UA88772C2 - Соединения для лечения расстройств метаболизма - Google Patents
Соединения для лечения расстройств метаболизмаInfo
- Publication number
- UA88772C2 UA88772C2 UAA200602860A UAA200602860A UA88772C2 UA 88772 C2 UA88772 C2 UA 88772C2 UA A200602860 A UAA200602860 A UA A200602860A UA A200602860 A UAA200602860 A UA A200602860A UA 88772 C2 UA88772 C2 UA 88772C2
- Authority
- UA
- Ukraine
- Prior art keywords
- carbon atoms
- ris
- alkyl
- hydrogen
- ring
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000030159 metabolic disease Diseases 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010006895 Cachexia Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000010706 fatty liver disease Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- -1 perfluoromethoxy Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49653303P | 2003-08-20 | 2003-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA88772C2 true UA88772C2 (ru) | 2009-11-25 |
Family
ID=34216015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200602860A UA88772C2 (ru) | 2003-08-20 | 2004-08-16 | Соединения для лечения расстройств метаболизма |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7906675B2 (ru) |
| EP (1) | EP1656127B1 (ru) |
| JP (1) | JP4703563B2 (ru) |
| KR (1) | KR101069276B1 (ru) |
| CN (2) | CN101948416A (ru) |
| AT (1) | ATE502631T1 (ru) |
| AU (1) | AU2004266673B2 (ru) |
| BR (1) | BRPI0413758A (ru) |
| CA (1) | CA2533890A1 (ru) |
| DE (1) | DE602004031954D1 (ru) |
| IL (1) | IL173377A (ru) |
| MX (1) | MXPA06001963A (ru) |
| NO (1) | NO20060502L (ru) |
| NZ (1) | NZ545268A (ru) |
| RU (1) | RU2349584C2 (ru) |
| UA (1) | UA88772C2 (ru) |
| WO (1) | WO2005018628A1 (ru) |
| ZA (1) | ZA200600577B (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4697962B2 (ja) * | 2003-02-13 | 2011-06-08 | ウェルスタット セラピューティクス コーポレイション | 代謝性障害の処置のための化合物 |
| CA2521621C (en) * | 2003-04-15 | 2011-11-01 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| AU2004237602B2 (en) * | 2003-04-30 | 2009-05-28 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| WO2006127133A2 (en) * | 2005-04-01 | 2006-11-30 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| UA95613C2 (ru) * | 2005-11-09 | 2011-08-25 | Уеллстат Терепьютикс Корпорейшн | Соединения для лечения расстройсв метаболизма |
| KR20080089453A (ko) * | 2006-01-25 | 2008-10-06 | 웰스태트 테러퓨틱스 코포레이션 | 물질대사 장애의 치료용 화합물 |
| US7820721B2 (en) * | 2006-01-25 | 2010-10-26 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| WO2007087506A2 (en) * | 2006-01-25 | 2007-08-02 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| KR20080097418A (ko) * | 2006-02-02 | 2008-11-05 | 웰스태트 테러퓨틱스 코포레이션 | 물질대사 장애의 치료용 화합물 |
| US8044243B2 (en) * | 2006-02-13 | 2011-10-25 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| JP2009528375A (ja) * | 2006-02-28 | 2009-08-06 | ウェルスタット セラピューティクス コーポレイション | 代謝障害を処置するための化合物 |
| CA2647258A1 (en) * | 2006-03-31 | 2007-10-18 | Wellstat Therapeutics Corporation | Combination treatment of metabolic disorders |
| AU2007253929B2 (en) * | 2006-05-18 | 2011-07-21 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| MX2008015640A (es) * | 2006-06-09 | 2009-01-09 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de trastornos metabolicos. |
