TWI832471B - Free radical scavenging and pro-whitening polygonum capitatum microcapsule carrier and preparation method and use thereof - Google Patents

Abstract

Disclosed is a Polygonum capitatum microcapsule carrier which demonstrates free radical scavenging and pro-whitening effects. The carrier comprises a hydrophilic sphere structure having a water-soluble macromolecular polymer; a P. capitatum extract mosaicked or coated in the hydrophilic sphere structure; and an oily spherical shell structure encompassing the hydrophilic sphere structure and comprising an fat, wherein weight of the water-soluble macromolecular polymer is larger than that of the P. capitatum extract, and volume of the fat is larger than or equal to that of the water-soluble macromolecular polymer. Thereby, P. capitatum extract coated by the microcapsule carrier in the present invention can achieve skin-care effects. Meanwhile, product aesthetics is also enhanced when the P. capitatum extract is coated by the microcapsule carrier.

Description

Polygonum powder microcapsule carrier with free radical scavenging and whitening effects and its preparation Methods and uses

The present invention relates to a polygonum powder microcapsule carrier and its preparation method. In particular, it refers to a method of wrapping active ingredients in a carrier to maintain its efficacy and improve the color of the product. It particularly relates to free radical scavenging, antioxidant and whitening effects.

In recent years, the public is very fond of skin care products containing natural extracts. The types of such cosmetics are developing rapidly every year. However, adding natural extracts to cosmetics will not only easily cause the precipitation of natural extracts, but also cause the problem of natural substances. The problem of pigments affecting the appearance of products often causes the white appearance of the lotion to be affected by brown natural extracts, thus reducing the aesthetics of the product. Therefore, the industry can only add a very small amount of effective extracts, resulting in unsatisfactory skin care effects. In addition, some active ingredients are easily changed in properties due to exposure to ultraviolet rays, or are prone to oxidation reactions with oxygen, thereby reducing their efficacy.

According to the Chinese Patent Announcement No. CN102675298B, the patent name is "Method for extracting and preparing silymarin from the whole plant of Polygonum capitatum". It discloses a method for extracting and preparing silymarin from the whole plant of Polygonum capitatum (i.e., Polygonum nucifera). Specifically, first Petroleum ether is heated and refluxed for extraction, and the extract is discarded; then soaked in a high-concentration ethanol aqueous solution, followed by percolation or heated reflux extraction, and then concentrated under reduced pressure to obtain a fluid extract; finally, the fluid extract is obtained Add water to suspend and extract with ethyl acetate. After the extract is concentrated under reduced pressure and evaporated to dryness, silymarin powder is obtained by column chromatography.

Press, U.S. Patent Publication No. US20160367618A1, patent name "A KIND OF POLYGONUM CAPITATUM EXTRACT,ITS APPLICATION AND A PREPARATION CONTAINING THE POLYGONUM CAPITATUM EXTRACT", specifically discloses a preparation method of powdered polygonum extract, which includes: using dry powdered powder Polygonum is soaked in 55 to 65% ethanol, refluxed for extraction and then filtered and concentrated. Then the extracted residual substrate is boiled in water, filtered and concentrated. Finally, the alcohol extract and water extract are combined and concentrated.

The conventional technology can extract specific active ingredients from Polygonum spp., or extract the whole plant of Polygonum spp., and expect to extract most of the active ingredients. However, there is no guidance on the dosage form, storage, etc. of these active ingredients in subsequent applications. Propose substantial solutions; furthermore, the above-mentioned shortcomings of cosmetics containing natural products are still issues that need to be overcome in this field in order to improve the quality of the products and achieve better skin care effects.

Now, in view of the fact that the above-mentioned existing cosmetics containing natural ingredients still have many deficiencies in actual use, the inventor used his rich professional knowledge and years of practical experience to improve them, and based on this, he developed this invention. invention.

The main purpose of the present invention is to provide a method of encapsulating active ingredients in a functional microcapsule carrier to maintain its efficacy, and to improve the color of the final product. Therefore, the present invention provides a powdered polygonum microcapsule carrier that has the ability to scavenge free radicals. And whitening effect, including: a water-based spherical structure, which contains a water-soluble polymer; a powdered polygonum extract, which is embedded in the water-based spherical structure, or coated in the water-based spherical structure; and an oily spherical shell The structure covers the water-based spherical structure and includes a grease, wherein the weight of the water-soluble polymer is greater than the weight of the powdered polygonum extract, and the volume of the grease is greater than or equal to the water-soluble polymer.

