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US20050235542A1 - Microtome for producing thin sections - Google Patents

Microtome for producing thin sections Download PDF

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Publication number
US20050235542A1
US20050235542A1 US11/103,596 US10359605A US2005235542A1 US 20050235542 A1 US20050235542 A1 US 20050235542A1 US 10359605 A US10359605 A US 10359605A US 2005235542 A1 US2005235542 A1 US 2005235542A1
Authority
US
United States
Prior art keywords
microtome
magazine
cartridge
sample holder
cutting knife
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/103,596
Other languages
English (en)
Inventor
Rolf Metzner
Roland Walter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leica Biosystems Nussloch GmbH
Original Assignee
Leica Microsystems Nussloch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leica Microsystems Nussloch GmbH filed Critical Leica Microsystems Nussloch GmbH
Assigned to LEICA MICROSYSTEMS NUSSLOCH GMBH reassignment LEICA MICROSYSTEMS NUSSLOCH GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: METZNER, ROLF, WALTER, ROLAND
Publication of US20050235542A1 publication Critical patent/US20050235542A1/en
Assigned to LEICA BIOSYSTEMS NUSSLOCH GMBH reassignment LEICA BIOSYSTEMS NUSSLOCH GMBH CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: LEICA MICROSYSTEMS NUSSLOCH GMBH
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

Definitions

  • the invention relates to a microtome having the features of the preamble of claim 1 .
  • WO 00/62035 A1 discloses such a microtome having an automatic function sequence.
  • the sample, embedded in a cartridge, is provided with an individual identification code and automatically fixed to a sample holder.
  • the information contained in the code is read.
  • the thin sections corresponding to the code are prepared and deposited on an object carrier. After that, the cartridge is removed from the sample holder, if appropriate indexed further and kept in a collecting container.
  • the thin sections on the object carrier are prepared further and evaluated one after another by image analysis. The images recorded are stored. If further thin sections are needed from a specific sample, the corresponding cartridge has to be found from the collecting container and introduced into the system again.
  • DE 101 54 843 A1 discloses a microtome in which an indexed cartridge is fixed manually in a sample holder. The sample holder with the cartridge is moved relative to the cutting knife of the microtome. During each new cutting movement, the code applied to the cartridge is read by a reading device fitted to the microtome housing and supplied to a printer in order to label an object carrier. The thin section produced in each case is deposited manually on the object carrier printed in parallel therewith. In this way, confusion when assigning thin section and labeled object carrier is minimized.
  • the coded information applied to the cartridge can relate both to statements about the sample and about the preparation technique and the execution of the section.
  • An apparatus for the corresponding labeling of cartridges or object carriers is disclosed by DE 101 15 065 A1.
  • the invention was based on the object of rationalizing the operations of sample preparation and indexing, sample storage and thin section creation in a microtome and nevertheless of largely ruling out the risk of confusion when evaluating the samples.
  • the filled and likewise indexed magazines can be kept in a space-saving manner and permit rapid access to selected cartridges. If the magazines are stored in a refrigerated housing or a refrigerated chamber, temperature-sensitive samples can also be stored securely over a relatively long time period and kept in stock for subsequent examination. In this case, it is advantageous if the magazine is stored in a refrigerated or insulated chamber on the microtome during the production of the thin sections.
  • microtome An exemplary embodiment of the microtome according to the invention is illustrated schematically in the drawing and will be described in more detail in the following text by using the figures, further advantages being brought out.
  • FIG. 1 An exemplary embodiment of the microtome according to the invention is illustrated schematically in the drawing and will be described in more detail in the following text by using the figures, further advantages being brought out.
  • FIG. 1 shows an overall view of the microtome with peripheral devices
  • FIG. 2 shows a handling device with magazine on the microtome
  • FIG. 3 shows an empty cartridge with identification area
  • FIG. 4 shows a cartridge with embedded sample and individual cartridge code.
  • FIG. 1 an overall view of the microtome is shown schematically by using function blocks.
  • a handling device 50 with magazine 60 is connected by a handling device control line 13 to a control device 10 .
  • the latter is connected via a microtome control line 12 to the microtome 30 and via an object carrier printer control line 11 to an object carrier printer 20 , and monitors and controls the functional sequences of the microtome 30 .
  • the control device 10 can in this case be a separate higher-order computer system, as illustrated in FIG. 1 , or also, in a manner not further illustrated, integrated in the object carrier printer 20 or in a housing, not illustrated, including the microtome 30 and the handling device 50 .
  • the cutting movement is produced by a rotating disk 35 .
  • the sample 42 embedded in a cartridge 40 and to be microtomed is inserted by a handling device 50 into the sample holder 34 in a depression 36 in the rotatably mounted disk 35 .
  • the code stored on the cartridge 40 is read and registered by the control device 10 .
  • the functioning of the handling device 50 will be described in more detail later by using FIG. 2 .
  • the sample 42 is moved from an initial position in the area of the handling device 50 , guided rotationally past the cutting knife 33 fixed in the knife holder 32 and moved into an end position corresponding to the initial position.
  • the object carrier printer 20 removes an object carrier 25 from the object carrier supply 21 and, by using pre-definitions from the control device 10 , creates on the object carrier 25 an identifier which ensures an assignment to the sample 42 just microtomed.
  • the object carrier 25 printed in this way is provided at the object carrier ejector 22 , where the thin section is deposited manually or automatically on the object carrier 25 .
  • the feed device 31 is moved forward in the direction of the rotatably mounted disk 35 by a value predefined by the control device 10 which corresponds to the required thin section thickness, and the procedure just described is repeated.
  • Manual operation of the object carrier printer 20 or of the control device 10 is possible via the input device 23 and can be monitored via the display device 24 .
  • an operator is able to input corrections to the cutting speed or the cutting window or to improve the production of the section in this way and to initiate the renewed production of thin sections.
  • the procedures are repeated until either the thin section produced has the required quality or the desired number of thin sections have been produced from the sample 42 just inserted and have been deposited on the correspondingly printed object carriers 25 .
  • FIG. 2 shows a handling device 50 with magazine 60 fitted to a microtome.
  • the magazine 60 is introduced manually or automatically into a refrigerated/insulated housing 55 , which can be a constituent part of the handling device 50 .
  • a magazine code reading device 53 fitted to or in the refrigerated/insulated housing 55 reads a magazine code 62 applied to the magazine 60 and transmits it to the control device 10 .
  • the magazine code 62 is evaluated there.
  • the magazine 60 there is a relatively large number of prepared cartridges, not further illustrated, arranged one after another in partitions 61 .
  • the magazine 60 is stored within the refrigerated/insulated housing 55 such that it can be displaced in a magazine guide 63 and is moved to a predetermined initial position by means of control predefinitions from the control device 10 in accordance with the evaluated magazine code 62 .
