US20040102678A1 - Bag for at least partially enveloping a heart - Google Patents
Bag for at least partially enveloping a heart Download PDFInfo
- Publication number
- US20040102678A1 US20040102678A1 US10/703,709 US70370903A US2004102678A1 US 20040102678 A1 US20040102678 A1 US 20040102678A1 US 70370903 A US70370903 A US 70370903A US 2004102678 A1 US2004102678 A1 US 2004102678A1
- Authority
- US
- United States
- Prior art keywords
- pouch
- heart
- threads
- knit
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000006260 foam Substances 0.000 claims description 12
- 239000004744 fabric Substances 0.000 claims description 11
- 239000000314 lubricant Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 8
- 229920001169 thermoplastic Polymers 0.000 claims description 6
- 239000004416 thermosoftening plastic Substances 0.000 claims description 6
- 230000003205 diastolic effect Effects 0.000 claims description 5
- 239000013013 elastic material Substances 0.000 claims description 5
- 239000011148 porous material Substances 0.000 claims description 5
- 238000007493 shaping process Methods 0.000 claims description 5
- 210000003516 pericardium Anatomy 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 238000005452 bending Methods 0.000 claims description 3
- 239000012620 biological material Substances 0.000 claims description 3
- 230000007423 decrease Effects 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- 241000283690 Bos taurus Species 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 abstract description 5
- 230000010339 dilation Effects 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 208000035473 Communicable disease Diseases 0.000 abstract description 2
- 208000036142 Viral infection Diseases 0.000 abstract description 2
- 230000001363 autoimmune Effects 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 230000009385 viral infection Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 206010000060 Abdominal distension Diseases 0.000 description 2
- 210000005242 cardiac chamber Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000003365 myofibril Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 208000006029 Cardiomegaly Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 229920002323 Silicone foam Polymers 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000013514 silicone foam Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2478—Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
- A61F2/2481—Devices outside the heart wall, e.g. bags, strips or bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
Definitions
- the invention relates to a bag, hereafter called pouch, with which to at least partly enclose a heart.
- German patent document U1 295 17 393 discloses a pouch defined in the preamble of claim 1 ; this pouch however is inelastic and serves to prevent myocardial dilation by the end-diastolic pressure. While this known pouch does prevent cardiac wall distention, it delivers this effect impulsively once the heart volume equals the volume enclosed by the pouch. This impulsive effect adversely affects the heart. Moreover pleats may form in the pouch when the heart volume is less than that subtended by the size of the pouch.
- the objective of the invention is to create a pouch with which to at least partly enclose a heart and opposing heart distention without thereby degrading heart function.
- the basic concept of the invention is to absorb in part the strains in the wall of the hollow body foremost constituted by the left heart chamber and to relieve thereby the myofibrils. This general effect alone already may prevent enlarging the heart volume beyond a critical value. Accordingly the pouch of the invention offers a support role.
- the elasticity function of the invention may be implemented in a number of ways.
- a very simple implementation calls for the pouch always exerting the same force on the heart regardless of the pouch's elongation, as a result of which the heart, regardless of its volume, shall always be relieved at substantially the same strain.
- the pouch wall is elastic, whereby the stress it exerts and hence the relief of the heart increases with volume.
- the characteristics of elongation may be altered depending on the desired relief.
- the pouch wall elasticity decreases with increasing stretching in order to account for the specific strain in the heart wall.
- said stretching shall be bounded by a limit value at which the heart no longer can enlarge.
- this limit value cannot be reached impulsively, but because of the elasticity of the pouch of the invention, can be reached only gradually, as a result of which impulsive pouch actions are precluded.
- the pouch limit value appropriately shall be at a pouch volume corresponding to the heart volume at maximum diastolic filling. On the whole, therefore, the kind of elasticity and the shape of the stretching curve of the pouch allows determining and adapting the myofibril relief implemented by this pouch.
- the pouch To mount the pouch in place, it can be thorascopically opened and then be drawn over the heart muscle. This motion illustratively proceeds to the anulus fibrosus, that is, the valve plane, where the pouch shall be fixed in place.
- the volume of the pouch in its unstretched state is less than the volume of the heart in the stage of minimum filling. As a result, the pouch shall reliably rest against the heart in all stretching phases.
- the pouch wall is elastic and the stretching is bounded by a limit value
- the pouch shall be made of an elastic and of an inelastic material.
- the elastic material determines the stretching function
- the inelastic material determines the stretching limit value.
- the elastic material is made of a threaded sheet or fabric or knit into which are integrated threads made of a substantially inelastic material. The substantially spatially inelastic threads appropriately are longitudinally displaceable in the sheet or fabric or knit.
- the substantially inelastic threads be guided segment-wise out of the pouch and in this manner are adapted at maximum diastolic filling by being segment-wise knotted in length and volume to the shape and/or volume of the pouch.
- the substantially inelastic threads run appropriately from the edge of the pouch aperture to a substantially opposite tip of the pouch. The threads then can be guided out of the pouch in the zone of its tip.
- the pouch appropriately consists of a fabric or knit made of inelastic threads while however allowing bending and being crimped transversely to their longitudinal direction. This kind of shaping allows determining the stretching function and the limit value.
- the pouch wall is a thermoplastic allowing simple shaping of the pouch and adapting it to the shape of the heart, or it may be made of a biological material, denatured bovine pericardium being especially suitable.
- the wall of the pouch of the invention appropriately shall be a netting.
- netting appropriately may be made of an open-pore foam, for instance silicone foam.
- a foam assures highly uniform and gentle application of pressure to the heart muscle.
- a foam is able to absorb a lubricant, for instance a serous liquid, thus providing good slippage between pouch and pericardium.
- the lubricant is biological and genetically engineered, hyaluronic acid being especially suitable.
- the wall of the pouch of the invention is a netting, then such may be formed as a perforated sheet. Such a sheet is able to transmit the pouch pressure through a large surface to the heart.
- the wall of the pouch of the invention also may be a fabric or a knit. In this manner the pouch's stretching behavior can be matched to any particulars within wide limits.
- pouch wall netting being constituted by a sheet, fabric or knit, appropriately an additional coating of open-pore foam shall be provided to assure uniform force transmission and also holding any lubricants.
- the pouch be composed of two kinds of plastic threads or fibers, one kind of higher, and preferably much higher shaping temperature than the other, one kind being elastic and the other kind relatively less, preferably much less elastic than the other.
- thermoplastically shape the pouch at a temperature at which the less elastic or inelastic material remains permanently shaped at a given shaping temperature, though not the more elastic material.
- the less elastic or inelastic material in this manner determines the maximum pouch stretching whereas the elastic material, which shall return to its initial shape, applies constricting forces on the heart, below the shape determined by the less or inelastic material.
- the plastic used in manufacturing the pouch is thermoplastic. This feature offers the advantage that not only can the pouch be prefinished in simple manner into a given shape, but also that the pouch can be shaped during surgery, or its shape may be altered during surgery, in order to adapt the dimensions so found to the parts of the heart to be enclosed.
- the foam is made of silicone.
- the objective of the invention furthermore is to propose a method for manufacturing a pouch as defined in claim 1 .
- This problem is resolved by making a mold in the shape of the heart part to be enclosed and in that a gas- and/or liquid-permeable sheet or a netting of knit consisting of a thermoplastic is pulled over the mold while heated.
- the structure of the mold appropriately is entailed or determined by imaging the shape of the heart to be enclosed and in that the mold is produced from this image.
- the image can be produced in arbitrary manner, for instance by x-rays or computer tomography.
- FIG. 1 shows a first embodiment of the invention
- FIG. 2 is a second embodiment of the invention.
- FIG. 3 is a third embodiment of the invention.
- the drawing schematically shows a heart 1 partly enclosed by a pouch 2 of which the wall consists of a netting 3 .
- the pouch 2 reaches as far as into the zone of the anulus fibrosus, that is as far as the valve plane, where it is affixed (omitted from the drawing) to the heart muscle along a selvage 4 .
