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UA5571A1 - СПОСІБ ОДЕРЖАННЯ 2-БРОМ-alРha-ЕРГОКРІПТІНУ АБО ЙОГО КИСЛОТНО-АДІТИВНИХ СОЛЕЙ - Google Patents

СПОСІБ ОДЕРЖАННЯ 2-БРОМ-alРha-ЕРГОКРІПТІНУ АБО ЙОГО КИСЛОТНО-АДІТИВНИХ СОЛЕЙ

Info

Publication number
UA5571A1
UA5571A1 UA4202820A UA4202820A UA5571A1 UA 5571 A1 UA5571 A1 UA 5571A1 UA 4202820 A UA4202820 A UA 4202820A UA 4202820 A UA4202820 A UA 4202820A UA 5571 A1 UA5571 A1 UA 5571A1
Authority
UA
Ukraine
Prior art keywords
acid
bromo
preparation
additive salts
ergocryptin
Prior art date
Application number
UA4202820A
Other languages
English (en)
Russian (ru)
Inventor
Медьєрі Габор
Медьери Габор
Кєва Тибор
Кева Тибор
Ковач Лайош
Штефко Бела
Богш Ерік
Богш Эрик
Колошаі Ана
Колошаи Анна
Тришлер Ференц
Сепеші Габор
Сепеши Габор
Газдаг Марія
Газдаг Мария
Original Assignee
Ріхтер Гедеон Ведьєсеті Д'Яр Рт
Рихтер Гедеон Ведьесети Дьяр РТ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ріхтер Гедеон Ведьєсеті Д'Яр Рт, Рихтер Гедеон Ведьесети Дьяр РТ filed Critical Ріхтер Гедеон Ведьєсеті Д'Яр Рт
Publication of UA5571A1 publication Critical patent/UA5571A1/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Спосіб одержання 2-бром-а-ергокриптину формули або його кислотно-адитивних солей з а-ергокриптину здійснюють шляхом його бромування. Бромуванню піддають а-ергокриптин або суміш основ, що містять поряд з а-ергокриптином такі ерготалкалоїди, як а-ергокриптинін, ергоїн, ергозинін або їх кислотно-адитивні солі. Процес здійснюють за допомогою системи, що складається з диметилсульфоксиду й триметилбромсилану при кімнатній температурі. Одержаний цільовий продукт за необхідності хроматографічно відокремлюють від супутніх 2-бром-ерготалкалоїдів або за необхідності переводять у кислотно-адитивну сіль.
UA4202820A 1986-06-27 1987-06-26 СПОСІБ ОДЕРЖАННЯ 2-БРОМ-alРha-ЕРГОКРІПТІНУ АБО ЙОГО КИСЛОТНО-АДІТИВНИХ СОЛЕЙ UA5571A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862690A HU196394B (en) 1986-06-27 1986-06-27 Process for preparing 2-halogenated ergoline derivatives

Publications (1)

Publication Number Publication Date
UA5571A1 true UA5571A1 (uk) 1994-12-28

Family

ID=10960659

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4202820A UA5571A1 (uk) 1986-06-27 1987-06-26 СПОСІБ ОДЕРЖАННЯ 2-БРОМ-alРha-ЕРГОКРІПТІНУ АБО ЙОГО КИСЛОТНО-АДІТИВНИХ СОЛЕЙ

Country Status (19)

