UA82109C2 - Производные пиррол-2,5-дитиона как модуляторы х-рецептора печени - Google Patents
Производные пиррол-2,5-дитиона как модуляторы х-рецептора печени Download PDFInfo
- Publication number
- UA82109C2 UA82109C2 UAA200600272A UAA200600272A UA82109C2 UA 82109 C2 UA82109 C2 UA 82109C2 UA A200600272 A UAA200600272 A UA A200600272A UA A200600272 A UAA200600272 A UA A200600272A UA 82109 C2 UA82109 C2 UA 82109C2
- Authority
- UA
- Ukraine
- Prior art keywords
- phenyl
- treatment
- amino
- pyrrole
- dione
- Prior art date
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- 102000004311 liver X receptors Human genes 0.000 title abstract 5
- 108090000865 liver X receptors Proteins 0.000 title abstract 5
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Заявленное изобретение касается некоторых новых замещенных соединений формулы І, способа получения таких соединений, их применения в модулировании рецепторов ядерных гормонов Х-Рецептора печени (ХРП)(NR1H3) и/или(NR1H2), а также в лечении клинических состояний, включая сердечно-сосудистые болезни, таких как атеросклероз; воспалительные заболевания, болезнь Альцгеймера, липидные расстройства (дислипидемии), ассоциированные или не ассоциированные с резистентностью к инсулину, диабет типа 2 и другие проявления метаболического синдрома, способов их терапевтического применения и фармацевтических композиций, которые их содержат.
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| GBGB0316232.8A GB0316232D0 (en) | 2003-07-11 | 2003-07-11 | Therapeutic agents |
| PCT/SE2004/001114 WO2005005417A1 (en) | 2003-07-11 | 2004-07-08 | Pyrrole-2, 5-dione derivatives as liver x receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82109C2 true UA82109C2 (ru) | 2008-03-11 |
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| EP (1) | EP1646626B1 (ru) |
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1634877B1 (en) * | 2004-08-17 | 2011-06-22 | Simpson Biotech Co., Ltd. | Mixture and compounds from mycelia of antrodia camphorata and use thereof |
| US7505238B2 (en) * | 2005-01-07 | 2009-03-17 | Agnes Neves Woo | ESD configuration for low parasitic capacitance I/O |
| RU2007130152A (ru) | 2005-01-10 | 2009-02-20 | Астразенека Аб (Se) | Производные 1, 1-диоксидов изотиазол-3(2h)-онов в качестве модуляторов печеночных х-рецепторов |
| SE0500055D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 3 |
| ES2433135T3 (es) * | 2006-04-28 | 2013-12-09 | Laboratorios Del Dr. Esteve, S.A. | Compuestos biciclicos de tetrahidropirrol |
| AU2007286807B2 (en) | 2006-08-21 | 2013-03-21 | Genentech, Inc. | Aza-benzothiophenyl compounds and methods of use |
| CN101456863B (zh) * | 2007-12-14 | 2012-04-25 | 华北制药集团新药研究开发有限责任公司 | Lxr激动剂及其制备方法和用途 |
| BRPI0910200A2 (pt) | 2008-07-01 | 2015-09-29 | Genentech Inc | composto, composição farmacêutica, método de inibir o crescimento de células anormais ou de tratar um distúrbio hiperproliferativo em um mamífero e método de tratar uma doença inflamatória em um mamífero |
| US8841462B2 (en) | 2008-07-01 | 2014-09-23 | Robert A. Heald | Bicyclic heterocycles as MEK kinase inhibitors |
| KR101901741B1 (ko) | 2010-09-07 | 2018-10-01 | 서울대학교산학협력단 | 세스터터핀 화합물 및 이들 물질의 용도 |
| CN103354742A (zh) | 2010-12-03 | 2013-10-16 | 阿勒根公司 | 作为鞘氨醇1-磷酸(s1p)受体调节剂的新型肟氮杂环丁烷衍生物 |
| AU2011336970A1 (en) | 2010-12-03 | 2013-07-11 | Allergan, Inc. | Novel oxime derivatives as sphingosine 1-phosphate (S1P) receptor modulators |
