER PROTEIN ZIC4 (ZINC FINGER PROTEIN OF THE CEREBELLUM 4).//3.70E-131//264aa//87%//Q61467
  • NT2RP70000410
  • NT2RP70000690//MUCIN 1 PRECURSOR (POLYMORPHIC EPITHELIAL MUCIN) (PEM), (PEMT) (EPISIALIN) (TUMOR-ASSOCIATED MUCIN) (CARCINOMA-ASSOCIATED MUCIN) (TUMOR-ASSOCIATED EPITHELIAL MEMBRANE. ANTIGEN) (EMA) (H23AG) (PEANUT-REACTIVE URINARY MUCIN) (PUM) (BREAST CARCINOMA-ASSOCIATED ANTIGEN DF3).//2.00E-26//911aa//25%//P15941
  • NT2RP70000760//TRANSLATION INITIATION FACTOR EIF-2B EPSILON SUBUNIT (EIF-2B GDP-GTP EXCHANGE FACTOR).//1.70E-23//66aa//81%//P47823
  • NT2RP70002380//Adiantum capillus-veneris AcExt1 mRNA for Extensin, complete cds.//2.00E-05//93aa//37%//AB008227
  • NT2RP70002590//HYPOTHETICAL 32.0 KDA PROTEIN IN NNF1-STE24 INTERGENIC REGION.//2.20E-12//251aa//28%//P47153
  • NT2RP70002710//Mus musculus zinc finger protein 276 C2H2 type (Zfp276) mRNA, complete cds.//1.80E-101//253aa//77%//AF178935
  • NT2RP70003640
  • NT2RP70003910
  • NT2RP70004250//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B (CELLULAR MYOSIN HEAVY CHAIN, TYPE B) (NMMHC-B).//4.30E-08//244aa//24%//P35580
  • NT2RP70004770//UDP-N-ACETYLGLUCOSAMINE-PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT (EC 2.4.1.-) (0-GLCNAC TRANSFERASE P110 SUBUNIT).//1.00E-22//213aa//32%//P56558
  • NT2RP70005790
  • NT2RP70006240//Phosphatidylinositol-4-phosphate 5-kinase homolog T3K9.2//1.90E-16//204aa//30%//T02098
  • NT2RP70008120//HOMEOBOX PROTEIN HOX-B9 (HOX-2.5).//2.40E-53//117aa//87%//P20615
  • NT2RP70009060//Medicago truncatula mRNA for 85p protein (85p gene).//5.10E-07//229aa//23%//AJ249679
  • NT2RP70010800//Mus musculus mRNA for MILI (Miwi like), complete cds.//2.40E-280//614aa//83%//AB032605
  • NT2RP70011660//PROBABLE CATION-TRANSPORTING ATPASE C10C6.6 IN CHROMOSOME IV (EC 3.6.1.-).//1/H1165aa//53%//P90747
  • NT2RP70012310
  • NT2RP70013060//U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA (U1 SNRNP 70 KDA).//1.50E-30//241aa//32%//P09406
  • NT2RP70013350
  • NT2RP70015910//bK57G9.1 (novel Kringle and CUB domain protein) [Homo sapiens].//1.00E-140//247aa//95%//CAB62952
  • NT2RP70018560//Mus musculus polyhomeotic (mPh2) mRNA, complete cds.//5.00E-232//465aa//91%//U81491
  • NT2RP70021510
  • NT2RP70022430//Tax1-binding protein TRX—human.//6.00E-71//180aa//93%//S68091
  • NT2RP70023760//M PROTEIN, SEROTYPE 2.1 PRECURSOR.//2.20E-13//331 aa//25%//P50468
  • NT2RP70023790//110 KDA ANTIGEN (PK110) (FRAGMENT).//7.00E-07//162aa//23%//P13813
  • NT2RP70024490
  • NT2RP70024500//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//4.80E-66//312aa//38%//P51523
  • NT2RP70025540
  • NT2RP70026190//Mus musculus ubiquitin-protein ligase E3-alpha (Ubr1) mRNA, complete cds.//6.20E-305//597aa//93%//AF061555
  • NT2RP70028290//Scm-related gene containing four mbt domains [Mus musculus].//6.00E-59//500aa//31%//NP—062333
  • NT2RP70028410
  • NT2RP70028750//RESTIN (CYTOPLASMIC LINKER PROTEIN-170 ALPHA-2) (CLIP-170) (REED-STERNBERG INTERMEDIATE FILAMENT ASSOCIATED PROTEIN).//2.60E-11//87aa//44%//P30622
  • NT2RP70029060//HEAT SHOCK PROTEIN HSP 90ALPHA (HSP 86).//Q//731aa//99%//P07900
  • NT2RP70029820//Homo sapiens GROS1-L protein mRNA, complete cds.//2.40E-177//680aa//51%//AF097432
  • NT2RP70030500
  • NT2RP70030550
  • NT2RP70030910
  • NT2RP70032030//ZINC FINGER PROTEIN 184 (FRAGMENT).//3.50E-139//366aa//55%//Q99676
  • NT2RP70033040//YceA protein homolog ybfQ—Bacillus subtilis.//1.00E-35//300aa//33%//C69750
  • NT2RP70036290//MHC CLASS II TRANSACTIVATOR CIITA.//4.80E-09//116aa//31%//P33076
  • NT2RP70036320//Microfilarial sheath protein//5.00E-06//92aa//35%//S46966
  • NT2RP70036470
  • NT2RP70036800//RING CANAL PROTEIN (KELCH PROTEIN).//4.50E-107//652aa//38%//Q04652
  • NT2RP70039600
  • NT2RP70040800//CELL SURFACE GLYCOPROTEIN 1 PRECURSOR (OUTER LAYER PROTEIN B) (S-LAYER PROTEIN 1).//5.60E-20//307aa//28%//Q06852
  • NT2RP70042040//ZINC FINGER PROTEIN MLZ-4 (ZINC FINGER PROTEIN 46).//9.20E-61//254aa//46%//Q03309
  • NT2RP70042330//HYPOTHETICAL PROTEIN MJ0941.//8.80E-06//133aa//24%//Q57711
  • NT2RP70042600//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B (CELLULAR MYOSIN HEAVY CHAIN, TYPE B) (NMMHC-B).//4.50E-21//715aa//21%//P35580
  • NT2RP70043730
  • NT2RP70043960//Mus musculus mRNA for Fish protein.//Q//866aa//88%//AJ007012
  • NT2RP70045410//Mus musculus MGA protein mRNA, complete cds.//2.70E-265//1040aa//57%//AF205935
  • NT2RP70046560//PEREGRIN (BR140 PROTEIN).//1.30E-48//304aa//36%//P55201
  • NT2RP70046870//VEGETATIBLE INCOMPATIBILITY PROTEIN HET-E-1.//9.70E-07//395aa//24%//Q00808
  • NT2RP70047510
  • NT2RP70047660
  • NT2RP70047900
  • NT2RP70049150//Mus musculus mRNA for UBE-1c1, UBE-1c2, UBE-1c3, complete cds.//6.60E-56//209aa//52%//AB030505
  • NT2RP70049250//VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP).//1.90E-08//118aa//33%//P50552
  • NT2RP70049750
  • NT2RP70052050//Human transformation-related protein mRNA, 3′ end.//2.20E-12//74aa//52%//L24521
  • NT2RP70052190
  • NT2RP70054680
  • NT2RP70054930
  • NT2RP70055020//Homo sapiens mRNA for paraplegin-like protein.//3.00E-29//68aa//94%//Y18314
  • NT2RP70055130//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//7.00E-130//461aa//46%//P51523
  • NT2RP70055200//INTEGUMENTARY MUCIN A.1 PRECURSOR (FIM-A.1) (PREPROSPASMOLYSIN).//2.40E-07//120aa//27%//P10667
  • NT2RP70061620//ZINC FINGER PROTEIN MFG-3./3.60E-16//266aa//27%//P16374
  • NT2RP70061880//GTPASE-ACTIVATING PROTEIN.//1.70E-08//265aa//21%//P33277
  • NT2RP70062960//EXCISION REPAIR PROTEIN ERCC-6 (COCKAYNE SYNDROME PROTEIN CSB).//5.80E-67//185aa//46%//Q03468
  • NT2RP70063040//Homo sapiens MLL septin-like fusion protein (MSF) mRNA, complete cds.//1.00E-187//348aa//99%//AF123052
  • NT2RP70063740
  • NT2RP70064080//Drosophila melanogaster F protein (olf186) mRNA, complete cds./2.50E-54//203aa//56%//AF188634
  • NT2RP70064900//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//1.20E-149//580aa//40%//P51523
  • NT2RP70065270//LIM-ONLY PROTEIN 6 (TRIPLE LIM DOMAIN PROTEIN 6).//2.40E-136//341aa//61%//Q43900
  • NT2RP70066210
  • NT2RP70067010
  • NT2RP70069800
  • NT2RP70069860//ZINC FINGER PROTEIN 184 (FRAGMENT).//4.40E-141//566aa//46%//Q99676
  • NT2RP70071140
  • NT2RP70071540
  • NT2RP70071770//Homo sapiens multiple membrane spanning receptor TRC8 (TRC8) mRNA, complete cds.//8.50E-61//599aa//29%//AF064801
  • NT2RP70072210//Rattus norvegicus schlafen-4 (SLFN-4) mRNA, complete cds.//1.10E-19//244aa//32%//AF168795
  • NT2RP70072520//Human serine/threonine kinase mRNA, partial cds.//1.20E-79//154aa//100%//U79240
  • NT2RP70073590
  • NT2RP70073810//Sulfonylurea receptor 2A//4.50E-70//135aa//100%//NP—064694
  • NT2RP70074060
