TWI849623B - Magnetic separation device - Google Patents

Abstract

A magnetic separation device is provided. The magnetic separation device includes a sleeve and two fixing portion. The sleeve includes a sleeve body and a hollow portion, and the hollow portion is passed through the inside of the sleeve body. Each fixing portion is respectively arranged on the opposite first end and second end of the sleeve body, and each fixing portion includes a protruding body and a groove, each protruding body protrudes from the outer surface of the sleeve body, and the groove is provided on the outer surface of the protruding body.

Description

Magnetic separation device

The present invention relates to a magnetic separation device.

When conducting experiments to separate magnetic substances, it is necessary to be able to quickly and in large quantities separate magnetic substances from biological samples without affecting the safety of the biological samples, such as affecting the survival of biological samples. In addition, different biological samples often need to be separated and cannot interfere with each other and contaminate each other, so efficiency, convenience, automation, biosafety and biocompatibility must be considered. Often, those with good separation efficiency are inconvenient to use or fail to pass the biosafety and biocompatibility tests; those that are easy to use have poor separation efficiency, etc. It is impossible to cover all aspects. Therefore, how to provide a magnetic separation device to improve the above problems will be a problem that the industry needs to solve.

The disclosed embodiment provides a magnetic separation device that can be replaced according to different biological samples and can select surface materials or surface treatments according to different biological samples.

The magnetic separation device of the disclosed embodiment includes a sleeve and two fixing parts. The sleeve includes a sleeve body and a hollow part, and the hollow part is arranged inside the sleeve body. Each fixing part is respectively arranged at a first end and a second end opposite to each other of the sleeve body, and each fixing part includes a protruding body and a groove, each protruding body protrudes from an outer surface of the sleeve body, and the groove is arranged on an outer surface of the protruding body.

In order to make this disclosure more clear and easy to understand, the following is a specific example and a detailed description with the attached drawings.

100,200,300,400,500: Magnetic separation device

110,510: casing

112,512: Casing body

112A: First end

112B: Second end

120A, 120B, 220A, 220B, 320A, 320B, 420A: Fixed part

122,222: protruding body

124: Upper wall

126,326,426: Lower wall

514: Spiral grooves

A: Axial direction

G1,G2: Groove

H: Hollow part

K1: First hole

K2: Second hole

L: Distance

M1: Separation tube

N:Through slot

P: Magnetic parts

T1, T2: extension groove

T11, T21: First end

T12, T22: Second end

Figure 1 is a schematic diagram of an embodiment of the magnetic separation device disclosed herein.

Figure 2 is a schematic top view of the magnetic separation device disclosed herein.

Figure 3 is a schematic diagram of another embodiment of the magnetic separation device disclosed herein.

Figure 4 is a schematic diagram of the fixed part of Figure 3 from one angle.

Figure 5 is a schematic diagram of the separation tube installation of the magnetic separation device in Figure 3.

Figure 6 is a schematic diagram of another embodiment of the magnetic separation device disclosed herein.

Figure 7A is a schematic diagram of a viewing angle of the fixed part of Figure 6.

Figure 7B is a schematic diagram of the fixing part of Figure 6 from another angle.

Figure 8A is a schematic diagram showing a perspective of the fixed portion of the magnetic separation device disclosed herein.

Figure 8B is a schematic diagram showing another angle of the fixing portion of the magnetic separation device disclosed herein.

Figure 9 is a schematic diagram of another embodiment of the magnetic separation device disclosed herein.

The following is a detailed description of the embodiments and accompanying drawings, but the embodiments provided are not intended to limit the scope of the present disclosure. In addition, the drawings are for illustrative purposes only and are not drawn in original size. For ease of understanding, the same components will be indicated by the same symbols in the following description.

The terms "including", "comprising", "having" and the like mentioned in this disclosure are all open terms, which means "including but not limited to".

In the description of each embodiment, when the terms "first", "second", etc. are used to describe an element, they are only used to distinguish these elements from each other and do not limit the order or importance of these elements.

In the description of each embodiment, the so-called "coupling" or "connection" may refer to two or more elements making direct physical or electrical contact with each other, or making indirect physical or electrical contact with each other, and "coupling" or "connection" may also refer to two or more elements operating or acting on each other.

FIG. 1 is a schematic diagram of an embodiment of the magnetic separation device disclosed in the present invention. FIG. 2 is a schematic diagram of a top view of the magnetic separation device disclosed in the present invention. Referring to FIG. 1 and FIG. 2, the magnetic separation device 100 disclosed in the present invention is, for example, integrally formed, and includes a sleeve 110 and two fixing portions 120A and 120B. The sleeve 110 includes a sleeve body 112 and a hollow portion H, the hollow portion H is penetrated through the interior of the sleeve body 112, and the hollow portion H is a straight through hole, that is, the sleeve body 112 has a hollow portion H with a straight through hole, the sleeve body 112 is, for example, a cylinder, and the hollow portion H is, for example, a circular through hole or a blind hole. The outer surface of the sleeve body 112 can be a smooth structure. The material of the sleeve body 112 is a material that allows magnetic lines of force to pass through (such as silicone, plastic). The hollow portion H disclosed herein can accommodate a magnetic component P of corresponding size. The size of the hollow portion H can be adjusted according to the size of the magnetic component P, so that the inside of the sleeve body 112 can be tightly attached to the magnetic component P. The magnetic component P can be replaced according to the different biological samples that need to be separated and processed.

The fixing parts 120A and 120B disclosed herein are respectively disposed at a first end 112A and a second end 112B opposite to each other of the sleeve body 112. The fixing parts 120A and 120B are of the same type, and the distance L between the fixing parts 120A and 120B is the length of the sleeve body 112, which can be adjusted according to the actual situation. The fixing parts 120A and 120B each include a protruding body 122 and a groove G1. The protruding body 122 protrudes from the outer surface of the first end 112A and the second end 112B of the sleeve body 112. The protruding body 122 is, for example, a cylinder, that is, the radius of the protruding body 122 is larger than the radius of the sleeve body 112. In other embodiments, the protruding body 122 can also be other components or protrusions. The protruding body 122 includes an upper wall surface 124 and a lower wall surface 126 opposite to each other. The two lower walls 126 are respectively adjacent to the first end 112A and the second end 112B of the sleeve body 112.

The groove G1 disclosed in the present invention is disposed on the outer surface of the protruding body 122. Specifically, the groove G1 is a notch in the protruding body 122, and the groove G1 is from the upper wall surface 124 of the protruding body 122 to the lower wall surface 126 of the protruding body 122, wherein the groove G1 has a first hole portion K1 on the upper wall surface 124 of the protruding body 122, and the first hole portion K1 is a circular hole as shown in FIG. 2; the groove G1 has a second hole portion K2 on the lower wall surface 126 of the protruding body 122, and the shape of the second hole portion K2 is similar to that of the first hole portion K1. The groove G1 is formed between the first hole portion K1 and the second hole portion K2, and the size and shape of the groove G1 can be adjusted according to the actual state.

In this embodiment, the extension direction of the groove G1 formed from the first hole portion K1 to the second hole portion K2 is parallel to the axial direction A of the sleeve body 112. In other words, the line from the position of the first hole portion K1 on the upper wall 124 of the protruding body 122 to the position of the second hole portion K2 on the lower wall 126 of the protruding body 122 is parallel to the axial direction A of the sleeve body 112.

However, the present disclosure is not limited thereto, please refer to Figure 3 and Figure 4, Figure 3 is a schematic diagram of another embodiment of the magnetic separation device of the present disclosure. Figure 4 is a schematic diagram of a viewing angle of the fixing part of Figure 3. The magnetic separation device 200 in FIG. 3 is similar to the magnetic separation device 100 in FIG. 1, and the difference lies in the groove G2 of the fixing parts 220A and 220B. The groove G2 is provided on the outer surface of the protruding body 222. The first hole part K1 to the second hole part K2 form the extension direction of the groove G2. The extension direction of the groove G2 is not parallel to the axial direction A of the sleeve body 112. In other words, the line from the position of the first hole part K1 on the upper wall 124 of the protruding body 222 to the position of the second hole part K2 on the lower wall 126 of the protruding body 222 is not parallel to the axial direction A of the sleeve body 112, but has a tilt angle, which can be adjusted according to the actual situation.

Under this configuration, as shown in FIG. 5 , the present disclosure uses a certified biocompatible tube as the separation tube M1. The outer surface material of the separation tube M1 can be treated with corresponding surface treatment according to the different biological samples to be separated. The separation tube M1 can be inserted from the groove G2 of the fixing portion 220A, along the outer surface of the sleeve body 112, and finally exit from the groove G2 of the fixing portion 220B. That is, the fixing portions 220A and 220B are structures used to fix the head end and the tail end of the separation tube. Furthermore, since the sleeve body 112 is a smooth structure, the separation tube M1 can directly contact the sleeve 110 to increase the contact area. Together with the magnetic member P in the sleeve 110 (as shown in FIG. 2 ), the magnetic field lines have a more pronounced effect. When a biological sample containing magnetic substances that need to be separated enters the magnetic separation device 200, the magnetic substances can be separated stably and efficiently, and the biological sample can be ensured not to be poisoned or damaged by foreign objects. In addition, the present disclosure uses the extension direction of the groove G2 as an inclination, and extends outward from the first end 112A and the second end 112B of the sleeve body 112. In this way, the separation tube M1 can go out along the extension direction of the groove G2 along the direction of winding around the sleeve body 112, reducing the probability of deformation and twisting of the separation tube M1 at both ends of the fixing parts 220A and 220B, thereby increasing the probability of biological sample circulation.

