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UA82208C2 - 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors - Google Patents

4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors Download PDF

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Publication number
UA82208C2
UA82208C2 UAA200506089A UA2005006089A UA82208C2 UA 82208 C2 UA82208 C2 UA 82208C2 UA A200506089 A UAA200506089 A UA A200506089A UA 2005006089 A UA2005006089 A UA 2005006089A UA 82208 C2 UA82208 C2 UA 82208C2
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UA
Ukraine
Prior art keywords
oxo
carbonyl
biphenyl
acid
trans
Prior art date
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UAA200506089A
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English (en)
Ukrainian (uk)
Inventor
Даниэль Дюб
Мишель ГАЛЛАН
Патрик Лякомб
Рене Аспиотис
Лоранс Дюб
Ив Жирар
Дуайт Макдональд
Original Assignee
Мерк Фросст Кенада Лтд
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Application filed by Мерк Фросст Кенада Лтд filed Critical Мерк Фросст Кенада Лтд
Publication of UA82208C2 publication Critical patent/UA82208C2/uk

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Соединения, представленные формулой (І), или их фармацевтически приемлемые соли, которые являются ингибиторами фосфодиэстеразы-4, пригодными для лечения астмы и воспаления, а также для улучшения познавательной способности.
UAA200506089A 2002-11-22 2003-11-19 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors UA82208C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42861102P 2002-11-22 2002-11-22
PCT/CA2003/001800 WO2004048374A1 (en) 2002-11-22 2003-11-19 4-oxo-1-(3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors

Publications (1)

Publication Number Publication Date
UA82208C2 true UA82208C2 (en) 2008-03-25

Family

ID=32393431

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200506089A UA82208C2 (en) 2002-11-22 2003-11-19 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors

Country Status (23)

Country Link
US (2) US7342024B2 (ru)
EP (1) EP1565464B1 (ru)
JP (1) JP4499571B2 (ru)
KR (1) KR20050085112A (ru)
CN (1) CN100475813C (ru)
AT (1) ATE402175T1 (ru)
AU (1) AU2003283167B2 (ru)
BR (1) BR0316458A (ru)
CA (1) CA2506648C (ru)
CL (1) CL2004001050A1 (ru)
DE (1) DE60322417D1 (ru)
EC (1) ECSP055809A (ru)
HR (1) HRP20050451A2 (ru)
IS (1) IS7839A (ru)
MA (1) MA27566A1 (ru)
MX (1) MXPA05005413A (ru)
NO (1) NO20053046L (ru)
NZ (1) NZ539812A (ru)
PL (1) PL377237A1 (ru)
RU (1) RU2312865C2 (ru)
UA (1) UA82208C2 (ru)
WO (1) WO2004048374A1 (ru)
ZA (1) ZA200503586B (ru)

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JO2311B1 (en) * 2001-08-29 2005-09-12 ميرك فروست كندا ليمتد Alkyl inhibitors Ariel phosphodiesterase-4
IS7839A (is) * 2002-11-22 2004-05-23 Merck Frosst Canada Ltd. 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
EP1981885A2 (en) * 2005-10-27 2008-10-22 Merck & Co., Inc. A method of preparing a 4-oxo-1-(3-substituted phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitor
AR057555A1 (es) * 2005-10-27 2007-12-05 Merck Frosst Canada Ltd Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparacion del mismo
RS53461B (sr) 2006-07-05 2014-12-31 Takeda Gmbh Kombinacija inhibitora hmg-coa reduktaze atorvastatina ili simvastatina sa fosfodiesteraza 4 inhibitorom, kao što je roflumilast za lečenje inflamatornih pulmonarnih oboljenja
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
EP2540722B1 (en) * 2006-10-16 2016-06-08 Bionomics Limited Novel anxiolytic compounds
NZ579645A (en) * 2007-03-14 2012-01-12 Ranbaxy Lab Ltd Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
JP2010523695A (ja) * 2007-04-11 2010-07-15 アルコン リサーチ， リミテッド アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのＴＮＦαのインヒビターおよび抗ヒスタミン薬の使用
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
EP2297106B1 (en) 2008-05-27 2014-07-16 AstraZeneca AB Phenoxypyridinylamide derivatives and their use in the treatment of pde4 mediated disease states
US20110082145A1 (en) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
EP2587919B1 (en) * 2010-07-01 2017-12-13 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
WO2012116415A1 (en) 2011-03-02 2012-09-07 Bionomics Limited Novel small-molecules as therapeutics
AU2012253237B2 (en) 2011-05-12 2015-09-24 Bionomics Limited Methods for preparing naphthyridines
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CN104428292B (zh) * 2012-06-15 2017-02-08 生物药品解决方案有限公司 氨基磺酸苯基烷基酯化合物及包含所述化合物的肌肉松弛组合物
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
CN106316824B (zh) * 2016-08-18 2018-10-19 广州康瑞泰药业有限公司 一种合成2-氟环丙烷甲酸的新方法
RU2747311C2 (ru) * 2016-12-16 2021-05-04 СиСТОУН ФАРМАСЬЮТИКАЛС (СУЧЖОУ) КО., ЛТД. Ингибитор CDK4/6
CN113423435A (zh) 2018-12-28 2021-09-21 雷杰纳荣制药公司 使用花生四烯酸15-脂氧合酶(alox15)抑制剂治疗呼吸系统病症

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Also Published As

Publication number Publication date
CA2506648A1 (en) 2004-06-10
EP1565464B1 (en) 2008-07-23
ZA200503586B (en) 2006-07-26
CN1738819A (zh) 2006-02-22
JP4499571B2 (ja) 2010-07-07
CA2506648C (en) 2011-01-25
MXPA05005413A (es) 2005-08-03
RU2312865C2 (ru) 2007-12-20
JP2006508989A (ja) 2006-03-16
AU2003283167A1 (en) 2004-06-18
IS7839A (is) 2004-05-23
US7238706B2 (en) 2007-07-03
HRP20050451A2 (en) 2006-02-28
CN100475813C (zh) 2009-04-08
US20050107402A1 (en) 2005-05-19
MA27566A1 (fr) 2005-10-03
NO20053046D0 (no) 2005-06-21
CL2004001050A1 (es) 2005-03-28
BR0316458A (pt) 2005-10-11
NO20053046L (no) 2005-07-27
PL377237A1 (pl) 2006-01-23
ECSP055809A (es) 2005-08-11
KR20050085112A (ko) 2005-08-29
US7342024B2 (en) 2008-03-11
ATE402175T1 (de) 2008-08-15
NZ539812A (en) 2007-12-21
RU2005119644A (ru) 2006-01-20
DE60322417D1 (en) 2008-09-04
EP1565464A1 (en) 2005-08-24
AU2003283167B2 (en) 2009-01-08
WO2004048374A1 (en) 2004-06-10
US20060058316A1 (en) 2006-03-16

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