[go: up one dir, main page]

UA42719C2 - Сполуки, композиції та способи, які інгібують протеази, для лікування та профілактики імуномедіаторних запальних хвороб - Google Patents

Сполуки, композиції та способи, які інгібують протеази, для лікування та профілактики імуномедіаторних запальних хвороб

Info

Publication number
UA42719C2
UA42719C2 UA95104466A UA95104466A UA42719C2 UA 42719 C2 UA42719 C2 UA 42719C2 UA 95104466 A UA95104466 A UA 95104466A UA 95104466 A UA95104466 A UA 95104466A UA 42719 C2 UA42719 C2 UA 42719C2
Authority
UA
Ukraine
Prior art keywords
treatment
compositions
methods
inflammatory disorders
immunomediated inflammatory
Prior art date
Application number
UA95104466A
Other languages
English (en)
Russian (ru)
Inventor
Керрі Спеар
Керри Спеар
Чарльз Джонсон
Хайнц Гшвенд
Original Assignee
Аксіз Фармасьютікелз, Інк
Аксиз Фармасьютикелз, Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аксіз Фармасьютікелз, Інк, Аксиз Фармасьютикелз, Инк filed Critical Аксіз Фармасьютікелз, Інк
Publication of UA42719C2 publication Critical patent/UA42719C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Даний винахід належить до сполук і способів запобігання й лікування імуномедіаторних запальних розладів, зокрема до запобігання й лікування запальних захворювань, пов'язаних з респіраторним трактом. Більш конкретно винахід стосується інгібіторів триптази. Пропонуються також фармацевтичні композиції, а також аерозольні пристрої для введення цих композицій інтраназально.
UA95104466A 1993-03-12 1994-03-11 Сполуки, композиції та способи, які інгібують протеази, для лікування та профілактики імуномедіаторних запальних хвороб UA42719C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3077093A 1993-03-12 1993-03-12
US3118793A 1993-03-12 1993-03-12
PCT/US1994/002706 WO1994020527A1 (en) 1993-03-12 1994-03-11 Compositions and methods for the treatment of immunomediated inflammatory disorders

Publications (1)

Publication Number Publication Date
UA42719C2 true UA42719C2 (uk) 2001-11-15

Family

ID=26706445

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95104466A UA42719C2 (uk) 1993-03-12 1994-03-11 Сполуки, композиції та способи, які інгібують протеази, для лікування та профілактики імуномедіаторних запальних хвороб

Country Status (11)

Country Link
EP (1) EP0688337A1 (uk)
JP (1) JPH08507768A (uk)
KR (1) KR100309616B1 (uk)
CN (2) CN1057772C (uk)
AU (1) AU683459B2 (uk)
CZ (1) CZ289930B6 (uk)
FI (1) FI954245L (uk)
PL (1) PL176941B1 (uk)
SK (1) SK282537B6 (uk)
UA (1) UA42719C2 (uk)
WO (1) WO1994020527A1 (uk)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE189211T1 (de) * 1994-06-01 2000-02-15 Axys Pharm Inc Zusammensetzungen und verfahren zur behandlung von durch mast-zellen verursachten krankheiten
HUT77770A (hu) * 1994-09-23 1998-08-28 Axys Pharmaceuticals, Inc. Készítmény és eljárás hízósejtek által közvetített gyulladásos állapotok kezelésére
US6388122B1 (en) 1996-04-10 2002-05-14 Ono Pharmaceutical Co., Ltd. Tryptase inhibitor and novel guanidino derivatives
FI990171A7 (fi) * 1996-07-30 1999-03-23 Arris Pharm Corp Uusia yhdisteitä ja koostumuksia tryptaasiaktiivisuuden liittyvien tau tien hoitamiseksi
US5968782A (en) * 1996-12-04 1999-10-19 Brigham And Womens's Hospital, Inc. Mast cell protease that cleaves fibrinogen
US5955431A (en) * 1997-02-05 1999-09-21 Brigham And Women's Hospital, Inc. Mast cell protease peptide inhibitors
AU1208999A (en) * 1997-11-10 1999-05-31 Array Biopharma, Inc. Compounds which inhibit tryptase activity
US6221914B1 (en) * 1997-11-10 2001-04-24 Array Biopharma Inc. Sulfonamide bridging compounds that inhibit tryptase activity
AU1176299A (en) * 1997-11-26 1999-06-15 Yoshitomi Pharmaceutical Industries, Ltd. Tryptase inhibitors comprising heterocyclic amide compounds
SE515982C2 (sv) * 1998-03-06 2001-11-05 Lipocore Holding Ab Användning av en olja-i-vatten emulsion som bärare för framställning av en topikal kräm eller lotion
SE9800729L (sv) * 1998-03-06 1999-09-07 Scotia Lipidteknik Ab Ny topikal formulering I
DE19939910A1 (de) * 1999-08-23 2001-03-01 Morphochem Ag Neue Verbindungen, die Tryptase-Aktivität hemmen
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201863A (en) * 1974-11-08 1980-05-06 Mitsubishi Chemical Industries, Limited N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides

Also Published As

Publication number Publication date
SK282537B6 (sk) 2002-10-08
CN1057772C (zh) 2000-10-25
CZ232195A3 (en) 1996-07-17
CZ289930B6 (cs) 2002-04-17
KR100309616B1 (ko) 2002-02-28
FI954245A7 (fi) 1995-09-28
EP0688337A1 (en) 1995-12-27
FI954245L (fi) 1995-09-28
CN1234229A (zh) 1999-11-10
SK112995A3 (en) 1996-10-02
AU683459B2 (en) 1997-11-13
JPH08507768A (ja) 1996-08-20
CN1119019A (zh) 1996-03-20
FI954245A0 (fi) 1995-09-11
AU6364794A (en) 1994-09-26
PL310559A1 (en) 1995-12-27
PL176941B1 (pl) 1999-08-31
WO1994020527A1 (en) 1994-09-15

Similar Documents

Publication Publication Date Title
AU2002225772A1 (en) Therapeutic agents and methods of use thereof for treating an amyloidogenic disease
MX9604378A (es) Amidas de acido quinolin-2-carboxilico sustituidas, su preparacion y su empleo como medicamentos, asi como productos intermedios.
PL360495A1 (en) Arylmethylamine derivatives for use as tryptase inhibitors
BG101118A (en) Therapeutical compounds
YU71901A (sh) NOVE VRSTE LEKOVITIH KOMPOZICIJA NA BAZI JEDINJENJA KOJA DELUJU ANTIHOLINERGIJSKI I beta-MIMETIKA
DK0644932T3 (da) Oprensede former af DNase
TW262461B (uk)
EA200300776A1 (ru) Производные фенэтаноламина для лечения респираторных заболеваний
ATE334668T1 (de) Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
ATE320800T1 (de) Synergistische kombination von roflumilast und salmeterol
NO20050851L (no) Kaspase-inhibitorer og anvendelser derav
PT705100E (pt) Guanidinas substituidas terapeuticas
ATE402176T1 (de) Pyrrolidin- und azetidinverbindungen alsccr5- antagonisten
MEP54608A (en) Arylmethylamine derivatives for use as tryptase inhibitors
LV12291A (lv) Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
UA42719C2 (uk) Сполуки, композиції та способи, які інгібують протеази, для лікування та профілактики імуномедіаторних запальних хвороб
GB0130677D0 (en) Medicaments and novel compounds
DK1032556T3 (da) Farmaceutisk aktive forbindelser og anvendelsesfremgangsmåder
MX9403088A (es) Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
DE69928806D1 (de) (-)-pseudoephedrin als sympathomimetisches arzneimittel
DE60026491D1 (de) Melagatran zur behandlung von entzündungen
ZA979647B (en) Heterocyclic compounds, compositions and uses.
IL168308A (en) Compositions containing roflumilast and formoterol
ZA979650B (en) Heterocyclic compounds, compositions and uses.
ZA979645B (en) Heterocyclic compounds, compositions and uses.