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TWI800875B - 苯芴醇及其衍生物在治療冠狀病毒感染方面的應用 - Google Patents

苯芴醇及其衍生物在治療冠狀病毒感染方面的應用 Download PDF

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Publication number
TWI800875B
TWI800875B TW110126933A TW110126933A TWI800875B TW I800875 B TWI800875 B TW I800875B TW 110126933 A TW110126933 A TW 110126933A TW 110126933 A TW110126933 A TW 110126933A TW I800875 B TWI800875 B TW I800875B
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TW
Taiwan
Prior art keywords
lumefantrine
derivatives
treatment
application
coronavirus infection
Prior art date
Application number
TW110126933A
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English (en)
Other versions
TW202224673A (zh
Inventor
曹瑞源
王曼麗
李薇
趙磊
楊晶晶
李月香
樊士勇
周辛波
肖典
胡志紅
李松
鐘武
Original Assignee
中國人民解放軍軍事科學院軍事醫學研究院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 中國人民解放軍軍事科學院軍事醫學研究院 filed Critical 中國人民解放軍軍事科學院軍事醫學研究院
Publication of TW202224673A publication Critical patent/TW202224673A/zh
Application granted granted Critical
Publication of TWI800875B publication Critical patent/TWI800875B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW110126933A 2020-07-24 2021-07-22 苯芴醇及其衍生物在治療冠狀病毒感染方面的應用 TWI800875B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010722678.6 2020-07-24
CN202010722678.6A CN111686096B (zh) 2020-07-24 2020-07-24 苯芴醇及其衍生物在制备治疗冠状病毒感染方面的药物中的应用

Publications (2)

Publication Number Publication Date
TW202224673A TW202224673A (zh) 2022-07-01
TWI800875B true TWI800875B (zh) 2023-05-01

Family

ID=72486782

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110126933A TWI800875B (zh) 2020-07-24 2021-07-22 苯芴醇及其衍生物在治療冠狀病毒感染方面的應用

Country Status (6)

Country Link
US (1) US20230263748A1 (zh)
EP (1) EP4209209A1 (zh)
JP (1) JP2023534723A (zh)
CN (1) CN111686096B (zh)
TW (1) TWI800875B (zh)
WO (1) WO2022017431A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111803491A (zh) * 2020-07-24 2020-10-23 中国人民解放军军事科学院军事医学研究院 青蒿素类化合物在治疗冠状病毒感染方面的应用
CN111686096B (zh) * 2020-07-24 2021-05-14 中国人民解放军军事科学院军事医学研究院 苯芴醇及其衍生物在制备治疗冠状病毒感染方面的药物中的应用
CN114306338B (zh) * 2020-09-29 2025-04-25 苏州系统医学研究所 双四氢异喹啉类化合物在制备用于预防和/或治疗冠状病毒感染的药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1042535A (zh) * 1988-11-10 1990-05-30 军事医学科学院微生物流行病研究所 抗疟新药苯芴醇的合成新工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021211923A1 (en) * 2020-04-16 2021-10-21 Pulmoquine Therapeutics, Inc. Compositions and methods for treating disease
CN111803491A (zh) * 2020-07-24 2020-10-23 中国人民解放军军事科学院军事医学研究院 青蒿素类化合物在治疗冠状病毒感染方面的应用
CN111686096B (zh) * 2020-07-24 2021-05-14 中国人民解放军军事科学院军事医学研究院 苯芴醇及其衍生物在制备治疗冠状病毒感染方面的药物中的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1042535A (zh) * 1988-11-10 1990-05-30 军事医学科学院微生物流行病研究所 抗疟新药苯芴醇的合成新工艺

Also Published As

Publication number Publication date
CN111686096A (zh) 2020-09-22
CN111686096B (zh) 2021-05-14
US20230263748A1 (en) 2023-08-24
EP4209209A1 (en) 2023-07-12
JP2023534723A (ja) 2023-08-10
TW202224673A (zh) 2022-07-01
WO2022017431A1 (zh) 2022-01-27

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