UA73004C2 - Біциклічні гетероцикли та лікувальний засіб на їх основі - Google Patents

Біциклічні гетероцикли та лікувальний засіб на їх основі

Info

Publication number: UA73004C2
Authority: UA; Ukraine
Prior art keywords: bicyclic heterocycles; plaj; translated; drug; relates
Prior art date: 2000-08-26

Application number

UA2003032533A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Франк Хіммельсбах

Франк Химмельсбах

Ельке Лангкопф

Эльке Лангкопф

Біргіт Юнг

Биргит Юнг

Штефан Блех

Флавіо Золка

Original Assignee

Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг

Берингер Ингельхайм Фарма Гмбх & Ко. Кг

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-26

Filing date

2001-08-18

Publication date

2005-05-16

2001-08-18 Application filed by Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг, Берингер Ингельхайм Фарма Гмбх & Ко. Кг filed Critical Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг

2005-05-16 Publication of UA73004C2 publication Critical patent/UA73004C2/uk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Oncology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

UA2003032533A 2000-08-26 2001-08-18 Біциклічні гетероцикли та лікувальний засіб на їх основі UA73004C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10042058A DE10042058A1 (de)	2000-08-26	2000-08-26	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP2001/009532 WO2002018351A1 (fr)	2000-08-26	2001-08-18	Heterocycles bicycliques, medicaments contenant lesdits composes, leur utilisation et procedes permettant de les produire

Publications (1)

Publication Number	Publication Date
UA73004C2 true UA73004C2 (uk)	2005-05-16

Family

ID=7653945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003032533A UA73004C2 (uk)	2000-08-26	2001-08-18	Біциклічні гетероцикли та лікувальний засіб на їх основі

Country Status (30)

