UA88294C2 - Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation - Google Patents
Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferationInfo
- Publication number
- UA88294C2 UA88294C2 UAA200610138A UAA200610138A UA88294C2 UA 88294 C2 UA88294 C2 UA 88294C2 UA A200610138 A UAA200610138 A UA A200610138A UA A200610138 A UAA200610138 A UA A200610138A UA 88294 C2 UA88294 C2 UA 88294C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cancer
- antibodies
- methods
- cancer cell
- cell proliferation
- Prior art date
Links
- 230000009702 cancer cell proliferation Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 5
- 201000011510 cancer Diseases 0.000 abstract 4
- 230000003527 anti-angiogenesis Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 230000005880 cancer cell killing Effects 0.000 abstract 1
- 239000012830 cancer therapeutic Substances 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention provides methods for direct killing of cancer cells using anti- α5β1 antibodies. Generally, the method comprises contacting a cancer cell that expresses α5β1 on its surface with an anti-α5β1 antibody, and thereby inducing the death of the cancer cell. The methods of the invention may be employed at an early stage of cancer development in a patient to prevent tumor establishment. In addition, the methods may be used to treat previously formed tumors especially in cancer that have not proven susceptible to anti-angiogenesis therapy. The methods may be employed as a combination therapy of anti-α5β1 antibodies together with cancer chemotherapeutic agents or other molecular-based cancer therapeutic agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55642104P | 2004-03-24 | 2004-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA88294C2 true UA88294C2 (en) | 2009-10-12 |
Family
ID=37879292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200610138A UA88294C2 (en) | 2004-03-24 | 2005-03-24 | Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1933851B (en) |
| UA (1) | UA88294C2 (en) |
| ZA (1) | ZA200607849B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2596361A1 (en) * | 2010-07-19 | 2013-05-29 | F.Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
| US8946159B2 (en) * | 2011-12-22 | 2015-02-03 | California Northstate College Of Pharmacy, Llc | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
| CA3121288A1 (en) * | 2018-11-29 | 2020-06-04 | Harbour Biomed Therapeutics Limited | Anti-pd-l1 antibody preparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
-
2005
- 2005-03-24 UA UAA200610138A patent/UA88294C2/en unknown
- 2005-03-24 CN CN2005800094629A patent/CN1933851B/en not_active Expired - Fee Related
-
2006
- 2006-09-19 ZA ZA200607849A patent/ZA200607849B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200607849B (en) | 2007-12-27 |
| CN1933851B (en) | 2011-09-14 |
| CN1933851A (en) | 2007-03-21 |
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