UA63894C2 - 8-azabicyclo[3.2.1]oct-2-en derivatives, a method for the preparation thereof and a method for treatment (variants) - Google Patents
8-azabicyclo[3.2.1]oct-2-en derivatives, a method for the preparation thereof and a method for treatment (variants) Download PDFInfo
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- UA63894C2 UA63894C2 UA98031543A UA98031543A UA63894C2 UA 63894 C2 UA63894 C2 UA 63894C2 UA 98031543 A UA98031543 A UA 98031543A UA 98031543 A UA98031543 A UA 98031543A UA 63894 C2 UA63894 C2 UA 63894C2
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- azabicyclo
- ene
- compound according
- methyl
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- 238000000034 method Methods 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title description 12
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 title 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/04—Anorexiants; Antiobesity agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK115695 | 1995-10-13 | ||
| PCT/EP1996/004449 WO1997013770A1 (en) | 1995-10-13 | 1996-10-11 | 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA63894C2 true UA63894C2 (en) | 2004-02-16 |
Family
ID=8101642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA98031543A UA63894C2 (en) | 1995-10-13 | 1996-11-10 | 8-azabicyclo[3.2.1]oct-2-en derivatives, a method for the preparation thereof and a method for treatment (variants) |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6100275A (xx) |
| EP (1) | EP0859777B1 (xx) |
| JP (1) | JP3462505B2 (xx) |
| KR (1) | KR100274829B1 (xx) |
| CN (1) | CN1083840C (xx) |
| AT (1) | ATE362931T1 (xx) |
| AU (1) | AU709327B2 (xx) |
| BR (1) | BR9610960A (xx) |
| CA (1) | CA2233541C (xx) |
| CZ (1) | CZ285093B6 (xx) |
| DE (1) | DE69637097T2 (xx) |
| DK (1) | DK0859777T3 (xx) |
| EE (1) | EE03446B1 (xx) |
| HU (1) | HUP9802433A3 (xx) |
| IL (1) | IL123583A (xx) |
| IS (1) | IS4681A (xx) |
| NO (1) | NO980919L (xx) |
| NZ (1) | NZ320216A (xx) |
| PL (1) | PL185357B1 (xx) |
| RU (1) | RU2157372C2 (xx) |
| SK (1) | SK283425B6 (xx) |
| TR (1) | TR199800628T2 (xx) |
| UA (1) | UA63894C2 (xx) |
| WO (1) | WO1997013770A1 (xx) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
| CZ287821B6 (en) * | 1996-05-13 | 2001-02-14 | Zeneca Ltd | Bicyclic amines, process of their preparation and insecticidal, acaricidal and nematocidal agent containing thereof |
| GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
| GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
| NZ335422A (en) | 1996-11-26 | 2000-10-27 | Zeneca Ltd | 8-azabicyclo[3.2.1]octane-, 8-azabicyclo [3.2.1] oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives for use in insecticides |
| GB9624611D0 (en) | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
| GB9706222D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Bicyclic amine derivatives |
| CN1157392C (zh) * | 1997-05-30 | 2004-07-14 | 神经研究公司 | 在尼古丁ach受体上作为胆碱能配体的8-氮杂双环(3,2,1)辛-2-烯以及辛烷衍生物 |
| GB9726033D0 (en) | 1997-12-09 | 1998-02-04 | Zeneca Ltd | Chemical process |
| TWI221842B (en) | 1997-12-11 | 2004-10-11 | Syngenta Ltd | Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives |
| AU2609999A (en) * | 1998-01-28 | 1999-08-16 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form |
| US6403605B1 (en) * | 1998-05-29 | 2002-06-11 | Queen's University At Kingston | Methods for the normalization of sexual response and amelioration of long term genital tissue degradation |
| CA2335336A1 (en) * | 1998-06-19 | 1999-12-23 | James Edmund Audia | Inhibition of serotonin reuptake |
| EP1382605A3 (en) | 1998-11-27 | 2004-09-15 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives and their use as nAChR ligands |
| RU2211216C2 (ru) * | 1998-12-22 | 2003-08-27 | Мерк Патент Гмбх | Производные амидов и мочевины в качестве ингибиторов вторичного поглощения 5-ht и лигандов 5-ht1b/1d |
| DE60007841T2 (de) * | 1999-01-28 | 2004-07-08 | Neurosearch A/S | Neue azabicyclo derivate und ihre verwendung |
| ATE301636T1 (de) * | 1999-03-01 | 2005-08-15 | Pfizer | 1, 2, 3, 4-tetrahydro-1-naphthalenamin verbindungen zur therapeutsichen verwendung |
| DE60026146T2 (de) | 1999-09-03 | 2006-08-17 | Apbi Holdings, Llc | Verwendung von Dapoxetin, A selektiver Serotonin Aufnahme Inhibitor mit schnellem Wirkungseintritt, zur Behandlung von sexueller Disfunktion |
| WO2001046186A1 (en) * | 1999-12-20 | 2001-06-28 | Eli Lilly And Company | Benzofuran derivatives |
| US6852721B2 (en) | 2000-05-25 | 2005-02-08 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6667314B2 (en) | 2000-05-26 | 2003-12-23 | Pfizer, Inc. | Tropane derivatives useful in therapy |
| US6579878B1 (en) | 2000-07-07 | 2003-06-17 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| ES2269467T3 (es) * | 2000-10-13 | 2007-04-01 | Neurosearch A/S | Tratamiento de transtornos afectivos por la accion combinada de un agonista del receptor nicotinico y una sustancia monoaminergenica. |
| EP1379269B1 (en) | 2001-04-09 | 2009-03-04 | Neurosearch A/S | Adenosine a2a receptor antagonists combined with neurotrophic activity compounds in the treatment of parkinson's disease |
| TW589312B (en) | 2001-05-25 | 2004-06-01 | Wyeth Corp | Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression |
| RU2203044C1 (ru) * | 2001-12-27 | 2003-04-27 | Закрытое акционерное общество "Брынцалов-А" | Антидепрессант амитриптилин-ферейн |
| JP2005524712A (ja) | 2002-05-07 | 2005-08-18 | ニューロサーチ、アクティーゼルスカブ | 新規アザシクロエチニル誘導体 |
| US7407970B2 (en) * | 2003-06-24 | 2008-08-05 | Neurosearch A/S | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN101023081A (zh) * | 2004-09-30 | 2007-08-22 | 神经研究公司 | 新颖的色烯－2－酮衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
| JP2008534653A (ja) * | 2005-04-08 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 |
| TW200744590A (en) * | 2005-09-01 | 2007-12-16 | Neurosearch As | Novel compounds |
| RU2315047C1 (ru) * | 2006-09-04 | 2008-01-20 | Институт нефтехимии и катализа РАН | Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана |
| KR100812499B1 (ko) * | 2006-10-16 | 2008-03-11 | 이도훈 | 항경련제 |
| TWI415850B (zh) * | 2007-07-20 | 2013-11-21 | Theravance Inc | 製備ｍｕ類鴉片受體拮抗劑之中間物的方法 |
| WO2009109518A1 (en) * | 2008-03-05 | 2009-09-11 | Neurosearch A/S | Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB247886A (en) * | 1925-11-02 | 1926-02-25 | Thomas Stewart Hamilton | Improvements in attachments for leaf springs |
| US3133073A (en) | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
| US3657257A (en) * | 1970-08-31 | 1972-04-18 | Robins Co Inc A H | 3-aryl-8-carbamoyl nortropanes |
| US4180669A (en) * | 1976-12-13 | 1979-12-25 | Abbott Laboratories | 2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol |
| US4132710A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| GR70277B (xx) * | 1979-02-22 | 1982-09-03 | Wellcome Found | |
| US5418240A (en) * | 1990-08-21 | 1995-05-23 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| DK198590D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| GB9019973D0 (en) * | 1990-09-12 | 1990-10-24 | Wyeth John & Brother Ltd | Azabicyclic derivatives |
| NZ241481A (en) * | 1991-02-04 | 1994-06-27 | Hoechst Roussel Pharma | Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| DE4200145A1 (de) * | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
| WO1994026274A1 (en) * | 1993-05-18 | 1994-11-24 | Wake Forest University | Treatment process with biologically active tropane derivatives |
| NZ284075A (en) * | 1994-04-19 | 1998-01-26 | Neurosearch As | Tropane-2-aldoxine derivatives; neurotransmitter re-uptake inhibiting medicaments |
| US5731317A (en) * | 1995-03-10 | 1998-03-24 | Merck & Co., Inc. | Bridged piperidines promote release of growth hormone |
-
1996
- 1996-10-11 BR BR9610960A patent/BR9610960A/pt not_active Application Discontinuation
- 1996-10-11 HU HU9802433A patent/HUP9802433A3/hu unknown
- 1996-10-11 NZ NZ320216A patent/NZ320216A/xx not_active IP Right Cessation
- 1996-10-11 KR KR1019980702103A patent/KR100274829B1/ko not_active Expired - Fee Related
- 1996-10-11 AT AT96934662T patent/ATE362931T1/de active
- 1996-10-11 TR TR1998/00628T patent/TR199800628T2/xx unknown
- 1996-10-11 IL IL12358396A patent/IL123583A/xx not_active IP Right Cessation
- 1996-10-11 CN CN96197566A patent/CN1083840C/zh not_active Expired - Fee Related
- 1996-10-11 PL PL96326195A patent/PL185357B1/pl not_active IP Right Cessation
- 1996-10-11 WO PCT/EP1996/004449 patent/WO1997013770A1/en not_active Ceased
- 1996-10-11 EE EE9800062A patent/EE03446B1/xx not_active IP Right Cessation
- 1996-10-11 RU RU98105169/04A patent/RU2157372C2/ru not_active IP Right Cessation
- 1996-10-11 EP EP96934662A patent/EP0859777B1/en not_active Expired - Lifetime
- 1996-10-11 DK DK96934662T patent/DK0859777T3/da active
- 1996-10-11 CZ CZ98758A patent/CZ285093B6/cs not_active IP Right Cessation
- 1996-10-11 US US09/043,294 patent/US6100275A/en not_active Expired - Fee Related
- 1996-10-11 DE DE69637097T patent/DE69637097T2/de not_active Expired - Lifetime
- 1996-10-11 AU AU72917/96A patent/AU709327B2/en not_active Ceased
- 1996-10-11 CA CA002233541A patent/CA2233541C/en not_active Expired - Fee Related
- 1996-10-11 JP JP51472697A patent/JP3462505B2/ja not_active Expired - Fee Related
- 1996-10-11 SK SK287-98A patent/SK283425B6/sk unknown
- 1996-11-10 UA UA98031543A patent/UA63894C2/uk unknown
-
1998
- 1998-03-03 NO NO19980919A patent/NO980919L/no not_active Application Discontinuation
- 1998-03-04 IS IS4681A patent/IS4681A/is unknown
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