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UA96304C2 - 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS - Google Patents

2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS

Info

Publication number
UA96304C2
UA96304C2 UAA200902219A UAA200902219A UA96304C2 UA 96304 C2 UA96304 C2 UA 96304C2 UA A200902219 A UAA200902219 A UA A200902219A UA A200902219 A UAA200902219 A UA A200902219A UA 96304 C2 UA96304 C2 UA 96304C2
Authority
UA
Ukraine
Prior art keywords
pyrazo
pyrimido
pyrido
methylmorpholine
pyrimidine derivatives
Prior art date
Application number
UAA200902219A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Хедер Мери Эллен Дагган
Фредерик Жорж Мари Леру
Карине Малагу
Нилл Моррисон Барр Мартин
Кейт Аллан Минер
Грейм Камерон Марри Смит
Original Assignee
Кудос Фармасьютикалз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кудос Фармасьютикалз Лимитед filed Critical Кудос Фармасьютикалз Лимитед
Publication of UA96304C2 publication Critical patent/UA96304C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There is provided a compound of Formula (I), or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula (1), and the use of a compound of Formula (1) as a medicament and in the treatment of cancer.
UAA200902219A 2006-08-23 2007-08-21 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS UA96304C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82331106P 2006-08-23 2006-08-23

Publications (1)

Publication Number Publication Date
UA96304C2 true UA96304C2 (en) 2011-10-25

Family

ID=41175600

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200902219A UA96304C2 (en) 2006-08-23 2007-08-21 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS

Country Status (3)

Country Link
CN (1) CN101558067B (en)
UA (1) UA96304C2 (en)
ZA (1) ZA200900992B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887895B (en) * 2011-07-22 2016-08-24 山东轩竹医药科技有限公司 Pyridopyrimidine class mTOR inhibitors
CN103588792B (en) * 2013-03-04 2016-03-23 中国科学院上海药物研究所 Pyridopyrimidine or pyrimidopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof
CN104557913B (en) * 2013-10-28 2017-02-08 上海汇伦生命科技有限公司 Pyridopyrimidine compounds as well as preparation method and application thereof
CN103908452A (en) * 2014-02-18 2014-07-09 广州金域医学检验中心有限公司 Composite drug and medicinal preparation for inhibiting lung cancer cell metastasis and detection method for lung cancer cell metastasis
CN106008559B (en) * 2015-03-25 2020-10-16 中国科学院上海药物研究所 Synthetic technology of substituted pyridopyrimidines
WO2019085996A1 (en) * 2017-11-06 2019-05-09 南京明德新药研发股份有限公司 Pyridopyrimidine compounds acting as mtorc 1/2 double-kinase inhibitors
CN110407833B (en) * 2018-04-28 2021-03-09 海创药业股份有限公司 Deuterated Vissturtib compound and application thereof
CN113286594B (en) * 2019-01-18 2023-12-15 南京明德新药研发有限公司 Application of pyridopyrimidine compounds in the preparation of drugs for the treatment of nasopharyngeal cancer
JP7307817B2 (en) * 2019-05-06 2023-07-12 メッドシャイン ディスカバリー インコーポレイテッド Salt form, crystal form of mTORC1/2 dual kinase activity inhibitor and method for producing the same
CN111892529A (en) * 2020-08-19 2020-11-06 南通大学 A kind of 6-chloro-5-hydroxyisoindol-1-one and its synthesis method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990117A (en) * 1998-04-15 1999-11-23 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives
EP1277738B1 (en) * 2000-04-27 2011-03-30 Astellas Pharma Inc. Condensed heteroaryl derivatives
CA2628920C (en) * 2005-11-22 2015-12-29 Kudos Pharmaceuticals Limited Pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors

Also Published As

Publication number Publication date
CN101558067B (en) 2014-05-28
CN101558067A (en) 2009-10-14
ZA200900992B (en) 2010-07-28

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