TWI771388B - composition for disinfection - Google Patents

Abstract

An object of the present invention is to provide a disinfectant that is used for sterilization of fingers, etc., by incorporating chondroitin sulfate or chondroitin sulfate as a moisturizing agent to improve moisturizing properties, while preventing bacteria or viruses from entering and causing infection The purpose is to make the composition for disinfection in which chondroitin sulfate or chondroitin sulfate is uniformly present in the composition while the hand is rough. The solution of the present invention can be solved by the following disinfection composition, which contains 20 to 60% by weight of lower alcohol with 1 to 3 carbon atoms, 40 to 65% by weight of water, chondroitin sulfate or Chondroitin sulfate is characterized by 0.006-1 wt%, and contains oil components, thickeners and surfactants, and the viscosity at 25°C is 50-300Pa･s.

Description

composition for disinfection

The present invention relates to a disinfectant composition used for sterilization of fingers, etc., and has excellent moisturizing properties and properties.

Conventionally, it is generally known that lower alcohols having 1 to 3 carbon atoms such as ethanol and isopropanol have a sterilizing effect on bacteria or viruses by destroying the cell membrane of bacteria or the outer membrane of viruses, or by coagulating proteins such as enzymes, and are widely used. Disinfectants blended with these lower alcohols. However, in general, a disinfectant blended with a lower alcohol such as ethanol and isopropyl alcohol has a problem of causing roughness of the user's hand when it is used for disinfecting fingers, for example. Rough hands refer to a state in which the stratum corneum and sebum film are removed, and the stratum corneum is insufficient, and the skin barrier function is lost. This state can be said to be susceptible to infection by bacteria or viruses invading from the barrier defect. From these viewpoints, even if a lower alcohol is blended, there is still a need for a disinfectant excellent in moisturizing properties that can prevent hand roughness, that is, a defect in the skin barrier function.

For example, Patent Document 1 discloses a disinfectant containing carboxyvinyl polymers, natural polysaccharides, etc., fatty acid esters, and lower alcohols, and the blending ratio of the lower alcohols is 20 to 50% by weight. With the carboxyvinyl polymer blended with the adhesive, when the finger is rubbed, the polymer component is precipitated (resinized) on the finger due to the salt of the finger, so-called scaly slag. Incorporates natural polysaccharides or derivatives thereof as features. [Prior Art Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Application Laid-Open No. 10-130173

[The problem to be solved by the invention]

However, in the composition described in the Example of patent document 1, there exists a problem that the moisturizing property is not enough.

In addition, although the invention described in Patent Document 1 discloses the use of sodium chondroitin sulfate as a natural polysaccharide, in practice, when sodium chondroitin sulfate is blended, it may not be uniformly present, such as insolubility due to the balance of other components in the composition. Problems in composition.

Therefore, in the present invention, there is provided a disinfectant used for sterilization of fingers, etc., by blending chondroitin sulfate or chondroitin sulfate as a moisturizing agent, to improve moisturizing properties, while preventing bacteria or viruses from entering and becoming infection. The reason is that the hand is rough, and the purpose is to make chondroitin sulfate or chondroitin sulfate uniformly present in the composition for disinfection. [means to solve the problem]

[1] That is, the present invention is a composition for disinfection, characterized by containing 20 to 60% by weight of a lower alcohol having 1 to 3 carbon atoms, 40 to 65% by weight of water, and 0.006 to 0.006% of chondroitin sulfate or chondroitin sulfate. 1% by weight.

[2] Further, the disinfecting composition according to the above [1], which contains a fat and oil component, a tackifier and a surfactant, and has a viscosity of 50 to 300 Pa·s at 25°C.

[3] Further, the disinfecting composition according to the above [1] or the above [2], wherein the thickener is at least one selected from the group consisting of carboxyvinyl polymers and cellulose derivatives.

[4] Further, the disinfecting composition according to any one of the above [1] to the above [3], wherein the surfactant contains a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol.

[5] Further, the disinfecting composition according to any one of the above [1] to the above [4], which contains a composition selected from the group consisting of benzethonium chloride and benzalkonium chloride. ), chlorhexidine gluconate (chlorhexidine gluconate), povidone iodine, isopropyl methyl phenol, chloroxylenol at least one of the disinfection components. [Effect of invention]

According to the present invention, as a disinfectant used for sterilization of fingers, etc., by incorporating chondroitin sulfate or chondroitin sulfate as a moisturizing agent, the moisturizing property can be improved, and the intrusion of bacteria or viruses can be prevented and the hands that become the cause of infection can be prevented. Rough, edge makes chondroitin sulfate or chondroitin sulfate evenly present in the composition.