- the netting 3 consists of elastic threads. In the unstretched state, the volume of the pouch 2 is less than the volume of the heart 1 in the stage of minimum filling. As a result, the netting shall rest against the heart 1 in all stretching stages.
- FIG. 2 shows a second embodiment of the invention which is a variant of that of FIG. 1. Identical or corresponding components are denoted by identical references. The difference is that threads 5 converge from the selvage 4 into a central point 6 , whereas threads 7 run substantially circumferentially. Where they cross at points 8 , the threads 5 and 7 are connected to each other, either by being fused, bonded or by dipping the entire pouch 2 into a body of material, for instance foam which shall subsequently solidify.
- FIG. 3 shows an embodiment of a pouch 9 consisting of a knit of threads 10 running from a selvage 11 to a central point 12 where they are bundled away at their ends 13 which, following application of the pouch 9 , then can be tensioned or be knotted to one another in order to match thereby the pouch 9 to the shape and volume of the heart 1 .
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
A pouch to at least partly enclose a heart (1), the wall of the pouch (2) being elastic. The purpose of the pouch is to enclose at least part of a heart (1) and to oppose excessive dilation of the heart (1) that might be due to infectious disease of the heart muscle, for instance a viral infection or an autoimmune process. In many cases the use of such a pouch (2) may circumvent the need for a heart transplant.
Description
- This application is a continuation of application no. PCT/EP98/03619, filed Jun. 16, 1998, which application claims the priority of German application no. 197 26 389.5, filed Jun. 21, 1997, and each of which is incorporated herein by reference.
- The invention relates to a bag, hereafter called pouch, with which to at least partly enclose a heart.
- Infectious disease of the heart muscle both by viral infection and by autoimmune processes may lead to enlarged heart volume. If such an enlargement exceeds a critical value, the result will be progressive heart dilation which can be explained by Laplace's law. As the volume subtended by the left heart chamber increases, the stresses in the walls of this cavity will increase. Consequently the muscle fibrils are overloaded and their ideal range of elongation is exceeded. When this excessive elongation takes place, there is, as a rule, a residual volume in the heart. Then the muscle fibrils must operate against a primarily high wall strain, and are further extended thereby. A vicious cycle arises, leading to increasing distension of the heart and consequent heart insufficiency.
- It is basically feasible to treat such a development in its early stages by medicinally lowering the initial load by ACE inhibitors, however such treatment is not always successful. Moreover, on account of initially slight clinical effects, the status will be noticed many times only when a critical point already has been passed. In that case only a heart transplant can be resorted to.
- The German patent document U1 295 17 393 discloses a pouch defined in the preamble of
claim 1; this pouch however is inelastic and serves to prevent myocardial dilation by the end-diastolic pressure. While this known pouch does prevent cardiac wall distention, it delivers this effect impulsively once the heart volume equals the volume enclosed by the pouch. This impulsive effect adversely affects the heart. Moreover pleats may form in the pouch when the heart volume is less than that subtended by the size of the pouch. - The objective of the invention is to create a pouch with which to at least partly enclose a heart and opposing heart distention without thereby degrading heart function.
- The problem basic to the invention is resolved by the disclosure of the characterizing part of
claim 1. - The basic concept of the invention is to absorb in part the strains in the wall of the hollow body foremost constituted by the left heart chamber and to relieve thereby the myofibrils. This general effect alone already may prevent enlarging the heart volume beyond a critical value. Accordingly the pouch of the invention offers a support role.
- The elasticity function of the invention may be implemented in a number of ways. A very simple implementation calls for the pouch always exerting the same force on the heart regardless of the pouch's elongation, as a result of which the heart, regardless of its volume, shall always be relieved at substantially the same strain. In another appropriate embodiment of the invention, the pouch wall is elastic, whereby the stress it exerts and hence the relief of the heart increases with volume. The characteristics of elongation may be altered depending on the desired relief. Appropriately for instance the pouch wall elasticity decreases with increasing stretching in order to account for the specific strain in the heart wall. Advantageously too, said stretching shall be bounded by a limit value at which the heart no longer can enlarge. Contrary to the known pouch, this limit value cannot be reached impulsively, but because of the elasticity of the pouch of the invention, can be reached only gradually, as a result of which impulsive pouch actions are precluded. The pouch limit value appropriately shall be at a pouch volume corresponding to the heart volume at maximum diastolic filling. On the whole, therefore, the kind of elasticity and the shape of the stretching curve of the pouch allows determining and adapting the myofibril relief implemented by this pouch.
- To mount the pouch in place, it can be thorascopically opened and then be drawn over the heart muscle. This motion illustratively proceeds to the anulus fibrosus, that is, the valve plane, where the pouch shall be fixed in place.
- In a further embodiment of the invention, the volume of the pouch in its unstretched state is less than the volume of the heart in the stage of minimum filling. As a result, the pouch shall reliably rest against the heart in all stretching phases.
- If, as in one embodiment of the invention, the pouch wall is elastic and the stretching is bounded by a limit value, then advantageously the pouch shall be made of an elastic and of an inelastic material. In this case the elastic material determines the stretching function, whereas the inelastic material determines the stretching limit value. Appropriately in practice, the elastic material is made of a threaded sheet or fabric or knit into which are integrated threads made of a substantially inelastic material. The substantially spatially inelastic threads appropriately are longitudinally displaceable in the sheet or fabric or knit.
- In this embodiment it is especially-advantageous that the substantially inelastic threads be guided segment-wise out of the pouch and in this manner are adapted at maximum diastolic filling by being segment-wise knotted in length and volume to the shape and/or volume of the pouch. In this process the substantially inelastic threads run appropriately from the edge of the pouch aperture to a substantially opposite tip of the pouch. The threads then can be guided out of the pouch in the zone of its tip.
- As regards the embodiment wherein the pouch dilation is subject to a limit value, the pouch appropriately consists of a fabric or knit made of inelastic threads while however allowing bending and being crimped transversely to their longitudinal direction. This kind of shaping allows determining the stretching function and the limit value.
- Appropriately the pouch wall is a thermoplastic allowing simple shaping of the pouch and adapting it to the shape of the heart, or it may be made of a biological material, denatured bovine pericardium being especially suitable.
- To implement permeability to gases, in particular oxygen, and to liquids, the wall of the pouch of the invention appropriately shall be a netting. Such netting appropriately may be made of an open-pore foam, for instance silicone foam. Such a foam assures highly uniform and gentle application of pressure to the heart muscle. Moreover such a foam is able to absorb a lubricant, for instance a serous liquid, thus providing good slippage between pouch and pericardium. Appropriately the lubricant is biological and genetically engineered, hyaluronic acid being especially suitable. By introducing a lubricant beforehand into the foam, good slipping properties are provided from the beginning and as a result primary, self-reinforcing irritation of the pericardium shall be avoided.
- If the wall of the pouch of the invention is a netting, then such may be formed as a perforated sheet. Such a sheet is able to transmit the pouch pressure through a large surface to the heart.
- The wall of the pouch of the invention also may be a fabric or a knit. In this manner the pouch's stretching behavior can be matched to any particulars within wide limits.
- Regardless of the pouch wall netting being constituted by a sheet, fabric or knit, appropriately an additional coating of open-pore foam shall be provided to assure uniform force transmission and also holding any lubricants.
- If the elasticity of the pouch wall decreases as stretching increases, or if there is a limit value on stretching, then a special embodiment of the invention provides that the pouch be composed of two kinds of plastic threads or fibers, one kind of higher, and preferably much higher shaping temperature than the other, one kind being elastic and the other kind relatively less, preferably much less elastic than the other. By using such differing fibers, it is possible to thermoplastically shape the pouch at a temperature at which the less elastic or inelastic material remains permanently shaped at a given shaping temperature, though not the more elastic material. The less elastic or inelastic material in this manner determines the maximum pouch stretching whereas the elastic material, which shall return to its initial shape, applies constricting forces on the heart, below the shape determined by the less or inelastic material.