The polygonum polygonum microcapsule carrier as described above, wherein the oil includes olive oil, camellia oil, sesame oil, flax oil, canola oil, soybean oil, peanut oil, corn germ oil, salad oil, palm oil, sunflower oil or fish oil .

The polygonum powder microcapsule carrier as described above, wherein the water-soluble polymer includes poloxamer 188, polyvinylpyrrolidone K30, polyvinylpyrrolidone VA64, HPC-L or HPC-SSL.

Polygonum microcapsule carrier as described above, wherein the preparation method of the Polygonum extract includes grinding the dried Polygonum whole plant into Polygonum powder, and soaking the Polygonum powder in an ethanol solution for extraction. A crude extract is obtained, and the crude extract is dried to obtain the polygonum polygonum extract.

The polygonum polygonum microcapsule carrier as described above, wherein the oily spherical shell structure further includes an antioxidant, which is a fat-soluble antioxidant including vitamin E, vitamin E derivatives, vitamin A or vitamin A derivatives.

Another object of the present invention is to provide a method for preparing a polygonum microcapsule carrier, which includes the following steps: (a) dissolving the water-soluble polymer in a polar solvent to obtain a first solution; (b) Add a polygonum powder extract to the first solution and mix evenly to form a first mixed liquid; (c) Add the first mixed liquid to another first solution, and heat to a first temperature and stir evenly To obtain a second mixed solution; (d) add a cross-linking agent to the second mixed solution and stir it at temperature to obtain a third mixed solution, which contains an aqueous spherical structure dispersed therein; (e) add the The third mixed solution is poured into a grease and stirred at a temperature to form an oily spherical shell structure on the aqueous spherical structure to obtain the powdery polygonum microcapsule carrier.

The method as described above, wherein the oil includes olive oil, tea oil, sesame oil, flax oil, canola oil, soybean oil, peanut oil, corn germ oil, salad oil, palm oil, sunflower oil or fish oil.

The method as described above, wherein the water-soluble polymer includes poloxamer 188, polyvinylpyrrolidone K30, polyvinylpyrrolidone VA64, HPC-L or HPC-SSL.

The method as mentioned above, wherein the preparation method of the Polygonum spp. extract includes grinding the dried Polygonum spp. whole plant into Polygonum spp. powder, and soaking the Polygonum spp. powder in an ethanol solution for extraction to obtain a crude extract, The crude extract was dried to obtain the Polygonum praecox extract.

The method as described above, wherein the oily spherical shell structure further includes an antioxidant, which is a fat-soluble antioxidant including vitamin E, vitamin E derivatives, vitamin A or vitamin A derivatives.

The method as described above, wherein the cross-linking agent includes saponin, sodium bicarbonate, sodium carbonate, sodium acetate, sodium oxalate or sodium lactate.

The method as mentioned above, wherein the cross-linking agent is carried by an aqueous carrier and added to the second mixed solution, wherein the aqueous carrier includes water, ethanol, propylene glycol, propanol, butanol or any two thereof. combination.

The method as mentioned above, wherein the fat is dissolved in an antioxidant system including vitamin E, vitamin E derivatives, vitamin A or vitamin A derivatives.

In one aspect, the present invention provides a use for preparing a free radical scavenging, antioxidant and whitening composition, which includes administering an effective dose of the composition to a desired individual, wherein the composition includes as described above Polygonum powder microcapsule carrier.

Therefore, in order to improve the shortcomings of natural product-containing cosmetics such as easy oxidation, difficulty in preservation, and deep color, the present invention uses a material to coat the functional ingredients of natural plant extracts to prepare a microcapsule carrier that coats the functional ingredients. When consumers use this product, they can Shear stress pushes out the functional ingredients wrapped inside the microcapsule carrier, so that the functional ingredients are released in a timely manner when used to achieve the highest skin care effect.

(Steps a to e)

Figure 1 is a flow chart of the preparation method of the polygonum polygonum microcapsule carrier provided by the present invention; Figures 2A to 2C are appearance diagrams of preferred embodiments of the polygonum polygonum microcapsule carrier provided by the present invention; Figures 3A to 3B are the appearance and color diagrams of the polygonum polygonum microcapsule carrier provided by the present invention; Figures 4A to 4B are the appearance color diagrams of the polygonum polygonum extract; Figure 5 is the appearance and color diagram of the polygonum polygonum microcapsule carrier provided by the present invention. Cytotoxicity analysis chart; Figure 6 is an analysis chart of the whitening efficacy of the polygonum polygonum extract and the polygonum polygonum microcapsule carrier provided by the present invention.

The purpose of the present invention and its structural and functional advantages will be explained based on the structure shown in the following figures and with specific embodiments, so that the review committee can have a deeper and more specific understanding of the present invention.

One embodiment of the present invention provides a polygonum polygonum microcapsule carrier, which has free radical scavenging and whitening effects, including: a water-based spherical structure containing a water-soluble polymer; a polygonum polygonum extract inlaid with on the water-based spherical structure, or coated in the water-based spherical structure; and an oily spherical shell structure covering the water-based spherical structure, which contains a grease, wherein the weight of the water-soluble polymer is greater than that of the powdered polygonum The weight of the extract and the volume of the oil are greater than or equal to the water-soluble polymer.

In some embodiments, the oil may include olive oil, tea oil, sesame oil, flax oil, canola oil, soybean oil, peanut oil, corn germ oil, salad oil, palm oil, sunflower oil or fish oil, or any two or more thereof. The combination is preferably olive oil.

In some embodiments, the water-soluble polymer can include poloxamer 188, polyvinylpyrrolidone K30, polyvinylpyrrolidone VA64, HPC-L or HPC-SSL.

In some embodiments, the preparation method of the Polygonum spp. extract includes grinding the dried Polygonum spp. whole plant into Polygonum spp. powder, soaking the Polygonum spp. powder in an ethanol solution and extracting it to obtain a crude extract, and drying the Polygonum spp. The crude extract is used to obtain the Polygonum lucidum extract; specifically, the weight ratio of the Polygonum lucidum powder and the ethanol solution is 1: (1 to 10), preferably 1: (3 to 7); the ethanol solution The ethanol solution is 60 to 95% and the polygonum powder is soaked for 1 to 5 days, preferably 75% or 95% and soaked for 3 days; the method of drying the crude extract is not limited to freeze drying and spraying Dry or hot air dry.

In some embodiments, the oily spherical shell structure further includes an antioxidant, which is a fat-soluble antioxidant including vitamin E, vitamin E derivatives, vitamin A or vitamin A derivatives.

Another embodiment of the present invention provides a method for preparing a polygonum microcapsule carrier. Refer to Figure 1, which includes the following steps: (a) dissolving the water-soluble polymer in a polar solvent to obtain a The first solution; (b) add a powdered polygonum extract to the first solution and mix evenly to form a first mixed solution; (c) add the first mixed solution to another first solution, and heat to a first temperature and stir evenly to obtain a second mixed solution; (d) add a cross-linking agent to the second mixed solution and stir at a constant temperature to obtain a third mixed solution containing aqueous spheres dispersed therein Structure; (e) Pour the third mixed solution into a grease and stir it at temperature to form an oily spherical shell structure on the aqueous spherical structure to obtain the powdery polygonum microcapsule carrier; specifically, the Most of the active ingredients of the Polygonum nucifera extract are polar components. The water-soluble polymer contacts and coats the polar groups, and is fixed with a cross-linking agent to preserve the active ingredients. It is then embedded or coated with oil. The water-soluble polymer of the polygonum polygonum extract is used to form the polygonum polygonum microcapsule carrier. The oily spherical shell structure composed of oil can protect the active ingredients enclosed in it from deterioration by natural factors such as sunlight and air oxidation.

In some embodiments, the oil may include olive oil, tea oil, sesame oil, flax oil, canola oil, soybean oil, peanut oil, corn germ oil, salad oil, palm oil, sunflower oil, fish oil, or any two thereof. A combination of the above.

In some embodiments, the water-soluble polymer can include poloxamer 188, polyvinylpyrrolidone K30, polyvinylpyrrolidone VA64, HPC-L or HPC-SSL.

In some embodiments, the cross-linking agent includes saponin, sodium bicarbonate, sodium carbonate, sodium acetate, sodium oxalate, or sodium lactate.

