UA90690C2 - Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation (variants) - Google Patents
Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation (variants)Info
- Publication number
- UA90690C2 UA90690C2 UAA200704725A UAA200704725A UA90690C2 UA 90690 C2 UA90690 C2 UA 90690C2 UA A200704725 A UAA200704725 A UA A200704725A UA A200704725 A UAA200704725 A UA A200704725A UA 90690 C2 UA90690 C2 UA 90690C2
- Authority
- UA
- Ukraine
- Prior art keywords
- substituted
- unsubstituted
- inhibitors
- dipeptidyl peptidase
- variants
- Prior art date
Links
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 2
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 2
- -1 SOH Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
, (I)The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: (I) wherein Y is -S(O)–CH-, CUF, or –CF; m is 0, 1, or 2; X is a bond, C-Calkyl (e.g., -CH-), or -C(=O)-; the dotted line [----] in the carbocyclic ring represents an optional double bond; R is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted heteroarylalkyl, CN, -COOR, CONRR, -OR, NRRor NRCOR; Ris hydrogen, cyano, COOM, or an isostere of a carboxylic acid (such as SOH, CONOH, B(OH), PORR, SONRR, tetrazole, -COOR, -CONRY, NROR, or -COOCOR).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61810204P | 2004-10-12 | 2004-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA90690C2 true UA90690C2 (en) | 2010-05-25 |
Family
ID=38938220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200704725A UA90690C2 (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation (variants) |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101087757B (en) |
| UA (1) | UA90690C2 (en) |
| ZA (1) | ZA200703661B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104072381B (en) * | 2013-03-26 | 2017-04-12 | 安徽贝克联合制药有限公司 | Preparation method for optically pure aminoalcohol hydrochloride |
| CN103804266B (en) * | 2014-02-21 | 2016-06-08 | 张家港威胜生物医药有限公司 | A kind of synthetic method of vildagliptin intermediate |
| CN104030958B (en) * | 2014-06-06 | 2016-06-29 | 河北科技大学 | A kind of (S)-1-(2-chloracetyl) synthetic method of pyrrolidine-2-formonitrile HCN |
| CN114516828A (en) * | 2020-11-19 | 2022-05-20 | 江苏威奇达药业有限公司 | Extraction process for improving extraction rate of negative nitrogen |
| CN117756677B (en) * | 2023-12-21 | 2025-09-30 | 上海馨远医药科技有限公司 | A preparation method of chiral trans-N-BOC-1-aminocyclopentane-3-carboxylic acid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9802538D0 (en) * | 1998-07-13 | 1998-07-13 | Astra Ab | New pharmaceutically active compounds |
| US20020052370A1 (en) * | 2000-07-06 | 2002-05-02 | Barber Christopher Gordon | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
| TWI290919B (en) * | 2000-10-06 | 2007-12-11 | Tanabe Seiyaku Co | Nitrogen-containing five-membered ring compound, a pharmacologically permissible salt thereof and the method for producing the same |
-
2005
- 2005-07-26 UA UAA200704725A patent/UA90690C2/en unknown
- 2005-07-26 CN CN2005800374009A patent/CN101087757B/en not_active Expired - Fee Related
-
2007
- 2007-05-07 ZA ZA200703661A patent/ZA200703661B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101087757A (en) | 2007-12-12 |
| ZA200703661B (en) | 2008-10-29 |
| CN101087757B (en) | 2013-01-02 |
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