Hereinafter, embodiments of the disinfecting composition of the present invention will be described in detail. Also, when there is a label indicating a range in the description, it includes an upper limit and a lower limit.

The lower alcohols having 1 to 3 carbon atoms in the present invention are alcohols having 1 to 3 carbon atoms, such as methanol, ethanol, and isopropanol. By using this lower alcohol, the bacteria or viruses can be killed by the destruction of the bacterial cell membrane or the outer membrane of the virus or the coagulation of proteins such as enzymes, and the adverse effects on the human body of the diseases caused by the bacteria or viruses can be prevented. .

The content ratio of the composition for disinfection in the lower alcohol having 1 to 3 carbon atoms is preferably 20 to 60% by weight. When the content exceeds 60% by weight, chondroitin sulfate or chondroitin sulfate cannot be uniformly dissolved or dispersed. In addition, when the content ratio is less than 20% by weight, bacteria and viruses cannot be sufficiently sterilized, and other bactericidal components and the like must be added in order to exhibit the desired effect.

The chondroitin sulfate or chondroitin sulfate of the present invention is a compound of a sugar chain-bonded sulfuric acid having a di-saccharide composed of D-gluconic acid and N-acetyl-D-galactosamine as a constituent unit or Its sulfuric acid hydrogen is replaced by sodium, potassium, etc. salt, blended as a humectant. By incorporating chondroitin sulfate or chondroitin sulfate, the moisturizing properties of the disinfecting composition, especially the moisturizing properties over time, are improved.

The content ratio of the composition for disinfection in chondroitin sulfate or chondroitin sulfate is preferably 0.006 to 1% by weight. When the content ratio is within the above-mentioned range, the disinfecting composition can be uniformly dissolved or dispersed, and the moisturizing property can be maintained, and the user's hands can be prevented from being rough.

The fats and oils of the present invention are divided into liquid or solid fats and oils at room temperature of 20°C to 25°C. Blending can be carried out if necessary. When the composition for disinfection is used by emulsifying the oil and fat content, the oil and fat content can be diffused to the skin of fingers and the like, thereby suppressing volatilization of moisture from the skin, thereby preventing rough hands and the like. As the oil and fat component, both natural products and synthetic products can be used, and as the natural product, either plant-derived or animal-derived fats and oils can be used.

As the fats and oils, for example, preferred are hydrocarbons such as free paraffin, light free paraffin, squalane, isopropyl palmitate, octyl palmitate, isopropyl myristate, isononyl isononanoate, 8 carbon atoms ~Middle-chain fatty acid triglycerides composed of fatty acids having 22 carbon atoms, ester oils such as tris(decanoyl/capric)glyceryl, myristyl alcohol (carbon number 14), cetyl alcohol (carbon number 16) , stearyl alcohol (carbon number 18), cetearyl alcohol (mixture of carbon number 16 and 18), behenyl alcohol (carbon number 22), isostearyl alcohol (carbon number 18), Fats such as saturated monohydric alcohols such as 2-hexyldecanol (carbon number 16), 2-octyldodecanol (carbon number 20), or unsaturated monohydric alcohols such as oleyl alcohol (carbon number 18) Alcohols, soybean oil, safflower oil, grapeseed oil, rosehip oil, sunflower oil, evening primrose oil, cottonseed oil, sesame oil, wheat germ oil, almond oil, etc. As non-drying oils, olive oil and camellia oil are preferred , camellia oil, castor oil, peanut oil, avocado oil, macadamia oil, hazelnut oil, meadowsweet oil, jojoba oil, etc., as essential oils, preferably eucalyptus oil, peppermint oil, Roman chamomile oil, etc. (vegetable oil ). These oils and fats can be used alone or in combination of two or more.

As a content rate of the composition for disinfection in fats and oils, it is preferable that it is 0.5 to 20 weight%, and it is more preferable that it is 1.0 to 10 weight%. When the content ratio is in the above-mentioned range, the user's hand can be prevented from being rough during use.

The tackifier in the present invention is a component that increases the viscosity of the disinfecting composition. Blending can be carried out if necessary. By using a thickening agent, the viscosity of the composition for disinfection can be raised to the predetermined viscosity.

As the tackifier, for example, carboxyvinyl polymers of cross-linked polyacrylic acid, cellulose derivatives such as carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, guar Gum erba, gum arabic, sodium alginate, propylene glycol alginate, ethyl cellulose, sodium polyacrylate, cyclodextrin, etc., among them, carboxyvinyl polymers and carboxymethyl cellulose are more preferable. These tackifiers may be used alone or in combination of two or more.

The content ratio of the disinfecting composition in the thickener is preferably 0.1 to 10% by weight, more preferably 0.2 to 7% by weight. When the content ratio is within the above-mentioned range, it can be adjusted to a desired viscosity for use.

The surfactant of the present invention is an ingredient for homogeneously mixing the disinfecting composition to stabilize the properties of a cream. Blending can be carried out if necessary. By using a surfactant, it is possible to prevent separation of lower alcohols having 1 to 3 carbon atoms, etc., which are components of the disinfection composition.

As a surfactant, a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and a nonionic surfactant are mentioned, for example. The cationic surfactant is a surfactant that becomes a cation when dissociated in water, and is preferably an alkyl trimethyl ammonium salt, an alkyl dimethyl ammonium salt, an alkyl benzyl dimethyl ammonium salt, or the like. Among them, the alkyl group preferably has 12 to 22 carbon atoms, and the counter anion is preferably a chloride ion, a hydroxide ion, a bromide ion, or the like.

Furthermore, anionic surfactants are surfactants that become anions when dissociated in water, such as fatty acid salts, monoalkyl sulfates, alkylpolyoxyethylene sulfates, alkylbenzenesulfonates, and monoalkylphosphoric acids are preferred salt etc. Among them, the alkyl group preferably has 12 to 22 carbon atoms, and the counter cation is preferably sodium ion, potassium ion, calcium ion, magnesium ion, and the like.

In addition, the amphoteric surfactant has both an anionic site and a cationic site in the molecule, and becomes a cationic, anionic, and cationic and anionic amphoteric surfactant according to the pH of the solution, such as alkyl dimethyl methyl amine oxides, alkyl carboxybetaines, etc. Among them, the alkyl group preferably has 12 to 22 carbon atoms.

In addition, the nonionic surfactant is an active agent having a hydrophilic part in which the hydrophilic part is not ionized, for example, a polyoxyethylene alkyl ether such as polyoxyethylene cetyl ether or polyoxyethylene stearyl ether is preferred , glycerol fatty acid ester or sorbitol fatty acid ester, polyol fatty acid ester of sucrose fatty acid ester, fatty acid ester of polyoxyethylene addition polyol, fatty acid diethanolamide, etc. Among the above-mentioned nonionic surfactants, the HLB calculated by Griffin's formula is more preferably 3-17. When the above-mentioned nonionic surfactant has a polyoxyethylene skeleton, the added molar number of oxyethylene can be appropriately changed. When HLB is a nonionic surfactant in the said range, the storage stability of the composition for disinfection is excellent, and specifically, even if time passes, it does not cause a separation etc. and can maintain a creamy state. In addition, although these surfactants may be used alone or in combination of two or more, it is preferable to combine the surfactants of HLB3-6 and the surfactants of HLB12-17.

In addition, water is blended in the disinfecting composition of the present invention. The water is preferably water compliant with the Japanese Pharmacopoeia, such as tap water, well water, or other normal water, and any of distillation, ion exchange treatment by ion exchange membrane, and ultrafiltration treatment by ultrafiltration membrane, Or purified water of normal water is treated by a combination of these, and it is preferably sterilized purified water of purified water treated by sterilization by heating or the like. In addition, the mixing ratio of the above-mentioned water is to remove the residues of ethanol, chondroitin sulfate or chondroitin sulfate used in the present invention, and when mixing thickeners, surfactants, etc., it is preferable to remove these residues. It is 40 to 65 weight%, More preferably, it is 42 to 63 weight%.

In addition, the disinfecting composition of the present invention may be mixed with disinfecting components if necessary. Disinfection ingredients are blended to disinfect bacteria or viruses that cannot be adequately disinfected by lower alcohols having 1 to 3 carbon atoms. As the disinfecting component, for example, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, povidone iodine, isopropylmethylphenol, chloroxylenol, etc. are preferable, and benzethonium chloride is more preferable. Ammonium. In addition, these disinfecting components can be used only 1 type or in combination of 2 or more types.