  • NT2RP70074220//SYNAPSIN I (BRAIN PROTEIN 4.1).//2.20E-05//116aa//34%//P17600
  • NT2RP70075040
  • NT2RP70075370//52 KDA RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (RO(SS-A)).//1.20E-97//482aa//42%//P19474
  • NT2RP70076100//Homo sapiens mRNA for putative phospholipase, complete cds.//7.10E-189//424aa//53%//AB019435
  • NT2RP70076170
  • NT2RP70076430//PUTATIVE IMPORTIN BETA-4 SUBUNIT (KARYOPHERIN BETA-4 SUBUNIT).//1.70E-42//692aa//26%//Q60100
  • NT2RP70079250//Homo sapiens contactin associated protein (Caspr) mRNA, complete cds.//2.30E-218//963aa//42%//U87223
  • NT2RP70079300
  • NT2RP70079750//Homo sapiens BAC526N18 neurexin III gene, partial cds.//5.00E-177//334aa//100%/AF123462
  • NT2RP70081330
  • NT2RP70081370//ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1 (ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE 1).//1.10E-56//364aa//36%//P41233
  • NT2RP70081420
  • NT2RP70081440//DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 (EC 2.7.1.-) (MAP KINASE KINASE 4) (JNK ACTIVATING KINASE 1) (C-JUN N-TERMINAL KINASE KINASE 1) (JNKK) (SAPK/ERK KINASE 1) (SEK1).//7.20E-77//162aa//91%//P45985
  • NT2RP70081670//85.1 KDA PROTEIN IN GREB-FEOA INTERGENIC REGION.//3.10E-108//568aa//38%//P46837
  • NT2RP70083150//ENVELOPE GLYCOPROTEIN GP340 (MEMBRANE ANTIGEN) (MA) [CONTAINS: GLYCOPROTEIN GP220].//3.60E-09//431aa//23%//P03200
  • NT2RP70084060//Probable hexosyltransferase (EC 2.4.1.-) SC2G5.06//4.90E-07//127aa//32%//T34839
  • NT2RP70084410//Polybromo 1 protein—chicken//Q//985aa//88%//S60678
  • NT2RP70084870//TRICHOHYALIN.//9.20E-16//452aa//21%//P37709
  • NT2RP70085500//Mus musculus rig-1 protein mRNA, complete cds.//Q//976aa//86%//AF060570
  • NT2RP70085570//DNA BINDING PROTEIN URE-B1 (EC 6.3.2.-).//3.40E-23//282aa//27%//P51593
  • NT2RP70086230
  • NT2RP70087200//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//1.20E-164//689aa//42%//P51523
  • NT2RP70088550//Rattus norvegicus membrane-associated guanylate kinase-interacting protein 2 Maguin-2 mRNA, complete cds.//7.90E-267//434aa//98%//AF102854
  • NT2RP70090120//CHLORIDE CHANNEL PROTEIN 7 (CLC-7) (FRAGMENT).//Q//734aa//99%//P51798
  • NT2RP70090190//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN HPF1).//3.60E-146//395aa//61%//P51522
  • NT2RP70091490//GLUCOSE TRANSPORTER TYPE 2, LIVER.//3.30E-17//109aa//37%//P14246
  • NT2RP70091680
  • NT2RP70092150
  • NT2RP70092360//BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR (HSPG) (PERLECAN) (PLC).//4.50E-91//1310aa//26%//Q05793
  • NT2RP70092590
  • NT2RP70093220//CHLORIDE CHANNEL PROTEIN 5 (CLC-5).//Q//746aa//99%//P51795
  • NT2RP70093630
  • NT2RP70093700//PUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC 2.7.1.-).//9.90E-11//241aa//21%//P49695
  • NT2RP70093730
  • NT2RP70093940//Exocyst complex protein sec5//0//924aa//93%//T09220
  • NT2RP70093970
  • NT2RP70094290
  • NT2RP70094660
  • NT2RP70094810//Drosophila melanogaster Dispatched (dispatched) mRNA, complete cds.//1.00E-105//579aa//38%//AF200691
  • NT2RP70094980//FIBULIN-1, ISOFORM A PRECURSOR.//6.50E-30//211aa//38%//P23142
  • NT2RP70095020
  • NT2RP70095070
  • NTONG10000330
  • NTONG10000520//Rattus norvegicus mRNA for Kelch related protein 1 (krp1 gene).//2.00E-118//439aa//49%//AJ293948
  • NTONG10000980
  • NTONG10001230//Mus msuculus mRNA, partial cds, clone CLFEST42.//6.10E-07//217aa//25%//D82816
  • NTONG10001300//Gallus gallus kinectin mRNA, complete cds.//1.30E-15//534aa//22%//U15617
  • NTONG10001820//Mus musculus mammalian inositol hexakisphosphate kinase 1 (Ip6k1) mRNA, complete cds.//5.20E-77//294aa//53%//AF177144
  • NTONG10002140//SARCALUMENIN PRECURSOR.//3.50E-204//376aa//97%//P13666
  • NTONG10002460//CYCLIN-DEPENDENT KINASE INHIBITOR 1C (CYCLIN-DEPENDENT KINASE INHIBITOR P57) (P57KIP2).//1.10E-16//156aa//40%//P49918
  • NTONG10002570
  • NTONG10002640//HYPOTHETICAL 71.1 KD PROTEIN IN DSK2-CAT8 INTERGENIC REGION.//6.90E-98//603aa//39%//Q03262
  • NTONG20002650//Probable transmembrane protein of fission yeast//8.50E-63//539aa//28%//T39483
  • NTONG20003340//ZINC FINGER PROTEIN 90 (ZFP-90) (ZINC FINGER PROTEIN NK10).//3.10E-108//225aa//83%//Q61967
  • NTONG20003630//CREB-BINDING PROTEIN.//3.00E-05//160aa//31%//Q92793
  • NTONG20004920
  • NTONG20005830
  • NTONG20008000
  • NTONG20008780//MAJOR CENTROMERE AUTOANTIGEN B (CENTROMERE PROTEIN B) (CENP-B).//1.40E-42//330aa//31%//P27790
  • NTONG20009660//Mus musculus N-RAP mRNA, complete cds.//2.50E-56//393aa//38%//U76618
  • NTONG20009850
  • NTONG20011370
  • NTONG20012220
  • NTONG20014280
  • NTONG20015500//ZINC FINGER PROTEIN 135.//1.40E-128//340aa//64%//P52742
  • NTONG20016120//Oxystyrol-binding protein homologue 1 [Mus musculus domesticus].//3.00E-43//342aa//37%//AJ278263
  • OCBBF10000420
  • OCBBF10000670
  • OCBBF10000860
  • OCBBF10000910//SORBIN.//1.30E-71//145aa//91%//P28220
  • OCBBF10001040
  • OCBBF10001180//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 1, ENDOTHELIAL (B12 PROTEIN).//1.00E-12//124aa//37%//Q13829
  • OCBBF10001190
  • OCBBF10001220//RING CANAL PROTEIN (KELCH PROTEIN).//8.50E-32//274aa//31%//Q04652
  • OCBBF20000130
  • OCBBF20001260
  • OCBBF20002310//PHOSPHOLIPASE A2 INHIBITOR SUBUNIT B PRECURSOR (PLI-B).//3.50E-27//307aa//29%//Q93233
  • OCBBF20002770//EARLY EMBRYOGENESIS ZYG-11 PROTEIN.//1.40E-46//348aa//34%//P21541
  • OCBBF20002870
  • OCBBF20007190//Putative cleavage and polyadenylation specifity factor [Arabidopsis thaliana].//1.00E-142//450aa//53%//M D12712
  • OCBBF20008240//THREONYL-TRNA SYNTHETASE, CYTOPLASMIC (EC 6.1.1.3) (THREONINE-TRNA LIGASE) (THRRS).//1.10E-244//484aa//77%//P26639
  • OCBBF20009040
  • OCBBF20009980
  • OCBBF20010750
  • OCBBF20011010//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//1.10E-133//405aa//55%//Q05481
  • OCBBF20011240//TESTIS SPECIFIC PROTEIN A (ZINC FINGER PROTEIN TSGA).//1.60E-81//391aa//42%//Q63679
  • OCBBF20011400//VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS8.//3.30E-17//199aa//23%//P39702
  • OCBBF20011760//Mus musculus actin-binding protein (ENC-1) mRNA, complete cds.//2.30E-236//527aa//75%//U65079
  • OCBBF20012100//Cavia porcellus phosphatidic acid phosphatase 2a (PAP2a) mRNA, complete cds.//6.30E-29//285aa//29%//AF088283
  • OCBBF20013070
  • OCBBF20014020//Mus musculus NSD1 protein mRNA, complete cds.//Q//886aa//73%//AF064553
  • OCBBF20014080//H. sapiens mRNA for thioesterase II.//3.00E-67//163aa//83%//X86032
  • OCBBF20014940//ubiquitin-protein ligase 1 [Arabidopsis thaliana]//2.00E-15//200aa//30%//AAF36454
  • OCBBF20015270
  • OCBBF20015280//MYOSIN HEAVY CHAIN, SMOOTH MUSCLE ISOFORM (SMMHC).//4.90E-23//415aa//22%//P35748
  • OCBBF20015860//TRANSCRIPTION ELONGATION FACTOR S-II (TFIIS).//7.70E-06//104aa//33%//P49373
  • OCBBF20017060
