UA91693C2 - Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to madulation of the dopamine d3 receptor - Google Patents

Abstract

The present invention relates to aromatic compounds of the formula (I), wherein Ar is phenyl or an aromatic 5-or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Rand wherein Ar may also carry 1 or 2 radicals R; X is N or CH; Y is O, S, -CH=N-, -CH=CH- or -N=CH-; A is CHO or S; E is CRRor NR; Ris C-C-alkyl, C-C-cycloalkyl, C-C-cycloalkylmethyl, C-C-alkenyl, fluorinated C-C-alkyl, fluorinated C-C-cycloalkyl, fluorinated C-C-cycloalkylmethyl, fluorinated C-C-alkenyl, formyl or C-C-alkylcarbonyl; Ris H, C-C-alkyl, C-C-cycloalkyl, C-C-alkenyl, fluorinated C-C-alkyl, fluorinated C-C-cycloalkyl, or Rand Rtogether arc (CH)with n being 2 or 3, or Rand Rtogether are (CH)with n being 2 or 3; Rand Rare independently of each other H, CH, CHF, CHFor CF; Ris H or C-C-alkyl; R, Rindependently of each other are selected from H, C-C-alkyl and fluorinated C-C-alkyl; and the physiologically tolerated acid addition sails thereof. The invention also relates to the use of a compound of the formula T or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine Dreceptor ligand.