UA99927C2 - Медикамент, который является активным при невропатической боли - Google Patents
Медикамент, который является активным при невропатической боли Download PDFInfo
- Publication number
- UA99927C2 UA99927C2 UAA201004709A UAA201004709A UA99927C2 UA 99927 C2 UA99927 C2 UA 99927C2 UA A201004709 A UAA201004709 A UA A201004709A UA A201004709 A UAA201004709 A UA A201004709A UA 99927 C2 UA99927 C2 UA 99927C2
- Authority
- UA
- Ukraine
- Prior art keywords
- acid
- compound
- pharmaceutical composition
- pharmaceutically acceptable
- neuropathic pain
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 12
- 208000004296 neuralgia Diseases 0.000 title abstract description 9
- 208000021722 neuropathic pain Diseases 0.000 title abstract description 9
- 150000003839 salts Chemical class 0.000 abstract description 23
- 150000001875 compounds Chemical class 0.000 abstract description 20
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 17
- 239000011707 mineral Substances 0.000 abstract description 17
- 239000002253 acid Substances 0.000 abstract description 16
- 238000004519 manufacturing process Methods 0.000 abstract description 14
- 125000004432 carbon atom Chemical group C* 0.000 abstract description 9
- 125000000217 alkyl group Chemical group 0.000 abstract description 7
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 18
- -1 hydroxy, amino Chemical group 0.000 description 15
- 235000010755 mineral Nutrition 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 12
- 108020003175 receptors Proteins 0.000 description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
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- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Данное изобретение касается соединения формулы (I), в которой R является линейной или разветвленной алкильной группой, которая содержит от 1 до 3 атомов углерода, Y является СН или N, и р является целым числом от 0 до 3, в оптимальном варианте - от 0 до 1, и ее солей, или кислых аддиционных солей с фармацевтически приемлемой органической или минеральной кислотой, или основных аддиционных солей с фармацевтически приемлемой органической или минеральной основой. Изобретение также касается способа получения соединения формулы (I) и фармацевтической композиции, которая ее включает.Изобретение также касается применения индазола для приготовления фармацевтической композиции, которая является активной при лечении от невропатической боли.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07425709 | 2007-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA99927C2 true UA99927C2 (ru) | 2012-10-25 |
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ID=39312937
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| Application Number | Title | Priority Date | Filing Date |
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| UAA201004709A UA99927C2 (ru) | 2007-11-12 | 2008-06-11 | Медикамент, который является активным при невропатической боли |
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| EP (1) | EP2207776B9 (ru) |
| JP (1) | JP5443372B2 (ru) |
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| CN (1) | CN101855220B (ru) |
| AR (1) | AR069249A1 (ru) |
| AU (1) | AU2008323026B2 (ru) |
| CA (1) | CA2702874C (ru) |
| CY (1) | CY1118131T1 (ru) |
| DK (1) | DK2207776T3 (ru) |
| EA (1) | EA019405B1 (ru) |
| ES (1) | ES2601250T3 (ru) |
| GE (1) | GEP20125526B (ru) |
| HR (1) | HRP20161497T1 (ru) |
| HU (1) | HUE031676T2 (ru) |
| IL (1) | IL205309A (ru) |
| LT (1) | LT2207776T (ru) |
| MX (1) | MX2010005267A (ru) |
| PL (1) | PL2207776T3 (ru) |
| PT (1) | PT2207776T (ru) |
| SG (1) | SG185982A1 (ru) |
| SI (1) | SI2207776T1 (ru) |
| UA (1) | UA99927C2 (ru) |
| WO (1) | WO2009062883A1 (ru) |
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| AU2013224313B2 (en) | 2012-02-21 | 2017-03-30 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
| MX351287B (es) | 2012-02-21 | 2017-10-09 | Acraf | Compuestos de 1h-indazol-3-carboxamida como inhibidores de glucogeno sintasa quinasa 3 beta. |
| CN112513011B (zh) * | 2018-07-31 | 2023-06-16 | 小野药品工业株式会社 | 苯衍生物 |
| TW202140421A (zh) | 2020-01-29 | 2021-11-01 | 日商小野藥品工業股份有限公司 | 苯衍生物的新穎晶形 |
| JP7384179B2 (ja) * | 2020-01-29 | 2023-11-21 | 小野薬品工業株式会社 | ベンゼン誘導体を含有する医薬組成物 |
| WO2022097764A1 (ko) | 2020-11-04 | 2022-05-12 | 전남대학교병원 | 프레가발린 및 티아넵틴을 포함하는 신경병성 통증 치료용 약학적 조성물 |
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| KR19990022096A (ko) * | 1995-05-31 | 1999-03-25 | 쇼다 오사무 | 모노시클릭 아미노기를 갖는 인다졸 유도체 |
| IT1291569B1 (it) | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
| AU3676100A (en) | 1999-04-09 | 2000-11-14 | Mochida Pharmaceutical Co., Ltd. | Remedies for neuropathic pain |
| ITMI20030972A1 (it) * | 2003-05-15 | 2004-11-16 | Acraf | Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende. |
| ITMI20031468A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco ativo nel dolore neuropatico |
| ATE457309T1 (de) * | 2003-12-23 | 2010-02-15 | Serodus As | Modulatoren von peripheren 5-ht-rezeptoren |
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