Country	Link
EP (1)	EP1315705A1 (fr)
JP (1)	JP4834282B2 (fr)
KR (1)	KR100862873B1 (fr)
CN (1)	CN100404517C (fr)
AR (1)	AR033562A1 (fr)
AU (2)	AU8769401A (fr)
BG (1)	BG107559A (fr)
BR (1)	BR0113519A (fr)
CA (1)	CA2417897C (fr)
CZ (1)	CZ302567B6 (fr)
DE (1)	DE10042058A1 (fr)
EA (1)	EA005679B1 (fr)
EC (1)	ECSP034464A (fr)
EE (1)	EE05269B1 (fr)
HR (1)	HRP20030138A2 (fr)
HU (1)	HUP0300819A3 (fr)
IL (2)	IL154602A0 (fr)
ME (1)	MEP58708A (fr)
MX (1)	MXPA03001483A (fr)
MY (1)	MY126132A (fr)
NO (1)	NO324866B1 (fr)
NZ (1)	NZ524668A (fr)
PL (1)	PL360248A1 (fr)
RS (1)	RS52279B (fr)
SK (1)	SK287747B6 (fr)
TW (1)	TWI294422B (fr)
UA (1)	UA73004C2 (fr)
UY (1)	UY26903A1 (fr)
WO (1)	WO2002018351A1 (fr)
ZA (1)	ZA200300991B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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MEP45508A (en)	1999-06-21	2011-02-10	Boehringer Ingelheim Pharma	Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
DE10042059A1 (de) *	2000-08-26	2002-03-07	Boehringer Ingelheim Pharma	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7019012B2 (en)	2000-12-20	2006-03-28	Boehringer Ingelheim International Pharma Gmbh & Co. Kg	Quinazoline derivatives and pharmaceutical compositions containing them
TWI324597B (en) *	2002-03-28	2010-05-11	Astrazeneca Ab	Quinazoline derivatives
US6924285B2 (en)	2002-03-30	2005-08-02	Boehringer Ingelheim Pharma Gmbh & Co.	Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
RS85404A (sr) *	2002-03-30	2007-02-05	Boehringer Ingelheim Pharma Gmbh. & Co.Kg.,	4-(n-fenilamino)-kvinazolini/kvinolini kao inhibitori tirozin kinaza
DE10214412A1 (de) *	2002-03-30	2003-10-09	Boehringer Ingelheim Pharma	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
EP1521747B1 (fr)	2002-07-15	2018-09-05	Symphony Evolution, Inc.	Modulateurs de kinase de type recepteur et procedes d'utilisation
DE10326186A1 (de) *	2003-06-06	2004-12-23	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE10334226A1 (de) *	2003-07-28	2005-02-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
GB0317665D0 (en)	2003-07-29	2003-09-03	Astrazeneca Ab	Qinazoline derivatives
MXPA06002964A (es)	2003-09-16	2006-06-14	Astrazeneca Ab	Derivados de quinazolina como inhibidores de cinasa de tirosina.
JP4036885B2 (ja)	2003-09-19	2008-01-23	アストラゼネカアクチボラグ	キナゾリン誘導体
ES2925655T3 (es)	2003-09-26	2022-10-19	Exelixis Inc	Moduladores c-Met y métodos de uso
US7456189B2 (en)	2003-09-30	2008-11-25	Boehringer Ingelheim International Gmbh	Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE10345875A1 (de) *	2003-09-30	2005-04-21	Boehringer Ingelheim Pharma	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung
DE10350717A1 (de) *	2003-10-30	2005-06-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1856095B1 (fr)	2005-02-26	2011-08-24	AstraZeneca AB	Dérivés de quinazoline servant d'inhibiteurs de tyrosine kinase
KR100673775B1 (ko) *	2005-04-08	2007-01-24	엘지전자 주식회사	냉장고용 홈바
US20100234371A1 (en) *	2005-08-22	2010-09-16	Frank Himmelsbach	Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof
WO2007054550A1 (fr)	2005-11-11	2007-05-18	Boehringer Ingelheim International Gmbh	Derives de quinazoline pour le traitement des affections cancereuses
WO2007101782A1 (fr) *	2006-03-09	2007-09-13	Boehringer Ingelheim International Gmbh	Heterocycles bicycliques, medicaments contenant ces composes, leur utilisation et leur procede de fabrication
NZ576065A (en)	2006-09-18	2011-12-22	Boehringer Ingelheim Int	Method for treating cancer harboring egfr mutations
EP1921070A1 (fr)	2006-11-10	2008-05-14	Boehringer Ingelheim Pharma GmbH & Co. KG	heterocycles bicycliques, medicaments á base de ces composes, leur usage et procédé pour leur preparation
EP2118075A1 (fr)	2007-02-06	2009-11-18	Boehringer Ingelheim International GmbH	Hétérocycles bicycliques, agents pharmaceutiques contenant ces composés, leur utilisation et leur procédé de préparation
CN101939316B (zh)	2008-02-07	2013-10-02	贝林格尔.英格海姆国际有限公司	螺环杂环化合物、含有所述化合物的药物、其用途及其制备方法
BRPI0912170A2 (pt)	2008-05-13	2015-10-13	Astrazeneca Ab	composto, forma a, processo para a preparação da mesma, composição farmacêutica, uso de um composto, e, método para tratar um câncer em um animal de sangue quente
US8648191B2 (en)	2008-08-08	2014-02-11	Boehringer Ingelheim International Gmbh	Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
KR20250123237A (ko)	2009-01-16	2025-08-14	엑셀리시스, 인코포레이티드	암의 치료를 위한 ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
PT2451445T (pt)	2009-07-06	2019-07-10	Boehringer Ingelheim Int	Processo para secagem de bibw2992, dos seus sais e de formulações farmacêuticas sólidas compreendendo este ingrediente ativo
UA108618C2 (uk)	2009-08-07	2015-05-25		Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
KR101317809B1 (ko)	2011-06-07	2013-10-16	한미약품 주식회사	암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물
KR20140096571A (ko)	2013-01-28	2014-08-06	한미약품 주식회사	1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
CN105209456B (zh)	2013-03-06	2018-05-08	阿斯利康(瑞典)有限公司	表皮生长因子受体的活化突变形式的喹唑啉抑制剂
US9242965B2 (en)	2013-12-31	2016-01-26	Boehringer Ingelheim International Gmbh	Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
EP3126354B1 (fr) *	2014-04-04	2020-01-22	H. Lundbeck A/S	Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1
US20170176028A1 (en)	2015-12-18	2017-06-22	Lg Electronics Inc.	Air conditioner
US11446302B2 (en)	2016-11-17	2022-09-20	Board Of Regents, The University Of Texas System	Compounds with anti-tumor activity against cancer cells bearing EGFR or HER2 exon 20 mutations
CN112321814B (zh) *	2020-12-30	2021-03-23	广州初曲科技有限公司	一种吉非替尼艾地苯醌轭合物的制备及用途

