UA82108C2 - Производные пиррол-2,5-дитиона как модуляторы х-рецептора печени - Google Patents
Производные пиррол-2,5-дитиона как модуляторы х-рецептора печени Download PDFInfo
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- UA82108C2 UA82108C2 UAA200600270A UAA200600270A UA82108C2 UA 82108 C2 UA82108 C2 UA 82108C2 UA A200600270 A UAA200600270 A UA A200600270A UA A200600270 A UAA200600270 A UA A200600270A UA 82108 C2 UA82108 C2 UA 82108C2
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- Prior art keywords
- phenyl
- treatment
- amino
- compound
- methoxyphenyl
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- 102000004311 liver X receptors Human genes 0.000 title abstract 5
- 108090000865 liver X receptors Proteins 0.000 title abstract 5
- DVUZQONFTJKFPV-UHFFFAOYSA-N pyrrole-2,5-dithione Chemical class S=C1NC(=S)C=C1 DVUZQONFTJKFPV-UHFFFAOYSA-N 0.000 title description 2
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 68
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- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
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- 229960002651 trandolaprilat Drugs 0.000 description 1
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- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
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- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
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- 229950005973 zabiciprilat Drugs 0.000 description 1
- DFKDOZMCHOGOBR-UHFFFAOYSA-N zaragozic acid A Natural products O1C(C(O)(C(O2)C(O)=O)C(O)=O)(C(O)=O)C(OC(=O)C=CC(C)CC(C)CC)C(O)C21CCC(=C)C(OC(C)=O)C(C)CC1=CC=CC=C1 DFKDOZMCHOGOBR-UHFFFAOYSA-N 0.000 description 1
- DFKDOZMCHOGOBR-NCSQYGPNSA-N zaragozic acid A Chemical compound C([C@@H](C)[C@H](OC(C)=O)C(=C)CC[C@]12[C@H](O)[C@H]([C@](O2)(C(O)=O)[C@@](O)([C@H](O1)C(O)=O)C(O)=O)OC(=O)/C=C/[C@@H](C)C[C@@H](C)CC)C1=CC=CC=C1 DFKDOZMCHOGOBR-NCSQYGPNSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Заявленное изобретение касается некоторых новых замещенных соединений формулы І, способа получения таких соединений, их применения в модулировании рецепторов ядерных гормонов Х-рецептора печени (ХРП)(NR1H3) и/или(NR1H2), а также в лечении клинических состояний, включая сердечно-сосудистые болезни, такие как атеросклероз, воспалительные заболевания, болезнь Альцгеймера, липидные расстройства (дислипидемии), ассоциированные или не ассоциированные с резистентностью к инсулину, диабет типа 2 и другие проявления метаболического синдрома, способов их терапевтического применения и фармацевтических композиций, которые их содержат.
Applications Claiming Priority (2)
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| GBGB0316237.7A GB0316237D0 (en) | 2003-07-11 | 2003-07-11 | Therapeutic agents |
| PCT/SE2004/001115 WO2005005416A1 (en) | 2003-07-11 | 2004-07-08 | Pyrrole-2, 5-dithione derivatives as liver x receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82108C2 true UA82108C2 (ru) | 2008-03-11 |
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| UAA200600270A UA82108C2 (ru) | 2003-07-11 | 2004-08-07 | Производные пиррол-2,5-дитиона как модуляторы х-рецептора печени |
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| Country | Link |
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| US (1) | US20060189663A1 (ru) |
| EP (1) | EP1646625B1 (ru) |
| JP (1) | JP2007521313A (ru) |
| KR (1) | KR20060034284A (ru) |
| CN (1) | CN100478340C (ru) |
| AR (1) | AR045720A1 (ru) |
| AT (1) | ATE399776T1 (ru) |
| AU (1) | AU2004256000B2 (ru) |
| BR (1) | BRPI0412479A (ru) |
| CA (1) | CA2532068A1 (ru) |
| CO (1) | CO5640134A2 (ru) |
| DE (1) | DE602004014772D1 (ru) |
| ES (1) | ES2308205T3 (ru) |
| GB (1) | GB0316237D0 (ru) |
| IL (1) | IL172759A0 (ru) |
| IS (1) | IS8291A (ru) |
| MX (1) | MXPA06000447A (ru) |
| NO (1) | NO20060080L (ru) |
| RU (1) | RU2006102129A (ru) |
| SA (1) | SA04250203B1 (ru) |
| TW (1) | TW200507836A (ru) |
| UA (1) | UA82108C2 (ru) |
| UY (1) | UY28407A1 (ru) |
| WO (1) | WO2005005416A1 (ru) |
| ZA (1) | ZA200600229B (ru) |
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| SE0500058D0 (sv) * | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 5 |
| KR20070094963A (ko) | 2005-01-10 | 2007-09-27 | 아스트라제네카 아베 | 간 ｘ 수용체 조절제로서 이소티아졸-3(2ｈ)-온1,1-디옥사이드 유도체 |
| SE0500055D0 (sv) | 2005-01-10 | 2005-01-10 | Astrazeneca Ab | Therapeutic agents 3 |
| WO2007002654A2 (en) * | 2005-06-28 | 2007-01-04 | Daiichi Sankyo Company, Limited. | Lxr ligand testing method |
| CA2660963A1 (en) | 2006-08-21 | 2008-02-28 | Genentech, Inc. | Aza-benzothiophenyl compounds and methods of use |
| US10004703B2 (en) | 2006-10-12 | 2018-06-26 | Biogen Chesapeake Llc | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective CA++ activated ATP-sensitive cation channels regulated by SUR1 channels |
| WO2008046014A1 (en) | 2006-10-12 | 2008-04-17 | Remedy Pharmaceuticals, Inc. | Treatment of alzheimer's disease using compounds that reduce the activity of non-selective ca++- activated atp-sensitive cation channels regulated by sur1 receptors |
| US20100143270A1 (en) * | 2007-02-21 | 2010-06-10 | University Of Louisville Research Foubdation | Therapeutic cotinine compositions |
| PL2868315T3 (pl) * | 2007-12-04 | 2018-06-29 | Biogen Chesapeake Llc | Udoskonalone preparaty i sposoby liofilizacji oraz uzyskiwane liofilizaty |
| US20110034560A1 (en) * | 2008-01-29 | 2011-02-10 | Sven Jacobson | Liquid formulations of compounds active at sulfonylurea receptors |
| JP5615274B2 (ja) | 2008-07-01 | 2014-10-29 | ジェネンテック， インコーポレイテッド | Ｍｅｋキナーゼインヒビターとしてのイソインドロン誘導体及びその使用方法 |
| WO2010003025A1 (en) | 2008-07-01 | 2010-01-07 | Genentech, Inc. | Bicyclic heterocycles as mek kinase inhibitors |
| BR112013005425A2 (pt) | 2010-09-07 | 2018-05-02 | Snu R&Db Foundation | compostos sesterterpenos e suas utilizações |
| US10669296B2 (en) | 2014-01-10 | 2020-06-02 | Rgenix, Inc. | LXR agonists and uses thereof |
| AU2017207291B2 (en) | 2016-01-11 | 2023-06-15 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| AU2018373028A1 (en) | 2017-11-21 | 2020-04-30 | Inspirna, Inc. | Polymorphs and uses thereof |
| KR200492570Y1 (ko) | 2018-12-04 | 2020-11-05 | 박규환 | 조립식 계단장치를 위한 발판 |
| MX2022007164A (es) | 2019-12-13 | 2022-09-12 | Inspirna Inc | Sales metálicas y usos de estas. |
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| ATE284387T1 (de) * | 1998-10-08 | 2004-12-15 | Smithkline Beecham Plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
| JP2004500332A (ja) * | 1999-07-08 | 2004-01-08 | テュラリク インコーポレイテッド | Ｈｄｌコレステロール値を上昇させる組成物および方法 |
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2003
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- 2004-06-29 TW TW093119119A patent/TW200507836A/zh unknown
- 2004-07-05 SA SA4250203A patent/SA04250203B1/ar unknown
- 2004-07-08 CN CNB2004800197194A patent/CN100478340C/zh not_active Expired - Fee Related
- 2004-07-08 CA CA002532068A patent/CA2532068A1/en not_active Abandoned
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- 2004-07-08 RU RU2006102129/04A patent/RU2006102129A/ru not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| DE602004014772D1 (de) | 2008-08-14 |
| CA2532068A1 (en) | 2005-01-20 |
| RU2006102129A (ru) | 2006-08-27 |
| CN100478340C (zh) | 2009-04-15 |
| JP2007521313A (ja) | 2007-08-02 |
| NO20060080L (no) | 2006-02-08 |
| UY28407A1 (es) | 2005-02-28 |
| CO5640134A2 (es) | 2006-05-31 |
| AU2004256000B2 (en) | 2007-07-26 |
| BRPI0412479A (pt) | 2006-09-19 |
| EP1646625B1 (en) | 2008-07-02 |
| HK1088318A1 (en) | 2006-11-03 |
| AR045720A1 (es) | 2005-11-09 |
| SA04250203B1 (ar) | 2008-02-25 |
| WO2005005416A1 (en) | 2005-01-20 |
| GB0316237D0 (en) | 2003-08-13 |
| KR20060034284A (ko) | 2006-04-21 |
| EP1646625A1 (en) | 2006-04-19 |
| ATE399776T1 (de) | 2008-07-15 |
| IS8291A (is) | 2006-02-09 |
| AU2004256000A1 (en) | 2005-01-20 |
| US20060189663A1 (en) | 2006-08-24 |
| MXPA06000447A (es) | 2006-04-07 |
| ZA200600229B (en) | 2007-04-25 |
| IL172759A0 (en) | 2006-04-10 |
| TW200507836A (en) | 2005-03-01 |
| CN1820003A (zh) | 2006-08-16 |
| ES2308205T3 (es) | 2008-12-01 |
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