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UA89200C2 - S-TRIAZOLYL-α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE - Google Patents

S-TRIAZOLYL-α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE

Info

Publication number
UA89200C2
UA89200C2 UAA200702491A UAA200702491A UA89200C2 UA 89200 C2 UA89200 C2 UA 89200C2 UA A200702491 A UAA200702491 A UA A200702491A UA A200702491 A UAA200702491 A UA A200702491A UA 89200 C2 UA89200 C2 UA 89200C2
Authority
UA
Ukraine
Prior art keywords
triazolyl
reverse transcriptase
mercaptoacetanildes
inhibitors
hiv reverse
Prior art date
Application number
UAA200702491A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Жан-Люк Жирарде
Юнг-Хио Кох
Ла Роса Марта Де
Эсмир Ганик
Чжи Хонг
Стенли Ленг
Хонг Ву Ким
Original Assignee
Ардеа Биосаенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ардеа Биосаенсиз, Инк. filed Critical Ардеа Биосаенсиз, Инк.
Publication of UA89200C2 publication Critical patent/UA89200C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is COH, CONR, SOH, or SONR. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
UAA200702491A 2004-08-25 2005-08-25 S-TRIAZOLYL-α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE UA89200C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60421904P 2004-08-25 2004-08-25

Publications (1)

Publication Number Publication Date
UA89200C2 true UA89200C2 (en) 2010-01-11

Family

ID=40908676

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200702491A UA89200C2 (en) 2004-08-25 2005-08-25 S-TRIAZOLYL-α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE
UAA200909742A UA97139C2 (en) 2004-08-25 2005-08-25 Normal;heading 1;heading 2;heading 3;2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID AND METHYL ESTER

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA200909742A UA97139C2 (en) 2004-08-25 2005-08-25 Normal;heading 1;heading 2;heading 3;2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID AND METHYL ESTER

Country Status (3)

Country Link
KR (1) KR100940058B1 (en)
UA (2) UA89200C2 (en)
ZA (1) ZA200702390B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642277B2 (en) * 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
KR20090111357A (en) 2009-10-26
ZA200702390B (en) 2008-10-29
UA97139C2 (en) 2012-01-10
KR100940058B1 (en) 2010-02-04

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