099年12月21日按正替換頁 五、新型說明： 【新型所屬之技術領域】 _]本創作是有關於—種裝置，特別是有關於—種檢測唾液 中酒精濃度之裝置 【先前技術】 [〇〇〇2]近幾年來，政府及社會對於酒後駕車之行為曰益重視。 根據統計資料顯示，酒駕案件不僅佔了死亡交通事故的 30%左右，平均每年更發生了約14, 〇〇〇件，造成8〇〇多 人死亡。因此，酒駕一直都是交通安全宣導的重點。常 有民眾适為喝一點酒不會造成危險，覺得自己意識清醒 可以開車，竟輕易地在酒後開車上路，.因而發生很多交 通死亡事故的悲劇。 [0003] 快速篩選出那些酒後駕車或在高危險性環境下酒後作業 的人是非常必要的。人的身體素質參差不齊，對酒精的 反應也有差異，其它因素如飲食習慣、活動量大小也會 影響人體中酒精的濃度。換而言之，酒精對人的影響因 人而異’但酒精濃度達到一定水平後就會大大影響人的 自控能力。 [0004] 因此，酒後駕車永遠是危險的，許多國家（如日本）已採 取零容忍態度’只要駕駛員體内含有酒精，不管濃度高 低就屬於酒精影響下的危險開車。市面上酒精呼氣測試 儀之設計是以燈色的重鉻酸根離子氧化呼氣中的乙醇， 使顏色變化為綠色的鉻離子，再用比色法轉換成酒精的 度數。然而’傳統酒精呼氣測試儀具有靈敏度不高之缺 表單编號A0101 第3頁/共15頁 M399322 099年12月21日核正替换頁 點，其所計算出的酒精度數與體内血液中之酒精濃度差 異甚大。 【新型内容】 [0005] 有鑑於上述習知技藝之問題，本創作之目的就是在提供 一種檢測唾液中酒精濃度之裝置，以解決傳統酒精呼氣 測試儀靈敏度低、及其所計算出之酒精度數無法等同於 體内酒精濃度之問題。 [0006] 根據本創作之目的，提出一種檢測唾液中酒精濃度之裝 置，其包含酒精檢測試片及檢測儀。酒精檢測試片包含 β :第一絕緣基板、電極系統二反專層界夢,二絕緣基板。 '.二， 電極系統設置於第一絕緣基一表病^且^:極系統至 少包含一工作電極及一參考賴^三每#基板具有一 開口，且設置於電極系統上。反應層設置於電極系統之 表面上，並對應於且第二絕緣基板之開口。反應層具有 酒精氧化酶（alcohol oxidase)及電子媒介物，酒精氧 化酶係與唾液中之酒精作用，使產生一過氧化氫。 [0007] 此外，檢測儀包含殼體、訊號感測單元、處理單元及顯 示單元。殼體具有一插口，酒精檢測試片係插設於其插 ^ 口。訊號感測單元與處理單元皆設置於殼體内，並電性 連接於插口，以擷取電子媒介物與過氧化氫所產生的一 還原電流。處理單元電性連接訊號感測單元，以量測還 原電流，以得到唾液中之一酒精濃度。顯示單元設置於 殼體之一側，並電性連接處理單元，以顯示酒精濃度。 [0008] 其中，電極系統更可包括一輔助電極。 表單編號A0101 第4頁/共15頁 099年12月21日核正替換頁 _]其巾’檢㈣更可包括i存單元，係電性連接處理單 元，藉以健存酒精濃度及其相對應之測試日期與時間。 此外，檢測儀更可包括一輸出埠，以將儲存於儲存單元 之酒精濃度及其相對應之測試日期與時間輸出至一電子 裝置。 [_其中，檢測儀更可包括-供電單元，係設置於殼體相對 於顯不單元之一側内，以提供檢測酒精濃度時之電力。 [0011] 其中，第一絕緣基板或第二絕緣基板可包括聚乙烯對苯 二甲酸板（polyethylene terephthalate)、玻璃板、 聚碳酯板、玻璃纖維板（FR-4)聚酯楓板（p〇iyester • ·' suphone) ° [0012] 其中，電極系統之材質可包含碳、銅、銀、金、铑、釕 、錳、白金、鎳、鈷、鈀或其合金》 [0013] 其中’電子媒介物可包括麥爾多拉藍（Mel do la blue)、 普魯士藍（Prussian blue)、二氣酚鼓基紛 (dichlorophenol indophenol)、對笨二銅 . (p-benzoquinone)、鄰苯二胺 (o-phenylenediamine)、3,4:|^*Ta^ (3, 4-dihydroxy benzaldehyde)或其混合物。 [0014] 其中，顯示單元可包括發光二極體（LED)螢幕或有機發光 二極體（0LED)螢幕。 [0015] 承上所述，依本創作之檢測唾液中酒精濃度之裝置可具 有一或多個下述優點： 表單編號A0101 第5頁/共15頁 M399322 [0016] [0017] [0018] [0019] 099年12月21日修正替换頁 ⑴使㈣㈣於糊作之裝置，因錢中的酒精濃度 與血液中的酒精濃度幾乎相近，故本創作之裝置更為準 確地檢測人體内酒精的含量。 (2)本創作之裝置具有高靈敏度及特異性，對飲酒者進 行現場快速、方便的定性與定量檢測。 【實施方式】 以下將參照相關圖式，說明依本創作之檢測唾液中酒精 濃度之裝置之實施例，為使便於理解，下述實施例中之 相同元件係以相同之符號標示來說明。 請參閱第1圖及第2圖’其分激^^^本；灘作，之裝置中的酒 精檢測試片之一實施例之分卞,細作^裝置中的 檢測儀之一實例之方塊圖。本ϋ作.之私·.測唾液中酒精 濃度之裝置係包含酒精檢測試片1及檢測儀2。酒精檢測 ^片1包含第一絕緣基板11、電極系統12、反應層13及第 二絕緣基板14。電極系統12設皇於第一絕緣基板11之一 表面’且電極系統12至少包含工作電極121及參考電極 12 2。第二絕緣基板14具有一開口 141，且設置於電極系 統12上。反應層13设置於電極系統之表面上，且對應於 第二絕緣基板14之開口 141 (即反應層13大小相等於開 口 141大小）。反應層13具有酒精氧化酶（a 1 coho 1 〇χi-dase)及電子媒介物。 此外，檢測儀2包含殼體21、訊號感測單元22、處理單元 23及顯示單元24。殼體21具有一插口 211，此插口 211係 用以接受酒精檢測試片1。訊號感測單元22、與處理•單元 表單編號A0101 第6頁/共15頁 [0020] M399322December 21, 099, according to the replacement page 5, the new description: [New technical field] _] This creation is about a device, especially related to the detection of alcohol concentration in saliva [prior art] [〇〇〇2] In recent years, the government and society have paid attention to the behavior of drunk driving. According to statistics, the drunk driving case not only accounts for about 30% of death traffic accidents, but also an average of about 14 accidents per year, causing more than 8 deaths. Therefore, drunk driving has always been the focus of traffic safety. There are often people who drink a little wine and don't pose a danger. They feel that they are conscious and can drive, and they can easily drive on the road after drinking. So many tragedies of traffic accidents have occurred. [0003] It is necessary to quickly screen out those who drink or drive or work in a high-risk environment. People's physical fitness is uneven, and their responses to alcohol are also different. Other factors such as eating habits and the amount of activity also affect the concentration of alcohol in the human body. In other words, the effect of alcohol on people varies from person to person. However, when the alcohol concentration reaches a certain level, it will greatly affect people's self-control ability. [0004] Therefore, drunk driving is always dangerous. Many countries (such as Japan) have adopted a zero-tolerance attitude. As long as the driver's body contains alcohol, regardless of the high concentration, it is a dangerous driving under the influence of alcohol. The commercial alcohol breath tester is designed to oxidize the ethanol in the breath by the dichromate ion of the lamp color, change the color to the green chromium ion, and convert it to the degree of alcohol by colorimetry. However, the 'traditional alcohol breath tester has a low sensitivity. Form No. A0101 Page 3 / Total 15 pages M399322 December 21, 2010, the replacement page point, the calculated alcohol degree and blood in the body The alcohol concentration varies greatly. [New Content] [0005] In view of the above-mentioned problems of the prior art, the purpose of the present invention is to provide a device for detecting the alcohol concentration in saliva to solve the low sensitivity of the conventional alcohol breath tester and the calculated alcohol thereof. The degree cannot be equated with the problem of alcohol concentration in the body. [0006] According to the purpose of the present invention, a device for detecting the concentration of alcohol in saliva is proposed, which comprises an alcohol test strip and a detector. The alcohol test piece contains β: the first insulating substrate, the electrode system, the anti-layer layer dream, and the second insulating substrate. In the second, the electrode system is disposed on the first insulating substrate, and the electrode system includes at least one working electrode and a reference substrate. The substrate has an opening and is disposed on the electrode system. The reaction layer is disposed on the surface of the electrode system and corresponds to the opening of the second insulating substrate. The reaction layer has alcohol oxidase and an electron carrier, and the alcohol oxidase acts on the alcohol in the saliva to produce a hydrogen peroxide. Further, the detector includes a housing, a signal sensing unit, a processing unit, and a display unit. The housing has a socket, and the alcohol detecting test piece is inserted into the socket. The signal sensing unit and the processing unit are disposed in the housing and electrically connected to the socket to capture a reducing current generated by the electronic medium and hydrogen peroxide. The processing unit is electrically connected to the signal sensing unit to measure the return current to obtain an alcohol concentration in the saliva. The display unit is disposed on one side of the housing and electrically connected to the processing unit to display the alcohol concentration. [0008] wherein the electrode system further includes an auxiliary electrode. Form No. A0101 Page 4 / Total 15 pages December 21, 099 Nuclear replacement page _] Its towel 'check (4) can also include i storage unit, is the electrical connection processing unit, by which the concentration of alcohol and its corresponding Test date and time. In addition, the detector may further include an output port for outputting the alcohol concentration stored in the storage unit and its corresponding test date and time to an electronic device. [_] The detector may further include a power supply unit disposed in a side of the housing relative to the display unit to provide power for detecting the alcohol concentration. [0011] wherein, the first insulating substrate or the second insulating substrate may comprise polyethylene terephthalate, glass plate, polycarbonate plate, glass fiber board (FR-4) polyester maple (p〇 Iyester • · ' suphone) ° [0012] wherein the material of the electrode system may comprise carbon, copper, silver, gold, ruthenium, osmium, manganese, platinum, nickel, cobalt, palladium or alloys thereof [0013] wherein 'electronic medium The materials may include Mel do la blue, Prussian blue, dichlorophenol indophenol, p-benzoquinone, o-phenylenediamine (o). -phenylenediamine), 3,4:|^*Ta^ (3, 4-dihydroxy benzaldehyde) or a mixture thereof. [0014] wherein the display unit may comprise a light emitting diode (LED) screen or an organic light emitting diode (OLED) screen. [0015] As described above, the apparatus for detecting the concentration of alcohol in saliva according to the present invention may have one or more of the following advantages: Form No. A0101 Page 5 of 15 M399322 [0016] [0018] [0018] 0019] On December 21, 099, the replacement page (1) made (4) (4) the device for paste, because the alcohol concentration in the money is almost similar to the alcohol concentration in the blood, so the device of the creation more accurately detects the alcohol content in the human body. . (2) The device of this creation has high sensitivity and specificity, and it can quickly and conveniently determine the qualitative and quantitative detection of the drinker. [Embodiment] Hereinafter, embodiments of the apparatus for detecting the concentration of alcohol in saliva according to the present invention will be described with reference to the related drawings. For the sake of easy understanding, the same elements in the following embodiments are denoted by the same reference numerals. Please refer to Fig. 1 and Fig. 2 for the example of one of the alcohol test strips in the device, and the block diagram of one of the detectors in the device. . The device for measuring the concentration of alcohol in saliva comprises an alcohol test strip 1 and a detector 2. The alcohol detecting sheet 1 includes a first insulating substrate 11, an electrode system 12, a reaction layer 13, and a second insulating substrate 14. The electrode system 12 is provided on the surface of one of the first insulating substrates 11 and the electrode system 12 includes at least the working electrode 121 and the reference electrode 12 2 . The second insulating substrate 14 has an opening 141 and is disposed on the electrode system 12. The reaction layer 13 is disposed on the surface of the electrode system and corresponds to the opening 141 of the second insulating substrate 14 (i.e., the size of the reaction layer 13 is equal to the size of the opening 141). The reaction layer 13 has an alcohol oxidase (a 1 coho 1 〇χi-dase) and an electron vehicle. Further, the detector 2 includes a housing 21, a signal sensing unit 22, a processing unit 23, and a display unit 24. The housing 21 has a socket 211 for receiving the alcohol detecting test piece 1. Signal Sensing Unit 22, and Processing Units Form No. A0101 Page 6 of 15 [0020] M399322
Q99年:U月日孩正餘頁I 23皆設置於殼體21内，且訊號感測單元22與插口電性連 接。處理單元23則電性連接訊號感測單元22。顯示單元 24設置於殼體21之一側，並電性連接處理單元23，以顯 示酒精濃度。顯示單元24可為發光二極體aED)螢幕或有 機發光二極體（OLED)螢幕。 [0021] 4參閱第3圖’其係為本創作之檢測唾液中酒精濃度之裝 置之一實施例之示意圖。圖中，酒精檢測試片1係藉由檢 測儀2之插口2U。當唾液滴入酒精檢測試片丨之反應層^ 上。唾液中的酒精會與酒精氧化酶作用，使產生過氧化 氫。過氧化氫再與電子媒介物反應，並產生一還原電流 。當酒精檢測試片1以箭頭方向透過插口 211插入檢測儀2 中時’訊號感測單元22可播取電子媒介物與過氧化氫所 產生的還原電流。接續，訊號感測單元22將還原電流傳 輸至處理單元23 ’以量測還原電流，進而得到唾液令之 一酒精濃度。處理單元23在將已算出的酒精濃度傳輸至 顯示單元24，使其顯示於顯示單元24上。 [_此外，顯示單元24亦可顯示測量唾射酒精濃度的相對 應之測試曰期與時間’使得使用者更可記錄何時作酒精 檢測。因此，檢測儀2更可包括至少一按鈕25，其可調整 曰期、時間或任何酒精參數（基準值）。其中，於量測還 原電流之方法中，可利用將所量測之電流代入一預先以 酒精標準料與㈣電流所建立之雜方程式中，以決 定唾液中之酒精濃度（不以此為限）。 [_其中’上述的電㈣統12可更包括輔助電極（圖中未示） 表單編號A0101 ’使形成三極式電極。電極系統12之材質可包含碳、銅 第7頁/共15頁 銀、金、錢 電極系統12的選用並1白金、錦、始、城其合金。 氣化銀電極作从ΓΓ㈣，常見的選料使用銀/ 電極，輔助電極;==，工作電極121為一 材料可以與電子媒m«，上工作電極⑵的 、为自由搭配，惟必需注意電極盥豆 [0024] 微生物接觸可能發生的污染問題，造成訊號衰減r =閱㈣，其係為本創作之裝置中的 把例之方塊圊。m由A 行賞 2卜插口 2n 除了與第2圖所示之實施例之殼體 21㈣U、訊號感測單元22、處理單 =相同外，檢測儀2更可包括—儲存單元似―輪出早 ㈣,ΓΓ通用序列匯流排單元26 接處理單元23’而__轉师連接於 。時間’而輸料27則可㈣存於贿單元26 很度及其相對應之測試日期與時間輸出至—電子裝置 (例如電腦），以供使用者比較或列印其紀錄。 [0025] 。月參閱第5圖’其係為本創作之裝置中的檢測儀之另 !之不意圖。圖中’檢測儀2相對於顯示螢幕24之1 内八有供電早疋29，且於檢測儀2可具有一電源開關Μ 。供電單元29可用以提供檢測_濃度時所需之電力。 ;顯不勞幕上24亦可顯示供電單元29的電力狀況，例如 可顯示為一電池形狀。 其中，以上實施例之第—絕緣基板"或第二絕緣基 可匕括聚乙稀對笨二甲酸板（㈣㈣⑽咖kreph' 第8頁/共15頁 、玻璃板、聚碳酷板、玻桃維板（FR~4^ ^ ft -S/U ir [0026] 楓板（polyester suphone)，而電子媒介物則可包括麥 爾多拉藍（Meldola blue)、普魯士藍（prussiari blue)、二氣紛敏基盼（dichlorophenolindophenot) 、對苯二銅（p-benzoquinone)、鄰笨二胺 (o_phenyIenediamine)、3,4二Μ苯甲搭 (3’4-dihydroxy benzaldehyde)或其混合物，只要能 與過氧化氫產生還原電流即可。 [0027] 以上所述僅為舉例性，而非為限制性者。任何未脫離本 創作之精神與範疇’而對其進行之等效修改或變更，均 應包含於後附之申請專利範圍中。 【圖式簡單說明】 [0028] 第1圖其係為本創作之裝置中的酒精;^測試片之一實施例 之分解圖。 第2圖其係為本創作之裝置中的檢測儀之一實施例之方塊 圖。 第3圖其係為本創作之檢測唾液中酒精濃度之裝置之一實 施例之示意圖。 第4圖其係為本創作之裝置中的檢測儀之再一實施例之方 塊圖。 第5圖其係為本創作之裝置中的檢測儀之另一實施例之示 意圖。 