- In another embodiment of the invention, the plastic used in manufacturing the pouch is thermoplastic. This feature offers the advantage that not only can the pouch be prefinished in simple manner into a given shape, but also that the pouch can be shaped during surgery, or its shape may be altered during surgery, in order to adapt the dimensions so found to the parts of the heart to be enclosed.
- In a further embodiment of the invention the foam is made of silicone.
- The objective of the invention furthermore is to propose a method for manufacturing a pouch as defined in
claim 1. This problem is resolved by making a mold in the shape of the heart part to be enclosed and in that a gas- and/or liquid-permeable sheet or a netting of knit consisting of a thermoplastic is pulled over the mold while heated. - The structure of the mold appropriately is entailed or determined by imaging the shape of the heart to be enclosed and in that the mold is produced from this image. The image can be produced in arbitrary manner, for instance by x-rays or computer tomography.
- The invention is elucidated further in relation to the drawings.
- FIG. 1 shows a first embodiment of the invention,
- FIG. 2 is a second embodiment of the invention, and
- FIG. 3 is a third embodiment of the invention.
- The drawing schematically shows a
heart 1 partly enclosed by apouch 2 of which the wall consists of anetting 3. Thepouch 2 reaches as far as into the zone of the anulus fibrosus, that is as far as the valve plane, where it is affixed (omitted from the drawing) to the heart muscle along a selvage 4. Thenetting 3 consists of elastic threads. In the unstretched state, the volume of thepouch 2 is less than the volume of theheart 1 in the stage of minimum filling. As a result, the netting shall rest against theheart 1 in all stretching stages. - FIG. 2 shows a second embodiment of the invention which is a variant of that of FIG. 1. Identical or corresponding components are denoted by identical references. The difference is that
threads 5 converge from the selvage 4 into a central point 6, whereasthreads 7 run substantially circumferentially. Where they cross atpoints 8, the 5 and 7 are connected to each other, either by being fused, bonded or by dipping thethreads entire pouch 2 into a body of material, for instance foam which shall subsequently solidify. - FIG. 3 shows an embodiment of a
pouch 9 consisting of a knit ofthreads 10 running from aselvage 11 to acentral point 12 where they are bundled away at theirends 13 which, following application of thepouch 9, then can be tensioned or be knotted to one another in order to match thereby thepouch 9 to the shape and volume of theheart 1.
Claims (32)
1. A pouch (2) enclosing at least partly a heart (1) characterized in that the wall of the pouch (2) is elastic.
2. Pouch as claimed in claim 1 , characterized in that the elasticity of the wall of the pouch (2) decreases with increasing stretching.
3. Pouch as claimed in claim 2 , characterized in that the stretching is bounded by a limit value.
4. Pouch as claimed in claim 3 , characterized in that the limit value is set at a pouch volume corresponding to the volume of the heart in the stage of maximum diastolic filling.
5. Pouch as claimed in claim 1 , characterized in that the pouch volume in the stretched condition corresponds at a m maximum to the volume of the heart in the stage of maximum diastolic filling.
6. Pouch as claimed in claim 3 , characterized in that it is composed of elastic and of inelastic material.
7. Pouch as claimed in claim 6 , characterized in that the elastic material consists of a sheet or a fabric or a knit consisting of threads into which are incorporated substantially non-elastic threads.
8. Pouch as claimed in claim 7 , characterized in that the substantially inelastic threads are incorporated into the sheet or the fabric or knit in longitudinally displaceable manner.
9. Pouch as claimed in claim 8 , characterized in that the substantially inelastic threads are guided each in by segment out of the pouch and thus are adjustable in length by means of segment-wise knotting and in that the volume and/or the shape of the pouch can be matched to the volume and/or the shape of the heart at maximum diastolic filling.
10. Pouch as claimed in claim 9 , characterized in that the substantially inelastic threads run from the aperture edge of the pouch to a substantially opposite pouch tip.
11. Pouch as claimed in claim 10 , characterized in that threads issue from the pouch in the vicinity of its tip.
12. Pouch as claimed in claim 3 , characterized in that consists of a sheet, a fabric or a knit comprising crimps, a pleat, accordion geometry or the like.
13. Pouch as claimed in claim 3 , characterized in that it consists of a fabric or knit of inelastic but bending threads crimped transversely to their longitudinal direction, in particular in wavy and/or sig-zag manner.
14. Pouch as claimed in claim 13 , characterized in that the crimps are thermally set.
15. Pouch as claimed in claim 3 , characterized in that the pouch is made of a knit and in that the knit's threads are inelastic but bending.
16. Pouch as claimed in claim 1 , characterized in that the wall of the pouch (2) consists of plastic or a biological material.
17. Pouch as claimed in claim 16 , characterized in that the biological material is bovine pericardium.
18. Pouch as claimed in claim 1 , characterized in that the wall is in the form of a netting (3).
19. Pouch as claimed in claim 18 , characterized in that the netting (3) consists of open-pore foam.
20. Pouch as claimed in claim 18 , characterized in that the netting (3) consists of a perforated sheet.
21. Pouch as claimed in claim 18 , characterized in that the netting (3) consists of a fabric or a knit.
22. Pouch as claimed in claim 21 , characterized in that the sheet or the fabric or knit is coated with open-pore foam.
23. Pouch as claimed in claim 2 , characterized in that the pouch (2) consists of two kinds of thermoplastic threads or fibers, one kind of which is of a higher, preferably substantially higher shaping temperature than the other kind, the one kind being elastic and the other kind being relatively less elastic, preferably substantially less elastic.
24. Pouch as claimed in claim 23 , characterized in that the plastic is a thermoplastic.
25. Pouch as claimed in claim 19 , characterized in that the foam consists of silicone.
26. Pouch as claimed in claim 19 , characterized in that the foam is a lubricant.
27. Pouch as claimed in claim 26 , characterized in that the lubricant is a biological lubricant.
28. Pouch as claimed in claim 26 , characterized in that the lubricant is genetically engineered.
29. Pouch as claimed in claim 28 , characterized in that the genetically engineered lubricant is hyaluronic acid.
30. A method for manufacturing a pouch as claimed in claim 1 , characterized in that a mold in the shape of the article intended to enclose the heart is manufactured and in that a gas- and/or a liquid-permeable sheet or a netting or a knit made of a thermoplastic is pulled over the mold and shaped while heated.
31. Method as claimed in claim 30 , characterized in that the shape of the heart to be enclosed is imaged and in that the mold is made based on that image.