Country Link
US (1) US4816587A (uk)
EP (1) EP0251732B1 (uk)
JP (1) JPH085879B2 (uk)
AR (1) AR243194A1 (uk)
AT (1) ATE88705T1 (uk)
AU (1) AU597673B2 (uk)
BG (1) BG48811A3 (uk)
CA (1) CA1301163C (uk)
CS (1) CS264295B2 (uk)
DD (1) DD264430A5 (uk)
DE (1) DE3785613T2 (uk)
DK (1) DK328687A (uk)
ES (1) ES2054672T3 (uk)
FI (1) FI89048C (uk)
HU (1) HU196394B (uk)
PL (1) PL151562B1 (uk)
SU (1) SU1528320A3 (uk)
UA (1) UA5571A1 (uk)
YU (1) YU46557B (uk)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
WO1994016094A2 (en) * 1993-01-12 1994-07-21 Biogen, Inc. Recombinant anti-vla4 antibody molecules
US20030157642A1 (en) * 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US6521421B1 (en) * 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6316241B1 (en) * 1997-11-20 2001-11-13 Genencor International, Inc. Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) * 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
US20050176629A1 (en) * 2001-03-13 2005-08-11 Andrews William H. Telomerase expression repressor proteins and methods of using the same
ATE495751T1 (de) 2001-03-15 2011-02-15 Neogenix Oncology Inc Behandlung von bauchspeicheldrüsenkrebs mit einem monoklonalen antikörper
US7338813B2 (en) 2001-07-02 2008-03-04 Sekisui Chemical Co., Ltd. Carrier particle latex for assay reagent and assay reagent
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
RU2274640C1 (ru) * 2004-09-15 2006-04-20 Всероссийский научно-исследовательский институт лекарственных и ароматических растений ("ВИЛАР") СПОСОБ БРОМИРОВАНИЯ α И β-ЭРГОКРИПТИНОВ
DK3202789T3 (da) 2010-04-16 2020-05-18 Biogen Ma Inc Anti-vla-4-antistoffer
KR101889111B1 (ko) 2010-06-11 2018-08-16 바스프 에스이 유기 첨가제를 포함하는 레이저-투명 ｐｂｔ
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
CN105560244B (zh) * 2014-10-10 2019-01-11 上海交通大学 一种γ-分泌酶抑制剂及其应用
US10160799B2 (en) 2014-11-19 2018-12-25 Axon Neuroscience Se Humanized tau antibodies in a alzheimer's disease
CN109313187B (zh) 2016-06-14 2022-05-06 电化株式会社 液体试样检测试剂盒用膜载体、液体试样检测试剂盒和液体试样检测试剂盒的制造方法
CN110312934B (zh) 2017-03-28 2023-02-17 电化株式会社 膜载体和使用其的液体试样检测试剂盒
WO2018181549A1 (ja) 2017-03-28 2018-10-04 デンカ株式会社 膜担体、並びにそれを用いた液体試料検査キット及びその製造方法
KR102848349B1 (ko) 2018-06-04 2025-08-21 바이오젠 엠에이 인코포레이티드 감소된 효과기 기능을 갖는 항-ｖｌａ-4 항체
KR20250028260A (ko) * 2022-05-12 2025-02-28 더 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 리세르그산 유도체 및 방법
WO2024145546A1 (en) * 2022-12-31 2024-07-04 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Also Published As

Publication number Publication date
YU46557B (sh) 1993-11-16
HUT44541A (en) 1988-03-28
ATE88705T1 (de) 1993-05-15
JPS6314783A (ja) 1988-01-21
FI89048C (fi) 1993-08-10
JPH085879B2 (ja) 1996-01-24
CS479187A2 (en) 1988-09-16
FI89048B (fi) 1993-04-30
SU1528320A3 (ru) 1989-12-07
CS264295B2 (en) 1989-06-13
DD264430A5 (de) 1989-02-01
ES2054672T3 (es) 1994-08-16
FI872852L (fi) 1987-12-28
HU196394B (en) 1988-11-28
EP0251732B1 (en) 1993-04-28
EP0251732A3 (en) 1989-05-10
AU597673B2 (en) 1990-06-07
PL266477A1 (en) 1988-07-21
FI872852A0 (fi) 1987-06-26
EP0251732A2 (en) 1988-01-07
PL151562B1 (en) 1990-09-28
DK328687D0 (da) 1987-06-26
US4816587A (en) 1989-03-28
YU119987A (en) 1988-06-30
DK328687A (da) 1987-12-28
AU7476387A (en) 1988-01-07
DE3785613T2 (de) 1993-08-12
AR243194A1 (es) 1993-07-30
CA1301163C (en) 1992-05-19
BG48811A3 (bg) 1991-05-15
DE3785613D1 (de) 1993-06-03

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