TWI714331B - Concentration module and pipe - Google Patents

Abstract

A concentration module including a first module, a second module, and a membrane is provided. The first module has a first inner surface, a first microfluidic channel, and a first fluid through hole. The first microchannel is located on the first inner surface, and the first fluid through hole extends through the first module to communicate with the first microfluidic channel. The second module has a second inner surface, a second microfluidic channel, and a second fluid through hole. The second microchannel is located on the second inner surface, and the second fluid through hole extends through the second module to communicate with the second microfluidic channel. The membrane is disposed between the first module and the second module. A pipe incorporating the concentration module is also provided.

Description

Concentrated membrane group and catheter

The present invention relates to a concentrated membrane set and catheter, and more particularly to a concentrated membrane set suitable for microanalysis and a catheter matched with it.

In the detection of general liquids, there are often troubles such as low concentration of the analyte, impurity interference, long pretreatment time, or cumbersome procedures. Therefore, how to provide an efficient and low-cost concentration device or method has become an urgent problem to be solved at present.

The invention provides a concentrated membrane group, which is suitable for microanalysis.

The concentrated membrane group of the present invention includes a first module, a second module and a membrane. The first module has a first inner surface, a first micro channel, and a first fluid through hole. The first micro channel is located on the first inner surface, and the first fluid through hole penetrates the first module to communicate with the first micro channel. The second module has a second inner surface, a second micro channel, and a second fluid through hole. The second micro flow channel is located on the second inner surface, and the second fluid through hole penetrates the second module to communicate with the second micro flow channel. The diaphragm is disposed between the first module and the second module.

In an embodiment of the present invention, the contour of the first micro-channel projected on the first inner surface substantially corresponds to the contour of the second micro-channel projected on the second inner surface.

In an embodiment of the present invention, the contour of the first micro-channel projected on the first inner surface is linear.

In an embodiment of the present invention, the first fluid through hole includes a first fluid inflow hole and a first fluid outflow hole, and the first fluid inflow hole and the first fluid outflow hole are respectively connected to two ends of the first microchannel .

In an embodiment of the present invention, the contour of the second microchannel projected on the second inner surface is linear.

In an embodiment of the present invention, the second fluid through hole includes a second fluid inflow hole and a second fluid outflow hole, and the second fluid inflow hole and the second fluid outflow hole are respectively connected to two ends of the second microchannel .

In an embodiment of the present invention, the first module further has a first outer surface opposite to the first inner surface, the first fluid through hole penetrates the first outer surface and the first inner surface, and the first fluid through hole is located on the The first outer aperture on an outer surface is larger than the first inner aperture on the first inner surface.

In an embodiment of the present invention, the first fluid through hole has a first side wall connecting the first outer surface and the first inner surface, and the first side wall includes at least a first inclined surface.

In an embodiment of the present invention, the second module further has a second outer surface opposite to the second inner surface, the second fluid through hole penetrates the second outer surface and the second inner surface, and the second fluid through hole is on the first The second outer aperture on the two outer surfaces is larger than the second inner aperture on the second inner surface.

In an embodiment of the present invention, the second fluid through hole has a second side wall connecting the second outer surface and the second inner surface, and the second side wall at least includes a second inclined surface.

In an embodiment of the present invention, the concentrated membrane group further includes a first pressing member and a second pressing member. The first pressing member is configured on the first module. The second pressing member is configured on the second module. The first pressing member and the second pressing member press and fix the first module, the second module and the diaphragm.

The present invention provides a catheter which is matched with the concentrated membrane assembly of the present invention.

The catheter of the present invention is suitable for being inserted into the first fluid through hole or the second fluid through hole of the concentrated membrane group.

In an embodiment of the invention, the catheter has a port. The port is adapted to be inserted into the first fluid through hole from the first outer surface, and the outer diameter of the port is larger than the first inner diameter.

In an embodiment of the invention, the catheter has a port. The port is adapted to be inserted into the second fluid through hole from the second outer surface, and the outer diameter of the port is larger than the second inner diameter.

In an embodiment of the present invention, the catheter further has an engaging portion, wherein the maximum outer diameter of the catheter at the engaging portion is greater than or equal to the first outer diameter.

In an embodiment of the present invention, the catheter further has an engaging portion, wherein the maximum outer diameter of the catheter at the engaging portion is greater than or equal to the second outer diameter.

Based on the above, the concentrated membrane set of the present invention is suitable for microanalysis and can have a thinner thickness. In addition, the extraction or concentration efficiency of the concentrated membrane assembly of the present invention can be better and the cost can be lower. In addition, the catheter of the present invention can be matched with the concentrated membrane assembly of the present invention.

The inventive concept can be embodied in many different forms and should not be regarded as limited to the exemplary embodiments presented herein. Rather, these exemplary embodiments are provided so that this disclosure will be complete and complete, and will fully express the concept of the present invention to those with ordinary knowledge in the technical field of the case. However, it should be understood that it is not intended to limit the inventive concept to the specific form disclosed, on the contrary, the inventive concept will cover all modifications, equivalents and alternatives falling within the spirit and scope of the inventive concept. Throughout the specification and the drawings, the same reference numerals represent the same elements. In the drawings, in order to make the concept of the present invention clear, the size of the structure is enlarged.

It should be understood that although the terms "first" and "second" or "A", "B", "C", and "D" herein can be used to describe different elements, these elements should not be used by these elements. Term limitation. These terms are only used to distinguish elements from each other. For example, the first element may be referred to as the second element, and, similarly, the second element may be referred to as the first element without departing from the protection scope of the inventive concept.

The term set used herein is only used for the purpose of describing particular embodiments and is not intended to limit the inventive concept. As used in the present invention, the singular form "one" will also include the plural form, unless explicitly specified otherwise herein. It will also be understood that the term "comprises", when used in this specification, specifies the presence of the described features, wholes, steps, operations, elements and/or elements, but does not exclude one or more features, wholes The existence or addition of, steps, operations, elements, elements, and/or groups thereof.

Unless otherwise defined, all terms (including technical terms and scientific terms) used herein have the same meanings commonly understood by those with ordinary knowledge in the technical field to which the present invention belongs. It will also be understood that terms (such as those defined in commonly used dictionaries) should be interpreted as having meaning consistent with the meaning in the relevant technical context, and should not be interpreted in an idealized or overly formal sense, unless This is clearly defined as such.

In the drawings, the illustrated shape can be modified as desired according to manufacturing technology and/or tolerances. Therefore, the exemplary embodiments should not be viewed as being limited to the specific shape of the illustrated area. During the manufacturing process, these shapes can be changed.

The term "and/or" as used in the present invention includes any and all combinations of one or more related listed items.

Fig. 1A is an exploded schematic diagram of a concentrated membrane assembly according to the first embodiment of the present invention. Fig. 1B is a partial schematic side view of a concentrated membrane assembly according to the first embodiment of the present invention. Fig. 1C is a partial schematic side view of a concentrated membrane group according to the first embodiment of the present invention. Fig. 1D is a schematic partial cross-sectional view of a concentrated membrane assembly according to the first embodiment of the present invention.

For example, FIG. 1B may be a schematic side view of the first inner surface 110a facing the first module 110 of the concentrated membrane group 100 in FIG. 1A, and FIG. 1C may be the second module facing the concentrated membrane group 100 in FIG. 1A A schematic side view of the second inner surface 120a of the 120, FIG. 1D is a cross-section of the concentrated membrane group 100 in FIG. 1A on the first fluid through hole 112 and the second fluid through hole 122 (for example, similar to the one in FIG. 1B A-A' section line and similar to the section on the B-B' section line in Figure 1C; or similar to the section line C-C' in Figure 1B and similar to the section line D-D' in Figure 1C Section) is a schematic cross-sectional view.

Please refer to FIGS. 1A to 1D, the concentrated membrane group 100 includes a first module 110, a second module 120 and a membrane 130. The first module 110 has a first inner surface 110 a, a first outer surface 110 b, a first micro channel 111 and a first fluid through hole 112. The first inner surface 110a is opposite to the first outer surface 110b. The first micro-channel 111 is located on the first inner surface 110a. The first fluid through hole 112 penetrates the first outer surface 110b and the first inner surface 110a of the first module 110 to communicate with the first microchannel 111 on the first inner surface 110a. The second module 120 has a second inner surface 120 a, a second outer surface 120 b, a second micro channel 121 and a second fluid through hole 122. The second inner surface 120a is opposite to the second outer surface 120b. The second micro flow channel 121 is located on the second inner surface 120a. The second fluid through hole 122 penetrates the second outer surface 120b and the second inner surface 120a of the second module 120 to communicate with the second microchannel 121 on the second inner surface 120a. The diaphragm 130 is disposed between the first inner surface 110 a of the first module 110 and the second inner surface 120 a of the second module 120.

In this embodiment, the first module 110 further has a first fixing through hole 117, and the second module 120 further has a second fixing through hole 127. The diaphragm 130 can be clamped or fixed to the first module by commonly used fixing parts (such as bolts, studs, screws, nuts, other common threaded connections and/or other suitable standard connections) 110 and the second module 120.

The material of the first module 110 may include metal, stainless steel, alloy (such as aluminum alloy) or plastic (such as polyetheretherketone (PEEK), acrylic or other suitable engineering plastics). The invention is not limited. The forming method of the first module 110 can be adjusted according to its material, which is not limited in the present invention.

In an embodiment, the first module 110 may be formed by stamping. For example, a plate can be stamped to form a through hole (such as a through hole that is the same or similar to the first fluid through hole 112 or the first fixed through hole 117) and a concave pattern (such as the same or similar In the concave pattern of the first micro-channel 111). Then, it may (but not limited to) go through appropriate steps (such as polishing) to form the first module 110. Therefore, the cost of the concentrated membrane group 100 can be lower.

In an embodiment, the first module 110 may be formed via a mold. For example, a plate can be stamped to form a through hole (such as a through hole that is the same or similar to the first fluid through hole 112 or the second fixed through hole 127) and/or a concave pattern (such as the same Or a module similar to the concave pattern of the first micro-channel 111). Then, it may (but not limited to) go through appropriate steps (such as polishing) to form the first module 110. Therefore, the cost of the concentrated membrane group 100 can be lower.

In an embodiment, the first module 110 may be formed via injection moulding. For example, uncured material may be injected into a mold, where the aforementioned mold may have a through hole (such as a through hole that is the same or similar to the first fluid through hole 112) and/or a concave pattern (such as: The convex pattern is the same or similar to the concave pattern of the first micro flow channel 111). Then, at least the material in the aforementioned mold is cured to form the first module 110. Therefore, the cost of the concentrated membrane group 100 can be lower.

The material or forming method of the second module 120 may be the same or similar to the material or forming method of the first module 110, so it will not be repeated here.

The membrane 130 may be a concentrated membrane, a filter membrane, or other suitable semipermeable membranes. In other words, in the use of the concentrated membrane assembly 100, the membrane 130 can be used to make the solute between the solution flowing through the first microchannel 111 and the solution flowing through the second microchannel 121 composed or The concentration is different.

In this embodiment, the contour of the first micro-channel 111 projected on the first inner surface 110a substantially corresponds to the contour of the second micro-channel 121 projected on the second inner surface 120a. In other words, after the first module 110, the second module 120 and the membrane 130 are combined to form the concentrated membrane group 100, the membrane 130 can completely cover the first microchannel 111 and the second module on the first module 110 The second micro flow channel 121 on the 120, and the first micro flow channel 111 on the first module 110 and the second micro flow channel 121 on the second module 120 can basically completely overlap.

In this embodiment, the contour of the first micro-channel 111 projected on the first inner surface 110a is linear. In other words, the contour of the first micro-channel 111 projected on the first inner surface 110a may not have a branch. In addition, the aforementioned line shape may include a straight line, a curved line, a broken line, and a combination of one or more of the above.

In one embodiment, the first fluid through hole 112 includes a first fluid inflow hole 118 and a first fluid outflow hole 119, and the first fluid inflow hole 118 and the first fluid outflow hole 119 are respectively connected to the first microchannel 111 The ends. In other words, in the application of the concentrated membrane assembly 100, the fluid can flow in from the first fluid inflow hole 118, and then flow out from the first fluid outflow hole 119 through the first microchannel 111. It is worth noting that the aforementioned application of the concentrated membrane assembly 100 is only an exemplary example, which is not limited in the present invention.

In this embodiment, the contour of the second micro-channel 121 projected on the second inner surface 120a is linear. In other words, the contour of the second micro-channel 121 projected on the second inner surface 120a may not have branches. In addition, the aforementioned line shape may include a straight line, a curved line, a broken line, and a combination of one or more of the above.

In one embodiment, the second fluid through hole 122 includes a second fluid inflow hole 128 and a second fluid outflow hole 129, and the second fluid inflow hole 128 and the second fluid outflow hole 129 are respectively connected to the second microchannel 121 The ends. In other words, in the application of the concentrated membrane assembly 100, the fluid can flow in from the second fluid inflow hole 128, and then flow out from the second fluid outflow hole 129 after passing through the second microchannel 121. It is worth noting that the aforementioned application of the concentrated membrane assembly 100 is only an exemplary example, which is not limited in the present invention.

In one of the exemplary applications of the concentrated membrane assembly 100, the original liquid can flow in from the first fluid inflow hole 118, then the concentrated liquid can flow out through the first fluid outflow hole 119, and the filtrate can flow out through the second fluid outflow hole 129. Therefore, the extraction or concentration efficiency of the concentrated membrane assembly 100 can be better.

It is worth noting that the application of the concentrated membrane assembly 100 is not limited to the fluid injected from the first fluid inflow hole 118 in the present invention. In other words, the first fluid inflow hole 118 may also inject fluid and gas from the first fluid inflow hole 118. For example, a catheter inserted into the first fluid inflow hole 118 (such as the catheter 800 of the subsequent embodiment) can be connected to one end of a T-shaped tube, and the other end of the aforementioned T-shaped tube can be filled with fluid, and the aforementioned T-shaped tube The other end of the gas can be supplied with gas at a specific time according to demand.

The concentrated liquid flowing out of the first fluid outflow hole 119 or the filtrate flowing out of the second fluid outflow hole 129 may flow to the analysis or detection device through a tube (such as the tube 800 in the subsequent embodiment), but the present invention is not limited thereto.

For example, the aforementioned stock solution may include A solute, B solute and C solvent, wherein the A solute can pass through the diaphragm 130 and the B solute cannot pass through the diaphragm 130. In this way, the filtrate can include solute A but not solute B, and the ratio of the concentration of solute A to the concentration of solute B in the concentrate (ie, concentration _{A solution} /concentration _{B solution} ) can be greater than the concentration of solute A in the original solution The ratio to the concentration of solute B.

In one of the exemplary application methods of the concentrated membrane assembly 100, compared to analyzing or detecting the solute concentration in the original solution, the analysis or detection of the solute concentration in the filtrate or concentrated solution can have a better signal-to-noise ratio (Signal-to-noise ratio). -noise ratio; SNR or S/N).

For example, in the above example, compared with analyzing or detecting the concentration of formazan in the stock solution, analyzing or detecting the concentration of formazan in the filtrate can have a better signal-to-noise ratio; or compared to analysis or detection The concentration of the solute in the original solution, analysis or detection of the concentration of the solute in the concentrated solution can have a better signal-to-noise ratio. The aforementioned analysis or detection can be adjusted according to the type or nature of the solute and/or the diaphragm 130, which is not limited in the present invention.

It is worth noting that, in the present invention, it is not limited to the application of the concentrated membrane assembly 100 that requires fluid injection from the second fluid inflow hole 128. In other words, the second fluid inflow hole 128 may also be sealed, let in gas, or used as a functional channel inlet for other purposes.

For example, in the above example, no fluid may be injected from the second fluid inflow hole 128, and the filtrate may at least flow out from the second fluid outflow hole 129. For another example, in the above example, the butane solvent can be injected from the second fluid inflow hole 128, and the solubility of the formazan solute in the butane solvent may be equal to or greater than the solubility of the formazan solute in the propylene solvent. For another example, in the above example, a dry gas (such as anhydrous nitrogen) can be introduced from the second fluid inflow hole 128.

In an embodiment not shown, at least one of the first module 110 or the second module 120 may be thermally coupled to a heat exchange device (such as a heater or a condenser), but the present invention Not limited to this. In other words, the first module 110 or the second module 120 can perform heat exchange with the heat exchange device.

In this embodiment, the opening of the first fluid through hole 112 on the first outer surface 110b has a first outer aperture 112b, and the opening of the first fluid through hole 112 on the first inner surface 110a has a first inner aperture 112a, The first outer aperture 112b is larger than the first inner aperture 112a. In an embodiment, the cross-sectional area of the first inner aperture 112 a is greater than or equal to the cross-sectional area of the first micro-channel 111.

In this embodiment, the first fluid through hole 112 has a first side wall 113 connecting the first outer surface 110b and the first inner surface 110a, and the first side wall 113 includes at least a first inclined surface (such as a first main inclined surface 114a). ). In this way, the catheter 800 can be inserted into the first fluid through hole 112 more easily.

In this embodiment, the opening of the second fluid through hole 122 on the second outer surface 120b has a second outer aperture 122b, and the opening of the second fluid through hole 122 on the second inner surface 120a has a second inner aperture 122a, The second outer aperture 122b is larger than the second inner aperture 122a. In an embodiment, the cross-sectional area of the second inner aperture 122 a is greater than or equal to the cross-sectional area of the second micro flow channel 121.

In this embodiment, the second fluid through hole 122 has a second side wall 123 connecting the second outer surface 120b and the second inner surface 120a, and the second side wall 123 includes at least a second inclined surface (eg, a second main inclined surface 124a). ). In this way, the catheter 800 can be inserted into the second fluid through hole 122 relatively easily.

The present invention also provides a catheter 800 suitable for the same or similar to the concentrated membrane group 100.

Please refer to FIGS. 1A to 1F, wherein FIGS. 1E to 1F are schematic partial cross-sectional views of a method of using a concentrated membrane assembly according to the first embodiment of the present invention. For example, FIG. 1E to FIG. 1F are partial cross-sectional schematic diagrams of combining the conduit 800 of the concentrated membrane set 100 and the concentrated membrane set 100 to use the concentrated membrane set 100. It is worth noting that, in this embodiment, the tube 800 is used in conjunction with the concentrated membrane group 100. In other embodiments or implementations not shown, the catheter 800 can also be used in conjunction with a concentrated membrane set similar to the concentrated membrane set 100 (for example, the concentrated membrane set 200 in the subsequent embodiment).

1A, FIG. 1D to FIG. 1F, the catheter 800 is adapted to be inserted into the first fluid through hole 112 or the second fluid through hole 122 of the concentrated membrane assembly 100. The catheter 800 has a port 810, and the port 810 has a port outer diameter 810a.

In this embodiment, the port 810 may be adapted to be inserted into the first fluid through hole 112 from the first outer surface 110b, and the port outer diameter 810a of the port 810 is larger than the first inner aperture 112a.

In this embodiment, the port 810 may be adapted to be inserted into the second fluid through hole 122 from the second outer surface 120b, and the port outer diameter 810a of the port 810 is larger than the second inner aperture 122a.

In this embodiment, the catheter 800 may further have an engaging portion 820, wherein there is an engaging distance 820c between the port 810 and the engaging portion 820. In addition, the catheter 800 has a maximum outer diameter 820a at the engaging portion 820. That is, the maximum outer diameter 820a is greater than the port outer diameter 810a.

In an embodiment, the material of the engaging portion 820 may be the same or similar to the material of the tube wall of the catheter 800. In other words, the engaging portion 820 may be a part of the tube wall that extends or protrudes outward, but the invention is not limited to this.

In this embodiment, the engagement distance 820c is smaller than the thickness 110T of the first module 110, and the maximum outer diameter 820a of the catheter 800 at the engagement portion 820 is greater than or equal to the first outer aperture 112b. In this way, after the port 810 of the catheter 800 can be inserted into the first fluid through hole 112 of the first module 110, the engaging portion 820 can be engaged in the first fluid through hole 112 for use in the concentrated membrane assembly 100. During the process (for example, during analysis or testing), the possibility of catheter 800 being detached may be reduced. But the present invention is not limited to this.

On the other hand, the engaging portion 820 that is engaged in the first fluid through hole 112 can be deformed according to the shape of the first fluid through hole 112, and it can be locked after the catheter 800 is inserted into the first fluid through hole 112. The joint 820 seals the side wall of the first fluid through hole 112. In this way, during the use of the concentrated membrane assembly 100 (for example, during analysis or testing), the possibility of liquid leakage may be reduced.

In this embodiment, the engagement distance 820c is smaller than the thickness 120T of the second module 120, and the maximum outer diameter 820a of the catheter 800 at the engagement portion 820 is greater than or equal to the second outer aperture 122b. In this way, after the port 810 of the catheter 800 can be inserted into the second fluid through hole 122 of the second module 120, the engaging portion 820 can be engaged in the second fluid through hole 122 for use in the concentrated membrane assembly 100 During the process (for example, during analysis or testing), the possibility of catheter 800 being detached may be reduced. But the present invention is not limited to this.

On the other hand, the engaging portion 820 that can be engaged in the second fluid through hole 122 can be deformed according to the shape of the second fluid through hole 122, and can be locked after the catheter 800 is inserted into the second fluid through hole 122. The joint 820 seals the side wall of the second fluid through hole 122. In this way, during the use of the concentrated membrane assembly 100 (for example, during analysis or testing), the possibility of liquid leakage may be reduced.

In an embodiment, the thickness of the engaging portion 820 may gradually increase in a direction away from the port 810. In this way, the engaging portion 820 can more easily seal the side wall of the fluid through hole (eg, the first fluid through hole 112 and/or the second fluid through hole 122).

Fig. 2 is a schematic partial cross-sectional view of a use mode of a concentrated membrane assembly according to a second embodiment of the present invention. The concentrated membrane set 200 in this embodiment is similar to the concentrated membrane set 100 of the first embodiment, and similar components are denoted by the same reference numerals, and have similar functions, materials, formation methods, or usage methods, and descriptions are omitted. In addition, FIG. 2 may be a schematic partial cross-sectional view of how the concentrated membrane group 200 is used.

Please refer to FIG. 2, the concentrated membrane group 200 includes a first module 110, a second module 120 and a membrane (not labeled, and may be the same or similar to the membrane 130 of the previous embodiment). The first module 110 has a first fluid through hole 212. The first fluid through hole 212 penetrates the first outer surface 110b and the first inner surface 110a of the first module 110 to communicate with the first microchannel 111 on the first inner surface 110a. The second module 120 has a second fluid through hole 222. The second fluid through hole 222 penetrates the second outer surface 120b and the second inner surface 120a of the second module 120 to communicate with the second microchannel 121 on the second inner surface 120a.

In this embodiment, the first fluid through hole 212 has a first side wall 213 connecting the first outer surface 110b and the first inner surface 110a, and the first side wall 213 includes a plurality of first inclined surfaces (such as the first main inclined surface 114a). And the first slope 214b). In this way, the catheter 800 can be inserted into the first fluid through hole 212 more easily.

In addition, the first slope 214b is connected to the first outer surface 110b. In this way, in this way, the engaging portion 820 of the conduit 800 can more easily seal the side wall of the first fluid through hole 212.

In this embodiment, the second fluid through hole 222 has a second side wall 223 connecting the second outer surface 120b and the second inner surface 120a, and the second side wall 223 includes a plurality of second inclined surfaces (such as the second main inclined surface 124a And the second slope 224b). In this way, the catheter 800 can be inserted into the second fluid through hole 222 more easily.

In addition, the second inclined surface 224b is connected to the second outer surface 120b. In this way, in this way, the engaging portion 820 of the conduit 800 can more easily seal the side wall of the second fluid through hole 222.

3A is an exploded schematic diagram of a concentrated membrane pack 100 according to the third embodiment of the present invention. 3B is a schematic partial cross-sectional view of a use mode of the concentrated membrane pack 100 according to the third embodiment of the present invention. The concentrated membrane set 300 in this embodiment is similar to the concentrated membrane set 100 of the first embodiment, and similar components are denoted by the same reference numerals, and have similar functions, materials, formation methods, or usage methods, and descriptions are omitted.

Referring to FIGS. 3A to 3B, the concentrated membrane set 300 includes a first module 110, a second module 120, a membrane 130, a first pressurizing member 340 and a second pressurizing member 350. The first pressing member 340 is disposed on the first module 110. The second pressing member 350 is disposed on the second module 120.

With commonly used fixing parts (such as bolts, studs, screws, nuts, other common threaded connections, and/or other suitable standard connections), the first module 110, the second module 120, and the The diaphragm 130 sandwiched between the first module 110 and the second module 120 is sandwiched or fixed between the first pressing member 340 and the second pressing member 350.

For example, the first pressing member 340 or the second pressing member 350 may have a pipe through hole 361 and a fixing through hole 362, the pipe 800 may pass through the pipe through hole 361, and the largest outer portion of the engaging portion 820 of the pipe 800 The diameter 820a may be larger than the aperture 361a of the conduit through hole 361. In this way, after the catheter 800 is passed through the catheter through hole 361 in the manner shown in FIG. 3B, the first pressing member 340 or the second pressing member 350 can contact and apply pressure to the engagement of the catheter 800 The first module 110 or the second module 120 is contacted by the engaging portion 820 of the tube 800 and pressure is applied to fix the first module 110, the second module 120 and the diaphragm 130. In addition, after the conduit 800 is inserted into the fluid through hole (such as the first fluid through hole 112 or the second fluid through hole 122), the engaging portion 820 can seal the side wall of the fluid through hole, which may reduce the possibility of liquid leakage.

4 is a schematic partial cross-sectional view of a use mode of a concentrated membrane pack 100 according to a fourth embodiment of the present invention. The concentrated membrane set 400 of this embodiment is similar to the concentrated membrane set 100 of the third embodiment, and similar components are denoted by the same reference numerals, and have similar functions, materials, formation methods, or usage methods, and descriptions are omitted.

4, the conduit through hole 461 of the first pressurizing member 340 or the second pressurizing member 350 has a zigzag pattern, the conduit 800 may further have a fixing part 831, and the fixing part 831 of the conduit 800 may have a corresponding conduit through hole The zigzag pattern of 461. In this way, the catheter 800 can be fixed to the first module 110 or the second module 120.

In an embodiment, the zigzag pattern of the conduit through hole 461 and the zigzag pattern of the fixing portion 831 can be regarded as corresponding threads. In this way, the depth of insertion of the catheter 800 into the first fluid through hole 112 or the second fluid through hole 122 can be adjusted by the thread.

In this embodiment, the maximum outer diameter 820a of the engaging portion 820 of the catheter 800 may be smaller than the aperture 461a of the catheter through hole 461. In an embodiment, the module (such as the first module 110 or the second module 120), the conduit 800, and the pressure member (such as the first pressure member 340 or the second pressure member 350) can be assembled as follows: First assemble the conduit 800 and the pressurizing member; then, assemble the pressurizing member and the module, and insert the conduit 800 into the fluid through hole (for example, the first fluid through hole 112 or the second fluid through hole 122). In an embodiment, the module (such as the first module 110 or the second module 120), the conduit 800, and the pressure member (such as the first pressure member 340 or the second pressure member 350) can be assembled as follows: First assemble the pressurizing member and the module; then, insert the conduit 800 from the conduit through hole 461 of the pressurizing member into the fluid through hole of the module (for example, the first fluid through hole 112 or the second fluid through hole 122).

FIG. 5 is a schematic partial cross-sectional view of a use mode of a concentrated membrane pack 500 according to a fifth embodiment of the present invention. The concentrated membrane set 500 of this embodiment is similar to the concentrated membrane set 400 of the fourth embodiment, and similar components are denoted by the same reference numerals, and have similar functions, materials, formation methods, or usage methods, and descriptions are omitted.

In this embodiment, the maximum outer diameter 820a of the engaging portion 820 of the catheter 800 may be smaller than the minimum aperture 561a of the catheter through hole 561, and the maximum outer diameter 832a of the fixing portion 832 may be greater than the minimum aperture 561a of the catheter through hole 561. In an embodiment, the module (such as the first module 110 or the second module 120), the conduit 800, and the pressure member (such as the first pressure member 340 or the second pressure member 350) can be assembled as follows: First assemble the conduit 800 and the pressurizing member; then, assemble the pressurizing member and the module, and insert the conduit 800 into the fluid through hole (for example, the first fluid through hole 112 or the second fluid through hole 122).

In summary, the concentrated membrane assembly of the present invention uses microfluidic channels and membranes for concentration or solute selection. Therefore, it can be used for trace analysis or detection of solute concentration in filtrate or concentrate. Good signal-to-noise ratio. In addition, the extraction or concentration efficiency of the concentrated membrane assembly of the present invention can be better and the cost can be lower. In addition, the thickness of the concentrated membrane group may also be thin. On the other hand, the catheter of the present invention can also be combined with the concentrated membrane set of the present invention. In addition, through the cooperation of the catheter and the concentrated membrane assembly of the present invention, the possibility of liquid leakage can be reduced.

100, 200, 300, 400, 500: concentrated membrane group

110: The first module

110T: thickness

110a: first inner surface

110b: First outer surface

111: The first micro channel

112, 212: first fluid through hole

113, 213: first side wall

114: first slope

114a: First main slope

214b: first slope

112a: first inner aperture

112b: first outer aperture

117: The first fixed through hole

118: First fluid inflow hole

119: First fluid outflow hole

120: second module

120T: thickness

120a: second inner surface

120b: second outer surface

121: second micro channel

122, 222: second fluid through hole

123, 223: second side wall

124: second slope

124a: The second main slope

224b: second slope

122a: second inner aperture

122b: second outer aperture

127: second fixed through hole

128: Second fluid inflow hole

129: Second fluid outflow hole

130: diaphragm

340: The first press

350: The second pressurized part

361, 461, 561: duct through hole

361a, 461a: aperture

561a: minimum aperture

362: fixed through hole

800: Catheter

810: port

810a: port outer diameter

820: Snap

820a: Maximum outer diameter

820c: engagement distance

831, 832: fixed part

832a: Maximum outer diameter

Fig. 1A is an exploded schematic diagram of a concentrated membrane assembly according to the first embodiment of the present invention. Fig. 1B is a partial schematic side view of a concentrated membrane assembly according to the first embodiment of the present invention. Fig. 1C is a partial schematic side view of a concentrated membrane group according to the first embodiment of the present invention. Fig. 1D is a schematic partial cross-sectional view of a concentrated membrane assembly according to the first embodiment of the present invention. 1E to 1F are schematic partial cross-sectional views of a use mode of a concentrated membrane assembly according to the first embodiment of the present invention. Fig. 2 is a schematic partial cross-sectional view of a use mode of a concentrated membrane assembly according to a second embodiment of the present invention. Fig. 3A is an exploded schematic diagram of a concentrated membrane assembly according to the third embodiment of the present invention. 3B is a schematic partial cross-sectional view of a use mode of a concentrated membrane assembly according to the third embodiment of the present invention. 4 is a schematic partial cross-sectional view of a use mode of a concentrated membrane assembly according to a fourth embodiment of the present invention. Fig. 5 is a schematic partial cross-sectional view of a use mode of a concentrated membrane group according to a fifth embodiment of the present invention.

100: Concentrated membrane group

110: The first module

110a: first inner surface

110b: First outer surface

111: The first micro channel

112: First fluid through hole

117: The first fixed through hole

118: First fluid inflow hole

119: First fluid outflow hole

120: second module

120a: second inner surface

120b: second outer surface

121: second micro channel

122: second fluid through hole

127: second fixed through hole

128: Second fluid inflow hole

129: Second fluid outflow hole

130: diaphragm

Claims (9)

A concentrated membrane group, comprising: a first module with a first inner surface, a first micro-channel and a first fluid through hole, wherein the first micro-channel is located on the first inner surface, and the first A fluid through hole penetrates the first module to communicate with the first micro channel; the second module has a second inner surface, a second micro channel, and a second fluid through hole, wherein the second micro channel The channel is located on the second inner surface, and the second fluid through hole penetrates the second module to communicate with the second micro-channel; and the diaphragm is arranged on the first module and the first module Between the two modules, wherein: the first module further has a first outer surface opposite to the first inner surface, and the first fluid through hole penetrates the first outer surface and the first inner surface, And the first outer hole diameter of the first fluid through hole on the first outer surface is larger than the first inner hole diameter on the first inner surface; or the second module has a larger diameter relative to the second The second outer surface of the inner surface, the second fluid through hole penetrates the second outer surface and the second inner surface, and the second fluid through hole is located on the second outer surface of the second outer surface. The aperture is larger than the second inner aperture on the second inner surface. The concentrated membrane set according to the first item of the scope of patent application, wherein the contour of the first microchannel projected on the first inner surface substantially corresponds to the projection of the second microchannel on the The contour on the second inner surface. The concentrated membrane set according to the first item of the scope of patent application, wherein: the contour of the first micro-channel projected on the first inner surface is a line Or the contour of the second micro-channel projected on the second inner surface is linear. The concentrated membrane set according to the third of the scope of patent application, wherein: the first fluid through hole includes a first fluid inflow hole and a first fluid outflow hole, and the first fluid inflow hole and the first fluid Outflow holes are respectively connected to both ends of the first microchannel; or the second fluid through hole includes a second fluid inflow hole and a second fluid outflow hole, and the second fluid inflow hole and the second fluid The fluid outflow holes are respectively connected to the two ends of the second micro channel. The concentrated membrane set according to the first patent application, wherein: the first fluid through hole has a first side wall connecting the first outer surface and the first inner surface, and the first side wall includes at least A first inclined surface; or the second fluid through hole has a second side wall connecting the second outer surface and the second inner surface, and the second side wall includes at least a second inclined surface. The concentrated membrane assembly described in item 1 of the scope of the patent application further includes: a first pressurizing member disposed on the first module; and a second pressurizing member disposed on the second module, wherein The first pressing member and the second pressing member press and fix the first module, the second module, and the diaphragm. A catheter matching the concentrated membrane set of any one of claims 1 to 6, the catheter is suitable for being inserted into the first fluid through hole or the second fluid through hole of the concentrated membrane set. A catheter matching the concentrated membrane set of any one of claims 1 to 6, having a port, wherein: the port is adapted to be inserted into the first fluid through hole from the first outer surface, and the port of the port The outer diameter is greater than the first inner diameter; or the port is adapted to be inserted into the second fluid through hole from the second outer surface, and the outer diameter of the port is greater than the second inner diameter. The catheter described in item 8 of the scope of the patent application further has an engaging portion, wherein: the maximum outer diameter of the catheter at the engaging portion is greater than or equal to the first outer aperture; or the catheter is attached to the The maximum outer diameter of the engaging portion is greater than or equal to the second outer diameter.

Images