32. Pouch as claimed in claim 1 , characterized in that the wall of the pouch is made of tetrafluoroethylene, in particular of open-pore polytetrafluoroethylne foam
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/703,709 US20040102678A1 (en) | 1997-06-21 | 2003-11-07 | Bag for at least partially enveloping a heart |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19726389.5 | 1997-06-21 | ||
| DE19726389 | 1997-06-21 | ||
| PCT/EP1998/003619 WO1998058598A1 (en) | 1997-06-21 | 1998-06-16 | Bag for at least partially enveloping a heart |
| US09/453,722 US6416459B1 (en) | 1997-06-21 | 1999-12-03 | Bag for at least partially enveloping a heart |
| US10/140,225 US6645139B2 (en) | 1997-06-21 | 2002-05-07 | Bag for at least partially enveloping a heart |
| US10/703,709 US20040102678A1 (en) | 1997-06-21 | 2003-11-07 | Bag for at least partially enveloping a heart |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/140,225 Continuation US6645139B2 (en) | 1997-06-21 | 2002-05-07 | Bag for at least partially enveloping a heart |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20040102678A1 true US20040102678A1 (en) | 2004-05-27 |
Family
ID=7833239
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/453,722 Expired - Fee Related US6416459B1 (en) | 1997-06-21 | 1999-12-03 | Bag for at least partially enveloping a heart |
| US10/140,225 Expired - Fee Related US6645139B2 (en) | 1997-06-21 | 2002-05-07 | Bag for at least partially enveloping a heart |
| US10/703,709 Abandoned US20040102678A1 (en) | 1997-06-21 | 2003-11-07 | Bag for at least partially enveloping a heart |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/453,722 Expired - Fee Related US6416459B1 (en) | 1997-06-21 | 1999-12-03 | Bag for at least partially enveloping a heart |
| US10/140,225 Expired - Fee Related US6645139B2 (en) | 1997-06-21 | 2002-05-07 | Bag for at least partially enveloping a heart |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6416459B1 (en) |
| EP (1) | EP0991373B1 (en) |
| JP (1) | JP2002504841A (en) |
| DE (2) | DE59811956D1 (en) |
| WO (1) | WO1998058598A1 (en) |
Cited By (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020029080A1 (en) * | 1997-12-17 | 2002-03-07 | Myocor, Inc. | Valve to myocardium tension members device and method |
| US20020173694A1 (en) * | 1998-07-29 | 2002-11-21 | Myocor, Inc. | Stress reduction apparatus and method |
| US20060148062A1 (en) * | 2004-10-07 | 2006-07-06 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US20060154357A1 (en) * | 2004-10-07 | 2006-07-13 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US7077862B2 (en) | 2002-01-09 | 2006-07-18 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US20060292544A1 (en) * | 2005-06-28 | 2006-12-28 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US7189199B2 (en) | 1997-01-02 | 2007-03-13 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
| US20070129598A1 (en) * | 2001-09-07 | 2007-06-07 | Raman Jaishanker | Method and apparatus for external stabilization of the heart |
| US7247134B2 (en) | 2002-11-12 | 2007-07-24 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US20070275364A1 (en) * | 2004-10-07 | 2007-11-29 | Waleed Hassanein | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US20080017194A1 (en) * | 2006-04-19 | 2008-01-24 | Transmedics, Inc | Systems and methods for ex vivo organ care |
| US20080021266A1 (en) * | 2006-04-19 | 2008-01-24 | Laham Roger J | Pericardial reinforcement device |
| US20080091057A1 (en) * | 2006-10-11 | 2008-04-17 | Cardiac Pacemakers, Inc. | Method and apparatus for passive left atrial support |
| US20080234768A1 (en) * | 2007-03-20 | 2008-09-25 | Transmedics, Inc | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US20080319256A1 (en) * | 1998-07-29 | 2008-12-25 | Myocor, Inc. | Transventricular implant tools and devices |
| US20090049015A1 (en) * | 2005-10-18 | 2009-02-19 | Justsystems Corporation | Data management device and terminal device |
| US20090197292A1 (en) * | 2008-01-31 | 2009-08-06 | Transmedics, Inc | Systems and methods for ex vivo lung care |
| US7695425B2 (en) | 1997-01-02 | 2010-04-13 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
| US7766812B2 (en) | 2000-10-06 | 2010-08-03 | Edwards Lifesciences Llc | Methods and devices for improving mitral valve function |
| US7883539B2 (en) | 1997-01-02 | 2011-02-08 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
| US8579798B2 (en) | 1998-09-21 | 2013-11-12 | Edwards Lifesciences, Llc | External cardiac stress reduction method |
| US9756849B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US10076112B2 (en) | 2014-06-02 | 2018-09-18 | Transmedic, Inc. | Ex vivo organ care system |
| US10194655B2 (en) | 2015-09-09 | 2019-02-05 | Transmedics, Inc. | Aortic cannula for ex vivo organ care system |
| US11856944B2 (en) | 2011-04-14 | 2024-01-02 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
| US11963526B2 (en) | 2014-12-12 | 2024-04-23 | Transmedics, Inc. | Apparatus and method for organ perfusion |
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US12127554B2 (en) | 2016-05-30 | 2024-10-29 | Transmedics, Inc. | Apparatus and method for ex vivo lung ventilation with a varying exterior pressure |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6123662A (en) | 1998-07-13 | 2000-09-26 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
| US5702343A (en) | 1996-10-02 | 1997-12-30 | Acorn Medical, Inc. | Cardiac reinforcement device |
| US20030045771A1 (en) * | 1997-01-02 | 2003-03-06 | Schweich Cyril J. | Heart wall tension reduction devices and methods |
| DE59811956D1 (en) * | 1997-06-21 | 2004-10-21 | Acorn Cardiovascular Inc | BAG FOR AT LEAST PARTIAL ENCLOSURE OF A HEART |
| US6110100A (en) * | 1998-04-22 | 2000-08-29 | Scimed Life Systems, Inc. | System for stress relieving the heart muscle and for controlling heart function |
| AU745832B2 (en) * | 1998-07-13 | 2002-04-11 | Acorn Cardiovascular, Inc. | Cardiac disease treatment device and method |
| US6085754A (en) * | 1998-07-13 | 2000-07-11 | Acorn Cardiovascular, Inc. | Cardiac disease treatment method |
| US6587734B2 (en) | 1998-11-04 | 2003-07-01 | Acorn Cardiovascular, Inc. | Cardio therapeutic heart sack |
| US6169922B1 (en) | 1998-11-18 | 2001-01-02 | Acorn Cardiovascular, Inc. | Defibrillating cardiac jacket with interwoven electrode grids |
| US6230714B1 (en) | 1998-11-18 | 2001-05-15 | Acorn Cardiovascular, Inc. | Cardiac constraint with prior venus occlusion methods |
| AU2506800A (en) | 1999-01-15 | 2000-08-01 | Align Technology, Inc. | System and method for producing tooth movement |
| US6155972A (en) * | 1999-02-02 | 2000-12-05 | Acorn Cardiovascular, Inc. | Cardiac constraint jacket construction |
| US6241654B1 (en) | 1999-07-07 | 2001-06-05 | Acorn Cardiovasculr, Inc. | Cardiac reinforcement devices and methods |
| US6174279B1 (en) | 1999-09-21 | 2001-01-16 | Acorn Cardiovascular, Inc. | Cardiac constraint with tension indicator |
| US6193648B1 (en) | 1999-09-21 | 2001-02-27 | Acorn Cardiovascular, Inc. | Cardiac constraint with draw string tensioning |
| US6179791B1 (en) | 1999-09-21 | 2001-01-30 | Acorn Cardiovascular, Inc. | Device for heart measurement |
| US6702732B1 (en) | 1999-12-22 | 2004-03-09 | Paracor Surgical, Inc. | Expandable cardiac harness for treating congestive heart failure |
| US6293906B1 (en) | 2000-01-14 | 2001-09-25 | Acorn Cardiovascular, Inc. | Delivery of cardiac constraint jacket |