  • PANCR10000210//PROTEIN DISULFIDE ISOMERASE PRECURSOR (PDI) (EC 5.3.4.1) (PROLYL 4-HYDROXYLASE BETA SUBUNIT) (CELLULAR THYROID HORMONE BINDING PROTEIN) (P55).//9.10E-31//231aa//33%//P05307
  • PANCR10001850
  • PEBLM10000290
  • PEBLM10000340//RNA-BINDING PROTEIN EWS.//1.80E-284//615aa//83%//Q01844
  • PEBLM10000680//ACTIN, CYTOPLASMIC TYPE 5.//1.30E-70//158aa//86%//P53505
  • PEBLM10001440//Trg//2.40E-212//385aa//60%//CAM48220
  • PEBLM10001800
  • PEBLM20000300
  • PEBLM20001120//Homo sapiens nucleotide-binding site protein 1 mRNA, complete cds.//1.90E-127//899aa//34%//AF298547
  • PEBLM20001260
  • PEBLM20001470
  • PEBLM20002130//Mus musculus genes for integrin aM290, hapsin, partial and complete cds.//8.20E-44//246aa//47%//AB036930
  • PEBLM20002480//ZINC FINGER PROTEIN 157.//8.70E-71//210aa//47%//P51786
  • PEBLM20002700//Homo sapiens, tissue-type bone marrow zinc finger protein 4 mRNA, complete cds.//6.70E-237//537aa//80%//AF070651
  • PEBLM20003080//ZINC FINGER PROTEIN 135.//2.40E-133//335aa//65%//P52742
  • PEBLM20003950//ZINC FINGER PROTEIN 165.//3.20E-35//143aa//59%//P49910
  • PEBLM20004790//PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (EC 2.7.1.112) (P59-FYN).//4.70E-264//410aa//95%//P39688
  • PLACE50000370//Homo sapiens mRNA for hVPS11, complete cds.//1.80E-149//281 aa//98%//AB027508
  • PLACE50000580//PUTATIVE IMPORTIN BETA-4 SUBUNIT (KARYOPHERIN BETA-4 SUBUNIT).//9.60E-76//937aa//27%//Q60100
  • PLACE50000670
  • PLACE50000680//C4B-BINDING PROTEIN PRECURSOR (C4BP).//5.10E-09//136aa//30%//P08607
  • PLACE50000800//Human non-lens beta gamma-crystallin like protein (AIM1) mRNA, partial cds.//Q//840aa//99%//U83115
  • PLACE50001050//Mus musculus mRNA for heparan sulfate 6-sulfotransferase 2, complete cds.//6.10E-236//300aa//89%//AB024565
  • PLACE50001130//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//2.20E-23//729aa//24%//P08640
  • PLACE50001530
  • PLACE50001700//DNAK PROTEIN (HEAT SHOCK PROTEIN 70) (HSP70).//3.00E-05//108aa//30%//Q56235
  • PLACE60000440
  • PLACE60000700
  • PLACE60000800
  • PLACE60001370
  • PLACE60002050//TRANSCRIPTIONAL REPRESSOR PROTEIN YY1 (YIN AND YANG 1) (YY-1) (DELTA TRANSCRIPTION FACTOR) (NF-E1).//6.00E-73//212aa//66%//P25490
  • PLACE60002630
  • PLACE60003710
  • PLACE60003790//PUTATIVE PRE-MRNA SPLICING FACTOR RNA HELICASE (DEAH BOX PROTEIN 15) (ATP-DEPENDENT RNA HELICASE #46).//5.30E-104//191aa//99%//Q43143
  • PLACE60004240
  • PLACE60004290
  • PLACE60005230
  • PLACE60005500
  • PLACE60005550//Human (c-myb) gene, complete primary cds, and five complete alternatively spliced cds.//4.60E-20//71aa//66%//U22376
  • PLACE60009530
  • PLACE60012810//Probable acyl-CoA synthetase (EC 6.2.1.-)—Mycobacterium tuberculosis (strain H37RV)//3.00E-11//600aa//24%//C70669
  • PLACE60012940
  • PLACE60014430//Homo sapiens mRNA for MOCS1A & MOCS1B proteins, complete CDSs.//1.60E-146//283aa//98%//AJ224328
  • PLACE60018860//ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE).//1.30E-244//504aa//90%//P26770
  • PLACE60019230
  • PLACE60019250
  • PLACE60020160
  • PLACE60020840//CYTOCHROME B561 (CYTOCHROME B-561).//1.00E-45//211aa//47%//Q95245
  • PLACE60021020
  • PLACE60021510//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//5.00E-140//351aa//61%//P51523
  • PLACE60024190//TRICHOHYALIN.//1.40E-09//299aa//24%//P37709
  • PLACE60026680//Homo sapiens Arg/Abl-interacting protein ArgBP2b (ArgBP2b) mRNA, partial cds.//1.00E-254//484aa//96%//AF049885
  • PLACE60026920
  • PLACE60026990//Human PMS2 related (hPMSR6) mRNA, complete cds.//5.70E-42//112aa//75%//U38980
  • PLACE60029490
  • PLACE60030380//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2).//3.60E-34//335aa//30%//P51523
  • PLACE60030940
  • PLACE60031090
  • PLACE60032040
  • PLACE60033720
  • PLACE60033990//SPIDROIN 1 (DRAGLINE SILK FIBROIN 1) (FRAGMENT).//1.40E-08//234aa//27%//P19837
  • PLACE60037050
  • PLACE60037400
  • PLACE60037450
  • PLACE60038500//Homo sapiens mitochondrial solute carrier mRNA, complete cds.//5.10E-65//171aa//70%//AF155660
  • PLACE60040050
  • PLACE60043120
  • PLACE60043360
  • PLACE60043960
  • PLACE60043970//Takifugu rubripes retinitis pigmentosa GTPase regulator-like protein gene, partial cds.//2.60E-14//329aa//21%//AF286475
  • PLACE60044540//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//1.90E-46//865aa//26%//P08640
  • PLACE60044640//Human placenta (Diff48) mRNA, complete cds.//2.60E-88//414aa//45%//U49187
  • PLACE60044910
  • PLACE60046630
  • PLACE60046870
  • PLACE60047380
  • PLACE60049310
  • PLACE60049930
  • PLACE60050290
  • PROST10001520
  • PROST10001670//SYNAPSIN I (BRAIN PROTEIN 4.1).//2.20E-07//239aa//28%//P17600
  • PROST10002200
  • PROST10002460
  • PROST10002720//Homo sapiens mRNA for calsyntenin-2 (CS2 gene).//7.00E-23//153aa//42%//AJ278018
  • PROST10003430//Numb-binding protein LNXP80//0//732aa//87%//T09457
  • PROST10005260
  • PROST10005360//Homo sapiens contactin associated protein (Caspr) mRNA, complete cds.//1.30E-152//719aa//38%//U87223
  • PROST10005640
  • PROST20000360
  • PROST20000530//60S RIBOSOMAL PROTEIN L13A (23 KDA HIGHLY BASIC PROTEIN).//2.00E-33//73aa//95%//P40429
  • PROST20001760//RD PROTEIN (WL623).//7.30E-12//104aa//41%//P19426
  • PROST20002060
  • PROST20002670
  • PROST20002730//H4(D10S170) PROTEIN.//2.60E-63//118aa//98%//Q16204
  • PROST20002740
  • PROST20003250//Homo sapiens DAZ associated protein 1 (DAZAP1) mRNA, complete cds.//2.50E-150//264aa//98%//AF181719
  • PROST20004630
  • PROST20017390
  • PROST20017960
  • PROST20018230//TRANSCRIPTION FACTOR SP1.//4.60E-59//287aa//42%//Q01714
  • PROST20018990//Human Rar protein mRNA, complete cds.//1.20E-127//278aa//88%//U05227
  • PROST20019980
  • PROST20021620
  • PROST20023380//Cca3 protein//5.20E-68//142aa//94%//T31081
  • PROST20025910
  • PROST20026820//DENTIN MATRIX ACIDIC PHOSPHOPROTEIN 1 PRECURSOR (DENTIN MATRIX PROTEIN-1) (DMP-1) (AG1).//6.90E-05//255aa//27%//Q55188
  • PROST20028420
  • PROST20029600//Human butyrophilin (BTF1) mRNA, complete cds.//2.00E-61//144aa//87%//U90543
  • PROST20031020
  • PROST20031170//DNA BINDING PROTEIN URE-B1 (EC 6.3.2.-).//1.70E-23//282aa//27%//P51593
  • PROST20032100
  • PROST20032320//BETA-GLUCURONIDASE PRECURSOR (EC 3.2.1.31) (BETA-G1).//1.20E-18//46aa//91%//P08236
  • PROST20033020
  • PROST20033030
  • PROST20033380//KINESIN LIGHT CHAIN (KLC).//7.70E-08//146aa//27%//P46824
  • PROST20033400//SERINE/THREONINE-PROTEIN KINASE 9 (EC 2.7.1.-).//1.80E-25//55aa//100%//Q76039
  • PROST20034720//IMMEDIATE-EARLY PROTEIN.//7.80E-11//180aa//24%//Q01042
  • PROST20037320
  • PROST20039220
  • PROST20043320//Homo sapiens mRNA for BAP2-beta protein, complete cds.//3.70E-227//431aa//99%//AB015020
