UA82328C2 - Парентеральная композиция на основе гидроксиэстера рапамицина (варианты) и способ ее приготовления - Google Patents

Парентеральная композиция на основе гидроксиэстера рапамицина (варианты) и способ ее приготовления Download PDF

Info

Publication number: UA82328C2
Authority: UA; Ukraine
Prior art keywords: polyethylene glycol; ssi; solvent; polysorbate; antioxidant
Prior art date: 2002-07-30

Application number

UAA200501758A

Other languages

English (en)

Ukrainian (uk)

Inventor

Джозеф Т. Рубино

Виктория Сискавич

Морин М. Харрисон

Пойа Ганди

Original Assignee

Уайт

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-30

Filing date

2003-07-25

Publication date

2008-04-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31188593&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA82328(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-07-25 Application filed by Уайт filed Critical Уайт

2008-04-10 Publication of UA82328C2 publication Critical patent/UA82328C2/ru

Links

239000000203 mixture Substances 0.000 title claims abstract description 84
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ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract description 10
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract description 9
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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UAA200501758A 2002-07-30 2003-07-25 Парентеральная композиция на основе гидроксиэстера рапамицина (варианты) и способ ее приготовления UA82328C2 (ru)

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US39952602P	2002-07-30	2002-07-30
PCT/US2003/023276 WO2004011000A1 (en)	2002-07-30	2003-07-25	Parenteral formulations containing a rapamycin hydroxyester

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US (4)	US8026276B2 (ru)
EP (1)	EP1553940B1 (ru)
JP (2)	JP2005537285A (ru)
KR (1)	KR101131794B1 (ru)
CN (1)	CN100402031C (ru)
AR (2)	AR040693A1 (ru)
AT (1)	ATE385795T1 (ru)
AU (2)	AU2003254168A1 (ru)
BR (1)	BR0313024A (ru)
CA (1)	CA2493878C (ru)
CO (1)	CO5700745A2 (ru)
CR (1)	CR7647A (ru)
DE (1)	DE60319118T2 (ru)
DK (1)	DK1553940T3 (ru)
EC (1)	ECSP055628A (ru)
ES (1)	ES2300622T3 (ru)
IL (1)	IL166003A (ru)
MX (1)	MXPA05001013A (ru)
NO (1)	NO20050455L (ru)
NZ (1)	NZ537829A (ru)
PT (1)	PT1553940E (ru)
RU (1)	RU2344821C2 (ru)
SI (1)	SI1553940T1 (ru)
TW (1)	TWI307277B (ru)
UA (1)	UA82328C2 (ru)
WO (1)	WO2004011000A1 (ru)
ZA (1)	ZA200500831B (ru)

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Also Published As

Publication number	Publication date
AR040693A1 (es)	2005-04-13
AR090603A2 (es)	2014-11-26
US20130252998A1 (en)	2013-09-26
SI1553940T1 (sl)	2008-08-31
US8026276B2 (en)	2011-09-27
TWI307277B (en)	2009-03-11
AU2010200761B2 (en)	2011-10-13
JP5345105B2 (ja)	2013-11-20
CN100402031C (zh)	2008-07-16
KR20050026025A (ko)	2005-03-14
DE60319118D1 (de)	2008-03-27
ZA200500831B (en)	2007-07-25
NZ537829A (en)	2006-09-29
WO2004011000A1 (en)	2004-02-05
ECSP055628A (es)	2005-05-30
ATE385795T1 (de)	2008-03-15
TW200403073A (en)	2004-03-01
US8455539B2 (en)	2013-06-04
CN1671385A (zh)	2005-09-21
DK1553940T3 (da)	2008-06-02
RU2005105301A (ru)	2005-09-10
DE60319118T2 (de)	2009-02-05
CA2493878A1 (en)	2004-02-05
US8299116B2 (en)	2012-10-30
US20040167152A1 (en)	2004-08-26
AU2010200761A1 (en)	2010-03-18
US20130040980A1 (en)	2013-02-14
IL166003A (en)	2009-05-04
HK1076390A1 (en)	2006-01-20
JP2005537285A (ja)	2005-12-08
CO5700745A2 (es)	2006-11-30
US20110294845A1 (en)	2011-12-01
AU2003254168A1 (en)	2004-02-16
MXPA05001013A (es)	2005-05-16
PT1553940E (pt)	2008-05-09
IL166003A0 (en)	2006-01-15
RU2344821C2 (ru)	2009-01-27
KR101131794B1 (ko)	2012-03-30
CR7647A (es)	2006-05-26
ES2300622T3 (es)	2008-06-16
CA2493878C (en)	2013-07-23
NO20050455L (no)	2005-02-09
JP2010163466A (ja)	2010-07-29
US8722700B2 (en)	2014-05-13
BR0313024A (pt)	2005-07-12
EP1553940A1 (en)	2005-07-20
EP1553940B1 (en)	2008-02-13

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WO2014118696A2 (en)	2014-08-07	Pharmacuetical compositions of rapamycin esters and its derivatives
WO2014075554A1 (zh)	2014-05-22	含有西罗莫司酯化物的药物组合物及其制备方法
JPS6185320A (ja)	1986-04-30	抗腫瘍剤効果増強剤
HK1076390B (en)	2008-07-18	Parenteral formulations containing a rapamycin hydroxyester