  • a gripper 51 which is fixed to a displacer 52 , a cartridge 40 with embedded sample 42 is then introduced laterally into the sample holder 34 by means of a translational movement.
  • the selected cartridge 40 as it is guided out, is led past a cartridge code reading device 54 with its identification area 43 described in more detail in FIG. 3 and merely indicated in FIG. 2 .
  • the handling device 50 transmits the data read by the reading device 54 via the handling device control line 13 to the control device 10 , which evaluates said data and, for example, transmits it to the object carrier printer 20 via the object carrier printer control line 11 for the purpose of corresponding printing of the object carrier 25 .
  • Additional information relating to the further treatment can be stored individually in the control device 10 in relation to each of the samples stored in the magazine 60 . This information can contain the desired number of thin sections, the section thickness, the section plane and the cutting speed, and in this way can be used for the further optimal control of the microtome 30 . After the thin sections have been created as described in relation to FIG. 1 , the cartridge 40 is returned from the sample holder 34 into the associated partition 61 of the magazine 60 .
  • the next cartridge to be microtomed is brought into the gripping position, picked up by the gripper 51 and inserted into the sample holder 34 as described above by the displacer 52 in order to produce a thin section.
  • Each of the steps described here can be implemented by individually controllable drive means.
  • the upper or lower side of the magazine 60 is provided with guide channels 64 arranged at right angles to the direction of the stepping movement.
  • a pin bar which is not specifically illustrated, is mounted such that it can pivot, the pin of which engages in the guide channels 64 of the magazine 60 and, guided along an inclined control profile, not further illustrated, ensures a stepping movement of the magazine 60 in the direction of the magazine guides 63 .
  • the guide channels 64 themselves can also be arranged obliquely with respect to the direction of the stepping movement. Then, the translational movement of the displacer 52 and gripper 51 can be used directly to produce the stepping movement.
  • the magazine 60 illustrated in FIG. 2 has partitions 61 aligned obliquely with respect to the magazine guide 63 , so that the cartridges and therefore also the embedded samples are aligned with their section plane parallel to the plane of the sample holder 34 .
  • the angle of inclination of the partitions 61 in the magazine 60 therefore preferably coincides with the angle at which the cutting movement on the microtome 30 is carried out.
  • the partitions 61 can be arranged vertically in the magazine 60 . It is advantageous in this case that the magazine 60 can then hold more cartridges.
  • FIG. 3 An empty cartridge 41 with an empty identification area 43 is illustrated in FIG. 3 .
  • the cartridge 41 has apertures 44 , illustrated as square, in its housing for the improved fixing of the embedding material for the samples.
  • an individual cartridge code 45 is applied by the operator in the identification area 43 .
  • FIG. 4 shows a cartridge 40 with sample 42 embedded and an individual cartridge code 45 applied in the identification area 43 .
  • the individual cartridge code 45 normally contains only data which permits the sample to be assigned to a patient and to an examination or removable time, because of the restricted space in the identification area 43 of the cartridge 40 .
  • code identifiers with a high information storage density are used, all the information data relating to the sample 42 and additional information data relating to the creation of the thin sections can be stored on the cartridge itself. The effort for information processing in the control device 10 can be reduced in this way, since the cartridge 40 itself already contains all the relevant information in its individual cartridge code 45 .
  • the microtome 30 Since a large number of parameters influence the quality of the thin sections produced by the microtome 30 , it is advantageous to deposit additional information and findings about the condition of the sample 42 embedded in the cartridge 40 in a data base belonging to the control device 10 or in the individual cartridge code 45 . For instance, if it is a soft sample, the preferred cutting speed should be chosen differently than in the case of a hard sample. The size of the sample influences the size of the cutting window.
  • findings about these parameters can already be assigned during the sample processing to each individual cartridge by experienced personnel and already have an advantageous influence in advance on the quality of the thin sections subsequently produced.
  • each cartridge in the magazine 60 and the individual cartridge code 45 associated with one another can be stored in a data base belonging to the control device 10 .
  • this information can also be stored directly there.
  • bar codes known per se two-dimensional dot(bar)codes, magnetic storage media or (film) microchips which can be programmed and read by radio can be used.
  • the magazine 60 together with the cartridges stored there can also be cooled down in the refrigerated/insulated housing 55 mentioned in the description relating to FIG. 2 before the production of a section.
  • the control device 10 ensures that the sample 42 is brought to the optimum cutting temperature. Given an appropriate configuration as a refrigerated housing 55 , even the freezing temperature of the sample 42 otherwise used only in the case of what are known as cryostat microtomes can also be achieved.
  • cryostat microtomes have the disadvantage that the entire microtome is located in a refrigerated chamber, which results in an increased power consumption and makes the design, handling and cleaning of the microtomes more difficult.
  • the microtomes according to the invention there is the advantage that the operating personnel can operate in an accustomed manner, as in the case of a conventional microtome, and it is nevertheless possible to process samples which can otherwise only be microtomed in the frozen state.
  • the ideal cutting temperature can on the one hand be stored in a data base which belongs to the control device 10 such that it can be assigned to the individual cartridges or magazines, or stored in the magazine code 62 itself.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
US11/103,596 2004-04-21 2005-04-12 Microtome for producing thin sections Abandoned US20050235542A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE202004006265.8 2004-04-21
DE202004006265U DE202004006265U1 (de) 2004-04-21 2004-04-21 Mikrotem zur Erzeugung von Dünnschnitten