| WO2015106164A1 (en) | 2014-01-10 | 2015-07-16 | Rgenix, Inc. | Lxr agonists and uses thereof |
| JP7025022B2 (ja) | 2016-01-11 | 2022-02-24 | ザ ロックフェラー ユニバーシティー | 骨髄系由来抑制細胞関連障害の治療のための方法 |
| JP2021504315A (ja) | 2017-11-21 | 2021-02-15 | ルジェニクス，インコーポレーテッド | 多形及びその使用 |
| US11174220B2 (en) | 2019-12-13 | 2021-11-16 | Inspirna, Inc. | Metal salts and uses thereof |
| US11753374B2 (en) * | 2020-11-18 | 2023-09-12 | Southern Reserach Institute | Compounds for the treatment of acute and chronic kidney disease |
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| HUP0103381A3 (en) | 1998-07-30 | 2002-07-29 | Japan Tobacco Inc | Disubstituted maleimide compounds and medicinal utilization thereof and the pharmaceutical compositions containing the same |
| ATE284387T1 (de) * | 1998-10-08 | 2004-12-15 | Smithkline Beecham Plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
| EP1212065A4 (en) | 1999-07-08 | 2004-02-11 | Tularik Inc | COMPILATIONS AND METHODS FOR INCREASING THE HDL CHOLESTEROL LEVEL |
| EP1224932A4 (en) | 1999-08-20 | 2002-10-16 | Sagami Chem Res | ACTIVE SUBSTANCES TO INHIBIT CELL DEATH |
| GB0008264D0 (en) | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
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2003
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2004
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- 2004-07-08 WO PCT/SE2004/001114 patent/WO2005005417A1/en not_active Ceased
- 2004-07-08 CN CNA2004800198411A patent/CN1823061A/zh active Pending
- 2004-07-08 MX MXPA06000414A patent/MXPA06000414A/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102419A patent/AR045721A1/es not_active Application Discontinuation
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- 2004-07-08 AU AU2004255999A patent/AU2004255999B2/en not_active Ceased
- 2004-07-08 KR KR1020067000712A patent/KR20060035748A/ko not_active Withdrawn
- 2004-07-08 JP JP2006520138A patent/JP2007521312A/ja not_active Withdrawn
- 2004-07-08 RU RU2006102130/04A patent/RU2006102130A/ru not_active Application Discontinuation
- 2004-07-08 DE DE602004014773T patent/DE602004014773D1/de not_active Expired - Fee Related
- 2004-07-08 EP EP04749150A patent/EP1646626B1/en not_active Expired - Lifetime
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- 2006-01-10 ZA ZA200600222A patent/ZA200600222B/en unknown
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Also Published As
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| KR20060035748A (ko) | 2006-04-26 |
| EP1646626A1 (en) | 2006-04-19 |
| HK1088320A1 (en) | 2006-11-03 |
| IL172760A0 (en) | 2006-04-10 |
| ATE399777T1 (de) | 2008-07-15 |
| DE602004014773D1 (de) | 2008-08-14 |
| CA2532056A1 (en) | 2005-01-20 |
| JP2007521312A (ja) | 2007-08-02 |
| EP1646626B1 (en) | 2008-07-02 |
| CN1823061A (zh) | 2006-08-23 |
| ZA200600222B (en) | 2007-04-25 |
| MY135821A (en) | 2008-07-31 |
| SA04250204B1 (ar) | 2008-03-23 |
| US20060235015A1 (en) | 2006-10-19 |
| TW200503691A (en) | 2005-02-01 |
| GB0316232D0 (en) | 2003-08-13 |
| AR045721A1 (es) | 2005-11-09 |
| BRPI0412472A (pt) | 2006-09-19 |
| UY28408A1 (es) | 2005-02-28 |
| IS8293A (is) | 2006-02-09 |
| AU2004255999A1 (en) | 2005-01-20 |
| AU2004255999B2 (en) | 2007-08-02 |
| MXPA06000414A (es) | 2006-03-17 |
| US7432288B2 (en) | 2008-10-07 |
| WO2005005417A1 (en) | 2005-01-20 |
| NO20060081L (no) | 2006-02-08 |
| RU2006102130A (ru) | 2007-08-20 |
| ES2308204T3 (es) | 2008-12-01 |
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