UA86946C2 - T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds - Google Patents
T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compoundsInfo
- Publication number
- UA86946C2 UA86946C2 UAA200602392A UAA200602392A UA86946C2 UA 86946 C2 UA86946 C2 UA 86946C2 UA A200602392 A UAA200602392 A UA A200602392A UA A200602392 A UAA200602392 A UA A200602392A UA 86946 C2 UA86946 C2 UA 86946C2
- Authority
- UA
- Ukraine
- Prior art keywords
- receptors
- taste
- compounds
- hetero
- express
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 108091005708 gustatory receptors Proteins 0.000 title abstract 2
- 108020003175 receptors Proteins 0.000 title abstract 2
- 101000659774 Homo sapiens Taste receptor type 1 member 3 Proteins 0.000 abstract 6
- 102100035942 Taste receptor type 1 member 3 Human genes 0.000 abstract 6
- 101000659767 Homo sapiens Taste receptor type 1 member 1 Proteins 0.000 abstract 3
- 101000659765 Homo sapiens Taste receptor type 1 member 2 Proteins 0.000 abstract 3
- 102100035941 Taste receptor type 1 member 1 Human genes 0.000 abstract 3
- 102100035948 Taste receptor type 1 member 2 Human genes 0.000 abstract 3
- 235000019605 sweet taste sensations Nutrition 0.000 abstract 2
- 235000019583 umami taste Nutrition 0.000 abstract 2
- 235000019607 umami taste sensations Nutrition 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 238000000423 cell based assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000012188 high-throughput screening assay Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- General Preparation And Processing Of Foods (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or subunits thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49407103P | 2003-08-06 | 2003-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA86946C2 true UA86946C2 (en) | 2009-06-10 |
Family
ID=38783493
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200602392A UA86946C2 (en) | 2003-08-06 | 2004-08-06 | T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds |
| UAA200602393A UA92887C2 (en) | 2003-08-06 | 2004-08-06 | Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200602393A UA92887C2 (en) | 2003-08-06 | 2004-08-06 | Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
Country Status (5)
| Country | Link |
|---|---|
| CN (2) | CN101400336B (en) |
| AR (1) | AR098722A2 (en) |
| CA (1) | CA2827128C (en) |
| UA (2) | UA86946C2 (en) |
| ZA (3) | ZA200702833B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2597438C2 (en) * | 2010-04-15 | 2016-09-10 | Крафт Фудс Груп Брэндс Ллс | Compounds, compositions and methods for reducing or eliminating bitter taste |
| ES2433004T3 (en) * | 2011-05-31 | 2013-12-05 | Symrise Ag | Cinnamic acid amides as spicy saporiferous substances |
| CN102311422A (en) * | 2011-07-11 | 2012-01-11 | 上海应用技术学院 | N-(hept-4-yl) benzo [d] [1, 3] dioxole-5-methanamide and synthetic method thereof |
| CN103156154A (en) * | 2011-12-09 | 2013-06-19 | 味之素株式会社 | Sweetening agent composition and drink food |
| CN105418449A (en) * | 2015-12-15 | 2016-03-23 | 中国船舶重工集团公司第七二五研究所 | Phenolic amide type anti-fouling agents containing benzene ring with methoxyl and preparation method of phenolic amide type anti-fouling agents |
| US10209239B1 (en) * | 2017-08-16 | 2019-02-19 | Aromyx Corporation | Method of making an aromagraph comprising ectopic olfactory receptors |
| CN109535100A (en) * | 2018-12-26 | 2019-03-29 | 常茂生物化学工程股份有限公司 | The preparation method of L-aspartyl-L-phenylalanine methylester acesulfame |
| WO2020172276A1 (en) * | 2019-02-20 | 2020-08-27 | Gregory Aharonian | Methods and compositions for improving the taste of diet cola sodas and other beverages |
| CN111175299B (en) * | 2019-11-22 | 2022-08-05 | 浙江农林大学 | Sweet taste solution detection method based on cell image recognition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5176928A (en) * | 1988-08-04 | 1993-01-05 | The Nutrasweet Company | Reduced calorie diary mix |
-
2004
- 2004-08-06 UA UAA200602392A patent/UA86946C2/en unknown
- 2004-08-06 UA UAA200602393A patent/UA92887C2/en unknown
- 2004-08-06 ZA ZA200702833A patent/ZA200702833B/en unknown
- 2004-08-06 ZA ZA200601903A patent/ZA200601903B/en unknown
- 2004-08-06 CA CA2827128A patent/CA2827128C/en not_active Expired - Fee Related
- 2004-08-06 CN CN200480022556.5A patent/CN101400336B/en not_active Expired - Lifetime
- 2004-08-06 CN CN 200480022612 patent/CN101052725A/en active Pending
-
2007
- 2007-04-04 ZA ZA200702832A patent/ZA200702832B/en unknown
-
2014
- 2014-12-11 AR ARP140104621A patent/AR098722A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN101052725A (en) | 2007-10-10 |
| AR098722A2 (en) | 2016-06-08 |
| ZA200702832B (en) | 2008-11-26 |
| CN101400336A (en) | 2009-04-01 |
| CA2827128C (en) | 2018-03-27 |
| ZA200601903B (en) | 2007-06-27 |
| CN101400336B (en) | 2013-06-05 |
| UA92887C2 (en) | 2010-12-27 |
| ZA200702833B (en) | 2008-11-26 |
| CA2827128A1 (en) | 2005-02-17 |
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