TWI717992B - Optical pulse image measuring device and method for analyzing change of pulse waveform - Google Patents

Abstract

The present disclosure provides an optical pulse image measuring device including a base, a cover, an imaging module, a light source module, a structured light projection module, a circuit module, a computing module and a display module. The cover is disposed on the base. The imaging module is disposed within the cover and for capturing an image in an imaging area. The light source module is disposed on one side of the imaging module. The structured light projection module is disposed within the cover. The circuit module is electrically connected to the imaging module and the light source module. The computing module is signally connected to the circuit module. The display module is signally connected to the computing module. Therefore, the optical pulse image measuring device of the present disclosure can capture pulse images on wrists of a subject by the imaging module and visualize the pulse condition information so as to obtain pulse measurement results with high accuracy.

Description

Optical pulse wave image measuring instrument and pulse wave variable measuring method

The present invention relates to a pulse condition measuring instrument, in particular to an optical pulse wave image measuring instrument that uses an optical imaging system to measure and analyze the pulse wave image.

In the traditional pulse detection, the Chinese physician presses the radial artery of the patient’s wrist by touching, touching, pressing and other actions to feel the pulse conditions of the patient’s hands and wrists at the floating, middle and sinking depths of the three parts of the wrist, Guan, and Ulnar. Different pressures are used to sense different pulse changes. However, the accuracy of pulse diagnosis will vary depending on the palpation position, palpation habits, and pressing strength of different TCM physicians, and it is impossible to describe the pulse condition objectively. As a result, the result of the pulse condition change will be greater. Variability makes it easier to send wrong diagnosis results to patients.

In order to solve the above-mentioned problems, related technicians have proposed a tactile-combined pulse assisting device, which uses a traditional Chinese medicine practitioner to wear a pulse assisting device including a sensing unit on the finger to detect the pulse that the traditional Chinese doctor applies to the patient’s wrist in real time. The amount of pressure, in order to adjust the pressure in the process of pulse, The pulse information obtained can be digitized to provide the patient with an objective pulse diagnosis result. However, the aforementioned tactile sensation combined with the pulse assisting device still requires the Chinese physician to determine the palpation position and apply pressure to the patient’s wrist during the pulse detection process, and the palpation position and pressing force cannot be standardized. There are still differences in the pulse diagnosis results sent by the patients.

In order to solve the above-mentioned problems, related technicians have even proposed a pulse diagnosis detector that uses a compression device such as a balloon to pressurize the radial artery of the patient, and captures the pulse pressure signal reflected after the compression for analysis, so as to obtain a standardized pulse diagnosis. result. However, although the aforementioned pulse diagnosis detector can avoid the error of results caused by the palpation habits of different Chinese physicians, it still needs to apply external force to the patient's wrist and perform contact diagnosis to obtain the relative pulse pressure signal for follow-up The determination of the pulse diagnosis result is not only complicated in the operation method, but also may affect the accuracy of the pulse diagnosis result due to the contact pulse method.

Therefore, there is an urgent need for a pulse measuring instrument that is convenient to use and achieves objective pulse results.

One aspect of the present invention is to provide an optical pulse wave image measuring instrument, comprising a base, a housing, an imaging module, a light source module, a structured light projection device, a circuit module, and a computing module And a display module. The outer cover is arranged on the base. The light source module is arranged on one side of the imaging module. The structured light projection device is arranged in the outer cover. The imaging module is arranged in the outer cover, and the imaging module is used to capture an image of an area to be measured, where the area to be measured includes a wrist area of a subject. The light source module is set in the imaging module One side of the group. The circuit module is electrically connected to the imaging module and the light source module. The calculation module signal is connected to the circuit module. The display module signal is connected to the calculation module.

Another aspect of the present invention is to provide a pulse waveform variable measurement method, which includes the following steps: performing a positioning adjustment step, which uses an image positioning auxiliary method to align an imaging module to a subject A wrist area, and adjust the imaging module and a structured light projection device to a measurement position, where the wrist area includes three parts: inch, close, and ruler; perform a shooting step, which uses the imaging module to capture the wrist area An image information; an operation step is performed, which uses an operation module to analyze the image information to obtain a pulse waveform transformation operation result.

100: Optical pulse wave image measuring instrument

111: Wrist Pillow

120: outer cover

200: imaging module

202: Imaging Polarizer

204: imaging lens

206: Image Sensor

208: synchronization circuit

300: light source module

302: Light source polarizer

304: light source

308: synchronization circuit

400: circuit module

402: power supply circuit

404: control circuit

406: drive circuit

408: Data Transmission Circuit

500: Computing module

600: display module

700: Structured light projection device

702: light source polarizer

704: structured light source

708: synchronization circuit

720: Digital micromirror device

730: mirror

800: mobile module

900: Pulse measurement method

910,920,930,940: steps

11: wrist area

A: Area to be tested

P: projection fringe

R: beam

In order to make the above and other objectives, features, advantages and embodiments of the present invention more comprehensible, the description of the accompanying drawings is as follows:

Figure 1 is a schematic diagram showing the structure of an optical pulse wave image measuring instrument according to an embodiment of the present invention;

Figure 2 is a schematic diagram of an optical pulse wave image measuring instrument according to an embodiment of the present invention;

Figure 3 is a partial cross-sectional view of the optical pulse wave imaging measuring instrument of the embodiment in Figure 2;

Fig. 4 is an enlarged schematic diagram of the imaging module, structured light projection device and mobile module of the optical pulse wave image measuring instrument in the embodiment of Fig. 3;

FIG. 5 is an enlarged schematic diagram of the structured light projection device and the mobile module of the optical pulse wave image measuring instrument of the embodiment in FIG. 4;

Fig. 6 is an enlarged schematic diagram of the structured light projection device of the optical pulse wave image measuring instrument of the embodiment in Fig. 5;

Fig. 7 is a schematic diagram showing the operating state of the optical pulse wave imaging measuring instrument of the embodiment in Fig. 2; and

Fig. 8 is a flowchart of a pulse condition measurement method according to another embodiment of the present invention.

Hereinafter, a plurality of embodiments of the present invention will be described with reference to the drawings. For the sake of clarity, many practical details will be explained in the following description. However, it should be understood that these practical details should not be used to limit the present invention. That is to say, in some embodiments of the present invention, these practical details are unnecessary. In addition, for the sake of simplification of the drawings, some conventionally used structures and elements will be shown in a simple schematic manner in the drawings; and repeated elements may be represented by the same number.

Please refer to Figure 1, Figure 2, and Figure 3. Figure 1 is a schematic diagram showing the structure of an optical pulse wave image measuring instrument according to an embodiment of the present invention, and Figure 2 is a schematic diagram showing an embodiment of the present invention. A schematic diagram of the optical pulse wave image measuring instrument 100 of the embodiment, and FIG. 3 is a partial cross-sectional view of the optical pulse wave image measuring instrument 100 of the embodiment in FIG. 2. The purpose of the present invention is to provide an optical pulse wave image measuring instrument 100 for detecting the pulse state of a test area A of a subject (not shown), which includes a base 110, a cover 120, and an imaging device. Module 200, a light source module 300, a structured light projection device 700, a circuit module 400, a computing module 500, and A display module 600.

The base 110 may include an auxiliary device for measuring position (not shown in the figure) and an auxiliary wrist fixing jig (not shown in the figure) to assist the area A to be measured to be placed in an appropriate position. Preferably, the base 110 may include a wrist pillow 111 (marked in Figure 3) to increase the efficiency of wrist fixation. The cover 120 is disposed on the base 110. Preferably, the outer cover 120 can be used to block all ambient light sources in the area A to be measured. Specifically, the outer cover 120 may be a barrier for shielding environmental interference to block all interference light from the surrounding environment, and the material of the outer cover 120 may be a material that does not penetrate through the entire waveband, but the invention is not limited to this.

The imaging module 200 is disposed in the outer cover 120, and the imaging module 200 captures an image of the area A to be measured at a direction angle. The imaging module 200 may include an imaging polarizer 202, an imaging lens 204, an image sensor 206, and a synchronization circuit 208. The imaging polarizer 202 may include a linear polarizer, and the imaging lens 204 may include a plurality of lenses. As for the number of lenses and their setting methods are not the main features of the present invention, they will not be repeated here. The image sensor 206 can be a charge-coupled device (CCD) or a complementary metal-oxide-semiconductor (CMOS), and the invention is not limited thereto.

The light source module 300 is arranged on one side of the imaging module 200, and the light source module 300 may include a light source 304, a light source polarizer 302, and a synchronization circuit 308. The light source polarizer 302 may include a linear polarizer. The imaging polarizer 202 of the imaging module 200 and the light source polarizer 302 of the light source module 300 may be arranged orthogonally, but the present invention is not limited to this. Specifically, the light source module 300 can be arranged on at least one side of the imaging module 200 or coaxially arranged with the imaging module 200. The light source 304 can be an illumination device such as a light-emitting diode (LED) flash, a stroboscopic lamp, or a lamp light source. However, it should be noted here that the number of light source modules 300 can be configured to two or more according to actual needs. The two light source modules 300 are arranged around the periphery of the imaging module 200, so as to provide a comparison of the area to be measured. Good brightness, and the present invention is not limited to the content disclosed in the foregoing description and drawings.

The structured light projection device 700 is arranged in the outer cover 120 to provide structured light in the area to be measured A, and the structured light projection device 700 may include a structured light source 704, a light source polarizer 702, and a synchronization circuit 708, wherein the light source polarizer 702 may include a linear polarizer, and the imaging polarizer 202 of the imaging module 200 and the light source polarizer 702 of the structured light projection device 700 may be arranged orthogonally, but the invention is not limited to this. Specifically, the structured light projection device 700 utilizes non-contact spatial frequency domain imaging (Spatial Frequency Domain Imaging, SFDI) to perform structured light projection, and captures the light reflected after the structured light is projected onto the area to be measured A, and based on The change in the light wave signal presented by the reflected light of the area A to be measured calculates the pulsation position, pulsation depth and other information, and then obtains the pressure waveform changes produced by the hemodynamic changes of the blood vessel in the area A to be measured, and the effect on the diameter and width of the blood vessel A variable of height direction or surrounding tissue. Preferably, the structured light projection device 700 may include a digital optical processing projector (DLP Projector or LCD Projector, and the digital optical processing projector can include a digital micromirror device and a digital micromirror device control module (not shown). Furthermore, the light source spectrum of the structured light projection device 700 may include visible light (wavelength range of approximately 400 nm to 700 nm) to near infrared light (Near Infra Red, NIR, wavelength range of approximately 700 nm to 1000 nm).

The circuit module 400 can be disposed in the base 110 and electrically connected to the imaging module 200, the light source module 300 and the structured light projection device 700, and the circuit module 400 can include a power circuit 402, a control circuit 404, and a driver The circuit 406 and a data transmission circuit 408, wherein the control circuit 404 can be used to control the power of the circuits that may be included in the aforementioned components, and the data transmission circuit 408 can be used to transmit the information of the image captured by the imaging module 200 to the calculation Module 500. In addition, the data transmission circuit 408 may include a wireless communication transmission module (not shown in the figure) or a wired communication transmission module (not shown in the figure), wherein the wireless communication transmission module may be a Bluetooth wireless communication transmission module 1. An infrared wireless communication transmission module or wireless local area network module, but the present invention is not limited to this.

The arithmetic module 500 is signal connected to the circuit module 400, whereby the image information captured by the imaging module 200 is received through the data transmission circuit 408 of the circuit module 400, and the aforementioned image information is analyzed and calculated through the arithmetic module 500. To output a pulse measurement result. Preferably, the arithmetic module 500 may include a computer processor, a mobile device arithmetic unit, or a module that can perform the aforementioned actions, such as a microcontroller (Micro Controller Unit (MCU), Central Processing Unit (CPU), Advanced RISC Machine (ARM), Digital Signal Processor (DSP) or smart mobile device, but the present invention Not limited to this. Preferably, the arithmetic module 500 can analyze the image information of the image of the area A to be measured by the non-contact spatial frequency domain image (SFDI) demodulation algorithm, such as the pressure generated by the hemodynamic changes of blood vessels in the wrist area The waveform change is a response variable to the width and height of the blood vessel or the surrounding tissues, and the pressure wave changes to the pulse structure changes through the measured stress and strain curves to obtain objective and standardized pulse measurement results .

The display module 600 is signally connected to the calculation module 500 to receive and display information such as images and pulse measurement results. The display module 600 may include a display, a wired display device, or a wireless display device. Specifically, the computing module 500 can be built in a mobile device or a personal computer, or can be integrated and built in the housing 120 or the base 110, and the present invention is not limited to any implementation or embodiment .

In addition, as shown in Figure 1, the optical pulse wave image measuring instrument 100 may further include a mobile module 800 connected to the imaging module 200, and the imaging module 200 and the structured light projection device 700 can pass through the mobile module 800 And synchronous displacement. Preferably, the moving module 800 may include a motor, pneumatic cylinder, micro-electromechanical and other moving sources, and may include a moving mechanism (not shown) to drive the imaging module 200 and the structured light projection device 700 in a vertical direction , Horizontal and oblique directions, so that the imaging module 200 and structured light projection The imaging device 700 is adjusted to an appropriate shooting position.

Please refer to Figures 2 and 3, the optical pulse wave image measuring instrument 100 is used to detect the pulse condition at the wrist area 11 (that is, the aforementioned area to be measured A) of a subject, and the optical pulse wave image quantity The structure of the measuring instrument 100 is roughly as shown in Figure 1, which includes a base 110, a cover 120, an imaging module 200, a light source module 300, a structured light projection device 700, a circuit module 400, A computing module 500 and a display module 600.

The base 110 of the optical pulse wave image measuring instrument 100 can be a rectangular base, and the outer cover 120 is a semicircular housing disposed on the base 110 to block all surrounding ambient light. Specifically, the aforementioned light-shielding range is located between the base 110 and the outer cover 120, and the area to be measured is located in the light-shielding range of the outer cover 120 to further prevent external light sources from affecting the accurate pulse measurement of the optical pulse wave imaging measuring instrument 100 degree.

The imaging module 200 is disposed on the inner side of the outer cover 120 and captures image information of the wrist area 11 at a direction angle. The imaging range of the imaging module 200 is approximately 50 mm 2 to 100 mm 2. The light source module 300 is arranged around the imaging module 200 and abuts against the cover 120, and the area to be measured (not shown in the figure) is located in the light shielding range of the cover 120 and is composed of the imaging module 200, the light source module 300, and The structured light projection device 700 is surrounded to provide sufficient light when the optical pulse wave image measuring instrument 100 of the present invention measures the pulse condition at the wrist area 11 of the subject. Preferably, in the embodiment shown in FIGS. 2 and 3, the number of light source modules 300 may be two, the two light source modules 300 are arranged around the imaging module 200 opposite to each other, and the two light source modules The 300 series are respectively pressed against the outer cover 120 for effective The size of the space in the outer cover 120 is maintained and sufficient light sources are provided for it, but the present invention is not limited to this.

Please refer to Figure 4, Figure 5 and Figure 6 at the same time. Figure 4 shows the imaging module 200, structured light projection device 700 and mobile module of the optical pulse wave image measuring instrument 100 of the embodiment in Figure 3 Fig. 5 is an enlarged schematic diagram of the structured light projection device 700 and the mobile module 800 of the optical pulse wave image measuring instrument 100 of the embodiment in Fig. 4, and Fig. 6 is a diagram showing the fifth The enlarged schematic diagram of the structured light projection device 700 of the optical pulse wave image measuring instrument 100 in the embodiment of FIG.

The structured light projection device 700 is arranged in the housing 120 and adjacent to the imaging module 200, and the structured light projection device 700 may include a structured light source 704, a digital micromirror device 720, and a mirror 730, and optical pulse wave images The measuring instrument 100 may further include a mobile module 800. In detail, the structured light source 704 will emit a light beam R, and the light beam R will be reflected by the mirror 730 to the digital micromirror device 720, and the digital micromirror device 720 will further process the optical properties of the light beam R to produce The structured light of the projection fringe P is then projected to the wrist area 11 by the digital micromirror device 720, and the imaging module 200 collects the light reflected by the wrist area 11 to facilitate subsequent analysis. The mobile module 800 is connected to the imaging module 200 and further connected to the structured light projection device 700, and the imaging module 200 and the structured light projection device 700 can move synchronously through the mobile module 800. Preferably, the moving module 800 may include a moving mechanism (not shown in the figure) to drive the imaging module 200 and the structured light projection device 700 to move in the vertical, horizontal, oblique, and rotational directions to move the image Module 200 And the structured light projection device 700 to a measurement position.

In addition, the other components of the optical pulse wave image measuring instrument 100 shown in FIGS. 2 and 3, such as the circuit module 400, the computing module 500, and the display module 600, are as described above, and will not be repeated here.

Hereinafter, referring to FIG. 7 and FIG. 8, the method of the optical pulse wave image measuring instrument 100 of the present invention for measuring the pulse condition will be described. Please refer to FIGS. 7 and 8. FIG. 7 is a schematic diagram showing the operating state of the optical pulse wave imaging measuring instrument 100 of the embodiment in FIG. 2, and FIG. 8 is a diagram showing another embodiment of the present invention. A flowchart of the pulse measurement method 900. The pulse measurement method 900 includes step 910, step 920, step 930, and step 940.

Step 910 is to perform a positioning adjustment step, which is to align the imaging module 200 with the wrist area 11 of the subject through the image positioning assist method, and adjust the imaging module 200 and the structured light projection device 700 to a certain amount Measure the position, where the wrist area 11 includes at least one of the three parts: inch, off, and ruler (not shown in the figure). In detail, when the subject wants to use the optical pulse wave imaging measuring instrument 100 of the present invention for pulse condition measurement, the subject will first place the palm of the hand up between the base 110 and the outer cover 120 to shield the light. Place the wrist area 11 on the pillow 111 of the base 110 to position the wrist area 11 to the correct measurement position, and adjust the height of the wrist area 11 of the subject to be flush with the heart At this time, the optical pulse wave image measuring instrument 100 will adjust the structured light source 704 of the structured light projection device 700 and the imaging module 200 at a spatial frequency to find the extension direction of the radial artery or peripheral blood vessel in the wrist area 11. And find the most obvious pulsation of the radial artery Places to locate the three positions of Cun, Guan and Chi.

Preferably, the positioning adjustment step can further drive the imaging module 200 and the structured light projection device 700 to perform synchronous displacements in the vertical direction, the horizontal direction, the tilt direction and the rotation direction through the moving module 800, so that the imaging module 200 and the structured light The projection device 700 moves to an optimal measurement position. In addition, the positioning adjustment step can adjust the positions of the imaging module 200 and the structured light projection device 700, so that the field of view of the imaging module 200 includes the three parts of the wrist area 11, namely, the inch, the off, and the feet, so as to simultaneously align the inch and off. Measure the pulse condition at the three parts of the ruler. Preferably, the wavelength range of the light source spectrum of the aforementioned structured light projection device 700 is visible light (wavelength range of 400nm-700nm) to near-infrared light (wavelength range of 700nm-1000nm). Specifically, the image positioning assistance method uses skin surface texture characteristics and structured light modulation to resolve height information to detect the characteristics of the wrist area 11, and uses an image sensor and the light source spectrum of the structured light projection device 700 for image positioning. To find out the position of the juncture, the place where the juncture extends about 10mm from the palm to the palm of the blood vessel is called the inch, and the place where the juncture extends about 10mm from the elbow along the direction of the blood vessel is called the ruler. The sensor can be an RGB sensor, but the invention is not limited to this.

Step 920 is a shooting step, which uses the imaging module 200 to capture image information of the wrist area 11, where the image information of the wrist area 11 includes the diameter width deformation data of the blood vessel and the height direction deformation data of the blood vessel or surrounding tissues Deformation data. In detail, the shooting step is to capture different measurement points of the wrist area 11 in different spaces by using the structured light source 704 and the imaging module 200 with a frequency conversion rate of 0.0142 mm ^-1 to 0.5 mm ^-1 . Frequency modulation image, where the structured light spatial frequency can include the lowest frequency to zero (that is, the light source does not contain structured light components) modulation image, and the highest spatial frequency modulation that can be resolved by the imaging module 200 image.

In addition, the synchronous high-speed photography method may include the step of synchronously updating the structured light source 704 and the imaging module 200, wherein the synchronous update rate of the structured light source 704 and the imaging module 200 satisfies the sampling of the Nyquist Theorem. The frequency is about 120FPS (Frame per Second) to a sampling frequency above 240FPS to avoid the phenomenon of pulse wave aliasing.

Step 930 is to perform a calculation step, which uses the calculation module 500 to analyze the image information to obtain a calculation result. In detail, the computing module 500 first calculates the degree of curvature of the structured light projection fringe P modulated by the wrist region 11, and then uses the computing module 500 to demodulate the projection fringe using a non-contact spatial frequency domain image demodulation and transformation algorithm The degree of curvature of P obtains the phase information of the wrist area 11, and converts the aforementioned phase information into blood vessel diameter width deformation data and blood vessel height direction deformation data or surrounding tissue deformation data, and analyzes blood vessel hemodynamic changes The diameter width and height direction of the blood vessel or the strain of the surrounding tissues caused by the pressure waveform change to obtain the position of the radial artery or peripheral blood vessel, the depth of the blood vessel, etc., to reconstruct the blood vessel distribution and unit time in the wrist area 11 The calculation result of the change of the pulse condition within.

Step 940 is a comparison step, which uses the arithmetic module 500 to compare the foregoing calculation result with a pulse classification data set. To output the pulse measurement result of one of the subjects. In detail, the pulse condition classification data set includes six categories of floating, sinking, imaginary, real, late, and number, a total of 28 pulse characteristics, and the calculation module 500 will compare the calculation results with the aforementioned 28 pulse characteristics. Compare to provide the corresponding pulse measurement results.

To sum up, the optical pulse wave image measuring instrument of the present invention uses the imaging module to automatically capture the image information of the subject’s wrist area, and performs calculation and analysis through the calculation module to further visualize the pulse information, and The pulse measurement method and its results can be standardized at the same time, to avoid the result error caused by the conventional use of palpation or pressure pulse detection. Furthermore, the pulse condition measurement method of the present invention applies non-contact spatial frequency domain imaging technology to pulse condition measurement, and automatically captures the image information and calculation of the pulse condition, and compares the result with the pulse condition classification data set , To assist Chinese medicine practitioners in pulse detection and diagnosis, and provide an objective and accurate pulse measurement result.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention. Anyone familiar with the art can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection of the present invention The scope shall be subject to those defined in the attached patent scope.

200: imaging module

202: Imaging Polarizer

204: imaging lens

206: Image Sensor

208: synchronization circuit

300: light source module

302: Light source polarizer

304: light source

308: synchronization circuit

400: circuit module

402: power supply circuit

404: control circuit

406: drive circuit

408: Data Transmission Circuit

500: Computing module

600: display module

700: Structured light projection device

702: light source polarizer

704: structured light source

708: synchronization circuit

800: mobile module

A: Area to be tested

Claims (18)

An optical pulse wave image measuring instrument, comprising: a base; an outer cover arranged on the base, and the outer cover is used to block interference light from a surrounding environment; an imaging module is arranged in the outer cover, and The imaging module is used to capture an image of an area to be measured, where the area to be measured includes a wrist area of a subject; a light source module arranged on a side of the imaging module; and a structured light The projection device is arranged in the outer cover; a circuit module is electrically connected to the imaging module and the light source module; a calculation module is connected to the circuit module with signals; and a display module is connected to the calculation module by signals group. The optical pulse wave image measuring instrument according to claim 1, wherein the wrist area includes three parts: cun, guan and chin. The optical pulse wave image measuring instrument according to claim 1, wherein a light source spectrum of the structured light projection device includes a visible light band to a near-infrared light band. The optical pulse wave image measuring instrument according to claim 1, further comprising: a mobile module connected to the imaging module, and the imaging module and the junction The light-structured projection device is synchronously displaced through the mobile module. The optical pulse wave image measuring instrument according to claim 1, wherein the structured light projection device includes a digital optical processing projector, and the digital optical processing projector includes a digital micromirror device and a digital micromirror device control module group. The optical pulse wave image measuring instrument according to claim 1, wherein the computing module includes a computer processor or a mobile device computing unit. A pulse waveform variable measurement method, comprising the following steps: performing a positioning adjustment step, which uses an image positioning auxiliary method to align an imaging module on a wrist area of a subject, and adjust the imaging Module and a structured light projection device to a measurement position, where the wrist area includes three parts: inch, close and ruler; performing a shooting step, which uses the imaging module to capture image information of the wrist area; and A calculation step is performed, which uses a calculation module to analyze the image information to obtain a pulse waveform transformation calculation result. The pulse waveform variable measurement method according to claim 7, wherein a light source spectrum of the structured light projection device includes a visible light band to a near-infrared light band. The pulse waveform variable measurement method according to claim 7, wherein the positioning adjustment step is to respectively modulate a light source spectrum of the structured light projection device and a light source spectrum of the imaging module at a spatial frequency, thereby positioning the wrist area. The pulse waveform variable measurement method according to claim 7, wherein the shooting step uses a synchronous high-speed photography method to capture modulated image information of a plurality of measurement points in the wrist area, wherein each of the measurement points has a Spatial frequency. The pulse waveform variable measurement method according to claim 7, wherein the calculation step uses the calculation module to analyze the image information of the wrist area with a non-contact spatial frequency domain image demodulation and transformation algorithm. The method for measuring pulse waveform variables according to claim 7, wherein the image information of the wrist area includes a blood vessel diameter width deformation data and a blood vessel height direction deformation data or a peripheral tissue deformation data. The pulse waveform variable measurement method according to claim 12, wherein the image information of the wrist area includes the height direction deformation data of the blood vessel or the surrounding tissue deformation data of at least one of the three parts of the inch, the Guan and the ulnar. The pulse waveform variable measurement method described in claim 12, which The image information in the wrist area includes a blood vessel deformation frequency data or a peripheral tissue deformation frequency data in at least one of the three parts of the inch, the Guan, and the ulnar. The pulse waveform variable measurement method according to claim 12, wherein the image information of the wrist area includes the range of each deformation of the blood vessel covering the three parts of the inch, Guan, and Chi, or each deformation of the peripheral tissue covering the inch, The range of the three parts of the ruler. The pulse waveform variable measurement method of claim 12, wherein the image positioning auxiliary method uses an image sensor and a light source spectrum of the structured light projection device to perform image positioning. The pulse waveform variable measurement method according to claim 12, wherein the image positioning auxiliary method uses a skin surface texture feature and a structured light modulation solution height information to locate the wrist area. The pulse waveform variable measurement method according to claim 11, wherein the non-contact spatial frequency domain image demodulation and transformation algorithm analyzes the pressure waveform change generated by the hemodynamic changes of a blood vessel in the wrist area The diameter, width and height of blood vessels or a strain of the surrounding tissue.

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