When the viscosity of the disinfecting composition of the present invention can be increased by admixing a tackifier, the viscosity of the disinfecting composition of the present invention is the Brookfield-type rotational viscometer type B described in JIS K7117-1. In the measurement (manufactured by Toki Sangyo Co., Ltd., trade name "TVB-10M"), it is preferably 50 to 300 Pa･s, more preferably 100 to 250 Pa･s at 25°C. When the viscosity of the disinfectant composition is within this range, even if it is adhered to the skin of fingers, etc., it does not fall off instantaneously, and it is easy to spread when applied.

Chondroitin sulfate or other moisturizing agents other than chondroitin sulfate may be further incorporated into the disinfecting composition of the present invention. As other humectants, for example, glycerin, polyglycerol, propylene glycol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, polyethylene glycol, maltitol, and sorbose are preferred. Polyols such as alcohol, sodium hyaluronate, urea, sodium lactate, trimethylglycine, etc.

In addition to the above-mentioned components, antioxidants such as tocopherol, vitamin C, BHT, etc., pH adjusters, buffers, fragrances, pigments, etc. may be incorporated into the disinfecting composition of the present invention, if necessary. [Example]

[Example 1] A composition containing 30 parts by weight of ethanol, 1 part by weight of sodium chondroitin sulfate, and 100 parts by weight of water remaining was adjusted and mixed well to prepare a composition for disinfection.

[Example 2] A disinfection composition was prepared in the same manner as in Example 1, except that ethanol was set to 50 parts by weight.

[Example 3] A disinfection composition was prepared in the same manner as in Example 1, except that the sodium chondroitin sulfate was set to 0.01 part by weight.

[Comparative Example 1] A disinfection composition was prepared in the same manner as in Example 1, except that 10 parts by weight of ethanol was used.

[Comparative Example 2] A disinfection composition was prepared in the same manner as in Example 1, except that ethanol was set to 70 parts by weight.

[Comparative Example 3] A disinfection composition was prepared in the same manner as in Example 1, except that the sodium chondroitin sulfate was not blended.

[Appearance properties] When evaluating the properties of the disinfecting composition just produced by visual inspection, as the evaluation criteria, the state where the sodium chondroitin sulfate was uniformly dissolved was evaluated as "○", and the sodium chondroitin sulfate was not dissolved or produced due to sulfuric acid. The state of dullness caused by sodium chondroitin was evaluated as "X", "○" was evaluated as good, and "X" was evaluated as poor.

[Moisturizing property] When evaluating the moisturizing property of the prepared disinfectant composition, as an evaluation criterion, five specialized sensory inspectors performed a five-stage sensory evaluation of the moisturizing feeling after use from 1:00 to 5:00, and obtained The average points are classified according to the following evaluation criteria, and “0” evaluation is better, and “△” evaluation and “×” evaluation are poor evaluations. ○: Average point is more than 4.0 △: Average point is more than 2.0 and less than 4.0 ×: Average point is less than 2.0

[Bactericidal efficacy] When evaluating the bactericidal efficacy of the prepared disinfection composition, directly contact the specimen and the bacterial solution and then apply it to the plate medium to evaluate the bacterial count. As the evaluation criteria, the ratio of the number of bacteria killed by contact with the disinfecting composition was 99.99% or more with respect to the number of bacteria in the control. ×”, “○” was evaluated as good, and “×” was evaluated as poor.

For Examples 1 to 3 and Comparative Examples 1 to 3, Table 1 shows the results regarding appearance properties, moisturizing properties, and bactericidal efficacy.

As shown in Table 1, when the composition of ethanol and water was blended with sodium chondroitin sulfate, although the moisture retention was good, when the blending amount of ethanol was 70 parts by weight, the sodium chondroitin sulfate could not be dissolved, and the blending of ethanol When the combined amount is about 10 parts by weight, the sterilization effect is not good. From these results, it was found that, as a composition for disinfection, in order to exhibit not only a good property of dissolving sodium chondroitin sulfate uniformly, but also a better bactericidal effect, the mixing ratio of ethanol, water and sodium chondroitin sulfate should be the specified range.