In some embodiments, the cross-linking agent is carried by an aqueous carrier and added to the second mixed solution, wherein the aqueous carrier includes water, ethanol, propylene glycol, propanol, butanol or a combination of any two thereof; Preferably, the weight percentage of the cross-linking agent in the aqueous carrier is 0.1 to 2.0% (w/w), more preferably 0.5 to 1.5%.

In some embodiments, the fat is dissolved in an antioxidant system including vitamin E, vitamin E derivatives, vitamin A or vitamin A derivatives.

In some embodiments, the first temperature is 60 to 85°C, and steps (c), (d), and (e) are stirred for 10 to 60 minutes respectively. Preferably, the first temperature is 70°C, and Steps (c), (d), and (e) are stirred for 20 to 45 minutes respectively.

The polygonum powder microcapsule carrier prepared by the method provided in this embodiment has a particle size of approximately 0.1 to 0.55 μm.

In various embodiments, in the step (b), the volume ratio of the first solution and the polygonum powder extract is (1 to 10):1; in the step (c), the first mixing The volume ratio of the third mixed solution to the other first solution is 1: (1 to 10); in step (e), the volume ratio of the third mixed solution to the grease is (1 to 10): 1.

In addition, the following several examples are used to further prove the scope of practical application of the present invention, but are not intended to limit the scope of protection of the present invention. All modifications and improvements based on the spirit of the present invention are within the scope of the present invention. Declaration of scope of protection.

Example 1: Preparation of Polygonum extract

Polygonum capitatum was sun-dried and ground into powder. The powder weighed 160 grams, and 80 grams of each was extracted with ethanol of different concentrations (95%, 75%).

(1) Extract with 75% ethanol: Extract with 640ml of 75% ethanol, let it stand for 1 or 3 days, then filter with filter paper, place the filtrate in a concentration bottle, further use a concentrator to concentrate to remove the solvent, repeat four times times, a concentrated extract was obtained, and then the extract was freeze-dried by a freeze dryer to obtain a total of 14.6 grams of Polygonum miltiorrhiza extract. The sample codes were A5-1 and A5-3.

(2) Extract with 95% ethanol: Extract with 640ml of 95% ethanol, let it stand for 1 or 3 days, then filter with filter paper, place the filtrate in a concentration bottle, further use a concentrator to concentrate to remove the solvent, repeat four times times, a concentrated extract was obtained, and then the extract was freeze-dried by a freeze dryer to obtain a total of 9.3 grams of Polygonum praecox extract. The sample codes were A6-1 and A6-3.

Example 2: Evaluating the antioxidant capacity of Polygonum nucifera extract

Using the polygonum powder extract of Example 1 to evaluate ABTS (2,2-Azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) free radical scavenging ability and DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging Determination of ability.

(1) The test results of ABTS removal by the Polygonum oleracea extract are shown in Table 1. The Polygonum oleracea extract extracted under different extraction conditions all have good antioxidant effects. Among them, A5-3 (extracted with 75% ethanol for 3 days) The best antioxidant effect.

(2) The test results of DPPH removal by Polygonum spp. extract are shown in Table 2. Among the Polygonum spp. extracts extracted under different extraction conditions, A5-3 (extracted with 75% ethanol for 3 days) has the best freedom of scavenging DPPH. Basic efficacy.

Table 2

Example Three: Preparation of Polygonum Polygonum Microcapsule Carrier

Functional microcapsule carriers were prepared with three different concentrations of cross-linking agents. In this example, the cross-linking agent was sodium bicarbonate (NaHCO ₃ ), and its contents were 0.5%, 1% and 1.5% respectively; in the preparation In the process of making the functional microcapsule carrier, the NaHCO ₃ content in the ingredients is changed, and a total of three different NaHCO ₃ contents are changed, which are NaHCO ₃ accounting for 0.5%, 1% and 1.5% of the total raw materials. The microcapsule material and The weight ratio of natural extracts is 1:40.

First prepare a polyvinylpyrrolidone (PVP) aqueous solution as A solution, mix the polygonum powder extract and A solution to form B solution; pour B solution into another A solution, heat to 70°C and stir for 30 minutes, then add NaHCO ₃ aqueous solution , maintain the temperature at 70°C and stir for 30 minutes, then add solution C, maintain the temperature at 70°C and stir for 20 to 45 minutes to obtain a polygonum microcapsule carrier, in which solution C contains vitamin E and olive oil.

