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UA93377C2 - Макроциклические ингибиторы вируса гепатита c - Google Patents

Макроциклические ингибиторы вируса гепатита c

Info

Publication number
UA93377C2
UA93377C2 UAA200800492A UAA200800492A UA93377C2 UA 93377 C2 UA93377 C2 UA 93377C2 UA A200800492 A UAA200800492 A UA A200800492A UA A200800492 A UAA200800492 A UA A200800492A UA 93377 C2 UA93377 C2 UA 93377C2
Authority
UA
Ukraine
Prior art keywords
calkyl
calkylenecarbocyclyl
ris
hydrogen
calkyleneheterocyclyl
Prior art date
Application number
UAA200800492A
Other languages
English (en)
Ukrainian (uk)
Inventor
Пьер Жан-Мари Бернар Рабуассон
Кок Герман Аугустинус де
Лили Xy
Кеннет Алан Симмен
Карин Шарлотта Линдквист
Матс Стефан Линдстром
Анна Карин Гертруд Линнеа Белфраге
Хорст Юрген Велинг
Карл Магнус Нилссон
Бенгт Бертил Самуэльссон
Эса Анника Кристина Розенквист
Свен Кристер Сальберг
Ханс Кристиан Валльберг
Пиа Сесилия Канберг
Бьорн Олоф Классон
Original Assignee
Тиботек Фармасьютикелз Лтд.
Медивир Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тиботек Фармасьютикелз Лтд., Медивир Аб filed Critical Тиботек Фармасьютикелз Лтд.
Publication of UA93377C2 publication Critical patent/UA93377C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Соединения формулы (І)и их N-оксиды, соли и стереоизомеры, в которой значения радикалов представлены в описании.Заявленные соединения применяют при лечении или профилактике флавивирусных инфекций, таких как HCV.
UAA200800492A 2005-07-29 2006-07-28 Макроциклические ингибиторы вируса гепатита c UA93377C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05107057 2005-07-29

Publications (1)

Publication Number Publication Date
UA93377C2 true UA93377C2 (ru) 2011-02-10

Family

ID=35695633

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200800492A UA93377C2 (ru) 2005-07-29 2006-07-28 Макроциклические ингибиторы вируса гепатита c

Country Status (3)

Country Link
CN (1) CN101233131B (ru)
UA (1) UA93377C2 (ru)
ZA (1) ZA200800859B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103387509B (zh) * 2012-05-11 2016-06-08 重庆博腾制药科技股份有限公司 一种hcv蛋白酶抑制剂中间体的制备方法
CN112358450A (zh) * 2020-11-19 2021-02-12 南京艾康生物科技有限公司 一种4-(苄氧基)-2-甲基-1H-苯并[d]咪唑-6-羧酸的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867185B2 (en) * 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US20050075279A1 (en) * 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
AU2004274051A1 (en) * 2003-09-22 2005-03-31 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus

Also Published As

Publication number Publication date
CN101233131A (zh) 2008-07-30
CN101233131B (zh) 2011-06-08
ZA200800859B (en) 2009-06-24

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