[Example 4] 30 parts by weight of ethanol, sodium chondroitin sulfate as a moisturizing agent (1.0 parts by weight, carboxyvinyl polymer as a tackifier (manufactured by Wako Pure Chemical Industries, Ltd., trade name: "HIVISWAKO103") 0.4 2 parts by weight, polyoxyethylene cetyl ether of nonionic surfactant (manufactured by Nikko Chemical Co., Ltd., trade name: "NIKKOL BC-15", HLB: 15.5), 2 weight parts of nonionic surfactant Glycerin stearate (manufactured by Nikko Chemical Co., Ltd., trade name: "NIKKOL MGS-AMV", HLB: 4.0) 2 parts by weight, fluidized paraffin wax (manufactured by Chuo Chemical Co., Ltd., trade name: "Fluid Paraffin 350S") ”) 1 part by weight, 1 part by weight of isopropyl myristate, 1 part by weight of isopropyl myristate, 0.5 part by weight of stearyl alcohol, 0.5 part by weight of glycerin as a moisturizing agent, dimethylpolysiloxane (Toray and Dow Corning) Co., Ltd., trade name: "Q7-9120SILICONE FLUID350CST") 0.2 parts by weight, 0.05 parts by weight of benzethonium chloride, 0.072 parts by weight of sodium hydroxide, and 100 parts by weight of residual water, mixed thoroughly A composition for disinfection is produced.

[Example 5] A composition for disinfection was prepared in the same manner as in Example 4, except that the amount of ethanol in Example 4 was set at 50 parts by weight. In addition, when the viscosity was measured in the same manner as in Example 4, it was 80 Pa·s.

[Example 6] A disinfection composition was prepared in the same manner as in Example 4, except that the sodium chondroitin sulfate was set to 0.5 part by weight in Example 4. In addition, when the viscosity was measured in the same manner as in Example 4, it was 95 Pa·s.

[Example 7] A disinfection composition was prepared in the same manner as in Example 4, except that the sodium chondroitin sulfate was set to 0.1 part by weight in Example 4. In addition, when the viscosity was measured in the same manner as in Example 4, it was 101 Pa·s.

[Example 8] A disinfection composition was prepared in the same manner as in Example 4, except that the sodium chondroitin sulfate in Example 4 was set at 0.01 part by weight. In addition, when the viscosity was measured in the same manner as in Example 4, it was 95 Pa·s.

[Comparative Example 4] A disinfection composition was prepared in the same manner as in Example 4, except that instead of the sodium chondroitin sulfate in Example 4, the sodium hyaluronate was changed to 0.01 part by weight. In addition, when the viscosity was measured in the same manner as in Example 4, it was 128 Pa·s.

[Comparative Example 5] The same procedure as in Example 4 was carried out except that the sodium chondroitin sulfate was not blended in Example 4, the carboxyvinyl polymer was set to 0.05 parts by weight, and the sodium hydroxide was set to 0.09 parts by weight. A composition for disinfection is produced. In addition, when the viscosity was measured in the same manner as in Example 4, it was 211 Pa·s.

[Comparative Example 6] Except that the ethanol in Example 4 was set to 40 parts by weight, the sodium chondroitin sulfate was not blended, and the carboxyvinyl polymer was set to 0.05 parts by weight and 0.09 parts by weight, the other parts were the same as the implementation Example 4 was carried out in the same manner to prepare a composition for disinfection. In addition, when the viscosity was measured in the same manner as in Example 4, it was 183 Pa·s.

[Comparative Example 7] A disinfection composition was prepared in the same manner as in Example 4, except that the ethanol in Example 4 was set to 70 parts by weight. In addition, there was separation or cloudiness after production, and the viscosity could not be measured in the same manner as in Example 4.

[Comparative Example 8] A disinfection composition was prepared in the same manner as in Example 4, except that the sodium chondroitin sulfate was set to 0.005 part by weight in Example 4. In addition, when the viscosity was measured in the same manner as in Example 4, it was 105 Pa·s.

[Comparative Example 9] A composition for disinfection was prepared in the same manner as in Example 4, except that ethanol was set to 10 parts by weight in Example 4. In addition, when the viscosity was measured in the same manner as in Example 4, it was 185 Pa·s.

[Appearance properties] When evaluating the properties of the prepared disinfectant composition by visual inspection, as an evaluation standard, the state in which the chondroitin sulfate sodium was uniformly dissolved and the separation in a creamy state was not observed was evaluated as "○". The state of blurring but dissolving chondroitin sulfate sodium and no separation was observed was evaluated as "△", the state that was separated but not uniform was evaluated as "X", "○" and "△" were evaluated as better. "X" was evaluated as poor.

[Moisturizing property] When evaluating the moisturizing property of the prepared disinfectant composition, five specialized sensory inspectors performed a five-stage sensory evaluation of the moisturizing feeling after use from 1:00 to 5:00, and obtained the average point. According to the following evaluation criteria, “0” evaluation is better, and “△” evaluation and “×” evaluation are poor evaluations. ○: Average point is more than 4.0 △: Average point is more than 2.0 and less than 4.0 ×: Average point is less than 2.0

[Bactericidal efficacy] When evaluating the bactericidal efficacy of the prepared disinfection composition, directly contact the specimen and the bacterial solution, and then smear it on the plate medium for cultivation, and evaluate the bacterial count. As the evaluation criteria, the ratio of the number of bacteria killed by contact with the disinfecting composition was 99.99% or more with respect to the number of bacteria in the control. ×”, “○” was evaluated as good, and “×” was evaluated as poor.

For Examples 4 to 8 and Comparative Examples 4 to 9, Table 2 shows the results regarding viscosity, appearance, moisture retention, and bactericidal efficacy.

From Table 2, it is understood that in the blending system of ethanol, sodium chondroitin sulfate, thickener, surfactant, water, etc., by making ethanol, sodium chondroitin sulfate, and water into the specified content ratio, the composition is used for disinfection. It is stable during production, can maintain cream-like properties, and has good moisturizing and bactericidal effects. In this way, by containing the oil and fat component, the tackifier and the surfactant, and the viscosity is within the specified range, even if the lower alcohol having 1 to 3 carbon atoms is blended in a high proportion, it is possible to form an excellent emulsion stability, and further use It can also prevent rough hands, a semi-solid form with good moisturizing properties, and a high-viscosity emulsification composition for disinfection.

[Comparative Example 10] A composition for disinfection with 78 parts by weight of ethanol, 0.4 parts by weight of carboxyvinyl polymer, 0.072 parts by weight of sodium hydroxide and water remaining was prepared.

[Comparative Example 11] A composition for disinfection with 54 parts by weight of ethanol, 0.4 parts by weight of carboxyvinyl polymer, 0.072 parts by weight of sodium hydroxide and water remaining was prepared.

The composition for disinfection of Example 8 and Comparative Examples 10 to 11 was measured for the amount of water evapotranspiration. That is, under the environment of temperature of about 25°C and humidity of 30-40%, the transepidermal water evapotranspiration amount of one coating time and 10 consecutive coating times of these disinfecting compositions was measured after one coating time. After 5 minutes and 10 minutes, it was measured using Tewameter TM300 (manufactured by Courage+Khazaka Corporation) after 5, 10, 20, and 30 minutes of continuous application. Then, from the difference between the transepidermal water evapotranspiration amount after the elapse of time and the transepidermal water evapotranspiration amount before application, the amount of change was calculated, and the skin barrier property of the skin was evaluated. From one application and 10 consecutive applications, the amount of change minus the difference in the amount of transdermal water transpiration before application was calculated from the amount of transdermal water transpiration after 10 minutes, and the amount of change was negative. were assessed as good. These results are shown in Table 3.

From Table 3, it is understood that in the disinfectant composition of Example 8, after 1 coating and after 10 coatings, the transdermal water evapotranspiration after 10 minutes is smaller than the transdermal water evapotranspiration before coating. After 10 minutes, the amount of change in the transepidermal water transpiration amount and the initial transdermal water transpiration amount became a negative number, the transpiration of water was suppressed, and the skin barrier properties were excellent compared with Comparative Examples 10 to 11. In addition, due to its excellent skin barrier properties, it is possible to prevent the invasion and infection of bacteria or viruses from the skin.

Claims (5)

A composition for disinfection, characterized by containing 20-60% by weight of a lower alcohol having 1 to 3 carbon atoms, 40-65% by weight of water, and 0.006-1% by weight of chondroitin sulfate or chondroitin sulfate. The disinfectant composition of claim 1 contains oil components, tackifiers and surfactants, and has a viscosity of 50-300 Pa･s at 25°C. The disinfectant composition according to claim 1 or claim 2, wherein the aforementioned tackifier is at least one selected from carboxyvinyl polymers and cellulose derivatives. The disinfectant composition according to claim 1 or claim 2, wherein the surfactant is a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol. The composition for disinfection according to claim 1 or claim 2, which contains a compound selected from the group consisting of benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, povidone iodine, and isopropylmethyl At least one disinfectant ingredient among phenol and chloroxylenol.