UA87685C2 - Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes - Google Patents
Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetesInfo
- Publication number
- UA87685C2 UA87685C2 UAA200612279A UAA200612279A UA87685C2 UA 87685 C2 UA87685 C2 UA 87685C2 UA A200612279 A UAA200612279 A UA A200612279A UA A200612279 A UAA200612279 A UA A200612279A UA 87685 C2 UA87685 C2 UA 87685C2
- Authority
- UA
- Ukraine
- Prior art keywords
- het
- ris
- optionally substituted
- membered
- linked
- Prior art date
Links
- 239000012190 activator Substances 0.000 title abstract 2
- 150000003936 benzamides Chemical class 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of Formula (I) wherein: Ris hydroxymethyl; Ris selected from -C(O)NRR, SONRR, S(O)Rand HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; Ris selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; Ris selected from for example hydrogen, optionally substituted (l-4C)alkyl and HET-2; Ris hydrogen or (1 -4C)alkyl; or Rand Rtogether with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.(I)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0412602.5A GB0412602D0 (en) | 2004-06-05 | 2004-06-05 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA87685C2 true UA87685C2 (en) | 2009-08-10 |
Family
ID=32696738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200612279A UA87685C2 (en) | 2004-06-05 | 2005-06-01 | Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN101018773A (en) |
| GB (1) | GB0412602D0 (en) |
| UA (1) | UA87685C2 (en) |
| ZA (1) | ZA200610140B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2511265A1 (en) * | 2009-12-11 | 2012-10-17 | Astellas Pharma Inc. | Benzamide compound |
-
2004
- 2004-06-05 GB GBGB0412602.5A patent/GB0412602D0/en not_active Ceased
-
2005
- 2005-06-01 UA UAA200612279A patent/UA87685C2/en unknown
- 2005-06-01 CN CNA2005800254863A patent/CN101018773A/en active Pending
-
2006
- 2006-12-04 ZA ZA200610140A patent/ZA200610140B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0412602D0 (en) | 2004-07-07 |
| CN101018773A (en) | 2007-08-15 |
| ZA200610140B (en) | 2009-03-25 |
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