| CA2402504A1 (en) | 2000-03-10 | 2001-09-20 | Paracor Surgical, Inc. | Expandable cardiac harness for treating congestive heart failure |
| US6537198B1 (en) | 2000-03-21 | 2003-03-25 | Myocor, Inc. | Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly |
| US6425856B1 (en) | 2000-05-10 | 2002-07-30 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
| US6902522B1 (en) | 2000-06-12 | 2005-06-07 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
| US6730016B1 (en) | 2000-06-12 | 2004-05-04 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
| US6482146B1 (en) * | 2000-06-13 | 2002-11-19 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
| US6951534B2 (en) * | 2000-06-13 | 2005-10-04 | Acorn Cardiovascular, Inc. | Cardiac support device |
| US6572533B1 (en) | 2000-08-17 | 2003-06-03 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
| US6592515B2 (en) | 2000-09-07 | 2003-07-15 | Ams Research Corporation | Implantable article and method |
| US7025063B2 (en) | 2000-09-07 | 2006-04-11 | Ams Research Corporation | Coated sling material |
| US6887192B1 (en) | 2000-09-08 | 2005-05-03 | Converge Medical, Inc. | Heart support to prevent ventricular remodeling |
| US6564094B2 (en) | 2000-12-22 | 2003-05-13 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
| US6575921B2 (en) | 2001-02-09 | 2003-06-10 | Acorn Cardiovascular, Inc. | Device for heart measurement |
| US6923646B2 (en) * | 2001-04-18 | 2005-08-02 | Air Techniques, Inc. | Process and apparatus for treating an exhaust stream from a dental operatory |
| US20040064014A1 (en) * | 2001-05-31 | 2004-04-01 | Melvin David B. | Devices and methods for assisting natural heart function |
| AU2002335745A1 (en) | 2001-09-10 | 2003-03-24 | Paracor Medical, Inc. | Cardiac harness |
| US7060023B2 (en) * | 2001-09-25 | 2006-06-13 | The Foundry Inc. | Pericardium reinforcing devices and methods of using them |
| CA2460307A1 (en) | 2001-10-31 | 2003-05-08 | Paracor Medical, Inc. | Heart failure treatment device |
| US7174896B1 (en) | 2002-01-07 | 2007-02-13 | Paracor Medical, Inc. | Method and apparatus for supporting a heart |
| US7022063B2 (en) | 2002-01-07 | 2006-04-04 | Paracor Medical, Inc. | Cardiac harness |
| US20030229260A1 (en) * | 2002-06-05 | 2003-12-11 | Acorn Cardiovascular, Inc. | Cardiac support device with tension indicator |
| US20030229261A1 (en) * | 2002-06-06 | 2003-12-11 | Acorn Cardiovascular, Inc. | Cardiac support devices and methods of producing same |
| US6682475B2 (en) | 2002-06-11 | 2004-01-27 | Acorn Cardiovascular, Inc. | Tension indicator for cardiac support device and method therefore |
| US7814055B2 (en) * | 2002-08-28 | 2010-10-12 | Apple Inc. | Method of managing a calendar and a computer system for implementing that method |
| WO2004021927A2 (en) | 2002-09-05 | 2004-03-18 | Paracor Medical, Inc. | Cardiac harness |
| US7736299B2 (en) | 2002-11-15 | 2010-06-15 | Paracor Medical, Inc. | Introducer for a cardiac harness delivery |
| US7229405B2 (en) | 2002-11-15 | 2007-06-12 | Paracor Medical, Inc. | Cardiac harness delivery device and method of use |
| WO2004045456A2 (en) | 2002-11-15 | 2004-06-03 | Paracor Medical, Inc. | Cardiac harness delivery device |
| EP1585437B1 (en) * | 2003-01-24 | 2014-01-01 | Applied Medical Resources Corporation | Internal tissue retractor |
| US7883500B2 (en) * | 2003-03-26 | 2011-02-08 | G&L Consulting, Llc | Method and system to treat and prevent myocardial infarct expansion |
| US7341584B1 (en) | 2003-05-30 | 2008-03-11 | Thomas David Starkey | Device and method to limit filling of the heart |
| US20050008997A1 (en) * | 2003-07-08 | 2005-01-13 | Mayo Foundation For Medical Education And Research | Portable endoscopic training and research device and methods of use |
| WO2005007032A2 (en) | 2003-07-10 | 2005-01-27 | Paracor Medical, Inc. | Self-anchoring cardiac harness |
| US7513867B2 (en) * | 2003-07-16 | 2009-04-07 | Kardium, Inc. | Methods and devices for altering blood flow through the left ventricle |
| US7235042B2 (en) | 2003-09-16 | 2007-06-26 | Acorn Cardiovascular, Inc. | Apparatus and method for applying cardiac support device |
| US7158839B2 (en) | 2003-11-07 | 2007-01-02 | Paracor Medical, Inc. | Cardiac harness for treating heart disease |
| US7155295B2 (en) | 2003-11-07 | 2006-12-26 | Paracor Medical, Inc. | Cardiac harness for treating congestive heart failure and for defibrillating and/or pacing/sensing |
| WO2005070331A1 (en) | 2004-01-12 | 2005-08-04 | Paracor Medical, Inc. | Cardiac harness having interconnected strands |
| US7297104B2 (en) * | 2004-03-01 | 2007-11-20 | John Vanden Hoek | Seam closure device and methods |
| US20050267556A1 (en) * | 2004-05-28 | 2005-12-01 | Allan Shuros | Drug eluting implants to prevent cardiac apoptosis |
| US7402134B2 (en) * | 2004-07-15 | 2008-07-22 | Micardia Corporation | Magnetic devices and methods for reshaping heart anatomy |
| US7285087B2 (en) * | 2004-07-15 | 2007-10-23 | Micardia Corporation | Shape memory devices and methods for reshaping heart anatomy |
| WO2006055820A2 (en) * | 2004-11-19 | 2006-05-26 | G & L Consulting Llc | Biodegradable pericardial constraint system and method |
| US8672990B2 (en) * | 2005-05-27 | 2014-03-18 | Boston Scientific Scimed, Inc. | Fiber mesh controlled expansion balloon catheter |
| US7621866B2 (en) * | 2005-05-31 | 2009-11-24 | Ethicon, Inc. | Method and device for deployment of a sub-pericardial sack |
| PL1745812T3 (en) | 2005-07-22 | 2009-06-30 | Rowemed Ag Medical 4 Life | Valve for a fluid, in particular for being used in a mechanically actuated liquid pump |
| US7587247B2 (en) | 2005-08-01 | 2009-09-08 | Paracor Medical, Inc. | Cardiac harness having an optimal impedance range |
| US20070156113A1 (en) * | 2006-01-03 | 2007-07-05 | Heartcor | Organ shealth for percutaneous delivery of biological and pharmacological agents |
| US7749249B2 (en) | 2006-02-21 | 2010-07-06 | Kardium Inc. | Method and device for closing holes in tissue |
| US20070208217A1 (en) | 2006-03-03 | 2007-09-06 | Acorn Cardiovascular, Inc. | Self-adjusting attachment structure for a cardiac support device |
| US7727142B2 (en) | 2006-03-03 | 2010-06-01 | Acorn Cardiovascular, Inc. | Delivery tool for cardiac support device |
| US20070270882A1 (en) | 2006-05-19 | 2007-11-22 | Acorn Cardiovascular, Inc. | Pericardium management method for intra-pericardial surgical procedures |
| RU2312611C1 (en) * | 2006-05-22 | 2007-12-20 | Владимир Митрофанович Шипулин | Device for surgically treating ischemic and dilatation cardiomyopathy |
| US8449605B2 (en) | 2006-06-28 | 2013-05-28 | Kardium Inc. | Method for anchoring a mitral valve |
| US20080004489A1 (en) * | 2006-06-29 | 2008-01-03 | Acorn Cardiovascular, Inc. | Low friction delivery method for a cardiac support device |
| US20080004488A1 (en) | 2006-06-29 | 2008-01-03 | Acorn Cardiovascular, Inc. | Low friction delivery tool for a cardiac support device |
| US7877142B2 (en) * | 2006-07-05 | 2011-01-25 | Micardia Corporation | Methods and systems for cardiac remodeling via resynchronization |
| US7651462B2 (en) | 2006-07-17 | 2010-01-26 | Acorn Cardiovascular, Inc. | Cardiac support device delivery tool with release mechanism |
| US7837610B2 (en) | 2006-08-02 | 2010-11-23 | Kardium Inc. | System for improving diastolic dysfunction |
| US7641608B1 (en) | 2006-09-26 | 2010-01-05 | Acorn Cardiovascular, Inc. | Sectional cardiac support device and method of delivery |
