US20030166904A1 - Human narcolepsy gene - Google Patents

Abstract

The gene for hypocretin (orexin) receptor 2 (HCRTR2), which is associated with narcolepsy, is disclosed. Also described are methods of diagnosis of narcolepsy, pharmaceutical compositions comprising nucleic acids comprising the HCRTR2 gene, as well as methods of therapy of narcolepsy.

Description

RELATED APPLICATION
• This application is a continuation of U.S. application Ser. No. 09/426,290, filed Oct. 25, 1999. The entire teachings of the above application are incorporated herein by reference.[0001]
BACKGROUND OF THE INVENTION
• Narcolepsy, a disorder which affects approximately 1 in 2,000 individuals, is characterized by daytime sleepiness, sleep fragmentation, and symptoms of abnormal rapid eye movement (REM) sleep that include cataplexy (loss of muscle tone), sleep paralysis, and hypnagogic hallucinations (Aldrich, M. S., [0002] Neurology 42:34-43 (1992); Siegel, J. M., Cell 98:409-412 (1999)). In humans, susceptibility to narcolepsy has been associated with a specific human leukocyte antigen (HLA) alleles, including DQB1*0602 (Mignot, E., Neurology 50:S16-22 (1998); Kadotani, H. et al., Genome Res. 8:427-434 (1998); Faraco, J. et al., J. Hered. 90:129-132 (1999)); however, attempts to verify narcolepsy as an autoimmune disorder have failed (Mignot, E. et al., Adv. Neuroimmunol. 5:23-37 (1995); Mignot, E., Curr. Opin. Pulm. Med. 2:482-487 (1996)). In a canine model of narcolepsy, the disorder is transmitted as an autosomal recessive trait, canarc-1 (Foutz, A. S. et al., Sleep 1:413-421 91979); Baker, T. L. and Dement, W. C., Brain Mechanisms of Sleep (D. J. McGinty et al., eds., New York: Raven Press, pp. 199-233 (1985)). The possibility of linkage between canarc-1 and the canine major histocompatibility complex has been excluded (Mignot, E. et al, Proc. Natl. Acad. Sci. USA 88:3475-3478 (1991)).
• A mutation in the hypocretin (orexin) [0003] receptor 2 gene in canines has been identified in narcolepsy (Lin, L. et al., Cell 98:365-376 (1999)); Hypocrexins/orexins (orexin-A and -B) are neuropeptides associated with regulation of food consumption (de Lecea, L., et al., Proc. natl. Acad. Sci. USA 95:322-327 (1998); Sakurai, T. et al., Cell 92:573-585 (1998)) as well as other possible functions (Peyron, C. et al., J. Neurosci. 18:9996-10015 (1998)). Human cDNA of receptors for orexins have been cloned (Sakurai, T. et al., Cell 92:573-585 (1998)), however, full human genes for the orexin receptors have not yet been identified.
• Diagnosis of narcolepsy is difficult, as it is necessary to distinguish narcolepsy from other conditions such as chronic fatigue syndrome or other sleep disorders (Ambrogetti, A. and Olson, L. C., [0004] Med. J Aust. 160:426-429 (1994); Aldrich, M. S., Neurology 50:S2-7 (1998)). Methods of diagnosing narcolepsy based on specific criteria would facilitate identification of the disease, reduce the time and expense associated with diagnosis, and expedite commencement of treatment.
SUMMARY OF THE INVENTION
• As described herein, a full gene for the human hypocretin (orexin) receptor 2 (HCRTR2) has been identified. The sequence of the HCRTR2 gene as described herein is shown in FIG. 1 (SEQ ID NO: 1). Accordingly, this invention pertains to an isolated nucleic acid molecule containing the HCRTR2 gene. The invention also relates to DNA constructs comprising the nucleic acid molecules described herein operatively linked to a regulatory sequence, and to recombinant host cells, such as bacterial cells, fungal cells, plant cells, insect cells and mammalian cells, comprising the nucleic acid molecules described herein operatively linked to a regulatory sequence. The invention also pertains to methods of diagnosing narcolepsy in an individual. The methods include detecting the presence of a mutation in the HCRTR2 gene. The invention additionally pertains to pharmaceutical compositions comprising the HCRTR2 nucleic acids of the invention. The invention further pertains to methods of treating narcolepsy, by administering HCRTR2 nucleic acids of the invention or compositions comprising the HCRTR2 nucleic acids. The methods of the invention allow the accurate diagnosis of narcolepsy and reduce the need for time-consuming and expensive sleep laboratory assessments.[0005]
BRIEF DESCRIPTION OF THE DRAWINGS
• FIGS. 1A to [0006] 1AY depict the sequence of the human orexin receptor 2 gene (SEQ ID NO:1) and the encoded receptor (SEQ ID NO:2).
• The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings [0007]
DETAILED DESCRIPTION OF THE INVENTION
• The present invention relates to a human hypocretin (orexin) receptor 2 (HCRTR2) gene, and the relationship of the gene to narcolepsy. As described herein, Applicants have isolated the HCRTR2 gene. The gene and its products are implicated in the pathogenesis of narcolepsy, as mutations in a closely related receptor, hypocretin (orexin) [0008] receptor 2, have been associated with the presence of narcolepsy in a well-established canine model of narcolepsy (Lin, L. et al., Cell 98:365-376 (1999)).
NUCLEIC ACIDS OF THE INVENTION
• Accordingly, the invention pertains to an isolated nucleic acid molecule containing the human HCRTR2 gene. The term, “HCRTR2 gene,” refers to an isolated genomic nucleic acid molecule that encodes the human hypocretin (orexin) [0009] receptor 2. As used herein, the term, “genomic nucleic acid molecule” indicates that the nucleic acid molecule contains introns and exons as are found in genomic DNA (i.e., not cDNA). The nucleic acid molecules can be double-stranded or single-stranded; single stranded nucleic acid molecules can be either the coding (sense) strand or the non-coding (antisense) strand. The nucleic acid molecule can additionally contain a marker sequence, for example, a nucleotide sequence which encodes a polypeptide, to assist in isolation or purification of the polypeptide. Such sequences include, but are not limited to, those which encode a glutathione-S-transferase (GST) fusion protein and those which encode a hemagglutinin A (HA) peptide marker from influenza. In a preferred embodiment, the nucleic acid molecule has the sequence shown in the Figure (SEQ ID NO: 1).
• As used herein, an “isolated” or “substantially pure” gene or nucleic acid molecule is intended to mean a gene which is not flanked by nucleotide sequences which normally (in nature) flank the gene (as in other genomic sequences). Thus, an isolated gene can include a gene which is synthesized chemically or by recombinant means. Thus, recombinant DNA contained in a vector are included in the definition of “isolated” as used herein. Also, isolated nucleotide sequences include recombinant DNA molecules in heterologous host cells, as well as partially or substantially purified DNA molecules in solution. Such isolated nucleotide sequences are useful in the manufacture of the encoded protein, as probes for isolating homologous sequences (e.g., from other mammalian species), for gene mapping (e.g., by in situ hybridization with chromosomes), or for detecting expression of the HCRTR2 gene in tissue (e.g., human tissue), such as by Northern blot analysis. [0010]
• The present invention also encompasses variations of the nucleic acid sequences of the invention. Such variations can be naturally-occurring, such as in the case of allelic variation, or non-naturally-occurring, such as those induced by various mutagens and mutagenic processes. Intended variations include, but are not limited to, addition, deletion and substitution of one or more nucleotides which can result in conservative or non-conservative amino acid changes, including additions and deletions. Preferably, the nucleotide or amino acid variations are silent or conserved; that is, they do not alter the characteristics or activity of the hypocretin (orexin) [0011] receptor 2.
• Other alterations of the nucleic acid molecules of the invention can include, for example, labeling, methylation, internucleotide modifications such as uncharged linkages (e.g., methyl phosphonates, phosphotriesters, phosphoamidates, carbamates), charged linkages (e.g., phosphorothioates, phosphorodithioates), pendent moieties (e.g., polypeptides), intercalators (e.g., acridine, psoralen), chelators, alkylators, and modified linkages (e.g., alpha anomeric nucleic acids). Also included are synthetic molecules that mimic nucleic acid molecules in the ability to bind to a designated sequences via hydrogen bonding and other chemical interactions. Such molecules include, for example, those in which peptide linkages substitute for phosphate linkages in the backbone of the molecule. [0012]
• The invention also relates to fragments of the isolated nucleic acid molecules described herein. The term “fragment” is intended to encompass a portion of a nucleic acid sequence described herein which is from at least about 25 contiguous nucleotides to at least about 50 contiguous nucleotides or longer in length. One or more introns can also be present. Such fragments are useful as probes, e.g., for diagnostic methods, as described below and also as primers or probes. Particularly preferred primers and probes selectively hybridize to a nucleic acid molecule containing the HCRTR2 gene described herein. [0013]
• The invention also pertains to nucleic acid molecules which hybridize under high stringency hybridization conditions, such as for selective hybridization, to a nucleotide sequence described herein (e.g., nucleic acid molecules which specifically hybridize to a nucleic acid containing the HCRTR2 gene described herein). Hybridization probes are oligonucleotides which bind in a base-specific manner to a complementary strand of nucleic acid. Suitable probes include polypeptide nucleic acids, as described in (Nielsen et al., [0014] Science 254, 1497-1500 (1991)).
• Such nucleic acid molecules can be detected and/or isolated by specific hybridization (e.g., under high stringency conditions). “Stringency conditions” for hybridization is a term of art which refers to the incubation and wash conditions, e.g., conditions of temperature and buffer concentration, which permit hybridization of a particular nucleic acid to a second nucleic acid; the first nucleic acid may be perfectly (i.e., 100%) complementary to the second, or the first and second may share some degree of complementarity which is less than perfect (e.g., 60%, 75%, 85%, 95%). For example, certain high stringency conditions can be used which distinguish perfectly complementary nucleic acids from those of less complementarity. [0015]
• “High stringency conditions”, “moderate stringency conditions” and “low stringency conditions” for nucleic acid hybridizations are explained on pages 2.10.1-2.10.16 and pages 6.3.1-6 in [0016] Current Protocols in Molecular Biology (Ausubel, F. M. et al., “Current Protocols in Molecular Biology”, John Wiley & Sons, (1998)) the teachings of which are hereby incorporated by reference. The exact conditions which determine the stringency of hybridization depend not only on ionic strength (e.g., 0.2×SSC, 0.1×SSC), temperature (e.g., room temperature, 42° C., 68° C.) and the concentration of destabilizing agents such as formamide or denaturing agents such as SDS, but also on factors such as the length of the nucleic acid sequence, base composition, percent mismatch between hybridizing sequences and the frequency of occurrence of subsets of that sequence within other non-identical sequences. Thus, high, moderate or low stringency conditions can be determined empirically. By varying hybridization conditions from a level of stringency at which no hybridization occurs to a level at which hybridization is first observed, conditions which will allow a given sequence to hybridize (e.g., selectively) with the most similar sequences in the sample can be determined.
• Exemplary conditions are described in Krause, M. H. and S. A. Aaronson, [0017] Methods in Enzymology, 200:546-556 (1991). Also, in, Ausubel, et al., “Current Protocols in Molecular Biology”, John Wiley & Sons, (1998), which describes the determination of washing conditions for moderate or low stringency conditions. Washing is the step in which conditions are usually set so as to determine a minimum level of complementarity of the hybrids. Generally, starting from the lowest temperature at which only homologous hybridization occurs, each ° C. by which the final wash temperature is reduced (holding SSC concentration constant) allows an increase by 1% in the maximum extent of mismatching among the sequences that hybridize. Generally, doubling the concentration of SSC results in an increase in T_m of ˜17° C. Using these guidelines, the washing temperature can be determined empirically for high, moderate or low stringency, depending on the level of mismatch sought.
• For example, a low stringency wash can comprise washing in a solution containing 0.2×SSC/0.1% SDS for 10 min at room temperature; a moderate stringency wash can comprise washing in a prewarmed solution (42° C.) solution containing 0.2×SSC/0.1% SDS for 15 min at 42° C.; and a high stringency wash can comprise washing in prewarmed (68° C.) solution containing 0.1×SSC/0.1% SDS for 15 min at 68° C. Furthermore, washes can be performed repeatedly or sequentially to obtain a desired result as known in the art. Equivalent conditions can be determined by varying one or more of the parameters given as an example, as known in the art, while maintaining a similar degree of identity or similarity between the target nucleic acid molecule and the primer or probe used. [0018]
• Hybridizable nucleic acid molecules are useful as probes and primers, e.g., for diagnostic applications, as described below. As used herein, the term “primer” refers to a single-stranded oligonucleotide which acts as a point of initiation of template-directed DNA synthesis under appropriate conditions (e.g., in the presence of four different nucleoside triphosphates and an agent for polymerization, such as, DNA or RNA polymerase or reverse transcriptase) in an appropriate buffer and at a suitable temperature. The appropriate length of a primer depends on the intended use of the primer, but typically ranges from 15 to 30 nucleotides. Short primer molecules generally require cooler temperatures to form sufficiently stable hybrid complexes with the template. A primer need not reflect the exact sequence of the template, but must be sufficiently complementary to hybridize with a template. The term “primer site” refers to the area of the target DNA to which a primer hybridizes. The term “primer pair” refers to a set of primers including a 5′ (upstream) primer that hybridizes with the 5′ end of the DNA sequence to be amplified and a 3′ (downstream) primer that hybridizes with the complement of the 3′ end of the sequence to be amplified. [0019]
• The invention also pertains to nucleotide sequences which have a substantial identity with the nucleotide sequences described herein; particularly preferred are nucleotide sequences which have at least about 70%, and more preferably at least about 80% identity, and even more preferably at least about 90% identity, with nucleotide sequences described herein. Particularly preferred in this instance are nucleotide sequences encoding hypocretin (orexin) [0020] receptor 2.
• To determine the percent identity of two nucleotide sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in the sequence of a first nucleotide sequence). The nucleotides at corresponding nucleotide positions are then compared. When a position in the first sequence is occupied by the same nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % identity=# of identical positions/total # of positions×100). [0021]
• The determination of percent identity between two sequences can be accomplished using a mathematical algorithm. A preferred, non-limiting example of a mathematical algorithm utilized for the comparison of two sequences is the algorithm of Karlin et al. ([0022] Proc. Natl. Acad. Sci. USA, 90:5873-5877 (1993)). Such an algorithm is incorporated into the NBLAST program which can be used to identify sequences having the desired identity to nucleotide sequences of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al. (Nucleic Acids Res, 25:3389-3402 (1997)). When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., NBLAST) can be used. See http://www.ncbi.nlm.nih.gov. In one embodiment, parameters for sequence comparison can be set at W=12. Parameters can also be varied (e.g., W=5 or W=20). The value “W” determines how many continuous nucleotides must be identical for the program to identify two sequences as containing regions of identity.
• The invention also provides expression vectors containing a nucleic acid comprising the HCRTR2 gene, operatively linked to at least one regulatory sequence. Many such vectors are commercially available, and other suitable vectors can be readily prepared by the skilled artisan. “Operatively linked” is intended to mean that the nucleic acid sequence is linked to a regulatory sequence in a manner which allows expression of the nucleic acid sequence. Regulatory sequences are art-recognized and are selected to produce a hypocretin (orexin) [0023] receptor 2. Accordingly, the term “regulatory sequence” includes promoters, enhancers, and other expression control elements such as those described in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). For example, the native regulatory sequences or regulatory sequences native to the transformed host cell can be employed. It should be understood that the design of the expression vector may depend on such factors as the choice of the host cell to be transformed and/or the receptor desired to be expressed. For instance, the gene of the present invention can be expressed by ligating the gene into a vector suitable for expression in either prokaryotic cells, eukaryotic cells or both (see, for example, Broach, et al., Experimental Manipulation of Gene Expression, ed. M. Inouye (Academic Press, 1983) p. 83; Molecular Cloning: A Laboratory Manual, 2nd Ed., ed. Sambrook et al. (Cold Spring Harbor Laboratory Press, 1989) Chapters 16 and 17). Typically, expression constructs will contain one or more selectable markers, including, but not limited to, the gene that encodes dihydrofolate reductase and the genes that confer resistance to neomycin, tetracycline, ampicillin, chloramphenicol, kanamycin and streptomycin resistance. Vectors can also include, for example, an autonomously replicating sequence (ARS), expression control sequences, ribosome-binding sites, RNA splice sites, polyadenylation sites, transcriptional terminator sequences, secretion signals and mRNA stabilizing sequences.
• Prokaryotic and eukaryotic host cells transformed by the described vectors are also provided by this invention. For instance, cells which can be transformed with the vectors of the present invention include, but are not limited to, bacterial cells such as [0024] E. coli (e.g., E. coli K12 strains), Streptomyces, Pseudomonas, Serratia marcescens and Salmonella typhimurium, insect cells (baculovirus), including Drosophila, fungal cells, such as yeast cells, plant cells and mammalian cells, such as thymocytes, Chinese hamster ovary cells (CHO), and COS cells. The host cells can be transformed by the described vectors by various methods (e.g., electroporation, transfection using calcium chloride, rubidium chloride, calcium phosphate, DEAE-dextran, or other substances; microprojectile bombardment; lipofection, infection where the vector is an infectious agent such as a retroviral genome, and other methods), depending on the type of cellular host.
• The nucleic acid molecules of the present invention can be produced, for example, by replication in a suitable host cell, as described above. Alternatively, the nucleic acid molecules can also be produced by chemical synthesis. [0025]
• The nucleotide sequences of the nucleic acid molecules described herein (e.g., a nucleic acid molecule comprising SEQ ID NO: 1) can be amplified by methods known in the art. For example, this can be accomplished by e.g., PCR. See generally [0026] PCR Technology: Principles and Applications for DNA Amplification (ed. H. A. Erlich, Freeman Press, New York, N.Y., 1992); PCR Protocols: A Guide to Methods and Applications (eds. Innis, et al., Academic Press, San Diego, Calif., 1990); Mattila et al., Nucleic Acids Res. 19, 4967 (1991); Eckert et al., PCR Methods and Applications 1, 17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Pat. 4,683,202.
• Other suitable amplification methods include the ligase chain reaction (LCR) (see Wu and Wallace, [0027] Genomics 4, 560 (1989), Landegren et al., Science 241, 1077 (1988), transcription amplification (Kwoh et al., Proc. Natl. Acad. Sci. USA 86, 1173 (1989)), and self-sustained sequence replication (Guatelli et al., Proc. Nat. Acad. Sci. USA, 87, 1874 (1990)) and nucleic acid based sequence amplification (NASBA). The latter two amplification methods involve isothermal reactions based on isothermal transcription, which produce both single stranded RNA (ssRNA) and double stranded DNA (dsDNA) as the amplification products in a ratio of about 30 or 100 to 1, respectively.
• The amplified DNA can be radiolabeled and used as a probe for screening a library or other suitable vector to identify homologous nucleotide sequences. Corresponding clones can be isolated, DNA can be obtained following in vivo excision, and the cloned insert can be sequenced in either or both orientations by art recognized methods, to identify the correct reading frame encoding a protein of the appropriate molecular weight. For example, the direct analysis of the nucleotide sequence of homologous nucleic acid molecules of the present invention can be accomplished using either the dideoxy chain termination method or the Maxam Gilbert method (see Sambrook et al., [0028] Molecular Cloning, A Laboratory Manual (2nd Ed., CSHP, New York 1989); Zyskind et al., Recombinant DNA Laboratory Manual, (Acad. Press, 1988)). Using these or similar methods, the protein(s) and the DNA encoding the protein can be isolated, sequenced and further characterized.
METHODS OF DIAGNOSIS
• The nucleic acids and the proteins described above can be used to detect, in an individual, a mutation in the HCRTR2 gene that is associated with narcolepsy. In one embodiment of the invention, diagnosis of narcolepsy is made by detecting a mutation in the HCRTR2 gene. The mutation can be the insertion or deletion of a single nucleotide, or of more than one nucleotide, resulting in a frame shift mutation; the change of at least one nucleotide, resulting in a change in the encoded amino acid; the change of at least one nucleotide, resulting in the generation of a premature stop codon; the deletion of several nucleotides, resulting in a deletion of one or more amino acids encoded by the nucleotides; the insertion of one or several nucleotides, such as by unequal recombination or gene conversion, resulting in an interruption of the coding sequence of the gene; duplication of all or a part of the gene; transposition of all or a part of the gene; or rearrangement of all or a part of the gene. More than one such mutation may be present in a single gene. Such sequence changes cause a mutation in the receptor encoded by the HCRTR2 gene. For example, if the mutation is a frame shift mutation, the frame shift can result in a change in the encoded amino acids, and/or can result in the generation of a premature stop codon, causing generation of a truncated receptor. Alternatively, a mutation associated with narcolepsy can be a synonymous mutation in one or more nucleotides (i.e., a mutation that does not result in a change in the receptor encoded by the HCRTR2 gene, such as a mutation in an intron or an untranslated portion of the gene). Such a polymorphism may alter splicing sites, affect the stability or transport of mRNA, or otherwise affect the transcription or translation of the gene. A HCRTR2 gene that has any of the mutations described above is referred to herein as a “mutant gene.” It is likely that a mutation in the HCRTR2 gene is associated with narcolepsy in humans because of the association between a mutation in the HCRTR2 gene and narcolepsy in dogs (Lin, L. et al., [0029] Cell 98:365-376 (1999), the entire teachings of which are incorporated herein by reference). In a preferred embodiment, the mutation in the HCRTR2 gene is to a deletion mutation, for example, a deletion that corresponds to the deletions found in the hypocretin (orexin) receptor 2 in narcoleptic dogs as described by Lin et al., supra (e.g., a deletion of one or more exons, such as a deletion of the fourth exon, that can be caused by insertion of one or more nucleotides upstream of the splice site of the exon, or a deletion of exon 6, that can be caused by a G to A transition in the splice junction consensus sequence). In another preferred embodiment, the mutation in the HCRTR2 gene is mutation that effects a “knockout” of the entire gene, such as deletion of the first exon as described by Chemelli, R. M. et al, (Cell 98:437-451 (1999), the entire teachings of which are incorporated herein). In a third preferred embodiment, the mutation in the HCRTR2 gene is a mutation in an intron, that affects splicing (joining of exons) during translation of the HCRTR2 gene.
• In a first method of diagnosing narcolepsy, hybridization methods, such as Southern analysis, are used (see Current Protocols in Molecular Biology, Ausubel, F. et al., eds., John Wiley & Sons, including all supplements through 1999). For example, a test sample of genomic DNA, RNA, or cDNA, is obtained from an individual suspected of having (or carrying a defect for) narcolepsy (the “test individual”). The individual can be an adult, child, or fetus. The test sample can be from any source which contains genomic DNA, such as a blood sample, sample of amniotic fluid, sample of cerebrospinal fluid, or tissue sample from skin, muscle, placenta, gastrointestinal tract or other organs. A test sample of DNA from fetal cells or tissue can be obtained by appropriate methods, such as by amniocentesis or chorionic villus sampling. The DNA, RNA, or cDNA sample is then examined to determine whether a mutation in the HCRTR2 gene is present. The presence of the mutation can be indicated by hybridization of the gene in the test sample to a nucleic acid probe. A “nucleic acid probe”, as used herein, can be a DNA probe or an RNA probe; the nucleic acid probe contains at least one mutation in the HCRTR2 gene. The probe can be one of the nucleic acid molecules described above (e.g., the gene, a vector comprising the gene, etc.) [0030]
• To diagnose narcolepsy by hybridization, a hybridization sample is formed by contacting the test sample containing a HCRTR2 gene, with at least one nucleic acid probe. The hybridization sample is maintained under conditions which are sufficient to allow specific hybridization of the nucleic acid probe to the HCRTR2 gene. “Specific hybridization”, as used herein, indicates exact hybridization (e.g., with no mismatches). Specific hybridization can be performed under high stringency conditions or moderate stringency conditions, for example, as described above. In a particularly preferred embodiment, the hybridization conditions for specific hybridization are high stringency. [0031]
• Specific hybridization, if present, is then detected using standard methods. If specific hybridization occurs between the nucleic acid probe and the HCRTR2 gene in the test sample, then the HCRTR2 gene has the mutation that is present in the nucleic acid probe. More than one nucleic acid probe can also be used concurrently in this method. Specific hybridization of any one of the nucleic acid probes is indicative of a mutation in the HCRTR2 gene, and is therefore diagnostic for narcolepsy. [0032]
• In another hybridization method, Northern analysis (see Current Protocols in Molecular Biology, Ausubel, F. et al., eds., John Wiley & Sons, supra) is used to identify the presence of a mutation associated with narcolepsy. For Northern analysis, a test sample of RNA is obtained from the individual by appropriate means. Specific hybridization of a nucleic acid probe, as described above, to RNA from the individual is indicative of a mutation in the HCRTR2 gene, and is therefore diagnostic for narcolepsy For representative examples of use of nucleic acid probes, see, for example, U.S. Pat. Nos. 5,288,611 and 4,851,330. Alternatively, a peptide nucleic acid (PNA) probe can be used instead of a nucleic acid probe in the hybridization methods described above. PNA is a DNA mimic having a peptide-like, inorganic backbone, such as N-(2-aminoethyl)glycine units, with an organic base (A, G, C, T or U) attached to the glycine nitrogen via a methylene carbonyl linker (see, for example, Nielsen, P. E. et al., [0033] Bioconjugate Chemistry, 1994, 5, American Chemical Society, p. 1 (1994). The PNA probe can be designed to specifically hybridize to a gene having a polymorphism associated with autoimmune disease. Hybridization of the PNA probe to the HCRTR2 gene is diagnostic for narcolepsy.
• In another method of the invention, mutation analysis by restriction digestion can be used to detect mutant genes, or genes containing polymorphisms, if the mutation or polymorphism in the gene results in the creation or elimination of a restriction site. A test sample containing genomic DNA is obtained from the individual. Polymerase chain reaction (PCR) can be used to amplify the HCRTR2 gene (and, if necessary, the flanking sequences) in the test sample of genomic DNA from the test individual. RFLP analysis is conducted as described (see Current Protocols in Molecular Biology, supra). The digestion pattern of the relevant DNA fragment indicates the presence or absence of the mutation in the HCRTR2 gene, and therefore indicates the presence or absence of narcolepsy. [0034]
• Sequence analysis can also be used to detect specific mutations in the HCRTR2 gene. A test sample of DNA is obtained from the test individual. PCR can be used to amplify the gene, and/or its flanking sequences. The sequence of the HCRTR2 gene, or a fragment of the gene is determined, using standard methods. The sequence of the gene (or gene fragment) is compared with the nucleic acid sequence of the gene, as described above. The presence of a mutation in the HCRTR2 gene indicates that the individual has narcolepsy. [0035]
• Allele-specific oligonucleotides can also be used to detect the presence of a mutation in the HCRTR2 gene, through the use of dot-blot hybridization of amplified proteins with allele-specific oligonucleotide (ASO) probes (see, for example, Saiki, R. et al., (1986), [0036] Nature (London) 324:163-166). An “allele-specific oligonucleotide” (also referred to herein as an “allele-specific oligonucleotide probe”) is an oligonucleotide of approximately 10-50 base pairs, preferably approximately 15-30 base pairs, that specifically hybridizes to the HCRTR2 gene, and that contains a mutation associated with narcolepsy. An allele-specific oligonucleotide probe that is specific for particular mutation in the HCRTR2 gene can be prepared, using standard methods (see Current Protocols in Molecular Biology, supra). To identify mutations in the gene that are associated with narcolepsy, a test sample of DNA is obtained from the individual. PCR can be used to amplify all or a fragment of the HCRTR2 gene, and its flanking sequences. The DNA containing the amplified HCRTR2 gene (or fragment of the gene) is dot-blotted, using standard methods (see Current Protocols in Molecular Biology, supra), and the blot is contacted with the oligonucleotide probe. The presence of specific hybridization of the probe to the amplified HCRTR2 gene is then detected. Specific hybridization of an allele-specific oligonucleotide probe to DNA from the individual is indicative of a mutation in the HCRTR2 gene, and is therefore indicative of narcolepsy.
• Other methods of nucleic acid analysis can be used to detect mutations in the HCRTR2 gene, for the diagnosis of narcolepsy. Representative methods include direct manual sequencing; automated fluorescent sequencing; single-stranded conformation polymorphism assays (SSCA); clamped denaturing gel electrophoresis (CDGE) heteoduplex analysis; chemical mismatch cleavage (CMC); RNase protection assays; use of proteins which recognize nucleotide mismatches, such as [0037] E. coli mutS protein; allele-specific PCR, and other methods.
PHARMACEUTICAL COMPOSITIONS
• The present invention also pertains to pharmaceutical compositions comprising nucleic acids described herein, particularly nucleic acids containing the HCRTR2 gene described herein. For instance, a nucleotide or nucleic acid construct (vector) comprising a nucleotide of the present invention can be formulated with a physiologically acceptable carrier or excipient to prepare a pharmaceutical composition. The carrier and composition can be sterile. The formulation should suit the mode of administration. [0038]
• Suitable pharmaceutically acceptable carriers include but are not limited to water, salt solutions (e.g., NaCl), saline, buffered saline, alcohols, glycerol, ethanol, gum arabic, vegetable oils, benzyl alcohols, polyethylene glycols, gelatin, carbohydrates such as lactose, amylose or starch, dextrose, magnesium stearate, talc, silicic acid, viscous paraffin, perfume oil, fatty acid esters, hydroxymethylcellulose, polyvinyl pyrolidone, etc., as well as combinations thereof. The pharmaceutical preparations can, if desired, be mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure, buffers, coloring, flavoring and/or aromatic substances and the like which do not deleteriously react with the active compounds. [0039]
• The composition, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. The composition can be a liquid solution, suspension, emulsion, tablet, pill, capsule, sustained release formulation, or powder. The composition can be formulated as a suppository, with traditional binders and carriers such as triglycerides. Oral formulation can include standard carriers such as pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, polyvinyl pyrollidone, sodium saccharine, cellulose, magnesium carbonate, etc. [0040]
• Methods of introduction of these compositions include, but are not limited to, intradermal, intramuscular, intraperitoneal, intraocular, intravenous, subcutaneous, oral and intranasal. Other suitable methods of introduction can also include gene therapy (as described below), rechargeable or biodegradable devices, particle acceleration devises (“gene guns”) and slow release polymeric devices. The pharmaceutical compositions of this invention can also be administered as part of a combinatorial therapy with other agents. [0041]
• The composition can be formulated in accordance with the routine procedures as a pharmaceutical composition adapted for administration to human beings. For example, compositions for intravenous administration typically are solutions in sterile isotonic aqueous buffer. Where necessary, the composition may also include a solubilizing agent and a local anesthetic to ease pain at the site of the injection. Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampoule or sachette indicating the quantity of active agent. Where the composition is to be administered by infusion, it can be dispensed with an infusion bottle containing sterile pharmaceutical grade water, saline or dextrose/water. Where the composition is administered by injection, an ampoule of sterile water for injection or saline can be provided so that the ingredients may be mixed prior to administration. [0042]
• For topical application, nonsprayable forms, viscous to semi-solid or solid forms comprising a carrier compatible with topical application and having a dynamic viscosity preferably greater than water, can be employed. Suitable formulations include but are not limited to solutions, suspensions, emulsions, creams, ointments, powders, enemas, lotions, sols, liniments, salves, aerosols, etc., which are, if desired, sterilized or mixed with auxiliary agents, e.g., preservatives, stabilizers, wetting agents, buffers or salts for influencing osmotic pressure, etc. The agent may be incorporated into a cosmetic formulation. For topical application, also suitable are sprayable aerosol preparations wherein the active ingredient, preferably in combination with a solid or liquid inert carrier material, is packaged in a squeeze bottle or in admixture with a pressurized volatile, normally gaseous propellant, e.g., pressurized air. [0043]
• Agents described herein can be formulated as neutral or salt forms. Pharmaceutically acceptable salts include those formed with free amino groups such as those derived from hydrochloric, phosphoric, acetic, oxalic, tartaric acids, etc., and those formed with free carboxyl groups such as those derived from sodium, potassium, ammonium, calcium, ferric hydroxides, isopropylamine, triethylamine, 2-ethylamino ethanol, histidine, procaine, etc. [0044]
• The agents are administered in a therapeutically effective amount. The amount of agents which will be therapeutically effective in the treatment of narcolepsy can be determined by standard clinical techniques. In addition, in vitro or in vivo assays may optionally be employed to help identify optimal dosage ranges. The precise dose to be employed in the formulation will also depend on the route of administration, and the seriousness of the disease or disorder, and should be decided according to the judgment of a practitioner and each patient's circumstances. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems. [0045]
• The invention also provides a pharmaceutical pack or kit comprising one or more containers filled with one or more of the ingredients of the pharmaceutical compositions of the invention. Optionally associated with such container(s) can be a notice in the form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceuticals or biological products, which notice reflects approval by the agency of manufacture, use of sale for human administration. The pack or kit can be labeled with information regarding mode of administration, sequence of drug administration (e.g., separately, sequentially or concurrently), or the like. The pack or kit may also include means for reminding the patient to take the therapy. The pack or kit can be a single unit dosage of the combination therapy or it can be a plurality of unit dosages. In particular, the agents can be separated, mixed together in any combination, present in a single vial or tablet. Agents assembled in a blister pack or other dispensing means is preferred. For the purpose of this invention, unit dosage is intended to mean a dosage that is dependent on the individual pharmacodynamics of each agent and administered in FDA approved dosages in standard time courses. [0046]
METHODS OF THERAPY
• The present invention also pertains to methods of therapy for narcolepsy, utilizing the pharmaceutical compositions comprising nucleic acids, as described herein. The therapy is designed to replace/supplement activity of the hypocretin(orexin) [0047] receptor 2 in an individual, such as by administering a nucleic acid comprising the HCRTR2 gene or a derivative or active fragment thereof. In one embodiment of the invention, a nucleic acid of the invention is used in the treatment of narcolepsy. The term, “treatment” as used herein, refers not only to ameliorating symptoms associated with the disease, but also preventing or delaying the onset of the disease, and also lessening the severity or frequency of symptoms of the disease. In this embodiment, a nucleic acid of the invention (e.g., the HCRTR2 gene (SEQ ID NO: 1)) can be used, either alone or in a pharmaceutical composition as described above. For example, the HCRTR2 gene, either by itself or included within a vector, can be introduced into cells (either in vitro or in vivo) such that the cells produce native HCRTR2 receptor. If necessary, cells that have been transformed with the gene or can be introduced (or re-introduced) into an individual affected with the disease. Thus, cells which, in nature, lack native HCRTR2 expression and activity, or have mutant HCRTR2 expression and activity, can be engineered to express HCRTR2 receptors (or, for example, an active fragment of the HCRTR2 receptor). In a preferred embodiment, nucleic acid comprising the HCRTR2 gene, can be introduced into an expression vector, such as a viral vector, and the vector can be introduced into appropriate cells which lack native HCRTR2 expression in an animal. In such methods, a cell population can be engineered to inducibly or constitutively express active HCRTR2 receptor. Other gene transfer systems, including viral and nonviral transfer systems, can be used. Alternatively, nonviral gene transfer methods, such as calcium phosphate coprecipitation, mechanical techniques (e.g., microinjection); membrane fusion-mediated transfer via liposomes; or direct DNA uptake, can also be used.
• The nucleic acids and/or vectors are administered in a therapeutically effective amount (i.e., an amount that is sufficient to treat the disease, such as by ameliorating symptoms associated with the disease, preventing or delaying the onset of the disease, and/or also lessening the severity or frequency of symptoms of the disease). The amount which will be therapeutically effective in the treatment of a particular disorder or condition will depend on the nature of the disorder or condition, and can be determined by standard clinical techniques. In addition, in vitro or in vivo assays may optionally be employed to help identify optimal dosage ranges. The precise dose to be employed in the formulation will also depend on the route of administration, and the seriousness of the disease or disorder, and should be decided according to the judgment of a practitioner and each patient's circumstances. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems. [0048]
• The following Examples are offered for the purpose of illustrating the present invention and are not to be construed to limit the scope of this invention. The teachings of all references cited herein are hereby incorporated herein by reference. [0049]
EXAMPLES Example 1 Identification of the Human Narcolepsy Gene
• A human BAC library (RPCI11 human male BAC library) was used. Twenty primers, designed from the mRNA sequence of the HCRTR2 receptor, were employed to identify clones of interest. They are set forth in Table 1. [0050]

  TABLE 1
  Primers Used for Hybridization

  #	Name	Primer Sequence	SEQ ID NO:

  1	HCRTR2-1-F	TACTACTACTAGGCCACGCG	3
  2	HCRTR2-1-R	ACACCAGGAGGAGAAAGCTAC	4
  3	HCRTR2-2-F	ATCGCCTGTAAAGACAGCAAAG	5
  4	HCRTR2-2-R	AAAGTTACTGAGCCAATGCCTC	6
  5	HCRTR2-3-F	GAGAGGAGCTTGCAGCATTG	7
  6	HCRTR2-3-R	AGGAATTCCTCGTCGTCATAGT	8
  7	HCRTR2-4-F	GAAGAACCACCACATGAGGAC	9
  8	HCRTR2-4-R	ATCACTTTGCAAAGGGACTGTC	10
  9	HCRTR2-5-F	GTATGCAATCTGTCACCCTTTG	11
  10	HCRTR2-5-R	AATGCAGGAGACAATCCAGATG	12
  11	HCRTR2-6-F	CAGGCTTAGCCAATAAAACCAC	13
  12	HCRTR2-6-R	GATAAGCCAACACCATGAGACA	14
  13	HCRTR2-7-F	ACAGATCCCTGGAACATCATCT	15
  14	HCRTR2-7-R	CTCGGATCTGCTTTATTTCAGC	16
  15	HCRTR2-8-F	CCAATTAGCATCCTCAATGTGC	17
  16	HCRTR2-8-R	GTGTGAAAAGGTAAACCAGGCA	18
  17	HCRTR2-9-F	CTCAGTGGAAAATTTCGAGAGG	19
  18	HCRTR2-9-R	GTTGCTGATTTGAGTGGTCAAG		20
  19	HCRTR2-10-F	CTTTCTGAGCAAGTTGTGCTCA	21
  20	HCRTR2-10-R	TACCAGTTTTGAAGTGGTCCTG	22

• Initial Study with Large Membranes [0051]
• Four out of 5 membranes having the whole BAC library, containing a total of approximately 160,000 BAC clones representing an approximately 10-fold coverage of the human genome, were used in hybridization studies with these primers. Hybridization was performed with a pool of all 20 primers described in Table 1. [0052]
• 5′ End Labeling for Big Membranes [0053]
• Oligonucleotides were labeled at the 5′ end before hybridization, using fresh (less than one month old) [γ[0054] ³²P]ATP (6000 Ci/mmole; 10 μCi/μl). The following protocol is adjusted for 4 membranes in 2 bottles, containing 2 membranes/30 ml of rapid hyb. Each. Briefly, a labeling mixture was made of DNA (8 pmol/μl) (10.0 μl of the primer pool), 10× buffer (12.0 μl), T4 PNK (10 μ/μl) (6.0 μl), [γ³²P]ATP (30.0 μl, or 600 μCi), and water (62.0 μl) for a final volume of 120 μl. 20 μl of labeling mixture was used per 10 ml rapid hybridization reaction. Incubation of the labeling mixture was for 2 hours at 37° C., followed by transfer to ice, spinning down, and mixing with the rapid hybridization solution. The membranes were prehybridized at 42° C. before the labeling mix was added. Sixty μl of the labeling mix was added to each of 2 big bottles containing 2 membranes and 30 ml of rapid hybridization solution.
• Hybridization and Washing [0055]
• The membranes were hybridized at 42° C. overnight. After overnight, membranes were washed with 6×SSC, 0.1% SDS at room temperature; washed with 6×SSC, 0.1% SDS at 55° C. in a shaking waterbath, repeated until the radioactivity of membranes was lower than 6k using 1× sensitivity; and washed with 6×SSC to remove the SDS. The washed membranes were put in a cassette for overnight exposure at −80° C. with a MR single emulsion film. Positive clones were identified and gridded on small membranes. [0056]
• Study of Positive Clones with Small Membranes [0057]
• After growing the positively-identified clones on several small membranes (to get several copies of membranes containing the same clones), and washing the membranes, hybridization was performed using pairs of primers, instead of a total pool of primers as before. The total number of hybridizations was nine, using different primers against identical copies of membranes containing all positive clones from the first hybridization. The primer pairs are set forth in Table 2; primer numbers indicate the primers shown in Table 1. [0058]

  TABLE 2
  Primer Pairs Used for Hybridization

  	Reaction number	Primers Used
  	1	1 and 2
  	2	3 and 4
  	3	5 and 6
  	4	7 and 8
  	5	9 and 10
  	6	11 and 12
  	7	13 and 14
  	8	15 and 16
  	9	17 and 18

• 5′ End Labeling for Small Membranes [0059]
• Oligonucleotides were labeled at the 5′ end before hybridization, using fresh [γ[0060] ³²P]ATP (5000 Ci/mmole; 10 μCi/μl). Briefly, a labeling mixture was made of DNA (8 pmol/μl) (1.5 μl), 10× buffer (2.0 μl), T4 PNK (10 μ/μl) (1.0 μl), [γ³²P]ATP (3.0 μl), and water (12.5 μl) for a final volume of 20 μl. Incubation of the labeling mixture was for 2.5 hours at 37° C., followed by transfer to ice, spinning down, and mixing with the rapid hybridization solution. Membranes were pre-wetted in 6×SSC, rolled in a pipette, and excess liquid drained prior to placing the membrane in the tube. Fifty ml Falcon (polypropylene) tubes were used as container for the hybridization. The membranes were prehybridized at 42° C. before 20 μl of labeling mix was added to each tube.
• Hybridization and Washing [0061]
• The membranes were hybridized at 42° C. overnight. After overnight, membranes were washed as described above. Four clones which were positive for primers designed using the 5′ and 3′ end of the mRNA were identified. Clone 403B19 was used to characterize the gene. [0062]
• Sequencing of Narcolepsy Gene in Clone 403B 19 [0063]
• Shotgun sequencing was used to obtain the gene sequence. [0064]
• Preparation of DNA Samples [0065]
• BAC DNA was isolated using the Plasmix kit from TALENT-VH Bio Limited. Thirty μg of isolated DNA was fragmented by nebulization: a nebulizer (IPI Medical Products, Inc., no. 4207) was modified by removing the plastic cylinder drip ring, cutting off the outer rim of the cylinder, inverting it and placing it back into the nebulizer; the large hole in the top cover (where the mouth piece was attached) was sealed with a plastic stopper; the small hole was connected to a ¼ inch length of Tycon tubing (connected to a compressed air source). A DNA sample was prepared containing 30 μg DNA, 10×TM buffer (200 μl), sterile glycerol (1 ml), and sterile dd water (q.s.) for a total volume of 2 ml. The DNA sample was nebulized in an ice-water bath for 2 minutes and 40 seconds (pressure bar reading 0.5). The sample was then briefly centrifuged at 2500 rpm to collect the DNA; the entire unit was placed in the rotor bucked of a table top centrifuge (Beckman GPR tabletop centrifuge) fitted with pieces of Styrofoam to cushion the nebulizer. The sample was then distributed into four 1.5 ml microcentrifuge tubes and ethanol precipitated. The Dried DNA pellet was resuspended in 35 μl of 1×TM buffer prior to proceeding with fragment end-repair. [0066]
• Fragment End Repair, Size Selection and Phosphorylation [0067]
• The DNA was resuspended in 27 μl of 1×TM buffer. The following materials were added: 10×kinase buffer (5 μl), 10 mM rATP (5 μl), 0.25 mM dNTPs (7 μl), T4 polynucleotide kinase (1 μl (3 U/μl)), Klenow DNA polymerase (2 μl (5 U/μl)), T4 DNA polymerase (1 μl (3 U/μl)), for a total volume of 48 μl. The mixture was incubated at 37° C. for 30 minutes, and then 5 μl of agarose gel loading dye was added. The mixture was then applied to separate wells of a 1% low melting temperature agarose gel and electrophoresed for 30-60 minutes at 100-120 mA. The DNA was then eluted from each sample lane, extracted from the agarose using Ultrafree-DA columns (Millipore) and then cleaned with Microcon-100 columns (Amicon), precipitated in ethanol, and resuspended in 10 μl of 10:0.1 TE buffer. [0068]
• Ligation [0069]
• EcoRV-linearized, CIAP-dephosphorylated Bluescript vector was used as a cloning vector. The following reagents were combined in a microcentrifuge tube, and incubated overnight at 4° C.: DNA fragments (100-1000 ng), cloning vector (2 μl (10 ng/μl)), 10× ligation buffer (1 μl), T4 DNA ligase (NEB 202L) (1 μl (400 U/μl)), sterile dd water (q.s.), for a total of 10 μl. [0070]
• Transformation of Ligated Products [0071]
• The ligation products were diluted 1:5 with dd water and used to transform electrocompetent TOP 10F cells (Invitrogen) using GenePulser II (Biorad; voltage, 2.5 W, resistance 100 ohm). Transformants were plated on LB plates with 50 μl of 4% X-GAL and 50 μl of 4% IPTG, and ampicillin. Transformants were grown overnight at 37° C., white colonies were picked, grown in a culture of 3 ml LB liquid media plus 200 μg/μl ampicillin for 16-20 hours with shaking. DNA was isolated from the liquid cultures using Autogen 740 Automatic Plasmid Isolation System. [0072]
• Cycle Sequencing of Isolated Plasmid DNA [0073]
• Isolated plasmids were then sequenced using the M13 primers: M13-forward (SEQ ID NO:23) TGTAAAACGACGGCCAG; and M13-reverse (SEQ ID NO:24) CAGGAAACAGCTATGAC. For the sequencing reaction, 2.5 μl plasmid template was mixed with 4 μl Big Dye Ready reaction mix (ABI), 1 μl of 8 pM M13 primer, and 2.5 μl dd water. For cycle sequencing, 25 cycles of 96° C. for 10 seconds, 50° C. for 5 seconds, and 60 ° C. for 4 minutes were performed, followed by holding at 4° C. The cycle sequencing reaction products were cleaned by spinning through Sephadex G-50 columns. The eluted cycle sequencing products were then dissolved in 3 μl formamide/dye and 1.5 μl of sample was loaded on ABI 377 automated sequencers. The data was analyzed using Phred and Phrap, and viewed in Consed viewer. [0074]
• While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. [0075]
• 1 24 1 168575 DNA Homo Sapiens CDS (21181)...(21403) CDS (95252)...(95430) CDS (101753)...(101996) CDS (110324)...(110439) CDS (124058)...(124278) CDS (127009)...(127130) CDS (128910)...(129139) 1 cgacttgatt ttattttttg catatggata tccagttttc acagcactgc ttgttaccct 60 cagcaaagaa cagttgtctg taaattcatg ggtttatgtc taggctctct gttctgttct 120 attggtcaac atatggtcat atatcactta actgcaggga agggatacat tctgagaaat 180 gcattattac atgatttcat cattgtgcaa acactataga gtgtagttac agaaacctag 240 tatctctagc tgtgttctta tgattcaaat ttgctttggt catttgagat ccatactggt 300 ggagtctaat tattcaaaac tagggaaaac agacaaacag aaaaaactaa gaccaagtta 360 gcagaagaaa gacaataaca aaggttagat caaaaataaa taatatagag aatgaaaaaa 420 ttagaaaaag tggacaaaac tacaatgtac ttttttgaaa agacaaacaa aattaacaaa 480 cccttacctt gactaaaaaa agagactcaa ataaataaaa ttggaaatga gacaggagac 540 attacaattg atgttaacaa aaagatcata aggtactatt atgaacaact atacaccaat 600 aaattggaca acctagaaaa aaaatggata aattcctaga aatacacagt ctatcaaact 660 gaaacaagaa gaaatagaaa gcctgaacat accagtaaca accaaggaga ctgagtaaat 720 aatcaaaaac ctcccaagaa gaagagtcta ggaccagaag tcttcacaaa tgaattctac 780 caaacattta aagtattaat gccaatcatt cattcttata ctcttccaaa aagaaagagg 840 gaatattttc aaactcattt tatgaggcca gcattattct gataccaaaa ctacgcaaaa 900 atactacaag aacataaaaa ctacaaatgt gggaattatc atgtatacat atgcaaaaat 960 cctcagtaaa atcctagcaa actaaattca acagtacatt aaaaagatca tatagcatga 1020 ccagtgaaat ttctccttag gacgcaagga taagtcaaca tataaaattg aatgtgatat 1080 accactttaa caaaatgaag gataaaaatc atatgatcat ctgaatagat gcagaaaaag 1140 catataacaa actttgacgt tgttgagaaa ttgaaagctt ttctctaaga tcaagaacaa 1200 agcaaggatg cccattcttg cttctattca gcatagtgct tgaagtccta gtctggacaa 1260 ttgggcaaaa ataaataaat aaataaatag ataaataaat aaataaatat aaataaataa 1320 ataaaatcca ccaaattgga aaggaagaag tgaaattacc tctgtttgta gatgagctga 1380 tctcatgtgt agacaacctt aaagattcca caaaaacaaa caaacacaca aacaaacaaa 1440 atagctagag caaagaaatg aattcagtac agttgcagaa tgcaaaatca gtatacaaaa 1500 agtacttgta attctatata atagcaacaa actatttcat aaggaaatta aggaaacaat 1560 ccccattaca atagcatcat aaataataaa tcttaagaac aaatttaacc aaggaggtga 1620 aagacttgtg tactgaaaac tataaaatgc tgataaaaaa attaaagaag atacaataaa 1680 tggaagatat tccatgccat ggtttggaag aattaatatt gctaaatgta catactaccc 1740 aaaacaacct gtagagtcaa tgcaatccct atcaaaatac caatattttt ttttttacag 1800 aaatgaaaac acaatcttaa cactatttaa accaattaaa caaacctatg atttcaattt 1860 ggtcaaatgt gttagaatgg atttcctttt attgttttga acttgtctct tccaaatttc 1920 aaagcctggt tcctaatttt tacttgaaat accaaataac aaacccactt aatgagctct 1980 gagccagttt tagtagccaa acttgtattt aaatagtgtg ttacatattt gcacaaaaag 2040 ccaacggagt ctaaatcaac actaattcac atcattacta gcaatctaaa acatcagatg 2100 ataattttgc tgttgtcttt caggcaagat attcaaccat tggtattaaa tgttttatat 2160 gaatgtgcgg tgttttattt cagaaacact tctctgaatt cccaaggcct aagagctatt 2220 catcatagag gtttgtggag gcggtagtta gacattttct acatgcataa tgttaattca 2280 ttcaaacatt atagaaaaaa agtttgtaaa gaagttaatt ttcaaggtga caaaaaaatc 2340 agattgaatc atgtttattt tatttcaatt taaactcgtt ggctatctta ggaaattcac 2400 attgtttttg aagaatatat gaacaaagtt tgattcatct tatctatata agcatgagag 2460 aaatacctag atgagagtga aaaatgacta attttgtgac cattgttata tcatagatta 2520 acttgttctc ttctacttct aagctgtgtg atcttgaaaa gtcatctaaa cttcaggtac 2580 catcctcact tgcaaaatga ggggaaaaac cccagcacct ttaatatggt gttatgtgga 2640 tgaaataagt taatatatat taagtgctta ggtttcatgc actttctata tagtattaat 2700 aatattattg ttacattatt atagttacat tattattttt attaatatta ttggaacatg 2760 aatggaattg ttgtggctca ttttaaagat gctgcaatgg agaccaagag aaattaagta 2820 taataatcct agttaaggta cagccatttc taattacatt ttccaactgc tgcttttact 2880 cctagcactc acaccaattc ttctcataat ctaataaata ctgaaattta aaacttataa 2940 agaacacata ataatcttat ttaattatca caacaatttc tgtggagtta ctattaatcc 3000 agagatgaag aatctaaaac tctaaattat caagcaacta ttccagcttt aaacaacagt 3060 aaaactggaa ttaaaactag agtttcttta tgaggccagt attactctta tactaaagca 3120 agacaactgt ctctctctca ctctctcttt ctctctctct gagacacaca cacacacaca 3180 caagcacaca cacacacaca ccagatcaat ataacttatg gatgttgatg caaaaatttt 3240 caaaaaatta atagcaaatc gaatccagca gtattttaaa ggactataca ccatggacaa 3300 atggggttta ttcctgggat ataaagttgg ctaaacttaa tgaaaatcaa ccagtgcaat 3360 aaataatagt aattaaaaaa acataattat ctcactagat gtacaaaaaa tgacaagatc 3420 caacatgttt tcaatataaa agcattccac agactaggaa tagaagggaa cttcctcaac 3480 tttacaaaga acatctacaa cgaaaccaca gctaacatca tatttaatgg tggaagactg 3540 aaatctctga atattttccc ctaagatcag aaaaagacaa agaggtctac taattctatt 3600 caacattgga aagatagttc tagtcaatta atcattaaaa aaaggcattt agattagaaa 3660 ggaagtaaaa ttacctctgg cagatgacat aatcttatac atggagaact cctagagatt 3720 acatacacac tcacaactac cagagttaat aaatgggttc tacaaagttg caggatacaa 3780 tatcaattct caaaaaacac ttgtatttct atacactagc aaataactct gaaaatgaaa 3840 ataacaaaac aattccactt gcaagagcat caaaaaagca tgaaaatctt aggaaggaat 3900 ttaccaagaa tgtacaagtt ttatgtactg aaaaataaaa aatgtcatta aaaatagtta 3960 aagagaatct aagcacattg cagttttctg actccaggcc cgggctcttg gatggcatct 4020 ctggatccac tcaggaccag ggagaacttg ttgccctgaa gggaaggaca caagtctgac 4080 tggctttacc acctgctgat tgtagaagcc tagggccttc agggaacaca ggtggtagcc 4140 agatagcagt taccatgggc attaggcatg acccagtgct atgttggctt ctagtttgac 4200 ccagcacagc ccaagggtgg taaccacatg ggtgcttgtg tcacccctcc ttaagttcca 4260 ggcagccagc aaagagagag tgactctgtt tgggagaaag taagggaaga gaataaaagt 4320 ctctgttggt aatacaagga attcttccag atcttatcca agacctctat gaatctgcaa 4380 cagccaaagc attattagtt ttcaggtttc cccagtgcag atatgactgc aatgatcaaa 4440 aacttagatt ataacactca agtcccattt gatacctgaa aagctttcca agaaagatag 4500 gcacaaacaa gtttggactg ggaggactac aataaatacc taacttctca atgcccagaa 4560 actgatgaac atccacaagc tttaagacca tccaggaggt ggctggcaag atggctgaat 4620 aggaacagct ctggtctgca gctcccagtg agatcagtgc agaaggtggt ggtttctgca 4680 tttccaactg aggtacccag ctcctctcat tgggactggt tagatagtga gtgcagccca 4740 cagagggtga gccaaagctg gatggggtgt cacctcactg gggaagcaca aggggatggg 4800 gaactccctc ccctagccaa cggaatctgt gagggactgc catgagggat ggtgcattct 4860 ggtccagata ctatgctttt cccatgttct tcacaaccct caggccagga gattccctcg 4920 ggtgcctaca ccaccagggc cttgggtttc aagtacaaaa ctgggtggat ctttgggcag 4980 gcaccgagct agctgcagga gttatttttc ataccccagt ggtgcctgga atgccagtga 5040 gacagaacca ttcactctcc tggaaaggga gctgaagcca gggaacccag tggtctagct 5100 cggtggatcc cactcccatg gaggccagta agctaagatc cactggcttg aaattctcac 5160 tgccagtgca gcagtctgaa gtcaacctgg gatgcttgag cttggtggag agagggacgt 5220 ccaccattac tgaggtttga gtaagcagtt ttcccctcac agtgtaaaca aagccactgg 5280 gaagttaaag taggtggagc ccacgacagt tcggcaaagc cactatagcc agaatgcctc 5340 tctagattcc tcctgtctgg gcagggcttc tctgaaagaa aggcagcagc tgcggtcagg 5400 agcttataga tcaaactccc atctccctgg gacagggcac ctggggaaag gggcagctgt 5460 gggtgcagct tcagcagact taaatattgc cgcaagctga ctctgaagac agcaggggat 5520 ctcccagcac agcgctcgag ctctgctaag gggcagactg cctcctcaag tgggtctctg 5580 acccctgtgt ctccagactg ggagacaccg cacagcaagg gtcgacagac acctcataca 5640 ggagagctcc ggctggtatc tggtgggtgc ccctctggga caaagcttcg agaggaagga 5700 gcaggcagca atctttgcag tactgtagcc tctactggtg atacccaggc aaatagggtc 5760 tgacgttgac ctccagcaaa ctccagcaga ccttcagcag acgggcctga gtgtaagaag 5820 gaaaattaac aaacagaaag gaatagcatc aacatcaaaa aaacaaaaac aaaaacaaaa 5880 acaaaaacaa aaacagcaca tccgcacaaa aaccccatct gaaggtcacc aacaccaaat 5940 accaaaggta gataaatcca caaagatggg gaaaaaccag cacaaaaaag ctgaaaattc 6000 caaaaaacag aatacctctt ctcctccaaa ggatcacaat tcctcaccag caaggggaca 6060 aaactggaca gagaatgagt ttgatgaatt gacagaagta ggcttgaaaa ggtgggtaat 6120 aaactcctct gagctaaagg agcatgttct aacccaatgc aaggaagcta agaaccttga 6180 aaaatggtta gagtaattgc taactagaat aaccagttta gagaagagca taaatgacct 6240 gatggagctg aaaactatag cacaagaact tcgtgcagca tacacaggta tcaatatcca 6300 aatcgatcaa gcaaagaaaa gaatatcaga gattgaagat caacttaatg aaataaagtg 6360 tgaagaccag attagagaaa aaagaataaa aaggaatgaa caaagtctcc aagaaatatg 6420 ggaatatgtg aaaagactaa acctacattt gattagtgta cctgaaagtg acggggagaa 6480 aggaatcaag ttggaaaaca ttcttcagga tattatccag gagaacatcc acaacctagc 6540 aagacaggcc aacatttaaa ttcaggaaat acagagtaca tcacaaagat actcctcgag 6600 aaaaacaacc ccaagacaca taattgtcag atgcaccaag gttgaaatac aggaaaaaag 6660 ttaagggcag ccagagagaa aggtcgggtt acccacaaag ggaagcccat cagactaaca 6720 gtggatctcc ctgcagaaac cctacaagcc agaagagagt gaaggccaat attcaacatg 6780 ctttaagaaa agaattttca acccacaatt tcatatccag ccaaactatg cttcatagtg 6840 aaggagaaat aaaatccttt acagacaagc aaatgctgag aaattttgtc accaccaggc 6900 ctgccttaca agagctcccg aaggaagcac taaatatgaa aaggaaaaac cagtatcagc 6960 cactgcaaaa acatatgaaa ttgtaaagac catcaacact atgaagaaac tgcatcaact 7020 aatgggcaaa ataaccagct agcattataa tgacaggatc aaattcacac ataacgatat 7080 taaccttaaa tgtaataggc taactgcccc aattaagaga cacagactgg caaattggat 7140 agagagtcaa gacccaacag tgtgctgtat tcaggagtcc aattcatgtg caaagataca 7200 tataggctcg aaataaaggg atggaggaat atttactaag caaatggaaa gcaaaataaa 7260 gcggaggttg caatcctagt ctctgataaa atagacttca aaccaacaaa gatcaaaaga 7320 gacaacaaag ggcattacat aatgataaag ggatcaatgc aacaagaaca gctagctatc 7380 ctaaatatat atgcacccaa ttcaggagca cacaaattca tcaagcaagt tcttagagac 7440 ctatagagac ttagactccc acgtaataat agtgggagac tttaacaccc cactgtcaat 7500 attaaacaga tcaatgagac agaaaattaa caagtacatt caggacttga actcagctct 7560 ggaccaagca ggcctaatag acatctatag gactctccac cccaaataaa tagaatatac 7620 attattctca gcaccacatt gcacttattc taaaattgac cacatcattg gaagtaaaag 7680 actcctcagc aaatgccaaa gaactaaaat cataacaaac agtctctcag accacagtgc 7740 aatcaaataa gagctctgga ataagaaact cactcaaaac cgcacaacta catggaaact 7800 gaacaacctg ctgctgaatg actactgggt aaataatgaa attaaggcag aaataaataa 7860 gttacttgaa accaatgaga acaaagacac aacataccag aatctctggg acacagctaa 7920 agtagtgttt ggagggaaat tcatagcact aaatgcccac acgagaaagt gggaaagatc 7980 taaaatcaac accctaacat cacaatgaaa agaactagag aagcaaaggc aaacaaattc 8040 aaaagctagc agaagacaag aaataactaa gatgagagca gaactaagga gagagagaca 8100 cgaaaaaccc ttcataaatc aatgaatcca agagctgttt tttttgaaaa gattaacaaa 8160 atagatagat cactagccag actaatgaag aagaaaagag agaagaattg tatagacaca 8220 ataaaaaatg ataaagggga gatcatcact gatcccacag aaatacaaac taccatcaga 8280 gaatactata gacacctcta tgcaaataaa ctagaaaacc tagaagaaat ggataaattc 8340 ctggacacat acaccttccc aagactaaac caggaagaag tcaaatccct gaacagacca 8400 ataacaagtc ctgaaattga ggcagtaatt aatagcgttc caatgaaaaa aagcccagga 8460 ccagatggat tcacagccaa attctacaag aggtacaaat cagagctggt accattcctt 8520 ctgaaactat tccaaacaac agaaaaagaa agactcctcc ctaactcatt ttatgaggct 8580 ggcatcatcc tgataccaaa acctggcaga gacatacaca caaaaaagaa aatttcaggc 8640 taatatatcc ctgattaaca ccgacgcaaa aatcctcaat aaaatactgg caaaccaaat 8700 ccagcagcac atcaaaaagc ttatccacca cgatcaagtt ggcttcatac ctggcatgca 8760 aggcttgttc aacatacgaa aatcaataaa tgtaattcat cacaaaaaca gaaccaatga 8820 caaaaaccac atgattatct caatagatgc agaaaaggcc ttcaacaaaa tttaacagcc 8880 cttcatgcta aaaactctca ataagctagg tatcgatgca atgtatttta aaacaataag 8940 agctatttat gacaaaccca tacccaatat catactgaat gggcaaaagc tggaagcatt 9000 ccctttaaaa actggcacaa gacaaggatg ccctctctca ccactcctat tcaacatagt 9060 gttggaagtt ctggccaggg caatcaggca agagaaagaa atagaaggta ttcaaatagg 9120 aagagaagaa gtcaaattgt ctctgtttgt ggatgacatc attgtatatt tagaaaaccc 9180 cattgtctca gcccaaaatc tccttaagct gataagcaac ttcagcaaag tctcaggata 9240 caaaatcaat gtgcaaaaat cacaagcatt tctatacact aataatagac aaacagagag 9300 ccaaatcatg agtgaactcc cattcaaaat acctaggaat acaacttaca agggatgtga 9360 aggacctctt caaggagaac tacaaaccac tgctaaggaa ataaaagagg atacaaacaa 9420 atgcaaaaac attccatcct catggatagg aagaatcaat atcatgacaa tggccatact 9480 gcccaaaata atttatagac tcaatgctat gttcatcaag ctaccaccga atttcttcac 9540 agaattagta aaaaactggc caggctcagt ggctcacgct tgtaatccaa gcactttggg 9600 aggccaaggc aggaggatca agaggtcagg agattgagac catggtgaaa ccccgtctct 9660 actaaaaata caaaaaatta gccgggcgtg gtggcaggcg cctgtagtcc cagctacttg 9720 gagaggctga ggcaggagaa tggcgtgaac ccaggagacg gagcttgcaa tgagccaaga 9780 tcctgtcact gcactccagc ctgagtgaca gagcaagact ccgtctcaaa aaacaaacaa 9840 acaaacaaca aaaaaaaaaa aactacctta aatttcttat ggaactaaaa aagagcccat 9900 atagccaaaa caatcctaag caaaaagaac atagctggag gcatcatgct acctaacttc 9960 aaattatgct acaaggctac agtaaccaaa acagcatggt attggtatga aaacagatat 10020 atagaccaat ggaacagaac agaggcctca gaaataaccc cagacatcta caactctctg 10080 atttttgaca aacctgacaa aaacaagcaa tggggaaagg atttcctatt taataaatgt 10140 tgttgcgaaa actggctagc catatgcaga aaactgaaac gggactcctc ccttacacct 10200 tatacaaaaa ttaactcaag atggattaaa gacttaaacg taagacctaa aaaccataag 10260 aaccctagaa gaaaacctag gaaataccat tcaggccata ggcatgggca aacacttcat 10320 gtctaaaaca tcaaaagcaa tggcaagaaa atcccaaatt gacaaatggg atctaattaa 10380 actaaagagc ttctgcacag caaaagaaac tatcatcaga gtgaacaggc aacctataaa 10440 atgggagaaa atttttgcaa tctgtccatc tgataaaggg ctaatatcca gaatctacaa 10500 tgaactccaa caaatttaca agaaaaaaac aaccccatca aaaagtgggt gaaggatgtg 10560 aacagacacc tctcaaaaga agacatttat gtggccaaga aacatacaaa aaaaagctta 10620 tcatcactgg tcattggaga aatgcaaata aaaaccacag tgagatacca tctcactcca 10680 gttagaatgg cgatcattaa aaagtcagga aacaacagat gctggagagg atgtggagaa 10740 ataggaacgc ttttacactg ttggtgggag tgtaaattag ttcaaccatt gtggaagaca 10800 gtgtggtgat tcctcaagga tctagaacca gaaataccat ttgacctagc aatcccatta 10860 ctgggcatat acccaaagga ttataaatca ttctatgata aacacacatg cacatgtatg 10920 tttattgtgg cactattaac aatagcaaag acttggaacc aacccagatg tccatcaatg 10980 atagactaga ttaagaaaat gtggcacata tacaccatga aatactatgc agccataaaa 11040 aaggatgagt tcatgtcctt tgcagtgaca tgaatgaagc tggaaaccat cattctcagc 11100 aaactatcac aagatcagaa aaccaaacac cacatattct cactcataag tgggagttga 11160 acaatgagaa cacatggaca cagggagggg aacatcacac accagggcct gtcaggcagt 11220 ggggggctag gggagggata acattaggag aaatacataa tgtaggtgac aggttgatgg 11280 gtgcagcaaa ccaccgtggc acatgtatac ctatgtaaca aacctgcacg ttctgcacat 11340 gtatcccaga acttaaagta ttaaaaaaaa aagaccattt atgaaaacat gaccttacca 11400 aagaactata taagtcactg gagaccaatc ctggagtgac agaaatatgt gacctctcag 11460 atggagaatt caaaatagct gttgtgagga aattcaacaa aattcaagat gacatggcaa 11520 aggaattcag acttctatca gataaattca aaaaagaaga tgaaataatt tttttaaaaa 11580 ttcatgcaga aattttggag ctgaaaaatt caattgatat acaaaagaat gcatcttacc 11640 agcagaattg atcctgcaga agaaagaatt agtaaatttg aaaacactct atttgaaaat 11700 atacagtcag aggagacaaa agaagaaaat taaaaacaat gaagcatacc tacaggatct 11760 agaaaatagc ctcaaaagca taaatctaag agttactggc cttaaaaagg aaggagagag 11820 agagagagag tgggataggg gtagaaagtt tattcaaagg gataacaata gagtatcagt 11880 attcaaatac aaggttatgg aacaccattc agatttaacc caaagaagac tacctcaaga 11940 catttaataa ctgaactctc attcaatggg aaaagtaaag tcctttcaat aaaggtgttg 12000 ggataattgg gtatgcaaaa aatgaatttg gatacctttc ttgtgtcata tacataaaac 12060 cccaaaatag attaaagacc taagtataag agctaaaact atgaaactct tagaaagaaa 12120 cacagtaaat ttttgtgacc tttgattagg caatgatttc ttaaatatga taaaatatgg 12180 taaaagcaac aaaagaaaac atgaataaat tggatcttat caaaatttaa aacttttttg 12240 catcgtagaa tactatcaag agtatgaaaa gaaaacctac aaaataggag aacatgtttg 12300 gaaatcatgt atttgttaag ggattagtat acagaatata tatatatata tatatatata 12360 tatatatata tatatatata tactcttaca cctcaactat aaagagacga ataacccaat 12420 ctaaaaaaat aggcaataaa tagctattag ttctccaaag tacatacaca aatgaccaac 12480 aagttcatca aaagatgctc atcatcttta ctcaggaggc aaatacagat taatattaca 12540 atgatattag acatggattt gtcatataca gactttatta agttagattc cctctatgcc 12600 taatttgttg agagttttta tcatgaagag atgttgcatt ttgtcaaatg ccttttctgt 12660 gtcttttgag atgatcatat ggttttcgtc ctttattttg ctgatatgat gtaccacatt 12720 tattgatttg catttattga atcatccttc cacccctggg ataaatccca cttgatcatg 12780 gtgtattatc tttttgatgt tttttggatt cactttgctg atattttgtt gaggatttct 12840 gcatctataa tcattaagga tattggcctg tagttttctg tttttatgtt gtattctagt 12900 ctgattttgg tatcagggta atgctgttct tgttgagcgt gtcaggaagt ccaaaagact 12960 tcttctttag tgttttggaa tagtttgaga attgttagtt tttttttttt ataagtttgg 13020 tagaattcag cagtaaagcc atccagttct gggcttttct ttgttaagag acttaaaaca 13080 cacacaacgc acacacaaaa tgaaatatca ctttccaccc attataattt acaaagtgga 13140 aaataactcg tgttgataag aatgtggaaa ccttgaaacc ttcatgcatt gccagtggta 13200 atgtgaaaga atcttgccat tgtggaaaac aatttgtcag ttcctcaaac agttcaacat 13260 agagttactg tatgaaataa ttcaactccc aggcatgcac ccaagagcat tgaaaacata 13320 agtacacaca aaaacttgta caagaacagt cagatcagta ttatatataa ttggcaaaaa 13380 atggaaacaa tccaaatatt catcaactgc tgaatagata aaatgtggca tatccatata 13440 attaaatact attcagccac aaaaataata aagtacggat agacactaaa acatggaaga 13500 accttgaaaa tattaagcta agtgaaagac ataagacaca aaacccaaca tttaaaggaa 13560 atttccagaa ttgtcagatc cactgaagaa gaaacttgag tgtttgccag catgtgggag 13620 gagaggaaaa tcagtagtta tgaggtttct ggaattagta gtgctgatgg tgacacaaca 13680 ttgtgaatat actataaacc actaaatgat acctctcaaa atggttaaaa cattactgtt 13740 gtgttatgtg aattttacct caattagaaa agaaaaaaat cttatcaata acaaagagaa 13800 atttccacac aaggtgggat cgcttccaca gtgctactca atgcagttta gcgattgcat 13860 ttgtattgga gtaaaagcat gtcacattgc ttttaacatt ggagtccaat acataaacct 13920 ctttcaccat aactatatgg agttcattgt atgtatattt attaaaatgg aattaagatg 13980 aatttcacaa cacaatggat catttttttt ttcatgtgga aaatcagaac acatgcctta 14040 atggttacat gccccacctg ctgctcacct aaaagtaaat ttcctctaac tcagacaaat 14100 atgttatttt caaggaaaag aagcccagag aactgagatc cagaagaaat aacatgtatt 14160 gaaagcacac agaagtattt caatgaactc aaacccaaga ttgtagaaaa ctctcatgtg 14220 cccctgggac tgatgtttga aaatacacat attttgctcc tactctttcc ttccccagat 14280 cccacccttc agagcacccg acgataatgg atagtttcta gcagggtgtc tggaatgggc 14340 aagtaccccc aaagttatag tttgtactgc aagacttgaa cccactcttt ttctgccctc 14400 tattattatt tttgcatttt aaccatttat tattttgaaa agaaaagaga atttttagaa 14460 tatggaaaga ggaagtgaat taataaaata gcacacccta catagagact gctaatccat 14520 ctccagtcta aagatttagt aataggcaag aatatacata tccaggaatt tccttggtgt 14580 tacataaaca aaggcggcac atatgtatat ttttcacaaa atattcactg tttgaagaag 14640 gaattactcc cttcaattga gttcaggcct gatcaacaag tagtgattgg ccaacagcta 14700 aatgcaaagt gcatgctaag tctggggata caaagatgaa tgagaaaaca tttatgccct 14760 taggagaaaa acaaatatct ttatctcaga gaatagagaa ggagattgat tctctttggg 14820 ggagatgtca tcctgaagag tataacaagt tcccctataa ttctactttt cagtactgtt 14880 taaaatacaa ctggattttt ttaaatatgt aaaatttata taattttaca aatgtctttg 14940 ttaagaatta aaactatcat tagtaaagga cacagctgga aaattgaaaa cattttggtt 15000 ctctactgtg gaaacagaat agagtaacag caaaaagcgt atttctggaa ttggaccctg 15060 acaactctgc ttaaacactc caccactttc tagctatatg accttgggta agttacttaa 15120 cttctttgtg tgtcagtttc ttcatttgta aaattggaat aatagatgct ttttttgaga 15180 cagtgtctca ttctgttgcc caggctggag tgcagtggcg tgaccacagc tcactgcagc 15240 ctcaacctcc tgagttcaag tgattctcca acttgagcct cccagatagc taggaccaca 15300 gacacatgcc accatgcctg ggtaattttt tttttaagtt tttcatagaa atagtgtctc 15360 actaagttgc ccaacctgga aaattggaat aataattcat aaaatcttcc tcctagattt 15420 gtgaagatca attgagttaa tgtatgtaac gtacttggca cagagcttgg cccatgtaat 15480 ctctcaatga gtgctaacat tacttgtctc acaaaaagtt acttacttcc gtctggcacc 15540 aactccctct ctcacttccc acaatctggt taccattcat tcttcagttc tcagcttaaa 15600 caatgtcttt tccatatggt ttcattgacg ccactttggg aaaatagatg tctcttctgc 15660 ttgcattttc agaccttttt aggtgtatac cttagggcat ttgctttact gaccaaaatt 15720 atttgccggc tactctgtgc ttttcatgac acactgaata agacaggaag agtgtttatc 15780 tatgctcaac ataagatagg catataatgg aagcttcgta tatatttgtt gaataaaaaa 15840 cataagggga aaatatcaga tctaataatg caggacagga ggcaagatgg aacggagaga 15900 accttgtctg agaagagaca taattaaaac agggcatggg aggtaataga aagattggag 15960 gaaaaagaga cagagagaca gaaatgtttg tggtaatttg tgacaagtag ctttgattgt 16020 tcatggccta atcttttagg gcatgaggtt atttcattct ctgtagccca ccgagagtgc 16080 gtacagtgac acatgttatg taagtcccct tttccctttt tataaatgtc tagaccccct 16140 gtgatttgag acttttctag aagaatttag ctgaagacca tattgttttt taaatgtagt 16200 atttggagcc tagaggtgcc agataacttc ctgcaaagct aatgcattta ttttgggaat 16260 atataagctc agtatcatca ttaccaacag tgctcagact tgattttatt ttcattccaa 16320 cagcaaagga aagaaagcaa cttctttcat gcttccatgc cactctgcat ctctctacct 16380 tcacagagtt tctcaataat ggcaacattt ccagttcacc aatggactga gagatcattg 16440 aggctagact agtcttatta atccttatac cccagctcct agccgaactc ctggacacac 16500 aatagatact cagatacatt tactgaaatg catatagaaa gttacacctg caaaaaagat 16560 gatctctcac caggaataag aaaatataat ctgggacagc ccatatatga gatctctaaa 16620 caacctacct ataaccacca agaaaaaaaa atacctgagt ttgagattta tttttccgtc 16680 tcatttttaa tatattccag ttagtgaaag agctaaaata aatgacaaga aaaatttaat 16740 ctaggtattt aaacagaatt attctgaatg ttgtgagcta catttctttt ttacctttta 16800 tttatacata gtatttgtat atacttatac aatatattta ttttgtatat ataaatatat 16860 tgtatttatt tatacatgta aatgtataat atatttattt atacatagta tttatatata 16920 catagtattt gtatatattt atagggtaca tgtaatattt tgttacacgc atagaatgtg 16980 taatggtcaa gccagaatat ttagagtatc cattacctta agtatttatt atttctctgt 17040 gctaggagca tgttaagtcc tctcttttag ctattttgaa atgtacattg atgttaacta 17100 tcattaacac agagtaattg atatgtatag caaataatat ttgcagtagg atatcacatg 17160 tttacttatt tatttattta tttattttta ttatacttta agttctaggg tacatgtgca 17220 caacgtgcag gtttgttaca tatgtatgca tgcgccatgt tggtgtgctg cacccattaa 17280 ctcctcattt acattaggta tatctcctaa tgctatccct cccccctccc ccaccccacg 17340 acaggttcca gtgtgtgatg ttccccttcc tgtgtccagg tgttctcatt gtttaattcc 17400 cacctatgag tgagaacata cggtgtttgg ttttttgtcc ttgcgatagt ttgctgagaa 17460 tcatggtttc cagcttcatc catgtctctg caaaggacat gaactcatcc tttttttggc 17520 tgcatagtat tccatggtgt atatgtgcca tattttctta atccagtcta tcattgttgg 17580 acatttgggt tggttccaag tctttgctat tgtgaatagt gccgcaataa acatatgtgt 17640 gcatgtgtct ttatagcagc atgatttata atcctttgtg tatataccca gtaatgggat 17700 ggctgggtca aatggtattt ctagttctag atccttgagg aattgccaca ctctcttcca 17760 caatgattga actagtttac actcccacca acagtgcaaa agtgttccta tttctccaca 17820 tcctctccag cacctgttgt ttcctgactt tttaatgatc gccattctaa ctggagtgag 17880 gcactggtct gaaaatatca attcatttaa ttcttttaac aaccttaagg ggatatcatg 17940 gtacaaattt agagctttct tttgtgtttg taaaatggat tgattccttt tccctacatc 18000 cagcagaaat atttgaattg aagagaagag taatacctaa gaactagaaa ttcctttctt 18060 atgtttcaaa agatatcaaa agatctaagg aagatattca catcaaaaat gagtattata 18120 atatttatta tctatggtgc acttgcaaaa aagaaaacaa gtaataatct gaagatttaa 18180 gtgaatattt tatgacattg gagtaccaca tatttagaag aaagcaccag agaaatcata 18240 gatagaagga aatggaatat ttgtaggatc aagataaata cagcttgtca taaaataaag 18300 caggtatcag gataaaatct tgaaaatatt ttcatttctc gttatttata acttcaattt 18360 actgtgatga ttaattgtag gtggaagatt tacgaagaga agactgaagt atagacaagt 18420 tgaagtgcca caaaatgaaa gctaatgaca ctgactactt aggaaatagc agactgggtc 18480 catatttata gattgtcaat gacaaggaat ttgcagatgt taatgaatat agatccgaac 18540 ttaagttgca acaacctttc ccactttgag atgaatagtg catggaagag taaaatgcag 18600 atgttaataa atcagaggaa gacatcgtgc cagagtataa agttgacaga tttatgccga 18660 tgaacttgaa caaagccaca gaaggcctac ttgtcaaatt tactggtgac aacaggtctg 18720 gagaaatggc taatgttttg gataatagca ttagaattta aggtctgttt aaacttcaaa 18780 ttaacagaat gaaattaata tatgcacata tcaattgggt cttttgctta tatatcatct 18840 cttaatagag cctttttgaa caatcatttc taatgtgacc tttgggattt tctactcatc 18900 atcacctcat cctgtttggt ttgcattata gcatctatcc cttcctaacg ttttccctat 18960 gtatttgtta gtttgttttt ttttaatcta actttactag aaagtaaaat gcatggaaac 19020 agcaacctgt ttaactttgt atcactaaga gtggaaaaat aaccctcagg aaatatttgg 19080 taaaataata aaatgcccat tgatgccctt ctcttaaaaa gaaatttaat tagtgcagat 19140 tggggaaata caacaatatt tctcataaaa tgtgatatct atacaataac agaagtacta 19200 tgtcccaaaa agtattctat aaatagaaga aagaacagat ggttttgctg ctgattaatc 19260 catttatctt tcgtaaatca tctaatttcc ccaggaacag cttcctcatc tattaaaggg 19320 ggttagtaat agctaagccc tcaggggttt aaaaatgcat atgaaataat tttataaacc 19380 ataaagcaca aaacaaatat gaaaaattat gattggagga gggggtgggg tagttaacta 19440 aatctcagtg taaaccacca atgtcttgtg tgtgttgaaa aaataattac atataaaaac 19500 tggttgcatc caaagaataa tgtacttttt gcactggcaa gactcaaacc atattattgt 19560 tacttcctcc cagttacata ttttgcaaga tattgacaat tgtctaaagg aagaccaaac 19620 agatgtaggt gggagctact gtcatttgaa caacattgaa aagaaaaata ctaaaaaaga 19680 aacatgaggg catataaagg agcgctgggg ctgtgatgtt tattttgaat ctgtgaagca 19740 ttgtcatgtg gaagatttat tctgtgtagc accaagatgc aaactaggaa ttagaggtaa 19800 aagtctcaaa aagacaaatc gtggcttgag accttggttt aatgtaagaa acagttttct 19860 cacccttaga gcactcccat aaggatggaa gtagtgaatt gtggtggtca cattcaagct 19920 agatggggac atgtcagcaa tgttatcagg aggcttctac tctgaagctg aagttcagac 19980 aagatttcca ggctcttccc aagtgcaaga ttgtaattac ttaaatgcaa tatttttacc 20040 atgtttatta agaataaaag gatcatgaat tcacattctg acaaatgcta gaatacttat 20100 tattagagac aaaaccagtg catgagagaa tggcaggtga catcagccct gaatcaatgg 20160 gaagaaagac ccaatgggat gtggtattta ccagagagag cacttctgct tagattgcta 20220 catcctacag tgaatgttta atatcattga gtatattggt ggtctgtcat gcttgacaac 20280 attaactatg atcatattta tgacacttgg cgtccttcaa gaatttgtag ctctatttca 20340 catgacactt aactatcgca aatacaaatt ccagctaaat agacccttca gtttaaaaac 20400 agtctcattc tcaaatttta aggagaaagt gaagacggag atgtcttaaa gactcggcaa 20460 gtactaagtt ggcaaatgtc aaatgttaaa ataagtttat attaaatgtt aaagtgtttg 20520 cctggaatga cttttccatt gtcctgcttg agaaacacag aggcacctcc ttattgcttt 20580 tatatttgct ttacaaagac aaatgtatca acatgctctg tattaattgt atgttgacat 20640 ttttgtcata tccacagact gatgcatgtc tgtgcatggt ttataataag tgcacgtaaa 20700 aatagagaaa ataagtagaa aaagagagag atttaactct caccccccac cccccaaaaa 20760 aacagattaa attagttttc attacttttt tttttttctt cagcttcagc tctccctcag 20820 cgagggagga ggctgtgggc tgcggactga gtgctggaat gaggagtaat tgagcttcag 20880 ctgagccgga cgtagctttc tcctcctggt gtcattgctg cagcctccag tgccgggtcc 20940 ctagttcctc agctgcctat cttcccggtg caacatcgcc tgtaaagaca gcaaagccac 21000 cgcagaagtt gcccggcaga agactccgga ggcattggct cagtaacttt tcacgtcatt 21060 ttctgctcgg gagccccttc tagcctctcc gcgcagcctt tcccaccgca aatcaccagt 21120 gctcatgggg caggcggaga ggagcttgca gcattgagcg gaaccggact tgagcccgtg 21180 atg tcc ggc acc aaa ttg gag gac tcc ccc cct tgt cgc aac tgg tca 21228 Met Ser Gly Thr Lys Leu Glu Asp Ser Pro Pro Cys Arg Asn Trp Ser 1 5 10 15 tct gct