TWI728449B - Composite material structure applied to biological test piece and manufacturing method thereof - Google Patents

Abstract

The present invention provides a composite material structure applied to biological test piece and manufacturing method thereof. The composite material structure includes a substrate, a precious-metal-free conductive element, and a precious-metal-free adhesion layer. The precious-metal-free conductive element is disposed on the substrate. The precious-metal-free adhesion layer is disposed on the precious-metal-free conductive element. Therefore, the composite material structure applied to biological test piece and manufacturing method thereof of the present invention can improve production efficiency and reduce cost.

Description

Composite material structure applied to biological test piece and manufacturing method thereof

The invention relates to a composite material structure and a manufacturing method thereof, in particular to a composite material structure applied to a biological test piece and a manufacturing method thereof.

Modern people are becoming younger and younger due to changes in dietary habits, high pressure in life, and abnormal living habits. Therefore, the detection of physiological conditions is of great importance. In addition to helping the general public to confirm their own health conditions, for patients, the detection of physiological conditions can enhance their therapeutic effects and grasp the course of their disease.

In view of the above problems, various test strips have appeared on the market. However, in the existing material structure of the test piece, not only precious metals are used, but also, after a general manufacturing process, it needs to be baked at a high temperature (>150°C) through a heat treatment process.

Therefore, how to provide a composite material structure for biological test strips that can eliminate the use of precious metals and shorten the manufacturing process to increase productivity and reduce costs has become one of the important issues.

The technical problem to be solved by the present invention is to provide a composite material structure applied to a biological test piece and a manufacturing method thereof in view of the deficiencies of the prior art.

In order to solve the above technical problems, one of the technical solutions adopted by the present invention Yes, a composite material structure applied to a biological test piece is provided, which includes a substrate, a conductive unit that does not contain precious metals, and an adhesion layer that does not contain precious metals. Conductive units that do not contain precious metals are arranged on the substrate. An adhesion layer containing no precious metal is provided on the conductive unit.

In order to solve the above technical problems, another technical solution adopted by the present invention is to provide a method for manufacturing a composite material structure applied to biological test strips, which includes: providing a substrate; forming a conductive unit that does not contain precious metals on On the substrate; and forming a noble metal-free adhesion layer on the conductive unit.

One of the beneficial effects of the present invention is that the composite material structure applied to biological test strips provided by the present invention can be provided by "a conductive unit containing no precious metal on the substrate" and "a noble metal-free adhesion layer" Set on the conductive unit" technical solution to improve production efficiency and reduce costs.

Another beneficial effect of the present invention is that the method for manufacturing a composite material structure applied to biological test strips provided by the present invention can "provide a substrate" and "form a conductive unit free of precious metals on the substrate. "And the technical solution of "forming a noble metal-free adhesion layer on the conductive unit" to improve production efficiency and reduce costs.

In order to further understand the features and technical content of the present invention, please refer to the following detailed description and drawings about the present invention. However, the drawings provided are only for reference and description, and are not used to limit the present invention.

Z: Composite material structure

1: substrate

2: conductive unit

20: The first conductive layer

21: second conductive layer

3: Adhesion layer

FIG. 1 is a flowchart of a method for manufacturing a composite material structure applied to a biological test piece according to a first embodiment of the present invention.

2 is a schematic structural diagram of a composite material structure applied to a biological test piece according to the first embodiment of the present invention.

3 is a flowchart of a method for manufacturing a composite material structure applied to a biological test piece according to a second embodiment of the present invention.

4 is a schematic structural diagram of a composite material structure applied to a biological test piece according to a second embodiment of the present invention.

Fig. 5 is a graph showing the results of the blood glucose test of the composite material applied to the biological test strip of the present invention.

The following are specific examples to illustrate the implementation of the "composite material structure applied to biological test strips and its production method" disclosed in the present invention. Those skilled in the art can understand the present invention from the content disclosed in this specification. Advantages and effects. The present invention can be implemented or applied through other different specific embodiments, and various details in this specification can also be based on different viewpoints and applications, and various modifications and changes can be made without departing from the concept of the present invention. In addition, the drawings of the present invention are merely schematic illustrations, and are not drawn according to actual dimensions, and are stated in advance. The following embodiments will further describe the related technical content of the present invention in detail, but the disclosed content is not intended to limit the protection scope of the present invention.

It should be understood that although terms such as “first”, “second”, and “third” may be used herein to describe various elements, these elements should not be limited by these terms. These terms are mainly used to distinguish one element from another. In addition, the term "or" used in this document may include any one or a combination of more of the associated listed items depending on the actual situation.

[First Embodiment]

1 and 2, the first embodiment of the present invention provides a method for manufacturing a composite material structure Z applied to a biological test strip, which at least includes the following steps: First, a substrate 1 is provided (step S100). For example, as shown in FIGS. 1 and 2, the substrate 1 can be polyimide (PI), high-density polyethylene (HDPE), polyethylene terephthalate (PET), polycarbonate (PC) or polystyrene (PS). However, the present invention is not limited to the above-mentioned examples.

Next, a conductive unit 2 containing no precious metal is formed on the substrate 1 (step S102). For example, as shown in FIG. 1 and FIG. 2, the conductive unit 2 is formed on the substrate 1. The conductive unit 2 includes a first conductive layer 20, and the thickness of the first conductive layer 20 may be between 1 nm and 5000 nm. The first conductive layer 20 can be a metal, an alloy, a conductive polymer or a conductive compound; and the first conductive layer 20 of the present invention does not contain precious metals, and the precious metals that do not contain can be gold (Au), silver (Ag), platinum ( Pt) or a combination thereof. Among them, the first conductive layer 20 of the present invention may be a highly dense structure with no or less pores.

Further, the metal may be aluminum (Al), titanium (Ti), molybdenum (Mo), copper (Cu), nickel (Ni), tin (Sn), or zinc (Zn). The conductive polymer can be Poly-3,4-Ethylenedioxythiophene (PEDOT), Polypyrrole (PPy) or Polyaniline (PAn). The conductive compound may be a compound of at least one of tungsten, nitrogen, and carbon, or a combination thereof. The alloy may be at least two of aluminum (Al), titanium (Ti), molybdenum (Mo), copper (Cu), nickel (Ni), tin (Sn), and zinc (Zn). However, the present invention is not limited to the above-mentioned examples.

Next, an adhesion layer 3 containing no precious metal is formed on the conductive unit 2 (step S104). For example, as shown in FIGS. 1 and 2, after the conductive unit 2 is formed, then an adhesion layer 3 is formed on the conductive unit 2, that is, the adhesion layer 3 is formed on the first conductive layer 20; and, the present invention The adhesion layer 3 does not contain precious metals, and the precious metals not included can be gold (Au), silver (Ag), platinum (Pt) or a combination thereof. The thickness of the adhesion layer 3 may be between 1 nm and 5000 nm. The adhesion layer 3 can be carbide, silicon (Si), silicide or carbon (C), and the carbon is graphite or graphene.

Furthermore, the conductive unit 2 (that is, the first conductive layer 20) and the adhesion layer 3 can be It is formed in an environment with a temperature of less than 150°C and does not require heat treatment. In addition, the conductive unit 2 and the adhesion layer 3 are layers of different materials. However, the present invention is not limited to the above-mentioned examples.

Based on the above content, the first embodiment of the present invention also provides a composite material structure Z applied to a biological test strip, which may include a substrate 1, a conductive unit 2 free of precious metals, and an adhesion layer 3 free of precious metals. The conductive unit 2 containing no precious metal is provided on the substrate 1. An adhesion layer 3 that does not contain noble metals is provided on the conductive unit 2.

Accordingly, the composite material structure Z applied to the biological test piece and the manufacturing method provided by the present invention can pass the above technical solution without using precious metals; and the prepared film has good compactness (density> 90%). ).

However, the above-mentioned example is only one of the feasible embodiments and is not intended to limit the present invention.

[Second Embodiment]

3 and 4, the second embodiment of the present invention provides a method for manufacturing a composite material structure Z applied to a biological test strip, which at least includes the following steps: first, a substrate 1 is provided (step S200); , Forming at least one first conductive layer 20 containing no precious metal on the substrate 1 (step S2020); next, forming at least one second conductive layer 21 containing no precious metal on the at least one first conductive layer 20 (step S2021) Next, an adhesion layer 3 containing no precious metal is formed on at least one second conductive layer 21 (step S204).