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GB9508538D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
GB9624482D0 (en) *	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
AU719434B2 (en) *	1996-02-13	2000-05-11	Astrazeneca Ab	Quinazoline derivatives as VEGF inhibitors
GB9603095D0 (en) *	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline derivatives
ES2169355T3 (es) *	1996-03-05	2002-07-01	Astrazeneca Ab	Derivados de 4-anilinoquinazolina.
DE69710712T3 (de) *	1996-04-12	2010-12-23	Warner-Lambert Co. Llc	Umkehrbare inhibitoren von tyrosin kinasen
GB9718972D0 (en) *	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
DE19911509A1 (de) *	1999-03-15	2000-09-21	Boehringer Ingelheim Pharma	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

2000
- 2000-08-26 DE DE10042058A patent/DE10042058A1/de not_active Ceased
2001
- 2001-08-18 EA EA200300219A patent/EA005679B1/ru not_active IP Right Cessation
- 2001-08-18 CN CNB01814635XA patent/CN100404517C/zh not_active Expired - Fee Related
- 2001-08-18 IL IL15460201A patent/IL154602A0/xx unknown
- 2001-08-18 JP JP2002523469A patent/JP4834282B2/ja not_active Expired - Fee Related
- 2001-08-18 WO PCT/EP2001/009532 patent/WO2002018351A1/fr not_active Ceased
- 2001-08-18 BR BR0113519-8A patent/BR0113519A/pt not_active Application Discontinuation
- 2001-08-18 NZ NZ524668A patent/NZ524668A/en not_active IP Right Cessation
- 2001-08-18 PL PL36024801A patent/PL360248A1/xx not_active Application Discontinuation
- 2001-08-18 MX MXPA03001483A patent/MXPA03001483A/es active IP Right Grant
- 2001-08-18 EP EP01967285A patent/EP1315705A1/fr not_active Ceased
- 2001-08-18 UA UA2003032533A patent/UA73004C2/uk unknown
- 2001-08-18 AU AU8769401A patent/AU8769401A/xx active Pending
- 2001-08-18 ME MEP-587/08A patent/MEP58708A/xx unknown
- 2001-08-18 CZ CZ20030870A patent/CZ302567B6/cs not_active IP Right Cessation
- 2001-08-18 SK SK231-2003A patent/SK287747B6/sk not_active IP Right Cessation
- 2001-08-18 CA CA002417897A patent/CA2417897C/fr not_active Expired - Fee Related
- 2001-08-18 KR KR1020037002744A patent/KR100862873B1/ko not_active Expired - Fee Related
- 2001-08-18 HU HU0300819A patent/HUP0300819A3/hu unknown
- 2001-08-18 AU AU2001287694A patent/AU2001287694B2/en not_active Ceased
- 2001-08-18 HR HR20030138A patent/HRP20030138A2/hr not_active Application Discontinuation
- 2001-08-18 RS YU14003A patent/RS52279B/sr unknown
- 2001-08-18 EE EEP200300077A patent/EE05269B1/xx not_active IP Right Cessation
- 2001-08-23 UY UY26903A patent/UY26903A1/es not_active Application Discontinuation
- 2001-08-24 AR ARP010104041A patent/AR033562A1/es unknown
- 2001-08-24 MY MYPI20013985A patent/MY126132A/en unknown
- 2001-08-24 TW TW090120905A patent/TWI294422B/zh not_active IP Right Cessation
2003
- 2003-02-03 EC EC2003004464A patent/ECSP034464A/es unknown
- 2003-02-05 ZA ZA200300991A patent/ZA200300991B/en unknown
- 2003-02-14 BG BG107559A patent/BG107559A/bg unknown
- 2003-02-24 IL IL154602A patent/IL154602A/en not_active IP Right Cessation
- 2003-02-25 NO NO20030870A patent/NO324866B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL154602A0 (en)	2003-09-17
HK1057557A1 (zh)	2004-04-08
MEP58708A (en)	2011-05-10
IL154602A (en)	2008-07-08
NO20030870D0 (no)	2003-02-25
KR100862873B1 (ko)	2008-10-15
EP1315705A1 (fr)	2003-06-04
ECSP034464A (es)	2003-03-31
EA005679B1 (ru)	2005-04-28
DE10042058A1 (de)	2002-03-07
CZ302567B6 (cs)	2011-07-13
BG107559A (bg)	2003-10-31
NO20030870L (no)	2003-02-25
EE05269B1 (et)	2010-02-15
YU14003A (sh)	2006-01-16
RS52279B (sr)	2012-10-31
NZ524668A (en)	2006-06-30
EE200300077A (et)	2004-12-15
AU8769401A (en)	2002-03-13
NO324866B1 (no)	2007-12-17
TWI294422B (en)	2008-03-11
SK2312003A3 (en)	2003-10-07
MXPA03001483A (es)	2003-06-06
WO2002018351A1 (fr)	2002-03-07
EA200300219A1 (ru)	2003-08-28
HUP0300819A3 (en)	2008-03-28
JP4834282B2 (ja)	2011-12-14
UY26903A1 (es)	2002-03-22
KR20030024914A (ko)	2003-03-26
BR0113519A (pt)	2003-07-01
JP2004507529A (ja)	2004-03-11
CN1449390A (zh)	2003-10-15
CA2417897A1 (fr)	2003-01-30
MY126132A (en)	2006-09-29
ZA200300991B (en)	2004-04-16
AU2001287694B2 (en)	2007-09-06
HUP0300819A2 (hu)	2003-09-29
PL360248A1 (en)	2004-09-06
SK287747B6 (sk)	2011-08-04
AR033562A1 (es)	2003-12-26
HRP20030138A2 (en)	2005-04-30
CA2417897C (fr)	2009-03-31
CN100404517C (zh)	2008-07-23