tcg gag ctg aat gaa act caa gag ccc ttt tta aac ccc acc 21276 Ser Ala Ser Glu Leu Asn Glu Thr Gln Glu Pro Phe Leu Asn Pro Thr 20 25 30 gac tat gac gac gag gaa ttc ctg cgg tac ctg tgg agg gaa tac ctg 21324 Asp Tyr Asp Asp Glu Glu Phe Leu Arg Tyr Leu Trp Arg Glu Tyr Leu 35 40 45 cac ccg aaa gaa tat gag tgg gtc ctg atc gcc ggg tac atc atc gtg 21372 His Pro Lys Glu Tyr Glu Trp Val Leu Ile Ala Gly Tyr Ile Ile Val 50 55 60 ttc gtc gtg gct ctc att ggg aac gtc ctg g gtgagtctcc tcccgggcag 21423 Phe Val Val Ala Leu Ile Gly Asn Val Leu 65 70 ccctcctagg ggctatcacc ccctctccgc cccgggctga gaaggctcta aagagacccc 21483 tccctccccc gggaagcaaa caaagaggtc gctgctctcg gatggggttt tctaataaaa 21543 taataataat aatagaaagt tttctgattt tccgaaccgg gaccgagccc tggaaaggtt 21603 attccctgtt ttgcaggaat aacggggaaa ccgcgtttct ttttcgagca cctagattac 21663 aagcgcaggg agaggggccg cggcagggat ctccaggtgg attttgttga gtgtgtgtgt 21723 gtgtgggtgg gtaggtgggg gagtcagtca tccctttgtg taacgtggct gggtgtttca 21783 ggggggttgg gacgagacag agcttgcaga atacaaagct acatccctaa ggagcaagct 21843 ctctgtggct gtggaagtca caaagcattt gtgagctagg tggcattgcc ctttggcgag 21903 gaggtttagt ctccagtcaa gaggtggtaa tgaaccagca gggagtggag acggaggcaa 21963 agcagggaag tgcactcact catagaagct gaattaaaca ggatccatgc ctggagcaag 22023 aaggaggggc atcggagaaa agtaccacag agatctcaat catccatcca tccattcatt 22083 cttacatcca ttcagccaaa tatttttttt tttcagtctg cttgttgcca ggctcaggaa 22143 ttattcatgt caactgtttg ttgttgtttt gttttgtttt gttttctcca aagatgagac 22203 taagcttaat gctaggctat ttgtcccggt ctaggtctgt atgcaaacac gggtttcctc 22263 gacccctcat ccccctcccc ctaaacaatt tctgagggtt ggggaggggg tgagatggca 22323 acatggtgag tgcgatgatg gaatgtatta gggcagttgg ggaatatacc tccagaaaag 22383 gggctttgga agggagggat aacttgaaat aaattgtgaa tggaaggaga gtgtaccttg 22443 atgaatgaag agtagaaggc tgggagactt ttcacatgca gagggcagtg tggaggaagt 22503 ctctgctgaa aatgacagga gatggaggag gctaggagtt gctcttgatt ttcatttata 22563 aaagaagaag aaggtgagtg aggtgagata ggctgggagg ctttgcagtc aaaagcaaag 22623 aacttgtagc tgcaatgggg actgacaagg aaattatcag gctttcagac taacctgatt 22683 tttgccttct ctcccaagtg tgttggtctg ggtagaaatc atcccgagta gtctctcacc 22743 aactcagcag gcagaataga tgatagtatg tgaatgacag gagttctcca gagtgttggt 22803 agaatgttat ttgaggagac aagaaacctc tgagaacttt agtacatttt taaatattat 22863 ttttagactg ttttcctttg gttgatttaa aagtaaaaat aaaggaaatc tttttgggat 22923 actaacaaaa tgaaacaaaa gtggaaatac acaagattag gattcttgtt ataagcataa 22983 ttctgttgat aataatccta atcttgcttt ccttcttctt gttacccatc cttaggatta 23043 catctcttaa gacacatggc taccagcata gcaacatttt actgcattat gccaacactt 23103 attgataagt gaataatcaa aattgaacat atattgagta cctactgtgt gccagagccc 23163 ttcatgtaca ttctctccct taaatatcaa aataacccac attagccaga agaagaaaca 23223 agacttagag aaataaaatg acgtattaag ggacataatt taaattcagt tccatttttt 23283 ctgacctcag atccagaatt ctccattgtt attccactct agagctaaaa agcatataga 23343 gaatagattc tctgctcctg attgtctgca agtttattag atgtgttcct gttctcctct 23403 gcatcaacgc ccactgccaa taaagtacaa tgagggatta atggcactgt cattctcttc 23463 accaaaaacc tttccagaga agcagtaatt tttttatgaa tagctatcaa tagtaactat 23523 ttgccttcct tattttaatt ttcggctgaa tctttgtggt aaaatgtgct cttctttgtt 23583 gttattgcat ttttaccttg catagacctt gtagtgaata gtctccatat cctaattgca 23643 tagtttaggg atacatgttt gctagcctgg ggagttttag tttcaagaag gaaacacctc 23703 tacagtaagg ctacttgttt cataatgtca aggaagatag cactgtccac agccccaagt 23763 gctgaaatgg ccaattccat tcagcctaaa aagaaagatt tactcaaagc actctgcctt 23823 aaagaaactg acagctattt tcctcaggac tgaataacac tgaaatcctc tctggttgaa 23883 ctgaaatgca ttcttttctg acatactgcc tgaaagttga tgaggtttag gtttgacatt 23943 taaacaaacg agtagtgtcg ttactcacag acaacttcct gctctttgat gtcactgtca 24003 aatttgcaaa atgaattaga ttgagaattg cttctttgcc cctctggtat aagtaatttt 24063 gcacatagag tggtaggaca ggatgtcaca tgatttatgc aaaataaaga tgcaatatta 24123 agtatgaagg taaaatacca cagtgtaggc agcagatgta atcactgagc cttcaggtcc 24183 agtcaccatt tgtactttca tataactgct tggaaaatct caaccttttt gggcttacaa 24243 atataatgcc atcagttaga agtcatcttc tccacaatgt cctttcatga agtgatgtaa 24303 taggatatgc tgtgggtagc ataacaaagt cttgattgtc ctcatctctt tttcttctcc 24363 ccatagtccc tctttatcac tatgccacct ctccactctc atatactcct cccaaagatg 24423 gaaagcagtt tcctggggga gtaaagtttt aaatagaatg ttatgagtat ttacattcaa 24483 tgaaaagctg taagcatgtt taatgtgaaa ttttaagttc taaggaagga gcatagggta 24543 aggttctttt tggaaggagt atcttttcag tatcttcaga ataatgccac ctataaccta 24603 ttcctaacta tgtcttctac tacagctaag tagatgtatc aacttattca attggtatat 24663 tgtgagcatt atcatttttt taaattagtg tgtatatcag gggagcctct ggggaaatgt 24723 aaagaaatgt gactgatgtt aatttttact cctgattcct tgaatgacaa ttgtagggag 24783 aaatgtgttc tagtcagttt aaacattaag tacctaggga aaatgatcaa ttttctgctt 24843 ctcatatctg cattcaaaga tatcatatgt ttcatctggt atgcttctgt catatctgtt 24903 gttgtctcca tatggaaaat aggaaaacat cagtctagct atgcttcttg cttcttgtgt 24963 gccattagca agttattgaa ctatccaagt caattttttt ataattacaa attaaagatc 25023 gataatgact gcattataga aatagtatca ggatataatg tacgtatacc ctctataaag 25083 acatataaag ggacacaggc atatacatat ttttcttgac acatagacac taattaatgt 25143 caatttttat cccttaattt tcatgactga actttttgtg atgtggtgta tagccagctt 25203 ctgccttcat gggccagtct gtatctctgt agctctttat ggcctctgcc ccagcctttt 25263 ccttaattgc atattttcct aaaaggtgtg aataaaatgg tgttggcaca cattactctc 25323 cttttccaca ctagctccac ccacccatct ccttcatact gattgcttaa cattgccttc 25383 ttgcctttaa atgaaagcca ttcctaacta ttggaatagt ttgctttctc tctcaactta 25443 aatttgcctg tgctgggtcc cattcattta gagtttttga gttgttaata ggttgttgat 25503 aggcaggtct atcactacta gtgttttaaa taacacacac attggtaata tgttgattta 25563 actcatacat tgttaaaata cattgtgaag tattcatagt taaaataaat tatccattaa 25623 gtaatttacc taataacagt ttacccaagt taggtgtgtg gaatggggaa atatttgtaa 25683 taagtttgct tcctacagag ttagtcttgt gtcagatatg taagtggtag aattgcaagt 25743 tcatgttact cctaagccta gagacattta ttttctgctt ctccgaatgc ccattttagt 25803 ttcatgggtg tttgtaaacc catccttacc tacacaggaa gcaaaaaggg gttatttcta 25863 aacccttttt agatatagaa ataatacatc actcatctcg gccaagactc aatagaatca 25923 tgaatagtga ctgtaaaagg taatattaac tattaggctt taaacctatt gtgcatttta 25983 gttttaaaat gcaaacatgc taatctgaat aagaattaat ctgatgcctc tacatttttg 26043 ctaaaatcat aactgtttag tcttacttag taaaataaat tatatctttg acttaaaatc 26103 ccaatgataa cttttaagat ggctatttca tagataacag caacatttat catggacaga 26163 caataatgag aataacatgt gcaactgata atttaaatgc aatgagttat ttctgtattt 26223 gaaaaaatat atttgggaaa tgggataatt aaaaaatacc agttttcaag agaccaaatc 26283 taaaactcaa acataaacac aatgctccag tttttagaaa actgtcttga ttgtagtagt 26343 gcctacatac taaattgtat catatgattt atattaattt tccttatttt gtattttaga 26403 ttatatttga aaattttcat gtactgcagc tatgttagca tctcaaagtc tccatattct 26463 cactccgctc cgaaacatcc actgctgatg ttatttaact agtgaaagaa gatccttcca 26523 tgtttcttct tatagcattc tgacatcttc tccaccctaa ggaatgctgg ctttattaag 26583 tatgtttcag tcaatgacat gtgattggtg aagctgacgg tatttgtctt cagttccttt 26643 tttccctgca aaggaaattt gttgaatatt tattgggtac tatatgccag gtactatatg 26703 tcaggctcca cttacatata ctctattgat gccttacaac aaacttataa tgagaagatt 26763 aataggtttt acaaataaga aaaatgaatt caaagagcaa tgctaactta ctcaaaagtt 26823 tagtcaggca gtaaatagca gcactaggtt tcaaatatgg atttaacaaa ttccatggtc 26883 catgcttatt ccattacttc atcctgcctc tttccttagc ttctaaccct gactggagat 26943 gcataggcaa aaagaggaag gaagagatac ttagatgtgc cctctagaca atttacagag 27003 ttgtttgggc atgttgccat gctgtttttc tgatagacta cagttcttca gctctgagga 27063 tgagctcatt tgataagcca atcaaggtcg ggctagggtt actttacaag agaaaatttc 27123 aaggtaaaat aggtgctgcc aaaaatgctt ttacctgttc agggggttga ctcactggaa 27183 aaaaaatgtt agataattgt ggccaaggat tattttgtta ttgaaagtgc tatttttaga 27243 cacaatttga gcctgagagc ctaaacactt aacacttcac ataatctaca gatatttgtt 27303 tatttttctt tttgtcatgc attgccaaat aaatagtatt tatttaaaca aatcatgttg 27363 ctattgattt tattaaatag atgaactttt tttaattttt tttttttgag atggagtctt 27423 gctctgtcac ccagactggg gtgcagtggc acaatctcgt ctcactgctg cctccacctc 27483 ctggcttcaa gctattttcc tgcctcagcc tccccagtag ctgggattac aggcacatgc 27543 caccatgccc agctattttt tttttttttt gtatttttag tagagatggg tttcaccatc 27603 ttggctaggc tggtcttgaa ctcttgccct tgttatctac ccacctcagc ctcccaaaat 27663 gctgggattg caggcatgag ccactgtgcc tgacgtgaac aggtcaattt ctatatcacc 27723 ggacagtgtt cctggatcag aataatatat tatatgtatg aagaatcatt acctattaca 27783 tcagacatga aatgaccttt agatactgac tttgaaagag tttgagatgc tattggatga 27843 aacacatgac ccatatgacc agtcttttga attgctgact ctgagtataa aatgttttca 27903 tttcaccttt gttcacaatg agaagtgatc tcttaaccaa gtaaatgaat taaatcgata 27963 tttaaaataa cattaaattt cttgccagaa aaactgttct ttcataaaca aaaaacaaat 28023 tgctcaaaat aaatgactat atctttattt ctaaaaaatg tttagagatt attattattg 28083 ggtctttaca agtaatttgc cttcaatact aaacacatga gaacaatgtt taatatttat 28143 atagtatttt actcttcaga agatatttgt ccatattctc tctcagttat tcttcacaac 28203 aacattatga ggtaggtctt ttttaatgaa aaaaaactca agtgcttgaa gtgatttaaa 28263 atcactgtgg aagaaaagca tgggcataca gaaaagccaa gtggttgtgt gtcagcttgg 28323 gaaaagcttg caaatttcct gtatttcaag aggccaggat gaggtgtgta attatctttt 28383 actggtcttc agctatcctg tctttgatat gtgattgtgt caaaactatg aggaaaaact 28443 cacattaaca aacttcataa acttgttaaa cataaaataa taatttcgat gttttaattt 28503 acagtaagag tttattctta caagtcctta aatacccaaa gttctttcag ttatcatagt 28563 ctttttcagt agacagaaat ccatgtggac tgttattgtt ctgaatagct aggctatgcc 28623 atagtagcaa acaaaccctg aattttcatt ggcttagtat cacgaaagtt tatttcttgc 28683 tcatttaaca tctgaggtgg gttggagagt ctccttcatc caatgactca cagttcaggc 28743 agcctccaca ttttgtgcac tatccctaaa aggtggactc tgtggtaatc agtttccaat 28803 atggcttcca atgaccgccc ccgggccccg gccccacttc ctgatagtca catcatcgtg 28863 tagtcccttt gcatattatg ccagaattgg tctgggtgac caacagctca tagcagcagt 28923 gaaacgatgt cactttcaag attacataac aggagcttac agcttctggc tcaagtaccc 28983 actttctctc tagctcttgg atctcttctt ctggaggaag taagctgcct tgtggtgagc 29043 agctgttggc tggagttaaa atctccagcc agcagccaga gaggaaatac ggtctgttaa 29103 caacctcatg tgtgagcttg gaagcaaatc cttcagacca ggttgagtct tgaggtgact 29163 acaacagcca ctaccccaac ccacccccag cttcagtgca acttagtaac agacactgag 29223 tcagaactat tcagctaagc ttcttgcaga ttcctgacca ttcagaagct atgtcataat 29283 aaatttttgt tgtttgactt cagtttcggg ataagttgtt gcacagcctc taaagttgtg 29343 aactagaaga agtatactgg ctcttaacca cctttgccaa aaattaacac ttgtcagtca 29403 tggtcatatt catttggtcc aaatcaatca tatcgtatca acctaactac aaaggggatt 29463 gggagatggt gatgtctctg tcacagaatc tatataatag ttaaaagtat ttttaacttg 29523 catagactca gaacaagata atttggagga attcaatgct taatggcata ccactaagat 29583 aagctgatag atatatcgtt gcgatttggg tctctgacaa tagaggcaat tgataatatt 29643 aagagactat gtgccaatta ttgtgcttgg attgagggta caaaggtaat agaatccaag 29703 gaacctgcac tctttttgaa agatagacac ataaacacat acttttaaaa taacgtggta 29763 agtgctacta tgacagatgg ttgcacagaa tgtagtggaa gtatttgaga aggacactta 29823 gctctgctgg gggattagag agagatacag gaggagatga cacctaaact gagttttaat 29883 agatgaattc aagttaccca ggtgaagaaa attgggtaag gatgttctaa gcagaggaaa 29943 caacataagc aaaatcaaag aggcgtgaaa tagaatgagc tatgaagaaa gtgttaggca 30003 attgggtaag tccaatgtaa gtgcagatga ggagagtctg gaaatgaggc tgaagcagta 30063 aataaggatt ggccataaaa gaccttgtgt acaattctta agatctaggc tttgacactg 30123 ttgtttaggg ggagctgtta aaggatttta aattagagta ccatcattgg tttgcatttt 30183 ccatgagagc attttgagga aaatgcagag aataaataca tgaggggaaa gactagtgaa 30243 ggttttcaca ctggggtttg catcctgttt tggcaataag cttgttttaa tgaaaacaaa 30303 caaacaaact gacaataaag aacataatcc aaattctcca gataattact tccaggaggc 30363 tttctacgtg ctgcatacaa aacaaagaaa gaaaaacata aagtgagaaa acgaaggaaa 30423 aacaaggaaa gaagagaaag aaagaataca tattggaaaa actgttgctg tttttgtttt 30483 gctgaatatt taaatttgag aagcaatttc tctttttctt tttacttttt tttttgagat 30543 aaagtctcac tctgttgccc aggctggagt gcagtggcgc catttcagct cactgcaacc 30603 tccgccttcc aggtcccagt gattctcctg cctcagcctc cccagtagct gggacttcag 30663 acatgcacca tcacgagcag ctaatttttt gaattcttag tagagatggg atttcaccgt 30723 gttgctcaga ctgatcttta actcctgagc acaggcaatc cgcccacctt ggcctcccaa 30783 agtgctagga ttacaggcga gagccactgc acccaggcgc aggttttctt tatgatgttt 30843 taattatatc tttcttggaa catatatgta tgaatcttgc atgccatagg tctattaata 30903 ttttccaata ttctacatgg ttttttacta aaatcatttt tatgattagt tactgactga 30963 ggtttcaatg catcactgta ctcctagcta tctctcattt tagcttttac atcacatttt 31023 ggcctcacac tgaaacacaa aatattaaaa atttgagatc taataaacaa ttttcacatt 31083 ttccaactaa atccccactt ctttctaaat tttctacaac tttctaaaca ttctcacttg 31143 aaaatttatt ttaaatgaca tgtattttat tcaaacaatc aatgaagatg ctacattgac 31203 cccaagtgag cccttaggga atttccgtga atatttccct acaggttggc atggtaacac 31263 acttcacaat ttctaaatct gtggatagtt tagaagcttt tatttgctgt tcctagttca 31323 caatggaaat acaacaatga ttaaaaatta taatatcctt ttgtagattc ttagctttta 31383 ttcctactca gtgactctaa aatgaattta taaggcccat ggtttataac catgtgaggc 31443 cttgattttg tcactacatt gctagaaatg gggtcagaag gccaccagct ttaataattt 31503 aattcatcaa ttcggaatga atttgatgag tcaaccactt tggtagagaa ccatattgct 31563 cataaatact gttttgaagg caattcgtct ttcataaaat gtgaagattg tgctgatctt 31623 tctgggcagg gttatggagg tgtgattaaa tgcttaagaa accattttgt tattatatta 31683 aaccgaatca actttttatt attaaaaata gataaaaact tagcatcctc aattataata 31743 ctttatacaa aagtttccca attttatata gactgaagat aaaaatacat taacaaatct 31803 taccagctgg ttcaggaaaa taacttcata attattgaga catttatgtg tttgggcttg 31863 atttatactt tggacacagg aaaacctaga gagatctggt tctttgaaat catcagagat 31923 ggtgatggtg actcagagat tcctgaaaat cagtaagatt accctagttt atagacgtat 31983 gtgttatttt ttcccccagg cataatgaac tttataactt gtcattgaca agaagccaaa 32043 tcatcttaga gaaaaggggg agaataaaaa tttaagaact taaaaacaca taaataaaaa 32103 catgtacata cctcacacat gtgtacacac acagtttggg gattggatga tatgaataat 32163 ataattaata caccctaatt tttcatgcag gattaagaaa gtatcttcca aacattaaaa 32223 atgctgaaaa ctggacataa ggccttgagt ttcccaaatt caggacatat tttcaactat 32283 cccctgagta aatgaactat aacatttaca gaagtaaaaa tgataaatac actaaagatg 32343 aataagtcct tgaattaaca gccaaacaag aaggcgcatc ctttggatga ttgatcactg 32403 tagcatgatt tcttttcctt gaatagacaa tattccttga caatctttct gtaaacagaa 32463 tacaatgttt ccctaagcaa tatatgcgtg ctctagagtt ttcacaattt ctgatcctcc 32523 tatgactggc tcctgctcag ctcacactgc actttcatgg aagttctctt agaatgccag 32583 ctttgaatca ctgctccctc atgtgctgtg tgtgatagca tcccatttta gttttgtcat 32643 agaattgatt accatttcaa attgaattgt taatttattg ttcatttttc tgttgtctcc 32703 cttaagtaaa aggtaagctg catgagaata gtttcatttt ttttcctgtt tgccaatgta 32763 tcctcagtgc cgagaacagg ttcaggaata cagaattttt agttagcaaa tgaattaaag 32823 tgtaagactt ccagcaggag gaatttttta catataagta cattttttaa attaagcatt 32883 gcaggcttta aatttcttct atataaatat ttaaaataaa gcttcaataa tttgaattgc 32943 ttttgtgatt attttgtttt ataccttgag taacttatac atcaactatt ttgtagttat 33003 tctagtaatg attatgaaag accatttgaa aatctttccc cagcactgag atctccttga 33063 catgactaag tgatttatac tatgcaatta tattgctctt ctcaagaaaa gcaaaatgaa 33123 atttacaaat ttggtagctt tttgttcttt tgttttctca agtaagatac accaagattt 33183 ctttaaatga tacgctatat ttctgcaata actgagaaga acatgtaatg tgcaaaactc 33243 ttaaactctt tttgtttcaa aataattctt ggttgttttt ataaaagtct aagcaaatac 33303 ttaatgaact gtgtcccaaa tgaggtgaaa cagctgtgac agaatgttac tatgactctg 33363 tactttctat aataaaaagg gacagacata tcctcacctg agccttggga tgtttcaggc 33423 atgcccatag agcctaagct ttaggaatcc tctgtcattc ttttccattg ccagtgactt 33483 gtgccaattc tagggttctg gactgtgcaa acaatggaaa aaataataac actttcaggt 33543 ggcgcacaaa accaatgttc atagtagatg gatagttcta gacactttat ttaatagaga 33603 ataggagaaa cactaatccc atctaattct gccttcaaac tcctaaaata ttcatcatta 33663 tgaattaaaa aaaaaaatca aagtgtaacc tcacccagag aaagaagaca ttggggccag 33723 gtctggtggc tcatgcctgt aatcccagca ctttgggatg ctgaggcggg tggatcatga 33783 gttcaagaga tcgagaccat cctggccaac atggtaaaac cccatctcta ctaaaaaaca 33843 aacaacaaaa aaattagctg ggcttggtgg catgcgcctg tagtcccagc tacttgggaa 33903 gctgaggcag gagaatcact tcaacccggg agacggaggt tgcagtgagc caagatgaag 33963 ccactgcact ctggcctggt gacagagtga gactccgtct caaaaaaaaa aaaaaaaaaa 34023 aaaaaaaaaa aaaaaaaagg aaaacgaaaa gaaaagaaag cagatattgg taattctagc 34083 agatcctgga acaactgaac caaatttatt aatatgtatt attactgaaa atcagtaatg 34143 aacaaaattt acagaatggg cttcttggag ttgttacatt tcccttatta cataactctt 34203 caataaaagt gtttgtcata cctattttag ttaattctac aacaactagt gtgatagggc 34263 tattatttga tctttttttt tttttttttt ttttacaggt agtgacattc agtattagac 34323 agctgctatt gtgttagttg tctgaatacc tttacatatt atcaactggc cttttcattc 34383 ctgagttgtg agtaaatgct ctgtctccca gactggagtg cagtggcgca atctcgcctc 34443 agtgcaagct ccgcctcccg ggttcacacc attctccagc ctcagcctcc cgagtagctg 34503 ggactacagg cgcacgccac catgcccggc taattttttt ttcttgtatt tttagtagag 34563 acaggttttc accatgttag ccaggatggt cttgatctcc tgacctcgtg atccacccgc 34623 ctcagcctcc caaagtgctg ggattacagg catgagccac cacacccggc cataaatgca 34683 gtcttgtgtt ccccacttcc attcctcctt tgacagtaca gctatgctag tctgcgtagc 34743 aaattgaaaa aatatgacct gtgggattta aacaaaacac agtgtcatac acattttctg 34803 gtaaacttaa ccaaaaggga cttgggttcc ataactaatc accaatgcct cagtgatctg 34863 taactccttg taggtacctg atcacagtta ctaaagggaa agaggagcga ggaatacaag 34923 agcaaagtca agccagacat agattttatc tctttgtaaa caggagttca gaagaccgct 34983 ctgaatgctg agttagcatc agcaataata gaaatatatg cagattgttg atttgaagtc 35043 atgcaaagat atctttttca tccaaatgga ggcaaaagca tcatagagca ccagagggct 35103 aaatccaact gtagcagcaa aaggtacaca gaaaaataaa gcatcctgaa ccaacgcact 35163 gactttctag ggcttatcta atttggagct atttcctttt cttatttcat tcagcaaata 35223 tttattgaac acccacaatg tgtaatctgt tctattacat tctgtggagg aaatacagaa 35283 gtgaatgagg catggttctt acctacaagg aatttctaat cttgtggggg agactaacat 35343 gtaaacaata aactatagta tgaggattac tgaagaggca tatgctaagt ctcagaacat 35403 tgaaatataa gagttgggtt tgacatgggg aaagaaatac cttcttcact gaggaggtag 35463 cattttgagt tattgttgac atgtgaatac gattttgaaa agttccaaag aatgaaaaat 35523 tccacctaca ttggtgaagt actaagatta aatgcatgat agcttgaaga cacaaaaata 35583 attatttata aaccattcca aaaatcattc agggaattcc aataatacac aagtttttaa 35643 acacatttct gggtaatttt gagtaataag gtcttaatct cctctactgc tttcaattgt 35703 ttttgtggcc ttctttattt tgtgggtatc tggcccagtc ttgtctgtag tgtattatgg 35763 tggattggat taaacatgtt ttgcaatctc tggagtgatt ttaaaatgac ttgtgttata 35823 tcagagtttc ctaaagggag attaatttgg cttaatggta agaacggatt aaagttatga 35883 gataccagac actgggaaaa cagttagaag cctgttgaga ctcttcaggg cagttgttgt 35943 gagaatgaag ttaagacaat gggatagaat atgaaaaaaa atgaaacaaa catgagaggc 36003 agtctgaaga tggaagttgg caactcatca aatgtgagaa atttatagga acagaaaaga 36063 acctgctgat taatataaat tttctgccaa agaaagtaca gtggctctcc tcagcaaact 36123 aacatgggaa cataaaacta aacactgcat gttctcactt ataagcagag ctgaacaatg 36183 ggaacacatg gacacaggga gtgggacatc acacactggg gcctgttgtc gggactatgg 36243 gagggagacc atcaggataa atagctaaag catgtgggac ttaataccta ggtgatgggt 36303 tgataggtgt agcaaactat gatgacacac gtttacctat gtaacaaacc tgcacgtcct 36363 gcacatgtat cccagaactt aaaataaaat taaattatta aaaaaagaaa aagacagtgc 36423 ttgtcttatt cgtttttttc ttaaaatggg aaatatgtaa tatatatcaa ctgtagtgta 36483 tagaagggtc atgatgaatt ggacaaagat acgtggagtt tgaattgcta gaggagtacc 36543 cacgtgcagt tgtccagcag aaatcagggc ttgttcccca acatgctatt cacaatcagt 36603 ctactactct caggtatttg tttttctgtg tggctatgca agcaatagat acagtttatg 36663 tgaaaatgtt ttagaaaatg tcttctggaa taattaaaag catacaaggg aatgtaaatc 36723 tcttaatgtg acaagacctt tttgccacaa taaacaaatt cattagttca aaaaatattt 36783 attgtgtgcc tattgcagca aacaaaacag acgaagctcc ttcttgtagg gaacttatac 36843 tctagtgata tttagtatat attttgacaa ttgaaccaac aggatttgct gacggattgc 36903 cttatgggta taagagaaag agaggagtcc acactttcat gccaggtagg ttgatggagg 36963 tgccatttac tgagatacag ggccgtagag gaggagtgtg tttgcagcag ggaaggagaa 37023 gactcaaaat ttggttttga tcatactaaa tttgatatag tacaggtaag tgtatggtgg 37083 ccattagaac atgaaggtaa gagtttagat aaggagacag gtatggtgaa atacatccaa 37143 tatttataac caatattatc ttttgtgtct gtaccttttt atacattccc catatatatc 37203 aaagactata gaagggactg gatagtgaat aagtgattat acataaattc ttttttacag 37263 attattttgc tcttgatttc tcctatgtaa atcatcacag ctacattttt taaaatctta 37323 aaaaggatta ctttgaacaa tgcatttaaa catccagaaa acaaaaacag gagtgcatgg 37383 taaaaattct gatttcagaa cgtatgcctg acttatcaag tcagaatttc agggagtgaa 37443 gaccctggaa tctacacttt aaatagagcc tcagttcacc aagtatgaga agtcctgtaa 37503 cagggaaaag taacctcctg ttatatttga tggaggccaa ttgacaagcc aagtagtttt 37563 ccatttgaca aaaattctat tgtaccaatg aagagctatc agaggggagt agattaaaac 37623 acctcccttg aaatggaatt tggcaagaaa gcaagaaatt acagcaaaaa gaccaataag 37683 aggaattagg ggcaatgaag gaaggagcaa agatgtggga acccaaaaag ttttcctagt 37743 aacaactttg aaattatatt tttagtatat taaatttaaa gtagagttat tagtgcatac 37803 attggtgtaa tttattatta tattaagcca acaatatact tttaaactta tacaactttg 37863 caaaaaagta caaatcagaa gtctgggcta agtagaatgc ataatagaat cagtagtgca 37923 aaatattgtt ctatattttc tagcttatga ttttctatat aaagtcagtc tttcaggatt 37983 aaaatgaatg tcacttcttt ttaccatgtg tcctttaaat tattaaaatc tatacacata 38043 ttgctataca tagtaaatat agttagtcaa ttatgtcatg gaaagaattg aagggttgtt 38103 ataaatttaa aggtgtttca ctatacaaaa acattgtgaa atactggtgc tgatttagtt 38163 ctagtatctc tgatatatta aatcataaat gtcaggagtt attggtcaca aaataaacac 38223 cagaattata tgacagtcta aaaacaaaaa caaaaaactt cagcaacaat attgaagata 38283 tggaagtgcc agaagaataa ggattaagac aatgaataaa aatctcttcc aaggactggt 38343 ctacactaag agtttagaaa tgcatttttt tttcacagaa atatccttaa tcctctatat 38403 agaaatgaga agaaaacata agactttagc aagctccatc taatccattt gcagacatat 38463 ggttacctat cttttcttca atatattgga gtttgcaaat attctacctt caaagaatag 38523 gtgttaccaa aacattgtct gcaagatttc taagatttga aatatatttg ctatagtagg 38583 ttagagatga gacattttta ctttaaattg caataattca gacttaaaat ataaaatgtg 38643 taagtctaaa ttttttttct attcattgca aatatatctt atatatacat aaaatcctgt 38703 gtatactcat atgaacttta aggaaatatc agaggcatca gtaatagata acttgcatct 38763 cttttacatt cagttcaagc tactcaaatt ttaatctttt gttttcattc caacaaaaaa 38823 aattaggatc tgccttggct tttgctaaga aagtaattat tggctggaca tggtggctca 38883 catctgtaat cccagtactt tgggaagctg aggtggacag attgcttgag ctcaggagtt 38943 caagactatc ctgggtaaca tggtgagaac ctttctctaa acacacacac acgcgcacgc 39003 gcgcacacac acacacacac acacacacac acaaattagc tgggaatgat tacacgcctg 39063 tggtcccaga tacttgggag gctgaggtgg gaaaatcacc tgagcccagg aagtcgaggc 39123 tacagtgagc cgtgattcca ccactgcact gcagcctggg tgacaaaaag aaagtcatta 39183 tcttcaacac tgtgcataca cacttttctg catctagatc ccaaattttt gttttgtatt 39243 tacatagaac attgataagt aaggtaagta ttaattgata aaacatttca aactcatttt 39303 tcactaaatc caatggcctt cctcttttgc atgaagtctc taagaatcat gttaatctac 39363 atactcaatc tacgtaacaa ctggatatat cctgtagttg ttgcccattt ttctgctaaa 39423 tgttatcttt agcactaagc atgagtatga ggaaacagta tctgtgctca gattccagaa 39483 atgaagaaaa tgtactggag gtcttttgga taatggctac aaggtcacag ggactgactc 39543 ctttggaagc tcagcgataa ccattttcag agagaatatg tcaacatctt tcagtctaga 39603 acttgatgtt ctgctgagat ctaatctggg ggtgtcctac tattgaatag gtataaacta 39663 aataaaaata gtgagagaac attcatgtgt tcactcattc attccttcat caaacaaata 39723 ttgaaagtct attaattggc aagcactctt ctgacattag aaggagcaaa gataaaaaag 39783 atattatcat taacctcaag gacatgacag catcatggga aggccagaaa tgcaatatgt 39843 taaagtaaaa cacagtgtag tgtttactac taaagagata taaacagagt actgtggtct 39903 aaaatcatat atataacatt tgcttaatgg atgagaagga aactttaact tcaggaggca 39963 gagcattaag aaagtgaatg acaggagggt caaaagaaaa agccgacagt gttgcagagg 40023 cagggcataa aggagctaaa cctttgctac cttcagtttt tattatccac agaacgacaa 40083 agaaacaaca acaacaacaa aactttggat ttgagggttt tttgtttttc tttttttttt 40143 ttttcctctc attccaagca tcaaaccttg ggatttattt accttctagc aaaccaaaat 40203 ttatgggggc attcctatgg tcctcacctc accccatttt tctgttttac ctatgaaact 40263 tgatcaaaat actgtctcca catttctcat aaaatacatt agtttaattt tctactatta 40323 ctttctttta gttgatttaa aaaaaggtca tttatgacct atttaggtta gcatcattaa 40383 ttttatcaat gtaagaatat ggtagtacag tgtgaattcc attaatggat atgttgatac 40443 catgggtttc tctgaccttt cctcttccgc tcctccctga tgattggttc tgagcttatt 40503 atcatgtcag caatgaaaca gaaaagggag aaaaatctca agtaggttgt ctgtctcttt 40563 aacactgaat aaagattttt ttttctctaa cagacttaaa aatagtgccc taaaaatgtt 40623 ttgtttcatt tgtctgaatt cccattcttt cccgtgatca tagatagttg agctaaaaaa 40683 agaaaaaaca aaaaacaaaa ataaacattg tgtcctacat ttgtattaac tttcttagga 40743 atgagaagta gaatcttaaa aaccttagaa tgggagtttc caagctagct tgcaggcttg 40803 agttttattg ataatacctt taggatgcat gtattattag aaacatcagt tatttacaag 40863 ttcacctatt taaaagtcta ataggaaaaa atatttcatg ttgctaagta tgtgacttcc 40923 ctttaaaaga taataatgct ttccctttaa acaacaatag taaaagaagt agagttcctt 40983 ttaaacacat acttttatat tataacccat tctgtttaaa aaatagcagg catataatct 41043 agaaatgcaa ataatttagt gaaattttta aaattattct acatataatt aaatatggat 41103 attcgttttc aaatatcaaa taataaaata tgtctgagat gctgactaat ccttaattat 41163 aggtgtgatt tctacttcac catcaatact atggtactcc aaatcttaac atgagtctga 41223 ttttctaata aacatgatga aaaaagttat ggaaaaattt tgagatttac tttgggaggt 41283 tctattgtgt tctgttcagc ttcataatat tcagtttcta tgagtttggt atttaattat 41343 gtgtgtttgt cattcagtag gctggaagta tgaccattgg gagatcaaaa cgataagaca 41403 ttaatgacag tgctttatca ctgaatctag tacttttttt aatgaaagag atgttggcct 41463 cttgtattgt tataaaacaa cacaatttta tggctttaaa ttaaagtaca atcataacag 41523 aagacaaaat tagattaaaa aacaaacatg gagtgactca tataaaatat ttagaaacca 41583 ataatacaga tagagacaca ttagttcctc tagacattgt gttttccagt aaaatgatca 41643 ccaaacttac caggaaaatg ataattatca gattatttac tttcagaatt aaaggcagga 41703 agagaaaaaa atgaatgaag aggaaacaca gtaaccatat aggacaataa gagtgaatga 41763 agataaaatg aaaaatcaat aagatatcga ctttcttaaa agacaaatat cacaatagga 41823 aacacctcag aaagggaaat ctcaagaaaa taataaactg aaagaagaaa acatatcaaa 41883 acaacttgag gactgacaaa gttttaaaat gtatttagat aaagatacca tgaggaaagt 41943 gatcaaggtg ttctaggtaa tcactgaaga taaaactaaa aatagcttaa attaaaatca 42003 gatagagaga aggtaactga aacaggcata gaaagaaagt aagaaggaat acaatcctga 42063 acatcttaac aatgtctcaa atgtcaggaa ttgatccagt ttttggctgc acaacagagt 42123 ggctatagtt aacaataatt cactgtatat ttcaaaataa ctcaaagagt agaatcggaa 42183 tgttgctaac acaaagaaat gataaattct tgaggaaatg gatatcccaa ttaccctgat 42243 ttgatcttta cacattgtat gcttatataa aaacagtatt catggccggg cgtggtggct 42303 cacacctgta atccctgcac tttgggaggt cgaggtgggc ggatcacaag atcaggagat 42363 tgagaccatc ctgtgaatgg tgaaaccccg tctctactaa aaatacaaaa aattagccgg 42423 gtgtggtggt gggcgcctgt agtcccagct actggggagg ctgaggtggg agaatggcat 42483 gaacccagga ggcagagctt gcttgcagtg agctgtgatt gcaccactgc actccagcct 42543 gggcgacaga gcgagacttc gtctcaataa aacaacaaca acaacaacaa caaaaacaaa 42603 aacagtattc ataataatta aaataaatta tttttaaaat aaaataaaat atcagtaatt 42663 taaatttttc ctatagcata gagatctgta attaatactt gtcgatcatt gttgtttctg 42723 tcttcccaac aactacactc ctgtttcttc acattccccc ttcttctaac agcactacat 42783 ctttctttag gaaactatcc ttttgccatt tcatgtatat ggtggggtgg gggagttatc 42843 aatcacagta ccccagcaga tgggaccaga ggcaaaaatg cctgaccttc tcccatcccc 42903 caaccacagc agcaaatgaa ttataatttg atgcacaagg aagtatcgga gcttttgtgt 42963 tgggttttac atatcacctg tgggagataa atgaactttt ccccacctaa cctttagcca 43023 cttgggatga ttagacatag aggtgcctaa gatctttccc tttgccacat taaaaacaaa 43083 tcatctatgg cacgagcata caagaccagc tttcagagac acaaaatgat ggagagaacc 43143 atgatactag ttttagacct agtcactgag actttctctg ctccttccca gttacctgag 43203 ctttattttg tttacattta tcagatttga atggctgtac ttcaaagtac tgattaaaat 43263 aggaaccaac ctatatgatt caggtggtga gaaggaagaa aaagagagaa aatgaggtta 43323 acaaaagaga ataaagaaaa agaaagaagg aaaacaagaa actctgacta cctctcctct 43383 ttgacatagt ttacacttct gacagattgt tcttctctaa atttatgtag agattagagt 43443 gaggatgatg tatgcactgt agcatgggtg gtcttccagg aagccttgac tgaatgaggc 43503 aaggagtatg ttgctccctc agtaacctca aatttacctg caagcctgat aaaaatctaa 43563 cactaacact aaacccaatc ttatctacag ccctaactgc accctaatat taacaaccct 43623 acctctgtac ttcaaaacta aaactaattc tgattttact cccatctgcc ccttttaccc 43683 taaaaccaac tgtaaaacta aatttaactc taaacgtaat cctaaaacta agaattaact 43743 aacaatttta tctctatacc caactgttaa ccccaagcct aactctaatc ctatctctaa 43803 cctaacatta accacaaacc tacttctaac tctaatccta accataacct caaatctaac 43863 tctgattcca attgtaatct aaacaccaac ccacccctac ccttttatcc caaatccatc 43923 tgaaaccctc atcagaacac aaattccaat tctacttccc accctgactc tgactctaaa 43983 cataggccca aatataactc taactcgaag tcaaaaactt aacaaacctt atcttgaaac 44043 tcaaccttta cactaacccc aattctatct gtaatcctaa ccctaatatt atcatcaaac 44103 ctatgtctaa cacgacctcc aacccaaaac caaaactaac ctcagaccta actctacatc 44163 taattataac ccaaacccca ggctgctact taccataacc ctgaaactaa gcttgatcct 44223 ttctcttttt tttgagatgg agtctcgctc tgtctcccag gttgaagtgc agtggcgtga 44283 tctcggctca ctgcaagctc tgcctctcag gttcatgcca ttctcctgcc tcagcctccc 44343 gagtagctgg gactacaggt gcccgccacc atgcctggct aatttgttgt atttttggca 44403 gagatggggt ttcaccctgt tagcaaggat ggtctcaatc ccctgacctt gtgatctgcc 44463 tgcctcggcc tcccaaagtg ctgggattac aggcatgagc caccacgccc agccgaccct 44523 ttctcttaac ctacactaac actaactgta aacctagctg taactctaat tgtaaaccta 44583 acctgattac tcactacaaa ggtccctcta attctaacaa gaaactcaat cctatctcaa 44643 ttccacccaa ccccaaaagt aaatctaaac ttaaacataa ctcaaaatgt atctcaaacc 44703 ttaaccttca cgaaactaca tgtagcacta atgtaaccct aagcccaatc ctatcagtaa 44763 cactaatgct aaaacaaacc ccaatctgta tctctacccc atcactgaca ctacccaaat 44823 cccaatattt aatgctaatc attaagtctc aaactaactc caaacttatc tttaactata 44883 tctccaaccc taaccctaac attaacccca aacttatcat taatcataca tctagctcta 44943 aacctaaccc caactttaac tcttacccta gctctaaaat taaccccaac actatctcaa 45003 actgtaatcc taatgctaac gttcaggcta cttttaaccc tcaccctaca caaaatcctg 45063 cacctaaact caaccctaac tttaaaccta cctctaatcc aaacactaaa tttaaatctg 45123 gatcacgact tgggcatact agcacccact agtgttctgg gtgtcatttc tttgcttcac 45183 tctcatccag ctttctttac taattttgga taatgaatca gaaaatagtg gtgtggaatc 45243 agggtctttg aattattgta ttatccagag tttgtcctgc tgcaaatgat aaaacactga 45303 aaattagctt aacaaggaaa aaaataaaaa tgtgtgtgca ggggagaagt aggagagtta 45363 ttggctcaag gaacagaaga attcagtact gagtttcaca aatacctgga ttccctagtc 45423 cccatactgc catcaggatc caatctgtca ctcactccaa tctcttcctc ctccctgttg 45483 gattcattgt taggtttcct gtggcaagat gaaatggcct caggcctgta acacaatagg 45543 atcaattaca acagaagata gtatttctgt tttcctggtt gctcaagcct aaattccaag 45603 attagtttat atcaaaccta gttagttttg ctcatgtaag ggattactgc aactgggtac 45663 actaatatga agagtgggag agttggttaa gggggttctc tgaaaggaga attaggttac 45723 tgttaatggg agaatgagaa atgggtattg taatgacaaa aacacacacg actaccacaa 45783 atgttgagga agaattttcc tttatgatca tctagcccaa ctttttaatt tctaattttg 45843 tggttttgac cagttttttg tttttttttt taatgcagca tgtcataaag ttgggaatac 45903 ttcacatttt gtctttgaaa atttggagag tacttaaaaa gatttacaaa ggggaggatt 45963 gaattatttt aggaatgtaa atggtggtct tctgtctcag gcaatgtaga tgcttgctag 46023 aaaacagctg actcatgact gttttctttc taattcatta atatgaatta tttcaaactg 46083 caaagttatc tcctttcttc tcctaatcta tccacttaga gtatacatgt tcaaattaat 46143 gtattgaact aatttttcta gtaatacatt ctatgcatta caaaaatagc agtgggaagg 46203 tgaaaacaaa atgcagttat gcatttatct ctaaatgtgt tcaacatctc ttatgcgtac 46263 ttcaaaataa ttacatttgt ttaattttga aaaaaatatt aacaagaagt tgtaatttgg 46323 ggaaaattta aagctggcga aaaaggcttc atcataattg acaatatggg aaaatactgt 46383 attaaaatcc taggtttctc ccttgtttgc atgaaggaaa tgaaaaatat ataagggaag 46443 gatttaatca gtcaggcaaa aatctaaatt catcacaggt ttattcactg catactatca 46503 atgtgcccag tacctgaatg aatatattaa agaaatccac ctcttgtaca atgaatgtaa 46563 atgagcagag tgtggtgatt aaaggttggt atttggtgct gggtagaccc agctttgcca 46623 cttactgccc aagtaaatat tgccatccat cagatatctc cacctatcag acccaccctg 46683 ttgtaataac aagattaaaa tctgtatcac taaaacttta aaagaattta tagccgaatc 46743 tagaaatctt tcactataat ttatctttcc ttaaaatgtc gttttttttt caattttact 46803 atatatgttt ttgtacttgt ttgctgtctt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 46863 gtgtgttttt gaaacggagt cttgctctgt cgcctaggct ggagtgcaat ggtgggatct 46923 tggctcactg caactcccgc ctcctgggtt cacgtgattc tcctgcctca gcctcctgag 46983 caactgggag tacaggcgca caccaccaca cccagctaat tttttgtatt tttagtagag 47043 atggggtttc actatgttgg ccagactggt gttttttgaa aagacttttt cctgattcag 47103 aaggtgggac tcacaattgt aattctgcta atggttgtct ttcagtctat caattgcttc 47163 ataaatgcat ccactgttcc ttcttcttct gccctgctta taattttcca tgagtccata 47223 tatcttttta cactgtcttt agtcttattc actaaattaa aaactaattt ttgatatttg 47283 gtattcatga caagacaatt agtagaattt tgatgcttct tgtctgcaat tacagaatca 47343 atatattttc tatattattg tatattctct aaatcttatt ttgtataata gctttcagca 47403 tgttctttaa ttctgtttag atatttagaa agtatttgtt gttattctgt aatttatttc 47463 aatattcaat tatagtttaa tattttgtta tctagtgttg tcttgatttt gatatacgta 47523 ctgattttgt agatccaaat tcctctttcc tatcagagaa tgcaattttt tacttggata 47583 aataagaatc atatctcctc tgcttgctac cgtattgcat acattcatgg gtagagaaag 47643 agttaagctg atgagagtag gaattaaggt agacctgttt ggtaggttct cccagatttc 47703 agaggacaga catctttttt tccctgcctt ggtcatttaa actttttgga ttttggatta 47763 agtgtaggca gggaaaatgt atcagatatt tttatttttc tttggtgcca tttgtccttc 47823 tctgctttag gcagagaagc atatgtagtc caagaatgtg cttttctatc cagctacatc 47883 aataataaca attagtaaaa ttctacttaa acttagacct ttgctgttct cttttctctg 47943 cttgtgttaa gtcatgctca tgattctggc agttttccac agtaccatgt acagaaagct 48003 tgaataaggt acatctagaa tactcatata tgttcacttc aaaaacacat ttttgtggaa 48063 ttctaaatgc aaatctcaat agtgcaattc taatttacaa tgagaaaaaa ctaagggatt 48123 ttttctggtg attctttttg ctcatttata aatatgtttt taaatggtaa gcaaatatat 48183 aaattaagct tttccttacg tagctacatt gatttactag tggtggaaaa ggttaagcaa 48243 aactaatttt catgagtgta aatgaattag taagtgacat atgcaatgct taaggggaat 48303 ttgcataaat ctatgactga tactcaacct cttgcttagc gagaagataa ttaaaatatt 48363 ttatacttca agaagaccta gttttccaaa ttatttacat ccacaaactc agattttata 48423 gcaagtaaga aaagttaagt cagaagcata tactattaac agctacttac attgctcaaa 48483 tttaatatac gattgctgct tttgttggtt ttgaaatgtt tcttgaccat ggatctgaat 48543 aatgaagtta ttcaagaagc aactttaaga atgttatatt cttagaaaga agctatagat 48603 acaataatat taaaaaatta aatgtaagtt cctgcactca cagtagaggt aagttcaagg 48663 ttataagaga gcttatagat tctgagattt ggaaagaaga gaatagaaaa aacttttcag 48723 attaaataat gtgttaattg tgcttctaaa acagctttgg tgatcttaat aaaataaata 48783 ttgtttttat ttccattttt gcttttcaga caagaaatgc tacttgatgg ctgcatatat 48843 ttgttttgtc tcttttcacc acctactctt gctaaatact ctcaacccac tcatgaaatt 48903 aaagcacatt ggaaaacatt tatcaactac ctgtaaatac aacctatgct ctcttttgtg 48963 gaggtgatag acattcatca atggaatagt tgatctaaat cctagtcttc attatcttgt 49023 tttatacatt cttgtcttaa tcagtttggg ctgctctaac acaataccat agactaggtg 49083 gctgatgaac aacagaaatt tgtttccgac tgttttggag actgggaagt ccaagatcga 49143 attttatgtc tggtgagggc ctgtttccta attaataaac atctgttgtc tcatatgtcc 49203 tcacatgata gaaggggcaa aggagctctc tgatgtctct tttttagaat attaatctcg 49263 ttcatgaagg ctctgctctc atgacctatt ccttcccaaa gggcccactt ccaaagacca 49323 tcatattagg gattaggttt caacaaatga agccaggggg aggttggtaa acattcaatc 49383 tatagcaatg cctatctcca ggagctgcct gtggaaacac ttttatctga tatggtagtt 49443 taaagcatgg cagggataag tggtatgagg aaaactctcc ctgccaccca acgcacacat 49503 cccacttaag cttcagcagc tccaatttta tctgtgtaat atttggttcc acatcaaagt 49563 tgttttgaat atacttccat taccttaaaa aatgtaaaaa cactgcttta aaaagccaag 49623 cctattccct tttcattatt cagagttctt ccagttttac cgttacatca aattagaact 49683 acataattag gaacccctct ctaaatttgc ctctatacag agaaaaactg tgcctgaaac 49743 tttattaaaa ctcaataaag gaaatatgta tgaatgtata tatataattt ctctgaagga 49803 cagaatttgt acttcgttcc atacataaaa actcatttga caaataacaa gcatagctcc 49863 aagctcaaag aatagcttaa tttttcctga ttagtttata tctctcttat taatcaatga 49923 catttaatat tacaaccata gcttggggtt ttagtttatt tgctttctat cttttttata 49983 ctgtcggcct acctgtgccc aactatgtta tagtcagggg ttggtaaaat aaagacaaaa 50043 caaatcctgt cttcctggag atcaccttca ctgggggttg agaaacaata agaacaagta 50103 gtaagtaaaa tatgtacatt aaaattttag atgaagttaa gtgctatgga aaaaagtaaa 50163 atggaagagg tgttatggag tacctgttcg ggtatgggtt caatttacaa gtggatggtc 50223 accttctcac tgataaggtg acatttgagc aaaagtcttc agcaggaagg gagaatgcca 50283 tgcagttatc ctaggaaaga acatttccaa tataagtaac agccagtgca aaagccctga 50343 tgtagatgca taccttaggt atacgagtaa cagtaagaaa ttagtggcac gaaagacaga 50403 tgtacttgga aaccaaaaag aatctctggt aagaaattgt aagtcattgt aaggacttaa 50463 ggtttttttt tttcctctcc aaatgagatg gagatccatt agaagggttt gcgtagagaa 50523 ataatatgat ctgacttata tttaacagga ctactctttt gctgaattga aaattgtctc 50583 taagggtgta tatcagatct tatattgatc ttacccttct ctgttcaata tttaacacac 50643 aagcctgtta aatagtccat tcccaacttc tgtgacttct tgcttgagag cctttctatc 50703 ccctctcata agggctgtga gggcctaatc tgcttaccta tccagcaggc tgggaatgac 50763 acagagcact caccaggagc actctcaacc tatgactcat ggaagttggt agatgaatac 50823 cccagctctc atattccttg ggtggaagag ctctgagatg tgtgttctac accattaccc 50883 agagggcacc ctctggatta ggctcaagtt gctgacagta gtatcttgct gactaacata 50943 atttttatta attttctccc catttgacct tatttctcca tttttctaat agtgttcatt 51003 ggtatcactt ccaaaataaa ttacctttac ttgaatattt ttcttagaat cttctataca 51063 aacctgagct aatactgggg caaagagtgg aagcagggaa atattttgta ggtgttgtgg 51123 tgatgtagga cagagcctga tagcttggat caaggtggta gcaaaggaga ttgtagaagc 51183 tatcacactc tttatatatt ttgaagacac agccaagagg tttggtggaa aaatggattg 51243 tgagaagtaa taaaaagagt gggagagaaa gtcaaggatg tcaccaaagt tgtcctaagc 51303 aagtggaaac ttagatttgg gagaatcaaa aatcctaaaa tatccaaatc ctctcccctg 51363 ccttcccctc ccctcccctc cccttccctt tggagatagg gtcttgctct gtttcacagg 51423 ctgtagtcta gtttcgcgat ctcgactcac tgcagcttcg accccctggg ctgaagtaat 51483 tcttctactt tagcctccca ggcagctggg actacaggat tgcactaatg tgcccagctg 51543 atttttttta gtttttttta tttttagtgg agatgaggtc tcgctatgtt gcctgagctc 51603 aagcaatcca ccctcctcag actcccaaag ttctgggatt acaggtgtga aacactgtgc 51663 ctggcccaac attttatttt caaatattta agttttgaat gtctattcga taaccaagta 51723 aagaagtcaa ctagaatata tgagaatgga gttttctaga gaagtctggg ttgaggatgt 51783 acttttggga aatggagcac atacttggta tctaaagctg tgagccgaga tgagatcact 51843 aggtaggtaa atatagataa attagagaaa atatctaata attgagacat ggagtactat 51903 cataaatttt gaaaagacaa gaaaatgtga gagatcgaga agaatggctg gggaagaagg 51963 aatctaaggt agtgaagaga ttgaaatgtg tcaaggagag aagagagtaa ttagctcaaa 52023 tgctactgat aagtaaagtg aaatgtagaa tgaaagtcaa ccataaaatt tggcattatg 52083 gggatcatta atgaccttaa agaaagtgct tttagtgtag taatagaaag atgcagaaag 52143 taagtagagt gaattcaaat tcaacagaga atagacagag aggaattgaa gacatttata 52203 ctgacaattc cttccaagac ttctgctatt aaaaaaaata aaaaaagaag gagaaatggc 52263 aagtgtttgg aggccaattt atactcaaga ataatttctt gagttggttt tttgtgtttg 52323 tttgtttttg attggttagt gtgtttattt tttagacggg attggagaaa tactttcatt 52383 tgtgttttta cccatgtttt cagccttgcc ctggctgcct ggtataacgc aactctattt 52443 gttattctgc tattatagtt tccctagctt gaattttttt acacccttat tataattgta 52503 gcgttgcatg cctatttcaa aacatctcat gtaccccata aatatataca tctactatgt 52563 acccacaaaa attagaaata aaaaaattta aaaattatga ttttttaaaa tttgttaaat 52623 aatgtttact gactctttta tttgttgaaa tcattcattt tttggaatat caggtccaat 52683 taaatattta atcagacttt gagaaggatt taataagacc aataaataac caagtattag 52743 ttgaaggaaa tttcagatat tttggtagca gaaggaactg agttatggct caagagtttt 52803 ttaataagtg tgagtggagt tatacaaact actcattaaa atctttattt gaatttgtaa 52863 tatctgaaac cattttcata ttgaagaatc acttaaaata gtcataaaat gtaaaattgc 52923 aagacaatta aaaacaaaaa tatgatttca cgactgtgat agtacctgag aaatttcttc 52983 atctccttag taagagaagt attacaccta tttatagtta ttttatgaaa ctagctaaga 53043 tgaattatgt agaaaagata cagattttca aacagaaact agaattaatg gaagctatgt 53103 gagactataa agagtttaat agttattttg attttttttt atgagtgcaa ggagtatagc 53163 gaaaaatagc atctacctat aaggatttgc aaagccagta atctttctaa aaatatcagc 53223 aaacccagaa ttaaggctta tgttcttagc tcattgtaac tagatcaaaa ataaagaagg 53283 ccaaataaag gtatgtgaca tttgttgaaa acctgaagtg tcctatatgc agaaatattt 53343 ttatcattta attaatttca gaaacttctt aacatgacat gatcctcttg aaaagatcac 53403 atcaaaaaag gcaaaataat tgcataatta ttgtagaata atttttgtgt gagtattttt 53463 gacttagtgt aagtttccaa gttcaggatt tatcatgcag tgaaaaaaaa tacacttgtc 53523 tagaagacag gagacttcat tatattcctc tctttacaat taattaacgt aagaccattt 53583 aaaatatgcc taattttcca ggcattggtt tgctttgcta taaaatggga ggatagaaaa 53643 taactttcaa aatatcttat aaatctaaga atctttgcat cttataaatc taagaatctt 53703 tggaaattca tagattattg agatggagtc tcgttgctat gcattgtagc aaagttggaa 53763 ataaattcta aattttattt catttatatt gatcaataaa ttgttacatt tcactaatac 53823 aataaggaaa atttatttta cctgagtgta tgtctagctt gtgaaataaa aatgctcaat 53883 tatgaaagca tttattgcca ttttgaatga aaaatgtaat atgtagaaca gaattttttt 53943 tgccttgaac tcagttaaat gtagaaattg ataaggactt gcattttcat gaacttaata 54003 attatctgtc ttttcaatgg tctccatatc aagtctgaga aatatggatg tgatttattt 54063 taaacctcac catttgaagt aaatctaaag attccattag gttatgagca tataggatac 54123 aaggaccata ttgacagttt tgtgggattg tattaggata aaagggtagg aacaatgggg 54183 agaaaattat agcttacaat agggaagaac caaaaattgt tgcaaaatga tggaacaggc 54243 tgaaagaatg atataacctc ctaaacactt caaatgttta agcagttcat tgtaccaggg 54303 ccattgtagc aaatattttc tgtcttgggt ggaaggtcag tcaaggtgac tgataaagtt 54363 tcttctaacg ataaaatagc acaactcact ttttttctaa cctctaagag tatattaata 54423 tcaaaagaag gcaagcaaca aactacttct gaatgttaat atatatctgc attcatttta 54483 aaagtctgct acaactacag atagaggaac agtttgtagt atccgtgatc ctagaacaaa 54543 tttagctttt aatatcttgt caactttttt gttttagtat ctcttccttg gaactagctg 54603 agctttaatg gcatcatcat gtgatatgac ttgagattta tatttggaag agctttgaaa 54663 aatcacggat tgttacccta atgaggtgtt attcagtctt ttaaacaaga gcaatttctt 54723 tacaaaaagg agcagaattc ttaattgtat ctgtaaacct ccatttaaga atgaattact 54783 tggctgggca tggtggctca cacctgtaat cccagcactt cgggaggcag aggctggtgg 54843 atcacttgag gtcaggagtt tcagaccagc ctggcccaac acggtgaaaa acagtctcta 54903 cgaaaaataa aaaaaaaaaa aaaaaaaaaa aatagccagg tgtggtggtg tgtgcctgta 54963 atgccagcta ctcgggaggc tgaggtgaga gaatcacttg aacctgggag gtggaggttg 55023 cagtgagcca agattacacc attgcactcc agtctgggtg acagagcgag actccacctc 55083 aaaaaataaa aaataaaaaa aaaaagaatg aattgctcat aaatgtgcct cactgatgat 55143 taaatttaat cctgcaagat tatgtctttt gatggaaatg agagggttta tacaaagttt 55203 tattcgtgat gttatctatg tcatctattg atttctgctc tgattcatgt ggatgaagtt 55263 acacctcaca ctttaagctg gtgtcagtct tcccattttc tgctgtgatg tgtactcaag 55323 atctccagat tacatctgta atgtaatgca gccatgattg tttataggta catttagatg 55383 aattcaatga tgagttatgt tgtaataagt gtcagattta gatgaaccat acaaataaaa 55443 gaaccatgca ttaaaatgac aaatgtgtaa aagcattatt tgggccttaa gtcaaggccc 55503 aaatgtggat actggtactg agacatcttt cagaaaggag gtatgaagta ctgaaaaata 55563 tttacaaaat gaagactact tttatcttac ttatcatgat tcttttatta catatgcatt 55623 ttctaagata actatagtgc attagtttgt actatgttaa tataataata gggtaaatca 55683 aacaatgttt tctaaatcca ttaaaataga gttccctaag ggagttaaaa caattacgtt 55743 ctactgtata ttattggcat gcttcaggag acatgattta atctctagac tatcagaatt 55803 caagaactag tgagtcatat aacaaaggag gcttaatcat gccatttaag tgtcatggaa 55863 aaaggtttat tggtcaggaa aaattaatta gaaaaaagtt ataaaatact tcactaagaa 55923 aataaaatgt caggaagccc acttagacaa tgagtgaaaa tgaaacaaat tcaagttttt 55983 acaatatttg gtttctatag gattgcttca ttgttttggt ttttgttttt ccccataagc 56043 tgatctcaga aacttttcct ctacatgaag aggctgtcat tttttcatgg tgtgtgtttg 56103 ttcacatgcc acacagacaa tcaattatga agaaaggaga gactcgtagg aggcagggcc 56163 aggctgttca cacttttaaa ctaggtagcc acaaatgagg cttagttaca aaaacttgaa 56223 aactggattc ttcccaatgt attatacatc cccaaagaaa tgatgaagtt ccttactctc 56283 ttctctttgt ttttgtaaat cttaccactt caagtgttgg caatacttac tttaaagtag 56343 gttttcatat tggcttagat ttttttttca ttaacttgca atttgtggtt gggaaatgat 56403 ctgctttttg tttcaggttg tttaatgttt tccaatgtaa tattcttctt gcactccagt 56463 gagtttattt acaaaacatt taatgtcatt tgcgtcttcg aagaacaatg tattcggtta 56523 gaacaaaagt gagctcctgc atagagctta tgatggttta taattggtaa attattacct 56583 tggtcaagtt tgtaaactaa taaagggagt agaaaacttt tagataaaaa aaactacctc 56643 attcaaaggg accgttcacc cacaaaatgc ctttttgttt atcttttgga atgacaccat 56703 tggaaactca gtatggccac ttttatggta ataataaaag tcatatataa aaaggattat 56763 tagaaatgtg ttatttctta ggcaggtatg cttatttaaa gtatgtatgc atacatactt 56823 taaactacta aatacaaata aattagtagt acagtcatta ggattgctct tagtttgtta 56883 gtgttggaat agacttttgg attttcttcc tagcttagat tgatacaatg tgatggggac 56943 ttgctctcca aacacaggaa taggtggcct gcagacacac tctgtgatgc tgtaattcta 57003 atcctcactg aatatatcag gggtggacat ctggcctggg gcaattcaga tactttttct 57063 taaaatttat actacaaatt caaaagtggt aactcatctc tgccatcact tatagtagaa 57123 taagacccac tgttgcagtg gggaattgag aaacccagtc cacagggaga acaaacatgg 57183 agaataaaat aagtaaatta gaacaggaaa aatgccaaaa cacacagaca tgaccctgat 57243 agttttccat ttcctgatca ctgtcccttc ctgtggctgg ataaggaact gtctctaggc 57303 tctgtaagac atatttgcat ccttacgaca aatttctact ccttttcata aactagactt 57363 gggttcttta acttgcaaca gcaacaacaa taaacgattt tgttgggtac aatctgattt 57423 tattaacttc tggatttaaa agcccttcta aatgttgatt ggcattgttt ttacttccta 57483 agagtacgct catgcaccac atagtgatgt tttggtcaac gacagactgc atttacgact 57543 gtggtcccat aagattataa taccatgctt ttctgtactt ttctatgttt agatatgttc 57603 agatacacaa atgcttatca ttgtgttata attgcctaca gtgttcagta cagttacatg 57663 ctgtacaggt ttatagccta ggagcaattg gctataccct atagcctagg tgtgtagtag 57723 gctataccat tagatttgtg taagcatacc ctatgatgtt tgcacaatga tgaaatcacc 57783 taaggatgca tttctcagca tatatcccag tcattaagca aagactgact ctattattag 57843 gtctatttta ttctatagca tttgatcatg agatatgtga aaataaatat aatttttaga 57903 agtacaataa ctttcaaatc ctgaatgttc tgtactttcc atctcacaag cattttgcaa 57963 agcatcaaat ggtataagcc agattactgt taaggcaact tggaattaat atgctgctca 58023 gttctggaaa aggcatattc tgtaaatata gatgagagaa tatagacttt ttccctctct 58083 tcttacaatc cacattctat tcagtatttc atttacttga ggggttatat gctacttatc 58143 tttatctgtt gtggagtgag gacacattcc aaatgccttg gtattattaa aagcccttca 58203 tgatgtggcc ccatctttta tgacttttcc ttttcaactg tgccctctag ccttatttga 58263 tttctctcaa attcttaaac acagcatgct tcactgacct ttaagccttt gcacatacag 58323 tgttgatgtg gagcttcctg accaactcct aattctcctt caggcctcaa tttaaacatc 58383 acttcctctg ggaagctttc tattattccc aaggtactgg gatatgttct tgcacagcat 58443 gctgggctaa tgtcacaatg gctaccttgt tttattgtta gtatttgatc agcgacacct 58503 tgccagggag cccctgagta ttgtctgagc agaaactatg gctatcttgt cccctgttta 58563 gcacagggct tctctaaaag tgggcttctc taaaagtaag tgctcaagaa caacaacaaa 58623 aagtgttaca ttaataaaca cacacacata catacaaaga aatacctgtc tttctccata 58683 tctcaagatc atgctgaaaa gccagcattc atgaacaaat tcctgtgcga agattgagaa 58743 tgaaagatga ataagaggta tctttagaac ccaattatgg ctgccgttgt tccctgagtg 58803 tgaggcttgc tgttagagtg acagaaggaa ttttgactac tcaagaccat acaaatttgg 58863 aaatgactcc aaagtaaaca tggttagata actacacatt ccattccccc ttttttattt 58923 ctatagaatc ccaactttgt tcaagtagta acatgcccag cttcagaaat gagtcatgat 58983 ttttctaaag caacaatatc aatcttcttt cccttcccca gtgattggta tggaagtgga 59043 catttcagca agttttagcc aataacgtga attctgtttt gaagcatcta agaaagattt 59103 tgctttctgc tgtaaatcaa aagcagaaac aggagaagat tcttttgggc ctctttccct 59163 cttcctggcg tggaagtagt tgtgagagca tatgataccc aaagtttcgg tagacatttt 59223 ataattatgt gatgaataac ctaaggataa ttaaacatat aaaagaatgg agaaagactg 59283 agtctgtttt actccacaag atgctgaacc aaccctgaga cataatttat ctggattctt 59343 aaataactag tgtctttgtg gtttaagctg ttctttgtaa acaaacatat cataagtgat 59403 taagtgatgt tatcttcctt taaggcaatc aaaatgcatc tgacaaatgg ccatctaatt 59463 taaaattcca actatgtaga catctcaaac aaagtcagta tctcaaaaaa tatactacaa 59523 aaattctcat gtgtccattg gggataactt ccaatgctct ttcattggta ttgtagctat 59583 ggcatttgat ttccaattgt atgtggatca ggtagttgca gggtgactct caagggcgag 59643 aagaaagtaa gagtacatga aaaaaaagag gaagagagag agcagacaag aaggaagaac 59703 aagacaaagt caaaccctag gtagaaataa gaaggagcta gtacagaaag caaatgccta 59763 aggtgttgga gaacatagaa aggtagagtg gaatgaaaaa gaaaaaaaca ctaaatagca 59823 gcacatagaa tcttggggtt tcagggatat tgtttatgaa aggttagaat aggcaacaat 59883 ctaccttgtg gcatcttctt aaaattatca acatataaaa caaacaataa ttatttaaat 59943 tacctgtcat atgggtcttg tcatttattt ataatttaag gagaattaaa actgaactag 60003 ttgctgggga gtgacatcag caagatggag atatagaaat cttcaggacc tccttccgtc 60063 catggaacca ctgactcaaa aatgacaaat ggaaaaaatt tactttctga gaaatcaaga 60123 agccagttaa gaggctcctg tatctcagat gagtgcaaag ccagctgcaa cagagccagc 60183 agaaaatttg ttgtactcac tcttcatggt cacttctggc atagcacagt gcaatctaga 60243 agaaattctc ggctcctgac tactttcttg gaaaagaaag agaaaaatgt accatatgtc 60303 taatattctg atggggatgg ggtgtgggct gctcaaagga ctagcttccg tcatgcctaa 60363 atacaagtgc taattgggaa gtccacaatg ttgggggctg cagaaaacaa gggcaacagt 60423 ttggactagc atgcactcat ttgccgcagt tcctcctctc acttcataga atgagtagaa 60483 gaacccttaa ctctcaaggt ttttttcctg gggagagaaa gagtcaaagc aattatacaa 60543 tattatggct ttgtgggagt gatgtatcca aaaaaaaaaa aaatgagttt ttaccacacc 60603 aatctcagag tgcagatgga acctagcata ttctagatgc ctgggggcca ttgagaacaa 60663 aagagagcta ggcaactttc agcagctcca gaagaactgt ggtaccacag atagacacca 60723 aagggaggaa gagattacaa gctcctgaaa aaagaaatga gcaattcatt ctaattgaga 60783 atttacacac actggtacag ataagatgaa tttgcaaaaa aagaatagag gccccagaat 60843 ttctagctgg gttttttggt gaaggccttt ctctgtatca agctagtccc taaagactgg 60903 gtgaggtggt ttttgtttgt tttacatttt tattttaaaa gatggggatc tcactttgtc 60963 acccagactt gagtgcagtg atgcaatcat aactcactgc agcctcaaac tccaagggtc 61023 aagtgatctt tccacctcag cctcctgagt agctgagact agagacacat gccactgtgc 61083 ttgattaatt tttatttttt tatttttttt cgtagagatg tggtctcact ttgttgttca 61143 ggctggactt gaactattga cttcaaggga tcctcctgac tcagcctccc aaatcattgg 61203 gattacaggc atgagccacc atgcctgacc tgttttgttt tgttttaaaa aactcagaaa 61263 aatttcaaaa tagcaattat aaagacaatg agcttagaaa accaattaat ggacaaaatg 61323 taactataag taaagagata catgtaaaaa gaatcaaaca aaatttgcag tggaagaata 61383 tgataaccaa attgaatatt acattagagg agtttaatac tagatttgaa caagcagaag 61443 aaagaatcag ggaacttgaa gatgggtcat ttgtaattat tcagtcagag aaacaaaaag 61503 aagactaaaa aagagtgaag aaaccctaag gacatcatca agtagaccaa tatgtgttat 61563 cagagtttta gaagaaaaag acagaaaaat aggcataaag catcattgac aaaataatga 61623 cccaaaacct cccaattatg aaagacaata gatattctga atccagagca caatggcctg 61683 caactaagat gaacccagaa aagtctatac ttcagcacat tataatctaa ttatcaaaag 61743 ccaaggacaa agaaggaatt ttgaaagcag aaagaaaata gtgactcatc agatacacaa 61803 gggctgtcat gagaatatca gcagatttct cagcagaaaa cttgcaaaac agaaataagt 61863 gggattacat attcaaagag ctgaaaaaaa gtctgccaac aaaaaatcct ttatccagaa 61923 gaattttctt caaaatgaag gagaataaag gatattccag ataaacaaaa gccaagggaa 61983 tccatcacaa ttaaacctgc cttacaagaa atgctaaatg aagttgttca agttgaaata 62043 aaagaacgct gaacagcaac acaaaagcat ataaaagtat aaagctcatt ggtcaaagat 62103 agatataaag gaaaaacaac gggatattat aatggtggtg ggtaacttac tcttcatcct 62163 ggtatagaag ttaaaaaaaa ccacaagtat taaaataact gtaactataa aattattaat 62223 gaatacacaa tgtaaaaata tgtaatttgt gatactgata acataccatg tgtggagggg 62283 agaagtcaaa gtgtagagtt ttaaataaga ctgaggttag gtttttatca ccttaaaata 62343 gattgttata atatgtttga tttaagcccc atggcaacta caaagaaaat acctacaggt 62403 aataaacaaa agaaaatgag aaagaaatga aagtgtgtct cagtccattt ttattttgct 62463 ataactaaac atctgagact aggtcattta tagagaaaat aaatttattt cctgcagttc 62523 tggaggctgt gaagttcaag actgagttgc tgcctctgtt gaggggcctt cttattgcat 62583 cataacatgg cagaaggcat cacatgacaa aaaagcaaca gcaagagcca aactggcttt 62643 tatcataggc ctagtttgtg acaccttaca tagtcctatg aaaacccatt aagccattag 62703 cccattaatc cattaattca tgaatagatt aatacatcca tgtggggaaa gccctcatga 62763 ctcaaacctt tctcaaaaaa cccatctctt aatactgtta cattagtatt aagttttaac 62823 atgagtttca gagtctagaa atattcacac catagccttt cacccatgac ctcccataat 62883 ttatgtcctt atcatatgca aataccttca ttccattccc gtagccccga agtcttaacc 62943 tgttctagca ccaactctaa aatacgaagt caagagtctc atctgagact caaggcatga 63003 tccatccttg ggcaggttcc ctttcagttg tgaaatcaaa acaagtcata taattctaaa 63063 atacagtgct ggtacaggaa taagacagac attcccttgt cgaaagggaa aataaactag 63123 aagaaggggt taatggtccc caagcaagtc tttaacacag cagggcacat attaaattgt 63183 aaagctaaag aatactcttt tttgggtcca tgttaagcat tctctgcaca atgtggggaa 63243 cacattgagc cactctgccc ctatggcttt gctgtgctca gaacacactt cagctttctc 63303 agattggaat tgctcattgg tgcctgcagc tttcccaggt gggcactgca cactgctggt 63363 gtttctataa ttctaggatc tcaaaggcag ctctggctct caccccgtat ttttactcaa 63423 cattgctgta gtggggctct cagccatggc tctgtccctg tgacaagtct ctgcctgggt 63483 ccccatgctt ttagatacat cctctgaagt ctaggtgaag gccatagtgg ccctacaact 63543 cttgcattct gtatccctgc agaattagca ccaggtggac actgccaagg cttatggctt 63603 ttgctttctg gagcagtgag gtaagctaca cttggagcct cttgagccag ttggagtggc 63663 tgaggaatga tgcgctcaca tgaagggagc agaggagtcc tgagcagccc tgggcagcaa 63723 gctgtggaga gtaccctggg cctgtcccct gaaactattc taccctcctt ggcccctggg 63783 cttttcatga gagggggcag tcttaaaaat atgcaaaata cttttcaaac attctcctca 63843 ttgtcttaat gaataacatc tgactccctt ctatcagtgc taatctcttt agcaagcagt 63903 tttgctgttt acatggctaa gcaagctgca aacttttcaa atcattttgc tgtgattccc 63963 tttaattata catctgtctt taagtcatgt ttttgctcct gaattggcca aaagtaacca 64023 cacagccaaa agtagccaaa cagcatcatg aatgctttgc tccttaaaaa tttcttctat 64083 aagatatttt actttattat tgtcaagtct ggccttctac acagccctag agtatggaca 64143 cagttccagt aagctttttg ctactttata ccaagtatga cctttattcc aggttctgat 64203 accttgttcc ccctttctgt ctgaaacctc ataacggcct tcattgtcta tatgtttact 64263 agtattttgg ccataatcac ttaaataatt tataaaatga ttcagacttt ccctagtctt 64323 ctcatcctct gatccttcac cagaagcacc cttaacactc tatttacagc aatataagat 64383 tttttttgcc tgctcctcca aacccttcca gcctttgtcc attacccatt tccaaagcca 64443 cttgcacatt tttaggttga gcatcagcct cacttcttgt taccaaagcc tgtattaggg 64503 ttctccagag agacaaaacc aatgggatat acagaagggg atttgttagg gaaattggct 64563 cacacagtta tggagactga aaagaccaag gtcaagggga cgtatctggt gagaaccttc 64623 tcattgtatc ataacatggc agatggcatc acatgctaaa agagcaagaa caatagccaa 64683 actggatttt ataacagacc cactcttgac gactatccta ttcctgtgat aagccattaa 64743 tctgtgaatc catgagtaaa ttaatctatt catgagggct ctgcctctat tgtcccttaa 64803 aggccccact tcttaatact gttacattgg ggatgaagtt tcaatatggg tttcagagga 64863 gacaaacatt caaaccatag tgatgtcact acaaaaaaat taatgaaaca caaaggagta 64923 cagtaagaga gcaaaataca gataaaagtg ctatatgata tatagaaaac aataaaatgg 64983 caatagtagg agtttatctg tcagtagtta ctttagccat aaatgaacta aactcaaaca 65043 aaagacaaag attagctgac tggatttaaa aaatactata tgctgtctac aagaagtaca 65103 aggagcccac tccaaatttg tagacacaca taggataaaa ttaaaaggat ggaagaaagt 65163 attccatgtg aatggtaacc agatgagagc agggctcatt atacttatat cggacaaata 65223 aattgtaagt caataattgt cacaaggaac aaagaaggac aatatgtaat attaaaagag 65283 tcaattcacc agaaagatat aacaatttta aacatatatg tattcaatct tagggcttta 65343 aaatatataa acaaatatta atggaactga agggagaaag acagcaatac aacaatagta 65403 ggagatttta attctcagct ttctttttct agagacagag tctcactctg tcactcaggc 65463 tggagggcaa tggtacaatc tcagctcact gcaatctcca cttcccagac tcaagtgatt 65523 ctcccacttc agcctgctga gtagctggga ctgcagacat gcaacaccat acccagctaa 65583 ttttttaact ttttgtacag atgaagtctc gtatattgcc cagctggtct taaactcttg 65643 ggctcaagtg atccttcacc tgggcctccc aaagtgctgg gattataggc atgagccacc 65703 gtgctcagga cccaactttc aaaaattgat agaacatcca gacagaagat caatgagaag 65763 cggattgaac aacgtagacc aaataagcct aacaaacata tgcagaaaat tccatctaac 65823 agcaccagaa tatgcattct tctaatgcac acacacatat tatccagaat agatcatatg 65883 ctgtgtcaca aaacatgttt taacaaattt aaaaatacag aaatcatatc aaatatcttt 65943 tctgaacaca gtggaatgaa actataaatc aattataaaa ggaaactggc aatttcacca 66003 atatgtgtac attaaacaat aaattcttga acagtccatg agtcaaagaa gaaattataa 66063 gggatatttg aaatgtttca agataaatga aaatgtctca agatgaaata aaaagacaac 66123 atatccaaat ttatggaatg caacaaaagt ggcaagagtt aagtttatag tggtaagtga 66183 ctacattata aaagaaaaaa gattttaagt aaacaaccta actttacacc tcagaagtgg 66243 aagaaggaga aaatactaag cctaatgtta gcaaagaaag gaaataataa aaattagaaa 66303 aaataaatta aatagaaagt agaaaattac tataataatt aatgaaacta acagctgctt 66363 tttaaagatc aataaaattt acaaaccttt ggctagaata actaagaaaa aagagagaag 66423 actcataaat aatattgtaa ataaaaaagg agctattgca atcaaagagg caggaacaat 66483 aaagattttc aggctattct gtataattat acactaacaa attggataac ctagaagaaa 66543 tgtataaatt ctcagaaata cacaacctac caagactgaa tcaagaagaa atacagaatc 66603 tgaacagatc tgtaactagt aaggagatta aatcaatgat cagaaacttc ccaaaaaaga 66663 aaatcccagg atcagaaaac ttcactggag aattctgcca acatttaata gaaaaaaaaa 66723 tgccaattct tctcaaactt ttgcaaaaaa ttgaagagga cgaagcattt caaactcatt 66783 ttatgagtcc agcattttcc tgataccaaa atgagataaa gatattacaa cgaacacaca 66843 cactttcaaa caagctacag gccactatct ctgatgaatg taaatgcaaa agttgtcaat 66903 aaaaaatagc aaactgaatt caacagtgca ttaaaaggat cacacactgt gaccaagttg 66963 aatttatctc tggaatgatg aatggtttaa catatgaata tcaatcaatg tgatacacta 67023 tattaacaga acaagggata agatcacatg ataatctcta taaatgctga acaatcattt 67083 gacaaagttt aatacccttt cgtaataaaa atactcaaca aactatgaat agaaggcatg 67143 tacctcaaca caataataaa ggtcacatat caaaagctaa cagataacat catactcaat 67203 ggtaaaaact gaaagctttt cctccaagat caggaactag gtaagaatgt ccattcttgc 67263 catttctcat caacgtatta ctagaagtct ttgctagaac aattatgcaa gaataagaaa 67323 taaaaagcac tgaaatcagc aaggaagagg gaaaattatc tctattccca gatataataa 67383 tcttatatgt agaaaattct aaaaatcaca caaggaaact gttgcaacta gtaagttcat 67443 caaaattgca gaacataaaa tcgaaatgca aaaatcagtt atgtttctat acaatagcag 67503 caaactctct gaaaaagaca ttacaatccc acttacaata ttatcaaaaa tgactaaaat 67563 gtttagtaat aagcttaacc aaggaggcta acgacttata cactgaaaac cataaaagca 67623 ttaccaaaaa ataattttaa aagacacaaa taaatagaaa gataattctg ttttcatggg 67683 ttagaaaact cgatattgtt aaaatgtgca cactgctgaa agcaatttat agatcctata 67743 caatcttacc aaaattatga tgtcattttt ttcagaaata gaaaaaaaat ctgagaacca 67803 tggatactta gaaaatctgg agaaagaaga gcaaagtaga gggtctcatg cttcctgact 67863 tcaaaacata ttccaaagcc attgtaatag aaacagttta gcactggcat aaagacagat 67923 atatgaactt acaaaccagc atagcgagcc cagaaataag cccacacata cattgtaaaa 67983 taatatacaa agcacaaaga ctatggacag gatagtctct tcaacaattg tgttgggaaa 68043 actagatagc catattcaaa ggactgaaat tagaccctac tcaaaaaatc aagtcaaaat 68103 gaattaaaaa ttaaagatct gggccgggcg tggtggctca cgcctgtaat cccagcactt 68163 tgggaggcca agggggtcag atcacgaggt caggagatcg agaccatcct ggctaacaca 68223 gtgaaacccc gtctctacta aaaatacaaa aaattagccg ggcgtggtgg tgggcgcctg 68283 tagtcccaac tactcaggag gctgaggcag gagaatggcg tgaacctcag aggcagagct 68343 tgcagtgagg tgagatcacg ccactgcact ccagcctggg ggacagagca agactccatc 68403 tcaaaaaaaa aaaaaaaata caagatctga aactatgaaa ctcatagaga aaaacaggag 68463 aaaagtttta taccattggt tttggcaata atttcttgta tacgacacca aagaacaggc 68523 agtaaaagca acaaaaaata gataagtgga actacataaa attaaaaact gatgcacaga 68583 aaataaataa aaagaaaaaa cagagtgtaa aagcaaacca tgaaatggga gagaatattt 68643 gcaaaccata tatctgataa tgggttagta ttcaaaatat ataaggaaca cctacaactc 68703 aatagcaaaa aactaaccca attaaaaatg gacaatggac ctgatggata tctctccaaa 68763 gaagatgtaa aaacagccaa cagatacatg aagagtgctt aacatcatta gtaattaggg 68823 aaatgcaaac caaaccacat gagctatcat cttacacctg gtaggatgac cattatgaaa 68883 caaaagaaag agaattaaaa aaaaaaaagt gttgaaaggg atgtggagaa actagaacct 68943 ttgtacagcc actgtgaaaa aatgtttgga agttcctcaa aaaaattaaa aataaaacta 69003 tacgatccag taatcccact tttagatact tttccaaaat atttgaaaac aggaactcaa 69063 agagatattt gcactctcat gtttattgta gccttattta caatagtcaa gaggtggaaa 69123 caaatgaaat atataatgac agatgagtca ataaaatgtg gcatgtacat atcatggaat 69183 attattcagc attacaaaag aagaaaatct tataatatgc tgcaacatag acaaaccttg 69243 aggaccttat actaaataaa ataaaccagt cacagaatga caaatactgc atgaatatac 69303 ttctatgaag tatctaaagt agtcagtcat agaagcagga agcagaacgg cagctgccag 69363 gtcctgggag taagagtaag aggaaagttg catttcagtg ggtatagagt ttaaagcatg 69423 caagatgaaa aagctctaaa gatctgatgt acaataatat gcatataatg aacaatattg 69483 tactgttcac ttaaatatgt gttaggtcca tgttatgtga tttttaccac atttttttga 69543 aagcaagttg ctaaagaatt tgccaaatgg aattatagtg acacgagttc aaataaaatt 69603 aaaaaacgag aaacagtaga gtttacttaa tttgttaata tatccatatt atcattttag 69663 ggaattttta ctaaagcaga gtatataaac tatctttttt tgttctaatg atccatttgt 69723 tttagtttgt ttcccatttt tatgtagcta gactgccagt taatctccta aaattattgg 69783 caccatattt cccatttttt ctggcttttt tattagtaac tgggatcctt gcagctgtat 69843 ctatgtgatg ccaaacaatt aggttgatca attctgtgac aacaagccat ctggttactt 69903 tagtgaatag gcccttactt acctttcata agttgattct attctccttt gtgccttctc 69963 tttaaattac cattatcctg taaccataaa ttaaaaatac agcatcgctt ttaaaacatc 70023 ctgaagtaat ttttaacact acaaaagaga agaaatttcc tttgtttggt gttctttgac 70083 cctaattagc atttaggaac aaactacact tgcaaaatta ttttcgattg gtagagggaa 70143 gaaaagggtc tttttattac tatgtatttg taattacttt tgtcacttat gttattcttg 70203 tgtctaaatt caactctaga tttattctct gttgatattt tttatcactt gagaatattt 70263 tagtttttca acctctatat ggcgggctat cactccaaat ttaggttaaa ctgtaggttg 70323 atttaaaaat ctggctatga tgcagaaaaa ttcgggcaac ttacctagaa aaaaaaaagt 70383 agttatattt cagtacttct tttacctaat cagccatttt aaaataattt tgttcattat 70443 caatatggag gaaattattt atatgcaggg aagttattta tatgcagagc tgttaatggc 70503 agcaatctgc atgacaaatt tctacttaat aagcaatgaa atagttggat aaatgtgtat 70563 ttctacatgg gtgaatttcc caaaattcac acttcaaaga cagttgctga cattttttca 70623 atgagagatt ttattagata atgagtcatc ttagagttat cttgtaagta ttctttagtc 70683 ttaatttaaa tttaaatgaa agtcaattca aagtgttgta ttttcttaaa taaattttgt 70743 tttataaaca ttagaaatta aataggacta ccatatggtc tagcaatcac acttctgggt 70803 atatatccaa agaaaatcag ttcagtatgt caaagagatg tttcgtattc attgcagctt 70863 tattcacaat agccaagata tagaatcaat ctaagtgccc atcaatggat aaacgtagaa 70923 aacatgggct gggtgcggtg gctcacgcct gtaatcgcag cactttggga ggccgaggcg 70983 ggcagatcac gagatcagga gatccagacc atcctggcta acacggtgaa accccatctc 71043 cactaaaaaa aaatacaaaa aaaattagcc gggcatggtg gtgggcgcct gtagtcccag 71103 ctacccggga ggctgaggca ggagaatggc gtgaacccgg gaggcggagc ttgcagtgag 71163 ccgaggttgt gccactgaac tccagcctgg gctacagaac gagactccgt ctcagttaaa 71223 aaaaaaaaaa ggaaagaaaa cgtggtatat atacacaatg gaatactatt tagcctttta 71283 aaagaaggaa accctgtcat ttgcaacaac atggatgaac ctgaaaaaca tgttaagagg 71343 aacaagtcag gcacaaatac ttaatgatct cgcttatatg tgaaatctaa aaaagttgac 71403 ttcatggaaa tatagagtag aatggtgatt atcgggtgct gggagttggg gtaagatgtg 71463 gttggggaaa cggtcaaaga ataaaaaatt tcagttaaag aggaagaata cattcaagag 71523 atctattgta catgttgaat atagttagta acaatatttt gtatcctcaa attgctaaga 71583 gagtagattt taagtgtttt tgacacaaaa actgataatt atgtgaggta atacattttt 71643 taattagctc cctttagcca ttccacaatg tatacatctt ttaaaacatc atgttgtaca 71703 tgacaaatat atacaatttt tatttgtcaa cttaaaaaat attaaagatt taatgtagat 71763 aaatgaaaga aaattaggaa ttaaggtaca aaaattattt atagtgttta ttattggtct 71823 atgtttacat agtatttctt tgtctccatt agtgtgttat acaaataccc aactagaaac 71883 atgactttac aaatggtgta tctgatcttt tatgtcccta gttattattt tagccctgtc 71943 ttttttttta ataaaacata ttctgctttt tcttgtcctc atccttctat gagttgaatt 72003 agtgactcta ctccaaagta atggtgttgc tttctcagac catatggtga tacaaaggca 72063 tatgagttat cataagcatg gtctgtgtag gcaaagcatg taactccaca aatgcttctt 72123 gagagattct aatataatct gtgccagacc tgcacaaggc atagagaata aaaatttgca 72183 ccccacacag tcactcctca ttcattcatt caacaataat caagtacctg gtaatgctaa 72243 tgcagtgtac tataattcca tatacataaa ctaatatttt taagatacat gaaggttatg 72303 ttataactaa tagtcaatgt atttttaaaa ttactgtaat caaattgtaa ttgtaattaa 72363 gtattttctt aatcaacaga aactaaaagt ataatttcca tcaactcctt ttaagtataa 72423 atgtaattaa atgcctggca cattcttcac attatataag gatctttata cttaagacat 72483 ttgggaaacc ctacttaggc ttatcattga caaaacattt tcaaaatctt ttcatttggt 72543 cctcaccaca atactgttaa aaagacagcc taagctgttt tgtgcttcct ccctagttgg 72603 gcatccctgt gcaatgagag ggacaaacaa ggtggtttta aggtcagaaa catccaattg 72663 cagcatcatt gggaaatttg taagagcagc ttttataaaa tgtcaccaac tcatgtatct 72723 ttaaaagatg tgctgaatct tatgccttga gatttttctt agtttcctta ttttctattc 72783 ccctcccact ttctctttgt cccttggtgg cttcattaat cccatattac aatacaaagt 72843 aaataatagt gctctgaagt gcttcctatt tgttcaggat gaagtctgaa aaatgaaact 72903 gcaatttttt ttcttttgag acaaagtctc actctgttgc ccaggctgga gtgcaatggt 72963 accatttcag ctcactgcaa cctccgactc ccaagttcaa gtgattctcc tgcctcatcc 73023 tccccagtac ctgggattac aggcatgcac caccacgcct ggctaatttt tgtattttta 73083 gtagagatgg ggtttcacca tgttggccag ggtggtctcg agctcctaac ctcagatgat 73143 ctgcacacct tggcctccca aagtgctggg attacaggtg tgagccactg agccctgcca 73203 aaaactgcaa ttttatctta ggggacaggt aagcataaaa acatccaaaa tcatgtattt 73263 atgtttaggc tctgcttgta gagtgatacc aaattccagg tgtttttttt tttttttttt 73323 ttttttgaga cagagtctgg ctctgtcgcc caggcctgga gtgcagtggt gagatctcgg 73383 ctcactgaaa gctccgcctc ccgggttcac accattctcc tgcctcagcc tcccgagtag 73443 ctgggactac aggtgcccgc caccacgccc ggctaattgt gattctttac attatcaaag 73503 aattcatgaa aacaggatat gaagattagt gaaggattct tttcattagc aaagtaactt 73563 ttcttatttc aaatttaaca catctattta taaaagttat agaatttaaa ttttaaaata 73623 tgaatgaaga aaaacaaaat cagcataaca tagtaataca tataattgat atgtactatt 73683 ctgttacttg gattcattac ttaacccttg cagtattcta tgattttttt ttaatccatg 73743 tgttacagtt agggcttaga aagatttaag cacctagcca aaattatgca ttatgttaag 73803 tggttgatat ccacttattg acaaatatgt attgattgag aattagtcat ggagatatca 73863 atgggttatt ttgattactt tttccattac tcccaagtgg tcaggattag ttttagatta 73923 tttaagtagg ttggctgagt tcacaaaagc tattactatg gggaccttaa ttgaaatcta 73983 actctatcca attctatttc ttttccctat ccctcgaatg ggtgtatgtg tgtgtgtgtg 74043 tgtttgcaca cataaaaacc tgttctaatt ttatgcaaca tggaaagcat taatgtttaa 74103 catgtatgtt tgaacaggga attttgtact gcattaaaga ttattcctgt gtattacata 74163 caatcaaata tttgactatt gactgtctta gtatgttcat ctaattgttt cctattccca 74223 tgaaaactgt atcagtctga gaacagctac tatatgatat gcatcactag tctccccatg 74283 gtgcataata cttgatataa attagatgct gttggttata cttggcgggg ggaaagggga 74343 cactaaaaag gaagagtcaa tttctactgt gaacaaagca aaaagcaaaa ggagagataa 74403 atggaattaa attaaaaatg aaattgagag tgtagataaa tctatgtaat gaagatgcta 74463 gtaacatagg aagagaaata agatagggta taacagtgat tatttttcct aataagtagt 74523 gtcatggcag ttggaagaca agagattatc caagcactgg ttatagtctg aaagatgagg 74583 tggtagctta cttgtttggg cctcaggcat tgcagtacaa acagacagtg agggaggagt 74643 caattaagac ttatacaaat gcagaagtca tggttgaggt agtgagagga tttccaggac 74703 agtgatgaat aacagaacct cagcagaagg agcatgtgga cccaaagcat catacgaata 74763 atgataggac caagggaaaa gaagtcaagc ggaatgggga tagacaaaag ttttgaaatt 74823 tatgtgtaag agttgaatga agaaagttat taataagact tacacaacaa agaatttcta 74883 catagaagtt gaaaagacag caacagagtt tagagtttag gaaaaaaaat taaatattaa 74943 attttaatat gtaatattgt aggatttgaa taccttaaag ctgaaattca gtttttgatg 75003 ctgcttctta gcatctttgt cttgacatgt atatcaaaat gtaagaatgt ctgtatctta 75063 caatctgtga ttcttgagaa gtcaatgcca tattattcac tacattcatt ctttcttatt 75123 ggaaccataa tactttcttc aataataatg tcagtagaca ttctaaataa ataaaaaata 75183 tccaataaca tgccccaatg tttcacaggt atcacaccaa tagcccctga gatattgtca 75243 cattccattt atctgcagaa gtcttattca actttctgta ttaagtacca agaaatttct 75303 taggcaatta gtaagttcac ttgtattctt aaaacttcac agaatgaaaa attaaaaatt 75363 ttaatctctt tttctagaac aattgtttta caaagacttt tcaaggtttt ttaatcctat 75423 tttttgacaa aataacatat tttaatgaaa gtaaacatgt agaaatgact taaccaaaac 75483 tagctattga caacttttca gcactttttt ttgggtgaat tcaggaacaa actttgtatt 75543 cattttatta atccactaag tagggttgct tcacttcctt ggttactgtg catgtggacg 75603 aggctgattt tcatggtggg atgttaaaag gagggatttt tgcaaatcaa accacagaac 75663 catcacctca cacttgttag gataacaaac attagcaaaa ccaaagatga caaatgctag 75723 caaggatgtg gagaaattgg aactcctgta tatgctgaca gaaatataaa atgatgcagc 75783 cactataaaa attttttgtt tttgagaatg tgtcttgcta tgttgtccaa gctggcatca 75843 aactccaaga ctcaagtgat cctttcacct cagcctcctg aagagctgga actataggca 75903 tgaaccactg tgctggcttg gaatattttt attttcctca aaaaatcaaa aatagaatca 75963 ccatatgagc cagcaattcc atttttgggt atatatccaa aataatttaa atcaaaatgt 76023 tgaagagata tctgcactct cacattcatt gcagtagtct tcacaaaaca acctaaatgt 76083 ccatccatgg attaatgggt aaagaaaata tggtctacac atacaatgga atattattca 76143 gccttaaaaa agaagggtat ctttctgaat gcaacatcat agatgaacct gcaggacgtt 76203 atgctaggtg gaataagcca ggtatagaag gacaattatt gcatgattct acttacatta 76263 ggtatttgaa atagtcaaac tcatggaaac agagactaga atggtagttg ccaggggctg 76323 ggaggaggca gaaatgagga actgctgtcc aatgagtatg tagtttgaat tatgaaaaaa 76383 tgaataggtt ctagagatct gctgtacaac attgtgccta cagttaatga tgcagtatta 76443 tgcacttaaa catttatcaa gagaggagat gccatgttga gtgctctttt cacaatgaaa 76503 gtacagtaaa atgaaatgaa atatacagca ggctttacac acaccgcttc acaggcaaaa 76563 actacttggg aaacaaaatg gaaggtcccc agagtcgtga gggaagtaag gtatggtaca 76623 gggtcaaaat ggctgtacct ggagctctct gactggtcag gcaccaacca gcaatactct 76683 catgccttaa ttatagttta ctgctgagat aattgagaat gagagctcat atttactaac 76743 caggatatga atagactgag aactttaaat aactttcctt taattccata aaaatctcca 76803 ttctgtttta aagtctttag tacagatttt agatgtaata aactgctaag atttgagcaa 76863 caactataag cataataaat ggtttgcttt atgggcagtt ttacactaat gcctctaata 76923 ataataacag tagcaataac aaaaatgaca ggattcttag gacttcatta ctcagagcat 76983 aatccctaga aagcagcagt cattatctaa cccagaaact cccaagagtt tgcttaacac 77043 tttaaaatgt ataatctaaa ttaaagaaaa tatgagtaaa tggtattgtt tcccctgaat 77103 tgaagtaata tgggatgtgt tgaaagaata catcaagaca tttttcactg tcacctagcc 77163 tgatgactga catagattaa ttactacata aatttcctct tccatttaat actgataaac 77223 agatttatgg gacttaaacc acagtacaca gttttgtatt ttgtacgaaa tggataatca 77283 cattttaaaa catgtgtaag gcatatttgc aaacttgaaa cgtcgtcttc cataaatata 77343 tgctgaatga atgaattaat gaataaaaat tgaggcaaaa actcaggtgt ggctcagtca 77403 tctgaatgtt attatccaat gaaacaggtc aaagattttt tttttttttt acggttcatt 77463 tctagccaat aagaccaagg ttcattcact tcacctctgt atagaatcct ttgttggggg 77523 ctgcgaggag gcagtaagaa gtatcacatc taatcttttc cataattagc caagttagtt 77583 ggtacttccc ataactctga tacccatagg cccttgctat ttctagactt gagtgtcatt 77643 cagaaatatg gtttaggcga gcactaggaa agatacacag tttttctaaa acacattatc 77703 caatcaatat tctacttata aaagtcaact acacacactt cagtcatgag gtaaaaaaat 77763 gaaatttata cataacactc acttatgttt atcactcact tatatttata ataatagaca 77823 tacaggtatt ctattaaagg aactttttaa tgtttgacca gaaaaaattt caatatccct 77883 ttttattaag tttaagttac tgtaatgaaa ttaaacatgt gaagggagac taatactctc 77943 ttttaagaga agtaagaatg aaatatccat ataaaataca ctgcattatt ctctttgttt 78003 caatggcaaa tagaatcaaa aggaataacc cactttattt aacggaatat ctgaaagtgt 78063 tccacttatt tatttctaat tttaactatg gaaagtactt gcattttttt ttaggaaaga 78123 aagccaagat tttataaagt aaaaatctgc tttgtgtgcc tttccaaatt agaagagaaa 78183 tgtatcatct taatacagca gattcagtta ttataaagac ctactccatc caaaaaattg 78243 agtgaaataa aaagaaattg acttacttgt taaagagaaa agattgccaa ggcttgcaga 78303 cttgtgaggt ggttaaataa caaactaaag actagcgaat atgagctatt ttgtttgacg 78363 tgccttccat ttaataaatg ctgtatcaat ctagctgttt ctctattttt aatcatacat 78423 tttgttgttg ctctaaattt aatcttacct tatacattgt ataatagatg tcccttaaat 78483 acatcaaatt taacgtgttc caaagaaaac tcataatctc ctcatctcca tccacctcac 78543 tcctcctgct gtgatcagtc tctccgtttt tgttcattgt ccatcatctt ctacagaaca 78603 gatgtgtcct aacccacttt cctaaacaca tttttgtata caaaataatt tccttttttt 78663 aatttcagaa ctctattctg acaaacattt ggcttcaacc tgtaattaaa aacttaacaa 78723 tacttaatag ttgcctcaaa gagcatcccc tctttgtcaa tgtgagacta tttacattaa 78783 tttacatgta attcagtttc atactcattc actggggtgt gaatattagt caaacgggca 78843 attaattaat acaatcttta tatattcact tattaaaatg caccacacaa ttcctaattt 78903 attgagagtt ctcactaaat ctatgggatg taaattttga aacagctgca gctgtttatg 78963 ccattgctct tgttgtccaa tagagccaag tggacattct tttttgttgt tgttctttcc 79023 ttgaatagag tcgaaattat gaatctaact ttctccgaca tgttgtctaa aaggatatca 79083 tcttacctta ctcagtgtga gccctaaaac taggaaatgt ttatcaatct ctgattgcag 79143 atcaagttta actatcaaat acagattaac ttttcagcaa aaatttgtta aatattcaga 79203 gatagaaatc ttgatgttgg atgacaaaga tcacttgtga agaactttat taagttttat 79263 ttggttgaaa aatctataat ttttagtgaa caactatcat ccattatgtt ccaagctttg 79323 tgacaactgt ttttatgtcc attaaaacag tcctataaaa taggtacaag tatctcaatc 79383 ttatacatgt caaaactaaa gcacagagat gctaaataac ttgactaaac aagatattga 79443 aggtgaagtc tgagatagat ttttaactcc gaagtgcata aactttacct ctatattatc 79503 tgtcttcaaa aagaatgatt ttaaagatta ggctttttta tttcagaaga aaatattttt 79563 acacaattct agattcttaa cagtaatttg aaggaatgaa tgtctgatga ttcaagaaaa 79623 gtgaggtaca ttttaaagga aaagtgacag acaaaaaatg gatttttgaa aaatgaataa 79683 agctgctttt ttttttttga tggtgtcttg ctctgttgct cacgctggag tgcaatggtg 79743 caatctcagc tcactgcaat ctccgcctct cggattctag tgattctcct gcctcggcat 79803 cccgagtagc tgggattaca ggcgcccacc accagactca gctaattttc tgtatttttt 79863 agtaaacatg gggttttacc atgttggcca ggctggtctc aaactcctga cctcaggtga 79923 tccacccacc tcggcttccc aaagtgctgg gattaccggc atgagccacc acgcatggcc 79983 aaagctggtt tttaaaaggg atcattgtac attattatca aatttcattt gaacgtcaaa 80043 aattctgagg caagaaggaa attgagccca ggagtttgag accagcctgg acaaaatggc 80103 aagaccccat ctttacaaaa acaaaaataa aataacacta gccaggcatg gtggtgcaca 80163 cctatagttg tagctacttg ggaagctgag gtggaaggat tacttgagta cagagaagag 80223 gttacaatga gggaggatcg tgccactgca ctctagcctg ggcaaaagag caagaccctg 80283 tctctaaaga ataacaaata aataaataaa gtctggacaa gcctaaaatc agtaatattt 80343 ggggaatatg caaatagtct ttgctttatt tactcaatta ttgaaactat attcaaaaat 80403 aggaagtaaa acatgattta atattattta gtaagttaaa catgttataa taatttggaa 80463 atccatgtat gttagttaaa tatacattac tataaaatgt aaatcagtgt ggtttgtagc 80523 agagacctgg attttttatc tttgtagtgt acctacacca tcacagaaag gtttgccatc 80583 agtctctaga ttaggtgcaa attcatttaa tgtgatccat cctattatct aaaaggtcat 80643 tctgttgttt tcagccttca tctaagacac tctcagatac tatttcagga atttatgaca 80703 gcaaaatgat ataaggtgac aaagtagaaa taggtgctat gctgctttac ctatattgag 80763 ttattttctt ctctccagga tcagatatta atgataaatt ctctaacatc aaaaaataaa 80823 acctaggtca tataaatttt acacaatcaa tgtcagtcac tcagcaacca ttgagaatct 80883 actatgttta gaatggaaca cctgacttat agaaaaaaag gtaaaagatt ggttttgtaa 80943 aatgacacat acaatttaag aaaaaatagg ctatctatat tagatagtta aaagaagatt 81003 ttaaaatacg ataagaagag aggggagaaa tggctagatt aatttgagga ttacctagtg 81063 ttaaaataag tccagattta aatcaagttt attaattctg aaaaagatca catcctaaag 81123 aaggcatcaa attgacccat aaatgtggat aaaacttctg taagataatg aaagccctag 81183 agagtaatgt tcaactccat tttctaattg gcaacaaatg tataatatgg gtacaccaga 81243 atatctaact caaaaagtgg ggaaaaaaac tcaaaaagta cgaaatgttg gcaaaaatgc 81303 agacagctag gacactcata ccagctggta agtgtaaaaa ctagtactgc accaagcact 81363 ttagaaaact taacggcagt tatgtagtaa tggtgatcat atgcatactc tatgatagca 81423 atttcactgt tagatatata actaacagaa atttgcacat atgtgtcaga agacgtacat 81483 aagaatgtta gtaacagccc tgtttacaat agccctgaat tagaatgaac caaaatttcc 81543 atcaattgta gagtatttca atgataatat aatcacacac tggaatgaaa atgatggaac 81603 tactactaaa catacaacct ggatcttaca aacataatca taagtgaaag aaattagaca 81663 caaaataaca cataaatgtt gattccacat agataaagtt aaaaacagat aacaattaat 81723 ctatggtgtt acaaatcagt atacggattt ccttttgttg gcagggggga tgttgttgga 81783 gaggaaatag gaagagagct tctggggtgc cggtcatatt gtacttctca gtctgaatag 81843 tagttacaag ggtatgtaca ctctgctgta atttgtccag tgatacatga tggtttgtac 81903 atttttatac atgtgtgata attcaataaa aatatctgaa aagctacaac agcagtggca 81963 acaacaaagc ccattaacca caagaaataa tcatgtaaat tgttttcttc aaataaatgt 82023 gttgtaaata acttctctca ctctttggca tatatttttg tcctcttttg atatacccta 82083 attttaggtt tgtttaattt ttcaaacatg tcctttatgt ttaatacatt tgaggaaatc 82143 tgcttaagaa atgcttatct actccaacat cttatcaatg ggaattttat ttttttaact 82203 gtcaaattta gatctataag taacctggaa tttatgtttg tatatgatgt gatgtagaaa 82263 tcaaattttt attttttcta tgtagatatc aatttattca gtatcatttg tagaaaagat 82323 acttctttga taatgcagta catggcactt ttgtcatatg tcaagagtcc ttatatacgt 82383 aggtgtggat ctcaactatt tttgtttgtt ttgtttttgt tttggatctc aatttttatt 82443 ctattccctt gatctacatt tatatccttg taccagtact atactgtttt gtttactgac 82503 actttgtatt aatatttgat agctaatgta aatccttcaa atttgttttt ccataatata 82563 atactgacta attttggccc attatatttt tatataaatt ttgaaatcag cttgccagtc 82623 tttaccaaag gaaagctagc attttaattt ggaatgcatt gaatccatat atcaatttta 82683 gagaaaactc acagccttac aatacttatt cttcgattcc atgagtaggg tatatccccc 82743 tatccattta ggttattttt catattcctc atattttaca gtgcagaaat catgtgtttc 82803 tcattatttt tttcctagat gttgaacatt tattattcta ttgtcaatag tatcatctat 82863 ttaaattgca ttttctagtt gtttttattt aatagaaaca taattgattt tgcatatata 82923 cattatattt tatatatcaa tttcatgtgc tcttatgtta catattgttt tatattcagc 82983 aagtgttact aaggtattta ttaagattag tagtttatct ggagattctt tcacacttaa 83043 taagtatgcc ctctgtggat aatgataggt tttatttaat cctttccaaa cttcattatt 83103 ttatttattt ttattgcttt attacccttg ctccagcaca atgctaaata gaaattacca 83163 taaaagactt tgtgcactta ctcctgatca ctgagggaaa gactatttat gtgaattagt 83223 atttgtagat attaactttt gagaatttag ctgtcaatcc caatatgaca acttggaggt 83283 gatgcatttt tttcttcctg ctttaagatt tttcctttcg tcactggttt ttcagcagtt 83343 ttatgataat ataagtgggt gtgattttct cttatattta tcctggttga aatttatagc 83403 acttcttata tctacaaata tataccttta attcgttttg aaaaattctt agataatgta 83463 tttgccttgc caatatcttt ttaaagattg cttttgtctc atgctacttc tatacacaca 83523 tattgagaat ccaatcacag gtataataga attttcacca tgtgttatgc acactcttct 83583 gcattttcct tttttcctct ctgttcttta gcttggatat tttctattag tttgtataat 83643 cctattagat ggttttatct aatctttctt tctgttaaat ctctttgttg tgtttccagt 83703 tcacatattt ttaagttcta taatttcctt ggactatttt tctatttttt atattcttta 83763 taatatatct actttcttga cattattaat tcaatcattt taaaatttct gaaatatttt 83823 atgaaaaatt gtagaaatta ttttatgttc tagataatat tatcttcttt cacagagaat 83883 ttgcttttgc tttggccagc agctagtgtt gggacagaaa accactatcc cgtcagtcac 83943 tggaggcttt ggaagctggg cttcattctt taggagagct tgtctacttc agatttatcc 84003 ctatcagagt tcataacttg gagttacagc tgaaagccag ggttgtttac ctacttgata 84063 ggccttgaac tccaattatc atcttatttt tggttaggta ctaaatttcc ggctcagcat 84123 ctcatattat cagctttgtt ctctgtttct cttctcctgt tcttagctag agtttgcaaa 84183 ttgccaaaaa ctttgagaag aaaagaggct aaatgccaga gcatctccct cttgcatttt 84243 ctccaggata ttggcctttg atgtcccttc tgccttagta gctttccaat gtcttaaaga 84303 aatgtgtaac acttctggtt gttttaggtg ggaagtttgt tctgcagtaa gcttatctgc 84363 cgttaccaga aatagaaact attttgtaat agtaaaacaa atgtatactt tcgtactaca 84423 atatttagta cttcagagaa caattggcac tttctggata ttctcaacca ggagtatgtg 84483 gttgaaactg cacagttttc tggagatgat ttaggttctt cccttcttac tctaattctg 84543 tcactggttg atcttatcca ctccacaagc tttaatcaca atttctattc tgatgaatcc 84603 caaatattta catgtaaaga aattatatcc cctggagtat agaaccataa atctaaatgc 84663 caactgggta ttgacactag gataactcac aggtgcttca aaattacata tacaaagttg 84723 aatttctcat cttctatcta ctcttacaaa gctacctcat tatcctttat cccctagctc 84783 agtgagcatc cccagctgtc aagcaatata cctgctaatc atcctcagtt cttcttactc 84843 tctcatcctc atatctaatc cctcactaag gcctgatatt tcaacctcgt tattattttt 84903 ggcattcacc tttttccatt ttttggttac caacttgctt tcttggaatt ttaaaactgt 84963 cagtattaat ctctctgctt gcaacataaa gacatatatt ttccacatat tccgcctaag 85023 taatctttga aaaatagtag taagatattg ccattctgtt gcttaaaatc tgtcagtaat 85083 tttgtaattt tccaattctc catagtctgt aggacaatat ccaaatgttt taactgaata 85143 cacacacaca gaaacacaca cacacgctca cacacatttt atgattcata ctttgagttt 85203 aattgaaaga tagaacatct ataagatgaa aacagttgta gtcagagatt ctggtatgca 85263 aagtaggaga gagagccaag aactagaggt ataactttga attataatat tgggttggtc 85323 ttctatagat gagacataaa gttgtgagag tcaataagaa caactaaaga aagataatga 85383 aagaacaaaa gacaagtgga ttaaagacag atatgcggtg aaagagaaaa gcatttctac 85443 agaaaagacc cccaaaataa gttcattgca ggtagtaaga tgaacagaag tcaaatgtct 85503 tggggaggat cggattggtt gcttgtgtat gttaattaat gcaaaagggt caaagagaag 85563 gactgacttt atggccctgt agaactctga gaacagggtc aaaatccaga tgcatttcta 85623 agacatcaca ctgggaacgg ggacttgtaa tgagttatct acaaagtgta aaaagatgtg 85683 ggtaaccaaa aggttgtcat ttcctccaaa acaaattttc ctggagtgaa actgtaacta 85743 ccaggtatag tcattaatag aactgcagac actaagacta tggaaccttc cgtcttccta 85803 accttctcct caggccagcc ttaaaggcct gtgaagatct attaataaca ctgctgtttt 85863 gttctctggc agctcttggt gccagaaggc ttggtgccaa tttgtggttg agcccctcct 85923 tgggagaaat catgccattc agagacagct gataagtcaa gcctattttc ccactttctt 85983 cactgtattt ttcctgtctg aagaacttgt ttatggattt gatttctgta gagataataa 86043 tcacaggatt cagtggtata gcattcctct atgcattttc tccctgcaca tttgtgtgtg 86103 tgaagatact ctttctaaat ccctttcaag acaaattatt aattgtgata tattaattat 86163 tctccactgt acctaacggt tatcaacact acagaggcac cattggttga caaaagtgag 86223 agcttttctc aacattaaca taatgagcaa gtggcaatga gaaaatattt gtccaattag 86283 agacttttat attttctttt cttgaggaaa taaaacccga aacacattta agatacattg 86343 ctgtttgtgc ataggcggta aatttttttt tttttttttt tttttgagac ggagtctcac 86403 tctgtcgccc aggctggagc acagtggcac gatctcggct cactgcaacc cccgcctccc 86463 gggttcaagc gattctcccg ccttagcctc cggagtagct gggattacag gcgcatacca 86523 ccatgcccag ctaatttttg tatttttgta gagatggggt ttcgccatgt tggccaggcc 86583 ggtcttgaac acctgaccgc gggtgatccc cccgcctcgt tctcccaaag tgccgggatt 86643 acaggtgtga gccaccgcgc ccggccagta aatagttttg aagttttatt taatcccagc 86703 actttgggag gccgaggcag ggggatcacg aggtcagaag atctagacca tcctggctaa 86763 caccgtgaaa ccccgtctct actaaaaata caaaaaaatt agccaggcgc ggtggcgggc 86823 gcctgtagtt ccagctactc aggaggctga ggcaggagaa tggcgtgaac ccgggaggcg 86883 gagcttgcag tgagccgaga tagtgccact gcagttcggc ctggacgaaa gagcgagact 86943 ccagctcaaa aaaaaaaaaa aaaaaaaaaa aaaaagagtt ttattcatat tcatattaga 87003 taaccatttg ggtggcacat ttcacaacac agatgcactt cttaagagtc ctccatccgt 87063 cagcgttgta aaaaaggaag tggcacgttt gcatgtagtt cttctgagac ggagatttag 87123 ggacaacttt gccaaggtgt gtaggtggag aatgggagat tgagacaggc atattggctc 87183 aggaagacaa gggagtaaaa ctagcaatag aaaggagggc caatgccgta acagtgtgat 87243 ggagtgaaaa caagaaaaag gaaaatgcct caggatttgg tggagagttt gttttacctt 87303 tttaagataa tactcctggt cagcttccca ggttcttaag tctggatact gtaatgattt 87363 tggatgactg cattccatga cctgtttcaa ggtaggtttt ttgaaaatag gagttaaata 87423 taggctttct tccctatgta ttcagttgcg tttttttctt tttcatttag aaatgttgtt 87483 ttatttcacg ttctcttatt tatatttaat tgagatggtg ttggccattt tatccttctt 87543 tttttttgtt ttcttttctt tttttatttt attattatta tactttaagt tttatagtac 87603 atgtgcacaa tgtgcaggtt agttacatat gtatacatgt gccatgctgg tgtgctgcac 87663 ccattaactc gtcatttagc attatgtata tctcccaatg ctatccctcc ccctcccccc 87723 accccacaac agtccccaga gtgtgatgtt ccccttcctg tgtccatgtg ttctcattgt 87783 tcaattccca cctatgagtg agaatatgcg gtgtttggtt ttttgttctt gcgatagttt 87843 actgacattt tatccttctt taaacattat tttctatcta gaaaatccaa cttcaaataa 87903 atatactcag ttctacatta taaaaagtat tacaatgaat ttaatgctta aaactcattc 87963 cggaagtgac gatggaagca ggttcaaatg ctttcactga cactttgtgg caaagtgtgg 88023 aactacagta tatttttcca agttgtttcc tgatatattt tttatgtaca taacaatcaa 88083 taaattgtta tgctatttat ttatgtactt atatgtaaat taaacaacca agaaatcgca 88143 aagtgtttta ttaagatgat atctaaactg aaatatcaca acttactaca aataatactt 88203 tgtttcaaaa ataatttgaa ttgcatataa aaatcacagt tgctgtgatt aacattgcat 88263 tgatatattg gaactaaggt ttttggaaaa attgtgtttt ctttcaatct tttaaaaaat 88323 accatattta taaaatgagt cattaagatt atccctaggc attttcattc tgtattgaag 88383 gtttttgagg gacatcatta ttagttcaaa gtgtgtttca cattttgtag tctgtcttac 88443 tatggcaact aatttttttt tttttttttt ttttttgtga gagggagcct cactctgtcg 88503 cccaggctgg agtgcagtgg tgaaatctcg gctcactgca gcctccacct cccgggttca 88563 agcgattctc ctgcctcagc ctcctgagta gctgggatta caggctccca ccaccaagcc 88623 cagctaattt ttgtattttt tagtagagac aggatttcac tatgttggcc agtctggtct 88683 cgaactcctg atctcagggg atccacccac ctcggcctcc caaagtgctg ggattacagg 88743 catgagccac cactcccagt cggcaactaa tttttaaaat tgtggtaaaa tatacataat 88803 atacaattca acaacttaat cagttttaag tgtatagttc aatgacatta agtatattca 88863 ccttatagtg caaccatcgt cactatccac ctccagaaca tttaaaattt tttaaaactg 88923 aaactcttca ctcatggaac aataatgcct ccttcccctc ttctcctagc ccctgggcaa 88983 aaaaaaaatc tactttctat ctgtctgata tgattgctct gagtacctca tataagtgga 89043 atcatgtaat cattgtccct ctctgttttt accttatttt aatataatca aaactaaata 89103 aataagcaaa ttcttaaaat aaaattgata tatttagtac agatcctttt gagacactca 89163 gtggtccact aattatgtac catatccaat cacatcacaa tatcataaat tttatagtca 89223 attattagtt ggcatttcaa ggcccaagta tatgtttaat aagagacaca atcttacata 89283 tgcagtttac atgtttttaa tctagtctta gcaccagcat atcaccttag tttacatttg 89343 tctaagtgca agtattggtt ttggaatgta attttgctca tatacaatct gtaagatact 89403 aaaacaaaag ctagtttatt ataagtgaaa taatggcaaa ggccatttta aaaatattgt 89463 attattttcc catttgaaaa tcagtttagt ctttagccca caaaataaca ggaaaataac 89523 ttaaatcata aaaactatat ctgaatatta tttaacatat tttataaaga tatccttctt 89583 tggatcatgg ctgcagatgt tttcatgcag cttgagccac tttccatgtc ttacggagaa 89643 tgtgcaggag ctatatatca tcagattctt tcagagaaag aaccggtaag acaaatgaca 89703 gtctgaaaga taaaggaaaa aaataattga tatcttcttg gcacctctgc atttcaaaaa 89763 tactatttca ataaagtcca tgttagaggt ggaattcaag aattcactga atctgcattc 89823 ttgccttctg ctatcctctt ttgccctcat ttgctcaatt attcctcact cctggttaat 89883 gaaggcaggc ttttaaatac agactaacca taaattgact ttaatattgg tgtttaatgg 89943 ttattcacag aactgattta aaatgtggta tcaagttcag gtcctgggat ttaccaaagt 90003 tcatcagagg acacagtaca tggcgaattg agaaccatag cctactttat gtctaagaga 90063 atattgacaa acagctaagt tctctgtgag ctctcagatt tcactcaaaa gaaatgaaga 90123 aagtaaattc tctgtttaga ctttgtgcct tttttctcct tttaaagaat ttgctcatcg 90183 gaaaatatac cataccaatg gcagcaacat actataagtt tatgagcaaa tcaattccat 90243 ccatagttac tgcagaatgt attataggca gtatttttgt tgggagaaaa gcagcagaaa 90303 cttagcaaag taagggaaag agaaaaagca gcttataatg ataaagagcc tttgtgcccg 90363 tagagagata agaaaaaata caaaagaaat ccataatgat ccacaataat tttagaatgc 90423 aatttatggc catgaagggt acaacatgtg attgggtatc aaagaagaaa gaagtcatgt 90483 taatttaggc taattaaaag atattttgtg aagcagaaag ttttttattt tgttggttga 90543 ccagttgatt ttggacagtt ttggatacta tttaattggt taaaaagcta ttgaaatgga 90603 gtatcaacca tttccagaca gaggaatggc atgagtgatg gtctgggcac ggaatatgtt 90663 tgacacacag tgaaatatca gattcactct gatgctctgt gtattttacg ggaaacatta 90723 taagggataa agggcaaaaa ttcaacagaa acccagttac tattggccat ctgagaattt 90783 tgtactgtcc aggagaaaag agagctctca ttgaaatgga agagttaata caacaagaca 90843 ttgtgcttgt ctgtactcct atatatttta tccattaaag gaattaatgg attttatcca 90903 ttttatgaca tttattattt tatgacactt atccattaat gacattaatg gataaaacat 90963 ataggagtac agacaggcac aacgcatggg gaaactatta ggaggtcact gcaatactct 91023 agctaatggt tacaacaatc tgacattggg tatttgcaat aggaatagaa agaatataat 91083 agaggaaaga gatattttgg agatttcaag cataattaat gggagaaaat ggaagcttat 91143 acttcagaga agcacaaagt ccagtgataa gtttaagttg tataaattta gtgtgctctc 91203 aggagaaggt gatgtttact ttgtactttt acaaccttgc acgggtgagt gggttactga 91263 ataaacaaat aaatgtttgt gtaacacaaa tttagagaat gtgcagttgt agatatatat 91323 gtagttctga atagtccatt taaagacaga tactaggttt tcttccaggg tttctagagt 91383 ttcgggtctt acatttaagt ctttaatcca tcttcagttg ctatttgtat atggtgagag 91443 atatgggttt agttttgttc ttccgcatat ggctaatcca attttcccag caccatttat 91503 tgagtaaggc gtccttcccc agtgtctctt tttgttgagt ttgttgaaga taaattgcct 91563 gtaggtatgt ggttttattt ctgggttttc tattatgttc tattgatcta tatgtctatt 91623 tttatactat taatagtatc atgctgtttg ggttactata ggcttatagc ataatttgaa 91683 gtcagttaat acgataccca cagctttgtt cattttgctt aagattcatt tgactatttg 91743 ggcatagcca cagtctttaa atatttgaat ggacataatg tgaaaaccac acttaagata 91803 tgtttaaacg gcacagtaat attatctaac acaaactcaa aattcaaatg tatccagttg 91863 tcccaatagc tttctttata aatatctttt tttcttttta tttcttctta ggattgaaag 91923 gtaaatatcc tagcatctac acaagggaac cgatgtgtgt gtgtatatat atatatatgt 91983 atatatatat acacacacac acacatagga atacatacat gtatatatac cagtatacac 92043 atagaataca taggaagatt ttttatatat atatatatat atatatatat atatatatat 92103 atatatatat atatatcttc cccaaaagtg tgccttggct tttaaaaaag cttacaagat 92163 ctcaaactgt cttaatagac tgacagtaac caaatcaatc atccttctca ttgttgctct 92223 gagtagattg cacctggaga aatgattgca ggtatggata gctcacttag agctattact 92283 gataatctga agtgtgttca gaataaaata accagggtga tggggaatga aaagcccata 92343 agtttcacat gatggattct gattatcttt aggctggaga agcataggct agggaagtgg 92403 gcatagctgt tgttgttaaa tacttgaatg aatgcctttt tgatttgaat tgtgtttctc 92463 caaaaatata tgattaagtc ctaatgatca ttactcagaa tgtgacctta tttggaaatg 92523 gggtcattgc agatgtaatt tgatatggta aagtcatatt gcagtagggt gggcctttaa 92583 tccaatatga ctgggatcct tatgagatga tggccatgtg aagatagaaa cacagtagaa 92643 tgtcatgcac tgacaaaggc agaaattgga gttatactgc acaagctaaa gagcaccaaa 92703 gattgcctga aaaccacaag aaaataggaa gagactaaga agaactttac tacagctttc 92763 agagacagga cagccctgct gacaccttga tttgagagtt ctagctccag aactgtgaga 92823 caataagttt gtattgtttt aagacaccag gcttatggta cttttttaca gcagccttag 92883 aaaacaaata caatgtacat atataggtaa agcttattca ttcagttcca agaaataatt 92943 aggatcttgt aagcagaaac gaagggaaaa cagaacatga acaagaactt gctagtaatt 93003 aaagccactg caaaatgaac tcaagggctc cagcaggttt taaattacct ggtattataa 93063 atgttcaagc aggatgaatc agagatggtg cagaggtgat tattcatgca tcagatggaa 93123 ggttagactg aataatctcc aagtgaaaaa attatatgat cctatcttaa agccctgtca 93183 aatagaggtt ggtagcttcc ttttcatttt ctgcttcaat caagaggata tatggatgat 93243 atagcttggt ggataacact taaattgaag acctagtact tagttttact tttacttact 93303 ctagtactta atttttctta ggtaggcccc ttaacttctc tctccttatt ttcccacctg 93363 ttaaacagag atattaatgc tattcacttc ctagtgttat tatgatgaaa ctagttaata 93423 atttaaaaaa tgcttagaac aaggcacagc acatagtaat gactaaagaa agaagtgctt 93483 ttgaacatat atttgctcta ctattgtcta gattgtctag atataatgca ttaagtcttc 93543 ccaccagtgc cattgctcgt gtccaaaata cagagttaaa agattagaaa taattgcatg 93603 ttttctaaga gtcctgcgca ttttcctaga tccaatattg tactatttgg acaatttatt 93663 gaccaagtac cagaaatata atatttttgc caattttctc ataacaaact gtgataatgt 93723 gtatgtcaac tgctagggtg ggtttgtgtg tgtgtgaata tgtgtgtgtg tgtgtttcaa 93783 gtgtttatag aaaataaatc actcaatggc ataattttca aataataaag actacagtta 93843 ccctgattaa ggttcacctg agttttggat attaccacgt gagagttaga ggacaatgtg 93903 aagttttcaa aattaaatcc tctgaaatcc aggtatcttg ttaaattgac atctgttggt 93963 agctgacagc caatttcagc ttcaggaact agtaagaaca ttttccagct tatgaaacta 94023 ttaataaatg ttacataatt gtccaaagaa atcctcattc agtgattcaa atttaacaaa 94083 attaggtttt atttattcgc tatgtaaaga tactaatccc tgcattattt gggtgcatgg 94143 gtgacagctc tgacaggttt gtgatgcccc agacaaattc agtaactttc agtgaagcaa 94203 acccatgaat agatgtgatg gcagcgtgta cacctatata attccagagc tagtgattat 94263 gtaactttta tatacgtcag accgaaggaa gacagagaat ggaggaactg ggtgttcttt 94323 cagtaaagag caactgaatg agacagtaca tcttttgaac tggggatata ctacaaggca 94383 atgagggagg ctggctatga aagtattgaa aaatatgttt gattgctggg tgatgtttag 94443 aggccctaag gtaatagaaa ggagacaaaa ttgagagtct ggaacttata tgtactttat 94503 tacagtactc tcattttcac caaagaaggc aacccatgtg gtgaaaagac cacaagcatt 94563 ggagctaaag ccaagttata gctgtagttt tatattttgt gagcccatat gtcctcagac 94623 aagtttcgtg agttaatttc ctttgtctca gcttcctctt ttataaaatg tgggtgatat 94683 cattgtccct taagattgtt gtcagcatta aacaacataa gtatatgaac catctagctc 94743 ggtatttggc aatggtagga gctgaataat tgttagctct taccttaaaa aattatttgt 94803 taaaagttcc aaatgcagcg ttcaggagaa gatatgggtc aaggtcatgg atgaggcaaa 94863 cactacaatt caataaaaat tgttagttct taatttatct taactcagca accgtttctt 94923 gagactctac tacatattga gtactgaggg aatagaaaga tgaatcaaag accattttaa 94983 aacatctggc atttgcaatt caaaatcaag taaaaataaa tacagcctta tgatttattg 95043 agaaatgtca tgcaaggtaa atgaactgat tttaagcatg tacttagcat tcacacagat 95103 tgacagattc agtgaaaaca cggcacagcc ttcaattatt tttcttttta aatacatatt 95163 tgtggacttt atagaaatac tgacagtgtt tcctcaccaa tacctatttt ctttgttgag 95223 tgactattcc tttttctttt caaattag tt tgt gtg gca gtg tgg aag aac cac 95277 Val Cys Val Ala Val Trp Lys Asn His 75 80 cac atg agg acg gta acc aac tac ttc ata gtc aat ctt tct ctg gct 95325 His Met Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ser Leu Ala 85 90 95 gat gtg ctc gtg acc atc acc tgc ctt cca gcc aca ctg gtc gtg gat 95373 Asp Val Leu Val Thr Ile Thr Cys Leu Pro Ala Thr Leu Val Val Asp 100 105 110 115 atc act gag acc tgg ttt ttt gga cag tcc ctt tgc aaa gtg att cct 95421 Ile Thr Glu Thr Trp Phe Phe Gly Gln Ser Leu Cys Lys Val Ile Pro 120 125 130 tat cta cag gtaattgttt ttaatgcttt tttgaagcta ctaaaaagaa 95470 Tyr Leu Gln tgttcagcca tagcgatggc ccttatggta aattaactag tgagttgaga aatatatttg 95530 cctaaggcat tgacaaactg aaggaaaata atacttgaga atttctggag aaataagtta 95590 agttctgggt aaaaattaag caatgaactg ccaaatcatc attagatgct gcacaaacat 95650 ttttgcacaa cttttttgat tactaatttg attccaaaag tttgattttg cacaaacttt 95710 ttttattcca aatttgatcc caaaagtttg attttgcgca aacttttttg attcctaatt 95770 tccccattgt taaataagaa acttgaacca attaatgatt taaccaatta atgatctccc 95830 caaaccaatt attgatcttt ctcttgaacc aattaatgat ctgccagtcc aagtcattga 95890 gcatatttgt ttttacaagt gattttattt tatactgaag aattaagacc tacttggtca 95950 aatcagtgcc atgaacaggt tttagtgtag attctaattc aaactaccgg atttggaatc 96010 tccgttctgc cattcaccaa ttgtatgcta tcaagccaaa tagttgtaat tcacttattt 96070 aaaagaataa tttaaatgag atctacctca tatggttgct gtgaccattt acttacataa 96130 ttcatataaa taagttggca cagtgattac cctctggaag agatgatctt ataaaaacag 96190 tatattctca ataaacatca attatcagca tcagaatcat cattactagg tgtttttctt 96250 tccttaagag tgaaaacagc ttctttttct atttaattgc catttcagta attaagaatg 96310 aatactttca gagattagtg ttctgattgt tattatagct ctaaaatttt tgaaacaaaa 96370 gattcatcag ataatgttca cattcactca tccatcctaa aagatggatt tcccttagga 96430 attggacagc aaatgaaatg gtgaccactc tctgcttgtc ttcccatagc tttcctgcac 96490 cctcagtttt tacgccatgc agtctcccag atggtgccta taatatttta agaaaacaga 96550 aaataagctc ccagtaacaa aaaattaggg aggggtcaca aatagcctat tactagacat 96610 tatgccgatt aggcttttgg aatgaaatgt tgcaaagaga tatttagttc aatagttcct 96670 caattacctc ttataaaaag aagtgaaaaa tttttaaggt taaacattgt ttatagaata 96730 gtaagtggaa aatactatag aagttataag ctccatgcat atattatgtt taattataaa 96790 gctagtttgg atcagcctgc tgaaaatcat gaatggatta caaaacgaac agtagcacat 96850 ttttttgtgt gtgaggaaaa actacatggg acaatagaga aaaatattct catagaggaa 96910 aagttagtaa gaaatgaatg gctctggtgg tgtttgcata gaggcactag gaaagtaata 96970 catttcagat aattctaata tttcattatc tctgtggtac ttccagaaag ccttttacct 97030 ctcttggttt caataactac ccaggagaat attttgagga ttctcttaag ttttgggatg 97090 gctgcagttg cccagaatct tcaactgact ggtaacattt catgttctct ctgtgaaaca 97150 gaagattccc tggtgggaag tgaagtgata agggcaggtg cagtcatgtg ctaatgcaca 97210 gcgatagctt tctgcagagc aggcatctca gagtttcctg tgagtatttg cattagagga 97270 cagaatggaa gcagtgtaac cagtgagtga tgcagagcat gggtatctct tataatcact 97330 tacagtcctc tttcacacag cagaactatt taacaagtcc tacagttcaa ggaatatcct 97390 catctctgga aggattctgt ctgcctctct gcacacagtg tccaatctaa tcaattcctt 97450 agctgctcct cttctccata gagcaaggga aaaaactact gggtaaccac atgatgcaaa 97510 agactagatc catttgttac cccatctaac attacttctt gatggaaagg tgtaaatgca 97570 ccaagagatt ggtgcacagg taaaactagt atctccaaat tcttcatatt tattgcctca 97630 tttttcatag aatgttccca aatgcaatga acagtgccaa tgggcaataa acatataatt 97690 taaatttgag cagattttct ccctagttgt gacattctgt aactaatgac ttatatccct 97750 gatatgatat ttatgtctta ctgaatattt aaaaacatgt tacatcatgc ccagccacat 97810 tttaaagtta tttggttgca ttttagatta cttggacgtt tattaatttg ctataattta 97870 tatgttcttt ttcttctaaa tacaatacag cctttagatt tatgagtgat atgctgtaac 97930 gcattggcaa atgcacaaaa atctcaaaag tctcacaaat gttataaagc ttagctgaat 97990 aattaaaatg actcttttgt atctttaata attgcataac tccaagacca ttaacatgta 98050 ttcagctatt tgctgaacaa ttatcatgta tttcacttct cttccaacaa tgacaagagc 98110 attggttact ttttcagagt gatttttttt aactgcagaa gacgccctac acagaaaatg 98170 ccagaaaaaa aagaagccaa gtgagatgtg ggaggtgggc agtgggtggt caaacaagct 98230 ccctctcttt cagtcatact ttgaaacctt tctacctatt agtgcttatc atccaaatct 98290 gtgatttggc aaaattttca tttctcctta tagtgaatct ttaagatacc tttgccgtat 98350 ctatttgcta gtataaaaca gtggacttct ctactaaagg aaatccccaa acattatcct 98410 gtgcgaaggg tgcccatagt ataggtcaaa gaccaagtac ctgaaggcag aagaaagttc 98470 ccattatctc actccacttc attctcaaca ttcataatcc acactagatt catttctcaa 98530 atgacttact attcaacaaa cttgagctaa tatcagaatc caaatgaaaa agacacccag 98590 aagtgcactc ttagaagtta aaagcaacaa caaaactttc acttataatt acttatgata 98650 aaatgcaatt ttacatcacc tccaagaaaa tcttatacat tgcacataat tgtatattaa 98710 tgtgttaatt gcacaagcaa atatagtagg tcaaacaatg aatattagct cactgattgt 98770 caagggttca ttcaatggat tggttcattc tactgttaga tacatcacac tagcatattc 98830 ctcccttttc tgtgtgatga agggcagtgc tccctgggtc actattggca ctggatgtca 98890 gtcttccaag tgaactgata tgaattgatt attatgacct aatggcatta ggaaacacta 98950 gaaatgacat tgatatttga accatgctac atctatccca tttatccatg ttgattaaat 99010 taatggatta taaattacta aggcttgatg aacactttgt acttctaatt gctagagagg 99070 attgatatat ctctagccca gaagctatga aaaggcgact gtgcgaatct atacaaccat 99130 agttctattc ccaggttagc aatggtattg aggggcccta ggtgcttaac ttatttgcag 99190 agaaggaatg gaggttgtag agaataaggt gatactggtt tgagaaagag agttgaaggt 99250 accctcaggt agcactaaga aatttctagg agtcactaat caacttaagc ccattctcat 99310 agagtccagc cccttaaaat tacacttaaa atgaaattag cctccaataa tttagcaaag 99370 gttaggcttt cacttgtaat ttctatgaat attcttctct gaaaagcaat ctgttccaat 99430 taaaatatag aacttcagac tcaagaatga aagataaaac taatagtatc atcatcatta 99490 ttattattat aatcataaga aatagtaaac acacagcact tatatgccag ccctggaata 99550 gacattttca tctcaactaa ctgtccatac aattccatgg ttaggtacta ttaatcatcc 99610 acattttaca gatgagaaaa ctgaggaatg gagaggttaa ataatctcct taagatcact 99670 ccatatgtca gatgggattc atgcccagaa aacctggttg cagactcgat tccagctata 99730 ctcttctgcc tctcccatag agaaacaaaa gaatcatact tgataagaat cttatcctgt 99790 tgatttactt catttagcac acacacacac acacacacac acacgcaaca cacaacacac 99850 aacacacaca ttaggcctaa agctgtaaag tgagtgactc aatagtgtgc agctagctga 99910 tcagagagag agaacagata gttcatcctg acagcccaga gactttctgc actgttgcac 99970 tggatcttag atctctttca ctcatttgta cctataatca acatatcaac aagaaaggtc 100030 ctcatgtaaa agacagagat aactaccctt tccacatatt atgagatcaa tataaccagg 100090 acagaaaaat agaagaagat gactggacta tatctactgc cttcaattaa ggctcaccac 100150 tattaatgga ttaacaaata tttgttttaa agacacatgc aagtatacgt tcactgcagc 100210 actattcaca ataacaaaaa cgtggaatca acctaaatgc ccatcaatga tagactggat 100270 aaagataatg tggtacatat acaccatgga atactatgca accataaaaa agaatgagat 100330 catgtccttt gcagcaacat gaaaggtgct ggaggccatt atccttagca aacaaatgca 100390 ggaacagaaa agcaaatact acatgttctc atttataaat gggagctaaa tgatgagaac 100450 acatggacac ataaagggga acaacacgca ctggggcctt tcagagggta gagggtggga 100510 gaagggagag gatcaggaaa aataaccagt ggatacttgg attaatacct gggtgatgaa 100570 ataatctgta cagcaaacac ccatgacaga catttatcta tataacaaac ctgctcatgt 100630 acccctgaaa ttaaaataga agttaaaaac aaaatatttc ttaaatgcat aatggatatc 100690 aaatgttgta tcagatattg gggacacagt tgtgaaaaaa acagaagcag tccctcctac 100750 cacagagctt tgttccaata gagaaaacag atgataaata agcaaattaa gcaaataatt 100810 tactacatta tacatgctga aagaaaaata aataacaatc tgtaaaaaaa aatgtaaaag 100870 aaatcagaag tctttttaaa gggagagggg attctgagag tgatatcaga atcaatattt 100930 catccagtat aagagagcac attgaacata attacattaa ctaataatgt ggatatatga 100990 atttttaaaa ttttttgttg ttgttatttc cttaaagtgt caagttaaag aatgatttgt 101050 ggcattgtta attatataca aattttgact gggtgaactt acctagtttt tggaatcaca 101110 ttgactaggc tagcagtgag caaactgtca taaggagatt cgcatacaaa attctctttt 101170 aatatgactc gtaactttcc ttgggtgcta catgttgaaa atgcactgat gtacaaatag 101230 cccttattat ttgaaaatat gaaataagct acccataatt taaaaatgtt aattaaatat 101290 aatttcaatc aaatttctat gtggtaattt agaagaaaga catattattc tttataattg 101350 aggcttttcc agtttggact aaacatatgt gttttttttt ttctatatga gggtatgatt 101410 tcttccaatc aatggaaaaa ttacaggaca aaataattac agtaattatt taaagaatgc 101470 catattataa attaagacat ttggagtaaa aaaagattgc aaagttttca tcataccttt 101530 tcatgtttaa caataaattt acatttaaaa gtatatttct aatatttcat ttttgtgata 101590 taatttcttt ttaaatagaa agcacttgca tggattgttt atttttggca gctttgaatt 101650 tgcttatatg ttgtgactac ctttctcata tagtaaatat attaagagta attcttttaa 101710 cagctggtgc ttctctatta ctatgatctt tcttttctct ag acc gtg tcg gtg 101764 Thr Val Ser Val 135 tct gtg tct gtc ctc aca ctg agc tgt atc gcc ttg gat cgg tgg tat 101812 Ser Val Ser Val Leu Thr Leu Ser Cys Ile Ala Leu Asp Arg Trp Tyr 140 145 150 gca atc tgt cac cct ttg atg ttt aag agc aca gca aag cgg gcc cgt 101860 Ala Ile Cys His Pro Leu Met Phe Lys Ser Thr Ala Lys Arg Ala Arg 155 160 165 170 aac agc att gtc atc atc tgg att gtc tcc tgc att ata atg att cct 101908 Asn Ser Ile Val Ile Ile Trp Ile Val Ser Cys Ile Ile Met Ile Pro 175 180 185 cag gcc atc gtc atg gag tgc agc acc gtg ttc cca ggc tta gcc aat 101956 Gln Ala Ile Val Met Glu Cys Ser Thr Val Phe Pro Gly Leu Ala Asn 190 195 200 aaa acc acc ctc ttt acg gtg tgt gat gag cgc tgg ggt g gtaagtacct 102006 Lys Thr Thr Leu Phe Thr Val Cys Asp Glu Arg Trp Gly 205 210 215 tatggcccat caactgacat ttatattaca gcagcaaatt gaaaattgga ttagcatagc 102066 cattgtaaag ctgggcttat atattttatt gacatttgtg aatacagttt tgcaagagca 102126 tgaaaaccaa cttgaatttc aaaacaattt cacagaataa ctctacctat ctgaatcctt 102186 tggaaatgtt atctattatt ttctcatttt catatctttt ggataggaaa tgaaaggaga 102246 ttattctaca attcagattt gattatttta gtttttctta aactctttaa acaaaaagca 102306 atatggaata caaatccgat tatgtattct ggaatgatcc acgatttata agatggttca 102366 acactgtgtt gtctagtgtc agggtcccta atgggcttca aatacaactg aattttttca 102426 ttttaagacc atgtcctgga tcacatggtc ctgggaacat ggccagagtc agcatgtggt 102486 tctctaagtc aaataatcca aatttgtttt ctctattcat aatacattat tgctactcgc 102546 ataattatta tccagtttaa gaattatatt aattatgaat caatctggtt tcccatctga 102606 caagtatgat gtgaaattta agcaatcagg tttgaaggct ttatgtttct ttggttagaa 102666 attcttagag tcagtctgag gtttttgtgt aacagtgaga atactgctat caacacctgg 102726 tgctagcaca aatctgggca caggaaagaa tgacagaaaa taaaataacc ctgcatttca 102786 gcatagcatg cactgattcc aatatatcat atgaaatata tatttaaaaa aaaaccaatc 102846 tgacctcttc taggtaagta tactaaaaat ggctgatatt tagagaattc atatgttaac 102906 attgtttttt attagaaaga tgtatcaaaa caagcagtgc acaccaggga ctgattaagg 102966 ataatattct taaatattgt aatctttgaa tttctgttat ttcctacctt ggtgtttgta 103026 ctagaacacc gaaaggaaaa aaagccaatc actgatatat taggcatata ctacaggata 103086 tatctacagc aagataatat ttaagagagg ctgggattat ttcatatatt gttgcaagac 103146 ctataataac taaaatttta taatttgctt tatctattac cccaaatatc aaatatctgt 103206 cttttattgg gatttacttt tcctttttaa cattccaact tttttttgct gtatttttct 103266 ctgtatcatt ttcagttttt tccaattttc caaattaata gtgcagacaa aaaaaaaatc 103326 aatggaaatt tccaaaatgg taggaatatt tatgaagtgt cttatgtccc attcatttaa 103386 tgctcaaaca ccaccttgag aacttagtat atgtcaggca ttgtgcccac ctggagagaa 103446 acagactctg cttacgggag cacactctat ataataaggc tcaaaggcca ataaacaaat 103506 ttttataggg taatcagtat tttaatatat ttatatacaa aatgctgaga acacaaatga 103566 gagaacaaac tcagttctgg ccatttgaac aaaagtttac agaggaactg ctaacattcc 103626 agcagaacat taaagataag caaaaattct ccagactgag aagagggaaa aggatgtcca 103686 gaaagcaaga aaatccacat catggatact acattacaaa gcagaaagag tgaatcagca 103746 cttgtagttt ctggaacata ggggcaggta gtgtaaataa ttgaattttg aaacaagatg 103806 ggttggggac tgactgtgac atgtctctta tacgatcctt ttacactggt ttatatttag 103866 aaagcctaaa aaggtctttc tcagaatcct gtattaaact cgagactaaa tttaacccta 103926 gaaagattat attatttttt caagattatg aagcaaatag gtacatttaa atctaaagct 103986 tccaacttgt aagttgggat tccttaagtt ttatagggat tgctattaga taaaatataa 104046 aaatattttt caatatgtgt cagcagtatt ttctctaata ttccggcaat tagtttcact 104106 tatatgttta tgggttgctt ttataagctt ttcttttttt aatgtttccc tgaataatca 104166 agtaacagta acctccatta acaaaaagat tgcaaagtca tggattcctg ttcagttatt 104226 atgattatgt aaatagacgt atgattttta aattacctct gagtggtaaa tataaataca 104286 taaagctcat ttctactctg atattttatt acataactct agcatggaca ttttcattaa 104346 aaaaaggaaa caattgttga atatgtaaaa acctaaactt agccttcaga agtcatttaa 104406 gaaaactatt tgaaggtgat tttataatag cctataatta aatgcttgta aagactaaaa 104466 ttaagtatta ttggactgaa ttgattagct acaaaatcca acttagtaaa agctatacag 104526 tcatttaaat attaaatgaa attgctaaga atatttttaa gaaaaaataa ttcaaggcag 104586 atttttatct ttcttattag atatttatta tgatgatttc tacatagcat gtaaaatcat 104646 tgttcatgta aactatttat aagtccatgt tcgacttata atgttaaacc tttgtatatg 104706 tgtgattgtc acaacttttt aaaaaaccat aggaaagtat attttacagt gtcatctctc 104766 taaattcaaa tatttttaaa ggccaactgt catttagcct gatttttaaa actattgtaa 104826 aatatcttct atttgagatt aattcataat ctgtgtttct tatctttatt ctaagttaaa 104886 tcaataatgt agttataaaa gtagagagta gaatcataat tatcctacaa ccaatgtggc 104946 agtggaaaaa aatttggaaa agcaatttgg tcagttgata catatctatc aaataacttt 105006 tggaaaagtt ctgtaaatgc tgttttactc atggtgcaaa ataactgaga actctgtcta 105066 actaaaaaat ttaccagcaa tatgtaatta tatatggata aatgatttct aaaactaatt 105126 atattcatta ttgcctatta cttcttcata aaaagaacca taagccatga tttctggcag 105186 acacacacaa cactcaagaa catataaata atgtaaatac ttattttaat aacctttaaa 105246 atatacattt gtatgtgttc actgtttgct tcagtcacat catttcatac ttctaaaatt 105306 attaaattaa cccacaattt cttgcttgct tggtttgtaa atgcataatt ctacaggaaa 105366 gatcctacag aaagaaattc tttgctgggt gtggtggctc aagcctgtaa tcccagcact 105426 ttgggaggcc gagatgggcg gatcatgagg tcaggagttg gagaccagcc tggccaacat 105486 ggtgaaaccc cgtctctact gaaaacacaa aaattagctg ggcatggtgg tgggcgcctg 105546 taattccagc tactcgggaa gctgaggcag gacaatcgct tgaaaccgaa aggcggaggt 105606 tgcagtgagc cgagatcatg gcactgcact ccagcctggg caaaagagca agacaccatc 105666 ttcaaaaaga gagaaaataa ctctttttgt acactcaatc aaagttatat tttcttcact 105726 attcattcat ccagtgttta attagcatgt acccttggtc aattgttctg gacactggag 105786 attagtagca tctctctttt tgaatattac tgacaaattg ttctttggta ggctaaaaaa 105846 aaaaaatgga accattttta cagtcaaagt aattatggca tctggcctat tatgaggttt 105906 gaaagcatat aaatatgtgt ataagtctat taatgggaag atttattaaa catatttatt 105966 agggagaaga tagtaaaaca tattaaagat tcaggtaaac ttaatgaacc cctaaacttt 106026 gaaaagacat tccatgttga atattgggaa attatattta atttacttgt tcattcaatt 106086 cctgataagt gtaccatgaa agaggaatgt ttctagtttc tagataatta agataacatg 106146 ctggctgaat aatgaacctt aagtcatctg agagaaatta agttttgcct gtcaaatata 106206 caatataact ctttaatctc tgatttcaaa gactaaagat ccacatttgt tccttattag 106266 ttagtttcat atatatatat ataaaattta tttagattgt gcttattcat cagttgagta 106326 aaaacagtaa tttttaatga ttatcaatat ttaaaacttt tttaaattaa agtaatgctt 106386 atgtgaaaca aattttgtgt agttatattc taggttatat acaaatgtct taaatacatt 106446 gaagacattg cttatgaagt acagaaagac ttcaaagata ttttcatcac acataattta 106506 aaatttcaat ggcatatctg agtttttaat cagcttagac tatcatgttt ccctagttat 106566 ctattataat ctccttattc aaacaatcta tcctaccctg gaaggataat tttgcttgat 106626 cttttttcca tatcagtgtt cattataata atttgcattt agcagtcaat tacatatttt 106686 ttctaattat tcataaatat accaaccaca taggagcttt tgctaccatc tattcaaaac 106746 gccaaactgt tatcacagtg atgctatcca tagctgcagt ggaaaaaatt tacctctcaa 106806 atctactttc ctctatccac tcaattggtc ttatgcagac aacagggctt cgcaggtatg 106866 taagcttcaa agttatatag attttgtcat gaggaaagct catgtgacac ctcttcaaaa 106926 caaataaaag ttcaaagcct cttaggtgcc tgggaagtgc tgagatcact ttcagattcc 106986 tttgaaattg gcccgccata tgctgtgtag gctgtggcac ttcaaaggga aagactgtta 107046 tttctcaagt cagaatgctt gaatgttatc actttttatg taactggcct gctttacagg 107106 atcaacttga aagaaagttg gaaactgatg aggtaggtga gtgctacctg ggccagagag 107166 tagctaaaaa tgacacctca aattggtctc ttagacctgc caacacatgc atcctactga 107226 ccctgctgaa gactgcagcg gataaagaca tctaaaccaa aagagaagat gggtttagaa 107286 gcatgaatat ggagaaaatt agactcaaac tcaactgcat ctgaaagaca gcctatggaa 107346 ataagattgt ggaggatatt aaactcataa atatgttaaa atatatccag caagaatcaa 107406 atgcatgatt gctcaataaa tattatctat tattatgaca atcatcatgc ttattattga 107466 ttaatcctga ctgtaaactg ctcttatcac aaatctgatc acataaccaa gctttcatgc 107526 ttctacatcc cctttatgaa gtaatgaaaa gaataaaata catagaggta atagcattat 107586 tcctcaacaa tactatggga taaaccccct tgtcaataga aaagtcaaaa caaagtatgt 107646 aaattttaga agaaaaacaa aacagctctg ttgtgttagc attcaattag aattataatg 107706 agttaattac atttaatatc tatggaatct atgcaagata tattgcttcc tcttttacat 107766 tgcagtaaaa gtaggtagac cattgtgata tattcgaata caagtacaaa aatatcttct 107826 aaaatctaca gggaactcaa acaaatcagg aagaaaaaat gcaaacaatc ttatcaaaag 107886 ttggctaaga acatgaatag acaattctca aaagaaggta tacaaatagc caacaagcat 107946 atgaaaaaat gttcagtatc actaagaatc agggaaatgc aaatcaaaac cacaatgcaa 108006 taccactttt ttttttattt tttattttat tttttgatgg agcctcgcac tgtcgcccag 108066 gctggagtgc agtggcatga tctcagctct ctgcgacctc cacctcccaa gttcaaacga 108126 tactcctgcc ttggtctccc aaagtactgg gattacagac gtgagcctgt aattggtgtc 108186 tggccaatac caccttactc ttacaaggat ggccataatc aaaaagccaa aaaattaagg 108246 acattggaat gaatgtggtg gagagggaac acttttacac tgctggtggg aatgtaagct 108306 agtacgacaa ctatggaaaa cagtgtggag attccttaaa gaactaaaag tagatctact 108366 atttgatcca tcaatctccc tactctggta gctacccaga ggaaaataag ccattatact 108426 aaaaagatac ctgcacatgc atgtttacag cagcacaatt cgcaaatgga aaaatataga 108486 accagcccaa atgcccatca atcaatgagg gaataaaaat atgtggtatg tatatagcat 108546 agaatactac ttagccataa aaaggaacga aataatggca ttcccagcaa cctggaggga 108606 tttggagacc attattctaa gtgaagtaat tcaggaatgg aaaaccaaac aacatatgtt 108666 ctcactcata agtgggagga tgcaaaggca taagaatgat aaaatggact tcaggtactc 108726 aggggaaagt gagggagagg gggtgaagga taaaagacca cagattgggt aaagtgtaca 108786 ctgcatgggt gatagatgca ccaaaatctc agaaatcacc actgaagatt catgtaacca 108846 aacaccaact gtttccccaa aacctatcgg aataaaaaat taaaaaaata catacataca 108906 aaaattcaga ttcccgacat aatatataaa tatatattat atgttatata taatattata 108966 tataaatata taatgtatta tagttatata taatattata tataaatata taatgtatta 109026 tatgttatat ataatattac atataaatat ctattaatat atattattta tattatatct 109086 aaatatataa tatataactt attattatat attataatat aacttatata ttatatataa 109146 tatatataat ataatataac ttattatata ttatatattt atatataaat aaaatatgta 109206 ctatattaat atatgaatat atctaatatt aatatacaat atataaattt ataaatatat 109266 aatgattata tattatataa tatataaaat atatattatg tagggaatct gaatttattt 109326 atgtatttat gtacatatat aaggtaggga atatatatat atgtattagg tagggaatat 109386 atatatatat atatatatct tctagagcat ttacaaagtt agtaatcaat ataatttaga 109446 aaagctaaaa tattaaacca caatgccatg aagtgattaa tcgacttatt cgtaagtgtc 109506 taatctgtga tgtgtatcat ttgtgtacat aggattaatt ataaataaaa aattactaca 109566 gtcctagagg tgtttatgct taataagtga gaaaatattc atattggatt ggagaaaata 109626 aatgttataa agccttaaaa ttctcatttt tattaaaagt atatacatgt atttttaata 109686 aaagcataca cacaccacag acatactatg cttaaagagg aattttgtat atgttccaat 109746 aagtcaacaa aaataatcat tgtcaaattt gtattgtatt tagttttcaa aatttttttc 109806 acatttgtat ttggagatac aactgagaat agcctcccat ttctcaggga acttacattc 109866 taataaggaa caaccaactg agtttatatt ttcttcccat tttaaccaaa gcattagttt 109926 ttaggttttc attgattcat gtcccttttt gtaaataaaa gtttagaaca acccaaatta 109986 attttgttaa ttagccagat gtaatcaagt caaataaagg gccttttaat aactgaacac 110046 ttgactttgg gtagcacaaa ttaagaaata gctaatgctt atttttctga gtacattaag 110106 tgaaattacg acttcacatt tggcatgtgt atacccatat actgagtaaa ataagttgtt 110166 aaatattatg aattattttt cccctttgca tacataatat gacaatgaaa tcatataaaa 110226 ggtaaatatg cactttgaag aaaagcattg acatgtatct tttttaaaag tccatcaatt 110286 gtaacgtaag gttttgttgt tttgactttc atcctag gt gaa att tat ccc aag 110340 Gly Glu Ile Tyr Pro Lys 220 atg tac cac atc tgt ttc ttt ctg gtg aca tac atg gca cca ctg tgt 110388 Met Tyr His Ile Cys Phe Phe Leu Val Thr Tyr Met Ala Pro Leu Cys 225 230 235 ctc atg gtg ttg gct tat ctg caa ata ttt cgc aaa ctc tgg tgt cga 110436 Leu Met Val Leu Ala Tyr Leu Gln Ile Phe Arg Lys Leu Trp Cys Arg 240 245 250 cag gtatatagtt tcaaatattt tgcgtgcatt attcctccac acataatttg 110489 Gln ttatttgtta ttccttccaa atattttgtc tgtgcttttt ttttaggatg cacttataaa 110549 caaaatttaa gaatgcattg aaccaatata acatgttcat aaaagtatta tattgtgtgt 110609 tcttttaaag taatgagaac ccagacatag aaatatgtct aggcattttt agagtaatat 110669 tcaggaaatg tattttataa actgattaag tactttacat tttaaataaa atttaacatc 110729 tgtgattaat tgtcttttgt ctaggaataa cactaatttc gctttctatg agaaatagca 110789 aataaaaatt cctttagaga tttttgagac tctaagtctg aaaggttata tttgtaatca 110849 gatttattta aaacattgga acatataggt taaatctcca acttcaaaga tcttattttt 110909 tagaatatta taagaatcag gcagaatgta taattttaaa aactgtatat aatgctgatt 110969 tggggttact acactttgtt agataattct gctgtatcag tgaatgtttg tattcattca 111029 ctcagttatt cattcctgaa atacatatca tgaacttttc acatacatgt ctcacacaaa 111089 agctaaaaat tctacttttt gccattgagg aattcatagt ctagaggagg ggcatcatca 111149 gatgcagggc gaaaattact ttaaatataa gcacagagaa tcagagcaaa atgtactaaa 111209 accatatcta atacaggaaa ggtaacattt aacttaaacc ttgatgattt gaaggatatt 111269 accaacaaac acatttagtg gtttgtaaga tagagacaaa aaggatatgg ctcagtctct 111329 cccattttgt aaaatgtatc ttaaaatgcc acaattctta gagatgtatt tctctcgttc 111389 tctaaactta ctgccgatac ttactttatc aggcttgtgg aaggacatgc cattagtctg 111449 ttttctctga cacattttat ccaactgaaa agatttactg gagtcacctt aattcattaa 111509 aaagatttca caaacacttt atttggtctt tgaggatgtg tctttgtttt tttaatcaac 111569 acttgttatt caaagcattt ttcaagatca tctttcactg actggatatg agcaacactc 111629 atttttttta acactatatg gctcataatt tcaatatttt ctcttttcct ctgctattac 111689 aaagaagtca tttcttttat gaccttacaa gtgaaaccag tagcaacatt tattaacatt 111749 ttgtttccca tcatttttta ctataaaaac taatgtggac cactataaaa tatgagtggt 111809 gattttctag atgttggtga cagttttctc agcactctcc acctccctat gaagccaatg 111869 cttatatttt agggtgtttg ttactgcagc atcctgcttc ctagtaccta ttattgtatc 111929 tgtcaggttt tgctaggtta ttattcttct attaaaaaat gtggtttgca acaacagttc 111989 tgtttcactc ctattacagg tcagtgggga gggctggctg gggcactgtg ctccatttgt 112049 tttctcattc cagaacctag tctgaagaaa tggcactttc tgggacatgg cattctgaga 112109 ctgagagaaa aagaaaactg gaagaaaagt atattttctt ttaatgtctt ttatgaaccg 112169 gcatgtgtta catctcactt ttcattggct aaaacaagtc acgtggttaa acttgatcat 112229 gaagagggga cacattcttc tctgacagaa agacatcaca catcacaggg taatggggag 112289 cttcctacaa gctggggatg aatgatctgg aatgatacac tatacagaag tcaaaaacac 112349 aagggccaga ctgcatgaat ttaaatcctg actccaccaa gtagtagtga catgaatttt 112409 gtaaatggct taaatttttg tgactccctt tattaacttt aaaatggggt tgtatagcat 112469 cttcctcata ggtttggtac atgcattcag gtgtgtccaa gggagagaac accgtcgtgg 112529 gttctcagtt tctatttcta tttgggccag taaaacccct tcctatccct cttttctgct 112589 tattactaga gacagaaact aaaaaccagg gcttcaggct gctaaaagcc taaaacaaaa 112649 caaaacaaaa ctacaacaac aaaataaggt gggttggaca agcttgctta gatgaattaa 112709 ctcaagtgcc taaatataga cagtgctcat taaacaaaat atcttaatgg atgttgttta 112769 ataatggcct ctcaactaat tgtacttaca tttaaatagc aagcatgtgt tgaattggta 112829 tatgtgacta ttttttaaaa aatgcacatt gaaataccag tatggtgctt cttatttgtc 112889 tggttcttct actctactaa gataaagata gtctcgctgt catctttgta tccctataaa 112949 tagcacgtgc tcagcacaca tcagttgctt ttttcataag aacaaagtga gtagaatagg 113009 agaaagtgct gggaaagttt agagaggaca tagagaatct attgcccagt tactccgata 113069 aacatttgta gaaatggatt agaatctgaa aaatttcttg aaggggaaaa agcaattaat 113129 gagcatgtag gaataaagat attttagatt tagattcaga ttttgttggg gaatgttcag 113189 tgttaagatt atcccctatt tccttatttt tactagttag tgtgcattgt ataaaaggta 113249 tgcttataat ttcttattca tttatttaca aattgacata cctttaaaac tctttcaagg 113309 ttgcaatgta tctgtcttgt tacttttaca tggtaaaact ttaccatgat accatggtta 113369 ccctaaagtt tacatggtac catcagagaa aatgttttaa aaagtttgtt aaatgaatga 113429 gtgacaccaa aatccaaaca ttttaatttt ccaccattta agcatatagt ttgacatttc 113489 ccaaactcta aaataaattt taaaataaat tgcatcacag attcataaat aatccacatt 113549 cttttcatga attatcctca ttagtacaag ccacatgatt cagaagattt gcagtaaaat 113609 gcttgggctg tgaaactaaa gtcatttaca aaacagattg gaatggaaaa taccaagttc 113669 agctgaactc actttagcag ccacaataaa gtgaattaac cccaaatgcg tgattacata 113729 gaattctgct tgagcaactc tcaatttcca actgttagtg tctataaaca aagttgtaag 113789 gcattatgcg tgccataggc tacatcaagt gagccatcaa atgaagagct tgtcctattt 113849 gcttaaaatt acagagatgc atgaaatctg ttatgtactt ttgaattagt aagtgtaaga 113909 ttattagtga gcaaattgtg tgtccttgtc tgactttctc aagaagttta agcctcatta 113969 aaagaattag ctaatgcatt gctgtgaact acttaaattc tctctctctc tgtttttttt 114029 tttttttttg gcaattcgac tcagagtact caggaaattc tacagattat ttgctaaaac 114089 ttattttttt aaagaactta gcttgcttga ctctttcatt tatctgtcag cattttttct 114149 agttcagacc cttcatataa ttcaacacta aatcttaatc gtcatgtgct tgtgttaatt 114209 tatttcacat ttattaagca cgtactctgt gtcagctatg gtgtgaggta ctgaggatgg 114269 actgtaatag atatttgggt ctgaaactat agttcagctt ctcagggcct ttgaaagacc 114329 ttcttgttcc cagctcttat cacaaagttt tctgctgctc tttattcagc actcttctaa 114389 gggaacttaa gataaataat atttgatgat gacaaatcag tctagtgtga gaaaataggc 114449 agcaaacaaa ttacaattgc aggggcagaa tcaggaaggc agtaactcga gtccatacaa 114509 aaaaaaataa ggagcaccag taaaggtaac tacataggta aatactgtag acagaataaa 114569 catatttatc ttctgttatc tgatgtaaag aacaactgca taaaataata gctataaaat 114629 tgtgaagatt caccttataa tgtatacaga tgtagttcaa aaaaggagga ggaaatggag 114689 ctgtattgga gcaaatttgt tttatactat tgaaattaca ttggcataat ctaagcagct 114749 tgtttagatt aagttgctaa ttttaattcc tggtgtaacc actaagaaaa taattttttg 114809 aagaatgtag aaatataggt aaagtaacaa aagaattaaa atagtataca gaaaatattt 114869 aacacaaaat aaagcagtag tgaggaaata gaggaagaca agagatacaa tatatataag 114929 tcacaaatag taaaatggca gatatatatt atattttctt aataattaga ttaaatgtaa 114989 atggatacaa tacttcaatc aaagggcata gattgacata atagataaaa accaaccaat 115049 aatttaaaaa aacccatgat ccaactttat gctgtctaca agagacatac cttgtattca 115109 gatatacaaa taggttaaat gtaaaataac agaagaagta ctaaaataat cacaaaaagg 115169 gagttaatgt ggttatacta aaattagaca aaataaattt taacaaaata ttactataca 115229 tagagaggga catttcataa tgatgatgga gttgatccat caggaagata taaaagttgt 115289 aaacatacat gcatttagcc actgaaaccc aaaatatacc aagcaaaaag tagtagaatt 115349 aaggagacaa gtaggcagct agacaattat agttgaaaat gttaatactc acttgcagta 115409 atggatagaa aacacaggca gggtgcggtg gctcacccct gtaatcccag cactttggga 115469 ggctgaggcg ggtggatcac gaggtcagaa gattgagacc atcctagcta acatggtgaa 115529 acctcgtctc tactaaagat acaaaaaatt agccgggtga ggtggggggc acctgtagtc 115589 ctagctgctc aggaggctga ggcaggagaa tggcgtgaac ccggggggtg gagcctgcag 115649 tgaacagaga tcgtgccact gcactccagc ctgggcaaca gcaagactcc gtctcaaaaa 115709 aaaaaaaaaa aaagaaataa agaaaaaaca ggcagaatag caacaaggaa ataaaagatt 115769 taaacaaact atgaaaccac tgggcttaac agatatttta gaacactcca ccaaaaacag 115829 aagaatgcat atttatccca tttgcacata aaacattttc caggttttct gactaaagtc 115889 agaaacaaga caagtatgtc tgctacaacc attttcattc aatgttgaac agaactgatt 115949 cttttcaggg caaacaggca agagataata ttaacaataa taaaaaataa aaggcatgac 116009 gatcacaaaa taagaggtaa actatttcta cttgtaggtt atgtgatatt ttatatagaa 116069 aatcctaacg aattattttg caaaaaaata cattagaaca aataaatgag ttcagctagt 116129 tttcaggatg aaagattaat atatatacaa aaatcaattt catttttata cattagcaaa 116189 taaaaattta aaatgaaatt aacaaaaaat aatttaaata gcatcaaaat taatcaaata 116249 cctagaagta gatttaataa aagaagctta ataagagact tcatccaggc ttgattgctt 116309 atgcctgtaa tctcaacact tttgggagac tgaggcggga ggatcacatg aggccaggag 116369 atcaagacca gcatagtcaa cgtggtgaaa ccatgtttct actaaaaaca caaaaatgag 116429 ccaggcatgg tggtgcagtg caagactata atcccagcta ctcaggaagc tgaggcatga 116489 gaatcatttg agcctcagag gtggaggctg cagtgagcta agactgcacc actgcactcc 116549 agcctgtgtg gcagagttag actcttgtca aaacaaaaaa aattcttcag cataaacatg 116609 tatatttagg gaatgtccag aaattataga gacatggatt ccatgcagca gttataattc 116669 cctaaaaaga gaattatgaa ttcactgtat tgctgaggat tctaacataa ccaccaaaga 116729 tccagggaga aaattaccct atttttgtat ttaaaaagat gcatttatta aatgatgtgg 116789 tactagtctc tatataggca acaaaaataa tgaaaaggaa atagctctgg attattaaaa 116849 ataaatagtc tgttaatcaa atcaattaaa tagataatgt tccttcaaca ttttcaagtc 116909 ctatacatga atatcattta caatcataat tattagcaac ttcaatgagt aggccacagt 116969 tatacaagtt tcttgagtca gtttggaact atttccattc aagcaacata tagtccattt 117029 ctgtaacatt ttgttctcca tcattatatt cagtctcaga aaggttacca acacagtcct 117089 tgaatcacat gtagtacagg ttaagcatct ctaatcccaa aacctaaaat tctagctgct 117149 ctaaaatccc aaacttttga gagctaacat gatgccagaa gtggaaaagt cccctgctat 117209 ctcatgtgac aggtcgtgtc aaaagtcaac aaaaactttg tttcatgccc aaaattatta 117269 aaaatgttat ataaatttgt ttaaagacta tttgtattgg gtgtttataa aatgtaagta 117329 agttttgggt ttagacttaa gtcacatcta caagatatct ttttatgtat atgaaaataa 117389 tccaaaatcc aaaaaaactc acatctgaaa cacttttggt ctcaagaatt tcagataagg 117449 gatattcaat cggtacacaa catatacacc tacaattaca aaatatcatt gaaaaaactt 117509 aaagaaggac tacctaaatt aaaagatatt ctgtgtttat ggattggaag attcaatctt 117569 gttaaaatag aaataatctt caaattaatc catgaattca atacaattcc tatgaaaatc 117629 ccagatggct ttgtattttg gacacaaatt gacaaactga tcctaatatt aatgtggaaa 117689 tgcaagggat agagaagagc caaaataatc ctgaaaaaga aatggaaaac ttacttccta 117749 atgtcaaatc ttaacaaaaa gccacagtaa ctaagacggt gtggtacttc catacagtta 117809 gtcatataga tcagtggaat agaattcatg gtccagaaat aaactcatat ttatgattaa 117869 ttgagtattg ataaaggttt taacacagtt caatggcaaa aatcatagtc ctgacaacaa 117929 atggtgttaa gacaattgta tatccacaag caaaaggatg gagttgaacc tcacctcaca 117989 ccacattcaa aacttaactc aaaatgaatc atagatttat atgtaagagc taatctctta 118049 gaagaaaaca cagaagaaaa tcatcatgac cttggcttaa ccaataggtt ctaaatataa 118109 caccaaaacc aaaagcaaca aatgacaatg tagatacatt agacattatc aaaacaaaaa 118169 cttttgtgct tcaaactgca ccattaaaaa cgttaaaagt cagcccatat aaatgcagaa 118229 aatatttgca aatcatatat gtgttaagga atttgtatcc agaatataca aagaactctt 118289 atgaattaat aatttaaaaa aattacaagt aggcaaagac ttgaataaac aattctgcaa 118349 agaagatata caaatggtca ataagcacat aagaaggtgc ttaacatcat tactcattag 118409 agaaatatta atcaaaatca tgagatacct attcacactc aacaggatag atttgtttta 118469 aaaggctgta atcattattg gtaaggatgt ggagtaattg gaatccttct acattgttgg 118529 tgggaatgca aaacgatgta actgctttgg aaaacagttt ggtagttcct taaaatctta 118589 gagaattacc acattaccca ctaattcaat ctctagttat agacccagag aactgaagac 118649 atgtttacac aaaaacttac acatgaatgt tcataacagc atataattca tagtagccaa 118709 aaagtggaaa caacccaaat gttatcaatg agtaaatgga ataactcatt gttctatatg 118769 caagcaataa aatattattc agctactaaa agaaatgaag cactgatata tgccacaaga 118829 ttgatgaatc ttgaaaacat actaagtgaa agaagccagg cacagaaggc cacatattac 118889 ataattctat ttgcatgaaa atgttgagaa taggcaaata tatagagcca aaataatttg 118949 tccttggcac gggctggcag aatgggacaa tgagaagtga ctgctaatgg atttggagcc 119009 tcatttggag gtgatgaaaa tgttctagat tagttagtga tgatgtgata gttgcacaac 119069 tctgtgaata ttctaaaaat cattttttga accccttaaa gcagtgaggt ttatggtatg 119129 tgaattatat cgcaataaaa tgttttcttt taaaaagaaa gaacaaaaat gatgggatat 119189 tttaaaattt taaaaattga agactttttt tttttttaga aagttctgct gctgaaacca 119249 cagggaagca aaaaaggttg aacacacaat ttgacatgtt aatgtaatga gagactataa 119309 taggaattat ccacgggttg ttttatctgt actttctgac taaagttttt ttccgtactt 119369 ctatagactt taaaatggtc catagatgtg caaaaaatga gagaacctat tccatgaaac 119429 catatatcaa gtcccagaga gcagagggaa aacctttttt tttttttttt tttgcaaaga 119489 agaagtcata gactgtgtga aagaataatg ttgcgagaca acagatctgg agttggacag 119549 gggcaggagg catagtgaga agatcagtta ttgcagttgt catccataag ggccatctgt 119609 acactctgaa agtggagcta ttcatagtga gaatgatgtt aagaaaagga acaaataaaa 119669 ttacagtcct cgttataaga atttagcatg caaatcttat cagagcagta ctgaggtaaa 119729 caaaaagtgt caagaaatca tgggatttaa tgtgaaaaac tccctcagtg ttggaataca 119789 gtcatcttca tatggtggtg ggtgtaaggg gcaaggaaaa ttttcatggt ccctgctgaa 119849 cagggaaatg taaggggatt attgtttcat agaagaccgc cagtgcctac caaatatctg 119909 ttatactcta ttatgatgaa atgggtaata ggttaaggaa taccataagg ggaaaggaga 119969 cttgtcctac aagtttctta gcacttagca aatggagcag gcatttgcta tgcattaaaa 120029 aataagcatc atccaaactc tcagactcat ccagccacaa acttaacttt ttgttcctcc 120089 tcctcccaga taaaattctc gacttatttc catttgtcat ctttttctca ctaaccgcca 120149 cctccactga tgtctcagcc cacttcagtg tagcttcagc tttcatcatt acagtgaaac 120209 agcttacatg aaagttacca atgatttcta aagaatatat atttttaaag tttatttatt 120269 gatcttttgg cagcattaag caatgttgtt tgtggtttca ttgctcatat actttcttcc 120329 tactttgatt tgaatacttt ttgctttgaa tacttacctt tccttccctg accagtaaat 120389 gccactttgc taggtctctt cacagctcca tgcttttttt caggtagtcc cttgcccagg 120449 tactttttaa gtgaggtgag tatcaaatat atatacacat cagactagtc ctctgggata 120509 cacacaatca caaatacact taaacactca atgtaccttt attataaatc ttgaaatgag 120569 tttttataag tcttgcaacc aaagtttaaa aaagaataaa ttcttttttt aaattgcttt 120629 ggctattcca ggtcttttgc actttcataa aaaattaaaa ttagtacttt catttccaga 120689 aaaaagactg tcgtggtatt gaacgtgatt aattgcatta actctataga tcaatttggg 120749 gagaattgcc atattaacaa tactaagcct tttaatgcat gtccacaatg aatatattta 120809 tttaggagtt ctttattatc tctctgcaat gtttcatcat tttcagtata tatatatata 120869 taatgaaata tatatactta tacatatatt ttatgaaata tatatactta tatatatatt 120929 ttatgaaata tatatactta tatatatatt ttatgaaata tatatactta tatatatatt 120989 ttatgaaata tatatactta tatatatatt ttatgaaatg tatgcctaaa acacattctt 121049 ttgatattga aacttttaaa atttaatttt ccatttattg ctagtatgta gaagtataat 121109 tgattttttt gtttattgat ttaatgacct gctccttgct aaattctttt ataagttcta 121169 gtgggttttt ggtagattct ttaggatgat ctttgtaagc aataatttct tctcaataga 121229 accaatctgt aggcatttta tttatttttc ttttcttctt gtattggctc aaagtccagt 121289 acaatgttga gtacgagtgg tgagagaaga cttgattttt tgagtggtaa gccaacactg 121349 cattgctaga ataaatctga ttgagcaaat ggtattatcc tatttatata ttgcaggatt 121409 taatttgata acatattttt aaagagattt ttatctctat tcatgaagga tatttagttg 121469 ttagctgtct tttgttgcca tatctttgat tacaaagata aatgtgacct catgaaattt 121529 gttggaacat attatatttt ctgtacattt cattaaaagt ctgaacaaga ttggaattat 121589 ttattcttta ctgtttgatt gaattcatta atggacctat ctgggcctgg agattttctt 121649 gtagcatagt ttgtaagtac agagtcagtt ttggtcatct ttgtctctca agggctttgt 121709 ccatttcatg taagttggca aattcattgt ttatccataa tgtttttaat gtttgtagca 121769 tgtttgcctc ttcctcataa ctttatcctg gtcacaaaca ttttttaaga cagagtaggt 121829 tttaaggtcc atcatgtaca tgctatttcc aattcataac tgtggtaata catttttcag 121889 ggtgtatttt tgcattaaat atgatttata aagtttattc ataatagtga aataaaagtg 121949 gggtgcatgt attttactta atccttctca gtgcctgctt gattgaaacc tctgagattt 122009 acaataatgt acttttaggg atgcattaag gattactagt gcatagttcc tggagctcag 122069 taatgtcagt tattcctctt aattttatac ggagtttctc tgaattctcc atgtctctag 122129 acagcttatc aatggagaaa tttatgtgtc ctcaaaatga atgcaggatt cagcatcttc 122189 tatccttatt tagatcatta tctaaaaagg gcatcactac attttttttt cccgatttca 122249 gggaccatag ctttctcttt atgaaaactg tatttttttt tttttttttg agatggagtt 122309 ttgctcttgt tgcccaggct ggagtgtaat tgtgtgatct catcggctca ttgcaacatc 122369 cacctcctgg gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggc 122429 atgtgccacc acgcccagct aattttgtat ttttagtaga ggcggggttt cttcatgttg 122489 gtcaggctgg tcatgaactc ccaacctcag gtgaccgaaa actgtttcta atggcggcag 122549 aagtcatcag atgcagaatg tagattctct ccttcagggg aacagtcagt gatagaatca 122609 ctaaaattta attgatctat cagagatcat ttagaagaca gacagttcaa gatcatttag 122669 cagacacata caggcttttc atgataggag tctcctggaa cattccagca tccattgctc 122729 attcttttca gttatttttt aaaattgctt tttaaaatga gagtcacaga agagaaagtt 122789 cctatctctc cccaaccagt gggttaaaag attgagttga accactacta tgtaaaaaag 122849 attgtctaca tgacaagaca tacagagtga gaagaaaaat aatttatccg atattttcca 122909 ttcaagggca ggtctttgtt aacatcattt gcctcttcaa gaaagaaaat ggtcaaagga 122969 aatgtcatat taatttatct gtgtggacat ataagtaaaa ttctgttctc aaattaaaga 123029 ttatcgaaca gactttgatc tggtggtgta aaaatcaaca aaatctatcg aacatctatt 123089 ctgagaaacc acaaggacac attggtcagt actggtttgc cgcacagaga cagaaagtaa 123149 aagctgaata atcttaacag agctaaggtg gccttttctt gtgtttgttg gcacattttc 123209 ctctttaaaa aattatgcat gctgaatttt attgttctgt tcactaaacc ctatcaatct 123269 tcatgagctt acaattaaga gaatattgta cttggaggga ttccctgcta ttatcaaata 123329 actttgaaaa gaaatggaaa agtacaagtt gtgtaattac tgttacaaat tccagctatt 123389 tgaaatatta atgtaagacc gcaaaaaatc ctcaatgggt ttgtgtgcat tttaaagggc 123449 tggaccacaa aactgatttc aaacaatttc ataactacaa atagtgaaca acaaaaaata 123509 cttgattttt taaaaatatc ctttcattca aaggtttgct ttgtccgaac tcgagaagca 123569 gaaaacctga aaagctacag gtagttaagt tctatctctc tggcagcaga tggcagtatt 123629 gatgcgtgaa aaatccataa caggttgctt gacgttactt gctgggtttt cctctgcttt 123689 aaactttggt atctgagctg aacaaaaatt cctaataaga taatatggct gacatccctt 123749 tatcattctc ctttcccaag ctttgttctt tttacaagga aatatctttt ccacttgcag 123809 ctttctttag acattgacaa aattttgatg ttttaacttt tttttccaca caaactccta 123869 tttggtattc gtctgaatta acgccaagca catactaagg tcagcaaatg ctctggagaa 123929 acaggcgctc aaacctccca cacctcaggc gtctggaagc ctttccttac tgtgttttct 123989 aattacttcc ccaaagtgga actttcctaa gtcaaattgc aataagggtc tgtctcttct 124049 cctttcag atc cct gga aca tca tct gta gtt cag aga aaa tgg aag ccc 124099 Ile Pro Gly Thr Ser Ser Val Val Gln Arg Lys Trp Lys Pro 255 260 265 ctg cag cct gtt tca cag cct cga ggg cca gga cag cca acg aag tcc 124147 Leu Gln Pro Val Ser Gln Pro Arg Gly Pro Gly Gln Pro Thr Lys Ser 270 275 280 cgg atg agc gct gtg gcg gct gaa ata aag cag atc cga gcc aga agg 124195 Arg Met Ser Ala Val Ala Ala Glu Ile Lys Gln Ile Arg Ala Arg Arg 285 290 295 300 aaa aca gcc cgg atg ttg atg gtt gtg ctt ttg gta ttt gca att tgc 124243 Lys Thr Ala Arg Met Leu Met Val Val Leu Leu Val Phe Ala Ile Cys 305 310 315 tat cta cca att agc atc ctc aat gtg cta aag ag gtaaaactta 124288 Tyr Leu Pro Ile Ser Ile Leu Asn Val Leu Lys Arg 320 325 tctgttattt gaaaatgaaa tagcctgcct tttcttgatt cttaattaac tttttttttt 124348 ttttttaact aagccagaga aaaatctaaa ctttctgctt agataccttg tcaggccaga 124408 tgactcagtt atgttgttac cagcaggtaa ggcgaacagc ctttaagagt gctcagacat 124468 gtgcttttgt catgcgtatt ctcagttgca tggcagacat aaaacagatg tttctccaat 124528 ctcttcaagc tagttgctaa accttagatg cagacaaagt tctaatgcgt aacaactcat 124588 ttacagcttg cagttctttc ttgatgagaa caaacgggtt tttcaaaact tcgtttccaa 124648 aaacataggc aattgtgaga gaattatatc ttaaggataa aaagagataa gaaccttatg 124708 ttagtattct aattatactt aaaagtgcat tggcgagcac tttttaaaaa aagccatcaa 124768 ggcagatatg tatgtcgaat gtctaaacag aagaattcat ttcctgaagt cactgaatga 124828 agctcagggc agatagtaat aaaaatcaat gagggaaagt atgctatttg ctacaatgca 124888 ggcacaacta ttaagttaaa aattttgacc catgacatga gcagcagatg cagaggcagt 124948 ggtacacact aaacttcatg gccagccaac tttattggga attatcgaaa ctgttccaca 125008 tagactggtc ccaaggcaat accaattctt gtttacaaca ggcttcgaac ttaagctaga 125068 attgctcctc tcactttggc ctgattcaga atcaatatta tattcctcac agctgggaac 125128 tctgaagaac agcagctttg gctggagtca gaagaagtgg tataatcagc cgcaaagggt 125188 tctcattctc tttggcccct gtttttgatg gtttaacggc tttttcaatg gagaagaaat 125248 ggagaacaaa cttctgttca gtgatactat ttactacagt cacagcctta aagatatatg 125308 attttttttg tggcctgggt ccttgagaca tatgccagct cacaagaaaa tagaaattat 125368 tttgccctcc atatcttttt gtgctttgct tcttattaat tattattatt attattatta 125428 ttattattgc taacagaaat ttaatacaaa tttattatgg ccacctgcta gatactctct 125488 tctgctttta agaactttat aaacatgtta tgttactgga tgggttttat tctttctttc 125548 tctttctaat cttttttctc ttttagtcag tctaaattca atgaaaattg gatttacctc 125608 tctctgggtt acgtatttgg atttcctgta tctcagaact tgctctttcc ttttatttcc 125668 aactactttt tttgtcaata atatatgtct tattcttctg actcaaatcc cttcctttcc 125728 aaggaaaaca aataactttc aaaggagcaa ggctgtgtta aatttaagat atttcaagtt 125788 ttggggcatt ctactctttt ccacaacata aaaacttttg aaaaaaagaa cttgaaaatt 125848 gtttttcttg ttaccacaca catttttttt caaatgctta tatttattta tccttgcata 125908 tgaaatttgt tttttctttc tcccacaaaa accattccta gctttttctc cttaaaactt 125968 aactttttgc caaattagtc aaaagcaatt tctttacaac agttcaggtt tgtccaagat 126028 ttcaaagaca ttttgaggta aagggtcata acatagtaca aatttctttt gtccgtatta 126088 tttcactcta tatagtattt ttgtaaaact ctagtactct ttataccaga aatggtataa 126148 ggtacacctt ataccagaaa tgcattgttg tcatgccttc ttgctgtaac acacacacac 126208 acacacacac acacacacac acacacacac actgatacag acaatcgaag atggagactt 126268 tagcaggaaa tatatatgat ttttggccta taatcttatt gagtagctgt aagttatctg 126328 ttataggtta gtgattagaa tttatagatg gaatatttct aagtatggag aaaatttttt 126388 aatagtcttt aaggatagca taacaaaaca ttttttaaag tttaaaataa tacatgaaaa 126448 attaacactc attaattttt aaaaattacc aaaattctgc ccatcgagaa ctgtttcttc 126508 tctgggtatt aaggagtccc agaaggcaag tttcagatag tccaggaaga ttggagttga 126568 aggcatatga tactttgatc aatacataaa tgaaagtagg aagaagtact tgaagactat 126628 catttaggag tgatttttaa atgatacaca taatagaata ttaatacaac attattcaat 126688 tgtatttaga aagaaaatga aataaagaag atatatattc aacttccata ttcttattta 126748 caagaaatac tgcatctgct atttgtggga gggagagacc cttctctgac ctgatttggc 126808 ttttgattta ttgattgtgc tgtggaggtt ctgttcaggc actgaagtta ttctaaacca 126868 attatggggt cagaaaccaa tctgtggtca attcctgcaa ctgaagagga caggagtcag 126928 accatcctct accaatagcc ttgttcacct ttgaatttaa ttatttaaaa gacacttttc 126988 tgttgtttct tttcctgcag a gta ttt ggg atg ttt gcc cat act gaa gac 127039 Val Phe Gly Met Phe Ala His Thr Glu Asp 330 335 aga gag act gtg tat gcc tgg ttt acc ttt tca cac tgg ctt gta tat 127087 Arg Glu Thr Val Tyr Ala Trp Phe Thr Phe Ser His Trp Leu Val Tyr 340 345 350 gcc aat agt gct gcg aat cca att att tat aat ttt ctc agt g 127130 Ala Asn Ser Ala Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser 355 360 365 gtgagttttc aactgttctt ccataagcca caattgtaac caaggatgag gaatcaatga 127190 acactcttca actatatgag gagtttagtt gctatgtgag ttgtattttt tccctgacct 127250 gatttatctt gagtttcttc tcttttgagg caaagtattt gttactgaac tcatcagaga 127310 aaatgaactg atttttccat gtcaaacgta taagaaatgt tataatagaa gaaaagtaaa 127370 cattctgaga aatcaataac acaaaatctt acatgacata ctttaaactc atgatttaca 127430 aaaatataaa atactttgtt ctgttttgcc ttgctatatt attcctttgc caaaatgtgt 127490 agcctaattg agacagaatt gggatctatt cacttttaga tattttacta tatttacgtt 127550 tctcttgtga gtatcatctc ttggatttat ctcaatattt cccactgact accaaaaata 127610 gtattactcc aaaataacac ataagttaaa tgatacacac atacatatac gtgtaactta 127670 tacaatttgt atctgtttat ggaatcaata taattataaa agtcatttaa atcactattg 127730 tttattcaca ttttgcccga ctgactttta gaattatttt taattagcta cctttttaca 127790 ttgccttaat ctccaactca ttggcgattt ctttgttatt tctatcttca aatatatggt 127850 gattttatgt ggaagaatag aaattcattt tgtggcatat ttaataaagc ttctgcatct 127910 tccaacttga tctttggcct tctggtttgc ataggtttaa aaaaaaggca acaaattaga 127970 ttgatgagaa ataattttgt tctatttaaa aaaaaatcta gcacaatgac taaagctctg 128030 aacctcgcac taagcaggta aaggctatga ggaagttgta atgagaagtg tttgaagcag 128090 aagtcacaga accaggtcaa agtcctagta tggaggataa aagtgagtta gaggaggcaa 128150 ctgataatca ctgataactc attatgtgac tgctattgtg ctgggcccgt gaacattcat 128210 cttctcattt aatcactgat aactcagtgc gtagctgagg ctaagagaga agaaatgatt 128270 cgcaatactg ccattcacac taataaaagt gattcattca ttctcatagt tctccaatat 128330 ctcctccata atttaaagac aaggaatagc ttctacagta tttttccccc ttcagttttt 128390 gttctttctt atatagatta tgaaactgaa aattttctgg atatttgagt gtatgtttct 128450 aggtattttg tggatttaat tgtttcagta tcagttattt agagtaaaat gcaggagtaa 128510 tttttgtata attttggctt tgtatgacat aagtttcatt gtgtttaatt attaaatatc 128570 tctgagagtt cttctactga tgatcacttc cattatagtt atgtagataa aatataccaa 128630 tatgcgtaaa tatatgaggt ttgactataa aggaatgaag caaattccaa gccccatatg 128690 tgaaaggcag cctcgttatt ttatgaaaat attcattgtt tcaagagtct accaagcttc 128750 caataaactc aatttcctta ttctatttta cccatctttg caaaatatta cacctcattg 128810 ttagtttggc tcaagggagc aactcagttg taccctattc ataatttgtt gaagcattta 128870 tgtataattc cttttccttt cattctctct gtttgccag ga aaa ttt cga gag gaa 128926 Gly Lys Phe Arg Glu Glu 370 ttt aaa gct gcg ttt tct tgc tgt tgc ctt gga gtt cac cat cgc cag 128974 Phe Lys Ala Ala Phe Ser Cys Cys Cys Leu Gly Val His His Arg Gln 375 380 385 390 gag gat cgg ctc acc agg gga cga act agc aca gag agc cgg aag tcc 129022 Glu Asp Arg Leu Thr Arg Gly Arg Thr Ser Thr Glu Ser Arg Lys Ser 395 400 405 ttg acc act caa atc agc aac ttt gat aac ata tca aaa ctt tct gag 129070 Leu Thr Thr Gln Ile Ser Asn Phe Asp Asn Ile Ser Lys Leu Ser Glu 410 415 420 caa gtt gtg ctc act agc ata agc aca ctc cca gca gcc aat gga gca 129118 Gln Val Val Leu Thr Ser Ile Ser Thr Leu Pro Ala Ala Asn Gly Ala 425 430 435 gga cca ctt caa aac tgg tag aatatttatt catatgacaa ggatacctga 129169 Gly Pro Leu Gln Asn Trp 440 gtaaaactat cctttttaaa atcactggga acagaaattt tattatccta tgatgtgaag 129229 ctaaaattac ttgtggatct tttttttttt taatctattg ctctttggaa ataaaaaaaa 129289 agtcagttta aaatgatttc tcaacttttg atttaaatat gttagaagtt taaccttcaa 129349 ttgagcttat ttcaggctat ttcactttta gtttcatgta ttaaaatgtg tgtcaattaa 129409 atgtttaaac atttctaatt ctttttataa tcccttgtta ttttaatctc tcacattcag 129469 attggttcct aaaaattacc agaatctatc caatgatttt ttttgctact aaaagaagta 129529 gcaattacta attctgaatt aacaatagac atgttagttg acttaatagt tttttttaaa 129589 aaaatcacaa gactgttgtt ataatgtgat atctgagaaa atatttatat ataaaatagc 129649 atattgtgtt aggtaattca aaaactatct tacaaaacta tatactcact catttacaca 129709 attttctcag gtttgcaaat tgaccattgc taacatttct tgtctcaaca tatggccagt 129769 aagactctat cacagtaaaa gttttaacgt aatttccatc tctaacactt taacatttaa 129829 gaataagcta aatcacatca ttatattctt ttaacaacaa caacaaaaag tgatatagtc 129889 agccttgctg gattaaatta aaaatgcacc actgtgctag gtgctaggga atgagatggc 129949 gtcgatgcaa acatgccttc aaaagagctt cagtctagtg agggagacat gttgacagag 130009 tgcaaggcag caaacaatct gggggacaat tcttggtcat ggcagagcag tgaagctacc 130069 aaggacagtg gtcttcacca gaaagtttgt agcgcagttg cacttttttt ttttcttcaa 130129 tttaattaca atgacagttg atgtcagtgg attccatctg ggcctggggc tgagtaccag 130189 gtggttaaaa aatagagggg cttgctctta actcacacat acatgaatag actatcgtat 130249 attttgtaga aaatgtaaga tctgggagtc aaagcactga gtattcaaac ttattcccct 130309 gaaaaattct tctgattcaa atatttactt gaaaattaaa ctaaaagtaa aagaagtgtt 130369 tatgaaagat gattttcatc tcctattatg gtaacaggtg ttctgattgt attgaaacaa 130429 aagatatggg gcacagtgtt taagaaaaac tttcatagaa aattaatttt tgttattttt 130489 tcatttttcc attacactca gagaaaagta aaagagccta attatccaca acttgttttc 130549 aaatcttgga atttgggatt ctgttacctt gtgcctttta tgactcaaag caaaaactat 130609 cttcttatac aaggtttatt gagatcatat tgtaaaatat cagcactata tcagtgaaag 130669 caaggtattt taactctctc ctttctcccc tttgtatatt ttagaacttc ttttcttatt 130729 tatgctgcat gaaaggagag ttgtaatttt cggatcgtga tgacagcact ttaaaaagtt 130789 tgaggataac ttcaaataac gttgataata tgccttaata gccagtaata gctcagagga 130849 agagtaaatt ccttagaccc aaatatacct acttataatt taaaagagag aaaagggaga 130909 gagattgaga gggaaagggg gagagaagga aaaaactgac tcagagagca gcagttatgt 130969 gacgtatggg aagtcagaat tcctttgctc taaatcagtg attctcaaaa tgtggtttct 131029 ataccatcgg catcagcatc atctgggaac ttagtggaca tgctaacttc caccctatcc 131089 ctcacctact taaccagaaa ctttaggggt gatagcccaa aagctgtgtg ttaagcacta 131149 caggtgtttc tgaagcactt taagatttga gatccactgc tttaagtgat accatctgac 131209 atcagtttat ctgcctgtgt gaaataaagt cttttactgc acaggtgtct acaacagggg 131269 ccaccatcat cgctaccgtc aacgtggttg gatgtctgaa agaagaagct gagtatcaat 131329 gttgactctc actcatgtca tcttattaaa aaaaaaacag tttacaaaac aattgctact 131389 gataaatgca gtgtgaaaga ctggttttaa ggcacttgtg tgctttatgt ccacccagat 131449 aacttgagtt tttaactaaa agtttcaaat ccctatcttc tttatactta ctaaagttcg 131509 ttttgcagaa gcagatagtt tctaagaatg atcatttcat ggaaggagat ataaaataaa 131569 ataaaaccag tacttaaact ctgggaatgt aataggccat gtacatagca ctcaacatgt 131629 gaatccagga atccttctaa gaggtctaga tttagtatgg ttaccttaat aggacaaatg 131689 gtaaagaaat aggtgttccc aaactctgcc aatcttatga aacaaagagt caactcttta 131749 cctcattatt tgctaatgac acaaatgcaa agacatcttt tgaaaagaat gtgttgggac 131809 tgttttatgc tgtaccttga atgtgtatct ctcctttttt tgctatattt caaagattta 131869 atgtaagttg tcaatgtcat tgagttcttg ttatcaatag ggatgatata attttatcta 131929 acatggaatc cattttaact ttgttatttc tgaatttcta tgaaaccaca aaaaccttca 131989 tacttgaatt tatttattct tggctaaaga ttactcccag tttgtgagga aatttatttc 132049 tgagtttcca aagcttggag aatttattgg atattaaata cctgttataa attattgatg 132109 agttaattgc aagtagcaga cacaatgata ttgaatttca ctcccaatac acattgtttt 132169 aatgaagatt aaggtaaata tgtttataaa atttagtctg gctatgctta aacctgaaat 132229 agcagaatgg caaaaaaccc caaagctgtt tatggaccca aattgtgagg agggctatta 132289 ttttaatact tgtgtaataa tagaatgcac ttgatgtaaa ttgtaatagc catcaactgc 132349 atttcaaaaa cctttcgcta gccactacaa tttagaaagc ttttcagtgt cagttagttt 132409 tacaacaaat gccttttcta ctttctacaa gtcacaagtc aaaaaaaagt aaattccacc 132469 aagttttatt caattagttt tcaaattgca tgaagcaaaa aatagatttt tagagacaat 132529 atataaatag aaaaaatatt gtaaaagtct actctattac cttatgtacc acaaaaaaat 132589 aaagtacaaa ggcatgaaaa acactattat ttcccaaagt tcaaagggaa ttgttttcta 132649 cgcaactact gctactaaca aggggacaac aaccccctcc acttgccacg tatttttatt 132709 ctcttttctt tatatctttg gagttaaatg tcttttatgt ttttcatgaa atgtattcta 132769 taattgttgt atttcatgtg tgtaacatta tgtcagttgt tttaacaatt atcttatatc 132829 ttgaaattct ttatgcctga ttgtactgtg tcttcatgaa gaaatttctt atcaaatcca 132889 atgtgattac acacttactg ctgtaaagga tgcgcattat gtagttttta agtaaaaact 132949 atagtgagaa ttctataatc acattcacac tcccctctct attgtatgaa aaatcttgtt 133009 gttgttgatt agataaggtg gatattcact catagttaat gtcaaatctc tgcagttaag 133069 gattgaatta agccctctgg tgcagtacct aatgatcaaa acattttttc caataagttt 133129 atataaccaa ggataataat gatataaaag gtttttaatg ttgtttttaa gagcaggtac 133189 tataacaaag aaggttaaca ctggtacaga aatatttcat aaaagttatg aaaaccagat 133249 aaatacagta ttaaattttg gagcttttat ctgagttgag agatttagtc tacattgact 133309 gagatgaaat gatgaactca taattttcaa tttattatca gaataataag tgacatttac 133369 ataattaatt tttttctggg ccattttgta taagtcattt aggactattt taagttcact 133429 ggtaaatttt aaaatgtata ttttcagctt ttcaattttt ttcaaaatag ttctgagaaa 133489 ttacagaatc agatactaag gatattaatt taaaaatcaa tttttattca gcactattta 133549 ttctaacata tataaaaaat gaagccaaag taacccgtca aggtaaatac ttgactccta 133609 ggaaaatgtg attttagtag gcatctcaag aggaagtgaa acttctcgtg gtgaaattac 133669 aagaaaaaca agttattcag tggtgagaat gtgttgctct aagcaatcca ttagcacaga 133729 ctagctactt ggccactcct cttccttctg gagccagccc tgaagagtgg tcacagcatc 133789 ttcattttta tccaggccaa tggccatgca tgagaagttg ggtagcaaaa ttcttgaagc 133849 acctctttgt tcttgctctt ctttcactgt tttctcactc tccacctgta atgctcactg 133909 ccagttttac caccaagcta agtatcagca gacctccctc cacagcgtgc cttgccctgt 133969 agaactcctg gtccttcctt cagcccaacc ccatccaatt gcctaggttc ttgttgtctc 134029 ctgagatgaa caagaggcaa gtagctaatt tgagaacaaa tgaagcagag ctgaaggaaa 134089 aagtaaaaca tttatttttt catatcccaa attttataat tttacatttt tttaaaaccc 134149 attcattttc ttcccagaac atttatgctt atcagtggtc ttctgaatct gtgacaactc 134209 ccttttcaag ccccagctaa gcttcttgcc tcaagccaga aggaatccca gttttgagtc 134269 ttgtgttaag gccatggcag gtcagtaggg agattatctg aggaggtacc gcttgtgaca 134329 ccttcagaaa caaaacagct attgccttac gtttcatagg cccaggccct gagcaatagc 134389 aaaaagataa tacttatttt tttaaactgt tgtttattag gtgatcgatt tctaattaat 134449 ttcaaaatat ttaaggtaat attttaatta ccgaggaaga atggtacaaa caaaatgttg 134509 tggaactgga aaatcctcag tgcttgacaa catgaaactt atttaactta ttatagatga 134569 gataatgaga acatcttcag aaaagaagct atgttcctta aaacaggggt acagatttaa 134629 aagctctgtt tatatggttt tggtagacta agtgaagaac ttgcctataa agctgagtct 134689 cgatcatata gcatatccat tataaagtga gaaaattgca attttagagt attgtcaata 134749 catccaaaaa tttttacatg atttctaaat gcagatgtgt gtgtgtgtat gtctacgtat 134809 gtctctccat atgcaacaag cagttaatta gtccaaatat atcccacagt gtagattagt 134869 ttcatatctc agctcttcaa tgtctcttct tcatttaatt cactccttgg tgtctagttt 134929 tcctcactct tttacaaata tccaggttct atatttctgc ttttctagag agctttttcc 134989 ctcaagaata tatttttctt tttctttctt tctctttatt tttgtttgtt tttaactaac 135049 attcatatgg ttataacaat ttgagacaag tgaaaaggaa agatctgtaa actgcctatc 135109 tcctttgaaa ttcattgcca ataatcctta agaatataaa gttccttgat gccaaagacc 135169 ttctcattag tgttgctgcc tgttgtttca ttggttccct agaacaatgc ctggcacata 135229 aaagttattt gataaatatc tctgctatta atgaattaat aataactgca tgacaattct 135289 ttcctcaatt catcattttg cttcattttc tcacagttgc ttcaatgtgt ctgtggaact 135349 atctttccat gtgaacaaaa cactctacat tctcagtgtc tacaaagcac atatttcctt 135409 ttattaaaat taaactttga gagcaccaaa tcctaatgtc taaccatcat caaactggca 135469 gatagcacca gtattctttt tgctcaccaa ttttatgccc aggcatctac tgtttctttc 135529 atgaataaaa cctgacacct gtaagaggat ttatcatggt aaacttctct ttgttactga 135589 cattttcagc ctcttgggct ctcccctcct tacttataca cattggcacc cagcttgaag 135649 tcatactctc tagaccctgg gtcaatgtgg gtaatgcatc caggaatcca gcttaactct 135709 tccttggtct ctttgatgtg actgaccttt atttctacat ttcttcatca aaccagtctc 135769 acagttttgc acagtgcaaa tcacatgctg caccatgtgc ttattatctc ctataacaac 135829 agatgctcca ctgaaatgca aaactctgtg ttaagccaac aactgcttct ccatcctttc 135889 ctcctatacg tttcttctca ctacaacttc ccttctcaac cccaaaggga ctactggatt 135949 ctttactctt ttattttacc ccagtctatc agtcccatcc tggacttcct tccttctctg 136009 cttagaggaa agcaagatga tcaggtagaa ttgcacttat gactagatat tatttacttc 136069 aaacaaattc ttactatttt gtcctgatga aattcatgac agttttcata caacagaaag 136129 cctgccctct tagaagagaa gagaactgaa aagaaatggt tgaagtaagg tagaaagccc 136189 tcatggagtt aggtggctag gccagcagag ctaggcactg ttctcctgtt cagaattgca 136249 ctcctgatac tccagatggg aagcctgcca tggcactaac cacagcactt tttataccct 136309 atctctgcta ttatgagccc acattagttt ttcttctgct tcagaaattg ttgcaaaaaa 136369 taattttatt atttacaaat tatttttaaa ccatataaat ctgcttagtt tgatttctca 136429 aaccctctaa aacttacact tcttgttgtc caatctttgc ttttaattgg gtataatttg 136489 aggcagaaat aaattaatct catttttaaa aatgtactag ctattaataa tttttaaatt 136549 tatcttctaa aattggaaag tatccacttt aaatgcatct gtagcaagga ctttttacat 136609 acattctgta gctttattac ttccattgag aactgttaaa ataacagaac ttacctcact 136669 gtacgctggc ttttgaaaag gcagcagaac tgtttatctg attatcgaag taatcatatt 136729 acatttcttt ttcttttcta agagaaacct tcttcatgtg ctcagtcaaa cattttggtg 136789 tttaagaatt gacttattag gtcaggcgcg gttgctcacg cctgtaatcc caacactttg 136849 gaaggccgag gcaggtggat cacttaaggt caggagttcg agaccagcct ggtcaacatg 136909 gtgaaacccc acccctacta aaaatgcaaa aaaaaaaaaa tagcaaggtg tggtggtgca 136969 catctgtaat cccagctact tgagaggctg aggtgggaga atcatttgaa ctcgggaggc 137029 ggaggttgca gtgagcagag atcacacgac tgcactccag cctgggcgac aaacaagaat 137089 ctgtctcaaa aaaaacacaa aaaacaaaaa acaaacaaaa aagagttgac ttagttaatg 137149 aaaatatttt tattaggaaa ttatacttct ctttacaaag tatgtattat ttgttgcatc 137209 tatatagtct atcaattcta aaagcacact ttatgcgaaa atgtagtcta ggccttcaga 137269 atgtattatt acaagaaagt atctatcaac catgtttcat ttgtttgcat gttttgtttt 137329 gtttccaata gactatgaat attcagcttc aaatgctacc tcatgattgt tacattcctg 137389 ttgttgaaag aacccatctc tttcttacct tcttgtccct aaattgtgtt cttcttataa 137449 cttactttgc acataaccat aatggagtga gatcatagaa ttaagaggat tgagaaagaa 137509 aaatacttcc ctcattccat tggcagtaat ctgtgattca aaagttaaca acataccatg 137569 tattcttgta ggagattatt tcatgcttat cactgatcaa cttacatgca ggttaaaacc 137629 agccctgaaa aaatgctcat catcactggc catcagagaa atacaaatca aaaccacaat 137689 gagataccat ctcacaccag aagaatggcg atcattaaaa agtcaggaaa taacacttgc 137749 tggagaggat gtggagaaat atgaacactt ttacactgtt gctgggagcg taaactagtt 137809 caaccattgt ggaagacagt gtggcaatta ctcaaggatc tagactagaa ataccatttg 137869 acccagccat cccattacag ggtatatacc caaaagatta taaatcatgc tactataaag 137929 gcacatgcac acatatgttt attgcggcac tattcacaat agcaaagact tggaaccaac 137989 ccaaatatcc atcaatgata gactggatta agaaaatgtg gcacatatac accatggaat 138049 actatgcagc catctgagca aactatcgca aggacagaaa accaaactcc gcatgttctc 138109 actcataggt gggaattgaa caatgagaac acttggacac agggtgggaa acatcacaca 138169 ccggggccta tcatggggtg ggggtaggag ggagggatag cattaggaga aatacctaat 138229 gtaaatgatg agttaatggg tgcagtactc caacatggca catgtataca tatgtaacaa 138289 acctgcacgt tgtgcacgtg taccctagaa cttaaaatat aatttaaaaa aaaaagccct 138349 aaatgcaact tgttcagata actggagcca tcttcctagc tctttatttc tcagacagtg 138409 tgggtaagtc ctgctccgta cgaatgctta tgtcagtttt gaagttcagt actttcttaa 138469 gagccagagt cagtcaagat gttcccttaa caagattttt caatggggtt acacattaat 138529 gagttctttt tcctccttta agtatttgaa aattttggtt taataaaagg tttaactatg 138589 atgaatttag gatccttttt cctgttacag agcacagaat aatagttaat attttacata 138649 catattgcaa gttcatgttg ccactaggag tgtccagaat agacaattga aacagccttc 138709 tagctactac tatcaaaaaa gagctttaaa taacatattt taattaaata acattatttt 138769 ctatagctat acctcaataa aaccatcaac caatgtttgt acaatttgat gcccccactc 138829 taagattttt agctagtgta aatcagagtc tcctatttaa tgagacactt tatccaatca 138889 ggttgtgttt attattcaac cagatgatct tggaacttat aacaaactag taatacttaa 138949 agctgggctt tatgtgcgtg atttactggg atgtttgctt ataccttgtt tccaagctaa 139009 aaatattgtg accaggtgtg ttagtctgtt ttgagttgct atataggact acctaatgct 139069 gggtcattta taaagaaaag aggtttattt ggattatggt tctgcaggct gtacaaagag 139129 catgacatca gcatctgctt ctggtaatgc cctcaggaag cttttactca tgccagaagg 139189 caaggggagc cagcgtgcca catggcaaga gagggaggaa gcacaagaga gaggagacgt 139249 accaggcact ttttaacaac cagctctcac atgaactaac agagtgataa ctcactcaat 139309 acccggggga tggcaccaag ccattcatga aggatttgcc ctcatgacca aatacctccc 139369 actaggccca acctccaaca ctgggggtct catttcaaca tgagatttgg aagggacgac 139429 tatccaaact atatcatcag gattttctgg catggactac caagccattt ctgcttcaaa 139489 ctcccctgaa attcttgtta aaaatgcaga ttctttgata ccacccccaa tacactattt 139549 agtctgagat gaaactcaag gattctgatt taattgatct agactagcat ttgaccattg 139609 atttatcatc tgggattcta ggaagtcaac cacttatatg ttttagagca gacttcatta 139669 taattgagga gaatgtttgt agtctgtggg ctcctctgtc cacttctgat tggggcccct 139729 ttgcctgatt ctgactggat caggcagagt tttattcaag ccactgtcct ttttggcttc 139789 ttaatgttca aaatatatta acacaatctc agttttctaa gagctaaatt atacgacttg 139849 gttcttgtct ggtaacataa ctgcattact ggatcttgtc aagattcaga gacattctcc 139909 cagtttcaaa tttgtaacta acactgtttg atcacaaaaa agttctaagc caaagcaaaa 139969 ctctttctac caccaccaga tggcgttact ttggacttac ctataaatgg atttccaaat 140029 ggtttttcag aaaccaactg gaggtactta gaaaaactta tggaactcac aactattctt 140089 tgcatgtcaa aagctataac agtaaataat atttgtggag aatattctgt aagattaggc 140149 tgcctttctt ttcctccagc ttatttaaac tatatcctta tattaaccct tgttggagat 140209 gtgtcctctt attgcactgt atgtgagtgt gtgtgtgtgt atcccatcac gttggtatga 140269 tgatagcacc cttcattgag aagctttgca aaaagaatat aagaacatgt tattatgttt 140329 acttaaaagt ataaggccgg gtgtggtggc tcacacctgt aatcccagca ctttgggagg 140389 ccaaggtggg aggatgacga ggtcaggagt tagagaccag cctgaccaac acggtaaaac 140449 cctgtctcta ataaaaaata caaaaattag ccaggtatga tggcacgcat ctgtaatcct 140509 agctactcag gaggctgagg cgggagagtc ccttgaaccc aggagacgga gtttgcagtg 140569 agcctaggtg gcgccactgc actcaggcct gggtgacaga gtgagactcc atctcaaaaa 140629 aaagaaaaaa gaaaaaaaag tattgaggac attgctcatg acattccaag gttatataaa 140689 agaatatata aaaagaaatt tctgcctgga cttagtgcca ggaatacttg tacttttctt 140749 gctttcttct taagaacatt gcacaataga gtatttttaa aaattgtgct tgctgttcaa 140809 attgcctgct ggaaggatta gaggcagatc tgtagcatgc cgagtcccat ctttgcatac 140869 aggctatcat gacaaacatt gtatgtgcta attctatctg gcttctcttt atattcctat 140929 ctgtctctat ttcctgtcat tttaatgttt taaaattgta ctttttactt aaatggtttt 140989 tggaagaaat aaatataagt aaagtctgtt agaggcccgg cgcggtggct cacgcctgta 141049 atcccagcac tttgggaggc caaggcgggt ggatcacaag gtcaggagat tgagaccacc 141109 ctggctaaca cggtgaaaac ccatctctac taaaaataca aaaaaaaaaa aaaattagcc 141169 aggcgaggtg gcgggtgcct gtagtcccag ctactcgaga ggctgaggtg ggagaatggc 141229 atgaacccag gaggtggagc tcgcagtgag ccgagatctc accactgcac tccagcctgg 141289 gcgacagagc gagactccgt ctcaaaaata aaaaaataaa ataaaaaaat aaagtccgtt 141349 acaaagcaca aaaaagaacg gcaaagccaa caaacatatg aaaaaaagct catcatcact 141409 ggtcattaga gaaatgcaaa tcaaaaccac aatgagccat catctcacgc cagttggaat 141469 ggtgatcatt aaaaagtcag aaaacaacag atgctggaga ggatgtggag aaataggaac 141529 gctttttaca ctgttggtgg aggtgtcaat tagttcaacc attgtggaaa gcagtgtggc 141589 gattcctcaa ggatctagaa ccagaaatac catttgaccc agcagtccca ttactgggta 141649 catacccaaa ggattataaa tcattctact ataaagacac atgcacatgt atgttttttg 141709 cagcagtact cacaatagca aagacttgga accaatccaa atgcccatca gtgatagact 141769 ggataaagaa aatgtggcac atataatata cagcatagaa cactatgcag ccataaacaa 141829 aggatgaatt catgtccttg gcagggacat ggatgaagct ggaaaccatc attctcagta 141889 aactaacaca ggaacagaaa accaaacacc acatgttctc actcataagt ggcagttgaa 141949 caatgagaac acatggacac agggagggga acattacaca tcggggccta ttggggaatg 142009 ggggctaggg gagggatagc attaggagaa atacttaatg tagatgacgg gttgatgggt 142069 gcagcaaacc accatggcat gtgtatacct atgtaacaaa cctgcatgtt ctgctcatgt 142129 atcccagaac ttaaagtata ataataaaaa aaaagaaagc acaaaaataa aagtacttgg 142189 aaaagtttaa agggttaaat attatgcaaa actgaaaact agcttcagat acatttaagt 142249 ttatatcatg ttaacaagtt atttctttct aaaaaattct aacctgtaac acagagagtg 142309 gacttgaact tgaaaatatg gttaaggtac aaatgcagat ttggggtccc agtctcccag 142369 actgtggctt ctatggaaga gattgtactg gctccaaatt ccacagatga ttgaacaact 142429 tgtttctgcc tgtgtcagag ctgaagagtg aatatctcca ctatatatat ctcaaaatct 142489 cccaaatgaa atttggtaac cctctatgcc ataacacatc acattaataa tttgtattca 142549 aaagtctctc agaaaagatt tttgaaatgc cagatacttt aattttttta tgtttatata 142609 tttagggtgt atgagtacag atttcttaca tgcctatatt gcatagtggt ggagtctggg 142669 cttttactgt agtcatcatc tgaacagtga acttgtacca aataagtaat ttttcaactc 142729 tcatccaccc accctcccat cttttgtagt acccaaggtc tattatccca ctctgtatgc 142789 ctgtgtacct attgtttagc ttccacttat aagtgaacac atgcagcatt tgactttctg 142849 tttctgagtt attttactta ggataatggc ctccagttcc atctacatgg ctgcaaaagt 142909 tatgatttta ttctttttta tggctccatt atatgtatgt gtgtgtatct caattttctt 142969 tatcaaaccc tctgttgatg gacacttaga ttagtccaca tttttgctat tgtgataaac 143029 atgtaagtgc aggtatcttt gtaatataat gatttctttc cctttggata tataccaggt 143089 agtgggattt ctggatctaa tggtagttct atttttagtt ctttgagaaa tctccatact 143149 gtcttccata aaggttgtac tagtttacat ttccaccaaa agtgtataag cattcccttt 143209 tctctgcatc ctcacaaaca tcctttgctt attgactttt taataacagc cattctgact 143269 agtgtgaaat aatattttat tgtgatttta attttctctg atgattagtg atgttgagca 143329 ttgtctcaac atcactatgc tagtggcatg catgttttct tttgaaaaaa agtttgtgtt 143389 ctttgcccac attttaatgg ggttatttgt tttttttttt ctttgagttg tttgagttcc 143449 ttgtagattc tgaaaattat tcctttgtca gctgcatagt ttacaatttt tttcccattc 143509 tgtagtttgt ctgttcactc tgttgattgt ttatttttct gtccagaaac tttagtttaa 143569 gtcccatttg tctatttttg tttttgttgc atttgccttt gaggactagg tcataatttt 143629 ttgcctgggc aaatgtcctg aagatttttt tccaggcttt cttatagtat ttttatagtt 143689 tcgggtctta tgtttaggtc tttaatctat cttgagttaa tttttgtagc tggtcagagg 143749 taggtgtcca gtttcaatct tctacatatg gctatccagt tttcccagca ccatttattg 143809 aatagggagt catttaccca gtaaatattt tagttgactt tgttaaaaat cagttggtta 143869 taggtgtgtg gttttatttc taggttctct atgctgttct attcatcaat gtgtacattt 143929 ttatactagt accatgttgt tttggttact atagctttgt agcataattt gaagtcataa 143989 tatgatgcca acaactctgt tctttttgtt tgaaattgct ttggcttttt ttccttgtga 144049 gagtttgctg agaatgatgg tttccagctt tgtccatgtc gctacaaagg acataatctc 144109 accctttttt atggctgcgt agtattccat ggtgtatatg tgccacattt tcttaatcca 144169 gtctatcatt gatgggggga gggggaaggg atagcattag gagatatacc taatgtaaat 144229 gacgagttaa tgggtgcagc acaccaacat ggcacatgta tacatatgta gcaaacctgc 144289 acattgtgca catgtaccct agaacttaaa gtataataaa aataaataaa taaaataaaa 144349 taaaattgct ttggctttct ggactctttt ttttggtttt atatgaattt taggattttt 144409 ttctaattct atgaaaaatg gcattggtaa tttgataggg attgtgtcga atcagtagac 144469 tgctttagac agcatggtca ttttaataat attgaatctc taatccatga gccagggata 144529 tttttccatt tgtttttgtc atctagggtt ttcttccatc agtgttttgt agttctcctt 144589 atagatatct tttacctctt tggtgaaatg tattcccagg cattttactt tatcttatct 144649 ttttgtagct attataaatg gaattgcttt cttagtttgg tccttggaaa tgccaactac 144709 atttaaaatc cttttccatt tgatggattt caggtcttga tgaacatctc agttgtaatt 144769 ttcttaagat tgaaaaagta aatatttttt ctatatgtat atataaaatt gtcctctctc 144829 aaaattttaa ttcaataacc tgctagatat cactttagaa tcttgcagta ctagttttct 144889 tctcaattaa ttgtagatct tagcctttta atttgggcat gtttttccct attaggactt 144949 aagttattag gacctaagtt tgtagacaag aactatgtta tatttgagaa atttgtgagt 145009 catgtactgg gcctagcaca gtgcctcata agatgtagac cctcaataaa cttgttgaat 145069 aggttaataa ataaaaaagc ccctatcact caattttttt tttttttttt ttagatggag 145129 tctcactcag tcacccagcc tggagtgcag tggcacgata tcggctcact gcaagctctg 145189 cctcctgggt tcacaccact ctcctgcctc agcctcctga gtagctggga ctacagacac 145249 ccgccaccat gcccgactaa ttttttgtat ttttagtaga gacggggttt cacctgtgtt 145309 agccaggatg gtctcgatct cctcacctca tgatctgacc ccctcggcct cccaaagtgc 145369 tgggattaca ggcatgagcc accacacctg gcctatttca gtcaattgtt aaaagtgcta 145429 agaacaagtg gagatcttgt taatgaagaa aaaaaaaata gtatttacta cttacctaaa 145489 cactctacta agaagggata tacagatcaa aaggattaaa tctctgcctg cattaagcta 145549 actgttttgt aaagaagaac gtaaacaaag tcaaaaatgc attttttagg tgctagagat 145609 tagacaggac aaaatcttct ggctctgcct agagttaagt ggctttggga gaggctttgc 145669 tgtagtttaa aggcagaggt ggggaaggcc actctggcca caaggacaga tccacaatgg 145729 gatggggtat gaaacagcac gaacccttca ggaaattaca cataatttaa aaggaaaatg 145789 ggagcccatg gcagaaaata gaattgaaca gcaggaaaag ggtagatagt aaaaagcatt 145849 ttataatatt caaggacatt tgaaacttgt ggtatacaat gaggaagaat ttaaaaattc 145909 tatacagagg agtgacatag ttagatttgt gttctgggga gcataataat agcattacag 145969 cgggtgaatt tgaaagctgg gcctcaaaag tttagatctc aaataggttt ttatgggagt 146029 attcatcctc atgaaacatg atttggaact aaaccaaggc agtggcaatg gggctggaaa 146089 ataaacacta gatttcatat ctagatgaag atttgtggaa taagagaggc cacattaatg 146149 tttaattcta tttacaatgg atcccagcca ccatccgctt taacacagag gtgcttttcc 146209 agtagctaag aggactaggt gctttagata catttgtgaa gttgtcctcc cattgttaac 146269 atgctttttt tattgtctgt gtgtaggttg atgggggagg cagagttagg atcacacata 146329 gaagttcagt ctttgaaatg ctttctttct ctttttcccc aaacaatgac ccccaccttt 146389 tccttctggc atatgttgcc tcaagaccct aacactgctg ccaatctgct ggtcttagag 146449 ccaagaatct gccaccacct ggcccaccac agcctgctct gctagctgct ctcctgccaa 146509 tactggcctt catgtacaag tgtaggtttt gagggttccg ttctctcccc ctttctctct 146569 ttgagtgtgg gtttgtgagt gtgtgtgtct tctgtaataa gaagaaaaca ggccacattt 146629 tctctactcg tgttatacac ttcccggagt gtctcacatc aaaacctgtc ctaagtccaa 146689 gccttagaag ctctttgctg gcccagccta cacttgggtt gttacttctc aggagctacc 146749 tttctgtcag ttgagatttt aacaacccac cacagtactc caagcgtgca gtccctcaca 146809 tcttgaaatc tgtgctttgg cagcagcaga atcaggggtc tgtggattct gaacccagaa 146869 tgtgtcaaac caaagggtga catattggga catttaataa gtcagagact atttcccagg 146929 aatatttttt tgaagcattt aaactaaaat acaattgaac tgagatctca aaacaggaaa 146989 aatgaacttg acaagaatta ggctaagctg catctcatga cgtaaatatt cacatttgca 147049 tatacattaa cagagtcaag tcaaaaattg attttttatt ggataggatt aactttagct 147109 acagaaaaca gaaagtttaa atgactggct ttaaaaagca aaagtttact tgctttcatt 147169 tatatgcaat ctggggggtt gcgggggaag atttgtttgt gggtttccca ttctcaaggt 147229 gccaggctcc tgtgtttctg ccccatatcc ttagagggag ggtttcctcc tcaggattgc 147289 cttatgtgca aggtgactac tgaagctcca ttttttatgc ccaaattgta gcaagaaaga 147349 gaaaaggaag aaggaacaga aaggcacatg acatcacttc aaataaaatt agggggaaaa 147409 taataacaga tatctgatag gaaactaaca gtaccttctg caataatgat tacatttctg 147469 gaaaataaat gttaagatcc ttgaaaacaa ggagtaatag ttgaggaaaa gcttcttagc 147529 agcctgggac taaaaacttc aaaaaattta agataaaaat ctgaaaactg gtagagaatt 147589 ggggagaaaa agagaatttg aacaaggcat gcaagagtaa gaaaaatgtc atcacaaaat 147649 tactaagaaa gcataaaagc aactatattt tattagagta aaaataaatg gattgaataa 147709 ccctagtaaa ataaattcca gccatacatt gtttataaaa agtgtattta aggtgattag 147769 gaaaaaataa aactaaattt aagtgcaaag atctcccagg gaagtcaaag caaaaataaa 147829 gtcagatgtt gctgtcatta gacaaagtaa aatttaaggt gaaaacatga caaagaggga 147889 cattaaataa ggataaatgt acaatcaatg gtgacaaact tttataaact tgaaattata 147949 ttaacaaaac ataaatcatg taaaactaaa ataccttgat aaaatgcaaa ttatcaggta 148009 acaagaatat atctattgca gaaagtaata tatcaaacta aaataatgtg tatctattac 148069 aagtatacaa tactttgtag cctacaaaat aagaatatac gatttcttct taaaatgtta 148129 tacatttaca ataattaata atttggccac tcagaaaacc ttggtaaagc aaggaaagta 148189 gagatattat aagccaactt aataatttag taacattggg taaaaatgga agaagtatca 148249 tattgtggtt gtgaacataa gctctagttc tcctagtttt gtgatttggg aaagttaatt 148309 atcttctctc tacctcgtct taattttcag taatattagg ataacaatag tttgtacatc 148369 atcagtgttt tttttttttg aggaataaat gactcacatg tattaaacac ttagatccat 148429 tgttaacata taatatgtat aaataatgtc agtataaatc aatgtcagcc taaaaagtta 148489 agactgtgat tttaaataat actagattta gaataaaatc aaaattgaaa tgacattatt 148549 aacttaaaaa taacaaaaaa agagaagact ttaaacacaa tggatggaaa gcagctatac 148609 caataaaaga caaaaatgtg gagtattata tgttcttaat gttttttaaa attataaaaa 148669 taaataaact aaaacataga attttaaaaa ttaaatgttg gagggattag gtcagataag 148729 agaaatttct gttagcagca gctgaatttt ctgctaataa cagagaattg tgaaaagatg 148789 atttcataaa tatggcaaat gtttgtaata gccatcctag gagcacggat attagtaact 148849 aattgaggaa gtactgttgg gcagtgtcaa tatactggtt aagaatagaa tttaaaataa 148909 tgctaattat aaggccaaaa aactcagtaa tgcaattttt ttagtataat tcagtagggg 148969 agaaggagag ataattaaac ttggaaattg acatacagtt gtcccttggc atccatgagg 149029 aattagttcc aggactccct atggatacct aaattcacaa atgctcaggt cccttatata 149089 aaatggcaaa atatttgcat ataacttaca cacaccctct ttataattta agtcatttct 149149 aaagtactta taataccgaa tgcattataa atgactgtgg aaatagttgt tgtattattt 149209 agggaataat gacaataaaa aatatatgta tatgttcagt aacagatgcc ttttttaaaa 149269 aaaaattgtt tttgatccac agttggctga atctatggat acagagccca catttactga 149329 gggcagacta tatttagagt acttaaggat cacaagggac acacatctga gggtactgaa 149389 gagtgggaag aaattactaa ccagagggtc agactagaag gcaaggaagt gaagccagga 149449 gatgattaga aaataagaaa atcatacaag cctggagatt atgttgaagt gtaagaacat 149509 aattagagtg agaaacatga gtcaaggaag aaggagattg gtgcttgaga gatgtggcag 149569 actgtatctt tcaaagatgg ctacaccaat atatatctca ttccacaagc tgtttttacc 149629 atgctgtatt gacgctcttc catatggagg tggggcctat gtcccctccc ttgaaaccaa 149689 atgaaacttt gtaattgcct tgatcaacag attgcagtag gagtgatgct ggatgatttc 149749 aaaggctaat acacacaaga aaataatggc tttcatttga ctctttcttg gaacatgtgc 149809 cttggaaacc atgagcttat ttgcaagaag ctcagctatc ctaaagttta tctactgggt 149869 agaccaagtg gagaaattac acagacattg agattatgtt caaggggtct cagaggttca 149929 aggcctccca attcaggcac caaacaagtg gagaaaaggc tttcaagatc atccctctga 149989 aataattgtc tgattgaaac ctcaaaagag tccctgagcc agaaccatcc agccaagcca 150049 ctctcaaatt ccaaatccac agacaccatg aatgacagta aatcattatt gttgttttaa 150109 agcacataag ttttgggggg ttatttacac acagcaacag aaaaaaaaac tgatgaatgg 150169 gaaacatgga gagaaatgca aatagaataa aatgggaagg aatacaagga gaggaaagta 150229 gtattgtgca aaataggcaa tcggatgacc ctcaaaagga aatttttttt ctgagcaact 150289 taatgaatat aaggtcagat taaattggaa ggtaacaggt acaaatatca ttaatgctaa 150349 attctatttg tagtaagtca actatttgta aattatgcat tggagaccga ctttacatca 150409 atcaaaagtt aaatttattt agaaatctat agaagaagaa aaagaataaa agccattgga 150469 aaagttttta caattattcc attaaataga caaagtcctt taaggaaagg gattaaaatg 150529 aaggtaaggt gatctgctta aaaataatat agcaatctgg gagccatggc tcatgcctgc 150589 aatcccagtg ctttgggaaa tctaggcagg aggacctccc aaaggaggac ttggagtttg 150649 agaccagcct aggcaacaca gagagactcc atctcaaaat tttaaatttc ttaaaagaaa 150709 aaaaataaaa tgaaataata ttgtattaat tccagtaaaa gcatcagacc aatttagaat 150769 atggatgaga gagaaaaact agaaataaca ccacaacaag gaaggagaaa gctggtctct 150829 ggcagggact tctaatttag agaaagacag atgatagcaa acagcaaaag ttgtattata 150889 gatgtaactt aaaaactaat ttgattttta tttttagtca gaaaactgct ttaggtatgg 150949 aacaagtata acctggtatt tccagtatct ctctgttgac ctcacatctc tctccagata 151009 ctgcctcaat tctctgcttc tctttatagc aaattccctt gaaagagaga ctacctggat 151069 cagaaattcc tctgcttcaa tttgatcctg aatccacttc atctagatct tcctcaccaa 151129 ttcccccaaa tatttgtctt attatggtca catgggacct ctactttgct atatcagtaa 151189 ttttgttctc attttacttt tttgtagtta attactccct tctccttgaa acactttcct 151249 tgtttggctt ctaggatgcc ctgttctcat ggatttcctt tcacttctcc agtcatttct 151309 gtttgttttt tcaatatctt cgtgatctta tatttttaat gcgtcctgct agcttcccaa 151369 ctaggtttcc tactttcacc ttaattccct atggtttatt ctctacaaga aaggaattat 151429 aatcccttaa aaatgtcaat aaaactctat cactactcaa tactctccaa ggggtcctta 151489 ttttattcaa gtaaaaaact aaagtcctta ctatatgtct gtaaattccc ataggatctg 151549 gccccacagc ccctctggcc cctgtccatt ctgccccttg ccaattctgc ccggccacag 151609 ttgcccaata gctggtctgt gaacacatca agcacatact taatctcaag gcttttgcaa 151669 tcattctttt ctctagttgt aatctctcat tacttattct gagtgtcttg tttctgcagt 151729 tgctttactt acttgaccta tataaaatag taattcttac ccctacaact ccattatgtc 151789 ctatcttctt tgccttgcct tatgtttttt tcttggagtt acagatacct gatgtagata 151849 gtatttactt tttttatgct tgcattaatc acctagaata taaactccaa aagaggagct 151909 atttctcttt tataatctat ctaatatatc ttggatattt gctcccacct aaatttcatg 151969 ttgaaatgta attccctgtg ttggagatgg ggtctggtgg gaggtatgtg gatcatgggg 152029 cggatccctc atgaagggct tgggccatcc ttttggagag aagtgggctc tggctctgac 152089 ttcacacgag atctggttgt ttaaaagtgt gcgacagctc ccctgagctt cctctctcac 152149 ttgctcctgc ttttgccatg tgaagtacca gctactgctt cattttccac catgagtaaa 152209 agatccctga ggccctccct cagcagtaca tgtccctatg cttgttgtgc agctggcaga 152269 accatgagcc aattaaatct cttttctttt aaattactca gtctcatgta tttctttata 152329 gcaatacaag gttggcttaa tacatatctc taaagcaaaa gctgggcctg gtatgtaata 152389 ggtgttcaat aaatatttat tgaataaatg aataaatact aggctaaata aagtttaaaa 152449 catcataata gaacactggg tagatgtcaa gatgacagtt ttgttattca catatggaca 152509 tggaaaggtc tttgtggtgc attgttaagg gagcaaacca aattacagaa cactatatag 152569 agtagagctg tataaaatac atatggtgta tgtttataaa tatgtctaga aaaatttgaa 152629 agctatatat caaatatcat atcatttatc tttagaaggc taattgcata ttttcaattt 152689 attgtttata atttttttta tctattatta taggttactt gtataatcac aaaagacaac 152749 tgaataattc tttttgtctt catcaacttt tattttaagt tctgggatac atgtacagga 152809 tgtgcaggtt tgttacatag gtaaacgagt ggcatggtgg tttgctgcac agatcgaccc 152869 atcaccgagg tattaagctc agcatccatt agttattcct cctgatgctc tccttcccct 152929 tggcccacca atacacccta gtgtatgttg ttacccctca tgtgaccatg tgttctcatc 152989 attcagctcc cccatataag taagaatatg cagtgttagg ttttctgttc ctgtgttagt 153049 ttgctgagga taacaggttc tagatccatc catgtccctg caaaggacat gctcttgttc 153109 ctttttatgg gtgcatagta ttccttggtg tatatgtacc acatgtacaa ctaatttcca 153169 caacaaaaaa tgtactatta catggatata atgtttatat tctcttcaca gaatttgagt 153229 cacttgaatt tttgctttaa cacttagaat ttggagggtc tgttttctta aaaaaaatta 153289 acactttaaa tccaataagt aaatgtggaa ggttggtgga aatagttagc tggaaactca 153349 gaattgatat taactttcac caagcctttg ttcacattat tttcttctac aatttatgaa 153409 tgaataatcc tgcactatct atgcattcaa acaatgatac atatggtgca tatgtatata 153469 tggcaaaaat ctaagaaatg tagccaaata ttaatattgc ttacacgtaa gtagtcaaat 153529 catggtggtt tttttttatt ttcttgattt tgcaagaaaa ttaataaaga ggctatttac 153589 attttaatgt acaaatgtgt atacaaatat aatagttatg ctttaaaaat ccaataaata 153649 aatgtaagta aaacatttct gaatttttta aagatttctc aatagatcta ggtattcttc 153709 ttaaccaaat actgatacta ccgttaacca cttctggaaa attctggcaa ttggtccctt 153769 tggggaagaa ctagaggaat cactactata cacacttact gtggtattca gtgcccttcc 153829 tcaaggggaa ttcgcctatc ttttttttct taagtaatat tttatcttta atagacaaat 153889 aatggttgta tttatttacg ggatacaaag tgacattttg atgcaagcat accttgtgga 153949 atgatcaaat caggctaatt aacatatctg tcatctcaaa tgcttatcct ttcttcattg 154009 tgggagcact taaaatcaat tcttttagct atttggaaat ataaaatata ttattttcta 154069 actatattta cttacgatgt agtgtaatag atcacaagaa cctatttctt ctatctaact 154129 gaaactttgt actctttgac caacatctcc cctttctttg tccatcctcc tagcccagcc 154189 tttggtagcc atcactgtac tctgtatttc tatcactttg cctttttaaa ttgcacatat 154249 aagagagatc atgcagtatt tgttgctttg tgtctgactt atttcctgta gcagaatgtc 154309 ctttaggtta atccatgttg tcataaatga caaaatttcc tgcctttcaa aggctgaata 154369 gtattccatt gtttatatat accacattgt caaaatccat tcatctgttg atgggcatgt 154429 aagttgtttt caaatattgg ctttattaat aatgcggcag tgaacgtggg agttcagaca 154489 tcttgttgac atactgatat taattccttt gactatatac tcaaaagtgg aattgctgga 154549 ctgtgtggta attttagatt tttagtaaca ttcatactgt tttccaaaat aactgtatga 154609 attaacaata ccatcaacaa tgtacaaggg ttccctctgc tccacatcct catcaacact 154669 tgctagtttt catgttttcg ataatagcca gtctatcagg tgtaagataa tatttcattg 154729 tgatttaatt agcatttctt tgataatcag agattttgag ccttttttaa tatatctgtt 154789 gaccactttt atgttttcct ttgagaaatg tgtatttaag tcgtctgccc atttttaata 154849 ggatcatttg ttttcttatt attgaggggt ttgagttcca tgcatatttt agatactagc 154909 cttttatcca atgcgtaatt tgcaaatatt ttctcccaat ctgtgggttg tctctttaac 154969 ctgctaactg tttcctttcc ttcctgcaga agctttttag tttgatgcaa ttccatttgt 155029 ctatttttgc ttccattgcc tgtgcttttg gggttaagaa atctctgctc gattacattt 155089 attgatttgc gtatattgaa ccagccttgc gtcccacgga tgaagcccac ttgatcatgg 155149 tggataagct ttttgatgtg ctgctggatt cggtttgcca gtattttatt gaggattttt 155209 gcatcaatgt tcatcaagga tattggtcta aaattctctc ttttggttgt gtctctgcca 155269 ggctttggta tcaggatgat gctggcctca taaaatgagt tagggaggat tccctctttt 155329 tctattgatt ggaatagttt cagaaggaat ggtaccattc ctccttgtac ctctggtaga 155389 attcggctgt gaatccatct ggtcctggac tctttttggt tggtaaacta ttgattattg 155449 ccacaatttc agagcctgtt attggtctat tcagagattc aacttcttcc tggtttagtc 155509 ttgggagggt gtatgtgtca aggaatttat ccatttcttc tagattttct agtttatttg 155569 cgtagaggtg tttgtagtat tctctgatgg tagtttgtat ttctgtggga ttggtggtga 155629 tatccccttt atcatttttt attgtgtcta tttgattctt ctctcttttt ctctttatta 155689 gtcttgctag cggtctatca attttgttga tcctttcaaa aaaccagctc ctgaattcat 155749 ccattttttg aagggttttt tgtgtctcta tttccttcag ttctgctctg attttagtta 155809 tttcttgcct tctgctagct tttgaatgtg tttgctcttg cttttctagt tcttttaatt 155869 gtgatgttag ggtgtcagtt ttggatcttt cctgctttct cttgtgggca tttagtgcta 155929 taaatttccc tctacacact gctttgaatg tgtcccagag attctggtat gttgtgtctt 155989 ttttctcgtt ggtttcaaag aacatcttta tttctgcctt cattttgtta tgtacccagt 156049 agtcattcag gagcaggttg ttcagtttcc atgtagttga gcagttttga gtgagtttct 156109 taatcctgag ttctagtttg attgcaccgt ggtctgagag acagtttgtt ataatatctg 156169 atcttataca tttgctgagg agagctttac ttccaactat gtggtcaatt ttggaatagg 156229 tgtggtgtgg tgctgagaag aatgtatatt ctgttgattt cgggtggaga gttctgtaga 156289 tgtctattag gtctgcttgg tgcagagctg agttcaattc ctggatatcc ttgttaactt 156349 tctgtctcgt tgatctgtct tatgttgaca gtggggtgtt aaagtctccc attattattg 156409 tgtggtagtc taagtctctt tgtaggtcac tcaggacttg ctttatgaat ctgggtgctc 156469 ctatattggg tgcatatata tttaggatag ttagctcttc ttgttcaatt gatcccttta 156529 ccattatgta atggccttct ttgtctcttt tgatctttgt tggtttaaag tctgttttat 156589 cagagactag gattgcaacc cctgcctttt tttgttttcc atttgcttgg tagatcttcc 156649 tccatccttt tactttgagc ctatgtgtgt ctctgcacgt gagatgggtc tcctgaatac 156709 agcacactga tgggtcttga ctctttatcc aatttgccag tctgtgtctt ttaattggag 156769 catttagtcc ctttacattt aaagttaata ttgttatgtg tgaatttgat cctgtcattg 156829 taatgttagc tggttatttt gtttgttagt tgatgcagtg tcttcctagc ctctatggtc 156889 tttacaattt ggcatgattt tgcagtggct ggtactggtt gttcctttcc atgtttagtg 156949 cttccttcag gagctctttt agggcaggcc tagtggtgac aaaatttctc agcatttgct 157009 tgtctgtaaa ggattttatt tctccttcac ttatgaagct tagtttggct ggatatgaaa 157069 ttctgggttg aaaattcttt tctttaagaa tgttgaatat tggcccccac tctcttctga 157129 cttgtagagt ttctgccgag agatccgctg ttagtctgat gggcttccct ttgtgggtaa 157189 cccgaccttt ctctctggct gcccttaaca ttttttcctt catttcaact ttggtgaatc 157249 tgacagttat gtgtcttgga gttgctcttc tcgaggagta tctttgtggc attctctgta 157309 tttcctgaat ctgaatgttg gccttccttg ctagattggg gaagttctcc tggataatat 157369 cctggagagt gttttccaac ttgcttccat tctccccgtc actttcagat acaccaatca 157429 gacgtagatt tggtcttttc acatagtccc atatttcttg gaggctttgt ccgtttcttt 157489 ttattctttt ttctctaaac ttcccttctc acttcatttc attcatttca tcttccgtta 157549 ctgatatcct ttcttccagt tgatcgcatc ggctcatgag gcttctgcat tcttcacgta 157609 gttctcgagc cttggctttc agctccatca gctcctttaa gcacttctct gtattggtta 157669 ttctagtttt acatttgtct aaattttttt caaagttttc aacttctttg cctttggttt 157729 gaatttcctc ctgtagctcg gagtagtttt atcgtctgaa gccttcttct ctcaacttgt 157789 caaagtcatt ctccattcag ctttgttcca ttgctggtga ggagctgcgt tcctttggag 157849 gaggagaggt gctctgcttt ttagagtttc cagtttttct gctctgtttt ttccccatct 157909 ttgtggtttt atctactttt ggtctttgat gatggtgatg tacagatggg gttttggtgt 157969 ggatgtcctt cctgtttgtt agttttcctt ctaatagaca ggaccctcag ctgcaggtct 158029 gttggagttt gctagaggtc cactccagac cctgtttgcc tgggtaccag cagcggtggc 158089 tgcagaagag cggattttcg tgaaccgcga atgctgctgt ctgatcgttc ctctggaagt 158149 tttgtctcag aggagtatcc tgccgtgtga tgtgtcagtg tgcccctact ggggggtgcc 158209 tcccagttag gctgctcggg ggtcaggggt cagggaccca cttgaggagg cagtttgccc 158269 gttctcagat ctccagctgc gtgctgggag aaccactgct ctcttcaaag ctgtcggaca 158329 gggacattta agtctgcaga ggttactgct gtctttttgt ttgtctgtgc cctgccccca 158389 gaggtagagc ccacagaggc aggcaggcct ccttgagctg tggtgggctc cacccagttc 158449 gagcttcatg gctgctttgt ttacctaagc aagtttgggc aatggcgggc acctctcccc 158509 cagccttgct gccaccttgc agtttgatct cagactgctg tgctagcaat cagcaagact 158569 ctgtgggcat aggcctctcc agcatataaa cagaaccaaa gacaaaaacc atatgattat 158629 ctcaatagat gcagaaaggg cctttgacaa gattcaacaa cgcttcatgc taaaaactct 158689 caataaatta ggtattgatg ggatgtatct caaaataata acagctactt atgacaaacc 158749 cacagccaac atcatactga ataggcaaaa actggaagca ttccctttgg aaactggcac 158809 aagacaggga tgccctctct caccactcct attcaacata gtgttggaag ttctggccca 158869 ggcaattagg caggagaagg aaataaaggg tattcgatta ggaaaagagg aagtcaaatt 158929 gtccctgttt gcagatgaca tggttgtata tctagaaagc cccattatct cagtccaaaa 158989 tctccttaag ctgataagca acttcagcaa agtctcagga tacaaaatca atgtacaaaa 159049 atcacaagaa ttattacaca ccaataacag acaaatagag agccaaatca tgagtgaact 159109 ctcattcaca attgcttcaa agagaataaa atacctagga atccaactta caagggacgt 159169 gaaggacctc ttcaagggaa actacaaacc actgctcaat gaaataaaag aggatacaaa 159229 caaatggaag aacattccat gctcatggtt aggaagaatc aatatcgtga aaatggtcat 159289 actgcccaat gtaatttata tattcaatgc catccccatc aagctaccaa tgactttctt 159349 cacagaattg gaaaaaacta ctttaaagtt catatggcac caaaaaagag cccgcatcac 159409 caagtcaatc ctaagccaaa agaacaaagc tggaggcatc acactacctg acttcaaact 159469 atactacaag gctacagtaa ccaaaacagc atggtactgg taccaaaaca gagatatagc 159529 tcaatggaac agaacagagc cctcagaaat aatgctgcat atctacaact atctgatctt 159589 tgacaaacct gagaaaaaca agcaatgggg aaaggattcc ctatttaata aatggtgctg 159649 ggaaaactgg ttagctatat gtagaaagct gaaactggat cccttcctta cagcttattc 159709 taaaattaac tcaagatgga ttaaagactt aaacgttaga cctaaaccat aaaaacccta 159769 gaagaaaacc taggcattac cattcaggac atagacatgt gcaaggactt catgtctaaa 159829 gcaccaaaag caatggcaac aaaagccaaa attgacaaat gggatctaat taaactaaag 159889 agcttctgca cagccaaaga aactaccatc agagtgagca ggcaacctac aaagtgggag 159949 aaaattttcg caacctactt atctgacaaa gggctaatat ccagaatcta caatgaacta 160009 aagcaaattt acaagaaaaa aacaaacaac cccatcaaaa agtgggtgaa ggatataaac 160069 agacacttct caaaagaaga catttgtgca gccaaaaaac acatgaaaaa atgctcatca 160129 tcactggcca tcagagaaat gcaaatcaaa accacaataa gataccatct cacaccactt 160189 agaatggcaa tcattaaaaa gtcaggaaac aacaggtgct ggagaagatg tggagaaata 160249 gaaacacttt tacactgttg gtgggactgt aaactagttc aaccattgtg gaagtcagtg 160309 tggcgattcc tcagggatct agaactagaa ataccatttg acccagccat cccattactg 160369 ggtatatacc caaaggacta taaatcatgc tgctataaag acacatgcac acgtatgttt 160429 attgtggcac tattcacaat agcaaagact tggaaccaac ccaaatgtcc aacaatgata 160489 gactggatta agaaaatgtg gcacatatac accatggaat actatgcagc cataaaaaag 160549 gatgagttca tgtcctttgt agggacatgg atgaaattgg aaatcatcat tctcagtaaa 160609 ctattgtaag aacaaaaaac caaacaccgc atatgctcac tcataggtgg gaattgaaca 160669 atgagaacac atggacacag gaaggggaac atcacactct ggggactgtt gggtgggggg 160729 aggggggagg gatagcctta ggaaatatac ctaattataa atgacgagtt aatgggtgca 160789 gcacagcagc atggcacatg tatgcatatg taactaacct gcacattgtg cacatgtacc 160849 ctaaaactta aagtataata ataataaaat aaaaaaataa agaatagaat aaataaaaac 160909 aaaaataaat aaaaaataaa aagaaatctc tgctcatatc caggccatga tggtttcccc 160969 ctgtgttttc ttcaagtagt tttatagctt caagtcttat gttatattaa gtctttaatc 161029 cattttgagg tgattcttgt acaaaggctg aagtaagggt tcattttgat tcttctgtgt 161089 gtgtgtatcc agttttccca acaccattta ttgagaagtc tgtcatttcc ccatggtgtg 161149 atcttgttac ctttatgaaa atttaattga ccataggtgt atgggtttat ttctgggctt 161209 tctatcatat tccattgatt gatatgtctg gttttatgcc agtactatgc tgctttgatt 161269 actgtggatt tgtaatgtaa tttaatgtct gagagtgtga agcctgcagc attatttttt 161329 ctcaagattg ttatctgtgg ctatttgtag tcttttgtgg tttcatatat attttacaat 161389 tttttatttc tgtgaaaaat gcattggaat tttcatatgg attacattta atccgctttg 161449 ggtagtatga ccattttaac aatattaatt gttctaatcc atgagcatgg gctagctttt 161509 catttatttg tgtcatcttc aggttttttc aacaatgttt tatagtttta gtatatggat 161569 ctttcacttc cttggttaaa tttagtccta agtgtgtgtg tgtgtgtgtg tgtgtgtgtg 161629 tttgtgtgta tgtgtgtgtg catcaactaa ccatagtcat gtgggtttat ttctgggctt 161689 tctatcatgt tccattgatt acttctaagt gaatgagtgt gtgtgtgtgt gtgtgtgtgt 161749 gtgtttaaga tactgttgta attttaaaat ttctttctca ggttgtatgt tgttagtgta 161809 cagaaataat attaattttg taagttgatt ttgtattctg caaattcact aaatttgtta 161869 atttgtttta acaatttttt gggtgtagtc ttacagggtt ttctatatat aagatcatgt 161929 catcagtaaa caatttcatt tattcttttc ctatttggat gctttttatt cttacccaat 161989 tgttttgact aggacctcca gtactatgtt gaacataatt gatgaaagca gacatccttg 162049 tcttgctcct gatccaaaag cctttaactt ttcaccactg agtatgatgt tcactgtagg 162109 cttgttatat atggtctttg ttgtgctgag aaacattcct tctataactg attttcaaaa 162169 gtttatcatg aaaggatgtt aaattatttc aaatgttttt tcttcatcta ttgaggtgat 162229 tatattgttt ttattcttca ttctgttact atggtgaatc atatttttaa ttgtttttta 162289 cttgcataaa tttattttgt gataggtaga aaagcacatc tgcagaccta gaagcagagt 162349 gaatctaaaa aatattattt ataattatta tgagtacaca ataggtatat attttcatgg 162409 ggtacattca atgttctgat acaggcatat gatgtgtaat aatcacatca gggtatttgg 162469 agtattcatt acctcaagca tttatcattt ctttgtgtta gggaatttca gtttcattct 162529 tctagttatt taaaatatac aatgaattat tattgactgt agtcaccctg ttgtgctatc 162589 aaatagtatg tcttattcat tttatttaac tatatttttg cacccattaa caatccccac 162649 ttgatttgaa tatggtaagc cattcttgca tcctaggaat aaattccatt tgaccatggt 162709 gaatgatcct tttaatgtac tgttgaatat agtttttggt attttgttga ggatttttgc 162769 atccatgttc atcagcgata ttggcctgta atttgctttt ccggtagttt cttgtttttt 162829 tattatactt taagttttag ggtacatgtg cacaacgtgc aggttagtta catatatata 162889 catgtgccat attggtgtgc tgcacccatt aactcatcat ttaacattat ggaaaatctc 162949 ctaatgctat ccctccccgc tccccccacc ccacaacagg ccccggtgtg tgatgttcgc 163009 cttcctgtgt ccatgtgttc tcattgttca attcccacct atgagtgaaa acacacggtg 163069 tttcttagtc tggctttggt ctcaggctaa tgttggcctt acaaaatgat tgtggaaata 163129 tttccttctc ttcaattttt tgaagaagtt tgaaaataat tattaccagt tcttctataa 163189 atgttgggta gaattcattt atgaaaatat cttttcctgg gttttccttg atggcggact 163249 tttcattact gatttaattt ccttgctcat tactgttcca tttatattcc tcatgatttg 163309 atcttggaag gttatgtatc gaagccttta tctatttcct ctccatcgtc caatttgttt 163369 gcatgcaatt gttcgtagtg gtctcataag atcctttgta tttttgtact atcaattgtg 163429 atatcttttt tcatttctgc tttagtttac ttgaaccacc tgtattttct cgtggttaat 163489 ttagctaagg attgtcaatt ttgtttgtct ttttggaaga ccaacgctta gctttactga 163549 tctcttgtat tgtttttcta atttctattt cattgatttt tgctctgaaa tgtttccttt 163609 cttccactaa ctttaggctt agattgttct tcttttacta attcattgag gagtaacatt 163669 aagttgttta tttaagatct ctctctcctt ctctcactct ctcttttgat gtaggcattt 163729 agtgttacaa actttcctct tagaactgct tttgctgaat cctgtaagtt ttaatatgtt 163789 gtttccattt tcatttttct ctaaatattt ttaaaattaa tttttgaatt tcctctttga 163849 ctcaatagtt tttcaggagc atgttgttta atttgcatat acttgttaat ttttcttggt 163909 ttctcctgtt attgatctat agctttatat cattgtgatt gagaaagata cttgatataa 163969 tgttgatctt ctgacacttg ttaagatgtt ttgtggtcta tcaattgatt tatcctagtg 164029 aatgttacat gtatacttga gaaaaatgta tattttgttg ctgttggatg aaatgttctg 164089 tataggtcta ttaactccat tggtatacgt atagttcaag tcatattttg ttattaaaaa 164149 ttttttgtct agataatagt tctgttgttg gaagtgggat attaaaatta tttactatta 164209 ttgtgctgca tttatgtctc ttttcagaac tcttaatctt tgatttatat atttaggtgc 164269 ttcagtgttg ggtgcatata tatttacaat tgttatatta tcttgatgca ctgatctttt 164329 tattataata tactgacctt ctttatctct ttttacagtt ttttttaacc taaagtttat 164389 ttggtgtgaa ataagtatag ccacccctgc tctgttttat ttgcctggaa tatcattttc 164449 catcacttca ttttcaacct gtaagtttcc tttaaggtaa ggtgagtctt ctgtaggccc 164509 atatagttgg atcttgtttg gtatgtatca tggtactgta tgccttttga ctacagaatc 164569 taatccatta aactttaaag taattattga tagatgagag gttgctactt ccattttatt 164629 gttttcaagt tgttttctag atcctacatt ttttttctta tatcttgctt tctttacttg 164689 tgatttgatt gctttttgca gggatatatt ttgaattttt taaaatattt tgtgtatcta 164749 ttataggctc atgctttgtg gttacataaa tcatcttata cctataacaa gctatgccaa 164809 gttgataaca acttaagttt gatcacttac acaaaggcta cacttttact ctcctccttc 164869 taaattttat gtttttgatg tcattcttta catcttttta taatatgcat acttaacaaa 164929 ctactgtagc tgtagttgct tttaagaatt ttgcctttta acccttatac tagagaaatc 164989 cttgatttgt tcaccatcat tacaatatta gaatgttttg gaattgaaaa atgccattaa 165049 ttttaccagt gcgttttata ctttcatatg ttttcatgtt tctattttga atccttttcc 165109 ttcagcttga agaactccct ttagcatttc ttataacgca ggtctaatgg tgagaaactc 165169 agcctttgtt actctgagaa agtctttaac atccctcatt atttaaagac aggtttgcta 165229 ggtatactat tcttgattgg caggtttttt tcttttagaa ttttgaatat attatcccac 165289 tcccttgagc tttcaaggtt aatgctgaga aatttgctga tagttttatc agggttctct 165349 tatatgtgac aattcaattc tcccttgctg ctttccatac tctaagtttt gacagttttg 165409 ttatgatgtg ccttggtgtg agtttctttt ccttttttaa attttagatt cagagggtac 165469 atgtgcagat ttgctgcaag gacatattgt gtggcgttgg gcttctgttg atcccaccac 165529 tcaagtggtg aacatagtat ctagtaggaa gttttttgtt tttttgtttt ttttttagct 165589 cttagaccct tctttttccc tttttggaag atgcagtgtc aattgtttct atatttatgt 165649 ctgtgtgtac ccaatattta gttcctactt atgtgaaaga acatgcaata tttggttttc 165709 tgtttccgtg ttaatttgca taggataata ttttccagta gtctgtccat gttgctgaaa 165769 aagacatgag tttgttcttt tttatggctt cacagtattt catgatgtat atgtacttgg 165829 tgtggattta tccggattca ttttatttgg tattctttgg gattcctgta tctggctttc 165889 tattttcttc cccagtactg ggaaattttc tgccattatt ttttgaatat gttctgtgct 165949 tgtctctctc tcctccttct gaacacctat aatgtatata ttgctctgat tgagggtgtc 166009 agtatgtctc ttaagatgtg ttcattcttt ttcattcttt ttcctttttg ctgcttagat 166069 tggatgattt ccagtgactt gtctttgagt tcattgatat tttcttctgc ttaatctcat 166129 ttgtgggtga acctttctgt caattttttc agtttagttt aatattcctc agctctaaga 166189 tttgattgat actttcatat actttctctt tgttaaagtt ctctgttttt gcatttctct 166249 ctggacctta gtgacagtct ttataatcat tattttaaat tctctattgg gtaaattaca 166309 tctcttctat tcacttgggt caatttctga acatttattt tgctctttat ttggaatata 166369 tatttcttgt ttctttagtt tccttgactc tgtgttgttt actgcacatt agataagaca 166429 gctgcctttc ccagtcttat caaacaggac ctgtgtagaa gaaaaatatc actagtccat 166489 ttgacaaaaa attttaatgt gcctctcaaa gctttgtttg tccaggccac tgtttctgtt 166549 attggtggct cccaggagat tgggatatgc catgtcctat caatactctg tgaactataa 166609 gatagaggcc agactttcaa aatgtagcca gaaaaatgtc aagtattaga tgtgtggtcc 166669 agttccttct atcctcatgt tgaaattggg tgcaggtgtt acttctccac tctctctgca 166729 tgaagccagg gagaggtact atggaaactg cctgtatttg tgttcaggcc acactttttg 166789 attctgggaa gatagctttg ggagtggggc cactgtttgt ctacatcttt gttatctgtg 166849 atctagagta agttaggaat gcaaagctcc accactccca agcttaggct gttaagaatt 166909 cagtcctttg ggtgggagct gtagaagttg tgacacttaa ttgtgaacaa actcttttca 166969 agaagaatag gtaggctata aaataataga agaaatgaat agagctatag aagttgtgac 167029 acttggtatg tgaacaaact ccttttagga aaaataggct ggggacaagc caagttctgc 167089 ttagtctacc tgagagctac tattagtctg tcttgttagc tccctgatgc aagctggagg 167149 ttaagctatg tagttgtcac tggatgagtg tgcagtaagc tgctagagaa aaaaaaaaaa 167209 aggagctgtg cattctagcc cctgttctcc actgctccca agagatatag ttcctggaag 167269 agtttgcatg cctgtttaaa accacctctt tgttctgtga tctagggaga cttgtatatg 167329 cctagtctct tctgctctta gagccaggag ttttgggata tagtatttct ggtaaatgct 167389 gtaaaagggc attttgtggg tgaacacact ccttccaggg agaattggga gagctgggat 167449 tattgctgag ttgagctgga ggaagtctca ggaagtgtta agctgctgct caggctgtta 167509 gagagctact ttttgcttgc ccctttaact ctcagatgcg ttagttagaa accagactgt 167569 caagtagccg ctaggggagt atgctgtaaa cctcttccag ggagaaccag gtagtggtat 167629 ttttgagtcc tgtctctgta ctaattctac taattcacag tgttaaagca cctgaaaaag 167689 tgcttgcaca cacatataaa actgccactg ttttcctgtg gtctaaataa acttgtgtat 167749 gtctaattct ctctaactcc cagagttggt gaattaagag ccaaactgtt gggcatctta 167809 taattggggt gccatatgta aggtcccaat cctctccaca gggagaatct gagtgttagt 167869 gattccagtt atatggtgaa gtacctggaa ggggtccatg ctcaagtatg cctcagattt 167929 gtctacccat ttgaagtgca tgtttgggtt tttattttgc ttttgatgtg tttttttttg 167989 tctttttttt tgagacagag tctcattctg ttgtaaaggc tagagtgcag tggcacaatc 168049 ttggctcact gcagcctctg cctccctggt tcaagtgatt ctcctgcctc agcctcccga 168109 gtagctgtga ctacagatgc gtaccaccat tcccagctaa tttttgtatt tttggtagag 168169 acagggtttc atcatgttat ccaggctggt ctcaaactcc tggactcaaa taatccacca 168229 gccttggcct cccaaagtgc tgggattaaa ggcatgagcc actgcgcccg gccatgcatg 168289 ttttctttct tgcctggtag gcaggaatct ctcaacttat ttctgacttt ctctcacagg 168349 gaattaattg agatgttcat tctgtgcatt tgtgagtatt gggagtgcca ggagcttcct 168409 attctgccat gttgctgaca tcagtctaag gaaaacagtt taaagaaagt tcatcaaaaa 168469 gtaacagtag acacatctgg gtgtcttaaa tatgaataca tttctttctt tctttctttc 168529 tttctttctt tctttctttc tttccttctt ttctttcttc ctttcc 168575 2 444 PRT Homo Sapiens 2 Met Ser Gly Thr Lys Leu Glu Asp Ser Pro Pro Cys Arg Asn Trp Ser 1 5 10 15 Ser Ala Ser Glu Leu Asn Glu Thr Gln Glu Pro Phe Leu Asn Pro Thr 20 25 30 Asp Tyr Asp Asp Glu Glu Phe Leu Arg Tyr Leu Trp Arg Glu Tyr Leu 35 40 45 His Pro Lys Glu Tyr Glu Trp Val Leu Ile Ala Gly Tyr Ile Ile Val 50 55 60 Phe Val Val Ala Leu Ile Gly Asn Val Leu Val Cys Val Ala Val Trp 65 70 75 80 Lys Asn His His Met Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu 85 90 95 Ser Leu Ala Asp Val Leu Val Thr Ile Thr Cys Leu Pro Ala Thr Leu 100 105 110 Val Val Asp Ile Thr Glu Thr Trp Phe Phe Gly Gln Ser Leu Cys Lys 115 120 125 Val Ile Pro Tyr Leu Gln Thr Val Ser Val Ser Val Ser Val Leu Thr 130 135 140 Leu Ser Cys Ile Ala Leu Asp Arg Trp Tyr Ala Ile Cys His Pro Leu 145 150 155 160 Met Phe Lys Ser Thr Ala Lys Arg Ala Arg Asn Ser Ile Val Ile Ile 165 170 175 Trp Ile Val Ser Cys Ile Ile Met Ile Pro Gln Ala Ile Val Met Glu 180 185 190 Cys Ser Thr Val Phe Pro Gly Leu Ala Asn Lys Thr Thr Leu Phe Thr 195 200 205 Val Cys Asp Glu Arg Trp Gly Gly Glu Ile Tyr Pro Lys Met Tyr His 210 215 220 Ile Cys Phe Phe Leu Val Thr Tyr Met Ala Pro Leu Cys Leu Met Val 225 230 235 240 Leu Ala Tyr Leu Gln Ile Phe Arg Lys Leu Trp Cys Arg Gln Ile Pro 245 250 255 Gly Thr Ser Ser Val Val Gln Arg Lys Trp Lys Pro Leu Gln Pro Val 260 265 270 Ser Gln Pro Arg Gly Pro Gly Gln Pro Thr Lys Ser Arg Met Ser Ala 275 280 285 Val Ala Ala Glu Ile Lys Gln Ile Arg Ala Arg Arg Lys Thr Ala Arg 290 295 300 Met Leu Met Val Val Leu Leu Val Phe Ala Ile Cys Tyr Leu Pro Ile 305 310 315 320 Ser Ile Leu Asn Val Leu Lys Arg Val Phe Gly Met Phe Ala His Thr 325 330 335 Glu Asp Arg Glu Thr Val Tyr Ala Trp Phe Thr Phe Ser His Trp Leu 340 345 350 Val Tyr Ala Asn Ser Ala Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser 355 360 365 Gly Lys Phe Arg Glu Glu Phe Lys Ala Ala Phe Ser Cys Cys Cys Leu 370 375 380 Gly Val His His Arg Gln Glu Asp Arg Leu Thr Arg Gly Arg Thr Ser 385 390 395 400 Thr Glu Ser Arg Lys Ser Leu Thr Thr Gln Ile Ser Asn Phe Asp Asn 405 410 415 Ile Ser Lys Leu Ser Glu Gln Val Val Leu Thr Ser Ile Ser Thr Leu 420 425 430 Pro Ala Ala Asn Gly Ala Gly Pro Leu Gln Asn Trp 435 440 3 20 DNA Artificial Sequence nucleic acid primers 3 tactactact aggccacgcg 20 4 21 DNA Artificial Sequence nucleic acid primers 4 acaccaggag gagaaagcta c 21 5 22 DNA Artificial Sequence nucleic acid primers 5 atcgcctgta aagacagcaa ag 22 6 22 DNA Artificial Sequence nucleic acid primers 6 aaagttactg agccaatgcc tc 22 7 20 DNA Artificial Sequence nucleic acid primers 7 gagaggagct tgcagcattg 20 8 22 DNA Artificial Sequence nucleic acid primers 8 aggaattcct cgtcgtcata gt 22 9 21 DNA Artificial Sequence nucleic acid primers 9 gaagaaccac cacatgagga c 21 10 22 DNA Artificial Sequence nucleic acid primers 10 atcactttgc aaagggactg tc 22 11 22 DNA Artificial Sequence nucleic acid primers 11 gtatgcaatc tgtcaccctt tg 22 12 22 DNA Artificial Sequence nucleic acid primers 12 aatgcaggag acaatccaga tg 22 13 22 DNA Artificial Sequence nucleic acid primers 13 caggcttagc caataaaacc ac 22 14 22 DNA Artificial Sequence nucleic acid primers 14 gataagccaa caccatgaga ca 22 15 22 DNA Artificial Sequence nucleic acid primers 15 acagatccct ggaacatcat ct 22 16 22 DNA Artificial Sequence nucleic acid primers 16 ctcggatctg ctttatttca gc 22 17 22 DNA Artificial Sequence nucleic acid primers 17 ccaattagca tcctcaatgt gc 22 18 22 DNA Artificial Sequence nucleic acid primers 18 gtgtgaaaag gtaaaccagg ca 22 19 22 DNA Artificial Sequence nucleic acid primers 19 ctcagtggaa aatttcgaga gg 22 20 22 DNA Artificial Sequence nucleic acid primers 20 gttgctgatt tgagtggtca ag 22 21 22 DNA Artificial Sequence nucleic acid primers 21 ctttctgagc aagttgtgct ca 22 22 22 DNA Artificial Sequence nucleic acid primers 22 taccagtttt gaagtggtcc tg 22 23 17 DNA Artificial Sequence nucleic acid primers 23 tgtaaaacga cggccag 17 24 17 DNA Artificial Sequence nucleic acid primers 24 caggaaacag ctatgac 17

Claims (6)

What is claimed is:

1. Isolated nucleic acid molecule comprising the nucleic acid having SEQ ID NO:1.

2. A DNA construct comprising the isolated nucleic acid molecule of claim 1 operatively linked to a regulatory sequence.

3. A recombinant host cell comprising the isolated nucleic acid molecule of claim 1 operatively linked to a regulatory sequence.

4. A method of diagnosing narcolepsy in an individual, comprising detecting a mutation in the gene encoding hypocretin (orexin) receptor 2, wherein the presence of the mutation in the gene is indicative of narcolepsy.

5. A pharmaceutical composition comprising a nucleic acid comprising the isolated nucleic acid molecule of claim 1.

6. A method of treating narcolepsy in an individual, comprising administering to the individual an isolated nucleic acid of claim 1 in a therapeutically effective amount.

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