Publications (1)

Publication Number Publication Date
US20050235542A1 true US20050235542A1 (en) 2005-10-27

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US11/103,596 Abandoned US20050235542A1 (en) 2004-04-21 2005-04-12 Microtome for producing thin sections

Country Status (2)

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US (1) US20050235542A1 (de)
DE (1) DE202004006265U1 (de)

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US20070120304A1 (en) * 2004-01-22 2007-05-31 Bui Xuan S Multi-axis workpiece chuck
US20070141711A1 (en) * 2005-12-19 2007-06-21 Randy Stephens Automated lean methods in anatomical pathology
US20070172100A1 (en) * 2006-01-20 2007-07-26 Sakura Finetek U.S.A., Inc. Automated system of processing biological specimens and method
US20070180965A1 (en) * 2006-01-25 2007-08-09 Tetsumasa Ito Automatic slicing apparatus
US20070204740A1 (en) * 2005-12-28 2007-09-06 Tatsuya Miyatani Automatic instrument for fabricating prepared slide of tissue section and automatic prepared slide fabricating method
US7400983B2 (en) 2002-12-20 2008-07-15 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US20090146335A1 (en) * 2007-12-11 2009-06-11 Leica Biosystems Nussloch Gmbh Cassette Changing Device
US20090148264A1 (en) * 2007-12-10 2009-06-11 Leica Biosystems Nussloch Gmbh Object block magazine
US20100030364A1 (en) * 2006-02-13 2010-02-04 Koji Fujimoto Automatic Thin-Section Slides Manufacturing System and Automated Thin-Section Slides Manufacturing Method
GB2463133A (en) * 2008-09-09 2010-03-10 Leica Biosystems Nussloch Gmbh Microtome with cassette changing apparatus
US20100083777A1 (en) * 2008-10-06 2010-04-08 Leica Biosystems Nussloch Gmbh Apparatus and Method for Storing at Least One Specimen Slide and at Least One Cassette
US20100101385A1 (en) * 2008-10-23 2010-04-29 Leica Biosystems Nussloch Gmbh Method and apparatus for operating a microtome
EP1985985A4 (de) * 2006-02-13 2010-05-19 Seiko Instr Inc Automatisches gerät zur herstellung von schnittstückproben und automatisches verfahren zur herstellung von schnittstückproben
US20110015740A1 (en) * 2009-07-14 2011-01-20 Biomet Manufacturing Corp. Pyrocarbon Orthopedic Implant
GB2462730B (en) * 2008-09-16 2011-03-02 Leica Biosystems Nussloch Gmbh Microtome for producing sections of specimens
AU2012202649B2 (en) * 2005-12-19 2012-11-15 Ventana Medical Systems, Inc. Automated lean methods in anatomical pathology
US8512651B2 (en) 2008-10-06 2013-08-20 Leica Biosystems Nusslock GmbH Apparatus and method for identifying at least one specimen slide
US8645167B2 (en) 2008-02-29 2014-02-04 Dakocytomation Denmark A/S Systems and methods for tracking and providing workflow information
US8676509B2 (en) 2001-11-13 2014-03-18 Dako Denmark A/S System for tracking biological samples
EP2302350A3 (de) * 2009-09-25 2014-05-21 Thermo Shandon Ltd Vorrichtung zur Einbettung von Gewebeproben
US8869666B2 (en) 2011-03-24 2014-10-28 Sakura Finetek U.S.A., Inc. Microtome with surface orientation sensor to sense orientation of surface of sample
US9032854B2 (en) 2011-12-21 2015-05-19 Sakura Finetek U.S.A., Inc. Reciprocating microtome drive system
JP2015145795A (ja) * 2014-01-31 2015-08-13 株式会社サニー・シーリング 検体情報管理システム
WO2016016795A1 (en) 2014-08-01 2016-02-04 Diapath S.P.A. Microtome and method for roughing and sectioning specimens of biological material
EP2933626A4 (de) * 2012-12-11 2016-08-03 Sakura Finetek Japan Co Ltd Automatische thin-slicing-vorrichtung, parametererzeugungsvorrichtung, automatisches thin-slicing-verfahren und programm
US9702792B2 (en) 2013-07-16 2017-07-11 Leica Biosystems Nussloch Gmbh Transport device for samples in a microtome
US9799113B2 (en) 2015-05-21 2017-10-24 Invicro Llc Multi-spectral three dimensional imaging system and method
US10571368B2 (en) 2015-06-30 2020-02-25 Clarapath, Inc. Automated system and method for advancing tape to transport cut tissue sections
US10724929B2 (en) 2016-05-13 2020-07-28 Clarapath, Inc. Automated tissue sectioning and storage system
WO2021168457A1 (en) 2020-02-22 2021-08-26 Clarapath, Inc. Facing and quality control in microtomy
CN114144312A (zh) * 2019-07-18 2022-03-04 莱卡生物系统努斯洛赫有限责任公司 用于打印组织学实验室消耗品的打印机
US11630035B2 (en) 2015-06-30 2023-04-18 Clarapath, Inc. Method, system, and device for automating transfer of tape to microtome sections
US11959835B2 (en) 2020-10-23 2024-04-16 Clarapath, Inc. Preliminary diagnoses of cut tissue sections
US12498298B2 (en) 2021-12-20 2025-12-16 Clarapath, Inc. Automated tissue section system with cut quality prediction

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DE102005012745B3 (de) * 2005-03-19 2006-08-17 Microm International Gmbh Vorrichtung zur Handhabung mikrotomierter Gewebeproben
DE102014200448A1 (de) * 2014-01-13 2015-07-16 Leica Microsystems Cms Gmbh Verfahren zum Analysieren einer Probe mit einem Mikroskop
LU101311B1 (de) * 2019-07-18 2021-01-20 Leica Biosystems Nussloch Gmbh Drucker zum Bedrucken von Histologielabor-Verbrauchsartikeln
CN114311057B (zh) * 2021-12-27 2022-12-23 中国科学技术大学 一种超大样品振动切片及收集自动化装置

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US8676509B2 (en) 2001-11-13 2014-03-18 Dako Denmark A/S System for tracking biological samples
US7400983B2 (en) 2002-12-20 2008-07-15 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8386195B2 (en) 2002-12-20 2013-02-26 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US7937228B2 (en) 2002-12-20 2011-05-03 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US8788217B2 (en) 2002-12-20 2014-07-22 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US9229016B2 (en) 2002-12-20 2016-01-05 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
US10156580B2 (en) 2002-12-20 2018-12-18 Dako Denmark A/S Information notification sample processing system and methods of biological slide processing
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JP2009520186A (ja) * 2005-12-19 2009-05-21 ヴェンタナ メディカル システムズ， インコーポレイテッド 解剖病理学における自動リーンメソッド
US20070141711A1 (en) * 2005-12-19 2007-06-21 Randy Stephens Automated lean methods in anatomical pathology
JP2012058261A (ja) * 2005-12-19 2012-03-22 Ventana Medical System Inc 解剖病理学における自動リーンメソッド
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AU2012202649B2 (en) * 2005-12-19 2012-11-15 Ventana Medical Systems, Inc. Automated lean methods in anatomical pathology
US10228311B2 (en) 2005-12-19 2019-03-12 Ventana Medical Systems, Inc Automated lean methods in anatomical pathology
US20070204740A1 (en) * 2005-12-28 2007-09-06 Tatsuya Miyatani Automatic instrument for fabricating prepared slide of tissue section and automatic prepared slide fabricating method
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US8074547B2 (en) * 2006-01-25 2011-12-13 Seiko Instruments Inc. Automatic slicing apparatus
US20070180965A1 (en) * 2006-01-25 2007-08-09 Tetsumasa Ito Automatic slicing apparatus
EP1985984A4 (de) * 2006-02-13 2010-06-23 Seiko Instr Inc Automatisches gerät zur herstellung von scheibenförmigen proben, und automatisches verfahren zur herstellung von scheibenförmigen proben
EP1985985A4 (de) * 2006-02-13 2010-05-19 Seiko Instr Inc Automatisches gerät zur herstellung von schnittstückproben und automatisches verfahren zur herstellung von schnittstückproben
US20100229702A1 (en) * 2006-02-13 2010-09-16 Koji Fujimoto Automatic Prepared Slide Fabricating Apparatus and Automatic Prepared Slide Fabricating Method
US20100030364A1 (en) * 2006-02-13 2010-02-04 Koji Fujimoto Automatic Thin-Section Slides Manufacturing System and Automated Thin-Section Slides Manufacturing Method
US7966091B2 (en) 2006-02-13 2011-06-21 Seiko Instruments Inc. Automatic thin-section slides manufacturing system and method
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