For example, comparing FIGS. 1 and 2 with FIGS. 3 and 4, the difference between the second embodiment of the present invention and the first embodiment is that the conductive unit 2 of the present invention may include at least one first conductive layer 20 And at least one second conductive layer 21. Therefore, the first conductive layer 20 is formed on the substrate 1 first. Next, a second conductive layer 21 is formed on the first conductive layer 20. Next, an adhesion layer 3 containing no noble metal is formed on the second conductive layer 21, and the second conductive layer 21 is located between the first conductive layer 20 and the adhesion layer 3. Among them, in this embodiment, two conductive layers are taken as an example, namely, a first conductive layer 20 and a second conductive layer 20. The conductive layer 21, but not limited thereto, the composite material structure Z of the present invention may also include two or more layers of the first conductive layer 20, the second conductive layer 21, or both.

Furthermore, the thickness of the first conductive layer 20 and the second conductive layer 21 may be between 1 nm and 5000 nm, and the first conductive layer 20 and the second conductive layer 21 may be metals, alloys, conductive polymers or conductive compounds; and The first conductive layer 20 and the second conductive layer 21 of the present invention do not contain precious metals, and the precious metals not included can be gold (Au), silver (Ag), platinum (Pt) or a combination thereof. The metal may be aluminum (Al), titanium (Ti), molybdenum (Mo), copper (Cu), nickel (Ni), tin (Sn), or zinc (Zn). The conductive polymer can be Poly-3,4-Ethylenedioxythiophene (PEDOT), Polypyrrole (PPy) or Polyaniline (PAn). The conductive compound may be a compound of at least one of tungsten, nitrogen, and carbon, or a combination thereof. The alloy may be at least two of aluminum (Al), titanium (Ti), molybdenum (Mo), copper (Cu), nickel (Ni), tin (Sn), and zinc (Zn). However, the present invention is not limited to the above-mentioned examples. It is worth mentioning that the materials of the first conductive layer 20 and the second conductive layer 21 can be partially the same or completely different, but not limited to this, and can also be selected to be completely the same.

In addition, the first conductive layer 20 and the second conductive layer 21 of the present invention can be a highly dense structure with no or less pores.

However, the above-mentioned example is only one of the feasible embodiments and is not intended to limit the present invention.

In addition, as shown in FIG. 5, it is the result of the blood glucose test performed by the composite material structure Z of the biological test strip of the above embodiments of the present invention. As shown in Figure 5, the vertical axis represents the normalized intensity (unit is arbitrary unit, au), which is that the blood glucose monitor (Blood Glucose Monitor, BGM) data is standardized (measured value/full range), which does not affect the final Linear regression results; the horizontal axis is the concentration of glucose (in mg/dl). Through the detection of the composite material structure Z of the biological test piece of the present invention, multiple parameter values (as shown in the following table) are measured. Among them, the curve in Fig. 5 uses the standardized intensity value (Y) to make a standard curve of the corresponding glucose concentration (X), that is, Y=0.002X+0.0382, R ² =09991.

[Beneficial effects of the embodiment]

One of the beneficial effects of the present invention is that the composite material structure Z applied to biological test strips provided by the present invention can be provided by "precious metal-free conductive unit 2 is arranged on substrate 1" and "precious metal-free adhesion The layer 3 is arranged on the conductive unit 2" to improve production efficiency and reduce costs.

Another beneficial effect of the present invention is that the method for manufacturing the composite material structure Z applied to biological test strips provided by the present invention can be achieved by "providing a substrate 1" and "forming a conductive unit 2 free of precious metals." The technical solutions of "on the substrate 1" and "form a noble metal-free adhesion layer 3 on the conductive unit 2" can improve production efficiency and reduce costs.

Furthermore, the composite material structure Z applied to biological test strips and the manufacturing method thereof provided by the present invention not only do not use precious metals, but also reduce the cost through the above technical solutions; preferably, through the vacuum process technology, To shorten the manufacturing process and improve production efficiency, and the prepared film has good compactness (density>90%).

The content disclosed above is only a preferred and feasible embodiment of the present invention, not for this reason. The scope of the patent application of the present invention is limited, so all equivalent technical changes made by using the description of the present invention and the content of the drawings are included in the scope of the present invention.