| EP1920789A1 (en) | 2006-11-11 | 2008-05-14 | Universitätsklinikum Hamburg-Eppendorf | Pouch-like construct comprising mammalian tissue |
| US8192351B2 (en) | 2007-08-13 | 2012-06-05 | Paracor Medical, Inc. | Medical device delivery system having integrated introducer |
| US8092363B2 (en) | 2007-09-05 | 2012-01-10 | Mardil, Inc. | Heart band with fillable chambers to modify heart valve function |
| US8101116B2 (en) * | 2007-09-19 | 2012-01-24 | Ethicon, Inc. | Preformed support device and method and apparatus for manufacturing the same |
| US20090287304A1 (en) | 2008-05-13 | 2009-11-19 | Kardium Inc. | Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve |
| EP2417247A1 (en) | 2009-04-09 | 2012-02-15 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Cellular seeding and co-culture of a three dimensional fibroblast construct |
| EP2456373B1 (en) | 2009-07-21 | 2019-09-04 | Applied Medical Resources Corporation | Surgical access device comprising internal retractor |
| WO2011041571A2 (en) | 2009-10-01 | 2011-04-07 | Kardium Inc. | Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve |
| US9050066B2 (en) | 2010-06-07 | 2015-06-09 | Kardium Inc. | Closing openings in anatomical tissue |
| US8940002B2 (en) | 2010-09-30 | 2015-01-27 | Kardium Inc. | Tissue anchor system |
| US9072511B2 (en) | 2011-03-25 | 2015-07-07 | Kardium Inc. | Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve |
| WO2014059432A2 (en) | 2012-10-12 | 2014-04-17 | Mardil, Inc. | Cardiac treatment system and method |
| EP2943131B1 (en) * | 2013-01-09 | 2019-07-17 | Cook Medical Technologies LLC | Abdominal retractor |
| USD717954S1 (en) | 2013-10-14 | 2014-11-18 | Mardil, Inc. | Heart treatment device |
Citations (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3429584A (en) * | 1967-07-17 | 1969-02-25 | William E Hendricks | Three-wheeled velocipede |
| US3983863A (en) * | 1975-06-02 | 1976-10-05 | American Hospital Supply Corporation | Heart support for coronary artery surgery |
| US4048890A (en) * | 1975-11-17 | 1977-09-20 | Raskin S.A. | Punching tool die |
| US4428375A (en) * | 1982-02-16 | 1984-01-31 | Ellman Barry R | Surgical bag for splenorrhaphy |
| US4630597A (en) * | 1984-04-30 | 1986-12-23 | Adrian Kantrowitz | Dynamic aortic patch for thoracic or abdominal implantation |
| US4690134A (en) * | 1985-07-01 | 1987-09-01 | Snyders Robert V | Ventricular assist device |
| US4821723A (en) * | 1987-02-27 | 1989-04-18 | Intermedics Inc. | Biphasic waveforms for defibrillation |
| US4878890A (en) * | 1986-10-15 | 1989-11-07 | Ethicon, Inc. | Perihepatic prosthesis |
| US4936857A (en) * | 1987-02-23 | 1990-06-26 | Kulik Yaroslav P | Prosthetic pericardium |
| US4957477A (en) * | 1986-05-22 | 1990-09-18 | Astra Tech Ab | Heart assist jacket and method of using it |
| US5087243A (en) * | 1990-06-18 | 1992-02-11 | Boaz Avitall | Myocardial iontophoresis |
| US5131905A (en) * | 1990-07-16 | 1992-07-21 | Grooters Ronald K | External cardiac assist device |
| US5150706A (en) * | 1991-08-15 | 1992-09-29 | Cox James L | Cooling net for cardiac or transplant surgery |
| US5186711A (en) * | 1989-03-07 | 1993-02-16 | Albert Einstein College Of Medicine Of Yeshiva University | Hemostasis apparatus and method |
| US5192234A (en) * | 1991-04-26 | 1993-03-09 | Entrelec S.A. | Electrical terminal and a housing for electrical apparatus including such a terminal |
| US5256112A (en) * | 1992-08-07 | 1993-10-26 | Gates Power Drive Products, Inc. | Eccentric type belt tensioner |
| US5290217A (en) * | 1991-10-10 | 1994-03-01 | Earl K. Sipes | Method and apparatus for hernia repair |
| US5383840A (en) * | 1992-07-28 | 1995-01-24 | Vascor, Inc. | Biocompatible ventricular assist and arrhythmia control device including cardiac compression band-stay-pad assembly |
| US5385156A (en) * | 1993-08-27 | 1995-01-31 | Rose Health Care Systems | Diagnostic and treatment method for cardiac rupture and apparatus for performing the same |
| US5507779A (en) * | 1994-04-12 | 1996-04-16 | Ventritex, Inc. | Cardiac insulation for defibrillation |
| US5524633A (en) * | 1991-11-25 | 1996-06-11 | Advanced Surgical, Inc. | Self-deploying isolation bag |
| US5603337A (en) * | 1994-12-05 | 1997-02-18 | Jarvik; Robert | Two-stage cardiomyoplasty |
| US6645139B2 (en) * | 1997-06-21 | 2003-11-11 | Acorn Cardiovascular Inc. | Bag for at least partially enveloping a heart |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4048990A (en) | 1976-09-17 | 1977-09-20 | Goetz Robert H | Heart massage apparatus |
| SU1009457A1 (en) | 1981-07-15 | 1983-04-07 | Проблемная Лаборатория "Вспомогательного Кровообращения" Благовещенского Медицинского Института | Artificial pericardium |
| JPS60203250A (en) | 1984-03-29 | 1985-10-14 | 日本ゼオン株式会社 | heart surgery patch |
| US4827932A (en) | 1987-02-27 | 1989-05-09 | Intermedics Inc. | Implantable defibrillation electrodes |
| US4834707A (en) | 1987-09-16 | 1989-05-30 | Evans Phillip H | Venting apparatus and method for cardiovascular pumping application |
| US4976730A (en) | 1988-10-11 | 1990-12-11 | Kwan Gett Clifford S | Artificial pericardium |
| US5057117A (en) | 1989-04-27 | 1991-10-15 | The Research Foundation Of State University Of New York | Method and apparatus for hemostasis and compartmentalization of a bleeding internal bodily organ |
| US4973300A (en) | 1989-09-22 | 1990-11-27 | Pioneering Technologies, Inc. | Cardiac sling for circumflex coronary artery surgery |
| WO1992008500A1 (en) | 1990-11-09 | 1992-05-29 | Mcgill University | Cardiac assist method and apparatus |
| US5192314A (en) | 1991-12-12 | 1993-03-09 | Daskalakis Michael K | Synthetic intraventricular implants and method of inserting |
| US5256132A (en) | 1992-08-17 | 1993-10-26 | Snyders Robert V | Cardiac assist envelope for endoscopic application |
| US5356432B1 (en) | 1993-02-05 | 1997-02-04 | Bard Inc C R | Implantable mesh prosthesis and method for repairing muscle or tissue wall defects |
| AU1608895A (en) * | 1994-11-30 | 1996-06-19 | W.L. Gore & Associates, Inc. | Surgical device for protecting organs from formation of adhesions |
| GB9510624D0 (en) | 1995-05-25 | 1995-07-19 | Ellis Dev Ltd | Textile surgical implants |
| US5647380A (en) | 1995-06-07 | 1997-07-15 | W. L. Gore & Associates, Inc. | Method of making a left ventricular assist device |
| US5713954A (en) | 1995-06-13 | 1998-02-03 | Abiomed R&D, Inc. | Extra cardiac ventricular assist device |
| US5800528A (en) | 1995-06-13 | 1998-09-01 | Abiomed R & D, Inc. | Passive girdle for heart ventricle for therapeutic aid to patients having ventricular dilatation |
| FR2737106B1 (en) * | 1995-07-27 | 1997-10-03 | Cousin Biotech | RECONSTRUCTION PLATE WITH FIBRILLARY STRUCTURE, FLEXIBLE AND WITH MEMORY, FOR THE FIELD OF VISCERAL SURGERY |
| DE29517393U1 (en) | 1995-11-03 | 1996-02-01 | Hohmann, Claas, Dr.med., 78315 Radolfzell | Pericardial prosthesis |
| US5702343A (en) * | 1996-10-02 | 1997-12-30 | Acorn Medical, Inc. | Cardiac reinforcement device |
| DE29619294U1 (en) | 1996-11-07 | 1997-07-17 | Caić, Pero, 63450 Hanau | Heart cuff |
| US6050936A (en) | 1997-01-02 | 2000-04-18 | Myocor, Inc. | Heart wall tension reduction apparatus |
| US5961440A (en) | 1997-01-02 | 1999-10-05 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
| US6183411B1 (en) | 1998-09-21 | 2001-02-06 | Myocor, Inc. | External stress reduction device and method |
| US6077214A (en) | 1998-07-29 | 2000-06-20 | Myocor, Inc. | Stress reduction apparatus and method |
| US6045497A (en) | 1997-01-02 | 2000-04-04 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
| US6190408B1 (en) | 1998-03-05 | 2001-02-20 | The University Of Cincinnati | Device and method for restructuring the heart chamber geometry |
| US6260552B1 (en) | 1998-07-29 | 2001-07-17 | Myocor, Inc. | Transventricular implant tools and devices |
-
1998
- 1998-06-16 DE DE59811956T patent/DE59811956D1/en not_active Expired - Lifetime
- 1998-06-16 EP EP98933619A patent/EP0991373B1/en not_active Expired - Lifetime
- 1998-06-16 DE DE19826675A patent/DE19826675A1/en not_active Ceased
- 1998-06-16 WO PCT/EP1998/003619 patent/WO1998058598A1/en not_active Ceased
- 1998-06-16 JP JP50372399A patent/JP2002504841A/en active Pending
-
1999
- 1999-12-03 US US09/453,722 patent/US6416459B1/en not_active Expired - Fee Related
-
2002
- 2002-05-07 US US10/140,225 patent/US6645139B2/en not_active Expired - Fee Related
-
2003
- 2003-11-07 US US10/703,709 patent/US20040102678A1/en not_active Abandoned
Patent Citations (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3429584A (en) * | 1967-07-17 | 1969-02-25 | William E Hendricks | Three-wheeled velocipede |
| US3983863A (en) * | 1975-06-02 | 1976-10-05 | American Hospital Supply Corporation | Heart support for coronary artery surgery |
| US4048890A (en) * | 1975-11-17 | 1977-09-20 | Raskin S.A. | Punching tool die |
| US4428375A (en) * | 1982-02-16 | 1984-01-31 | Ellman Barry R | Surgical bag for splenorrhaphy |
| US4630597A (en) * | 1984-04-30 | 1986-12-23 | Adrian Kantrowitz | Dynamic aortic patch for thoracic or abdominal implantation |
| US4690134A (en) * | 1985-07-01 | 1987-09-01 | Snyders Robert V | Ventricular assist device |
| US4957477A (en) * | 1986-05-22 | 1990-09-18 | Astra Tech Ab | Heart assist jacket and method of using it |
| US4878890A (en) * | 1986-10-15 | 1989-11-07 | Ethicon, Inc. | Perihepatic prosthesis |
| US4936857A (en) * | 1987-02-23 | 1990-06-26 | Kulik Yaroslav P | Prosthetic pericardium |
| US4821723A (en) * | 1987-02-27 | 1989-04-18 | Intermedics Inc. | Biphasic waveforms for defibrillation |
| US5186711A (en) * | 1989-03-07 | 1993-02-16 | Albert Einstein College Of Medicine Of Yeshiva University | Hemostasis apparatus and method |
| US5087243A (en) * | 1990-06-18 | 1992-02-11 | Boaz Avitall | Myocardial iontophoresis |
| US5131905A (en) * | 1990-07-16 | 1992-07-21 | Grooters Ronald K | External cardiac assist device |
| US5192234A (en) * | 1991-04-26 | 1993-03-09 | Entrelec S.A. | Electrical terminal and a housing for electrical apparatus including such a terminal |
| US5150706A (en) * | 1991-08-15 | 1992-09-29 | Cox James L | Cooling net for cardiac or transplant surgery |
| US5290217A (en) * | 1991-10-10 | 1994-03-01 | Earl K. Sipes | Method and apparatus for hernia repair |
| US5524633A (en) * | 1991-11-25 | 1996-06-11 | Advanced Surgical, Inc. | Self-deploying isolation bag |
| US5383840A (en) * | 1992-07-28 | 1995-01-24 | Vascor, Inc. | Biocompatible ventricular assist and arrhythmia control device including cardiac compression band-stay-pad assembly |
| US5256112A (en) * | 1992-08-07 | 1993-10-26 | Gates Power Drive Products, Inc. | Eccentric type belt tensioner |
| US5385156A (en) * | 1993-08-27 | 1995-01-31 | Rose Health Care Systems | Diagnostic and treatment method for cardiac rupture and apparatus for performing the same |
| US5507779A (en) * | 1994-04-12 | 1996-04-16 | Ventritex, Inc. | Cardiac insulation for defibrillation |
| US5603337A (en) * | 1994-12-05 | 1997-02-18 | Jarvik; Robert | Two-stage cardiomyoplasty |
| US6645139B2 (en) * | 1997-06-21 | 2003-11-11 | Acorn Cardiovascular Inc. | Bag for at least partially enveloping a heart |
Cited By (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7695425B2 (en) | 1997-01-02 | 2010-04-13 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
| US8460173B2 (en) | 1997-01-02 | 2013-06-11 | Edwards Lifesciences, Llc | Heart wall tension reduction apparatus and method |
| US8267852B2 (en) | 1997-01-02 | 2012-09-18 | Edwards Lifesciences, Llc | Heart wall tension reduction apparatus and method |
| US7883539B2 (en) | 1997-01-02 | 2011-02-08 | Edwards Lifesciences Llc | Heart wall tension reduction apparatus and method |
| US7189199B2 (en) | 1997-01-02 | 2007-03-13 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
| US9756850B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US9756851B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US9756849B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US8187323B2 (en) | 1997-12-17 | 2012-05-29 | Edwards Lifesciences, Llc | Valve to myocardium tension members device and method |
| US20020029080A1 (en) * | 1997-12-17 | 2002-03-07 | Myocor, Inc. | Valve to myocardium tension members device and method |
| US8226711B2 (en) | 1997-12-17 | 2012-07-24 | Edwards Lifesciences, Llc | Valve to myocardium tension members device and method |
| US7981020B2 (en) | 1998-07-29 | 2011-07-19 | Edwards Lifesciences Llc | Transventricular implant tools and devices |
| US7722523B2 (en) | 1998-07-29 | 2010-05-25 | Edwards Lifesciences Llc | Transventricular implant tools and devices |
| US6908424B2 (en) | 1998-07-29 | 2005-06-21 | Myocor, Inc. | Stress reduction apparatus and method |
| US20080319256A1 (en) * | 1998-07-29 | 2008-12-25 | Myocor, Inc. | Transventricular implant tools and devices |
| US20020173694A1 (en) * | 1998-07-29 | 2002-11-21 | Myocor, Inc. | Stress reduction apparatus and method |
| US8439817B2 (en) | 1998-07-29 | 2013-05-14 | Edwards Lifesciences, Llc | Chordae capturing methods for stress reduction |
| US8579798B2 (en) | 1998-09-21 | 2013-11-12 | Edwards Lifesciences, Llc | External cardiac stress reduction method |
| US9198757B2 (en) | 2000-10-06 | 2015-12-01 | Edwards Lifesciences, Llc | Methods and devices for improving mitral valve function |
| US7766812B2 (en) | 2000-10-06 | 2010-08-03 | Edwards Lifesciences Llc | Methods and devices for improving mitral valve function |
| US8092367B2 (en) | 2001-09-07 | 2012-01-10 | Mardil, Inc. | Method for external stabilization of the base of the heart |
| US20070129598A1 (en) * | 2001-09-07 | 2007-06-07 | Raman Jaishanker | Method and apparatus for external stabilization of the heart |
| US8715160B2 (en) | 2001-09-07 | 2014-05-06 | Mardil, Inc. | Method and apparatus for external stabilization of the heart |
| US8128553B2 (en) | 2001-09-07 | 2012-03-06 | Mardil, Inc. | Method and apparatus for external stabilization of the heart |
| US20080215074A1 (en) * | 2001-09-07 | 2008-09-04 | Raman Jaishankar | Method and apparatus for external stabilization of the heart |
| US9289298B2 (en) | 2001-09-07 | 2016-03-22 | Mardil, Inc. | Method and apparatus for external stabilization of the heart |
| US8070805B2 (en) | 2002-01-09 | 2011-12-06 | Edwards Lifesciences Llc | Devices and methods for heart valve treatment |
| US7678145B2 (en) | 2002-01-09 | 2010-03-16 | Edwards Lifesciences Llc | Devices and methods for heart valve treatment |
| US7077862B2 (en) | 2002-01-09 | 2006-07-18 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US8506624B2 (en) | 2002-01-09 | 2013-08-13 | Edwards Lifesciences, Llc | Devices and methods for heart valve treatment |
| US7247134B2 (en) | 2002-11-12 | 2007-07-24 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US7666224B2 (en) | 2002-11-12 | 2010-02-23 | Edwards Lifesciences Llc | Devices and methods for heart valve treatment |
