TWI827173B - Specimen separation device - Google Patents

Abstract

A specimen separation device includes a shell and multiple separation units. The housing defines an accommodating space and a specimen input port connected to the accommodating space and facing upward. The separation units are spaced up and down in layers and are detachably provided on the housing, and each separation unit has a filter membrane located in the accommodation space. The filter membranes of the separation units have different pore sizes, and the filter membranes located lower from top to bottom have smaller pore sizes, so that the sample enters from the sample input port and passes through the sample input port sequentially from top to bottom. The components of different sizes in the sample are separated by the filter membrane of the separation unit.

Description

Specimen separation device

The present invention relates to a specimen separation device, and in particular, to a specimen separation device used to separate components of different sizes in biological specimens.

Generally, biological specimens need to be processed first after collection to separate the components to be analyzed from the specimen for subsequent related examinations.

How to simplify the procedure of separating specimens and reduce the contact opportunities between examiners and specimens to reduce the risk of biological infection is a problem to be solved.

Therefore, one object of the present invention is to provide a specimen separation device that can simplify the procedure of separating specimens.

Therefore, in some embodiments, the specimen separation device of the present invention includes: a housing and a plurality of separation units. The housing defines an accommodating space and a specimen input port connected to the accommodating space and facing upward. The separation units are spaced up and down in layers and are detachably provided on the housing, and each separation unit has a filter membrane located in the accommodation space. The filter membranes of the separation units have different pore sizes, and the filter membranes located lower from top to bottom have smaller pore sizes, so that the sample enters from the sample input port and passes through the sample input port sequentially from top to bottom. The components of different sizes in the sample are separated by the filter membrane of the separation unit.

In some implementations, the housing also defines an air extraction port connected to the accommodation space and located below the separation units, and the specimen separation device further includes an air extraction port connected to the air extraction port for extracting air from the accommodation space. Extraction unit.

In some embodiments, the specimen separation device further includes a collection box and a puncture unit. The collection box is detachably combined with the housing and has a surrounding wall that is accommodated in the specimen input port. , an upper cover covering the surrounding wall, and a sealing film closing the bottom of the surrounding wall. The sealing film and the surrounding wall jointly define a temporary storage space for accommodating the specimen, and the puncture unit is located on the surrounding wall. The housing is located at the specimen input port and includes a puncture tool for puncturing the sealing film.

In some embodiments, the puncture unit further includes a stirrer, which is used to cooperate with the puncture tool to stir the specimen after the puncture tool punctures the sealing film.

In some embodiments, the housing also defines an infusion port connected to the accommodation space and located above the separation units, and the specimen separation device further includes a sterilization unit connected to the infusion port for injecting disinfectant.

In some embodiments, the specimen separation device further includes a tray unit removably provided on the housing and located below the separation units for containing waste liquid.

In some embodiments, the filter membranes of the separation units are mainly made of chitin.

The present invention has the following effects: by using the separation units to separate components of different sizes in the specimen, the separation process can be completed at one time, simplifying the procedure of separating the specimen, and reducing the contact opportunities between the inspection personnel and the specimen, so as to Reduce the risk of biological infection. After the components of different sizes in the sample are separated, advanced analysis can be performed on the components of different sizes captured by different filter membranes.

Referring to Figures 1 and 2, one embodiment of the specimen separation device of the present invention includes a housing 1, a collection box 2, a puncture unit 3, a plurality of separation units 4, a tray unit 5, and an air extraction unit. 6 and a disinfection unit 7.

The housing 1 defines an accommodating space 11, a specimen input port 12 connected to the accommodating space 11 and upward, an air extraction port 13 connected to the accommodating space 11 and located below the separation units 4, and connected to the An infusion port 14 is located in the accommodation space 11 and above the separation units 4 .

The collection box 2 is detachably assembled with the housing 1 and has a surrounding wall 21 accommodated in the specimen input port 12, an upper cover 22 covering the surrounding wall 21, and closing the surrounding wall 21 The sealing film 23 at the bottom, the sealing film 23 and the surrounding wall 21 jointly define a temporary storage space 24 for accommodating the specimen.

The puncture unit 3 is provided in the housing 1 and located at the specimen input port 12, and includes a puncture device 31 for puncturing the sealing film 23, and a stirrer 32. The stirrer 32 is used to cooperate with the puncturer 31 to stir the specimen after the puncturer 31 punctures the sealing film 23 to evenly distribute the specimen. In this embodiment, the stirrer 32 uses rotatable blades for stirring. In alternative embodiments, a stirrer capable of generating airflow for stirring may also be used.

The separation units 4 are spaced up and down in layers and are detachably provided on the housing 1 . Each separation unit 4 has a frame 41 and a filter membrane 42 located in the accommodation space 11 . In this embodiment, each separation unit 4 is assembled with the housing 1 in a drawer-like manner, so that it can be easily installed in the housing 1 and taken out easily. The filter membranes 42 of the separation units 4 have different pore sizes, and the filter membrane 42 located lower from top to bottom has a smaller pore size, so that the sample enters from the sample input port 12 and moves from top to bottom. Components of different sizes in the specimen are separated sequentially through the filter membranes 42 of the separation units 4 . Specimens suitable for this embodiment may include sputum, feces, pleural hydrops, ascites, urine, bronchial washing fluid, etc. Depending on the needs of the specimen, appropriate preservation fluids and separation fluids can be added to the collection box 2, and then through these The separation unit 4 filters, whereby cells or specific biological proteins of different sizes and characteristics can be separated or retained on the filter membrane 42 for subsequent related specimen interpretation. The filter membrane 42 is preferably made of a material that can be dissolved in a specific solution. In this embodiment, the filter membrane 42 of the separation units 4 is mainly made of chitin (chitin+chitosan), which is decomposed in a specific acidic solution. Under this condition, it can be converted from solid to liquid, and acidic solution can be used as a disinfection method to improve the medical waste treatment process after collecting specimens.

The tray unit 5 is detachably provided on the housing 1 and is located below the separation units 4 for containing waste liquid. In this embodiment, the tray unit 5 is also assembled with the housing 1 in a drawer-like manner, so that the tray unit 5 containing the waste liquid can be easily taken out for processing the waste liquid.

The air extraction unit 6 is connected to the air extraction port 13 and used to evacuate air from the accommodation space 11 to form a vacuum state. By the air extraction unit 6 extracting air from below the separation units 4, an air flow flowing from top to bottom can be formed, which can accelerate the specimen to pass through the filter membranes 42 and control the air pressure in the accommodation space 11. At the same time, the filtration characteristics of the filter membranes 42 of different sizes allow the cells in the specimen to stay on the appropriate filter membrane 42 under appropriate pressure.

The disinfection unit 7 is connected to the infusion port 14 for injecting disinfectant to sterilize the separation units 4 .

In a modified embodiment, the collection box 2 and the puncture unit 3 may not be provided, and an outer cover (not shown) may be used to cover and seal the specimen input port 12 . The samples can be collected in a container, poured into the sample input port 12, and then filtered through the filter membranes 42, thereby achieving the purpose of separating the samples. In another modified embodiment, the puncture unit 3 may not be provided with the stirrer 32 but only be provided with the puncturer 31 .

In summary, by using the separation units 4 to separate components of different sizes in the specimen, the separation process can be completed at one time, which simplifies the process of separating the specimen and reduces the chance of contact between the inspection personnel and the specimen, so as to Reduce the risk of biological infection.

However, the above are only examples of the present invention, and should not be used to limit the scope of the present invention. All simple equivalent changes and modifications made based on the patent scope of the present invention and the content of the patent specification are still within the scope of the present invention. Within the scope covered by the patent of this invention.

1: Shell 11: Accommodation space 12: Specimen input port 13:Exhaust port 14:Infusion port 2: Collection box 21: around the wall 22: Upper cover 23:Sealing film 24:Temporary storage space 3: Puncture unit 31:Puncture device 32: Blender 4:Separation unit 41:frame 42:Filter membrane 5: Serving unit 6: Air extraction unit 7: Disinfection unit

Other features and effects of the present invention will be clearly presented in the embodiments with reference to the drawings, in which: Figure 1 is a schematic diagram of an embodiment of the specimen separation device of the present invention; and Figure 2 is a perspective view of a separation unit in this embodiment.

1: Shell

11: Accommodation space

12: Specimen input port

13:Exhaust port

14:Infusion port

2: Collection box

21: around the wall

22: Upper cover

23:Sealing film

24:Temporary storage space

3: Puncture unit

31:Puncture device

32: Blender

4:Separation unit

5: Serving unit

6: Air extraction unit

7: Disinfection unit

Claims (4)

A specimen separation device includes: a shell defining an accommodation space, a specimen input port connected to the accommodation space and facing upward, and an infusion port connected to the accommodation space; a collection box that can be disassembled and assembled It is combined with the shell and has a surrounding wall that is accommodated in the specimen input port, an upper cover that covers the surrounding wall, and a sealing film that seals the bottom of the surrounding wall. The sealing film and the surrounding wall jointly define a temporary storage space for accommodating specimens; a puncture unit, which is provided on the housing and located at the specimen input port, including a puncture tool for puncturing the sealing film, and a puncture unit for piercing the sealing film; The puncture tool is matched with a stirrer that stirs the specimen after the puncture tool punctures the sealing film; a plurality of separation units are spaced up and down in layers and are detachably provided on the housing, and each separation unit has a structure located at There is a filter membrane in the accommodation space. The filter membranes of the separation units have different pore sizes, and the filter membranes located lower from top to bottom have smaller pore sizes, so that the sample can pass through the sample input port. After entering, pass through the filter membranes of the separation units sequentially from top to bottom to separate the components of different sizes in the specimen; and a disinfection unit connected to the infusion port for injecting disinfectant, and the infusion port is located in the separation units. above the unit. The specimen separation device according to claim 1, wherein the housing further defines an air extraction port connected to the accommodation space and located below the separation units, and the specimen separation device further includes an air extraction port connected to the air extraction port for extracting air from the container. Set up an air extraction unit for space air extraction. The specimen separation device described in claim 1 further includes a device that is detachably mounted on the The outer casing is a tray unit located below the separation units to hold the waste liquid. The specimen separation device of claim 1, wherein the filter membranes of the separation units are mainly made of chitin.

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