【主要元件符號說明】 [0029] 1 :酒精檢測試片 11 :第一絕緣基板 12 :電極系統 表單编號A0101 第9頁/共15頁 M399322 121 :工作電極 122 :參考電極 '13 :反應層 14 :第二絕緣基板 141 :開口 2 :檢測儀 21 :殼體 211 :插口 2 2 :訊號感測單元 23 :處理單元 24 ··顯示單元 2 5 :按钮 26 :儲存單元 27 :輸出埠 28 :電源開關 29 :供電單元 3:電子裝置 099年12月21日修正替换頁In the case of the Q99 year: the U-day and the child's remaining pages I 23 are all disposed in the casing 21, and the signal sensing unit 22 is electrically connected to the socket. The processing unit 23 is electrically connected to the signal sensing unit 22. The display unit 24 is disposed on one side of the casing 21 and electrically connected to the processing unit 23 to display the alcohol concentration. Display unit 24 can be a light emitting diode (EDED) screen or an organic light emitting diode (OLED) screen. [0021] 4 See Fig. 3' is a schematic view showing an embodiment of the apparatus for detecting the concentration of alcohol in saliva. In the figure, the alcohol test piece 1 is passed through the socket 2U of the tester 2. When the saliva drops into the reaction layer of the alcohol test strip. Alcohol in saliva interacts with alcohol oxidase to produce hydrogen peroxide. Hydrogen peroxide then reacts with the electron mediator and produces a reduction current. When the alcohol detecting test piece 1 is inserted into the detector 2 through the socket 211 in the direction of the arrow, the signal sensing unit 22 can broadcast the reducing current generated by the electron mediator and hydrogen peroxide. In succession, the signal sensing unit 22 transmits the reduction current to the processing unit 23' to measure the reduction current, thereby obtaining a concentration of alcohol in the saliva. The processing unit 23 transmits the calculated alcohol concentration to the display unit 24 to display it on the display unit 24. [_ In addition, the display unit 24 can also display a corresponding test period and time for measuring the concentration of saliva alcohol so that the user can record when the alcohol is detected. Thus, the detector 2 may further comprise at least one button 25 which adjusts the flood time, time or any alcohol parameter (reference value). Wherein, in the method of measuring the reduction current, the measured current can be substituted into a mixed equation established by the alcohol standard material and the (IV) current to determine the alcohol concentration in the saliva (not limited thereto). . The above-mentioned electric (four) system 12 may further include an auxiliary electrode (not shown) of the form number A0101' to form a three-pole electrode. The material of the electrode system 12 can include carbon and copper. Page 7 / 15 pages Silver, gold, money Electrode system 12 is selected and 1 platinum, brocade, beginning, and city alloy. The vaporized silver electrode is made from ΓΓ (4), the common material is silver/electrode, auxiliary electrode; ==, the working electrode 121 is a material which can be freely matched with the electronic medium m«, the upper working electrode (2), but the electrode must be paid attention to. Kidney Bean [0024] The problem of contamination caused