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UA96321C2 - Фармацевтическая композиция с активным ингредиентом аторвастатином - Google Patents

Фармацевтическая композиция с активным ингредиентом аторвастатином

Info

Publication number
UA96321C2
UA96321C2 UAA200910056A UAA200910056A UA96321C2 UA 96321 C2 UA96321 C2 UA 96321C2 UA A200910056 A UAA200910056 A UA A200910056A UA A200910056 A UAA200910056 A UA A200910056A UA 96321 C2 UA96321 C2 UA 96321C2
Authority
UA
Ukraine
Prior art keywords
weight
atorvastatin
mixture
tablets
compressed
Prior art date
Application number
UAA200910056A
Other languages
English (en)
Ukrainian (uk)
Inventor
Алёна Прокопова
Павэл Сэбэк
Анна Гановська
Михаэла Дубовська
Вацлав Томасек
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of UA96321C2 publication Critical patent/UA96321C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к области медицины и касается фармацевтической композиции, которая содержит, как активное соединение, аторвастатин, для лечения и предотвращения сердечно-сосудистых болезней, и находится в форме продолговатых покрытых таблеток, ядро которых состоит из спрессованного гранулята и содержит: аторвастатин и/или по меньшей мере одну его физиологически приемлемую соль; основание, которое является меглумином и является равномерно распределенным в ядре таблетки с помощью распыления последней на твердую смесь в процессе получения гранулята; фармацевтически приемлемый наполнитель, и дезинтегрант.
UAA200910056A 2007-03-02 2008-03-03 Фармацевтическая композиция с активным ингредиентом аторвастатином UA96321C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20070169A CZ300047B6 (cs) 2007-03-02 2007-03-02 Farmaceutická kompozice s obsahem úcinné látky atorvastatinu

Publications (1)

Publication Number Publication Date
UA96321C2 true UA96321C2 (ru) 2011-10-25

Family

ID=39590531

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200910056A UA96321C2 (ru) 2007-03-02 2008-03-03 Фармацевтическая композиция с активным ингредиентом аторвастатином

Country Status (8)

Country Link
US (1) US20110038934A1 (ru)
EP (1) EP2117534B1 (ru)
AT (1) ATE526961T1 (ru)
CZ (1) CZ300047B6 (ru)
EA (1) EA015519B1 (ru)
ES (1) ES2373492T3 (ru)
UA (1) UA96321C2 (ru)
WO (1) WO2008106901A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301299B6 (cs) * 2008-11-24 2010-01-06 Zentiva, A.S. Pevná farmaceutická kompozice s úcinnými látkami atorvastatinem a telmisartanem
HUP1000299A2 (hu) 2010-06-08 2012-02-28 Nanoform Cardiovascular Therapeutics Ltd Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra
CN105168162A (zh) * 2015-09-06 2015-12-23 合肥华方医药科技有限公司 一种阿托伐他汀钙口腔速崩片及其制备方法
IL269884B2 (en) 2017-04-18 2023-09-01 Gemphire Therapeutics Inc Gamkaban its accepted pharmaceutical salts, their compositions and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2226636A1 (en) * 1998-03-18 1999-09-18 Keith Cornies Stacking pharmacapsule
GB0111077D0 (en) * 2001-05-04 2001-06-27 Biochemie Gmbh Organic compounds
ITMI20010538U1 (it) * 2001-10-03 2003-04-03 Pillot Massimo Contenitore portatile particolarmente studiato per confezioni tipo "blister",contenenti pastiglie di farmaci, prodotti dolciari, e altri pro
OA12777A (en) * 2002-02-14 2006-07-06 Ranbaxy Lab Ltd Formulations of atorvastatin stabilized with alkali metal additions.
WO2004082665A1 (ja) * 2003-03-17 2004-09-30 Takeda Pharmaceutical Company Limited 放出制御組成物
CZ2003987A3 (cs) * 2003-04-08 2004-11-10 Zentiva A. S. Způsob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbanioyl-2-(4- fluorfenyl)-5-isopropylpyrrol-l-yl]-3,5- dihydroxyheptanové kyseliny (atorvastatinu) vhodný pro průmyslovou výrobu a zařízení k jeho provádění
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
ES2298763T3 (es) * 2003-08-05 2008-05-16 Zentiva, A.S. Metodos para la estabilizacion de la atorvastatina.
RU2343905C2 (ru) * 2003-10-10 2009-01-20 Лайфсайкл Фарма А/С Твердые дозированные формы, включающие фибрат и статин
US20070014846A1 (en) * 2003-10-10 2007-01-18 Lifecycle Pharma A/S Pharmaceutical compositions comprising fenofibrate and atorvastatin
WO2006006021A2 (en) * 2004-06-28 2006-01-19 Glenmark Pharmaceuticals Limited Stabilized pharmaceutical compositions of preferably a statin
EP1808162A1 (en) * 2005-11-21 2007-07-18 Teva Pharmaceutical Industries Ltd. Atorvastatin pharmaceutical formulation
EP1810667A1 (en) * 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
SI22255A (sl) * 2006-04-14 2007-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Novi polimorfi statinovih soli in njihova uporabav farmacevtskih formulacijah

Also Published As

Publication number Publication date
US20110038934A1 (en) 2011-02-17
EP2117534B1 (en) 2011-10-05
ES2373492T3 (es) 2012-02-06
CZ300047B6 (cs) 2009-01-21
EA015519B1 (ru) 2011-08-30
WO2008106901A1 (en) 2008-09-12
ATE526961T1 (de) 2011-10-15
CZ2007169A3 (cs) 2008-09-10
EP2117534A1 (en) 2009-11-18
WO2008106901A8 (en) 2010-04-01
EA200901191A1 (ru) 2010-02-26

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