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UA86301C2 - Oxyindole derivatives as 5ht4 receptor agonists - Google Patents

Oxyindole derivatives as 5ht4 receptor agonists Download PDF

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Publication number
UA86301C2
UA86301C2 UAA200709522A UAA200709522A UA86301C2 UA 86301 C2 UA86301 C2 UA 86301C2 UA A200709522 A UAA200709522 A UA A200709522A UA A200709522 A UAA200709522 A UA A200709522A UA 86301 C2 UA86301 C2 UA 86301C2
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Ukraine
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stage
reaction
methyl
compound
group
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UAA200709522A
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English (en)
Ukrainian (uk)
Inventor
Кийоси Кавамура
Хироки Сонэ
Тикара Утида
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Пфайзер Инк.
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Publication of UA86301C2 publication Critical patent/UA86301C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Изобретение касается соединений формулы (І) или их фармацевтически приемлемой соли, где каждый из заместителей A, R, R, RRи Rздесь описан, или фармацевтически приемлемых солей и композиций, которые содержат такие соединения, а также использование таких соединений при лечении состояний, опосредованных агонистической активностью 5-НТ, таких как, кроме прочих, рефлюксная гастроэзофагеальная болезнь, желудочно-кишечное заболевание, расстройство подвижной функции желудка, неязвенная диспепсия, функциональная диспепсия, синдром раздраженной толстой кишки, констипация, диспепсия, эзофагит, гастроэзофагеальная болезнь, тошнота, заболевания центральной нервной системы, болезнь Альцгеймера, расстройство познавательной способности, рвота, мигрень, неврологическое заболевание, боль, сердечно-сосудистые расс
UAA200709522A 2005-02-22 2006-10-02 Oxyindole derivatives as 5ht4 receptor agonists UA86301C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65527605P 2005-02-22 2005-02-22

Publications (1)

Publication Number Publication Date
UA86301C2 true UA86301C2 (en) 2009-04-10

Family

ID=36579484

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200709522A UA86301C2 (en) 2005-02-22 2006-10-02 Oxyindole derivatives as 5ht4 receptor agonists

Country Status (31)

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US (2) US7589109B2 (ru)
EP (1) EP1856110B1 (ru)
JP (1) JP4130220B1 (ru)
KR (1) KR100908547B1 (ru)
CN (1) CN101522668B (ru)
AP (1) AP2007004067A0 (ru)
AR (1) AR053548A1 (ru)
AT (1) ATE513827T1 (ru)
AU (1) AU2006217534B8 (ru)
BR (1) BRPI0607456A2 (ru)
CA (1) CA2598536C (ru)
DK (1) DK1856110T3 (ru)
DO (1) DOP2006000046A (ru)
EA (1) EA012615B1 (ru)
ES (1) ES2366375T3 (ru)
GE (1) GEP20094727B (ru)
GT (1) GT200600083A (ru)
HN (1) HN2006007884A (ru)
IL (1) IL184505A0 (ru)
MA (1) MA29260B1 (ru)
MX (1) MX2007010139A (ru)
NL (1) NL1031218C2 (ru)
NO (1) NO20073566L (ru)
NZ (1) NZ556627A (ru)
PE (1) PE20061096A1 (ru)
TN (1) TNSN07319A1 (ru)
TW (1) TW200640915A (ru)
UA (1) UA86301C2 (ru)
UY (1) UY29389A1 (ru)
WO (1) WO2006090279A1 (ru)
ZA (1) ZA200706420B (ru)

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Also Published As

Publication number Publication date
UY29389A1 (es) 2006-10-02
MA29260B1 (fr) 2008-02-01
AU2006217534A1 (en) 2006-08-31
JP2008531543A (ja) 2008-08-14
EP1856110B1 (en) 2011-06-22
NZ556627A (en) 2010-09-30
US20100173925A1 (en) 2010-07-08
DK1856110T3 (da) 2011-08-15
DOP2006000046A (es) 2006-08-31
US7589109B2 (en) 2009-09-15
AR053548A1 (es) 2007-05-09
HN2006007884A (es) 2010-01-18
TNSN07319A1 (fr) 2008-12-31
CA2598536C (en) 2011-04-05
JP4130220B1 (ja) 2008-08-06
MX2007010139A (es) 2007-09-27
EA200701552A1 (ru) 2007-12-28
WO2006090279A1 (en) 2006-08-31
CA2598536A1 (en) 2006-08-31
ATE513827T1 (de) 2011-07-15
EP1856110A1 (en) 2007-11-21
KR20070098936A (ko) 2007-10-05
EA012615B1 (ru) 2009-10-30
IL184505A0 (en) 2007-10-31
NL1031218A1 (nl) 2006-08-23
NL1031218C2 (nl) 2007-01-23
NO20073566L (no) 2007-08-08
CN101522668B (zh) 2012-06-06
CN101522668A (zh) 2009-09-02
AU2006217534B2 (en) 2011-08-11
AU2006217534A8 (en) 2011-12-08
HK1135966A1 (en) 2010-06-18
ZA200706420B (en) 2009-04-29
BRPI0607456A2 (pt) 2009-09-08
GEP20094727B (en) 2009-07-10
AU2006217534B8 (en) 2011-12-08
GT200600083A (es) 2006-11-07
ES2366375T3 (es) 2011-10-19
TW200640915A (en) 2006-12-01
PE20061096A1 (es) 2006-11-09
KR100908547B1 (ko) 2009-07-20
AP2007004067A0 (en) 2007-08-31
US20060194842A1 (en) 2006-08-31

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