by microbial contact, resulting in signal attenuation r = read (4), which is the block of the example in the device of the creation. m is a row of 2 sockets 2n. In addition to the casing 21 (four) U, the signal sensing unit 22, and the processing order = the embodiment shown in FIG. 2, the detector 2 may further include a storage unit-like (4) The general-purpose serial bus unit 26 is connected to the processing unit 23' and the __ transfer is connected. The time of the delivery of 27 can be (4) deposited in the bribe unit 26 and its corresponding test date and time output to the electronic device (such as a computer) for the user to compare or print the record. [0025]. Please refer to Figure 5 for the month. It is not intended to be a detector in the device of the creation. In the figure, the detector 2 has a power supply earlier than the display screen 24, and the detector 2 can have a power switch Μ. The power supply unit 29 can be used to provide the power required to detect the concentration. The display 24 can also display the power status of the power supply unit 29, for example, as a battery shape. Wherein, the first-insulating substrate" or the second insulating base of the above embodiment may include a polyethylene-pure disinteate plate ((4)(4)(10) coffee kreph' page 8/15 pages, glass plate, polycarbon cool plate, glass Peach board (FR~4^^ ft -S/U ir [0026] maple suphone, while electronic media can include Meldola blue, prussiari blue, two Dichlorophenolindophenot, p-benzoquinone, o_phenyIenediamine, 3'4-dihydroxy benzaldehyde, or mixtures thereof, as long as Hydrogen peroxide can be used to generate a reduction current. [0027] The above description is intended to be illustrative only and not limiting, and any equivalent modifications or alterations thereof may be made without departing from the spirit and scope of the invention. It is included in the scope of the appended patent application. [Simplified illustration of the drawings] [0028] Fig. 1 is an exploded view of an embodiment of the test piece of alcohol; A block diagram of one embodiment of a detector in the device of the present invention. A schematic diagram of an embodiment of a device for detecting the concentration of alcohol in saliva. Figure 4 is a block diagram of still another embodiment of the detector in the device of the present invention. Figure 5 is a device of the present invention. Schematic diagram of another embodiment of the detector. [Description of main component symbols] [0029] 1 : Alcohol test strip 11 : First insulating substrate 12 : Electrode system form No. A0101 Page 9 / Total 15 pages M399322 121 : Working electrode 122: Reference electrode '13: Reaction layer 14: Second insulating substrate 141: Opening 2: Detector 21: Housing 211: Socket 2 2: Signal sensing unit 23: Processing unit 24 · Display unit 2 5 : Button 26: Storage unit 27: Output 埠 28: Power switch 29: Power supply unit 3: Electronic device December 21, 2017 Revision replacement page
表單編號A0101 第10頁/共15頁Form No. A0101 Page 10 of 15