The prepared polygonum polygonum microcapsules were observed in microscopic form using a transmission electron microscope (TEM). The results are shown in Figures 2A to 2C. The polygonum polygonum microcapsule carrier was spherical, and As the NaHCO ₃ content is different, the particle size distribution of the microcapsules is also different, and the results are shown in Table 3.

Extract the polygonum polygonum extract for 3 days with 95% ethanol and 75% ethanol respectively, and coat the extracted polygonum polygonum extract with a microcapsule carrier. The obtained polygonum polygonum microcapsule carrier is shown in Figures 3A to 3B As shown; please refer to Figure 3A. The color of the polygonum microcapsule carrier extracted with 95% ethanol is yellow-green. Compared with the dark brown color of the uncoated polygonum polygonum extract (as shown in Figure 4A), after being coated with the microcapsule carrier, the appearance and color have been specifically improved; in addition, please refer to Figure 3B to The color of the polygonum polygonum microcapsule carrier extracted with 75% ethanol is light yellow-green. Compared with the dark brown and green color of the uncoated polygonum polygonum extract (as shown in Figure 4B), after micro- After the capsule carrier is coated, specific improvements are also achieved in appearance and color. From the above, it can be seen that the content of the cross-linking agent has a specific impact on the particle size and stability of the functional microcapsule carrier, and improves the subsequent coating rate of the polygonum powder extract.

Example 4: Evaluating the cellular safety of polygonum polygonum microcapsule carrier

To evaluate the safety of the polygonum polygonum microcapsule carrier by detecting cytotoxicity, the cells were treated with 50, 100 and 200 μg/ml of the polygonum polygonum microcapsule carrier samples B1-1, B2-1 and B2-3 respectively. To evaluate the cellular safety of the polygonum polygonum microcapsule carrier, the control group was sterile pure water. The experimental results are shown in Figure 5. All samples were non-cytotoxic at each test concentration.

Example 5: Evaluating the whitening efficacy of Polygonum nucifera extract and Polygonum nucifera microcapsule carrier

To evaluate the effect of the polygonum polygonum extract on the melanin content of cells, the whitening efficacy was mainly evaluated by inhibiting melanoma cells in mice, and Kojic acid was used as the positive control group, and the control group was pure Water, among which the samples of "Polygonum Polygonum Extract" are A5-1, A5-3, A6-1 and A6-3, and the samples of "Polygonum Polygonum Microcapsule Carrier" are B1-1, B2-1 and B2- 3.

The results are shown in Figure 6. "Polygonum Polygonum Microcapsule Carrier" Sample B2-1 and "Polygonium Polygonum Extract" A5-3 have obvious inhibitory effects on melanin content. Therefore, Polygonum Polygonum Microcapsule Sample B2-1 and Both Polygonum Polygonum extracts A5-3 have whitening effects; in addition, the effect of "Polygonum Polygonum Microcapsule Carrier" B2-1 in inhibiting melanin content is better than that of Polygonum Polygonum Extract A5-3, showing that Polygonum Polygonum After the polygonum extract is coated with a carrier, the whitening effect is not reduced but increased.

Example 6: Evaluation of the antioxidant capacity of polygonum polygonum microcapsule carrier

The polygonum powder microcapsule carrier of Example 3 was tested for its ABTS (2,2-Azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) free radical scavenging ability and DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical The scavenging ability was measured and the results are shown in Table 4 and Table 5.

(1) The test results of the ABTS removal by the polygonum polygonum microcapsule carrier are shown in Table 4. The ABTS scavenging effect of the polygonum polygonum microcapsule carrier prepared with different cross-linking agent concentrations is better than that of the control group. Among them, B2-1 The sample (1% cross-linker) has the best removal effect.

(2) The test results of the polygonum polygonum microcapsule carrier for removing DPPH are shown in Table 5. The B2-1 sample prepared with 1% cross-linking agent performed the best in removing DPPH. The B2-3 and A5-1 samples were in the reaction. Precipitation occurs and interferes with its antioxidant effect.

From Example 6, it can be seen that the polygonum polygonum extract obtained by extraction in a short time (A5-1) not only reduces its antioxidant effect, but also affects the stability of the extract itself and is prone to precipitation; in addition, high-concentration cross-linking The polygonum microcapsule carrier formed by using the agent (1.5%) not only has a relatively uneven particle size distribution (0.13 to 0.44μm), but also exhibits poor stability, which is not conducive to back-end product applications.

Compared with the prior art, the present invention has the following advantages:

1. The present invention uses microcapsule carriers to coat the polygonum polygonum extract with free radical scavenging and whitening effects, which not only prevents the oxidation of the active ingredients, but also increases the whitening effect without reducing it, improves the color of the product, and enhances the overall beauty of the product. Sex and quality.

2. The microcapsule carrier preparation method provided by the present invention not only preserves the component activity of the polygonum powder extract, but also has stability and is not easy to precipitate, which is beneficial to back-end product applications.

3. The polygonum powder microcapsule carrier provided by the present invention can push out the functional ingredients coated inside the microcapsules through the shear stress of the application during use, so that the functional ingredients can be released in a timely manner during use. The shelf life of active ingredients is extended, and higher skin care effects can be expected.

In summary, the polygonum polygonum microcapsule carrier and its preparation method of the present invention can indeed achieve the expected use effects through the embodiments disclosed above, and the present invention has not been disclosed before the application. It has been completely completed. Comply with the provisions and requirements of the patent law. If you submit an application for an invention patent in accordance with the law, I sincerely request you to review it and grant a patent, which will be of great benefit.

However, the above-mentioned illustrations and descriptions are only preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Generally, those familiar with the art will make other decisions based on the characteristics and scope of the present invention. Equivalent changes or modifications should be considered as not departing from the design scope of the present invention.

Claims (9)

A Polygonum capitatum microcapsule carrier, which has free radical scavenging and whitening effects, including: a water-based sphere structure, which contains a water-soluble polymer; a Polygonum capitatum extract, which is coated on the water-based sphere In the structure, the preparation method of the Polygonum Polygonum extract includes: soaking a Polygonum Polygonum powder in an ethanol solution; and an oily spherical shell structure covering the water-based spherical structure, which includes a grease, wherein, the The weight of the water-soluble polymer is greater than the weight of the polygonum powder extract, and the volume of the oil is greater than or equal to the water-soluble polymer. The polygonum polygonum microcapsule carrier according to claim 1, wherein the oils and fats include olive oil, camellia oil, sesame oil, flax oil, canola oil, soybean oil, peanut oil, corn germ oil, salad oil, palm oil, and sunflower oil. oil or fish oil. The polygonum polygonum microcapsule carrier according to claim 1, wherein the water-soluble polymer includes poloxamer 188, polyvinylpyrrolidone K30, polyvinylpyrrolidone VA64, HPC-L or HPC-SSL. The polygonum polygonum microcapsule carrier according to claim 1, wherein the oily spherical shell structure further includes an antioxidant, which is a fat-soluble antioxidant including vitamin E, vitamin E derivatives, vitamin A or vitamin A derivatives. . The preparation method of the polygonum microcapsule carrier described in claim 3 includes the following steps: (a) dissolving the water-soluble polymer in a polar solvent to obtain a first solution; (b) dissolving the water-soluble polymer Add the polygonum powder extract to the first solution and mix evenly to form a first mixed liquid; (c) Add the first mixed solution to another first solution, and heat to a first temperature and stir evenly to obtain a second mixed solution, wherein the first temperature is 60 to 85°C; (d) in Add a cross-linking agent to the second mixed solution, and stir while maintaining the first temperature to obtain a third mixed solution, which contains an aqueous spherical structure dispersed therein; (e) pour the third mixed solution into the grease , and maintain the first temperature and stir to form an oily spherical shell structure on the aqueous spherical structure to obtain the powdery polygonum microcapsule carrier. The polygonum polygonum microcapsule carrier according to claim 5, wherein the cross-linking agent includes saponin, sodium bicarbonate, sodium carbonate, sodium acetate, sodium oxalate or sodium lactate. The polygonum polygonum microcapsule carrier according to claim 6, wherein the cross-linking agent is carried by an aqueous carrier and added to the second mixed solution, wherein the aqueous carrier includes water, ethanol, propylene glycol, propanol, Butanol or a combination of any two thereof. The polygonum polygonum microcapsule carrier according to claim 5, wherein the oil is dissolved in an antioxidant system including vitamin E, vitamin E derivatives, vitamin A or vitamin A derivatives. A method of preparing a free radical scavenging, antioxidant and whitening composition, which includes administering an effective dose of the composition to a desired individual, wherein the composition includes the powdered polygonum microorganism as described in claim 5 Capsule carrier.