| WO2009091732A1 (en) * | 2008-01-15 | 2009-07-23 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| CN109096350B (zh) * | 2017-09-21 | 2020-07-28 | 暨南大学 | 辣木籽中新的硫醚类化合物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR5035M (ru) | 1964-07-28 | 1967-05-02 | ||
| EP2283834B1 (en) * | 1997-03-17 | 2016-07-13 | BTG International Limited | Therapeutic compositions comprising ketone bodies or their precursors |
| EP1461323B1 (en) * | 2001-06-12 | 2013-10-09 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| JP2006507303A (ja) * | 2002-11-01 | 2006-03-02 | ウェルスタット セラピューティクス コーポレイション | 代謝障害の処置のための化合物 |
| JP4697962B2 (ja) * | 2003-02-13 | 2011-06-08 | ウェルスタット セラピューティクス コーポレイション | 代謝性障害の処置のための化合物 |
| CA2521621C (en) * | 2003-04-15 | 2011-11-01 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| ATE450496T1 (de) * | 2003-04-22 | 2009-12-15 | Wellstat Therapeutics Corp | Verbindungen zur behandlung von stoffwechselstörungen |
| AU2004237602B2 (en) * | 2003-04-30 | 2009-05-28 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
-
2004
- 2004-08-16 JP JP2006523964A patent/JP4703563B2/ja not_active Expired - Fee Related
- 2004-08-16 US US10/566,302 patent/US7906675B2/en active Active
- 2004-08-16 CN CN2010102937097A patent/CN101948416A/zh active Pending
- 2004-08-16 UA UAA200602860A patent/UA88772C2/ru unknown
- 2004-08-16 AU AU2004266673A patent/AU2004266673B2/en not_active Ceased
- 2004-08-16 DE DE602004031954T patent/DE602004031954D1/de not_active Expired - Lifetime
- 2004-08-16 RU RU2006108572/04A patent/RU2349584C2/ru not_active IP Right Cessation
- 2004-08-16 EP EP04781277A patent/EP1656127B1/en not_active Expired - Lifetime
- 2004-08-16 MX MXPA06001963A patent/MXPA06001963A/es active IP Right Grant
- 2004-08-16 CA CA002533890A patent/CA2533890A1/en not_active Abandoned
- 2004-08-16 CN CNA2004800235529A patent/CN1835743A/zh active Pending
- 2004-08-16 WO PCT/US2004/026561 patent/WO2005018628A1/en not_active Ceased
- 2004-08-16 BR BRPI0413758-2A patent/BRPI0413758A/pt not_active IP Right Cessation
- 2004-08-16 NZ NZ545268A patent/NZ545268A/en unknown
- 2004-08-16 KR KR1020067003221A patent/KR101069276B1/ko not_active Expired - Fee Related
- 2004-08-16 AT AT04781277T patent/ATE502631T1/de not_active IP Right Cessation
-
2006
- 2006-01-23 ZA ZA200600577A patent/ZA200600577B/en unknown
- 2006-01-26 IL IL173377A patent/IL173377A/en not_active IP Right Cessation
- 2006-01-31 NO NO20060502A patent/NO20060502L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004266673B2 (en) | 2010-08-05 |
| CA2533890A1 (en) | 2005-03-03 |
| AU2004266673A1 (en) | 2005-03-03 |
| US7906675B2 (en) | 2011-03-15 |
| RU2349584C2 (ru) | 2009-03-20 |
| JP2007502824A (ja) | 2007-02-15 |
| JP4703563B2 (ja) | 2011-06-15 |
| MXPA06001963A (es) | 2006-05-31 |
| KR101069276B1 (ko) | 2011-10-04 |
| CN101948416A (zh) | 2011-01-19 |
| DE602004031954D1 (de) | 2011-05-05 |
| EP1656127A1 (en) | 2006-05-17 |
| HK1087040A1 (en) | 2006-10-06 |
| WO2005018628A1 (en) | 2005-03-03 |
| IL173377A (en) | 2012-12-31 |
| BRPI0413758A (pt) | 2006-10-31 |
| EP1656127B1 (en) | 2011-03-23 |
| CN1835743A (zh) | 2006-09-20 |
| ZA200600577B (en) | 2007-01-31 |
| IL173377A0 (en) | 2006-06-11 |
| EP1656127A4 (en) | 2009-04-29 |
| RU2006108572A (ru) | 2006-07-27 |
| US20070282003A1 (en) | 2007-12-06 |
| ATE502631T1 (de) | 2011-04-15 |
| KR20060066730A (ko) | 2006-06-16 |
| NZ545268A (en) | 2009-05-31 |
| NO20060502L (no) | 2006-05-03 |
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