  • PROST20044160//TROPOMYOSIN 5, CYTOSKELETAL TYPE.//7.80E-48//100aa//97%//P21107
  • PROST20044810
  • PROST20051210//PROBABLE PROTEIN PHOSPHATASE 2C T23F11.1 (EC 3.1.3.16) (PP2C).//7.00E-16//74aa//41%//P49596
  • PROST20051430
  • PROST20054260
  • PROST20056040
  • PROST20058800
  • PROST20059190//Human breast cancer, estrogen regulated LIV-1 protein (LIV-1) mRNA, partial cds.//1.50E-28//109aa//55%//U41060
  • PROST20059430
  • PROST20061960
  • PROST20062600//SPLICING FACTOR, ARGININE/SERINE-RICH 4 (PRE-MRNA SPLICING FACTOR SRP75).//2.20E-07//269aa//22%//Q08170
  • PROST20064500//N-HYDROXYARYLAMINE SULFOTRANSFERASE (EC 2.8.2.-) (HAST-I).//9.10E-38//102aa//70%//P50237
  • PROST20067370//H. sapiens mRNA for XIAP associated factor-1.//2.40E-122//223aa//99%//X99699
  • PROST20069880//Mus musculus DXImx48e protein (DXImx48e) mRNA, complete cds.//9.6e-316//750aa//79%//AF229644
  • PROST20072370
  • PROST20072890//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 1, ENDOTHELIAL (B12 PROTEIN).//1.50E-117//314aa//70%//Q13829
  • PROST20073170//Rattus norvegicus zinc finger protein RIN ZF mRNA, complete cds.//1.80E-268//559aa//87%//AF091457
  • PROST20073890//VASCULAR ENDOTHELIAL GROWTH FACTOR PRECURSOR (VEGF) (VASCULAR PERMEABILITY FACTOR) (VPF).//5.30E-33//63aa//98%//P15692
  • PROST20079740//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN CEX) (FRAGMENT).//4.10E-09//97aa//36%//P40603
  • PROST20085160//TROPOMYOSIN, CYTOSKELETAL TYPE (TM30-NM).//2.10E-93//220aa//87%//P12324
  • PROST20094830
  • PUAEN10000570
  • PUAEN10000810
  • PUAEN10001610//GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 1.//2.10E-68//448aa//32%//P25655
  • PUAEN10003220
  • SALGL10000050
  • SALGL10000470//NG36 [Homo sappiens]//3.00E-53//184aa//96%//AAD21811
  • SALGL10000650//POLYHOMEOTIC-PROXIMAL CHROMATIN PROTEIN.//4.60E-08//71aa//43%//P39769
  • SALGL10001570//APOLIPOPROTEIN L PRECURSOR (APO-L).//5.10E-99//338aa//61%//Q14791
  • SKMUS10000140//Polyubiquitin 9—human.//2.10E-199//280aa//96%//M26880
  • SKMUS10000220//NUCLEAR PORE PROTEIN SEH1 HOMOLOG.//2.00E-58//346aa//39%//Q10099
  • SKMUS10000640//Mus musculus RING-finger protein MURF mRNA, complete cds./4.10E-111//348aa//60%//AF294790
  • SKMUS10001040//Homo sapiens mRNA for HEXIM1 protein, complete cds.//2.40E-49//256aa//47%//AB021179
  • SKMUS10001180//Homo sapiens t(3:5)(q25.1:p34) fusion gene NPM-MLF1 mRNA, complete cds.//3.60E-126//258aa//94%//L49054
  • SKMUS10001240
  • SKMUS10001290//ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (EC 5.3.3.2) (IPP ISOMERASE) (ISOPENTENYL PYROPHOSPHATE ISOMERASE).//4.10E-81//227aa//64%//Q13907
  • SKMUS10001770//PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE (EC 2.1.1.77) (PROTEIN-BETA-ASPARTATE METHYLTRANSFERASE) (PIMT) (PROTEIN L-ISOASPARTYL METHYLTRANSFERASE) (L-ISOASPARTYL PROTEIN CARBOXYL METHYLTRANSFERASE).//2.50E-18//213aa//29%//Q26915
  • SKMUS20000740//Homo sapiens methyltransferase C003 (C003) mRNA, complete cds.//8.50E-166//309aa//99%//AF193016
  • SKMUS20001170//Homo sapiens MAGEF1 (MAGEF1) mRNA, complete cds.//1.50E-74//305aa//50%//AF295378
  • SKMUS20002710
  • SKMUS20003430
  • SKMUS20003650//Human (p23) mRNA, complete cds.//7.00E-20//110aa//39%//L24804
  • SKMUS20003900//Homo sapiens 38 kDa Mov34 homolog mRNA, complete cds.//1.20E-152//286aa//99%//U70734
  • SKMUS20004580//Mus musculus N-RAP mRNA, complete cds.//4.50E-160//591aa//56%//U76618
  • SKMUS20004670
  • SKMUS20004680
  • SKMUS20007240//Homo sapiens mRNA for 2-hydroxyphytanoyl-CoA lyase.//2.60E-148//318aa//88%//AJ131753
  • SKMUS20007740//BALBIANI RING PROTEIN 1 (GIANT SECRETORY PROTEIN I-A) (GSP-IA) (FRAGMENT).//1.30E-08//138aa//26%//P02849
  • SKMUS20008470
  • SKMUS20008630//PROBABLE ASPARAGINYL-TRNA SYNTHETASE (EC 6.1.1.22) (ASPARAGINE-TRNA LIGASE) (ASNRS).//1.10E-103//445aa//46%//P52276
  • SKMUS20009020//BRO1 PROTEIN.//2.30E-08//232aa//26%//P48582
  • SKMUS20009330//RNA polymerase III subunit [Homo sapiens]//1.80E-44//216aa//47%//U93868
  • SKMUS20009450
  • SKMUS20009540//Homo sapiens F-box protein Fbx25 (FBX25) mRNA, partial cds.//4.20E-93//263aa//64%//AF174605
  • SKMUS20010080//Mus musculus mRNA for a skeletal muscle and cardiac protein.//1.00E-75//178aa//87%//AJ011118
  • SKMUS20011290//NAD-DEPENDENT METHANOL DEHYDROGENASE (EC 1.1.1.244) (MEDH).//3.70E-45//195aa//32%//P31005
  • SKMUS20011470//Mus musculus RP42 mRNA, complete cds.//1.30E-32//186aa//36%//AF198092
  • SKMUS20013640
  • SKMUS20014920//Zinc finger protein//4.40E-05//153aa//24%//T37771
  • SKMUS20015010
  • SKMUS20015430//Homo sapiens HDCMC29P mRNA, partial cds.//3.50E-128//248aa//97%//AF068295
  • SKMUS20016080
  • SKMUS20016310
  • SKMUS20016340//HIGH MOBILITY GROUP PROTEIN HMG2 (HMG-2).//6.00E-11//170aa//25%//P26583
  • SKMUS20016620//Oryctolagus cuniculus CARP mRNA, complete cds.//2.70E-43//196aa//51%//AF131883
  • SKMUS20016680//Neuron-specific signal trunduction protein Stac//8.30E-33//218aa//38%//NP—058549
  • SKMUS20016710
  • SKNMC10000070
  • SKNMC10000100
  • SKNMC10000190
  • SKNMC10000290
  • SKNMC10001100
  • SKNMC10001590
  • SKNMC10001680
  • SKNMC10002290
  • SKNMC10002510//Homo sapiens MT-ABC transporter (MTABC) mRNA, complete cds.//Q//672aa//93%//AF076775
  • SKNMC10002640
  • SKNMC20000650//ZINC FINGER PROTEIN 136.//7.20E-05//311aa//23%//P52737
  • SKNMC20000970//M. musculus mRNA for protein Htf9C.//9.80E-220//552aa//75%//X56044
  • SKNMC20002240//ZINC FINGER PROTEIN 228.//1.80E-68//226aa//53%//Q9UJU3
  • SKNMC20003050
  • SKNMC20003220//MAJOR CENTROMERE AUTOANTIGEN B (CENTROMERE PROTEIN B) (CENP-B).//3.70E-10//153aa//32%//P07199
  • SKNMC20003560//Mus musculus Max-interacting transcriptional repressor (Mad3) mRNA, complete cds.//1.90E-72//168aa//86%//U32394
  • SKNMC20005930
  • SKNMC20006120
  • SKNMC20010570
  • SKNMC20011130//Rattus norvegicus golgi peripheral membrane protein p65 (GRASP65) mRNA, complete cds.//6.90E-90//244aa//66%//AF015264
  • SKNMC20015030//P-SELECTIN GLYCOPROTEIN LIGAND 1 PRECURSOR (PSGL-1) (SELECTIN P LIGAND).//3.60E-11//152aa//32%//Q62170
  • SKNMC20015550
  • SKNMC20015960//Homo sapiens mRNA for ANKHZN, complete cds.//0//1046aa//95%//AB037360
  • SKNSH10000860
  • SKNSH10001740//ORNITHINE DECARBOXYLASE (EC 4.1.1.17) (ODC).//9.00E-102//352aa//53%//P00860
  • SKNSH10003010//Homo sapiens DRC3 mRNA, complete cds.//3.00E-154//305aa//91%//AF282167
  • SKNSH10003080
  • SKNSH20001510
  • SKNSH20001630
  • SKNSH20003470//CYTOCHROME B2 PRECURSOR (EC 1.1.2.3) (L-LACTATE DEHYDROGENASE (CYTOCHROME)) (L-LACTATE FERRICYTOCHROME C OXIDOREDUCTASE) (L-LCR).//2.60E-07//107aa//32%//P00175
  • SMINT10000160//2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE PRECURSOR (EC 2.4.1.45) (UDP-GALACTOSE-CERAMIDE GALACTOSYLTRANSFERASE) (CERAMIDE UDP-GALACTOSYLTRANSFERASE) (CEREBROSIDE SYNTHASE).//3.80E-71//492aa//33%//Q64676
  • SMINT10000390
  • SMINT10000420//ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 3 (ATP-BINDING CASSETTE TRANSPORTER 3) (ATP-BINDING CASSETTE 3) (ABC-C TRANSPORTER).//2.70E-92//662aa//34%//Q99758
  • SMINT10000540
  • SMINT10000570//Homo sapiens leucocyte immunoglobulin-like receptor-8 (LIR-8) mRNA, complete cds.//5.30E-212//481aa//84%//AF025534
  • SMINT10000710
  • SMINT10001000//PAIRED MESODERM HOMEOBOX PROTEIN 2B (PAIRED-LIKE HOMEOBOX 2B) (PHOX2B HOMEODOMAIN PROTEIN) (NEUROBLASTOMA PHOX) (NBPHOX).//1.60E-05//87aa//39%//Q99453
  • SMINT10001030//Homo sapiens ankyrin repeat-containing protein ASB-2 mRNA, complete-cds.//1.20E-292//546aa//99%//AF159164
  • SMINT10001180
  • SMINT20000180
  • SMINT20000400
  • SMINT20001450//Halocynthia roretzi mRNA for HrPET-3, complete cds.//2.30E-20//125aa//40%//AB029335
  • SMINT20002270
  • SMINT20002390
  • SMINT20002770//BUTYROPHILIN PRECURSOR (BT).//3.20E-51//269aa//41%//P18892
  • SMINT20003960//A kinase anchor protein AKAP-KL isoform 2//5.00E-254//738aa//70%//T09226
  • SMINT20004000//Homo sapiens FRG1 mRNA, complete cds.//7.00E-52//116aa//90%//L76159
  • SMINT20005450//Mus musculus Zfp228 (Znf228) mRNA, complete cds.//1.20E-31//125aa//49%//AF282919
  • SMINT20005580
  • SPLEN10000490
  • SPLEN10000910//Homo sapiens HRIHFB2007 mRNA, partial cds.//5.20E-95//199aa//90%//AB015330
  • SPLEN10001430//HIGH MOBILITY GROUP PROTEIN HMG1 (HMG-1).//3.00E-78//147aa//100%//P09429
  • SPLEN20000200//Human (c-myb) gene, complete primary cds, and five complete alternatively spliced cds.//3.10E-11//64aa//57%//U22376
  • SPLEN20000470
  • SPLEN20000720//ZINC FINGER PROTEIN CKR1.//3.10E-37//235aa//37%//P30373
  • SPLEN20001340//CARBOXYPEPTIDASE S PRECURSOR (EC 3.4.17.4) (YSCS) (GLY-X CARBOXYPEPTIDASE).//3.30E-29//250aa//37%//P27614
  • SPLEN20001970//SPLICING FACTOR, ARGININE/SERINE-RICH 4 (PRE-MRNA SPLICING FACTOR SRP75).//2.70E-14//243aa//28%//Q08170
  • SPLEN20002420
  • SPLEN20002430
  • SPLEN20002670//Rattus norvegicus TGF-beta resistance-associated protein (TRAG) mRNA, complete cds.//Q//559aa//84%//AF305813
  • SPLEN20002700
  • SPLEN20003100
  • SPLEN20003570//Mus musculus RaIGDS-like protein 3 mRNA, complete cds.//8.30E-191//453aa//81%//AF237669
  • SPLEN20004430
  • SPLEN20004960
  • SPLEN20005410
  • STOMA10000470
  • STOMA10000520
  • STOMA10001170
  • STOMA10001330
  • STOMA10001860//CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE (EC 3.1.2.2) (LONG CHAIN ACYL-COA THIOESTER HYDROLASE) (CTE-II).//2.70E-173//328aa//99%//Q00154
  • STOMA20000320
  • STOMA20000880//IG LAMBDA CHAIN C REGIONS.//1.50E-51//105aa//96%//P01842
  • STOMA20001210//Fugu rubripes CCBL1 gene, exons 1 to 12.//1.90E-127//415aa//55%//Y17462
  • STOMA20001880
  • STOMA20002570
  • STOMA20002890
  • STOMA20003960//LIM-ONLY PROTEIN 6 (TRIPLE LIM DOMAIN PROTEIN 6).//3.60E-59//352aa//39%//Q43900
  • STOMA20004780
  • STOMA20004820//1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) delta-2//6.90E-148//325aa//84%//S14113
  • SYNOV10001280//Homo sapiens colon cancer-associated protein Mic1 (MIC1) mRNA, complete cds.//1.1e-316//609aa//97%//AF143536
  • SYNOV10001640
  • SYNOV20001770
  • SYNOV20002910//Arabinogalactan-like protein//2.90E-07//124aa//31%//S52994
  • SYNOV20008200//Trichoplusia ni transposon IFP2.//4.10E-13//254aa//27%//J04364
  • SYNOV20010140//Mus musculus Zfp228 (Znf228) mRNA, complete cds.//2.50E-31//125aa//49%//AF282919
  • SYNOV20011440
  • SYNOV20013740//ZINC FINGER PROTEIN 134.//1.90E-108//332aa//53%//P52741
  • SYNOV20014510//MYOCYTE-SPECIFIC ENHANCER FACTOR 2B (SERUM RESPONSE FACTOR-LIKE PROTEIN 2) (XMEF2) (RSRFR2).//6.40E-140//302aa//88%//Q02080
  • SYNOV20014570
  • SYNOV20016480//THYMIDINE PHOSPHORYLASE PRECURSOR (EC 2.4.2.4) (TDRPASE) (TP) (PLATELET-DERIVED ENDOTHELIAL CELL GROWTH FACTOR) (PD-ECGF) (GLIOSTATIN)./2.80E-35//69aa//100%/P19971
  • TESTI10000230
  • TESTI10000250//M. musculus mRNA for testis-specific protein, DDC8./2.60E-68//462aa//42%//Y09878
  • TESTI10000420//PARAMYOSIN (ANTIGEN SJ97).//2.50E-08//367aa//23%//Q05870
  • TESTI10000510//CYTADHERENCE HIGH MOLECULAR WEIGHT PROTEIN 2 (CYTADHERENCE ACCESSORY PROTEIN 2).//4.00E-13//648aa//22%//P75471
  • TESTI10000550//HOMEOBOX PROTEIN SIX1 (FRAGMENT)./8.90E-11//199aa//30%//Q62231
  • TESTI10000640//Fugu rubripes sex comb on midleg-like 2 protein (SCML2) gene, complete cds.//2.20E-140//513aa//49%//AF146688
  • TESTI10000700//Rattus norvegicus deubiquitinating enzyme Ubp69 (ubp69) mRNA, complete cds.//7.00E-297//618aa//88%//AF106659
  • TESTI10000960
  • TESTI10001250
  • TESTI10001270//POLYCYSTIN PRECURSOR (AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE PROTEIN 1).//3.60E-11//161aa//33%//P98161
  • TESTI10001310//Homo sapiens TCP11 (TCP11) mRNA, complete cds.//1.90E-223//425aa//100%//AF269223
  • TESTI10001380//NEUROENDOCRINE CONVERTASE 3 PRECURSOR (EC 3.4.21.61) (NEC 3) (PC4) (PROHORMONE CONVERTASE 3) (KEX2-LIKE ENDOPROTEASE 3).//1.10E-140//303aa//85%//P29121
  • TESTI10001630
  • TESTI10001680//PROTEIN PHOSPHATASES PP1 REGULATORY SUBUNIT SDS22.//4.30E-14//158aa//35%//P36047
  • TESTI10001790
  • TESTI10001910//Homo sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds.//8.70E-77//274aa//59%//AF204231
  • TESTI20000180
  • TESTI20000440//TRICHOHYALIN.//3.00E-16//476aa//26%//P22793
  • TESTI20001200//Homo sapiens mRNA for zinc finger 3 (ZF3 gene).//6.90E-13//108aa//40%//X60153
  • TESTI20001540//PUTATIVE SERINE/THREONINE-PROTEIN KINASE D1044.3 IN CHROMOSOME III (EC 2.7.1.-).//1.30E-32//103aa//48%//P41951
  • TESTI20001770//INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3 PRECURSOR (ITI HEAVY CHAIN H3) (SERUM-DERIVED HYALURONAN-ASSOCIATED PROTEIN) (SHAP).//5.10E-05//57aa//22%//Q06033
  • TESTI20001790
  • TESTI20001840//SIT4-ASSOCIATING PROTEIN SAP185.//7.90E-08//109aa//33%//P40856
  • TESTI20002070//NIFU-LIKE PROTEIN.//3.60E-43//105aa//80%//Q9ZD61
  • TESTI20002080//Homo sapiens mRNA for Gab2, complete cds.//7.60E-62//222aa//60%//AB018413
  • TESTI20002380
  • TESTI20002530//Homo sapiens A1U mRNA, complete cds.//6.60E-17//220aa//31%//AF188240
  • TESTI20003560//TUBULIN ALPHA-3/ALPHA-7 CHAIN.//2.00E-40//119aa//73%//P05214
  • TESTI20003720
  • TESTI20004350//CALDESMON (CDM).//1.20E-09//180aa//23%//P12957
  • TESTI20004620
  • TESTI20005200
  • TESTI20005910//ADENYLATE KINASE, CHLOROPLAST (EC 2.7.4.3) (ATP-AMP TRANSPHOSPHORYLASE).//3.60E-34//209aa//37%//P43188
  • TESTI20006000//RESTIN (CYTOPLASMIC LINKER PROTEIN-170 ALPHA-2) (CLIP-170) (REED-STERNBERG INTERMEDIATE FILAMENT ASSOCIATED PROTEIN).//6.80E-21//196aa//32%//P30622
  • TESTI20006270
  • TESTI20006710
  • TESTI20006950//KINESIN HEAVY CHAIN.//7.80E-07//391aa//22%//P21613
  • TESTI20006990//KINESIN-LIKE PROTEIN KIF2 (KINESIN-2) (HK2).//2.00E-184//539aa//63%//Q00139
  • TESTI20007070//DOUBLESEX PROTEIN, MALE-SPECIFIC.//3.00E-13//163aa//31%//P23023
  • TESTI20007620//DRA PROTEIN (DOWN-REGULATED IN ADENOMA).//1.60E-09//88aa//38%//P40879
  • TESTI20007840//PUTATIVE IMPORTIN BETA-4 SUBUNIT (KARYOPHERIN BETA-4 SUBUNIT).//6.00E-89//092aa//26%//Q60100
  • TESTI20008190
  • TESTI20008300
  • TESTI20008490//MYOSIN HEAVY CHAIN, CLONE 203 (FRAGMENT).//4.90E-09//331aa//24%//P39922
  • TESTI20008830//MYOSIN-BINDING PROTEIN C, SLOW-TYPE (SLOW MYBP-C) (C-PROTEIN, SKELETAL MUSCLE SLOW-ISOFORM)./4.20E-88//162aa//100%//Q00872
  • TESTI20009090
  • TESTI20009510
  • TESTI20009700
  • TESTI20010080
  • TESTI20010490//HYPOTHETICAL ZINC FINGER PROTEIN KIAA0961.//2.70E-155//504aa//56%//Q9Y2G7
  • TESTI20010820
  • TESTI20011340
  • TESTI20011410//Rattus norvegicus actin-filament binding protein Frabin mRNA, complete cds.//0//766aa//83%//AF038388
  • TESTI20011800//TRICHOHYALIN.//5.80E-07//322aa//22%//Q07283
  • TESTI20012370//RING CANAL PROTEIN (KELCH PROTEIN).//1.60E-38//438aa//26%//Q04652
  • TESTI20012690//DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL PRECURSOR (EC 2.3.1.12) (E2) (PDC-E2) (70 KDA MITOCHONDRIAL AUTOANTIGEN OF PRIMARY BILIARY CIRRHOSIS) (PBC) (M2 ANTIGEN COMPLEX 70 KDA SUBUNIT).//3.40E-308//575aa//99%//P10515
  • TESTI20013060
  • TESTI20013300//Homo sapiens NY-REN-60 antigen mRNA, partial cds.//1.10E-172//315aa//99%//AF155116
  • TESTI20013450//M. musculus Tenr mRNA for RNA binding protein.//3.00E-273//576aa//88%//X84693
  • TESTI20013520
  • TESTI20014120//TRICHOHYALIN.//1.40E-28//370aa//27%//P37709
  • TESTI20014200//D. melanogaster mRNA for putative organic cation transporter, 2064 bp.//4.20E-54//357aa//33%//Y12400
  • TESTI20015110//MYOSIN II HEAVY CHAIN, NON MUSCLE.//3.50E-07//255aa//24%//P08799
  • TESTI20015120//TOM1 (target of myb 1)//1.00E-57//245aa//56%//NP—005479
  • TESTI20015560//ZINC FINGER PROTEIN 151 (MYC-INTERACTING ZINC FINGER PROTEIN) (MIZ-1 PROTEIN).//9.50E-16//278aa//28%//Q13105
  • TESTI20015930
  • TESTI20016210
  • TESTI20016610//DYNEIN BETA CHAIN, FLAGELLAR OUTER ARM.//1.10E-17//432aa//25%//Q39565
  • TESTI20016650//IMMEDIATE-EARLY PROTEIN.//9.50E-06//111aa//28%//Q01042
  • TESTI20016710
  • TESTI20017580
  • TESTI20017660
  • TESTI20017920
  • TESTI20018150//GASTRULA ZINC FINGER PROTEIN XLCGF7.1 (FRAGMENT).//7.20E-13//98aa//37%//P18735
  • TESTI20018260
  • TESTI20018270//TRANSKETOLASE (EC 2.2.1.1) (TK) (P68).//6.90E-230//614aa//67%//P40142
  • TESTI20018290
  • TESTI20018520//Homo sapiens contactin associated protein (Caspr) mRNA, complete cds.//5.40E-167//724aa//40%//U87223
  • TESTI20018620
  • TESTI20018690//Xenopus laevis bicaudal-C (Bic-C) mRNA, complete cds.//1.20E-08//189aa//30%//AF224746
  • TESTI20018790//ZINC FINGER PROTEIN 157.//8.70E-104//443aa//45%//P51786
  • TESTI20018980
  • TESTI20019500
  • TESTI20019680
  • TESTI20019910
  • TESTI20020020
  • TESTI20020480
  • TESTI20020570//Human actin-like peptide mRNA, partial cds.//6.10E-140//307aa//88%//U20582
  • TESTI20020810//HYPOTHETICAL 80.0 KDA PROTEIN IN POL1-RAS2 INTERGENIC REGION.//5.30E-40//235aa//35%//P50944
  • TESTI20020900
  • TESTI20021050//MICRONUCLEAR LINKER HISTONE POLYPROTEIN (MIC LH) [CONTAINS: LINKER HISTONE PROTEINS ALPHA, BETA, DELTA AND GAMMA].//3.90E-11//365aa//24%//P40631
  • TESTI20021490//ZINC FINGER PROTEIN 131 (FRAGMENT).//5.30E-191//347aa//99%//P52739
  • TESTI20022230//Chlamydomonas reinhardtii strain 1132D-flagellar protofilament ribbon protein (RIB43a) mRNA, complete cds.//7.70E-12//137aa//31%//AF196576
  • TESTI20022450
  • TESTI20022510
  • TESTI20022560//GUANYLATE KINASE (EC 2.7.4.8) (GMP KINASE).//2.20E-20//88aa//31%//Q64520
  • TESTI20022640
  • TESTI20022940//MOB2 PROTEIN (MPS1 BINDER 2).//4.80E-16//133aa//31%//P43563
  • TESTI20023610
  • TESTI20023690
  • TESTI20024150
  • TESTI20024230//PISTIL-SPECIFIC EXTENSIN-LIKE PROTEIN PRECURSOR (PELP).//8.40E-15//155aa//34%//Q03211
  • TESTI20024610//TRICHOHYALIN.//3.60E-13//423aa//23%//P37709
  • TESTI20024650//FIBROIN HEAVY CHAIN PRECURSOR (FIB-H) (FRAGMENTS).//4.70E-06//142aa//33%//P05790
  • TESTI20024670
  • TESTI20024980//Danio rerio p55-related MAGUK protein DLG3 (dlg3) mRNA, complete cds.//2.00E-221//532aa//75%//AF124435
  • TESTI20025160//MELANOMA-ASSOCIATED ANTIGEN B1 (MAGE-B1 ANTIGEN) (MAGE-XP ANTIGEN) (DAM10).//1.40E-89//349aa//54%//P43366
  • TESTI20025440
  • TESTI20025800
  • TESTI20026320
  • TESTI20026760//ZINC-BINDING PROTEIN A33.//1.60E-38//235aa//37%//Q02084
  • TESTI20026980
  • TESTI20027000
  • TESTI20027070//PLASMA-CELL MEMBRANE GLYCOPROTEIN PC-1 [INCLUDES: ALKALINE PHOSPHODIESTERASE I (EC 3.1.4.1); NUCLEOTIDE PYROPHOSPHATASE (EC 3.6.1.9) (NPPASE)].//1.50E-50//406aa//33%//P22413
  • TESTI20027290//Homo sapiens mRNA for oligophrenin 1.//2.50E-56//393aa//38%//AJ001189
  • TESTI20027890//ZINC FINGER PROTEIN 33A (ZINC FINGER PROTEIN KOX31) (KIAA0065) (HA0946) (FRAGMENT).//9.40E-91//472aa//42%//Q06730
  • TESTI20028060
  • TESTI20028400
  • TESTI20028660
  • TESTI20029120//DUAL-SPECIFICITY TYROSINE-(Y)-PHOSPHORYLATION REGULATED KINASE (EC 2.7.1.-) (PROTEIN KINASE MINIBRAIN HOMOLOG) (HP86).//1.90E-47//253aa//41%//Q13627
  • TESTI20029650
  • TESTI20030050//Mus musculus taube nuss mRNA, complete cds.//1.70E-119//260aa//91%//AF222802
  • TESTI20030370
  • TESTI20030590//TESTIS-SPECIFIC PROTEIN PBS13.//1.70E-33//117aa//61%//Q01755
  • TESTI20030710//Homo sapiens C2H2 (Kruppel-type) zinc finger protein mRNA, complete cds.//9.80E-18//139aa//46%//AF159567
  • TESTI20030740//TRICHOHYALIN.//8.30E-12//368aa//24%//P22793
  • TESTI20031090//VACUOLAR PROTEIN 8.//3.80E-23//367aa//27%//P39968
  • TESTI20031170//Tektin A1 [Strongylocentrotus purpuratus]//3.40E-91//397aa//45%//M97188
  • TESTI20031300
  • TESTI20031520
  • TESTI20031930
  • TESTI20031960
  • TESTI20032280
  • TESTI20032550
  • TESTI20032800
  • TESTI20032990
  • TESTI20033250//SALIVARY PROLINE-RICH PROTEIN PRECURSOR (CLONE CP7) [CONTAINS: BASIC PEPTIDE P-F] (FRAGMENT).//4.50E-05//138aa//28%//P02812
  • TESTI20033270//Testis-specific protein [Homo sapiens].//1.00E-22//120aa//47%//NP—067063
  • TESTI20033540//TRICHOHYALIN.//1.80E-13//443aa//22%//P37709
  • TESTI20033560
  • TESTI20033760
  • TESTI20034130//Zinc finger protein 106//9.30E-263//781aa//66%//T14273
  • TESTI20034180
  • TESTI20034190//Homo sapiens very long-chain acyl-CoA synthetase (BG1) mRNA, complete cds.//3.00E-131//468aa//53%//AF179481
  • TESTI20034980//TRIPLE FUNCTIONAL DOMAIN PROTEIN//1.00E-77//250aa//55%//Q75962
  • TESTI20035120//SYNAPTONEMAL COMPLEX PROTEIN 1 (SCP-1 PROTEIN).//9.30E-06//459aa//20%//Q62209
  • TESTI20035410
  • TESTI20035510//Proliferating-cell nucleolar antigen P120-like protein—Archaeoglobus fulgidus.//3.00E-12//200aa//35%//F69504
  • TESTI20035740//A-KINASE ANCHOR PROTEIN 150 (AKAP 150) (CAMP-DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT II HIGH AFFINITY BINDING PROTEIN) (P150) (FRAGMENT).//4.50E-09//357aa//21%//P24587
  • TESTI20035800
  • TESTI20035890
  • TESTI20036250//IMMEDIATE-EARLY PROTEIN.//1.60E-07//120aa//35%//Q01042
  • TESTI20036490//GLYCOPROTEIN X PRECURSOR.//7.40E-06//107aa//31%//P28968
  • TESTI20037270
  • TESTI20037810
  • TESTI20038940
  • TESTI20039140//Tektin A11//2.10E-68//410aa//36%//A46170
  • TESTI20039980//T-CELL RECEPTOR BETA CHAIN ANA 11.//4.40E-13//123aa//40%//P06333
  • TESTI20040000//Rattus norvegicus cca2 mRNA, complete ods.//5.60E-82//179aa//86%//AB000199
  • TESTI20040310
  • TESTI20041110
  • TESTI20041220//Babesia bigemina 200 kDa antigen p200 mRNA, partial cds.//4.60E-05//481aa//19%//AF142406
  • TESTI20042070//Columba livia mRNA for 5′-nucleotidase.//8.20E-113//317aa//67%//AJ131243
  • TESTI20042290//MHC CLASS II TRANSACTIVATOR CIITA.//6.30E-05//89aa//43%//P79621
  • TESTI20042430
  • TESTI20042870//X INACTIVE SPECIFIC TRANSCRIPT PROTEIN (FRAGMENT).//2.40E-06//155aa//32%//P27571
  • TESTI20042950//AMINOPEPTIDASE B (EC 3.4.11.6) (ARGINYL AMINOPEPTIDASE) (ARGININE AMINOPEPTIDASE) (CYTOSOL AMINOPEPTIDASE IV) (AP-B).//4.40E-19//141aa//33%//Q09175
  • TESTI20047120//POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE IK (EC 3.6.1.-) (FRAGMENT).//1.00E-86//169aa//98%//Q60423
  • TESTI20049290
  • TESTI20049820//CGMP-DEPENDENT PROTEIN KINASE 1, ALPHA ISOZYME (EC 2.7.1.37) (CGK 1 ALPHA) (CGKI-ALPHA).//6.60E-07//187aa//26%//Q13976
  • TESTI20049940
  • TESTI20051550
  • TESTI20052680//Rattus norvegicus RSD-6 mRNA, complete cds.//4.20E-61//261aa//55%//AF271155
  • TESTI20053960//ZINC FINGER PROTEIN 132.//0//589aa//99%//P52740
  • TESTI20054080//SER/THR-RICH PROTEIN T10 IN DGCR REGION.//4.90E-117//263aa//82%//P54797
  • TESTI20054920
  • TESTI20055840//Homo sapiens Tandem PH Domain Containing Protein-1 mRNA, complete cds.//2.70E-162//331aa//92%//AF286160
  • TESTI20056900//ENVELOPE GLYCOPROTEIN GP340 (MEMBRANE ANTIGEN) (MA) [CONTAINS: GLYCOPROTEIN GP220].//1.50E-06//171aa//32%//P03200
  • TESTI20057310//CHROMOSOME SCAFFOLD PROTEIN SCII.//1.90E-05//297aa//20%//Q90988
  • TESTI20057420//ENDOZEPINE-RELATED PROTEIN PRECURSOR (MEMBRANE-ASSOCIATED DIAZEPAM BINDING INHIBITOR) (MA-DBI).//5.20E-225//501aa//83%//P07106
  • TESTI20058600//MYELOID UPREGULATED PROTEIN.//2.20E-68//167aa//74%//Q35682
  • TESTI20062380
  • TESTI20062550
  • TESTI20064250
  • TESTI20064830//Homo sapiens RAN binding protein 16 mRNA, complete cds.//5.00E-163//414aa//64%//AF064729
  • TESTI20065720//PROTEIN D52 (N8 PROTEIN).//1.00E-22//129aa//46%//P55327
  • TESTI20067740
  • TESTI20068660//Homo sapiens infertility-related sperm protein mRNA, complete cds.//5.90E-197//365aa//99%//AF311312
  • TESTI20068720
  • TESTI20069780
  • TESTI20069790
  • TESTI20071830//Homo sapiens transcriptional intermediary factor 1 gamma mRNA, complete cds.//1.40E-125//233aa//99%//AF119043
  • TESTI20073580
  • TESTI20074020
  • TESTI20074640//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4) (HTF1).//3.20E-119//428aa//45%//Q03923
  • TESTI20074660//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//1.30E-194//509aa//68%//Q05481
  • TESTI20074800
  • TESTI20076130
  • TESTI20077490
  • TESTI20077500
  • TESTI20078140//D7 PROTEIN.//1.10E-25//99aa//49%//P13007
  • TESTI20078640//Homo sapiens zinc finger protein ZNF232, exon 4 and complete cds.//2.60E-61//119aa//99%//AF080171
  • TESTI20078670//RING CANAL PROTEIN (KELCH PROTEIN).//8.90E-09//269aa//20%//Q04652
  • TESTI20078720//INTRACELLULAR PROTEIN TRANSPORT PROTEIN US01.//2.90E-17//417aa//24%//P25386
  • TESTI20079510//NEURAL CELL ADHESION MOLECULE, 140 KDA ISOFORM PRECURSOR (N-CAM 140) (NCAM-140) (CD56 ANTIGEN).//Q//723aa//96%//P13591
  • TESTI20080200//DPY-19 PROTEIN.//7.50E-114H/621 aa//38%//P34413
  • TESTI20080330
  • TESTI20081390
  • TESTI20081440
  • TESTI20082340
  • TESTI20082400
  • TESTI20083430
  • TESTI20083870//CALCINEURIN B-LIKE PROTEIN (CBLP).//1.80E-73//169aa//82%//P28470
  • TESTI20084400
  • TESTI20086570//MELANOMA-ASSOCIATED ANTIGEN B4 (MAGE-B4 ANTIGEN).//4.20E-88//347aa//52%//Q15481
  • TESTI20087740
  • TESTI20088470
  • TESTI20136910
  • TESTI20138320//Xenopus laevis transketolase mRNA, complete cds.//1.30E-128//315aa//75%//AF270484
  • TESTI20140360//XAA-PRO DIPEPTIDASE (EC 3.4.13.9) (X-PRO DIPEPTIDASE) (PROLINE DIPEPTIDASE) (PROLIDASE) (IMIDODIPEPTIDASE).//1.40E-55//111aa//98%//P12955
  • TESTI20177400
  • TESTI30000020//L. mexicana Imsap2 gene for secreted acid phosphatase 2 (SAP2).//2.00E-11//361aa//24%//Z46970
  • THYMU10000020//Homo sapiens mRNA for Golgi protein (GPP34 gene).//2.20E-135//274aa//95%//AJ296152
  • THYMU10000320
  • THYMU10000830//SUCCINATE DEHYDROGENASE [UBIOUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL PRECURSOR (EC 1.3.5.1) (FP) (FLAVOPROTEIN SUBUNIT OF COMPLEX II).//7.30E-84//185aa//87%//P31040
  • THYMU10001050
  • THYMU10001760//SIALOADHESIN PRECURSOR (SER).//2.50E-42//127aa//71%//Q62230
  • THYMU10002910//Homo sapiens AP-4 adaptor complex beta4 subunit mRNA, complete cds.//1.30E-64//129aa//97%//AF092094
  • THYMU10003290
  • THYMU10003590//BETA-CHIMAERIN//2.00E-23//200aa//31%//P52757
  • THYMU10003660
  • THYMU10003820
  • THYMU10004590//T-CELL-SPECIFIC TRANSCRIPTION FACTOR 1 (TCF-1) (T-CELL FACTOR 1) (TRANSCRIPTION FACTOR-7).//3.70E-89//172aa//97%//Q00417
  • THYMU10004730
  • THYMU10004910//Homo sapiens protein serine/threonine phosphatase 4 regulatory subunit 1 (PP4R1) mRNA, complete cds.//3.70E-49//144aa//65%//AF111106
  • THYMU10005270
  • THYMU10005580//Homo sapiens Sec22 homolog mRNA, complete cds.//7.00E-139//264aa//98%//AF100749
  • THYMU20001400
  • THYMU20002360
  • THYMU20003170//Homo sapiens topoisomerase II alpha-4 (TOP2A) mRNA, partial cds.//5.80E-09//92aa//42%//AF285159
  • THYMU20003690//Mus musculus syntrophin-associated serine-threonine protein kinase mRNA, complete cds.//3.20E-189//481aa//73%//AF077818
  • TRACH10000180
  • TRACH10000300//Anabaena PCC7120 hetC gene, complete cds.//7.00E-12//200aa//29%//U55386
  • TRACH10000570
  • TRACH10000630//CDM PROTEIN (6C6-AG TUMOR-ASSOCIATED ANTIGEN) (DXS1357E).//5.00E-124//246aa//100%//P51572
  • TRACH10000740//Ig delta chain (WIE)//6.90E-251//513aa//90%//S17597
  • TRACH10001000//Oryctolagus cuniculus PiUS mRNA, complete cds.//6.50E-33//68aa//95%//U74297
  • TRACH10001060
  • TRACH10001250//Ig delta chain (WIE)/1.60E-233//513aa//85%//S17597
  • TRACH10001400