Composite material structure　Z Substrate　　　　　　1 Conductive unit 　　　　2 　　　First conductive layer　　　20 Adhesion layer 　　　　　3

Claims (10)

A composite material structure applied to a biological test strip, comprising: a substrate; a conductive unit free of precious metals, which is arranged on the substrate; and an adhesion layer free of precious metals, which is arranged on the conductive unit; Wherein, the conductive unit includes at least one first conductive layer disposed on the substrate and at least one second conductive layer disposed on at least one of the first conductive layers, and at least one second conductive layer is interposed between at least one of the first conductive layers. Between a conductive layer and the adhesion layer; wherein at least one of the first conductive layer and at least one of the second conductive layer is a metal, an alloy, a conductive polymer or a conductive compound, at least one of the first conductive layer and at least one of the The precious metal not included in the second conductive layer is gold, silver or platinum. As described in item 1 of the scope of patent application, the composite material structure applied to biological test strips, wherein the substrate is polyimide, high-density polyethylene, polyethylene terephthalate, polycarbonate or poly Styrene; wherein, the thickness of the first conductive layer is between 1 and 5000 nm. As described in item 1 of the scope of patent application, the composite material structure applied to biological test strips, wherein the metal is aluminum, titanium, molybdenum, copper, nickel, tin or zinc; wherein the conductive polymer is polydioxyl Thiophene, polypyrrole or polyaniline; wherein the conductive compound is a compound of at least one of tungsten, nitrogen, and carbon, or a combination thereof. As described in the first item of the scope of patent application, the composite material structure applied to biological test strips, wherein the adhesion layer is carbon, carbide, silicon or silicide, and the carbon is graphite or graphene; wherein, the adhesion layer is The noble metal that is not included is gold, silver or platinum; wherein, the thickness of the adhesion layer is between 1 and 5000 nm; wherein, the conductive unit and the adhesion layer are layers of different materials. As described in the first item of the scope of patent application, the composite material structure applied to biological test strips, wherein the thickness of at least one first conductive layer and at least one second conductive layer is between 1 nm and 5000 nm. A method for manufacturing a composite material structure applied to a biological test piece, comprising the following steps: providing a substrate; forming a conductive unit without precious metals on the substrate; and forming an adhesion layer without precious metals on the conductive unit On; wherein, the conductive unit includes at least one first conductive layer and at least one second conductive layer, and the step of forming the conductive unit free of precious metals on the substrate further includes: forming at least one free of precious metals The first conductive layer is on the substrate; and at least one second conductive layer containing no precious metal is formed on at least one of the first conductive layers; wherein at least one of the second conductive layers is interposed between at least one of the first conductive layers Layer and the adhesion layer; wherein at least one first conductive layer and at least one second conductive layer are metal, alloy, conductive polymer or conductive compound, at least one first conductive layer and at least one second conductive layer The precious metals that are not included are gold, silver or platinum. As described in item 6 of the scope of patent application, the method for manufacturing a composite material structure applied to a biological test piece, wherein the substrate is polyimide, high-density polyethylene, polyethylene terephthalate, polycarbonate Ester or polystyrene; wherein the adhesion layer is carbon, carbide, silicon or silicide, and the carbon is graphite or graphene; wherein the thickness of the adhesion layer is between 1 and 5000 nm; wherein, the first conductive layer and The adhesion layer is a layer of different materials. As described in item 7 of the scope of patent application, the method for manufacturing a composite material structure applied to biological test strips, wherein the metal is aluminum, titanium, molybdenum, copper, nickel, tin or zinc; wherein the conductive polymer is poly Oxyethylthiophene, polypyrrole or polyaniline; wherein the conductive compound is a compound of at least one of tungsten, nitrogen, and carbon, or a combination thereof; wherein the thickness of the first conductive layer is between 1 nm and 5000 nm. As described in item 6 of the scope of patent application, the method for manufacturing a composite material structure applied to a biological test piece, wherein the thickness of at least one first conductive layer and at least one second conductive layer is between 1 nm and 5000 nm. As described in item 6 of the scope of patent application, the method for manufacturing a composite material structure applied to a biological test piece, wherein the conductive unit and the adhesion layer are a high-density structure with no or few pores, and the high-density structure is The density is greater than 90%; wherein, the conductive unit and the adhesion layer do not need to be processed by heat treatment.

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