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UA84896C2 - Производные гидронопола как агонисты человеческих рецепторов orl1 - Google Patents

Производные гидронопола как агонисты человеческих рецепторов orl1

Info

Publication number
UA84896C2
UA84896C2 UAA200607374A UAA200607374A UA84896C2 UA 84896 C2 UA84896 C2 UA 84896C2 UA A200607374 A UAA200607374 A UA A200607374A UA A200607374 A UAA200607374 A UA A200607374A UA 84896 C2 UA84896 C2 UA 84896C2
Authority
UA
Ukraine
Prior art keywords
agonists
receptors
hydronopol
derivatives
relates
Prior art date
Application number
UAA200607374A
Other languages
English (en)
Ukrainian (uk)
Inventor
Матиас Менцель
Даниа Б. Райхе
Райнхард Брюкнер
Самуэль Давид
Стин Бартоломеус Й. ван
Уве Шон
Даниэль Жассеран
Ульф Пройшофф
Original Assignee
Сольве Фармасьютикалз Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сольве Фармасьютикалз Гмбх filed Critical Сольве Фармасьютикалз Гмбх
Publication of UA84896C2 publication Critical patent/UA84896C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение касается группы производных гидронопола, которые являются агонистами человеческих рецепторов ORL1 (ноцицептина).Изобретение также касается способов получения этих соединений, фармацевтических композиций, которые содержат фармакологически активное количество, по крайней мере, одного из этих новых производных гидронопола как действующего вещества, а также применения этих фармацевтических композиций для лечения расстройств, связанных с рецепторами ORL1.Изобретение касается соединений общей формулы (1),где радикалы имеют значения, которые приведены в описании.
UAA200607374A 2003-12-12 2004-12-09 Производные гидронопола как агонисты человеческих рецепторов orl1 UA84896C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03104662 2003-12-12

Publications (1)

Publication Number Publication Date
UA84896C2 true UA84896C2 (ru) 2008-12-10

Family

ID=34924140

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200607374A UA84896C2 (ru) 2003-12-12 2004-12-09 Производные гидронопола как агонисты человеческих рецепторов orl1

Country Status (14)

Country Link
US (1) US7241770B2 (ru)
EP (1) EP1694675A2 (ru)
JP (1) JP2007513922A (ru)
CN (1) CN1890238A (ru)
AR (1) AR046756A1 (ru)
AU (1) AU2004298436A1 (ru)
BR (1) BRPI0417161A (ru)
CA (1) CA2547633A1 (ru)
MX (1) MXPA06005675A (ru)
RU (1) RU2351600C2 (ru)
TW (1) TW200522949A (ru)
UA (1) UA84896C2 (ru)
WO (1) WO2005058890A2 (ru)
ZA (1) ZA200604791B (ru)

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AR045843A1 (es) * 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
AU2006322060A1 (en) 2005-12-05 2007-06-14 Incyte Corporation Lactam compounds and methods of using the same
AU2007260984A1 (en) * 2006-06-20 2007-12-27 Wyeth Kv1.5 potassium channel inhibitors
RU2458902C1 (ru) * 2011-07-08 2012-08-20 Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН Способ получения миртанола
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
WO2014102594A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
US9040533B2 (en) 2012-12-27 2015-05-26 Purdue Pharma L.P. Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
CN105531251A (zh) * 2013-09-12 2016-04-27 信越化学工业株式会社 用于制备环薰衣草醇及其衍生物的方法
JP6208103B2 (ja) 2013-09-12 2017-10-04 信越化学工業株式会社 β−シクロラバンジュラール及びその誘導体の製造方法
CN104557653A (zh) * 2014-12-31 2015-04-29 大连联化化学有限公司 7-甲基-氮杂-二环[4,1,0]庚烷的制备方法
TN2017000544A1 (en) 2015-07-31 2019-04-12 Pfizer 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors
JP7011596B2 (ja) 2015-12-02 2022-02-10 アストライア セラピューティクス， エルエルシー ピペリジニルノシセプチン受容体化合物
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
IL291323B2 (en) 2016-07-15 2023-09-01 Am Chemicals Llc Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis
SG11201906417RA (en) 2017-01-20 2019-08-27 Pfizer 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors
JP2020506903A (ja) 2017-01-23 2020-03-05 ファイザー・インク Ｍａｇｌ阻害薬としての複素環式スピロ化合物
IT201800007580A1 (it) * 2018-07-27 2020-01-27 Maria Cecilia Hospital Spa Composti 1,3,8-triazaspiro e loro uso come medicamenti
CN116410143A (zh) * 2021-12-29 2023-07-11 杭州奥默医药股份有限公司 一种多取代脲嘧啶衍生物及其制备方法和应用
CN115124441B (zh) * 2022-06-30 2024-04-02 南京林业大学 一类诺卜酸酰肼类化合物的制备方法和产品及其应用

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US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ATE289307T1 (de) * 1998-10-23 2005-03-15 Pfizer 1,3,8-triazaspiro(4,5) decanon verbindungen als orl1-receptor agonisten
JP2000169476A (ja) * 1998-12-09 2000-06-20 Banyu Pharmaceut Co Ltd ４−オキソイミダゾリジン−５−スピロ−含窒素複素環式化合物
AR030676A1 (es) * 1999-07-28 2003-09-03 Ortho Mcneil Pharm Inc Derivados de aminas y amidas como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de la obesidad y otros trastornos, uso de los mismos para la elaboracion de medicamentos y composiciones farmaceuticas que los comprenden
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MXPA05002622A (es) 2002-09-09 2005-09-08 Johnson & Johnson Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano.

Also Published As

Publication number Publication date
WO2005058890A3 (en) 2005-08-18
BRPI0417161A (pt) 2007-03-06
CN1890238A (zh) 2007-01-03
RU2006124856A (ru) 2008-01-20
RU2351600C2 (ru) 2009-04-10
EP1694675A2 (en) 2006-08-30
MXPA06005675A (es) 2006-08-17
US7241770B2 (en) 2007-07-10
TW200522949A (en) 2005-07-16
AR046756A1 (es) 2005-12-21
CA2547633A1 (en) 2005-06-30
WO2005058890A2 (en) 2005-06-30
JP2007513922A (ja) 2007-05-31
US20050131004A1 (en) 2005-06-16
ZA200604791B (en) 2008-07-30
AU2004298436A1 (en) 2005-06-30

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