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UA73004C2 (uk)	2005-05-16	Біциклічні гетероцикли та лікувальний засіб на їх основі
UY26902A1 (es)	2002-03-22	Heterocíclicos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación
CA2417652A1 (fr)	2003-01-28	Heterocycles bicycliques, compositions pharmaceutiques contenant ces composes, leur utilisation et procedes permettant de les produire
BG105893A (bg)	2002-05-31	Бициклени хетероцикли, фармацевтични състави, които ги съдържат и методи за тяхното получаване
BG105765A (bg)	2002-03-29	4-амино-хиназолинови и хинолинови производни с инхибиращо действие върху сигнална трансдукция, медиирана от тирозинкинази
YU90901A (sh)	2004-07-15	Biciklični heterocikli, lekovi koji sadrže ta jedinjenja, njihova primena i postupci za njihovo pripremanje
MEP59508A (en)	2011-05-10	Quinazoline derivatives, medicaments containing said compounds, their utilization and method for the production thereof
MY127771A (en)	2006-12-29	Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
CA2403152A1 (fr)	2001-10-18	Heterocycles bicycliques, compositions pharmaceutiques contenant ces composes, leur utilisation et leur procede de preparation
EA201001241A1 (ru)	2011-04-29	Спирогетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
CA2417050A1 (fr)	2002-03-07	Heterocycliques bicyclique, compositions pharmaceutiques contenant ces composes, leurs utilisations et procedes permettant de les produire
NO307833B1 (no)	2000-06-05	Pyrimido[5,4-d]pyrimidiner, fysiologisk aksepterbare salter, legemidler inneholdende disse forbindelser og deres anvendelse
TW200505912A (en)	2005-02-16	Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
UY27767A1 (es)	2003-11-28	Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo, y procedimientos para su preparación.
TW200510341A (en)	2005-03-16	Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
EA200901041A1 (ru)	2010-02-26	Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения
TW200730508A (en)	2007-08-16	Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same
WO2000055162A3 (fr)	2000-12-28	Heterocycles bicycliques, compositions pharmaceutiques contenant ces composes, utilisations et procedes de preparation de ces derniers
WO2007023073A3 (fr)	2007-05-18	Heterocycles bicycliques, produits pharmaceutiques contenant ces composes, leur utilisation et procede pour les preparer
YU60501A (sh)	2004-07-15	Derivati 4-amino-hinazolina i hinolina koji imaju inhibitorno dejstvo na prenos signala posredovanog tirozin kinazom
MY140484A (en)	2009-12-31	Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
CY1116921T1 (el)	2017-04-05	Δικυκλικες ετεροκυκλικες ενωσεις, φαρμακα που περιεχουν τις ενωσεις αυτες, χρηση αυτων και μεθοδος για την παραγωγη τους
UY26900A1 (es)	2002-03-22	Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación
UY26214A1 (es)	2001-01-31	Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación