UA93922C2 - Process for production of peptides, specifically recognizing the cells of particular type, meant for therapeutic goals - Google Patents
Process for production of peptides, specifically recognizing the cells of particular type, meant for therapeutic goalsInfo
- Publication number
- UA93922C2 UA93922C2 UAA200902499A UAA200902499A UA93922C2 UA 93922 C2 UA93922 C2 UA 93922C2 UA A200902499 A UAA200902499 A UA A200902499A UA A200902499 A UAA200902499 A UA A200902499A UA 93922 C2 UA93922 C2 UA 93922C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cells
- peptides
- particular type
- production
- therapy
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 11
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 11
- 238000000034 method Methods 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 11
- 238000002560 therapeutic procedure Methods 0.000 abstract 4
- 238000012790 confirmation Methods 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 208000037273 Pathologic Processes Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000013467 fragmentation Methods 0.000 abstract 1
- 238000006062 fragmentation reaction Methods 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 230000009054 pathological process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 241001515965 unidentified phage Species 0.000 abstract 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention relates to genetic engineering, in particular to the processes for production of peptides, specifically recognizing the cells of particular type, which can be used in diagnostics, therapy, and pharmaceutics. According to the invention, the large amount of libraries of random peptides are constructed on the basis of oligonucleotide fragments, coding them, by means of fragmentation of total RNA of cells of particular type and cells of the other types, which can be involved in pathological process and influence on its diagnostics and therapy. The mentioned fragments are cloned in right orientation into the vector on the basis of bacteriophage. After that library screening is realized with using of combination of cells of particular type and cells of the other types in several stages for production of groups of peptides, specifically recognizing the cells of selected type as part of vector. From the produced peptides the individual peptides are isolated and tested as part of phage particles with using of combined tests for confirmation of theirs specificity towards the cells of particular type. For production of pure peptides the matrixes are designed on the basis of amino acid sequences of peptides as part of phage particles, from whish the sequences of new peptides are read and they are chemically synthesized, with further confirmation of specific recognition of cells of selected type. The conducting of such method allows to obtain peptides, recognizing cells of particular type with high level of specificity and selectiveness, which can be used for delivery of drugs to the place of theirs direct action for the purpose of prevention and/or therapy, connected with disorder of function of cells of particular type, for example, vascular smooth muscle cells, and also for immediate using of produced peptides as a dosage form in therapy, and also for diagnostics of disorder of function of cells of particular type and to prognosticate theirs treatment.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200902499A UA93922C2 (en) | 2009-03-20 | 2009-03-20 | Process for production of peptides, specifically recognizing the cells of particular type, meant for therapeutic goals |
| RU2011140269/10A RU2528739C2 (en) | 2009-03-20 | 2009-03-27 | Method of producing peptides specifically identifying certain types of cells and intended for therapeutic purposes |
| PCT/UA2009/000011 WO2010107405A1 (en) | 2009-03-20 | 2009-03-27 | Method for producing peptides which specifically recognize cells of particular types and can be used for therapeutic purposes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200902499A UA93922C2 (en) | 2009-03-20 | 2009-03-20 | Process for production of peptides, specifically recognizing the cells of particular type, meant for therapeutic goals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA93922C2 true UA93922C2 (en) | 2011-03-25 |
Family
ID=42739879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200902499A UA93922C2 (en) | 2009-03-20 | 2009-03-20 | Process for production of peptides, specifically recognizing the cells of particular type, meant for therapeutic goals |
Country Status (3)
| Country | Link |
|---|---|
| RU (1) | RU2528739C2 (en) |
| UA (1) | UA93922C2 (en) |
| WO (1) | WO2010107405A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2572710C1 (en) * | 2014-08-13 | 2016-01-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарёва" | Compound of nibentane and amino acid possessing antiarhythmic activity and method for producing it |
| DK3209819T3 (en) * | 2014-10-22 | 2024-05-21 | 48Hour Discovery Inc | GENETIC ENCODING OF CHEMICAL POST-TRANSLATIONAL MODIFICATION FOR PHAGE-DISPLAYED LIBRARIES |
| EP3827116A4 (en) | 2018-07-23 | 2022-05-11 | The Governors of the University of Alberta | GENETICALLY ENCODED BICYCLIC PEPTIDE LIBRARIES |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| DE60331422D1 (en) * | 2002-01-22 | 2010-04-08 | Evrogen Ip | FLUORESCENT PROTEIN FROM AEQUOREA COERULESCENS AND ITS USES |
| RU2263146C2 (en) * | 2003-07-10 | 2005-10-27 | Михаил Викторович Разуменко | Method for preparing bacteriophages binding specifically with target-cells and designated for therapeutic aims |
| UA66110A (en) * | 2003-07-28 | 2004-04-15 | Mykhailo Viktorovych Razumenko | A method for the preparation of specific peptides for therapeutic purposes |
-
2009
- 2009-03-20 UA UAA200902499A patent/UA93922C2/en unknown
- 2009-03-27 RU RU2011140269/10A patent/RU2528739C2/en not_active IP Right Cessation
- 2009-03-27 WO PCT/UA2009/000011 patent/WO2010107405A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011140269A (en) | 2013-04-27 |
| RU2528739C2 (en) | 2014-09-20 |
| WO2010107405A1 (en) | 2010-09-23 |
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