| US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
| US9215867B2 (en) | 2004-10-07 | 2015-12-22 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US20060154359A1 (en) * | 2004-10-07 | 2006-07-13 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US7651835B2 (en) | 2004-10-07 | 2010-01-26 | Transmedics, Inc. | Method of timing pulsatile flow of normothermic perfusate to the heart |
| US10321676B2 (en) | 2004-10-07 | 2019-06-18 | Transmedics, Inc. | System and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US12396454B2 (en) | 2004-10-07 | 2025-08-26 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US10314303B2 (en) | 2004-10-07 | 2019-06-11 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US11191263B2 (en) | 2004-10-07 | 2021-12-07 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US11570985B2 (en) | 2004-10-07 | 2023-02-07 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US12137683B2 (en) | 2004-10-07 | 2024-11-12 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US9894894B2 (en) | 2004-10-07 | 2018-02-20 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US11723357B2 (en) | 2004-10-07 | 2023-08-15 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US8465970B2 (en) | 2004-10-07 | 2013-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US20070275364A1 (en) * | 2004-10-07 | 2007-11-29 | Waleed Hassanein | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US20060148062A1 (en) * | 2004-10-07 | 2006-07-06 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US20070190636A1 (en) * | 2004-10-07 | 2007-08-16 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US8585380B2 (en) | 2004-10-07 | 2013-11-19 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US20060154357A1 (en) * | 2004-10-07 | 2006-07-13 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US9301519B2 (en) | 2004-10-07 | 2016-04-05 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US9055740B2 (en) | 2004-10-07 | 2015-06-16 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US20060154358A1 (en) * | 2004-10-07 | 2006-07-13 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US20060160204A1 (en) * | 2004-10-07 | 2006-07-20 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US10736314B2 (en) | 2004-10-07 | 2020-08-11 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US10039276B2 (en) | 2005-06-28 | 2018-08-07 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US11844345B2 (en) | 2005-06-28 | 2023-12-19 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US20060292544A1 (en) * | 2005-06-28 | 2006-12-28 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US20090049015A1 (en) * | 2005-10-18 | 2009-02-19 | Justsystems Corporation | Data management device and terminal device |
| US8822203B2 (en) | 2006-04-19 | 2014-09-02 | Transmedics, Inc. | Systems and methods for ex vivo organ care |
| US9259318B2 (en) | 2006-04-19 | 2016-02-16 | Beth Israel Deaconess Medical Center | Pericardial reinforcement device |
| US20110136096A1 (en) * | 2006-04-19 | 2011-06-09 | Transmedics, Inc. | Systems and Methods for Ex Vivo Organ Care |
| US8535934B2 (en) | 2006-04-19 | 2013-09-17 | Transmedics, Inc. | Systems and methods for ex vivo organ care |
| US20080017194A1 (en) * | 2006-04-19 | 2008-01-24 | Transmedics, Inc | Systems and methods for ex vivo organ care |
| US20080021266A1 (en) * | 2006-04-19 | 2008-01-24 | Laham Roger J | Pericardial reinforcement device |
| US20080091057A1 (en) * | 2006-10-11 | 2008-04-17 | Cardiac Pacemakers, Inc. | Method and apparatus for passive left atrial support |
| US11917991B2 (en) | 2007-03-20 | 2024-03-05 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US20080234768A1 (en) * | 2007-03-20 | 2008-09-25 | Transmedics, Inc | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US12207649B2 (en) | 2007-03-20 | 2025-01-28 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US10327443B2 (en) | 2007-03-20 | 2019-06-25 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US20090197292A1 (en) * | 2008-01-31 | 2009-08-06 | Transmedics, Inc | Systems and methods for ex vivo lung care |
| US9247728B2 (en) | 2008-01-31 | 2016-02-02 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| US20090197325A1 (en) * | 2008-01-31 | 2009-08-06 | Transmedics, Inc | SYSTEMS AND METHODS FOR Ex vivo LUNG CARE |
| US12317888B2 (en) | 2008-01-31 | 2025-06-03 | Transmedics, Inc | Systems and methods for ex vivo lung care |
| US20090197241A1 (en) * | 2008-01-31 | 2009-08-06 | Transmedics, Inc | Systems and methods for ex vivo lung care |
| US10750738B2 (en) | 2008-01-31 | 2020-08-25 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| US9814230B2 (en) | 2008-01-31 | 2017-11-14 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| US9516875B2 (en) | 2008-01-31 | 2016-12-13 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| US8420380B2 (en) | 2008-01-31 | 2013-04-16 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| US9462802B2 (en) | 2008-01-31 | 2016-10-11 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| US11856944B2 (en) | 2011-04-14 | 2024-01-02 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
| US10076112B2 (en) | 2014-06-02 | 2018-09-18 | Transmedic, Inc. | Ex vivo organ care system |
| US11944088B2 (en) | 2014-06-02 | 2024-04-02 | Transmedics, Inc. | Ex vivo organ care system |
| US11903381B2 (en) | 2014-06-02 | 2024-02-20 | Transmedics, Inc. | Ex vivo organ care system |
| US11154050B2 (en) | 2014-06-02 | 2021-10-26 | Transmedics, Inc. | Ex vivo organ care system |
| US11963526B2 (en) | 2014-12-12 | 2024-04-23 | Transmedics, Inc. | Apparatus and method for organ perfusion |
| US12185718B2 (en) | 2015-09-09 | 2025-01-07 | Transmedics, Inc. | Aortic cannula for ex vivo organ care system |
| US10194655B2 (en) | 2015-09-09 | 2019-02-05 | Transmedics, Inc. | Aortic cannula for ex vivo organ care system |
| US11122795B2 (en) | 2015-09-09 | 2021-09-21 | Transmedics, Inc. | Aortic cannula for ex vivo organ care system |
| US12127554B2 (en) | 2016-05-30 | 2024-10-29 | Transmedics, Inc. | Apparatus and method for ex vivo lung ventilation with a varying exterior pressure |
Also Published As
| Publication number | Publication date |
|---|---|
| DE19826675A1 (en) | 1999-03-04 |
| EP0991373A1 (en) | 2000-04-12 |
| DE59811956D1 (en) | 2004-10-21 |
| US6416459B1 (en) | 2002-07-09 |
| EP0991373B1 (en) | 2004-09-15 |
| US20020133055A1 (en) | 2002-09-19 |
| US6645139B2 (en) | 2003-11-11 |
| JP2002504841A (en) | 2002-02-12 |
| WO1998058598A1 (en) | 1998-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6416459B1 (en) | Bag for at least partially enveloping a heart | |
| US20110196467A1 (en) | Blood vessel wrap | |
| US8852275B2 (en) | Intraocular lens supporter | |
| US6755779B2 (en) | Apparatus and method for delivery of cardiac constraint jacket | |
| EP1830754B1 (en) | Radially compressed dehydrated spinal nucleus implants | |
| US6482146B1 (en) | Cardiac disease treatment and device | |
| EP0114867B1 (en) | Dilatation device for the cervix | |
| US4573999A (en) | Human breast prosthesis | |
| US7404793B2 (en) | Heart failure treatment device and method | |
| US20090204123A1 (en) | Lens Delivery System Cartridge | |
| WO2011115860A2 (en) | Accommodating intraocular lens assembly | |
| US20130310843A1 (en) | Plunger system for intraocular lens surgery | |
| KR101637555B1 (en) | Implant for plastic operation of virgina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |