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UA93047C2 - ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-d]АЗЕПИНА КАК АНТАГОНИСТЫ H3-РЕЦЕПТОРОВ ГИСТАМИНА - Google Patents

ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-d]АЗЕПИНА КАК АНТАГОНИСТЫ H3-РЕЦЕПТОРОВ ГИСТАМИНА

Info

Publication number
UA93047C2
UA93047C2 UAA200800190A UAA200800190A UA93047C2 UA 93047 C2 UA93047 C2 UA 93047C2 UA A200800190 A UAA200800190 A UA A200800190A UA A200800190 A UAA200800190 A UA A200800190A UA 93047 C2 UA93047 C2 UA 93047C2
Authority
UA
Ukraine
Prior art keywords
antagonists
pyrazolo
histamine
azepine derivatives
derivatives
Prior art date
Application number
UAA200800190A
Other languages
English (en)
Ukrainian (uk)
Inventor
Марк Джеймс Бемфорд
Девид Меттью Уилсон
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of UA93047C2 publication Critical patent/UA93047C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Данное изобретение касается пиразольных производных формулы (И), которые проявляют фармакологическую активность как Н3-антагонисты, способов их получения, композиций, которые их содержат, и их применения при лечении неврологических и психических расстройств.(И)
UAA200800190A 2005-07-06 2006-07-04 ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-d]АЗЕПИНА КАК АНТАГОНИСТЫ H3-РЕЦЕПТОРОВ ГИСТАМИНА UA93047C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds

Publications (1)

Publication Number Publication Date
UA93047C2 true UA93047C2 (ru) 2011-01-10

Family

ID=34856781

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200800190A UA93047C2 (ru) 2005-07-06 2006-07-04 ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-d]АЗЕПИНА КАК АНТАГОНИСТЫ H3-РЕЦЕПТОРОВ ГИСТАМИНА

Country Status (27)

Country Link
US (1) US7888347B2 (ru)
EP (1) EP1899350B1 (ru)
JP (1) JP5145218B2 (ru)
KR (1) KR20080037651A (ru)
CN (1) CN101258154B (ru)
AT (1) ATE467636T1 (ru)
AU (1) AU2006286897A1 (ru)
BR (1) BRPI0612719A2 (ru)
CA (1) CA2614232A1 (ru)
CR (1) CR9622A (ru)
CY (1) CY1110711T1 (ru)
DE (1) DE602006014273D1 (ru)
DK (1) DK1899350T3 (ru)
EA (1) EA013600B1 (ru)
ES (1) ES2345841T3 (ru)
GB (1) GB0513886D0 (ru)
HR (1) HRP20100401T1 (ru)
IL (1) IL188184A0 (ru)
MA (1) MA29623B1 (ru)
MX (1) MX2008000383A (ru)
NO (1) NO20080563L (ru)
PL (1) PL1899350T3 (ru)
PT (1) PT1899350E (ru)
SI (1) SI1899350T1 (ru)
UA (1) UA93047C2 (ru)
WO (1) WO2007025596A1 (ru)
ZA (1) ZA200710798B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
SG173312A1 (en) 2006-06-23 2011-08-29 Abbott Lab Cyclopropyl amine derivatives as histamin h3 receptor modulators
KR20100059919A (ko) 2007-09-24 2010-06-04 코멘티스, 인코포레이티드 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
CN102952139B (zh) * 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9910887B2 (en) * 2013-04-25 2018-03-06 Facebook, Inc. Variable search query vertical access
SG10202011665SA (en) * 2016-05-25 2020-12-30 Akarna Therapeutics Ltd Fused bicyclic compounds for the treatment of disease

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002524399A (ja) * 1998-09-09 2002-08-06 石原産業株式会社 除草剤として有用な縮合ベンゼン誘導体
WO2000063208A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Substituted imidazoles, their preparation and use
JP2001220390A (ja) 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
EP1513842B1 (en) 2002-06-06 2007-03-07 Novo Nordisk A/S Substituted hexahydropyrrolo (1,2-a)pyrazines, octahydropyrido(1,2-a)pyrazines and decahydropyrazino(1,2-a)azepines
US6770597B2 (en) 2002-07-17 2004-08-03 Ishihara Sangyo Kaisha, Ltd. Benzohydrazide derivatives as herbicides and desiccant compositions containing them
US20060135508A1 (en) 2002-07-25 2006-06-22 Manuela Villa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US20060089347A1 (en) * 2002-08-20 2006-04-27 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
GB0224083D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
EP2186516B1 (en) 2002-12-20 2013-01-16 Glaxo Group Limited Novel benzazepine derivative
EA200801812A1 (ru) * 2003-09-17 2009-06-30 Янссен Фармацевтика Н.В. Сопряженные гетероциклические соединения
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
EP1756094A1 (en) 2004-06-18 2007-02-28 Glaxo Group Limited 3-cycloalkylbenzazepines as histamine h3 antagonists
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
EP1833796A1 (en) 2004-12-07 2007-09-19 Glaxo Group Limited Indenyl derivatives and use thereof for the treatment of neurological disorders
ATE420091T1 (de) 2005-03-14 2009-01-15 Glaxo Group Ltd Kondensierte thiazolderivate mit affinität für den histamin-h3-rezeptor

Also Published As

Publication number Publication date
CR9622A (es) 2008-04-10
CA2614232A1 (en) 2007-03-08
MX2008000383A (es) 2008-03-07
AU2006286897A1 (en) 2007-03-08
IL188184A0 (en) 2008-03-20
CY1110711T1 (el) 2015-06-10
JP2009500366A (ja) 2009-01-08
SI1899350T1 (sl) 2010-09-30
MA29623B1 (fr) 2008-07-01
PT1899350E (pt) 2010-07-21
DE602006014273D1 (de) 2010-06-24
KR20080037651A (ko) 2008-04-30
NO20080563L (no) 2008-02-01
CN101258154B (zh) 2011-01-19
ES2345841T3 (es) 2010-10-04
HRP20100401T1 (hr) 2010-09-30
ATE467636T1 (de) 2010-05-15
EA013600B1 (ru) 2010-06-30
CN101258154A (zh) 2008-09-03
BRPI0612719A2 (pt) 2010-11-30
JP5145218B2 (ja) 2013-02-13
DK1899350T3 (da) 2010-09-06
EP1899350A1 (en) 2008-03-19
EP1899350B1 (en) 2010-05-12
EA200800264A1 (ru) 2008-06-30
ZA200710798B (en) 2008-11-26
US7888347B2 (en) 2011-02-15
US20080176832A1 (en) 2008-07-24
PL1899350T3 (pl) 2010-10-29
GB0513886D0 (en) 2005-08-10
WO2007025596A1 (en) 2007-03-08

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