UA94055C2 - Substituted benzimidazoles and methods of preparation - Google Patents
Substituted benzimidazoles and methods of preparationInfo
- Publication number
- UA94055C2 UA94055C2 UAA200802593A UAA200802593A UA94055C2 UA 94055 C2 UA94055 C2 UA 94055C2 UA A200802593 A UAA200802593 A UA A200802593A UA A200802593 A UAA200802593 A UA A200802593A UA 94055 C2 UA94055 C2 UA 94055C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methods
- compositions
- kinase
- compounds
- preparation
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 2
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000027426 receptor tyrosine kinases Human genes 0.000 abstract 2
- 108091008598 receptor tyrosine kinases Proteins 0.000 abstract 2
- 208000005623 Carcinogenesis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000036952 cancer formation Effects 0.000 abstract 1
- 231100000504 carcinogenesis Toxicity 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
New substituted benzimidazole compounds of formula (I), compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase or receptor tyrosine kinase mediated disorder, such as cancer.(I),
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71253905P | 2005-08-30 | 2005-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA94055C2 true UA94055C2 (en) | 2011-04-11 |
Family
ID=39956007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200802593A UA94055C2 (en) | 2005-08-30 | 2006-08-30 | Substituted benzimidazoles and methods of preparation |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN101253168B (en) |
| ES (1) | ES2360608T3 (en) |
| UA (1) | UA94055C2 (en) |
| ZA (1) | ZA200800506B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102336740B (en) * | 2010-07-27 | 2013-07-24 | 中国科学院上海药物研究所 | Novel imidazole compound and its application |
| MX2013005668A (en) * | 2010-11-19 | 2013-11-04 | Glaxosmithkline Ip No 2 Ltd | TREATMENT METHOD WITH BRAF INHIBITOR. |
| TW201722957A (en) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產（第二）有限公司 | Chemical compounds |
| CA3040803A1 (en) * | 2016-10-27 | 2018-05-03 | Damian Pharma Ag | Aldosterone synthase inhibitor |
| MX390348B (en) * | 2016-12-15 | 2025-03-20 | Ariad Pharma Inc | BENZIMIDAZOLE COMPOUNDS AS C-KIT INHIBITORS |
| CN115791738B (en) * | 2022-12-23 | 2025-11-21 | 山西农业大学 | Application of choline type rare earth fluorescent probe in detection of nitro compound in ionic liquid and nitro compound in water |
-
2006
- 2006-08-30 ES ES06790127T patent/ES2360608T3/en active Active
- 2006-08-30 UA UAA200802593A patent/UA94055C2/en unknown
- 2006-08-30 CN CN200680031748.1A patent/CN101253168B/en not_active Expired - Fee Related
-
2008
- 2008-01-17 ZA ZA200800506A patent/ZA200800506B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2360608T3 (en) | 2011-06-07 |
| CN101253168B (en) | 2012-12-12 |
| ZA200800506B (en) | 2009-11-25 |
| CN101253168A (en) | 2008-08-27 |
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