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TWI799814B - 噁唑啶酮化合物及其做為抗菌劑之使用方法 - Google Patents

噁唑啶酮化合物及其做為抗菌劑之使用方法 Download PDF

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Publication number
TWI799814B
TWI799814B TW110109522A TW110109522A TWI799814B TW I799814 B TWI799814 B TW I799814B TW 110109522 A TW110109522 A TW 110109522A TW 110109522 A TW110109522 A TW 110109522A TW I799814 B TWI799814 B TW I799814B
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TW
Taiwan
Prior art keywords
methods
antibacterial agent
oxazolidinone compound
oxazolidinone
compound
Prior art date
Application number
TW110109522A
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English (en)
Other versions
TW202200573A (zh
Inventor
布蘭登 Ｍ 科維力
菲利普 納什莫
大衛 Ｂ 歐森
鈴木隆夫
利湖 楊
余嵐英
Original Assignee
美商默沙東有限責任公司
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Publication of TW202200573A publication Critical patent/TW202200573A/zh
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Publication of TWI799814B publication Critical patent/TWI799814B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
TW110109522A 2020-03-20 2021-03-17 噁唑啶酮化合物及其做為抗菌劑之使用方法 TWI799814B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WOPCT/CN2020/080359 2020-03-20
PCT/CN2020/080359 WO2021184339A1 (en) 2020-03-20 2020-03-20 Oxazolidinone compound and methods of use thereof as an antibacterial agent

Publications (2)

Publication Number Publication Date
TW202200573A TW202200573A (zh) 2022-01-01
TWI799814B true TWI799814B (zh) 2023-04-21

Family

ID=75478174

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110109522A TWI799814B (zh) 2020-03-20 2021-03-17 噁唑啶酮化合物及其做為抗菌劑之使用方法

Country Status (21)

Country Link
US (1) US12435077B2 (zh)
EP (1) EP4121058A1 (zh)
JP (1) JP7241984B2 (zh)
KR (1) KR102824010B1 (zh)
CN (1) CN115605208A (zh)
AR (1) AR121598A1 (zh)
AU (1) AU2021239937B2 (zh)
BR (1) BR112022018674A2 (zh)
CA (1) CA3172304A1 (zh)
CL (1) CL2022002511A1 (zh)
CO (1) CO2022013595A2 (zh)
CR (1) CR20220472A (zh)
EC (1) ECSP22073580A (zh)
GE (1) GEP20247641B (zh)
IL (1) IL296401A (zh)
MX (1) MX2022011431A (zh)
NZ (1) NZ792402A (zh)
PE (1) PE20230002A1 (zh)
PH (1) PH12022552495A1 (zh)
TW (1) TWI799814B (zh)
WO (2) WO2021184339A1 (zh)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
CA3183397A1 (en) 2020-06-18 2021-12-23 Daryl C. Drummond Oxazolidinone compounds, liposome compositions comprising oxazolidinone compounds and methods of use thereof
US20240390366A1 (en) * 2021-11-30 2024-11-28 Mannkind Corporation Formulation and method for topical treatment of mycobacterium ulcerans in buruli ulcers
EP4296674A1 (en) 2022-06-20 2023-12-27 Université Toulouse III - Paul Sabatier Innovative molecules decreasing virulence of mycobacterium for the treatment of tuberculosis
WO2024035618A1 (en) * 2022-08-10 2024-02-15 Merck Sharp & Dohme Llc Processes for preparing oxazolidinone compounds

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MX2022011431A (es) 2022-10-03
AU2021239937A1 (en) 2022-10-06
CA3172304A1 (en) 2021-09-23
AU2021239937B2 (en) 2023-10-26
CO2022013595A2 (es) 2023-02-16
ECSP22073580A (es) 2022-11-30
WO2021184339A1 (en) 2021-09-23
US20240208958A1 (en) 2024-06-27
WO2021188606A1 (en) 2021-09-23
TW202200573A (zh) 2022-01-01
CR20220472A (es) 2022-11-14
KR20220156577A (ko) 2022-11-25
GEP20247641B (en) 2024-07-10
CN115605208A (zh) 2023-01-13
JP2023507683A (ja) 2023-02-24
CL2022002511A1 (es) 2023-03-24
US12435077B2 (en) 2025-10-07
PE20230002A1 (es) 2023-01-05
IL296401A (en) 2022-11-01
EP4121058A1 (en) 2023-01-25
NZ792402A (en) 2025-09-26
BR112022018674A2 (pt) 2022-11-01
AR121598A1 (es) 2022-06-22
KR102824010B1 (ko) 2025-06-20
JP7241984B2 (ja) 2023-03-17
PH12022552495A1 (en) 2024-03-25

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