Fig. 6 is a schematic diagram of another embodiment of the magnetic separation device disclosed herein. Fig. 7A is a schematic diagram of a fixed portion of Fig. 6 from one viewing angle. Fig. 7B is a schematic diagram of a fixed portion of Fig. 6 from another viewing angle. The magnetic separation device 300 of FIG. 6 is similar to the magnetic separation device 200 of FIG. 3 , except that the fixing portions 320A and 320B include an extension groove T1, which is recessed in the wall surface of the protruding body 222 (such as the lower wall surface 326 of FIG. 6 ), that is, the lower wall surface 326 is grooved to form an extension groove T1, and the extension groove T1 includes a first end T11 and a second end T12 opposite to each other, and the first end T11 of the extension groove T1 is connected to the groove G2, and the width of the first end T11 of the extension groove T1 gradually decreases to the width of the second end T12, forming a gradient groove. In this way, the extension groove T1 can be used to increase the space for the separation tube (not shown) to extend, thereby preventing the separation tube from being squeezed and deformed at both ends of the fixing parts 320A and 320B.

It should be noted that the depth of the first end T11 of the extended groove T1 (as shown in FIG. 7A) (the depth of the groove from the lower wall surface 326) can be adjusted according to the actual situation. For example, the magnetic separation device 400 in FIG. 8A and FIG. 8B is similar to the magnetic separation device 300 in FIG. 6. The groove is also formed on the lower wall surface 426 to form an extended groove T2. The width of the extended groove T2 gradually decreases from the first end T21 to the second end T22, forming a gradient groove. The difference is that the depth of the first end T21 of the extended groove T2 of the fixed portion 420A is greater than the depth of the first end T11 of the extended groove T1 in FIG. 6.

FIG. 9 is a schematic diagram of another embodiment of the magnetic separation device disclosed herein. Referring to FIG. 9, the magnetic separation device 500 disclosed herein is similar to the magnetic separation device 100 of FIG. 1 above, and the difference lies in the sleeve 510. The outer surface of the sleeve body 512 of the sleeve 510 is a non-smooth structure, such as a rough surface, and the outer surface of the sleeve body 512 can also be a spiral groove 514. In addition, the sleeve 510 includes a through groove N, which is located on the outer surface of the sleeve body 512 and is connected to the hollow part H. In other words, the sleeve 510 disclosed herein is C-shaped, so that the sleeve 510 can be tightly attached to the magnetic member in the hollow part H.

In summary, the magnetic separation device disclosed herein can be used in magnetic material separation applications. It can be replaced accordingly with different biological samples to be processed, and can take into account both the efficiency of separating magnetic materials and reducing the impact on biological samples.

Although the present disclosure has been disclosed as above by way of embodiments, it is not intended to limit the present disclosure. Anyone with ordinary knowledge in the relevant technical field may make some changes and modifications within the spirit and scope of the present disclosure. Therefore, the protection scope of the present disclosure shall be subject to the scope defined in the attached patent application.

100: Magnetic separation device 110: Sleeve 112: Sleeve body 112A: First end 112B: Second end 120A, 120B: Fixing part 122: Protruding body 124: Upper wall surface 126: Lower wall surface A: Axial direction G1: Groove H: Hollow part K1: First hole part K2: Second hole part L: Distance

Claims (8)

A magnetic separation device includes: a sleeve, including a sleeve body, a hollow part, and a through-groove, wherein the hollow part is penetrated inside the sleeve body, the through-groove is located on an outer surface of the sleeve body, and the through-groove is connected to the hollow part; and two fixing parts, which are respectively arranged at a first end and a second end of the sleeve body opposite to each other, and each of the fixing parts includes a protruding body and a groove, each of the protruding bodies protrudes from an outer surface of the sleeve body, and the groove is arranged on an outer surface of the protruding body. A magnetic separation device as described in claim 1, wherein the outer surface of the sleeve body is a smooth structure. A magnetic separation device as described in claim 1, wherein the outer surface of the sleeve body is a non-smooth structure. A magnetic separation device as described in claim 1, wherein the outer surface of the sleeve body is a spiral groove. A magnetic separation device as described in claim 1, wherein the extension direction of the groove is parallel to the axial direction of the sleeve body. A magnetic separation device as described in claim 1, wherein the extension direction of the groove is not parallel to the axial direction of the sleeve body. A magnetic separation device as described in claim 1, wherein each of the fixing portions comprises an extension groove, and the extension groove is recessed in an inner wall of the protruding body. A magnetic separation device as described in claim 7, wherein one end of the extension groove is connected to the groove.

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