UA88894C2 - Stable pharmaceutical solution formulation for pressurized metered dose inhalers - Google Patents
Stable pharmaceutical solution formulation for pressurized metered dose inhalersInfo
- Publication number
- UA88894C2 UA88894C2 UAA200608865A UAA200608865A UA88894C2 UA 88894 C2 UA88894 C2 UA 88894C2 UA A200608865 A UAA200608865 A UA A200608865A UA A200608865 A UAA200608865 A UA A200608865A UA 88894 C2 UA88894 C2 UA 88894C2
- Authority
- UA
- Ukraine
- Prior art keywords
- metered dose
- solution formulation
- dose inhalers
- stable pharmaceutical
- pharmaceutical solution
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003186 pharmaceutical solution Substances 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000000443 aerosol Substances 0.000 abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000005828 hydrofluoroalkanes Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-1[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (ТА 2005), as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid and optionally by the use of a suitable can having part or all of its internal metallic surfaces lined with an inert organic coating.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54779804P | 2004-02-27 | 2004-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA88894C2 true UA88894C2 (en) | 2009-12-10 |
Family
ID=37779269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200608865A UA88894C2 (en) | 2004-02-27 | 2005-02-25 | Stable pharmaceutical solution formulation for pressurized metered dose inhalers |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN100457087C (en) |
| UA (1) | UA88894C2 (en) |
| ZA (1) | ZA200606577B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3089735T1 (en) * | 2013-12-30 | 2018-10-30 | Chiesi Farmaceutici S.P.A. | Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA939195B (en) * | 1992-12-09 | 1995-06-08 | Boehringer Ingelheim Pharma | Stabilized medicinal aerosol solution formulations |
| DE19847969A1 (en) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Stable liquid formulation of formoterol in solution or suspension medium, used after dilution for treatment of asthma by inhalation |
| DZ2947A1 (en) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Pressure metered dose inhaler. |
| HU230804B1 (en) * | 2000-05-22 | 2018-06-28 | Chiesi Farmaceutici S.P.A | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
| HUE049426T2 (en) * | 2002-03-01 | 2020-09-28 | Chiesi Farm Spa | Formoterol superfine formulation |
-
2005
- 2005-02-25 UA UAA200608865A patent/UA88894C2/en unknown
- 2005-02-25 CN CNB2005800060603A patent/CN100457087C/en not_active Expired - Fee Related
-
2006
- 2006-08-07 ZA ZA200606577A patent/ZA200606577B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200606577B (en) | 2009-04-29 |
| CN100457087C (en) | 2009-02-04 |
| CN1921835A (en) | 2007-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TNSN06250A1 (en) | Stable pharmaceutical solution formulations for pressurized metered dose inhalers | |
| MXPA02011414A (en) | Stable pharmaceutical solution formulations for pressurised metered dose inhalers. | |
| WO2007123945A3 (en) | Mechanical single dose intrapulmonary drug delivery devices | |
| ATE308317T1 (en) | PREPARATIONS CONTAINING AN ANTICHOLINERGIC ACTIVE INGREDIENT FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE | |
| TW200735870A (en) | Pharmaceutical formulations comprising a long-acting beta2-agonist for administration by nebulisation | |
| EA200401019A1 (en) | DOSED MEDICAL FORM FOR ORAL APPLICATION CONTAINING PDE 4 INHIBITOR AS AN ACTIVE SUBSTANCE AND POLYVINYLPYRROLIDONE AS AN AUXILIARY | |
| WO2007047948A3 (en) | Intranasal administration of rapid acting insulin | |
| CA2352483A1 (en) | Pharmaceutical aerosol composition containing hfa 227 and hfa 134a | |
| CA2492976A1 (en) | Solution for ungual and peri-ungual application | |
| NZ517166A (en) | Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonists | |
| PH12014501713A1 (en) | Novel pharmaceutical formulations | |
| WO2007090822A3 (en) | Pharmaceutical formulation for aerosols, comprising two or more active agents and at least one surfactant | |
| WO2007014124A3 (en) | High drug load formulations and dosage forms | |
| TNSN07289A1 (en) | Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a sequestering agent | |
| DE60225421D1 (en) | INHALER WITH AGENTS FOR IMPROVING THE CHEMICAL STABILITY OF A MEDICAL AEROSOL SOLUTION CONTAINING THEREIN | |
| SE0002476D0 (en) | New compounds | |
| UA88894C2 (en) | Stable pharmaceutical solution formulation for pressurized metered dose inhalers | |
| NZ547376A (en) | Transdermal pharmaceutical spray formulations comprising a VP/VA copolymer and a non-aqueous vehicle | |
| WO2007020204A3 (en) | Hfc solution formulations for inhalation containing salbutamol hydrochloride or salbutamol citrate | |
| JO2709B1 (en) | Stable Medicinal Solution Formulations for Pressurized Metered Dose Inhalers. | |
| NO20064359L (en) | Stable pharmaceutical solution formulation for pressurized dosage inhaler | |
| AR048418A1 (en) | FORMULATIONS OF STABLE MEDICINAL SOLUTIONS FOR PRESSURIZED CARTRIDGE INHALERS | |
| TH76283A (en) | Stable solution formulation for nebulization equipment. | |
| GEP20053649B (en) | Stable Pharmaceutical Solution Formulations for Pressurised Metered Dose Inhalers | |
| YU87902A (en) | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |