UA81790C2 - Замещенные пиролопиразольные производные как ингибиторы киназы - Google Patents
Замещенные пиролопиразольные производные как ингибиторы киназы Download PDFInfo
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- UA81790C2 UA81790C2 UAA200507098A UA2005007098A UA81790C2 UA 81790 C2 UA81790 C2 UA 81790C2 UA A200507098 A UAA200507098 A UA A200507098A UA 2005007098 A UA2005007098 A UA 2005007098A UA 81790 C2 UA81790 C2 UA 81790C2
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Landscapes
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Abstract
Данные соединения, представлены формулами (Іа) или (Іb), значения R и Rуказаны в описании изобретения, а также их фармацевтически приемлемые соли; данные соединения используются для лечения болезней, которые связаны с пролиферацией клеток, например, при лечении рака, вызванного измененной киназной активностью, которая зависит от клеточного цикла.
Applications Claiming Priority (2)
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| US43495202P | 2002-12-19 | 2002-12-19 | |
| PCT/EP2003/050942 WO2004056827A2 (en) | 2002-12-19 | 2003-12-04 | Substituted pyrrolo-pyrazole derivatives as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA81790C2 true UA81790C2 (ru) | 2008-02-11 |
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| UAA200507098A UA81790C2 (ru) | 2002-12-19 | 2003-04-12 | Замещенные пиролопиразольные производные как ингибиторы киназы |
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| EP (2) | EP2266987B1 (ru) |
| JP (2) | JP4739761B2 (ru) |
| KR (2) | KR101223826B1 (ru) |
| CN (1) | CN1726217B (ru) |
| AP (1) | AP2005003343A0 (ru) |
| AR (1) | AR042525A1 (ru) |
| AU (1) | AU2003300255B9 (ru) |
| BR (1) | BR0317455A (ru) |
| CA (1) | CA2508069C (ru) |
| CR (2) | CR7880A (ru) |
| CU (1) | CU23550B7 (ru) |
| EA (1) | EA010596B1 (ru) |
| EC (1) | ECSP055864A (ru) |
| ES (2) | ES2635191T3 (ru) |
| GE (1) | GEP20084435B (ru) |
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| ME (1) | MEP52408A (ru) |
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| MY (1) | MY141196A (ru) |
| NO (1) | NO333178B1 (ru) |
| NZ (1) | NZ540644A (ru) |
| OA (1) | OA13015A (ru) |
| PL (1) | PL377285A1 (ru) |
| RS (1) | RS20050462A (ru) |
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| TW (1) | TWI327470B (ru) |
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| ZA (1) | ZA200504298B (ru) |
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| BR0113176A (pt) * | 2000-08-10 | 2003-06-17 | Pharmacia Italia Spa | Compostos biciclo-pirazol, composições farmacêuticas compreendendo os compostos, uso dos compostos na fabricação de medicamentos, processos para a preparação dos compostos, coleção quìmica combinatória e métodos para o tratamento de mamìferos incluindo humanos utilizando os compostos |
| UA81790C2 (ru) | 2002-12-19 | 2008-02-11 | Фармация Италия С.П.А. | Замещенные пиролопиразольные производные как ингибиторы киназы |
| US7468376B2 (en) | 2003-02-27 | 2008-12-23 | Palau Pharma, S.A. | Pyrazolopyridine derivates |
| JP2006519816A (ja) * | 2003-03-11 | 2006-08-31 | ファルマシア・イタリア・ソシエタ・ペル・アツィオーニ | キナーゼ阻害剤として活性なビシクロピラゾール誘導体、それらの製造方法、及びそれらを含んでなる医薬組成物 |
| CA2539549A1 (en) | 2003-09-23 | 2005-04-07 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrrole derivatives as protein kinase inhibitors |
| US7572914B2 (en) | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CA2559285A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| WO2005089496A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| JP2007538004A (ja) * | 2004-03-18 | 2007-12-27 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | シヌクレイノパチーを治療する方法 |
| US7550598B2 (en) | 2004-08-18 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP2008523072A (ja) | 2004-12-07 | 2008-07-03 | ルーカス ファーマシューティカルズ， インコーポレイテッド | タンパク質キナーゼの阻害剤 |
| WO2006062982A2 (en) | 2004-12-07 | 2006-06-15 | Locus Pharmaceuticals, Inc. | Urea inhibitors of map kinases |
| BRPI0518509A2 (pt) * | 2005-01-10 | 2008-11-25 | Pfizer | pirrolopirazàis, inibidores de cinase potentes |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| NZ568692A (en) * | 2005-12-21 | 2011-07-29 | Pfizer Prod Inc | Carbonylamino pyrrolopyrazoles, potent kinase inhibitors |
| SI1979356T1 (sl) * | 2005-12-21 | 2013-11-29 | Pfizer Products Inc. | Karbonilamino pirolopirazoli, močni inhibitorji kinaze |
| ES2442491T3 (es) | 2006-03-03 | 2014-02-11 | Nerviano Medical Sciences S.R.L. | Biciclopirazoles activos como inhibidores de cinasa |
| BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
| ES2367416T3 (es) | 2006-10-11 | 2011-11-03 | Nerviano Medical Sciences S.R.L. | Derivados de pirrolo-pirazol sustituidos como inhibidores de quinasas. |
| UA96618C2 (en) * | 2007-02-07 | 2011-11-25 | Пфайзер Инк. | 3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors |
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