  • TRACH20000150//DPP2C1//4.70E-05//152aa//30%//AMC28998
  • TRACH20000790//Xenopus laevis Churchill protein mRNA, complete cds.//4.10E-47//112aa//71%//AF238862
  • TRACH20001850
  • TRACH20001960
  • TRACH20002350
  • TRACH20002370//ZINC FINGER PROTEIN 184 (FRAGMENT).//5.40E-61//275aa//38%//Q99676
  • TRACH20002500//HYPOTHETICAL 65.2 KDA TRP-ASP REPEATS CONTAINING PROTEIN D2030.9 IN CHROMOSOME I.//1.10E-82//375aa//42%//P90794
  • TRACH20002890//GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 (GRB7 ADAPTER PROTEIN) (EPIDERMAL GROWTH FACTOR RECEPTOR GRB-7).//3.90E-188//346aa//98%//Q03160
  • TRACH20003930//Rattus norvegicus matrin 3 mRNA, complete cds.//4.40E-192//371aa//96%//M63485
  • TRACH20004110
  • TRACH20004200//MAJOR SURFACE-LABELED TROPHOZOITE ANTIGEN PRECURSOR.//4.40E-06//96aa//33%//P21849
  • TRACH20004610
  • TRACH20004720//1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2 (EC 4.4.1.14) (ACC SYNTHASE 2) (S-ADENOSYL-L-METHIONINE METHYLTHIOADENOSINE-LYASE 2) (ACS-2).//5.40E-56//396aa//31%//P18485
  • TRACH20004960//Rattus norvegicus kidney-specific protein (KS) mRNA, complete cds.//2.90E-282//573aa//88%//AF062389
  • TRACH20004970//Transacylases//7.70E-11//151aa//32%//AAB94954
  • TRACH20006650//Rattus norvegicus mRNA for putative integral membrane transport protein (UST1r).//3.30E-187//552aa//62%//Y09945
  • TRACH20006750//RADIAL SPOKE PROTEIN 3.//1.90E-50//156aa//48%//P12759
  • TRACH20007670
  • TRACH20007800//Homo sapiens PTH-responsive osteosarcoma B1 protein (B1) mRNA, complete cds.//8.40E-230//339aa//98%//AF095771
  • TRACH20008940//PROTEIN TSG24 (MEIOTIC CHECK POINT REGULATOR).//1.50E-202//384aa//97%//P53995
  • TRACH20008980
  • TRACH20009260//PROBABLE OXIDOREDUCTASE EPHD (EC 1.-.-.-).//5.80E-22//201 aa//33%//Q10402
  • TRACH20009440//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10) (HPF7).//3.80E-07//89aa//39%//Q05481
  • TRACH20011920
  • TRACH20012890//SEX-LETHAL PROTEIN HOMOLOG.//1.20E-07//115aa//33%//Q17310
  • TRACH20013950//Homo sapiens NY-REN-25 antigen mRNA, partial cds.//2.20E-50//104aa//56%//AF155103
  • TRACH20014000
  • TRACH20015920
  • TRACH20016070
  • UMVEN10001220
  • UMVEN20001330//RABPHILIN-3A.//2.00E-18//272aa//30%//P47709
  • UTERU10000770//GAMETOGENESIS EXPRESSED PROTEIN GEG-154.//5.30E-33//73aa//97%//P50636
  • UTERU10000960//VACUOLAR ATP SYNTHASE SUBUNIT H (EC 3.6.1.34) (V-ATPASE H SUBUNIT) (V-ATPASE M9.2 SUBUNIT) (9.2 KDA MEMBRANE ACCESSORY PROTEIN).//1.60E-15//68aa//51%//Q15342
  • UTERU10001600//ZINC FINGER PROTEIN 191.//3.20E-90//346aa//52%//Q14754
  • UTERU10001920
  • UTERU20000470//Homo sapiens neuropilin-2(a0) mRNA, complete cds.//5.00E-20//61aa//80%//AF022859
  • UTERU20003380
  • UTERU20003930
  • UTERU20004850//X-linked retinopathy protein//1.10E-16//97aa//51%//A46010
  • UTERU20005410
  • UTERU20005690
  • This application claims the benefit of priority of Japanese Application No. 2001-328381 filed Sep. 14, 2001, and U.S. Provisional Application No. 60/350,435 filed Jan. 24, 2002, the respective disclosures of which Japanese application and U.S. provisional application are hereby incorporated by reference herein.

Claims (14)

1. A polynucleotide selected from the group consisting of the following (a) to (g):
(a) a polynucleotide comprising a protein-coding region of the nucleotide sequence of any one of SEQ ID NOs: 1 to 1639;
(b) a polynucleotide encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 1640 to 3278;
(c) a polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of any one of SEQ ID NOs: 1640 to 3278, wherein, in said amino acid sequence, one or more amino acids have been substituted, deleted, inserted, and/or added, and wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide comprising the selected amino acid sequence;
(d) a polynucleotide hybridizing to a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NOs: 1 to 1639, wherein said nucleotide sequence encodes a polypeptide functionally equivalent to a polypeptide encoded by the selected nucleotide sequence;
(e) a polynucleotide comprising a nucleotide sequence encoding a partial amino acid sequence of a polypeptide encoded by the polynucleotide according to any one of (a) to (d);
(f) a polynucleotide comprising a nucleotide sequence having at least 70% identity to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1639; and
(g) a polynucleotide comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1639.
2. A polypeptide encoded by the polynucleotide of claim 1, or a partial peptide thereof.
3. An antibody binding to the polypeptide or the peptide of claim 2.
4. A method for immunologically assaying the polypeptide or the peptide of claim 2, said method comprising the steps of contacting the polypeptide or the peptide of claim 2 with an antibody binding to the polypeptide of claim 2, and observing the binding between the two.
5. A vector comprising the polynucleotide of claim 1.
6. A transformant carrying the polynucleotide of claim 1.
7. A transformant carrying the polynucleotide of claim 1.
8. A method for producing a polypeptide, said method comprising the steps of culturing the transformant of claim 7 and recovering an expression product.
9. An oligonucleotide comprising at least 15 nucleotides, said oligonucleotide comprising a nucleotide sequence complementary to the nucleotide sequence of any one of SEQ ID NOs: 1 to 1639 or to a complementary strand thereof.
10. A method for synthesizing a polypeptide, said method comprising utilizing the oligonucleotide of claim 9.
11. A method for detecting a polypeptide, said method comprising utilizing the oligonucleotide of claim 9.
12. An antisense polynucleotide against the polynucleotide of claim 1 or a part thereof.
13. A method for detecting a polypeptide, said method comprising the following steps of:
a) incubating a target polynucleotide with the oligonucleotide of claim 9 under hybridizable conditions, and
b) detecting hybridization of the target polynucleotide with the oligonucleotide of claim 9.
14. A database of polynucleotides and/or polypeptides, said database comprising information on at least one of the nucleotide sequences of SEQ ID NOs: 1 to 1639 and/or on at least one of the amino acid sequences of SEQ ID NOs: 1640 to 3278.
US11/166,372 2001-09-14 2005-06-27 Novel full-length cDNA Abandoned US20070015163A1 (en)

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JP2001-328381 2001-09-14
JP2001328381A JP2003088388A (en) 2001-09-14 2001-09-14 NEW FULL-LENGTH cDNA
US35043502P 2002-01-24 2002-01-24
US10/094,749 US6979557B2 (en) 2001-09-14 2002-03-12 Full-length cDNA
US11/166,372 US20070015163A1 (en) 2001-09-14 2005-06-27 Novel full-length cDNA

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